Roderick Wong, M.D. |
United States |
0 |
13707506 |
0 |
13707506 |
13707506 |
8.3 % |
14/11/2024 |
RTW Investments, LP |
Delaware |
0 |
13707506 |
0 |
13707506 |
13707506 |
8.3 % |
14/11/2024 |
RTW Investments, LP |
Delaware |
0 |
11253551 |
0 |
11253551 |
11253551 |
6.9 % |
14/02/2024 |
Roderick Wong, M.D. |
United States |
0 |
11253551 |
0 |
11253551 |
11253551 |
6.9 % |
14/02/2024 |
The Vanguard Group |
Pennsylvania |
0 |
220637 |
13055348 |
340661 |
13396009 |
8.16 % |
13/02/2024 |
Abigail P. Johnson |
United States of America |
0 |
0 |
5265357 |
0 |
5265357 |
3.207 % |
09/02/2024 |
FMR LLC |
Delaware |
5263805 |
0 |
5265357 |
0 |
5265357 |
3.207 % |
09/02/2024 |
BlackRock, Inc. |
Delaware |
11054182 |
0 |
11409218 |
0 |
11409218 |
6.9 % |
26/01/2024 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
902866 |
0 |
4279254 |
0 |
4279254 |
2.6 % |
14/02/2023 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
902866 |
0 |
4279254 |
0 |
4279254 |
2.6 % |
14/02/2023 |
The Vanguard Group |
Pennsylvania |
0 |
201949 |
12953166 |
326609 |
13279775 |
8.2 % |
09/02/2023 |
BlackRock, Inc. |
Delaware |
10043538 |
0 |
10258738 |
0 |
10258738 |
6.3 % |
31/01/2023 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
2857590 |
0 |
9486261 |
0 |
9486261 |
5.9 % |
14/02/2022 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
2857590 |
0 |
9486261 |
0 |
9486261 |
5.9 % |
14/02/2022 |
The Vanguard Group |
Pennsylvania |
0 |
226082 |
11986263 |
329103 |
12315366 |
7.66 % |
09/02/2022 |
BlackRock, Inc. |
Delaware |
9840066 |
0 |
10060312 |
0 |
10060312 |
6.3 % |
04/02/2022 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
1518225 |
0 |
7877825 |
0 |
7877825 |
4.9 % |
16/02/2021 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
1518225 |
0 |
7877825 |
0 |
7877825 |
4.9 % |
16/02/2021 |
The Vanguard Group |
Pennsylvania |
0 |
90167 |
10422274 |
183499 |
10605773 |
6.67 % |
10/02/2021 |
FMR LLC |
Delaware |
6879328 |
0 |
19472913 |
0 |
19472913 |
12.248 % |
08/02/2021 |
Abigail P. Johnson |
United States of America |
0 |
0 |
19472913 |
0 |
19472913 |
12.248 % |
08/02/2021 |
BlackRock, Inc. |
Delaware |
7298817 |
0 |
7757846 |
0 |
7757846 |
4.97 % |
10/07/2020 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
2299504 |
0 |
13241014 |
0 |
13241014 |
8.5 % |
14/02/2020 |
The Vanguard Group |
Pennsylvania |
235865 |
21074 |
10373113 |
243500 |
10616613 |
6.89 % |
12/02/2020 |
FMR LLC |
Delaware |
6716436 |
0 |
20890917 |
0 |
20890917 |
13.563 % |
07/02/2020 |
Fidelity Growth Company Fund |
Massachusetts |
7923598 |
0 |
0 |
0 |
7923598 |
5.144 % |
07/02/2020 |
FMR LLC |
Delaware |
6716436 |
0 |
20890917 |
0 |
20890917 |
13.563 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
20890917 |
0 |
20890917 |
13.563 % |
07/02/2020 |
Fidelity Growth Company Fund |
Massachusetts |
7923598 |
0 |
0 |
0 |
7923598 |
5.144 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
20890917 |
0 |
20890917 |
13.563 % |
07/02/2020 |
BlackRock, Inc. |
Delaware |
9955835 |
0 |
10238895 |
0 |
10238895 |
6.6 % |
05/02/2020 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
5378 |
0 |
5378 |
5378 |
0.1 % |
14/02/2019 |
Steven A. Cohen |
United States |
0 |
2251978 |
0 |
2251978 |
2251978 |
1.6 % |
14/02/2019 |
Point72 Asset Management, L.P. |
Delaware |
0 |
2246600 |
0 |
2246600 |
2246600 |
1.6 % |
14/02/2019 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
2246600 |
0 |
2246600 |
2246600 |
1.6 % |
14/02/2019 |
