ACRS

Aclaris Therapeutics, Inc. ACRS

Individual Beneficiary

Name of reporting person Citizenship or organization Sole voting power Shared voting power Sole dispositive power Shared dispositive power Amount beneficially owned Percent of class Accepted date
Biosion, Inc. The People’s Republic of China 11281985 0 11281985 0 11281985 9.5 % 25/11/2024
Rock Springs Capital Management LP Delaware 0 6761861 0 6761861 0 6.32 % 22/11/2024
Rock Springs Capital Master Fund LP Cayman Islands 0 5697000 0 0 0 5.32 % 22/11/2024
Rock Springs Capital LLC Delaware 0 6761861 0 6761861 0 6.32 % 22/11/2024
Vivo Opportunity Fund Holdings, L.P. Delaware 7955160 0 7955160 0 7955160 7.4 % 21/11/2024
Vivo Opportunity, LLC Delaware 7955160 0 7955160 0 7955160 7.4 % 21/11/2024
Vivo Asia Opportunity Fund Holdings, L.P. Cayman Islands 933728 0 933728 0 933728 0.9 % 21/11/2024
Vivo Opportunity Cayman, LLC Cayman Islands 933728 0 933728 0 933728 0.9 % 21/11/2024
Millennium Group Management LLC Delaware 0 3005598 0 3005598 3005598 4.2 % 09/10/2024
Millennium Management LLC Delaware 0 3005598 0 3005598 3005598 4.2 % 09/10/2024
Israel A. Englander United States 0 3005598 0 3005598 3005598 4.2 % 09/10/2024
BlackRock, Inc. Delaware 2028486 0 2032464 0 2032464 2.9 % 08/07/2024
Peter Kolchinsky United States of America 0 0 0 0 0 0 % 14/02/2024
Rajeev Shah United States of America 0 0 0 0 0 0 % 14/02/2024
RA Capital Healthcare Fund, L.P. Delaware 0 0 0 0 0 0 % 14/02/2024
RA Capital Management, L.P. Delaware 0 0 0 0 0 0 % 14/02/2024
Citadel Securities Group LP Delaware 0 1118158 0 1118158 1118158 1.6 % 14/02/2024
Kenneth Griffin U.S. Citizen 0 5406089 0 5406089 5406089 7.6 % 14/02/2024
Citadel Securities GP LLC Delaware 0 1118158 0 1118158 1118158 1.6 % 14/02/2024
Citadel Advisors LLC Delaware 0 4287931 0 4287931 4287931 6.1 % 14/02/2024
Citadel Securities LLC Delaware 0 579576 0 579576 579576 0.8 % 14/02/2024
Citadel GP LLC Delaware 0 4287931 0 4287931 4287931 6.1 % 14/02/2024
Citadel Advisors Holdings LP Delaware 0 4287931 0 4287931 4287931 6.1 % 14/02/2024
Millennium Management LLC Delaware 0 3769926 0 3769926 3769926 5.3 % 14/02/2024
Israel A. Englander United States 0 3769926 0 3769926 3769926 5.3 % 14/02/2024
Millennium Group Management LLC Delaware 0 3769926 0 3769926 3769926 5.3 % 14/02/2024
The Vanguard Group Pennsylvania 0 122961 4551152 170735 4721887 6.67 % 13/02/2024
BML Investment Partners, L.P. Delaware 0 9395934 0 9395934 9395934 13.3 % 08/02/2024
BML Investment Partners, L.P. Delaware 0 9395934 0 9395934 9395934 13.3 % 08/02/2024
Millennium Management LLC Delaware 0 3479361 0 3479361 3479361 4.9 % 01/02/2024
Millennium Management LLC Delaware 0 3479361 0 3479361 3479361 4.9 % 01/02/2024
Millennium Group Management LLC Delaware 0 3479361 0 3479361 3479361 4.9 % 01/02/2024
Israel A. Englander United States 0 3479361 0 3479361 3479361 4.9 % 01/02/2024
Millennium Group Management LLC Delaware 0 3479361 0 3479361 3479361 4.9 % 01/02/2024
Israel A. Englander United States 0 3479361 0 3479361 3479361 4.9 % 01/02/2024
BML Investment Partners, L.P. Delaware 0 4500000 0 4500000 4500000 6.4 % 16/01/2024
BML Investment Partners, L.P. Delaware 0 4500000 0 4500000 4500000 6.4 % 16/01/2024
Israel A. Englander United States 0 3588114 0 3588114 3588114 5.1 % 11/12/2023
Millennium Group Management LLC Delaware 0 3588114 0 3588114 3588114 5.1 % 11/12/2023
Millennium Management LLC Delaware 0 3588114 0 3588114 3588114 5.1 % 11/12/2023
Israel A. Englander United States 0 3588114 0 3588114 3588114 5.1 % 11/12/2023
Millennium Group Management LLC Delaware 0 3588114 0 3588114 3588114 5.1 % 11/12/2023
Millennium Management LLC Delaware 0 3588114 0 3588114 3588114 5.1 % 11/12/2023
Wellington Investment Advisors Holdings LLP Delaware 0 0 0 0 0 0 % 11/12/2023
Wellington Management Group LLP Massachusetts 0 0 0 0 0 0 % 11/12/2023
Wellington Investment Advisors Holdings LLP Delaware 0 0 0 0 0 0 % 11/12/2023
Wellington Group Holdings LLP Delaware 0 0 0 0 0 0 % 11/12/2023
Wellington Management Group LLP Massachusetts 0 0 0 0 0 0 % 11/12/2023
Wellington Group Holdings LLP Delaware 0 0 0 0 0 0 % 11/12/2023
