ALPN

Alpine Immune Sciences, Inc. ALPN

Trading inactive

Individual Beneficiary

Name of reporting person Citizenship or organization Sole voting power Shared voting power Sole dispositive power Shared dispositive power Amount beneficially owned Percent of class Accepted date
(1) BlackRock, Inc. Delaware 3008066 0 3058498 0 3058498 5.3 % 02/02/2024
Cormorant Asset Management, LP Delaware 0 2850000 0 2850000 2850000 5.79 % 23/10/2023
Cormorant Global Healthcare GP, LLC Delaware 0 2850000 0 2850000 2850000 5.79 % 23/10/2023
Cormorant Asset Management, LP Delaware 0 2850000 0 2850000 2850000 5.79 % 23/10/2023
Bihua Chen Delaware 0 2850000 0 2850000 2850000 5.79 % 23/10/2023
Cormorant Global Healthcare Master Fund, LP Delaware 0 2850000 0 2850000 2850000 5.79 % 23/10/2023
Cormorant Global Healthcare Master Fund, LP Cayman Islands 0 2850000 0 2850000 2850000 5.79 % 23/10/2023
Cormorant Global Healthcare GP, LLC Delaware 0 2850000 0 2850000 2850000 5.79 % 23/10/2023
Bihua Chen United States 0 2850000 0 2850000 2850000 5.79 % 23/10/2023
Paradigm BioCapital Advisors LP Cayman Islands 1554920 0 1554920 0 2214722 5.03 % 03/10/2022
Rajeev Shah Delaware 0 4356632 0 0 4356632 9.91 % 03/10/2022
RA Capital Management, L.P. Delaware 0 4356632 0 0 4356632 9.91 % 03/10/2022
RA Capital Healthcare Fund, L.P. Delaware 0 4356632 0 0 4356632 9.91 % 03/10/2022
RA Capital Management, L.P. Delaware 0 4356632 0 0 4356632 9.91 % 03/10/2022
Peter Kolchinsky Delaware 0 4356632 0 0 4356632 9.91 % 03/10/2022
Rajeev Shah Delaware 0 4356632 0 0 4356632 9.91 % 03/10/2022
RA Capital Healthcare Fund, L.P. Delaware 0 4356632 0 0 4356632 9.91 % 03/10/2022
Peter Kolchinsky Delaware 0 4356632 0 0 4356632 9.91 % 03/10/2022
Dr. Jeffrey R. Jay, M.D. Delaware 0 3448521 0 0 3448521 7.85 % 30/09/2022
Dr. Jeffrey R. Jay, M.D. USA 0 3448521 0 0 3448521 7.85 % 30/09/2022
Mr. Ortav Yehudai USA 0 3448521 0 0 3448521 7.85 % 30/09/2022
Mr. Ortav Yehudai Delaware 0 3448521 0 0 3448521 7.85 % 30/09/2022
Great Point Partners, LLC Delaware 0 3448521 0 0 3448521 7.85 % 30/09/2022
Great Point Partners, LLC Delaware 0 3448521 0 0 3448521 7.85 % 30/09/2022
Jay Venkatesan 388042 2675421 388042 2675421 3063463 6.9 % 27/09/2022
Mitchell H. Gold 1230169 2675421 1230169 2675421 3905590 8.6 % 27/09/2022
Alpine Immunosciences, L.P. 0 2675421 0 2675421 2675421 6.1 % 27/09/2022
Alpine BioVentures, GP, LLC 0 2675421 0 2675421 2675421 6.1 % 27/09/2022
Weston Nichols Delaware 0 1537345 0 0 1537345 5.1 % 22/04/2022
Lynx1 Capital Management LP Delaware 0 1537345 0 0 1537345 5.1 % 22/04/2022
Lynx1 Capital Management LP Delaware 0 1537345 0 0 1537345 5.1 % 22/04/2022
Weston Nichols Delaware 0 1537345 0 0 1537345 5.1 % 22/04/2022
James Brush 0 1501642 0 1501642 1501642 5.1 % 15/02/2022
FHMLSP, L.P. 0 1501642 0 1501642 1501642 5.1 % 15/02/2022
Frazier Life Sciences VIII, L.P. 0 1629366 0 1629366 1629366 5.5 % 15/02/2022
FHM Life Sciences VIII, L.P. 0 1629366 0 1629366 1629366 5.5 % 15/02/2022