Point72 Hong Kong Limited |
Hong Kong |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2019 |
Abigail P. Johnson |
United States of America |
0 |
0 |
21543893 |
0 |
21543893 |
14.999 % |
13/02/2019 |
FMR LLC |
Delaware |
5559214 |
0 |
21543893 |
0 |
21543893 |
14.999 % |
13/02/2019 |
Fidelity Growth Company Fund |
Massachusetts |
7192768 |
0 |
0 |
0 |
7192768 |
5.007 % |
13/02/2019 |
Janus Henderson Group plc EIN |
Jersey, Channel Islands |
0 |
3142042 |
0 |
3142042 |
3142042 |
2.2 % |
11/02/2019 |
The Vanguard Group |
Pennsylvania |
206333 |
19974 |
9925433 |
216231 |
10141664 |
7.06 % |
11/02/2019 |
BlackRock, Inc. |
Delaware |
9889352 |
0 |
10133466 |
0 |
10133466 |
7.2 % |
04/02/2019 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
6344600 |
0 |
6344600 |
6344600 |
5.1 % |
18/06/2018 |
Point72 Asset Management, L.P. |
Delaware |
0 |
6344600 |
0 |
6344600 |
6344600 |
5.1 % |
18/06/2018 |
Point72 Asset Management, L.P. |
Delaware |
0 |
6344600 |
0 |
6344600 |
6344600 |
5.1 % |
18/06/2018 |
Steven A. Cohen |
United States |
0 |
6521566 |
0 |
6521566 |
6521566 |
5.2 % |
18/06/2018 |
Point72 Hong Kong Limited |
Hong Kong |
0 |
1459 |
0 |
1459 |
1459 |
0.1 % |
18/06/2018 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
175507 |
0 |
175507 |
175507 |
0.1 % |
18/06/2018 |
Steven A. Cohen |
United States |
0 |
6521566 |
0 |
6521566 |
6521566 |
5.2 % |
18/06/2018 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
6344600 |
0 |
6344600 |
6344600 |
5.1 % |
18/06/2018 |
Point72 Hong Kong Limited |
Hong Kong |
0 |
1459 |
0 |
1459 |
1459 |
0.1 % |
18/06/2018 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
175507 |
0 |
175507 |
175507 |
0.1 % |
18/06/2018 |
FMR LLC |
Delaware |
4245175 |
0 |
18630845 |
0 |
18630845 |
14.999 % |
13/02/2018 |
Abigail P. Johnson |
United States of America |
0 |
0 |
18630845 |
0 |
18630845 |
14.999 % |
13/02/2018 |
Fidelity Growth Company Fund |
Massachusetts |
7178108 |
0 |
0 |
0 |
7178108 |
5.779 % |
13/02/2018 |
Janus Henderson Group plc EIN |
Jersey, Channel Islands |
0 |
6781284 |
0 |
6781284 |
6781284 |
5.5 % |
12/02/2018 |
The Vanguard Group |
Pennsylvania |
54648 |
10974 |
7927576 |
57621 |
7985197 |
6.42 % |
08/02/2018 |
BlackRock, Inc. |
Delaware |
6374962 |
0 |
6710697 |
0 |
6710697 |
5.4 % |
01/02/2018 |
Abigail P. Johnson |
United States of America |
0 |
0 |
18167076 |
0 |
18167076 |
14.999 % |
14/02/2017 |
FMR LLC |
Delaware |
1844554 |
0 |
18167076 |
0 |
18167076 |
14.999 % |
14/02/2017 |
Fidelity Growth Company Fund |
Massachusetts |
6769899 |
0 |
0 |
0 |
6769899 |
5.589 % |
14/02/2017 |
The Vanguard Group |
Pennsylvania |
55209 |
10974 |
7060126 |
61518 |
7121644 |
5.88 % |
08/02/2017 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
946064 |
0 |
5658297 |
0 |
5658297 |
4.6 % |
06/02/2017 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
946064 |
0 |
5658297 |
0 |
5658297 |
4.6 % |
06/02/2017 |
BlackRock, Inc. |
Delaware |
4437793 |
0 |
4757952 |
0 |
4757952 |
4.2 % |
08/07/2016 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
RA Capital Management, LLC |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Peter Kolchinsky |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Peter Kolchinsky |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
RA Capital Management, LLC |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
FMR LLC |
Delaware |
872214 |
0 |
15136743 |
0 |
15136743 |
14.999 % |
12/02/2016 |
Fidelity Growth Company Fund |
