Samir R. Patel |
United States |
2492386 |
0 |
2492386 |
0 |
2492386 |
7.2 % |
16/02/2021 |
Yasumitsu Shigeta |
Japan |
1230063 |
0 |
1230063 |
0 |
1230063 |
3.67 % |
11/08/2020 |
WML Ventures Corp. |
Illinois |
0 |
673580900 |
0 |
673580900 |
673580900 |
19.89 % |
02/07/2020 |
William F. Blank, III |
United States |
0 |
673580900 |
0 |
673580900 |
673580900 |
19.89 % |
02/07/2020 |
Steven G. Martin |
United States |
0 |
673580900 |
0 |
673580900 |
673580900 |
19.89 % |
02/07/2020 |
SGM Holdings Corp. |
Illinois |
0 |
673580900 |
0 |
673580900 |
673580900 |
19.89 % |
02/07/2020 |
Red Cedar Capital Corp. |
Illinois |
0 |
673580900 |
0 |
673580900 |
673580900 |
19.89 % |
02/07/2020 |
Chrisko Investors, Inc. |
Illinois |
0 |
673580900 |
0 |
673580900 |
673580900 |
19.89 % |
02/07/2020 |
Aspire Capital Fund, LLC |
Illinois |
0 |
673580900 |
0 |
673580900 |
673580900 |
19.89 % |
02/07/2020 |
Aspire Capital Partners, LLC |
Illinois |
0 |
673580900 |
0 |
673580900 |
673580900 |
19.89 % |
02/07/2020 |
Erik J. Brown |
United States |
0 |
673580900 |
0 |
673580900 |
673580900 |
19.89 % |
02/07/2020 |
Christos Komissopoulos |
United States |
0 |
673580900 |
0 |
673580900 |
673580900 |
19.89 % |
02/07/2020 |
Samir R. Patel |
United States |
1475523 |
0 |
1475523 |
0 |
1475523 |
7.1 % |
04/10/2019 |
Yasumitsu Shigeta |
Japan |
1500096 |
0 |
1500096 |
0 |
1500096 |
7.94 % |
19/08/2019 |
S James E. Flynn |
United States |
0 |
249785 |
0 |
249785 |
249785 |
2.12 % |
14/02/2018 |
S Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
249785 |
0 |
249785 |
249785 |
2.12 % |
14/02/2018 |
S Deerfield Management Company, L.P. |
Delaware |
0 |
249785 |
0 |
249785 |
249785 |
2.12 % |
14/02/2018 |
S Deerfield Mgmt III, L.P. |
Delaware |
0 |
249785 |
0 |
249785 |
249785 |
2.12 % |
14/02/2018 |
S Deerfield Mgmt, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
S Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
S Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
575350 |
0 |
575350 |
575350 |
4.89 % |
14/02/2017 |
S James E. Flynn |
United States |
0 |
1150700 |
0 |
1150700 |
1150700 |
9.77 % |
14/02/2017 |
S Deerfield Management Company, L.P. |
Delaware |
0 |
1150700 |
0 |
1150700 |
1150700 |
9.77 % |
14/02/2017 |
S Deerfield Mgmt III, L.P. |
Delaware |
0 |
575350 |
0 |
575350 |
575350 |
4.89 % |
14/02/2017 |
S Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
575350 |
0 |
575350 |
575350 |
4.89 % |
14/02/2017 |
S Deerfield Mgmt, L.P. |
Delaware |
0 |
575350 |
0 |
575350 |
575350 |
4.89 % |
14/02/2017 |
MVA Investors, LLC |
Delaware |
|
10556 |
0 |
10556 |
10566 |
0.1 % |
16/02/2016 |
Joe Lewis |
United Kingdom |
0 |
139899 |
0 |
139899 |
139899 |
1.2 % |
16/02/2016 |
Boxer Capital, LLC |
Delaware |
0 |
139899 |
0 |
139899 |
139899 |
1.2 % |
16/02/2016 |
Boxer Asset Management, Inc. |
Bahamas |
0 |
139899 |
0 |
139899 |
139899 |
1.2 % |
16/02/2016 |
Joe Lewis |
United Kingdom |
0 |
139899 |
0 |
139899 |
139899 |
1.2 % |
16/02/2016 |
MVA Investors, LLC |
Delaware |
|
10556 |
0 |
10556 |
10566 |
0.1 % |
16/02/2016 |
Boxer Capital, LLC |
Delaware |
0 |
139899 |
0 |
139899 |
139899 |
1.2 % |
16/02/2016 |
Boxer Asset Management, Inc. |
Bahamas |
0 |
139899 |
0 |
139899 |
139899 |
1.2 % |
16/02/2016 |
Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Cormorant Asset Management, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Bihua Chen |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Bihua Chen |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Cormorant Asset Management, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