TANG CAPITAL PARTNERS, LP DELAWARE 4338155 0 4338155 4338155 6.1 % 24/11/2023
Kevin Tang united states 4338155 0 4338155 4338155 6.1 % 24/11/2023
Tang Capital Management, LLC DELAWARE 4338155 0 4338155 4338155 6.1 % 24/11/2023
TANG CAPITAL PARTNERS, LP DELAWARE 4338155 0 4338155 4338155 6.1 % 24/11/2023
Kevin Tang united states 4338155 0 4338155 4338155 6.1 % 24/11/2023
Tang Capital Management, LLC DELAWARE 4338155 0 4338155 4338155 6.1 % 24/11/2023
Citadel GP LLC Delaware 0 3317794 0 3317794 3317794 4.7 % 05/09/2023
Citadel Securities LLC Delaware 0 268970 0 268970 268970 0.4 % 05/09/2023
Citadel Securities Group LP Delaware 0 268970 0 268970 268970 0.4 % 05/09/2023
Citadel Securities GP LLC Delaware 0 268970 0 268970 268970 0.4 % 05/09/2023
Citadel Advisors Holdings LP Delaware 0 3317794 0 3317794 3317794 4.7 % 05/09/2023
Citadel Advisors LLC Delaware 0 3317794 0 3317794 3317794 4.7 % 05/09/2023
Kenneth Griffin U.S. Citizen 0 3586764 0 3586764 3586764 5.1 % 05/09/2023
Wellington Management Group LLP Massachusetts 0 6205780 0 7372601 7372601 11.05 % 10/04/2023
Wellington Management Company LLP Delaware 0 6098335 0 6853900 6853900 10.28 % 10/04/2023
Wellington Management Company LLP Delaware 0 6098335 0 6853900 6853900 10.28 % 10/04/2023
Wellington Investment Advisors Holdings LLP Delaware 0 6205780 0 7372601 7372601 11.05 % 10/04/2023
Wellington Investment Advisors Holdings LLP Delaware 0 6205780 0 7372601 7372601 11.05 % 10/04/2023
Wellington Group Holdings LLP Delaware 0 6205780 0 7372601 7372601 11.05 % 10/04/2023
Wellington Management Group LLP Massachusetts 0 6205780 0 7372601 7372601 11.05 % 10/04/2023
Wellington Group Holdings LLP Delaware 0 6205780 0 7372601 7372601 11.05 % 10/04/2023
Biotechnology Value Trading Fund OS LP Cayman Islands 0 156083 0 156083 156083 0 % 16/03/2023
BVF Inc. Delaware 0 3360941 0 3360941 3360941 5 % 16/03/2023
BVF Partners L.P. Delaware 0 3360941 0 3360941 3360941 5 % 16/03/2023
BVF Partners OS Ltd. Cayman Islands 0 156083 0 156083 156083 0 % 16/03/2023
BVF GP Holdings LLC Delaware 0 3158204 0 3158204 3158204 4.7 % 16/03/2023
BVF Partners L.P. Delaware 0 3360941 0 3360941 3360941 5 % 16/03/2023
BVF Inc. Delaware 0 3360941 0 3360941 3360941 5 % 16/03/2023
Mark N. Lampert United States 0 3360941 0 3360941 3360941 5 % 16/03/2023
BVF Partners OS Ltd. Cayman Islands 0 156083 0 156083 156083 0 % 16/03/2023
Biotechnology Value Trading Fund OS LP Cayman Islands 0 156083 0 156083 156083 0 % 16/03/2023
Biotechnology Value Fund II, L.P. Delaware 0 1363323 0 1363323 1363323 2 % 16/03/2023
BVF II GP LLC Delaware 0 1363323 0 1363323 1363323 2 % 16/03/2023
BVF I GP LLC Delaware 0 1794881 0 1794881 1794881 2.7 % 16/03/2023
Biotechnology Value Fund, L.P. Delaware 0 1794881 0 1794881 1794881 2.7 % 16/03/2023
Mark N. Lampert United States 0 3360941 0 3360941 3360941 5 % 16/03/2023
BVF GP Holdings LLC Delaware 0 3158204 0 3158204 3158204 4.7 % 16/03/2023
Biotechnology Value Fund II, L.P. Delaware 0 1363323 0 1363323 1363323 2 % 16/03/2023
BVF II GP LLC Delaware 0 1363323 0 1363323 1363323 2 % 16/03/2023
Biotechnology Value Fund, L.P. Delaware 0 1794881 0 1794881 1794881 2.7 % 16/03/2023
BVF I GP LLC Delaware 0 1794881 0 1794881 1794881 2.7 % 16/03/2023
Foresite Capital Fund V, L.P. (“FCF V”) 1258243 1258243 1.9 % 13/02/2023
James Tananbaum (“Tananbaum”) 4066277 4066277 6.1 % 13/02/2023
Foresite Capital Fund IV, L.P. (“FCF IV”) 2808034 2808034 4.2 % 13/02/2023
Foresite Capital Management IV, LLC (“FCM IV”) 2808034 2808034 4.2 % 13/02/2023
Foresite Capital Management V, LLC (“FCM V”) 1258243 1.9 % 13/02/2023
Foresite Capital Fund V, L.P. (“FCF V”) 1258243 1258243 1.9 % 13/02/2023
James Tananbaum (“Tananbaum”) 4066277 4066277 6.1 % 13/02/2023
Foresite Capital Management V, LLC (“FCM V”) 1258243 1.9 % 13/02/2023
Foresite Capital Fund IV, L.P. (“FCF IV”) 2808034 2808034 4.2 % 13/02/2023
Foresite Capital Management IV, LLC (“FCM IV”) 2808034 2808034 4.2 % 13/02/2023
BlackRock, Inc. Delaware 4966317 0 5087435 0 5087435 7.6 % 31/01/2023
Peter Kolchinsky United States of America 0 4398453 0 4398453 4398453 7.1 % 25/04/2022
