| Armistice Capital, LLC |
Delaware |
0 |
270000 |
0 |
0 |
270000 |
7.12 % |
14/11/2024 |
| Steven Boyd |
Delaware |
0 |
270000 |
0 |
0 |
270000 |
7.12 % |
14/11/2024 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
608272 |
0 |
0 |
608272 |
7.59 % |
01/02/2024 |
| James E. Flynn |
Delaware |
0 |
608272 |
0 |
0 |
608272 |
7.59 % |
01/02/2024 |
| Deerfield PDI Financing II, L.P. |
Delaware |
0 |
324817 |
0 |
0 |
324817 |
4.05 % |
01/02/2024 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
283455 |
0 |
0 |
283455 |
3.54 % |
01/02/2024 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
608272 |
0 |
0 |
608272 |
7.59 % |
01/02/2024 |
| Krishna Duvvuri |
U.S.A. |
326900 |
0 |
326900 |
0 |
326900 |
6.35 % |
13/11/2023 |
| Lind Global Partners II LLC |
Delaware |
475102 |
0 |
475102 |
0 |
475102 |
9.9 % |
28/04/2023 |
| Jeff Easton |
Delaware |
475102 |
0 |
475102 |
0 |
475102 |
9.9 % |
28/04/2023 |
| Lind Global Fund II LP |
Delaware |
475102 |
0 |
475102 |
0 |
475102 |
9.9 % |
28/04/2023 |
| Jonathan I. Cope |
Illinois |
0 |
459042 |
0 |
459042 |
459042 |
9.99 % |
24/04/2023 |
| Rockledge Capital Corporation |
Illinois |
0 |
459042 |
0 |
459042 |
459042 |
9.99 % |
24/04/2023 |
| Lincoln Park Capital, LLC |
Illinois |
0 |
459042 |
0 |
459042 |
459042 |
9.99 % |
24/04/2023 |
| Alex Noah Investors, Inc. |
Illinois |
0 |
459042 |
0 |
459042 |
459042 |
9.99 % |
24/04/2023 |
| Joshua B. Scheinfeld |
Illinois |
0 |
459042 |
0 |
459042 |
459042 |
9.99 % |
24/04/2023 |
| Lincoln Park Capital Fund, LLC |
Illinois |
0 |
459042 |
0 |
459042 |
459042 |
9.99 % |
24/04/2023 |
| Center
Laboratories, Inc. |
Taiwan |
1239088 |
304176 |
1239088 |
304176 |
1543264 |
5.4 % |
10/01/2022 |
| Bioengine
Capital Inc. |
Taiwan |
0 |
304176 |
0 |
304176 |
304176 |
1.1 % |
10/01/2022 |
| BARCLAYS GLOBAL INVESTORS, NA. |
Cayman Islands |
0 |
5227257 |
0 |
5227257 |
3616473 |
5.81 % |
19/11/2015 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
6496251 |
0 |
0 |
6496251 |
6.12 % |
27/07/2015 |
| Great Point Partners, LLC |
USA |
0 |
6496251 |
0 |
0 |
6496251 |
6.12 % |
27/07/2015 |
| Mr. David Kroin |
USA |
0 |
6496251 |
0 |
0 |
6496251 |
6.12 % |
27/07/2015 |
| Kevin Kotler |
Delaware |
0 |
3166000 |
0 |
3166000 |
3166000 |
5.77 % |
17/10/2013 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
3166000 |
0 |
3166000 |
3166000 |
5.77 % |
17/10/2013 |
| Broadfin Capital, LLC |
Delaware |
0 |
3166000 |
0 |
3166000 |
3166000 |
5.77 % |
17/10/2013 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
926874 |
0 |
0 |
926874 |
2.09 % |
22/02/2013 |
| Deerfield Private Design International II, L.P. |
Delaware |
0 |
1062126 |
0 |
0 |
1062126 |
2.38 % |
22/02/2013 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
307200 |
0 |
0 |
307200 |
0.7 % |
22/02/2013 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
2605080 |
0 |
0 |
2605080 |
5.65 % |
22/02/2013 |
| James E. Flynn |
Delaware |
0 |
2605080 |
0 |
0 |
2605080 |
5.65 % |
22/02/2013 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
2605080 |
0 |
0 |
2605080 |
5.65 % |
22/02/2013 |
| Deerfield Special Situations International Master Fund, L.P. |
Delaware |
0 |
308880 |
0 |
0 |
308880 |
0.7 % |
22/02/2013 |
| Wells Capital Management Incorporated |
California |
0 |
2283131 |
0 |
0 |
3312474 |
7.61 % |
13/02/2013 |
| Wells Fargo & Company |
Delaware |
0 |
3502949 |
0 |
0 |
3321590 |
8.05 % |
13/02/2013 |
| (1) BlackRock, Inc. |
Delaware |
3176349 |
0 |
3176349 |
0 |
3176349 |
7.3 % |
30/01/2013 |
| FMR LLC |
Delaware |
0 |
0 |
5647322 |
0 |
5647322 |
13 % |
10/10/2012 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
5647322 |
0 |
5647322 |
13 % |
10/10/2012 |
| U. S. Bancorp |
USA |
0 |
22000001 |
0 |
22000001 |
533300 |
5.37 % |
10/03/2011 |
| PharmaBio Development Inc. |
North Carolina |
0 |
0 |
0 |
0 |
11217591 |
5.6 % |
22/10/2010 |
| HEARTLAND ADVISORS, INC. |
WISCONSIN USA |
0 |
5182082 |
0 |
5283882 |
5283882 |
4.2 % |
08/01/2010 |
| WILLIAM J. NASGOVITZ |
WISCONSIN USA |
0 |
5182082 |
0 |
5283882 |
5283882 |
4.2 % |
08/01/2010 |
| 22-2007137 |
NEW JERSEY |
0 |
604032 |
0 |
604032 |
604032 |
4.9 % |
10/03/2000 |
| 22-1024240 |
NEW JERSEY |
0 |
604032 |
0 |
604032 |
604032 |
4.9 % |
10/03/2000 |
| 22-2007137 |
NEW JERSEY |
0 |
1289373 |
0 |
1289373 |
1289373 |
17.3 % |
19/04/1999 |
| 22-1024240 |
NEW JERSEY |
0 |
1289373 |
0 |
1289373 |
1289373 |
17.3 % |
19/04/1999 |
| Robert J. Capetola, Ph.D. |
United States |
619973 |
0 |
619973 |
0 |
619973 |
13.81 % |
08/09/1998 |
| 94-3171940 |
Delaware |
1212654 |
0 |
1212654 |
0 |
1212654 |
42.8 % |
04/02/1997 |