Massachusetts |
5745055 |
0 |
0 |
0 |
5745055 |
5.693 % |
12/02/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
15136743 |
0 |
15136743 |
14.999 % |
12/02/2016 |
T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
5594715 |
5.5 % |
11/02/2016 |
The Vanguard Group |
Pennsylvania |
169309 |
5000 |
5432247 |
169409 |
5601656 |
5.55 % |
10/02/2016 |
BlackRock, Inc. |
Delaware |
5664551 |
0 |
5847357 |
0 |
5847357 |
5.8 % |
25/01/2016 |
RA Capital Management, LLC |
Massachusetts |
0 |
2496178 |
0 |
|
2496178 |
6.4 % |
03/04/2015 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
1248095 |
0 |
1248095 |
1248095 |
3.2 % |
03/04/2015 |
Peter Kolchinsky |
United States |
0 |
2496178 |
0 |
2496178 |
2496178 |
6.4 % |
03/04/2015 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
1248095 |
0 |
1248095 |
1248095 |
3.2 % |
03/04/2015 |
RA Capital Management, LLC |
Massachusetts |
0 |
2496178 |
0 |
|
2496178 |
6.4 % |
03/04/2015 |
Peter Kolchinsky |
United States |
0 |
2496178 |
0 |
2496178 |
2496178 |
6.4 % |
03/04/2015 |
Peter Kolchinsky |
United States |
0 |
1027300 |
0 |
1027300 |
1027300 |
1 % |
17/02/2015 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
767910 |
0 |
767910 |
767910 |
0.8 % |
17/02/2015 |
Peter Kolchinsky |
United States |
0 |
1027300 |
0 |
1027300 |
1027300 |
1 % |
17/02/2015 |
RA Capital Management, LLC |
Massachusetts |
0 |
1027300 |
0 |
|
1027300 |
1 % |
17/02/2015 |
RA Capital Management, LLC |
Massachusetts |
0 |
1027300 |
0 |
|
1027300 |
1 % |
17/02/2015 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
767910 |
0 |
767910 |
767910 |
0.8 % |
17/02/2015 |
Viking Long Fund Master Ltd. _____________________________________________________________________________ |
Cayman Islands |
|
859606 |
0 |
859606 |
859606 |
0.9 % |
17/02/2015 |
David C. Ott _____________________________________________________________________________ |
United States |
|
2956266 |
0 |
2956266 |
2956266 |
3 % |
17/02/2015 |
Thomas W. Purcell, Jr. _____________________________________________________________________________ |
United States |
|
2956266 |
0 |
2956266 |
2956266 |
3 % |
17/02/2015 |
Daniel S. Sundheim _____________________________________________________________________________ |
United States |
|
2956266 |
0 |
2956266 |
2956266 |
3 % |
17/02/2015 |
VGE III Portfolio Ltd. _____________________________________________________________________________ |
Cayman Islands |
|
1339761 |
0 |
1339761 |
1339761 |
1.3 % |
17/02/2015 |
Viking Global Equities II LP _____________________________________________________________________________ |
Delaware |
|
41936 |
0 |
41936 |
41936 |
0 % |
17/02/2015 |
Viking Global Equities LP _____________________________________________________________________________ |
Delaware |
|
714963 |
0 |
714963 |
714963 |
0.7 % |
17/02/2015 |
Viking Global Performance LLC _____________________________________________________________________________ |
Delaware |
|
2096660 |
0 |
2096660 |
2096660 |
2.1 % |
17/02/2015 |
Viking Global Equities II LP _____________________________________________________________________________ |
Delaware |
|
41936 |
0 |
41936 |
41936 |
0 % |
17/02/2015 |
VGE III Portfolio Ltd. _____________________________________________________________________________ |
Cayman Islands |
|
1339761 |
0 |
1339761 |
1339761 |
1.3 % |
17/02/2015 |
Viking Long Fund GP LLC _____________________________________________________________________________ |
Delaware |
|