Rajeev Shah United States of America 0 4398453 0 4398453 4398453 7.1 % 25/04/2022
RA Capital Healthcare Fund, L.P. Delaware 0 4398453 0 4398453 4398453 7.1 % 25/04/2022
RA Capital Management, L.P. Delaware 0 4398453 0 4398453 4398453 7.1 % 25/04/2022
Peter Kolchinsky United States of America 0 4398453 0 4398453 4398453 7.1 % 25/04/2022
Rajeev Shah United States of America 0 4398453 0 4398453 4398453 7.1 % 25/04/2022
RA Capital Healthcare Fund, L.P. Delaware 0 4398453 0 4398453 4398453 7.1 % 25/04/2022
RA Capital Management, L.P. Delaware 0 4398453 0 4398453 4398453 7.1 % 25/04/2022
Foresite Capital Fund V, L.P. (“FCF V”) 1258243 1258243 2.1 % 11/02/2022
Foresite Capital Fund IV, L.P. (“FCF IV”) 3399034 3399034 5.6 % 11/02/2022
Foresite Capital Management IV, LLC (“FCM IV”) 3399034 5.6 % 11/02/2022
James Tananbaum (“Tananbaum”) 4657277 4657277 7.6 % 11/02/2022
Foresite Capital Management III, LLC (“FCM III”) 0 0 0 % 11/02/2022
Foresite Capital Management V, LLC (“FCM V”) 1258243 1258243 2.1 % 11/02/2022
Foresite Capital Fund III, L.P. (“FCF III”) 0 0 0 % 11/02/2022
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 1676878 0 1676878 0 1676878 2.74 % 10/02/2022
Renaissance Technologies LLC Delaware 1676878 0 1676878 0 1676878 2.74 % 10/02/2022
Renaissance Technologies LLC Delaware 1676878 0 1676878 0 1676878 2.74 % 10/02/2022
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 1676878 0 1676878 0 1676878 2.74 % 10/02/2022
BlackRock, Inc. Delaware 3967037 0 4078875 0 4078875 6.7 % 04/02/2022
BVF Partners L.P. Delaware 0 3868043 0 3868043 3868043 6.3 % 24/01/2022
BVF Inc. Delaware 0 3868043 0 3868043 3868043 6.3 % 24/01/2022
Mark N. Lampert United States 0 3868043 0 3868043 3868043 6.3 % 24/01/2022
Biotechnology Value Trading Fund OS LP Cayman Islands 0 189520 0 189520 189520 0 % 24/01/2022
BVF Partners OS Ltd. Cayman Islands 0 189520 0 189520 189520 0 % 24/01/2022
Mark N. Lampert United States 0 3868043 0 3868043 3868043 6.3 % 24/01/2022
BVF Inc. Delaware 0 3868043 0 3868043 3868043 6.3 % 24/01/2022
BVF GP HOLDINGS LLC Delaware 0 3616055 0 3616055 3616055 5.9 % 24/01/2022
BVF Partners L.P. Delaware 0 3868043 0 3868043 3868043 6.3 % 24/01/2022
Biotechnology Value Fund, L.P. Delaware 0 2093085 0 2093085 2093085 3.4 % 24/01/2022
BVF I GP LLC Delaware 0 2093085 0 2093085 2093085 3.4 % 24/01/2022
Biotechnology Value Fund II, L.P. Delaware 0 1522970 0 1522970 1522970 2.5 % 24/01/2022
BVF II GP LLC Delaware 0 1522970 0 1522970 1522970 2.5 % 24/01/2022
Biotechnology Value Fund, L.P. Delaware 0 2093085 0 2093085 2093085 3.4 % 24/01/2022
BVF I GP LLC Delaware 0 2093085 0 2093085 2093085 3.4 % 24/01/2022
Biotechnology Value Fund II, L.P. Delaware 0 1522970 0 1522970 1522970 2.5 % 24/01/2022
BVF II GP LLC Delaware 0 1522970 0 1522970 1522970 2.5 % 24/01/2022
Biotechnology Value Trading Fund OS LP Cayman Islands 0 189520 0 189520 189520 0 % 24/01/2022
BVF Partners OS Ltd. Cayman Islands 0 189520 0 189520 189520 0 % 24/01/2022
BVF GP HOLDINGS LLC Delaware 0 3616055 0 3616055 3616055 5.9 % 24/01/2022
Rock Springs Capital Master Fund LP Cayman Islands 0 2600000 0 2600000 2600000 6.06 % 16/02/2021
Rock Springs Capital Master Fund LP Cayman Islands 0 2600000 0 2600000 0 6.06 % 16/02/2021
Rock Springs Capital LLC Delaware 0 2676100 0 2676100 0 6.24 % 16/02/2021
Rock Springs Capital Management LP Delaware 0 2676100 0 2676100 0 6.24 % 16/02/2021
Rock Springs Capital Management LP Delaware 0 2676100 0 2676100 2676100 6.24 % 16/02/2021
Rock Springs Capital LLC Delaware 0 2676100 0 2676100 2676100 6.24 % 16/02/2021
Foresite Capital Fund III, L.P. (“FCF III”) 1954904 1954904 0 % 11/02/2021
Foresite Capital Fund V, L.P. (“FCF V”) 1258243 2.6 % 11/02/2021
Foresite Capital Management IV, LLC (“FCM IV”) 3399034 7 % 11/02/2021
Foresite Capital Management III, LLC (“FCM III”) 1954904 0 % 11/02/2021
Foresite Capital Fund III, L.P. (“FCF III”) 1954904 1954904 0 % 11/02/2021
James Tananbaum (“Tananbaum”) 6612181 0 % 11/02/2021
Foresite Capital Management V, LLC (“FCM V”) 1258243 1258243 2.6 % 11/02/2021