FHM Life Sciences VIII, L.L.C. 0 1629366 0 1629366 1629366 5.5 % 15/02/2022
Frazier Life Sciences Public Fund L.P. 0 1501642 0 1501642 1501642 5.1 % 15/02/2022
FHMLSP, L.L.C. 0 1501642 0 1501642 1501642 5.1 % 15/02/2022
James N. Topper 33100 3131008 33100 3131008 3164108 10.8 % 15/02/2022
Patrick J. Heron 0 3131008 0 3131008 3131008 10.7 % 15/02/2022
Albert Cha 0 1501642 0 1501642 1501642 5.1 % 15/02/2022
Omega Fund VI GP Manager, Ltd. 0 2415050 0 2415050 2415050 8.2 % 14/02/2022
Omega Fund VI GP, L.P. 0 2415050 0 2415050 2415050 8.2 % 14/02/2022
Omega Fund VI, L.P. 0 2415050 0 2415050 2415050 8.2 % 14/02/2022
Otello Stampacchia 0 2415050 0 2415050 2415050 8.2 % 14/02/2022
Anne-Mari Paster 0 2415050 0 2415050 2415050 8.2 % 14/02/2022
Claudio Nessi 0 2415050 0 2415050 2415050 8.2 % 14/02/2022
Decheng Capital Management III (Cayman), LLC 4708288 0 4708288 0 4708288 16.11 % 14/02/2022
Decheng Capital Management III (Cayman), LLC 4708288 0 4708288 0 4708288 16.11 % 14/02/2022
Avidity Partners Management (GP) LLC 0 2205687 0 2205687 2205687 7.3 % 11/02/2022
Avidity Master Fund LP 0 1773592 0 1773592 1773592 5.9 % 11/02/2022
David Witzke 0 2205687 0 2205687 2205687 7.3 % 11/02/2022
Michael Gregory 0 2205687 0 2205687 2205687 7.3 % 11/02/2022
Avidity Partners Management LP 0 2205687 0 2205687 2205687 7.3 % 11/02/2022
Avidity Capital Partners Fund (GP) LP 0 2205687 0 2205687 2205687 7.3 % 11/02/2022
Avidity Capital Partners (GP) LLC 0 2205687 0 2205687 2205687 7.3 % 11/02/2022
Decheng Capital Management III (Cayman), LLC 0 5942924 0 5942924 5942924 19.5 % 21/09/2021
L.P. 0 5942924 0 5942924 5942924 19.5 % 21/09/2021
Xiangmin Cui 21037 5942924 21037 5942924 5963961 19.6 % 21/09/2021
David Witzke United States America 0 1470390 0 1470390 1470390 6.2 % 16/02/2021
Avidity Capital Partners Fund (GP) LP United States America 0 1470390 0 1470390 1470390 6.2 % 16/02/2021
Michael Gregory United States America 0 1470390 0 1470390 1470390 6.2 % 16/02/2021
Avidity Partners Management LP United States America 0 1470390 0 1470390 1470390 6.2 % 16/02/2021
Avidity Capital Partners (GP) LLC United States America 0 1470390 0 1470390 1470390 6.2 % 16/02/2021
Avidity Master Fund LP United States America 0 1312916 0 1312916 1312916 5.5 % 16/02/2021
Avidity Partners Management (GP) LLC United States America 0 1470390 0 1470390 1470390 6.2 % 16/02/2021
OrbiMed Advisors LLC Delaware 0 3216206 0 10 3216206 13.4 % 30/12/2020
OrbiMed Capital GP VI LLC Delaware 0 3216206 0 10 3216206 13.4 % 30/12/2020
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Delaware 0 1337413 0 1337413 1337413 5.62 % 23/12/2020
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Delaware 0 1337413 0 1337413 1337413 5.64 % 23/12/2020
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Delaware 0 1337413 0 1337413 1337413 5.66 % 23/12/2020
David Witzke Delaware 0 1337413 0 1337413 1337413 5.6 % 23/12/2020
Avidity Partners Management (GP) LLC Delaware 0 1337413 0 1337413 1337413 5.6 % 23/12/2020
Avidity Partners Management LP Delaware 0 1337413 0 1337413 1337413 5.6 % 23/12/2020
