| Averill Master Fund, Ltd. |
Delaware |
0 |
3273770 |
0 |
3273770 |
3273770 |
8.3 % |
13/05/2024 |
| Suvretta Capital Management, LLC |
Delaware |
0 |
3685503 |
0 |
3685503 |
3685503 |
9.3 % |
13/05/2024 |
| Aaron Cowen |
Delaware |
0 |
3685503 |
0 |
3685503 |
3685503 |
9.3 % |
13/05/2024 |
| EIN #00-0000000 |
Jersey, Channel Islands |
0 |
2380667 |
0 |
2380667 |
2380667 |
6.1 % |
09/05/2024 |
| 00-0000000 |
Jersey, Channel Islands |
0 |
2380667 |
0 |
2380667 |
2380667 |
6.1 % |
09/05/2024 |
| Millennium Management LLC |
United States |
0 |
1362099 |
0 |
1362099 |
1362099 |
5.5 % |
04/12/2023 |
| Israel A. Englander |
United States |
0 |
1362099 |
0 |
1362099 |
1362099 |
5.5 % |
04/12/2023 |
| Millennium Group Management LLC |
United States |
0 |
1362099 |
0 |
1362099 |
1362099 |
5.5 % |
04/12/2023 |
| Integrated Core Strategies (US) LLC |
United States |
0 |
1334725 |
0 |
1334725 |
1334725 |
5.4 % |
04/12/2023 |
| Nantahala Capital Management, LLC |
MA |
0 |
1359687 |
0 |
0 |
1359687 |
7.9 % |
14/02/2023 |
| Daniel Mack |
MA |
0 |
1359687 |
0 |
0 |
1359687 |
7.9 % |
14/02/2023 |
| Wilmot B. Harkey |
MA |
0 |
1359687 |
0 |
0 |
1359687 |
7.9 % |
14/02/2023 |
| Steven Boyd |
United States of America |
0 |
1106000 |
0 |
0 |
1106000 |
6.44 % |
14/02/2023 |
| Armistice Capital, LLC |
Delaware |
0 |
1106000 |
0 |
0 |
1106000 |
6.44 % |
14/02/2023 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
1739130 |
0 |
0 |
1739130 |
5.06 % |
16/11/2022 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
1739130 |
0 |
0 |
1739130 |
5.06 % |
16/11/2022 |
| James E. Flynn |
Delaware |
0 |
1739130 |
0 |
0 |
1739130 |
5.06 % |
16/11/2022 |
| Deerfield Partners, L.P. |
Delaware |
0 |
1739130 |
0 |
0 |
1739130 |
5.06 % |
16/11/2022 |
| Oleg Nodelman |
United States |
0 |
1785663 |
0 |
1785663 |
1785663 |
11 % |
14/11/2022 |
| EcoR1 Capital, LLC |
United States |
0 |
1785663 |
0 |
1785663 |
1785663 |
11 % |
14/11/2022 |
| EcoR1 Capital Fund Qualified, L.P. |
United States |
0 |
1722620 |
0 |
1722620 |
1722620 |
11 % |
14/11/2022 |
| Point72 Capital Advisors, Inc. |
United States |
0 |
888870 |
0 |
960870 |
888870 |
4 % |
09/11/2022 |
| Point72 Asset Management, L.P. |
United States |
0 |
888870 |
0 |
960870 |
888870 |
4 % |
09/11/2022 |
| Steven A. Cohen |
United States |
0 |
888870 |
0 |
960870 |
888870 |
4 % |
09/11/2022 |
| 27-4413262 |
United States |
791818 |
0 |
791818 |
0 |
791818 |
6.1 % |
04/11/2022 |
| Identification Nos. of above persons (. |
United States |
791818 |
0 |
791818 |
0 |
791818 |
6.1 % |
04/11/2022 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
8007272 |
0 |
0 |
8007272 |
5.46 % |
10/02/2022 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
8007272 |
0 |
0 |
8007272 |
5.46 % |
10/02/2022 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
8007272 |
0 |
0 |
8007272 |
5.46 % |
10/02/2022 |
| Robert Atchinson |
Delaware |
0 |
8007272 |
0 |
0 |
8007272 |
5.46 % |