Foresite Capital Fund IV, L.P. (“FCF IV”) 3399034 0 % 11/02/2021
James Tananbaum (“Tananbaum”) 6612181 0 % 11/02/2021
Foresite Capital Management V, LLC (“FCM V”) 1258243 1258243 2.6 % 11/02/2021
Foresite Capital Fund V, L.P. (“FCF V”) 1258243 2.6 % 11/02/2021
Foresite Capital Management IV, LLC (“FCM IV”) 3399034 7 % 11/02/2021
Foresite Capital Fund IV, L.P. (“FCF IV”) 3399034 0 % 11/02/2021
Foresite Capital Management III, LLC (“FCM III”) 1954904 0 % 11/02/2021
Adage Capital Partners, L.P. Delaware 0 2250000 0 2250000 2250000 5.24 % 11/02/2021
Adage Capital Advisors, L.L.C. Delaware 0 2250000 0 2250000 2250000 5.24 % 11/02/2021
Adage Capital Partners GP, L.L.C. Delaware 0 2250000 0 2250000 2250000 5.24 % 11/02/2021
Robert Atchinson United States 0 2250000 0 2250000 2250000 5.24 % 11/02/2021
Phillip Gross United States 0 2250000 0 2250000 2250000 5.24 % 11/02/2021
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 3268178 0 3268178 0 3268178 7.61 % 10/02/2021
Renaissance Technologies LLC Delaware 3268178 0 3268178 0 3268178 7.61 % 10/02/2021
Renaissance Technologies LLC Delaware 3268178 0 3268178 0 3268178 7.61 % 10/02/2021
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 3268178 0 3268178 0 3268178 7.61 % 10/02/2021
Foresite Capital Management IV, LLC (“FCM IV”) Delaware 610696 610696 610696 610696 610696 1.4 % 26/10/2020
James Tananbaum (“Tananbaum”) United States 2230940 2230940 2230940 2230940 2230940 5.2 % 26/10/2020
Foresite Capital Fund IV, L.P. (“FCF IV”) Delaware 610696 610696 610696 610696 610696 1.4 % 26/10/2020
Foresite Capital Management III, LLC (“FCM III”) Delaware 1620244 1620244 1620244 1620244 1620244 3.8 % 26/10/2020
Foresite Capital Fund III, L.P. (“FCF III”) Delaware 1620244 1620244 1620244 1620244 1620244 3.8 % 26/10/2020
Foresite Capital Management IV, LLC (“FCM IV”) Delaware 610696 610696 610696 610696 610696 1.4 % 26/10/2020
Foresite Capital Fund IV, L.P. (“FCF IV”) Delaware 610696 610696 610696 610696 610696 1.4 % 26/10/2020
Foresite Capital Management III, LLC (“FCM III”) Delaware 1620244 1620244 1620244 1620244 1620244 3.8 % 26/10/2020
Foresite Capital Fund III, L.P. (“FCF III”) Delaware 1620244 1620244 1620244 1620244 1620244 3.8 % 26/10/2020
James Tananbaum (“Tananbaum”) United States 2230940 2230940 2230940 2230940 2230940 5.2 % 26/10/2020
Rock Springs Capital Management LP Delaware 0 2213856 0 2213856 0 5.18 % 26/10/2020
Rock Springs Capital Master Fund LP Cayman Islands 0 2150000 0 2150000 0 5.03 % 26/10/2020
Rock Springs Capital LLC Delaware 0 2213856 0 2213856 0 5.18 % 26/10/2020
Rock Springs Capital Management LP Delaware 0 2213856 0 2213856 0 5.18 % 26/10/2020
Rock Springs Capital LLC Delaware 0 2213856 0 2213856 0 5.18 % 26/10/2020
Rock Springs Capital Master Fund LP Cayman Islands 0 2150000 0 2150000 0 5.03 % 26/10/2020
MFN Partners GP, LLC Delaware 1895677 0 1895677 0 1895677 4.53 % 22/07/2020
Michael DeMichele United States 1895677 0 1895677 0 1895677 4.53 % 22/07/2020
Farhad Nanji Canada 1895677 0 1895677 0 1895677 4.53 % 22/07/2020
MFN Partners Management, LLC Delaware 1895677 0 1895677 0 1895677 4.53 % 22/07/2020
MFN Partners Management, LP Delaware 1895677 0 1895677 0 1895677 4.53 % 22/07/2020
MFN Partners GP, LLC Delaware 1895677 0 1895677 0 1895677 4.53 % 22/07/2020
MFN Partners, LP Delaware 1895677 0 1895677 0 1895677 4.53 % 22/07/2020
Michael DeMichele United States 1895677 0 1895677 0 1895677 4.53 % 22/07/2020
Farhad Nanji Canada 1895677 0 1895677 0 1895677 4.53 % 22/07/2020
MFN Partners Management, LLC Delaware 1895677 0 1895677 0 1895677 4.53 % 22/07/2020
MFN Partners Management, LP Delaware 1895677 0 1895677 0 1895677 4.53 % 22/07/2020
MFN Partners, LP Delaware 1895677 0 1895677 0 1895677 4.53 % 22/07/2020
Adage Capital Advisors, L.L.C. Delaware 0 2500000 0 2500000 2500000 5.97 % 26/06/2020
Adage Capital Partners GP, L.L.C. Delaware 0 2500000 0 2500000 2500000 5.97 % 26/06/2020
Adage Capital Advisors, L.L.C. Delaware 0 2500000 0 2500000 2500000 5.97 % 26/06/2020
Robert Atchinson United States 0 2500000 0 2500000 2500000 5.97 % 26/06/2020
Phillip Gross United States 0 2500000 0 2500000 2500000 5.97 % 26/06/2020