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Delaware 0 1337413 0 1337413 1211485 5.15 % 23/12/2020
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Delaware 0 1337413 0 1337413 1337413 5.63 % 23/12/2020
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Delaware 0 1337413 0 1337413 1337413 5.67 % 23/12/2020
Michael Gregory Delaware 0 1337413 0 1337413 1337413 5.6 % 23/12/2020
Avidity Master Fund LP Delaware 0 1211485 0 1211485 1211485 5.1 % 23/12/2020
Avidity Capital Partners Fund (GP) LP Delaware 0 1337413 0 1337413 1337413 5.6 % 23/12/2020
Avidity Capital Partners (GP) LLC Delaware 0 1337413 0 1337413 1337413 5.6 % 23/12/2020
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Delaware 0 1337413 0 1337413 1337413 5.61 % 23/12/2020
Mitchell H. Gold 1137187 3075421 1137187 3075421 4212608 17.1 % 22/12/2020
Alpine BioVentures, GP, LLC 0 3075421 0 3075421 3075421 12.9 % 22/12/2020
Alpine Immunosciences, L.P. 0 3075421 0 3075421 3075421 12.9 % 22/12/2020
Jay Venkatesan 327396 3112687 327396 3112687 3440083 14.3 % 22/12/2020
of 11 Pages Cayman Islands 0 1670370 0 1670370 1670370 6.9 % 06/08/2020
of 11 Pages Cayman Islands 0 1670370 0 1670370 1670370 6.9 % 06/08/2020
of 11 Pages Cayman Islands 0 1670370 0 1670370 1670370 6.9 % 06/08/2020
of 11 Pages Cayman Islands 0 1670370 0 1670370 1670370 6.9 % 06/08/2020
of 11 Pages Cayman Islands 0 1670370 0 1670370 1670370 6.9 % 06/08/2020
of 11 Pages Cayman Islands 0 1670370 0 1670370 1670370 6.9 % 06/08/2020
of 11 Pages Cayman Islands 0 1670370 0 1670370 1670370 6.9 % 06/08/2020
of 11 Pages Cayman Islands 0 1670370 0 1670370 1670370 6.9 % 06/08/2020
of 11 Pages Cayman Islands 0 1670370 0 1670370 1670370 6.9 % 06/08/2020
of 11 Pages Cayman Islands 0 1670370 0 1670370 1670370 6.9 % 06/08/2020
of 11 Pages Cayman Islands 0 1670370 0 1670370 1670370 6.9 % 06/08/2020
of 11 Pages Cayman Islands 0 1670370 0 1670370 1670370 6.9 % 06/08/2020
James Topper 20400 2716701 20400 11 2737101 11.5 % 30/07/2020
FHM Life Sciences VIII, L.L.C. 0 2716701 0 11 2716701 11.4 % 30/07/2020
FHM Life Sciences VIII, L.P. 0 2716701 0 11 2716701 11.4 % 30/07/2020
Frazier Life Sciences VIII, L.P. 0 2716701 0 11 2716701 11.4 % 30/07/2020
Patrick J. Heron 0 2716701 0 11 2716701 11.4 % 30/07/2020
OrbiMed Capital GP VI LLC Delaware 0 3816206 0 10 3816206 16 % 30/07/2020
OrbiMed Advisors LLC Delaware 0 3816206 0 10 3816206 16 % 30/07/2020
BVF Partners OS Ltd. 0 0 0 83002 83002 1 % 14/02/2020
BVF GP HOLDINGS LLC 0 0 0 1032499 1032499 5.6 % 14/02/2020
BVF Partners L.P. 0 0 0 1137764 1137764 6.1 % 14/02/2020
BVF Inc. 0 0 0 1137764 1137764 6.1 % 14/02/2020
Biotechnology Value Fund, L.P. 0 0 0 571646 571646 3.1 % 14/02/2020
BVF I GP LLC 0 0 0 571646 571646 3.1 % 14/02/2020
Biotechnology Value Fund II, L.P. 0 0 0 460853 460853 2.5 % 14/02/2020
BVF II GP LLC 0 0 0 460853 460853 2.5 % 14/02/2020
Biotechnology Value Trading Fund OS LP 0 0 0 83002 83002 1 % 14/02/2020
Mark N. Lampert 0 0 0 1137764 1137764 6.1 % 14/02/2020