James E. Flynn |
United States |
0 |
1150700 |
0 |
1150700 |
1150700 |
9.77 % |
16/02/2016 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
575350 |
0 |
575350 |
575350 |
4.89 % |
16/02/2016 |
Deerfield Management Company, L.P. |
Delaware |
0 |
1150700 |
0 |
1150700 |
1150700 |
9.77 % |
16/02/2016 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
575350 |
0 |
575350 |
575350 |
4.89 % |
16/02/2016 |
Deerfield Mgmt III, L.P. |
Delaware |
0 |
575350 |
0 |
575350 |
575350 |
4.89 % |
16/02/2016 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
575350 |
0 |
575350 |
575350 |
4.89 % |
16/02/2016 |
Deerfield Management Company, L.P. |
Delaware |
0 |
1150700 |
0 |
1150700 |
1150700 |
9.77 % |
16/02/2016 |
Deerfield Mgmt III, L.P. |
Delaware |
0 |
575350 |
0 |
575350 |
575350 |
4.89 % |
16/02/2016 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
575350 |
0 |
575350 |
575350 |
4.89 % |
16/02/2016 |
Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
575350 |
0 |
575350 |
575350 |
4.89 % |
16/02/2016 |
James E. Flynn |
United States |
0 |
1150700 |
0 |
1150700 |
1150700 |
9.77 % |
16/02/2016 |
Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
575350 |
0 |
575350 |
575350 |
4.89 % |
16/02/2016 |
Charles B. Johnson |
USA |
4 |
4 |
4 |
4 |
0 |
0 % |
09/02/2016 |
Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
0 |
0 % |
09/02/2016 |
Rupert H. Johnson, Jr. |
USA |
4 |
4 |
4 |
4 |
0 |
0 % |
09/02/2016 |
Sabby Management, LLC |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
08/01/2016 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
08/01/2016 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
08/01/2016 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
08/01/2016 |
Sabby Management, LLC |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
08/01/2016 |
Hal Mintz |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
08/01/2016 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
08/01/2016 |
Hal Mintz |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
08/01/2016 |
Deerfield Management Company, L.P. |
Delaware |
0 |
115070000 |
0 |
115070000 |
115070000 |
9.77 % |
21/09/2015 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
57535000 |
0 |
57535000 |
57535000 |
4.89 % |
21/09/2015 |
Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
57535000 |
0 |
57535000 |
57535000 |
4.89 % |
21/09/2015 |
James E. Flynn |
United States |
0 |
115070000 |
0 |
115070000 |
115070000 |
9.77 % |
21/09/2015 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
57535000 |
0 |
57535000 |
57535000 |
4.89 % |
21/09/2015 |
Deerfield Management Company, L.P. |
Delaware |
0 |
115070000 |
0 |
115070000 |
115070000 |
9.77 % |
21/09/2015 |
Deerfield Mgmt III, L.P. |
Delaware |
0 |
57535000 |
0 |
57535000 |
57535000 |
4.89 % |
21/09/2015 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
57535000 |
0 |
57535000 |
57535000 |
4.89 % |
21/09/2015 |
Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
57535000 |
0 |
57535000 |
57535000 |
4.89 % |
21/09/2015 |
James E. Flynn |
United States |
0 |
115070000 |
0 |
115070000 |
115070000 |
9.77 % |
21/09/2015 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
57535000 |
0 |
57535000 |
57535000 |
4.89 % |
21/09/2015 |
Deerfield Mgmt III, L.P. |
Delaware |
0 |
57535000 |
0 |
57535000 |
57535000 |
4.89 % |
21/09/2015 |
Boxer Asset Management, Inc. |
Bahamas |
0 |
500000 |
0 |
500000 |
500000 |
9 % |
28/08/2015 |
Joe Lewis |