Phillip Gross United States 0 2500000 0 2500000 2500000 5.97 % 26/06/2020
Adage Capital Partners GP, L.L.C. Delaware 0 2500000 0 2500000 2500000 5.97 % 26/06/2020
Adage Capital Partners, L.P. Delaware 0 2500000 0 2500000 2500000 5.97 % 26/06/2020
Adage Capital Partners, L.P. Delaware 0 2500000 0 2500000 2500000 5.97 % 26/06/2020
Robert Atchinson United States 0 2500000 0 2500000 2500000 5.97 % 26/06/2020
Morgan Stanley Capital Services LLC Delaware. 0 0 0 0 0 0 % 09/03/2020
Morgan Stanley Delaware. 0 22428 0 23767 23767 0.1 % 09/03/2020
Samsara BioCapital, L.P. Delaware 0 2161333 0 2161333 2161333 5.2 % 06/03/2020
Samsara BioCapital GP, LLC Delaware 0 2161333 0 2161333 2161333 5.2 % 06/03/2020
Srinivas Akkaraju United States of America 0 2161333 0 2161333 2161333 5.2 % 06/03/2020
Samsara BioCapital GP, LLC Delaware 0 2161333 0 2161333 2161333 5.2 % 06/03/2020
Samsara BioCapital, L.P. Delaware 0 2161333 0 2161333 2161333 5.2 % 06/03/2020
Srinivas Akkaraju United States of America 0 2161333 0 2161333 2161333 5.2 % 06/03/2020
D. E. Shaw & Co., L.P. Delaware 0 70501 0 70501 70501 0.2 % 14/02/2020
David E. Shaw United States 0 70501 0 70501 70501 0.2 % 14/02/2020
D. E. Shaw & Co., L.L.C. Delaware 0 69769 0 69769 69769 0.2 % 14/02/2020
David E. Shaw United States 0 70501 0 70501 70501 0.2 % 14/02/2020
D. E. Shaw & Co., L.P. Delaware 0 70501 0 70501 70501 0.2 % 14/02/2020
D. E. Shaw & Co., L.L.C. Delaware 0 69769 0 69769 69769 0.2 % 14/02/2020
Oleg Nodelman United States 0 2087312 0 2087312 2087312 5 % 14/02/2020
EcoR1 Capital, LLC Delaware 0 2087312 0 2087312 2087312 5 % 14/02/2020
Kevin Kotler United States of America 0 1888039 0 1888039 1888039 4.56 % 13/02/2020
Broadfin Capital, LLC Delaware 0 1888039 0 1888039 1888039 4.56 % 13/02/2020
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 1888039 0 1888039 1888039 4.56 % 13/02/2020
Broadfin Capital, LLC Delaware 0 1888039 0 1888039 1888039 4.56 % 13/02/2020
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 1888039 0 1888039 1888039 4.56 % 13/02/2020
Kevin Kotler United States of America 0 1888039 0 1888039 1888039 4.56 % 13/02/2020
Deerfield Mgmt, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
Deerfield Partners, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
Deerfield Special Situations Fund, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
James E. Flynn United States 0 0 0 0 0 0 % 13/02/2020
Deerfield Management Company, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
Deerfield Mgmt, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
James E. Flynn United States 0 0 0 0 0 0 % 13/02/2020
Deerfield Special Situations Fund, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
Deerfield Partners, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
Deerfield Management Company, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
Morgan Stanley Delaware. 0 2516167 0 2518882 2518882 6.1 % 13/02/2020
Morgan Stanley Capital Services LLC Delaware. 0 2474895 0 2474895 2474895 6 % 13/02/2020
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 2782297 0 2782297 0 2782297 6.72 % 12/02/2020
RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION Delaware 2782297 0 2782297 0 2782297 6.72 % 12/02/2020
Renaissance Technologies LLC Delaware 2782297 0 2782297 0 2782297 6.72 % 12/02/2020
Renaissance Technologies LLC Delaware 2782297 0 2782297 0 2782297 6.72 % 12/02/2020
GLG PARTNERS LP United Kingdom 0 1295966 0 1295966 1295966 3.13 % 10/02/2020
MAN GROUP PLC Jersey 0 1295966 0 1295966 1295966 3.13 % 10/02/2020
Abigail P. Johnson United States of America 0 0 205984 0 205984 0.497 % 07/02/2020
FMR LLC Delaware 205984 0 205984 0 205984 0.497 % 07/02/2020
Abigail P. Johnson United States of America 0 0 205984 0 205984 0.497 % 07/02/2020
FMR LLC Delaware 205984 0 205984 0 205984 0.497 % 07/02/2020
MFN Partners, LP Delaware 4000000 0 4000000 0 4000000 9.7 % 31/10/2019
MFN Partners Management, LLC Delaware 4000000 0 4000000 0 4000000 9.7 % 31/10/2019
MFN Partners Management, LP Delaware 4000000 0 4000000 0 4000000 9.7 % 31/10/2019