10/02/2022 |
| Phillip Gross |
Delaware |
0 |
8007272 |
0 |
0 |
8007272 |
5.46 % |
10/02/2022 |
| Great Point Partners, LLC |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| CVI Investments, Inc. |
|
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Heights Capital Management, Inc. |
|
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
967717 |
0 |
967717 |
967717 |
0.98 % |
03/02/2021 |
| Capital LLC |
York |
0 |
1364196 |
0 |
1364196 |
1364196 |
1.6 % |
21/08/2020 |
| Rouhandeh |
States |
1175843 |
13364660 |
1055843 |
13364660 |
14540503 |
15.8 % |
21/08/2020 |
| Capital Partners LLC |
Delaware |
0 |
11999292 |
0 |
11999292 |
11999292 |
14.1 % |
21/08/2020 |
| Great Point Partners, LLC |
Delaware |
0 |
8488882 |
0 |
0 |
8488882 |
9.99 % |
07/07/2020 |
| Mr. David Kroin |
Delaware |
0 |
8488882 |
0 |
0 |
8488882 |
9.99 % |
07/07/2020 |
| Dr. Jeffrey R. Jay, M.D. |
Delaware |
0 |
8488882 |
0 |
0 |
8488882 |
9.99 % |
07/07/2020 |
| 52-0556948 |
Maryland |
2109 |
0 |
2109 |
0 |
2109 |
0 % |
14/02/2020 |
| Phillip Gross |
United States |
0 |
5000000 |
0 |
0 |
5000000 |
5.99 % |
12/02/2020 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
5000000 |
0 |
0 |
5000000 |
5.99 % |
12/02/2020 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
5000000 |
0 |
0 |
5000000 |
5.99 % |
12/02/2020 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
5000000 |
0 |
0 |
5000000 |
5.99 % |
12/02/2020 |
| Robert Atchinson |
United States |
0 |
5000000 |
0 |
0 |
5000000 |
5.99 % |
12/02/2020 |
| Heights Capital Management, Inc. |
Delaware |
0 |
5227371 |
0 |
5227371 |
5227371 |
6.3 % |
10/02/2020 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
5227371 |
0 |
5227371 |
5227371 |
6.3 % |
10/02/2020 |
| Millennium International Management LP |
|
0 |
537503 |
0 |
537503 |
537503 |
0.6 % |
06/02/2020 |
| ICS Opportunities, Ltd. |
|
0 |
457641 |
0 |
457641 |
457641 |
0.5 % |
06/02/2020 |
| ICS Opportunities II LLC |
|
0 |
75000 |
0 |
75000 |
75000 |
0.1 % |
06/02/2020 |
| Israel A. Englander |
|
0 |
3404642 |
0 |
3404642 |
3404642 |
4.1 % |
06/02/2020 |
| Integrated Assets II LLC |
|
0 |
0 |
0 |
0 |
0 |
0 % |
06/02/2020 |
| Integrated Core Strategies (US) LLC |
|
0 |
2867139 |
0 |
2867139 |
2867139 |
3.4 % |
06/02/2020 |
| Millennium Group Management LLC |
|
0 |
3404642 |
0 |
3404642 |
3404642 |
4.1 % |
06/02/2020 |
| Millennium Management LLC |
|
0 |
3404642 |
0 |
3404642 |
3404642 |
4.1 % |
06/02/2020 |
| Integrated Assets, Ltd. |
|
0 |
4862 |
0 |
4862 |
4862 |
0 % |
06/02/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
6333596 |
0 |
0 |
6709161 |
8.04 % |
28/01/2020 |
| Wellington Management Company LLP |
Delaware |
0 |
6333596 |
0 |
0 |
6482583 |
7.77 % |
28/01/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
6333596 |
0 |
0 |
6709161 |
8.04 % |
28/01/2020 |
| Wellington Management Group LLP |
Delaware |
0 |
6333596 |
0 |
0 |
6709161 |
8.04 % |
28/01/2020 |
| Dr.