United Kingdom |
0 |
500000 |
0 |
500000 |
500000 |
9 % |
28/08/2015 |
Boxer Capital, LLC |
Delaware |
0 |
500000 |
0 |
500000 |
500000 |
9 % |
28/08/2015 |
Baker Bros. Advisors |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/03/2015 |
Baker Bros. Advisors LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/03/2015 |
Julian C. Baker |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
10/03/2015 |
Felix J. Baker |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
10/03/2015 |
Baker Bros. Advisors LP |
Delaware |
6738870 |
0 |
6738870 |
0 |
6738870 |
12.1 % |
17/02/2015 |
Baker Bros. Advisors |
Delaware |
6738870 |
0 |
6738870 |
0 |
6738870 |
12.1 % |
17/02/2015 |
Broadfin Capital, LLC |
Delaware |
0 |
4708774 |
0 |
4708774 |
4708774 |
8.5 % |
17/02/2015 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
4708774 |
0 |
4708774 |
4708774 |
8.5 % |
17/02/2015 |
Kevin Kotler |
United States of America |
0 |
4708774 |
0 |
4708774 |
4708774 |
8.5 % |
17/02/2015 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
5385000 |
0 |
5385000 |
5385000 |
9.68 % |
09/01/2015 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
09/01/2015 |
Hal Mintz |
USA |
0 |
5385000 |
0 |
5385000 |
5385000 |
9.68 % |
09/01/2015 |
Sabby Management, LLC |
Delaware, USA |
0 |
5385000 |
0 |
5385000 |
5385000 |
9.68 % |
09/01/2015 |
Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
5.39 % |
24/11/2014 |
Cormorant Asset Management, LLC |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
5.39 % |
24/11/2014 |
Bihua Chen |
United States |
0 |
3000000 |
0 |
3000000 |
3000000 |
5.39 % |
24/11/2014 |
Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
3000000 |
0 |
3000000 |
3000000 |
5.39 % |
24/11/2014 |
Hal Mintz |
USA |
0 |
3508772 |
0 |
3508772 |
3508772 |
8.72 % |
28/01/2014 |
Sabby Management, LLC |
Delaware USA |
0 |
3508772 |
0 |
3508772 |
3508772 |
8.72 % |
28/01/2014 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
28/01/2014 |
Sabby Healthcare Volatility Master Fund, Ltd. |
Cayman Islands |
0 |
3508772 |
0 |
3508772 |
3508772 |
8.72 % |
28/01/2014 |
Baker Bros. Advisors LP |
Delaware |
5263162 |
0 |
5263162 |
0 |
5263162 |
13.1 % |
06/01/2014 |
Baker Bros. Advisors |
Delaware |
5263162 |
0 |
5263162 |
0 |
5263162 |
13.1 % |
06/01/2014 |
Felix J. Baker |
United States |
5263162 |
0 |
5263162 |
0 |
5263162 |
13.1 % |
06/01/2014 |
Julian C. Baker |
United States |
5263162 |
0 |
5263162 |
0 |
5263162 |
13.1 % |
06/01/2014 |
Franklin Advisers, Inc. |
California |
7017544 |
0 |
7017544 |
0 |
7017544 |
17.4 % |
10/12/2013 |
Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
7017544 |
17.4 % |
10/12/2013 |
Charles B. Johnson |
USA |
4 |
4 |
4 |
4 |
7017544 |
17.4 % |
10/12/2013 |
Rupert H. Johnson, Jr. |
USA |
4 |
4 |
4 |
4 |
7017544 |
17.4 % |
10/12/2013 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
3508772 |
0 |
3508772 |
3508772 |
8.9 % |
04/10/2013 |
Broadfin Capital, LLC |
Delaware |
0 |
3508772 |
0 |
3508772 |
3508772 |
8.9 % |
04/10/2013 |
Kevin Kotler |
United States of America |
0 |
3508772 |
0 |
3508772 |
3508772 |
8.9 % |
04/10/2013 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
877193 |
0 |
877193 |
877193 |
2.18 % |
24/09/2013 |
Sabby Management, LLC |
Delaware USA |
0 |
3508772 |
0 |
3508772 |
3508772 |
8.72 % |
24/09/2013 |
Hal Mintz |
USA |
0 |
3508772 |
0 |
3508772 |
3508772 |
8.72 % |
24/09/2013 |
Sabby Healthcare Volatility Master Fund, Ltd. |
Cayman Islands |
0 |
2631579 |
0 |
2631579 |
2631579 |
6.54 % |
24/09/2013 |