MFN Partners GP, LLC Delaware 4000000 0 4000000 0 4000000 9.7 % 31/10/2019
Michael DeMichele United States 4000000 0 4000000 0 4000000 9.7 % 31/10/2019
Farhad Nanji Canada 4000000 0 4000000 0 4000000 9.7 % 31/10/2019
MFN Partners Management, LLC Delaware 4000000 0 4000000 0 4000000 9.7 % 31/10/2019
MFN Partners, LP Delaware 4000000 0 4000000 0 4000000 9.7 % 31/10/2019
Michael DeMichele United States 4000000 0 4000000 0 4000000 9.7 % 31/10/2019
MFN Partners Management, LP Delaware 4000000 0 4000000 0 4000000 9.7 % 31/10/2019
MFN Partners GP, LLC Delaware 4000000 0 4000000 0 4000000 9.7 % 31/10/2019
Farhad Nanji Canada 4000000 0 4000000 0 4000000 9.7 % 31/10/2019
Morgan Stanley Delaware. 2067427 0 2077242 2077242 5 % 29/08/2019
James E. Flynn United States 0 2848374 0 2848374 2848374 6.9 % 31/07/2019
James E. Flynn United States 0 2848374 0 2848374 2848374 6.9 % 31/07/2019
Deerfield Special Situations Fund, L.P. Delaware 0 766026 0 766026 766026 1.86 % 31/07/2019
Deerfield Partners, L.P. Delaware 0 2082348 0 2082348 2082348 5.05 % 31/07/2019
Deerfield Management Company, L.P. Delaware 0 2848374 0 2848374 2848374 6.9 % 31/07/2019
Deerfield Mgmt, L.P. Delaware 0 2848374 0 2848374 2848374 6.9 % 31/07/2019
Deerfield Special Situations Fund, L.P. Delaware 0 766026 0 766026 766026 1.86 % 31/07/2019
Deerfield Partners, L.P. Delaware 0 2082348 0 2082348 2082348 5.05 % 31/07/2019
Deerfield Management Company, L.P. Delaware 0 2848374 0 2848374 2848374 6.9 % 31/07/2019
Deerfield Mgmt, L.P. Delaware 0 2848374 0 2848374 2848374 6.9 % 31/07/2019
Rock Springs Capital Management LP Delaware 0 2100000 0 2100000 0 5.09 % 29/07/2019
Rock Springs Capital Master Fund LP Cayman Islands 0 2100000 0 2100000 0 5.09 % 29/07/2019
Rock Springs Capital LLC Delaware 0 2100000 0 2100000 0 5.09 % 29/07/2019
Rock Springs Capital Management LP Delaware 0 2100000 0 2100000 0 5.09 % 29/07/2019
Rock Springs Capital Master Fund LP Cayman Islands 0 2100000 0 2100000 0 5.09 % 29/07/2019
Rock Springs Capital LLC Delaware 0 2100000 0 2100000 0 5.09 % 29/07/2019
MAN GROUP PLC Jersey 0 2421185 0 2421185 2421185 5.87 % 09/07/2019
GLG PARTNERS LP United Kingdom 0 2421185 0 2421185 2421185 5.87 % 09/07/2019
MAN GROUP PLC Jersey 0 2421185 0 2421185 2421185 5.87 % 09/07/2019
GLG PARTNERS LP United Kingdom 0 2421185 0 2421185 2421185 5.87 % 09/07/2019
David E. Shaw United States 0 2280294 0 2280294 2280294 5.6 % 14/02/2019
D. E. Shaw & Co., L.L.C. Delaware 0 2278364 0 2278364 2278364 5.6 % 14/02/2019
D. E. Shaw & Co., L.P. Delaware 0 2280294 0 2280294 2280294 5.6 % 14/02/2019
S Deerfield Management Company, L.P. Delaware 0 5893416 0 5893416 5893416 14.4 % 12/02/2019
S James E. Flynn United States 0 5893416 0 5893416 5893416 14.4 % 12/02/2019
S Deerfield Mgmt, L.P. Delaware 0 5893416 0 5893416 5893416 14.4 % 12/02/2019
S Deerfield Special Situations Fund, L.P. Delaware 0 1411628 0 1411628 1411628 3.45 % 12/02/2019
S Deerfield Partners, L.P. Delaware 0 4481788 0 4481788 4481788 10.95 % 12/02/2019
BlackRock, Inc. Delaware 3435339 0 3620835 0 3620835 8.8 % 04/02/2019
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 2280260 0 2280260 2280260 5.57 % 29/01/2019
Kevin Kotler United States of America 0 2280260 0 2280260 2280260 5.57 % 29/01/2019
Kevin Kotler United States of America 0 2280260 0 2280260 2280260 5.57 % 29/01/2019
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 2280260 0 2280260 2280260 5.57 % 29/01/2019
Broadfin Capital, LLC Delaware 0 2280260 0 2280260 2280260 5.57 % 29/01/2019
Broadfin Capital, LLC Delaware 0 2280260 0 2280260 2280260 5.57 % 29/01/2019
Franklin Resources, Inc. Delaware 4 4 4 4 3986422 9.7 % 25/01/2019
Rupert H. Johnson, Jr. USA 4 4 4 4 3986422 9.7 % 25/01/2019
Franklin Advisers, Inc. California 3953203 0 3953203 0 3953203 9.7 % 25/01/2019
Charles B. Johnson USA 4 4 4 4 3986422 9.7 % 25/01/2019
FMR LLC Delaware 1369409 0 2242447 0 2242447 5.477 % 10/12/2018
FMR LLC Delaware 1369409 0 2242447 0 2242447 5.477 % 10/12/2018
Abigail P. Johnson United States of America 0 0 2242447 0 2242447 5.477 % 10/12/2018
Abigail P. Johnson United States of America 0 0 2242447 0 2242447 5.477 % 10/12/2018
