| Company, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| Situations Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| James E. Flynn |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| John Schutte |
United States |
10695186 |
0 |
10695186 |
0 |
10695186 |
47.5 % |
03/08/2017 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
1025641 |
0 |
0 |
1025641 |
8.67 % |
14/02/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
1025641 |
0 |
0 |
1025641 |
8.67 % |
14/02/2017 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
1025641 |
0 |
0 |
1025641 |
8.67 % |
14/02/2017 |
| James E. Flynn |
United States |
0 |
1025641 |
0 |
0 |
1025641 |
8.67 % |
14/02/2017 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
1025641 |
0 |
0 |
1025641 |
8.69 % |
16/02/2016 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
1025641 |
0 |
0 |
1025641 |
8.69 % |
16/02/2016 |
| James E. Flynn |
Delaware |
0 |
1025641 |
0 |
0 |
1025641 |
8.69 % |
16/02/2016 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
1025641 |
0 |
0 |
1025641 |
8.69 % |
16/02/2016 |
| Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
4661795 |
0 |
4661795 |
4661795 |
7.9 % |
09/07/2015 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
5128205 |
0 |
0 |
5128205 |
8.69 % |
08/07/2015 |
| James E. Flynn |
Delaware |
0 |
5128205 |
0 |
0 |
5128205 |
8.69 % |
08/07/2015 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
5128205 |
0 |
0 |
5128205 |
8.69 % |
08/07/2015 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
5128205 |
0 |
0 |
5128205 |
8.69 % |
08/07/2015 |
| Care Capital Offshore Investments II, LP |
Cayman Islands |
0 |
213496 |
0 |
10 |
213496 |
0.4 % |
09/03/2015 |
| Care Capital Investments II, LP |
Delaware |
0 |
3112126 |
0 |
10 |
3112126 |
6.4 % |
09/03/2015 |
| Care Capital II, LLC |
Delaware |
0 |
3325622 |
0 |
10 |
3325622 |
6.8 % |
09/03/2015 |
| Care Capital Offshore Investments II, LP |
Cayman Islands |
0 |
245189 |
0 |
10 |
245189 |
0.5 % |
30/01/2015 |
| Care Capital II, LLC |
Delaware |
0 |
3819286 |
0 |
10 |
3819286 |
7.8 % |
30/01/2015 |
| Care Capital Investments II, LP |
Delaware |
0 |
3574097 |
0 |
10 |
3574097 |
7.4 % |
30/01/2015 |
| Care Capital II, LLC |
Delaware |
0 |
5798793 |
0 |
10 |
5798793 |
12.3 % |
24/06/2013 |
| Care Capital Offshore Investments II, LP |
Cayman Islands |
0 |
372274 |
0 |
10 |
372274 |
0.8 % |
24/06/2013 |
| Care Capital Investments II, LP |
Delaware |
0 |
5426519 |
0 |
10 |
5426519 |
11.5 % |
24/06/2013 |
| Care Capital Investments II, LP |
Delaware |
0 |
6185183 |
0 |
10 |
6185183 |
13.1 % |
23/05/2013 |
| Care Capital Offshore Investments II, LP |
Cayman Islands |
0 |
424311 |
0 |
10 |
424311 |
0.9 % |
23/05/2013 |
| Care Capital II, LLC |
Delaware |
0 |
6609494 |
0 |
10 |
6609494 |
14 % |
23/05/2013 |
| Care Capital Investments II, LP |
Delaware |
0 |
7818149 |
0 |
10 |
7818149 |
16.6 % |
08/05/2013 |
| Care Capital Offshore Investments II, LP |
Cayman Islands |
0 |
536345 |
0 |
10 |
536345 |
1.2 % |
08/05/2013 |
| Care Capital II, LLC |
Delaware |
0 |
8354494 |
0 |
10 |
8354494 |
17.7 % |
08/05/2013 |
| Care Capital II, LLC |
Delaware |
0 |
9222746 |
0 |
10 |
9222746 |
19.6 % |
24/04/2013 |
| Care Capital Investments II, LP |
Delaware |
0 |
8630655 |
0 |
10 |
8630655 |
18.3 % |
24/04/2013 |
| Care Capital Offshore Investments II, LP |
Cayman Islands |
0 |
592091 |
0 |
10 |
592091 |
1.3 % |
24/04/2013 |
| Care Capital Investments II, LP |
Delaware |
0 |
10052745 |
0 |
10 |
10052745 |
21.6 % |
27/12/2012 |
| Care Capital II, LLC |
Delaware |
0 |
10742398 |
0 |
10 |
10742398 |
23 % |
27/12/2012 |
| Care Capital Offshore Investments II, LP |
Cayman Islands |
0 |
689653 |
0 |
10 |
689653 |
1.5 % |
27/12/2012 |
| ================================================================ |
================================================================ |
875872 |
0 |
875872 |
0 |
875872 |
6.08 % |
18/12/1998 |
| ================================================================ |
================================================================ |
1908364 |
0 |
1908364 |
0 |
1908364 |
12.44 % |
24/03/1998 |
| ================================================================ |
================================================================ |
1908364 |
0 |
1908364 |
0 |
1908364 |
12.44 % |
23/03/1998 |
| PETER ZUELLIG |
SCHEDULE 13D |
0 |
639227 |
0 |
639227 |
639227 |
5.4 % |
12/02/1997 |