859606 |
0 |
859606 |
859606 |
0.9 % |
17/02/2015 |
Viking Long Fund Master Ltd. _____________________________________________________________________________ |
Cayman Islands |
|
859606 |
0 |
859606 |
859606 |
0.9 % |
17/02/2015 |
O. Andreas Halvorsen _____________________________________________________________________________ |
Norway |
|
2956266 |
0 |
2956266 |
2956266 |
3 % |
17/02/2015 |
David C. Ott _____________________________________________________________________________ |
United States |
|
2956266 |
0 |
2956266 |
2956266 |
3 % |
17/02/2015 |
Thomas W. Purcell, Jr. _____________________________________________________________________________ |
United States |
|
2956266 |
0 |
2956266 |
2956266 |
3 % |
17/02/2015 |
Daniel S. Sundheim _____________________________________________________________________________ |
United States |
|
2956266 |
0 |
2956266 |
2956266 |
3 % |
17/02/2015 |
Viking Global Investors LP _____________________________________________________________________________ |
Delaware |
|
2956266 |
0 |
2956266 |
2956266 |
3 % |
17/02/2015 |
Viking Long Fund GP LLC _____________________________________________________________________________ |
Delaware |
|
859606 |
0 |
859606 |
859606 |
0.9 % |
17/02/2015 |
O. Andreas Halvorsen _____________________________________________________________________________ |
Norway |
|
2956266 |
0 |
2956266 |
2956266 |
3 % |
17/02/2015 |
Viking Global Equities LP _____________________________________________________________________________ |
Delaware |
|
714963 |
0 |
714963 |
714963 |
0.7 % |
17/02/2015 |
Viking Global Performance LLC _____________________________________________________________________________ |
Delaware |
|
2096660 |
0 |
2096660 |
2096660 |
2.1 % |
17/02/2015 |
Viking Global Investors LP _____________________________________________________________________________ |
Delaware |
|
2956266 |
0 |
2956266 |
2956266 |
3 % |
17/02/2015 |
T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
6240798 |
6.2 % |
12/02/2015 |
BlackRock, Inc. |
Delaware |
5407580 |
0 |
5581281 |
0 |
5581281 |
5.6 % |
02/02/2015 |
Viking Global Equities II LP _____________________________________________________________________________ |
Delaware |
0 |
74963 |
0 |
74963 |
74963 |
0.1 % |
05/05/2014 |
VGE III Portfolio Ltd. _____________________________________________________________________________ |
Cayman Islands |
0 |
2395062 |
0 |
2395062 |
2395062 |
2.4 % |
05/05/2014 |
Viking Long Fund GP LLC _____________________________________________________________________________ |
Delaware |
0 |
1210717 |
0 |
1210717 |
1210717 |
1.2 % |
05/05/2014 |
Viking Long Fund Master Ltd. _____________________________________________________________________________ |
Cayman Islands |
0 |
1210717 |
0 |
1210717 |
1210717 |
1.2 % |
05/05/2014 |
O. Andreas Halvorsen _____________________________________________________________________________ |
Norway |
0 |
4958861 |
0 |
4958861 |
4958861 |
5 % |
05/05/2014 |
David C. Ott _____________________________________________________________________________ |
United States |
0 |
4958861 |
0 |
4958861 |
4958861 |
5 % |
05/05/2014 |
Thomas W. Purcell, Jr. _____________________________________________________________________________ |
United States |
0 |
4958861 |
0 |
4958861 |
4958861 |
5 % |
05/05/2014 |
Daniel S. Sundheim _____________________________________________________________________________ |
United States |
0 |
4958861 |
0 |
4958861 |