D. E. Shaw & Co., L.L.C. Delaware 0 2049462 0 2049462 2049462 5 % 01/11/2018
D. E. Shaw & Co., L.P. Delaware 0 2049462 0 2049462 2049462 5 % 01/11/2018
David E. Shaw United States 0 2049462 0 2049462 2049462 5 % 01/11/2018
D. E. Shaw & Co., L.L.C. Delaware 0 2049462 0 2049462 2049462 5 % 01/11/2018
D. E. Shaw & Co., L.P. Delaware 0 2049462 0 2049462 2049462 5 % 01/11/2018
David E. Shaw United States 0 2049462 0 2049462 2049462 5 % 01/11/2018
Deerfield Special Situations Fund, L.P. Delaware 0 1411628 0 1411628 1411628 3.45 % 24/10/2018
Deerfield Partners, L.P. Delaware 0 4481788 0 4481788 4481788 10.96 % 24/10/2018
Deerfield Management Company, L.P. Delaware 0 5893416 0 5893416 5893416 14.41 % 24/10/2018
Deerfield Mgmt, L.P. Delaware 0 5893416 0 5893416 5893416 14.41 % 24/10/2018
James E. Flynn United States 0 5893416 0 5893416 5893416 14.41 % 24/10/2018
Deerfield International Master Fund, L.P. British Virgin Islands 0 0 0 0 0 0 % 24/10/2018
Deerfield Special Situations Fund, L.P. Delaware 0 1411628 0 1411628 1411628 3.45 % 24/10/2018
Deerfield Partners, L.P. Delaware 0 4481788 0 4481788 4481788 10.96 % 24/10/2018
Deerfield Management Company, L.P. Delaware 0 5893416 0 5893416 5893416 14.41 % 24/10/2018
Deerfield Mgmt, L.P. Delaware 0 5893416 0 5893416 5893416 14.41 % 24/10/2018
James E. Flynn United States 0 5893416 0 5893416 5893416 14.41 % 24/10/2018
Deerfield International Master Fund, L.P. British Virgin Islands 0 0 0 0 0 0 % 24/10/2018
Abigail P. Johnson United States of America 0 0 3355784 0 3355784 10.858 % 10/07/2018
FMR LLC Delaware 1129744 0 3355784 0 3355784 10.858 % 10/07/2018
Franklin Advisers, Inc. California 3138533 0 3138533 0 3138533 10.2 % 07/06/2018
Franklin Resources, Inc. Delaware 4 4 4 4 3164352 10.2 % 07/06/2018
Charles B. Johnson USA 4 4 4 4 3164352 10.2 % 07/06/2018
Rupert H. Johnson, Jr. USA 4 4 4 4 3164352 10.2 % 07/06/2018
FMR LLC Delaware 999811 0 2573656 0 2573656 8.346 % 12/03/2018
FMR LLC Delaware 999811 0 2573656 0 2573656 8.346 % 12/03/2018
Abigail P. Johnson United States of America 0 0 2573656 0 2573656 8.346 % 12/03/2018
Abigail P. Johnson United States of America 0 0 2573656 0 2573656 8.346 % 12/03/2018
S Deerfield Management Company, L.P. Delaware 0 2233416 0 2233416 2233416 7.24 % 14/02/2018
S Deerfield Mgmt, L.P. Delaware 0 2233416 0 2233416 2233416 7.24 % 14/02/2018
S James E. Flynn United States 0 2233416 0 2233416 2233416 7.24 % 14/02/2018
S Deerfield International Master Fund, L.P. British Virgin Islands 0 768128 0 768128 768128 2.49 % 14/02/2018
S Deerfield Special Situations Fund, L.P. Delaware 0 57416 0 57416 57416 0.19 % 14/02/2018
S Deerfield Partners, L.P. Delaware 0 1407872 0 1407872 1407872 4.57 % 14/02/2018
Abigail P. Johnson United States of America 0 0 2673260 0 2673260 8.669 % 13/02/2018
FMR LLC Delaware 1091875 0 2673260 0 2673260 8.669 % 13/02/2018
Abigail P. Johnson United States of America 0 0 2673260 0 2673260 8.669 % 13/02/2018
FMR LLC Delaware 1091875 0 2673260 0 2673260 8.669 % 13/02/2018
Franklin Advisers, Inc. California 2579414 0 2579414 0 2579414 8.4 % 05/02/2018
Rupert H. Johnson, Jr. USA 4 4 4 4 2596814 8.4 % 05/02/2018
Charles B. Johnson USA 4 4 4 4 2596814 8.4 % 05/02/2018
Franklin Resources, Inc. Delaware 4 4 4 4 2596814 8.4 % 05/02/2018
BlackRock, Inc. Delaware 2143825 0 2195028 0 2195028 7.1 % 01/02/2018
Deerfield Mgmt, L.P. Delaware 0 1769377 0 1769377 1769377 5.9 % 10/10/2017
Deerfield Mgmt, L.P. Delaware 0 1769377 0 1769377 1769377 5.9 % 10/10/2017
Deerfield Management Company, L.P. Delaware 0 1769377 0 1769377 1769377 5.9 % 10/10/2017
Deerfield Partners, L.P. Delaware 0 1107639 0 1107639 1107639 3.69 % 10/10/2017
Deerfield Special Situations Fund, L.P. Delaware 0 57416 0 57416 57416 0.19 % 10/10/2017
Deerfield International Master Fund, L.P. British Virgin Islands 0 604322 0 604322 604322 2.01 % 10/10/2017
James E. Flynn United States 0 1769377 0 1769377 1769377 5.9 % 10/10/2017
Deerfield Management Company, L.P. Delaware 0 1769377 0 1769377 1769377 5.9 % 10/10/2017
Deerfield Partners, L.P. Delaware 0 1107639 0 1107639 1107639 3.69 % 10/10/2017