Biotechnology Value Fund, L.P. Delaware 0 0 0 584078 584078 3.1 % 28/01/2019
Biotechnology Value Trading Fund OS LP Delaware 0 0 0 84524 84524 1 % 28/01/2019
BVF Partners OS Ltd. Delaware 0 0 0 84524 84524 1 % 28/01/2019
BVF Partners L.P. Delaware 0 0 0 1201718 1201718 6.5 % 28/01/2019
BVF Inc. Delaware 0 0 0 1201718 1201718 6.5 % 28/01/2019
Mark N. Lampert Delaware 0 0 0 1201718 1201718 6.5 % 28/01/2019
Biotechnology Value Fund II, L.P. Delaware 0 0 0 460853 460853 2.5 % 28/01/2019
Mark N. Lampert Delaware 0 0 0 1201718 1201718 6.5 % 28/01/2019
BVF Inc. Delaware 0 0 0 1201718 1201718 6.5 % 28/01/2019
BVF Partners L.P. Delaware 0 0 0 1201718 1201718 6.5 % 28/01/2019
BVF Partners OS Ltd. Delaware 0 0 0 84524 84524 1 % 28/01/2019
Biotechnology Value Trading Fund OS LP Delaware 0 0 0 84524 84524 1 % 28/01/2019
Biotechnology Value Fund II, L.P. Delaware 0 0 0 460853 460853 2.5 % 28/01/2019
Biotechnology Value Fund, L.P. Delaware 0 0 0 584078 584078 3.1 % 28/01/2019
Decheng Capital Management III (Cayman), LLC Cayman Islands 0 3845952 0 3845952 3845952 19.9 % 24/01/2019
Xiangmin Cui United States 637 3845952 637 3845952 3846589 19.9 % 24/01/2019
Decheng Capital China Life Sciences USD Fund III, L.P. Cayman Islands 0 3845952 0 3845952 3845952 19.9 % 24/01/2019
OrbiMed Advisors LLC Delaware 0 3816206 0 10 3816206 20.4 % 23/01/2019
OrbiMed Capital GP VI LLC Delaware 0 3816206 0 10 3816206 20.4 % 23/01/2019
OrbiMed Advisors LLC Delaware 0 3298516 0 10 3298516 23.76 % 26/01/2018
OrbiMed Capital GP VI LLC Delaware 0 3298516 0 10 3298516 23.76 % 26/01/2018
Deerfield Private Design Fund II, L.P. Delaware 0 181560 0 10 181560 1.31 % 22/08/2017
Deerfield Private Design International II, L.P. British Virgin Islands 0 208053 0 10 208053 1.5 % 22/08/2017
Deerfield Private Design Fund, L.P. Delaware 0 100515 0 10 100515 0.72 % 22/08/2017
L.P. Delaware 0 933100 0 10 933100 6.72 % 22/08/2017
Deerfield Management Company, L.P. Delaware 0 936175 0 10 936175 6.74 % 22/08/2017
Situations Fund, L.P. Delaware 0 281184 0 10 281184 2.03 % 22/08/2017
James E. Flynn United States of America 0 936175 0 10 936175 6.74 % 22/08/2017
Deerfield Private Design International, L.P. British Virgin Islands 0 161788 0 10 161788 1.17 % 22/08/2017
Samuel D. Isaly United States 0 3298516 0 10 3298516 23.76 % 03/08/2017
OrbiMed Capital GP VI LLC Delaware 0 3298516 0 10 3298516 23.76 % 03/08/2017
OrbiMed Advisors LLC Delaware 0 3298516 0 10 3298516 23.76 % 03/08/2017
Deerfield Management Company, L.P. Delaware 0 936175 0 10 936175 6.74 % 28/07/2017
Deerfield Private Design International II, L.P. British Virgin Islands 0 208053 0 10 208053 1.5 % 28/07/2017
Deerfield Private Design Fund II, L.P. Delaware 0 181560 0 10 181560 1.31 % 28/07/2017
Deerfield Private Design International, L.P. British Virgin Islands 0 161788 0 10 161788 1.17 % 28/07/2017
Deerfield Private Design Fund, L.P. Delaware 0 100515 0 10 100515 0.72 % 28/07/2017
Situations Fund, L.P. Delaware 0 281184 0 10 281184 2.03 % 28/07/2017