4958861 |
5 % |
05/05/2014 |
Viking Global Investors LP _____________________________________________________________________________ |
Delaware |
0 |
4958861 |
0 |
4958861 |
4958861 |
5 % |
05/05/2014 |
Viking Global Performance LLC _____________________________________________________________________________ |
Delaware |
0 |
3748144 |
0 |
3748144 |
3748144 |
3.8 % |
05/05/2014 |
Viking Global Equities LP _____________________________________________________________________________ |
Delaware |
0 |
1278119 |
0 |
1278119 |
1278119 |
1.3 % |
05/05/2014 |
Viking Global Equities II LP _____________________________________________________________________________ |
Delaware |
0 |
74963 |
0 |
74963 |
74963 |
0.1 % |
05/05/2014 |
VGE III Portfolio Ltd. _____________________________________________________________________________ |
Cayman Islands |
0 |
2395062 |
0 |
2395062 |
2395062 |
2.4 % |
05/05/2014 |
Viking Long Fund GP LLC _____________________________________________________________________________ |
Delaware |
0 |
1210717 |
0 |
1210717 |
1210717 |
1.2 % |
05/05/2014 |
Viking Long Fund Master Ltd. _____________________________________________________________________________ |
Cayman Islands |
0 |
1210717 |
0 |
1210717 |
1210717 |
1.2 % |
05/05/2014 |
O. Andreas Halvorsen _____________________________________________________________________________ |
Norway |
0 |
4958861 |
0 |
4958861 |
4958861 |
5 % |
05/05/2014 |
David C. Ott _____________________________________________________________________________ |
United States |
0 |
4958861 |
0 |
4958861 |
4958861 |
5 % |
05/05/2014 |
Thomas W. Purcell, Jr. _____________________________________________________________________________ |
United States |
0 |
4958861 |
0 |
4958861 |
4958861 |
5 % |
05/05/2014 |
Daniel S. Sundheim _____________________________________________________________________________ |
United States |
0 |
4958861 |
0 |
4958861 |
4958861 |
5 % |
05/05/2014 |
Viking Global Investors LP _____________________________________________________________________________ |
Delaware |
0 |
4958861 |
0 |
4958861 |
4958861 |
5 % |
05/05/2014 |
Viking Global Performance LLC _____________________________________________________________________________ |
Delaware |
0 |
3748144 |
0 |
3748144 |
3748144 |
3.8 % |
05/05/2014 |
Viking Global Equities LP _____________________________________________________________________________ |
Delaware |
0 |
1278119 |
0 |
1278119 |
1278119 |
1.3 % |
05/05/2014 |
JG Asset, LLC |
United States |
0 |
1115545 |
0 |
1115545 |
1115545 |
1.2 % |
14/02/2014 |
Visium Balanced Master Fund, Ltd. |
Cayman Islands |
0 |
997860 |
0 |
997860 |
997860 |
1.1 % |
14/02/2014 |
Jacob Gottlieb |
United States |
0 |
1115545 |
0 |
1115545 |
1115545 |
1.2 % |
14/02/2014 |
Visium Asset Management, LP |
United States |
0 |
1115545 |
0 |
1115545 |
1115545 |
1.2 % |
14/02/2014 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
761903 |
0 |
761903 |
761903 |
0.8 % |
14/02/2014 |
RA Capital Management, LLC |
Massachusetts |
0 |
1169898 |
0 |
1169898 |
1169898 |
1.3 % |
14/02/2014 |
Peter Kolchinsky |
United States |
0 |
1169898 |
0 |
1169898 |
1169898 |
1.3 % |
14/02/2014 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
761903 |
0 |
761903 |
761903 |
0.8 % |
14/02/2014 |
Peter Kolchinsky |
United States |
0 |
1169898 |
0 |
1169898 |
1169898 |
1.3 % |
14/02/2014 |
RA Capital Management, LLC |
Massachusetts |
0 |
1169898 |
0 |
1169898 |
1169898 |