Jeffrey R. Jay, M.D. |
or Place of Organization United States |
0 |
8459960 |
0 |
10 |
8459960 |
9.99 % |
30/12/2019 |
| Great
Point Partners, LLC |
or Place of Organization Delaware |
0 |
8459960 |
0 |
10 |
8459960 |
9.99 % |
30/12/2019 |
| Mr. David Kroin |
or Place of Organization United States |
0 |
8459960 |
0 |
10 |
8459960 |
9.99 % |
30/12/2019 |
| Heights Capital Management, Inc. |
Delaware |
0 |
6000000 |
0 |
6000000 |
6000000 |
7.7 % |
27/12/2019 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
6000000 |
0 |
6000000 |
6000000 |
7.7 % |
27/12/2019 |
| Great Point Partners, LLC |
USA |
0 |
2833656 |
0 |
2833656 |
2833656 |
5.7 % |
16/09/2019 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2833656 |
0 |
2833656 |
2833656 |
5.7 % |
16/09/2019 |
| Mr. David Kroin |
USA |
0 |
2833656 |
0 |
2833656 |
2833656 |
5.7 % |
16/09/2019 |
| 52-0556948 |
Maryland |
433113 |
0 |
2549555 |
0 |
2549555 |
5.3 % |
14/02/2019 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
2600000 |
0 |
0 |
2600000 |
5.42 % |
13/02/2019 |
| Robert Atchinson |
United States |
0 |
2600000 |
0 |
0 |
2600000 |
5.42 % |
13/02/2019 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
2600000 |
0 |
0 |
2600000 |
5.42 % |
13/02/2019 |
| Phillip Gross |
United States |
0 |
2600000 |
0 |
0 |
2600000 |
5.42 % |
13/02/2019 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
2600000 |
0 |
0 |
2600000 |
5.42 % |
13/02/2019 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3815820 |
0 |
0 |
4071217 |
8.49 % |
12/02/2019 |
| Wellington Group Holdings LLP |
Delaware |
0 |
3815820 |
0 |
0 |
4071217 |
8.49 % |
12/02/2019 |
| Wellington Management Group LLP |
Delaware |
0 |
3815820 |
0 |
0 |
4071217 |
8.49 % |
12/02/2019 |
| Wellington Management Company LLP |
Delaware |
0 |
3815820 |
0 |
0 |
3924654 |
8.19 % |
12/02/2019 |
| Viking Global Investors LP |
Cayman Islands |
0 |
213072 |
0 |
213072 |
293518 |
0.6 % |
10/01/2019 |
| FMR LLC |
Delaware |
70000 |
0 |
4779191 |
0 |
4779191 |
10.217 % |
12/03/2018 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
2413959 |
0 |
0 |
2413959 |
5.16 % |
14/02/2018 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
2413959 |
0 |
0 |
2413959 |
5.16 % |
14/02/2018 |
| Phillip Gross |
United States |
0 |
2413959 |
0 |
0 |
2413959 |
5.16 % |
14/02/2018 |
| Robert Atchinson |
United States |
0 |
2413959 |
0 |
0 |
2413959 |
5.16 % |
14/02/2018 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
2413959 |
0 |
0 |
2413959 |
5.16 % |
14/02/2018 |
| O. Andreas Halvorsen |
Delaware |
0 |
2238720 |
0 |
2238720 |
2238720 |
5.6 % |
02/10/2017 |
| Viking Long Fund Master Ltd. |
Delaware |
0 |
648720 |
0 |
648720 |
648720 |
1.6 % |
02/10/2017 |
| Rose S. Shabet |
Delaware |
0 |
2238720 |
0 |
2238720 |
2238720 |
5.6 % |
02/10/2017 |
| Viking Global Equities LP |
Delaware |
0 |
542190 |
0 |
542190 |
542190 |
1.3 % |
02/10/2017 |
| VGE III Portfolio Ltd. |
Delaware |
0 |
1016010 |
0 |
1016010 |
1016010 |
2.5 % |
02/10/2017 |
| Viking Long Fund GP LLC |
Delaware |
0 |
648720 |
0 |
648720 |
648720 |
1.6 % |
02/10/2017 |
| Viking Global Equities II LP |
Delaware |
0 |
31800 |
0 |
31800 |
31800 |
0.1 % |
02/10/2017 |
| Viking Global Investors LP |
Delaware |
0 |
2238720 |
0 |
2238720 |
2238720 |
5.6 % |
02/10/2017 |
| Viking Global Performance LLC |
Delaware |
0 |
1590000 |
0 |
1590000 |
1590000 |
3.9 % |
02/10/2017 |
| David C. Ott |
Delaware |
0 |
2238720 |
0 |
2238720 |
2238720 |
5.6 % |
02/10/2017 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
2175000 |
0 |