Deerfield Special Situations Fund, L.P. Delaware 0 57416 0 57416 57416 0.19 % 10/10/2017
Deerfield International Master Fund, L.P. British Virgin Islands 0 604322 0 604322 604322 2.01 % 10/10/2017
James E. Flynn United States 0 1769377 0 1769377 1769377 5.9 % 10/10/2017
Abigail P. Johnson United States of America 0 0 3114457 0 3114457 10.382 % 15/08/2017
FMR LLC Delaware 1000018 0 3114457 0 3114457 10.382 % 15/08/2017
Abigail P. Johnson United States of America 0 0 3114457 0 3114457 10.382 % 15/08/2017
FMR LLC Delaware 1000018 0 3114457 0 3114457 10.382 % 15/08/2017
RA Capital Management, LLC Massachusetts 0 0 0 0 0 0 % 14/02/2017
RA Capital Healthcare Fund, L.P. Delaware 0 0 0 0 0 0 % 14/02/2017
Peter Kolchinsky United States 0 0 0 0 0 0 % 14/02/2017
s Perceptive Advisors LLC Delaware United States America 0 1260847 0 1260847 1260847 5.88 % 14/02/2017
s Perceptive Life Sciences Master Fund, Ltd. Cayman Islands 0 1194653 0 1194653 1194653 5.57 % 14/02/2017
s Joseph Edelman United States America 0 1260847 0 1260847 1260847 5.88 % 14/02/2017
Franklin Advisers, Inc. California 1516849 0 1516849 0 1516849 5.8 % 08/02/2017
Rupert H. Johnson, Jr. USA 4 4 4 4 1527549 5.9 % 08/02/2017
Charles B. Johnson USA 4 4 4 4 1527549 5.9 % 08/02/2017
Franklin Resources, Inc. Delaware 4 4 4 4 1527549 5.9 % 08/02/2017
Abigail P. Johnson United States of America 0 0 1931727 0 1931727 7.598 % 21/12/2016
FMR LLC Delaware 1931727 0 1931727 0 1931727 7.598 % 21/12/2016
Abigail P. Johnson United States of America 0 0 1931727 0 1931727 7.598 % 21/12/2016
FMR LLC Delaware 1931727 0 1931727 0 1931727 7.598 % 21/12/2016
RA Capital Management, LLC Massachusetts 0 1530020 0 1530020 1530020 7.1 % 06/10/2016
RA Capital Healthcare Fund, L.P. Delaware 0 1304714 0 1304714 1304714 6.1 % 06/10/2016
Peter Kolchinsky United States 0 1530020 0 1530020 1530020 7.1 % 06/10/2016
RA Capital Healthcare Fund, L.P. Delaware 0 1304714 0 1304714 1304714 6.1 % 06/10/2016
RA Capital Management, LLC Massachusetts 0 1530020 0 1530020 1530020 7.1 % 06/10/2016
Peter Kolchinsky United States 0 1530020 0 1530020 1530020 7.1 % 06/10/2016
Abigail P. Johnson United States of America 0 0 2789898 0 2789898 13.84 % 21/04/2016
FMR LLC Delaware 2789898 0 2789898 0 2789898 13.84 % 21/04/2016
FMR LLC Delaware 2789898 0 2789898 0 2789898 13.84 % 21/04/2016
Abigail P. Johnson United States of America 0 0 2789898 0 2789898 13.84 % 21/04/2016
RA Capital Management, LLC Massachusetts 0 2564553 0 2564553 2564553 12.7 % 16/02/2016
RA Capital Healthcare Fund, L.P. Delaware 0 2146914 0 2146914 2146914 10.7 % 16/02/2016
Peter Kolchinsky United States 0 2564553 0 2564553 2564553 12.7 % 16/02/2016
Rupert H. Johnson, Jr. USA 4 4 4 4 1654894 8.2 % 03/02/2016
Franklin Resources, Inc. Delaware 4 4 4 4 1654894 8.2 % 03/02/2016
Franklin Advisers, Inc. California 1642894 0 1642894 0 1642894 8.2 % 03/02/2016
Charles B. Johnson USA 4 4 4 4 1654894 8.2 % 03/02/2016
Abigail P. Johnson United States of America 0 0 3804279 0 3804279 19.602 % 14/10/2015
Abigail P. Johnson United States of America 0 0 3804279 0 3804279 19.602 % 14/10/2015
Edward C. Johnson 3d United States of America 0 0 3804279 0 3804279 19.602 % 14/10/2015
FMR LLC Delaware 3804279 0 3804279 0 3804279 19.602 % 14/10/2015
FMR LLC Delaware 3804279 0 3804279 0 3804279 19.602 % 14/10/2015
Edward C. Johnson 3d United States of America 0 0 3804279 0 3804279 19.602 % 14/10/2015
RA Capital Management, LLC Massachusetts 0 2237130 0 2237130 2237130 11.5 % 13/10/2015
RA Capital Healthcare Fund, L.P. Delaware 0 1871841 0 1871841 1871841 9.6 % 13/10/2015
RA Capital Healthcare Fund, L.P. Delaware 0 1871841 0 1871841 1871841 9.6 % 13/10/2015
RA Capital Management, LLC Massachusetts 0 2237130 0 2237130 2237130 11.5 % 13/10/2015
Peter Kolchinsky United States 0 2237130 0 2237130 2237130 11.5 % 13/10/2015
Peter Kolchinsky United States 0 2237130 0 2237130 2237130 11.5 % 13/10/2015

Senat trading

Bureau Date de la transaction Date de réception Type Amount Commentaire

Senat Divulgation

Représentant Date de la transaction Date de divulgation Type Amount District