1.3 % |
14/02/2014 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
13577670 |
0 |
13577670 |
14.942 % |
14/02/2014 |
FMR LLC |
Delaware |
21500 |
0 |
13577670 |
0 |
13577670 |
14.942 % |
14/02/2014 |
BlackRock, Inc. |
Delaware |
5322760 |
0 |
5556789 |
0 |
5556789 |
6.1 % |
28/01/2014 |
Hove, Anders |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
Roberts, Bryan |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
VHCP Holdings, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
Venrock Healthcare Capital Partners, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
VHCP Management, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
JG Asset, LLC |
United States |
0 |
4681603 |
0 |
4681603 |
4681603 |
6 % |
14/02/2013 |
Jacob Gottlieb |
United States |
0 |
4681603 |
0 |
4681603 |
4681603 |
6 % |
14/02/2013 |
Visium Asset Management, LP |
United States |
0 |
4681603 |
0 |
4681603 |
4681603 |
6 % |
14/02/2013 |
Visium Balanced Master Fund, Ltd. |
Cayman Islands |
0 |
4681603 |
0 |
4681603 |
4681603 |
6 % |
14/02/2013 |
Peter Kolchinsky |
United States |
7347878 |
0 |
7347878 |
0 |
7347878 |
9.3 % |
14/02/2013 |
RA Capital Healthcare Fund, L.P. |
Delaware |
4612741 |
0 |
4612741 |
0 |
4612741 |
5.9 % |
14/02/2013 |
RA Capital Management, LLC |
Massachusetts |
7347878 |
0 |
7347878 |
0 |
7347878 |
9.3 % |
14/02/2013 |
RA Capital Healthcare Fund, L.P. |
Delaware |
4612741 |
0 |
4612741 |
0 |
4612741 |
5.9 % |
14/02/2013 |
RA Capital Management, LLC |
Massachusetts |
7347878 |
0 |
7347878 |
0 |
7347878 |
9.3 % |
14/02/2013 |
Peter Kolchinsky |
United States |
7347878 |
0 |
7347878 |
0 |
7347878 |
9.3 % |
14/02/2013 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
9652910 |
0 |
9652910 |
12.765 % |
10/01/2013 |
FMR LLC |
Delaware |
0 |
0 |
9652910 |
0 |
9652910 |
12.765 % |
10/01/2013 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
9652910 |
0 |
9652910 |
12.765 % |
10/01/2013 |
FMR LLC |
Delaware |
0 |
0 |
9652910 |
0 |
9652910 |
12.765 % |
10/01/2013 |
JG Asset, LLC |
United States |
0 |
4681603 |
0 |
4681603 |
4681603 |
6.2 % |
21/12/2012 |
Jacob Gottlieb |
United States |
0 |
4681603 |
0 |
4681603 |
4681603 |
6.2 % |
21/12/2012 |
Jacob Gottlieb |
United States |
0 |
4681603 |
0 |
4681603 |
4681603 |
6.2 % |
21/12/2012 |
Visium Balanced Master Fund, Ltd. |
Cayman Islands |
0 |
4681603 |
0 |
4681603 |
4681603 |
6.2 % |
21/12/2012 |
Visium Asset Management, LP |
United States |
0 |
4681603 |
0 |
4681603 |
4681603 |
6.2 % |
21/12/2012 |
Visium Balanced Master Fund, Ltd. |
Cayman Islands |
0 |
4681603 |
0 |
4681603 |
4681603 |
6.2 % |
21/12/2012 |
JG Asset, LLC |
United States |
0 |
4681603 |
0 |
4681603 |
4681603 |
6.2 % |
21/12/2012 |
Visium Asset Management, LP |
United States |
0 |
4681603 |
0 |
4681603 |
4681603 |
6.2 % |
21/12/2012 |
Baker Bros. Advisors, LLC |
Delaware |
11155672 |
0 |
11155672 |
0 |
11155672 |
19.7 % |
10/12/2012 |
Julian C. Baker |
United States |
11155672 |
0 |
11155672 |
0 |
11155672 |
19.7 % |
10/12/2012 |
Felix J. Baker |
United States |
11155672 |
0 |
11155672 |
0 |
11155672 |
19.7 % |
10/12/2012 |
Baker Bros. Advisors, LLC |
Delaware |
11155672 |
0 |
11155672 |
0 |
11155672 |
19.7 % |
10/12/2012 |
Felix J. Baker |
United States |
11155672 |
0 |
11155672 |
0 |
11155672 |
19.7 % |
10/12/2012 |
Julian C. Baker |
United States |
11155672 |
0 |
11155672 |
0 |
11155672 |
19.7 % |
10/12/2012 |
Peter Kolchinsky |
United States |
5269999 |
0 |
5269999 |
0 |