0 |
2175000 |
5.4 % |
15/09/2017 |
| Phillip Gross |
Delaware |
0 |
2175000 |
0 |
0 |
2175000 |
5.4 % |
15/09/2017 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
2175000 |
0 |
0 |
2175000 |
5.4 % |
15/09/2017 |
| Robert Atchinson |
Delaware |
0 |
2175000 |
0 |
0 |
2175000 |
5.4 % |
15/09/2017 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
2175000 |
0 |
0 |
2175000 |
5.4 % |
15/09/2017 |
| Knoll Capital Management, LP |
Delaware |
0 |
2359767 |
0 |
2359767 |
2359767 |
6.1 % |
04/11/2016 |
| 2. |
Delaware, United States of America |
0 |
1762881 |
0 |
1762881 |
1762881 |
5.39 % |
16/02/2016 |
| 2. |
Delaware, United States of America |
0 |
1762881 |
0 |
1762881 |
1762881 |
5.39 % |
16/02/2016 |
| Oracle Associates, LLC |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2016 |
| Oracle Institutional Partners, L.P. |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2016 |
| Oracle Partners, L.P. |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2016 |
| Larry N. Feinberg |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2016 |
| Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
550000 |
0 |
550000 |
700000 |
2.97 % |
28/05/2015 |
| Advisors LLC |
Delaware, United States of America |
0 |
1250000 |
0 |
0 |
1250000 |
6.04 % |
17/02/2015 |
| Joseph Edelman |
Delaware, United States of America |
0 |
1250000 |
0 |
21 |
1250000 |
6.04 % |
17/02/2015 |
| Oracle Institutional Partners, L.P. |
Delaware |
0 |
907822 |
0 |
0 |
907822 |
4.4 % |
13/02/2015 |
| Oracle Partners, L.P. |
Delaware |
0 |
1779073 |
0 |
0 |
1779073 |
8.6 % |
13/02/2015 |
| Larry N. Feinberg |
United States |
0 |
2686895 |
0 |
0 |
2686895 |
13 % |
13/02/2015 |
| Oracle Associates, LLC |
Delaware |
0 |
2686895 |
0 |
0 |
2686895 |
13 % |
13/02/2015 |
| Ayer Capital Management, LP |
Delaware USA |
0 |
1925433 |
0 |
1925433 |
1925433 |
7.97 % |
25/10/2012 |
| ACM Capital Partners, LLC |
USA |
0 |
2758620 |
0 |
2758620 |
2758620 |
12 % |
14/11/2011 |
| Ayer Capital Partners Master Fund, L.P. |
USA |
0 |
2528440 |
0 |
2528440 |
2528440 |
11 % |
14/11/2011 |
| Ayer Capital Partners, LLC |
USA |
0 |
2528440 |
0 |
2528440 |
2528440 |
11 % |
14/11/2011 |
| Ayer Capital Management, LP |
USA |
0 |
2758620 |
0 |
2758620 |
2758620 |
12 % |
14/11/2011 |
| Jay Venkatesan |
USA |
0 |
2758620 |
0 |
2758620 |
2758620 |
12 % |
14/11/2011 |
| #39-1078128 |
WISCONSIN, U.S.A. |
0 |
158380 |
0 |
158380 |
158380 |
4.5 % |
08/08/2006 |
| WILLIAM J. NASGOVITZ |
U.S.A. |
0 |
158380 |
0 |
158380 |
158380 |
4.5 % |
08/08/2006 |
| #39-1078128 |
WISCONSIN, U.S.A. |
0 |
1506200 |
0 |
1586200 |
1586200 |
9 % |
03/02/2006 |
| WILLIAM J. NASGOVITZ |
U.S.A. |
0 |
1506200 |
0 |
1586200 |
1586200 |
9 % |
03/02/2006 |
| WILLIAM J. NASGOVITZ |
U.S.A. |
0 |
1592600 |
0 |
1715300 |
1715300 |
11.05 % |
13/01/2005 |
| #39-1078128 |
WISCONSIN, U.S.A. |
0 |
1592600 |
0 |
1715300 |
1715300 |
11.05 % |
13/01/2005 |
| Kerry P. Gray |
Australian |
0 |
16672 |
879583 |
16672 |
879583 |
7.5 % |
18/02/2004 |
| WILLIAM J. NASGOVITZ |
U.S.A. |
0 |
1588200 |
0 |
1806100 |
1806100 |
13.5 % |
12/02/2004 |
| #39-1078128 |
WISCONSIN, U.S.A. |
0 |
1588200 |
0 |
1806100 |
1806100 |
13.5 % |
12/02/2004 |
| Kerry P. Gray |
Australian |
837081 |
0 |
837081 |
0 |
1064462 |
7.6 % |
14/02/2003 |
| #39-1078128 |
WISCONSIN, U.S.A. |
355800 |
0 |
1849100 |
0 |
1849100 |
14.1 % |
12/02/2003 |
| ###-##-#### |
U.S.A. |
1253400 |
0 |
0 |
0 |
1253400 |
9.5 % |
12/02/2003 |
| Kerry P. Gray |
Australian |
585548 |
0 |
585548 |
0 |
760088 |
5.7 % |
02/11/2001 |