5269999 |
9.98 % |
14/02/2012 |
RA Capital Management, LLC |
Massachusetts |
5269999 |
0 |
5269999 |
0 |
5269999 |
9.98 % |
14/02/2012 |
RA Capital Healthcare Fund, L.P. |
Delaware |
2657194 |
0 |
2657194 |
0 |
2657194 |
5.03 % |
14/02/2012 |
Julian C. Baker |
United States |
0 |
5567040 |
0 |
5567040 |
5567040 |
9.9 % |
14/02/2012 |
Felix J. Baker |
United States |
0 |
5567040 |
0 |
5567040 |
5567040 |
9.9 % |
14/02/2012 |
Julian C. Baker |
United States |
0 |
5567040 |
0 |
5567040 |
5567040 |
9.9 % |
14/02/2012 |
Felix J. Baker |
United States |
0 |
5567040 |
0 |
5567040 |
5567040 |
9.9 % |
14/02/2012 |
VHCP Management, LLC |
Delaware |
0 |
45235592 |
0 |
45235592 |
45235592 |
8.4 % |
14/02/2012 |
VHCP CoInvestment Holdings, LLC |
Delaware |
0 |
45235592 |
0 |
45235592 |
45235592 |
8.4 % |
14/02/2012 |
Venrock Healthcare Capital Partners, L.P. |
Delaware |
0 |
45235592 |
0 |
45235592 |
45235592 |
8.4 % |
14/02/2012 |
Roberts, Bryan |
United States |
0 |
45235592 |
0 |
45235592 |
45235592 |
8.4 % |
14/02/2012 |
Hove, Anders |
United States |
0 |
45235592 |
0 |
45235592 |
45235592 |
8.4 % |
14/02/2012 |
Wellington Management Company, LLP |
Massachusetts |
0 |
333579 |
0 |
333579 |
333579 |
0.63 % |
10/11/2011 |
Wellington Management Company, LLP |
Massachusetts |
0 |
333579 |
0 |
333579 |
333579 |
0.63 % |
10/11/2011 |
Wellington Management Company, LLP |
Massachusetts |
0 |
1907050 |
0 |
3009750 |
3009750 |
5.7 % |
12/09/2011 |
Wellington Management Company, LLP |
Massachusetts |
0 |
1907050 |
0 |
3009750 |
3009750 |
5.7 % |
12/09/2011 |
FMR LLC |
Delaware |
0 |
0 |
3018606 |
0 |
3018606 |
7.681 % |
14/02/2011 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
3018606 |
0 |
3018606 |
7.681 % |
14/02/2011 |
Wellington Management Company, LLP |
Massachusetts |
0 |
3291450 |
0 |
4547850 |
4547850 |
11.57 % |
14/02/2011 |
C. Richard Kramlich |
United States citizen |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
Growth Equity Opportunities Fund II, LLC |
Delaware |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
Ryan D. Drant |
United States citizen |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
New Enterprise Associates 13, L.P. |
Cayman Islands exempted |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
NEA Partners 13, L.P. |
Cayman Islands exempted |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
Michael James Barrett |
United States citizen |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
Peter J. Barris |
United States citizen |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
Forest Baskett |
United States citizen |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
Patrick J. Kerins |
United States citizen |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
Krishna S. Kolluri |
United States citizen |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
David M. Mott |
United States citizen |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
Scott D. Sandell |
United States citizen |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
Ravi Viswanathan |
United States citizen |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
Harry R. Weller |
United States citizen |
|
5026179 |
0 |
5026179 |
5026179 |
9.7 % |
21/01/2011 |
RA Capital Healthcare Fund, L.P. |
Delaware |
1612156 |
0 |
1612156 |
0 |
1612156 |
3.1 % |
20/01/2011 |
Peter Kolchinsky |
United States |
3224296 |
0 |
3224296 |
0 |
3224296 |
6.2 % |
20/01/2011 |
RA Capital Management, LLC |
Massachusetts |
3224296 |
0 |
3224296 |
0 |
3224296 |
6.2 % |
20/01/2011 |
RA Capital Healthcare Fund, L.P. |
Delaware |
1612156 |
0 |
1612156 |
0 |
1612156 |
3.1 % |
20/01/2011 |
Peter Kolchinsky |
United States |
3224296 |
0 |
3224296 |
0 |
3224296 |
6.2 % |
20/01/2011 |
RA Capital Management, LLC |
Massachusetts |
3224296 |
0 |
3224296 |
0 |
3224296 |
6.2 % |
20/01/2011 |
Julian C. Baker |
United States |
0 |
5243844 |
0 |
5243844 |
5243844 |
9.9 % |
18/01/2011 |
Julian C. Baker |
United States |
0 |
5243844 |
0 |
5243844 |
5243844 |
9.9 % |
18/01/2011 |
Felix J. Baker |
United States |
0 |
5243844 |
0 |
5243844 |
5243844 |
9.9 % |
18/01/2011 |
Felix J. Baker |
United States |
0 |
5243844 |
0 |
5243844 |
5243844 |
9.9 % |
18/01/2011 |
Dainippon Sumitomo Pharma America Holdings, Inc. |
Delaware |
1890422 |
0 |
1890422 |
0 |
1890422 |
4.9 % |
14/05/2010 |
Dainippon Sumitomo Pharma Co. Ltd. Not Applicable |
Osaka Japan |
1890422 |
0 |
1890422 |
0 |
1890422 |
4.9 % |
14/05/2010 |
Sepracor Inc. |
Delaware |
1890422 |
0 |
1890422 |
0 |
1890422 |
4.9 % |
14/05/2010 |
Julian C. Baker |
United States |
0 |
73299 |
0 |
73299 |
73299 |
0.2 % |
16/02/2010 |
Felix J. Baker |
United States |
0 |
73299 |
0 |
73299 |
73299 |
0.2 % |
16/02/2010 |
Felix J. Baker |
United States |
0 |
73299 |
0 |
73299 |
73299 |
0.2 % |
16/02/2010 |
Julian C. Baker |
United States |
0 |
73299 |
0 |
73299 |
73299 |
0.2 % |
16/02/2010 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
3279506 |
0 |
3279506 |
8.57 % |
16/02/2010 |
FMR LLC |
Delaware |
0 |
0 |
3279506 |
0 |
3279506 |
8.57 % |
16/02/2010 |
T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
130000 |
0 |
130000 |
0.3 % |
12/02/2010 |
Nomura International plc on behalf of Nomura Phase4 Ventures LP, Nomura Phase4 GP Limited and Nomura Phase4 Ventures Limited |
England and Wales |
0 |
0 |
0 |
0 |
0 |
1.4 % |
12/02/2010 |
S Wellington Management Company, LLP |
Massachusetts |
0 |
3899370 |
0 |
5357358 |
5357358 |
14 % |
12/02/2010 |
Delaware Management Business Trust .................................................................. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2010 |
Delaware Management Holdings .................................................................. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2010 |
BVF Investments, L.L.C. |
Delaware |
0 |
109500 |
0 |
109500 |
109500 |
0 % |
02/02/2010 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
71476 |
0 |
71476 |
71476 |
0 % |
02/02/2010 |
Investment 10, L.L.C. |
Illinois |
0 |
12000 |
0 |
12000 |
12000 |
0 % |
02/02/2010 |
BVF Partners L.P. |
Delaware |
0 |
238226 |
0 |
238226 |
238226 |
0 % |
02/02/2010 |
BVF Inc. |
Delaware |
0 |
238226 |
0 |
238226 |
238226 |
0 % |
02/02/2010 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
45250 |
0 |
45250 |
45250 |
0 % |
02/02/2010 |
Mark N. Lampert |
United States |
0 |
238226 |
0 |
238226 |
238226 |
0 % |
02/02/2010 |
mRNA FUND II L.P. |
Delaware |
0 |
|
0 |
3422717 |
3422717 |
8.9 % |
02/02/2010 |
OBP MANAGEMENT IV L.P. |
Delaware |
0 |
|
0 |
3422717 |
3422717 |
8.9 % |
02/02/2010 |
ALAN G. WALTON |
United States |
100909 |
|
100909 |
3422717 |
3523626 |
9.2 % |
02/02/2010 |
JONATHAN J. FLEMING |
United States |
0 |
|
0 |
3422717 |
3422717 |
8.9 % |
02/02/2010 |
OXFORD BIOSCIENCE PARTNERS IV L.P. |
Delaware |
0 |
|
0 |
3422717 |
3422717 |
8.9 % |
02/02/2010 |
OppenheimerFunds, Inc. |
Colorado |
0 |
0 |
0 |
0 |
0 |
0 % |
01/02/2010 |