James E. Flynn United States of America 0 936175 0 10 936175 6.74 % 28/07/2017
L.P. Delaware 0 933100 0 10 933100 6.72 % 28/07/2017
BVF Partners L.P. Delaware 0 0 0 661200 661200 4.8 % 27/07/2017
Biotechnology Value Fund, L.P. Delaware 0 0 0 277314 277314 2 % 27/07/2017
Biotechnology Value Fund II, L.P. Delaware 0 0 0 179272 179272 1.3 % 27/07/2017
Biotechnology Value Trading Fund OS LP Delaware 0 0 0 50452 50452 1 % 27/07/2017
BVF Partners OS Ltd. Delaware 0 0 0 50452 50452 1 % 27/07/2017
BVF Inc. Delaware 0 0 0 661200 661200 4.8 % 27/07/2017
Mark N. Lampert Delaware 0 0 0 661200 661200 4.8 % 27/07/2017
Wellington Management Group LLP Massachusetts 0 0 0 0 0 0 % 10/02/2017
Wellington Management Group LLP Massachusetts 0 1180531 0 0 1272256 8.19 % 09/02/2017
Wellington Group Holdings LLP Delaware 0 1180531 0 0 1272256 8.19 % 09/02/2017
Wellington Investment Advisors Holdings LLP Delaware 0 1180531 0 0 1272256 8.19 % 09/02/2017
Wellington Management Company LLP Delaware 0 1155991 0 0 1213291 7.81 % 09/02/2017
Mark N. Lampert Delaware 0 1546743 0 0 1546743 10 % 22/03/2016
BVF Partners L.P. Delaware 0 1546743 0 0 1546743 10 % 22/03/2016
BVF Partners OS Ltd. Delaware 0 134133 0 0 134133 1 % 22/03/2016
Biotechnology Value Trading Fund OS LP Delaware 0 134133 0 0 134133 1 % 22/03/2016
Biotechnology Value Fund, L.P. Delaware 0 671798 0 0 671798 4.3 % 22/03/2016
Biotechnology Value Fund II, L.P. Delaware 0 417486 0 0 417486 2.7 % 22/03/2016
BVF Inc. Delaware 0 1546743 0 0 1546743 10 % 22/03/2016
Wellington Management Group LLP Massachusetts 0 1701724 0 0 1811453 11.72 % 11/02/2016
Wellington Investment Advisors Holdings LLP Delaware 0 1701724 0 0 1811453 11.72 % 11/02/2016
Wellington Management Company LLP Delaware 0 1691124 0 0 1771174 11.46 % 11/02/2016
Wellington Group Holdings LLP Delaware 0 1701724 0 0 1811453 11.72 % 11/02/2016
Estate of Arnold H. Snider, III United States 1557228 0 1557228 0 1557228 10.1 % 04/02/2016
Biotechnology Value Trading Fund OS LP Delaware 0 105335 0 0 105335 1 % 21/12/2015
Mark N. Lampert Delaware 0 1195013 0 0 1195013 7.7 % 21/12/2015
BVF Partners L.P. Delaware 0 1195013 0 0 1195013 7.7 % 21/12/2015
BVF Partners L.P. Delaware 0 1195013 0 0 1195013 7.7 % 21/12/2015
Mark N. Lampert Delaware 0 1195013 0 0 1195013 7.7 % 21/12/2015
BVF Partners OS Ltd. Delaware 0 105335 0 0 105335 1 % 21/12/2015
Biotechnology Value Fund, L.P. Delaware 0 512140 0 0 512140 3.3 % 21/12/2015
Biotechnology Value Fund, L.P. Delaware 0 512140 0 0 512140 3.3 % 21/12/2015
BVF Partners OS Ltd. Delaware 0 105335 0 0 105335 1 % 21/12/2015
BVF Inc. Delaware 0 1195013 0 0 1195013 7.7 % 21/12/2015
Biotechnology Value Fund II, L.P. Delaware 0 298247 0 0 298247 1.9 % 21/12/2015
Biotechnology Value Trading Fund OS LP Delaware 0 105335 0 0 105335 1 % 21/12/2015
Biotechnology Value Fund II, L.P. Delaware 0 298247 0 0 298247 1.9 % 21/12/2015
BVF Inc. Delaware 0 1195013 0 0 1195013 7.7 % 21/12/2015
Wellington Management Company LLP Massachusetts 0 1595000 0 0 1629900 11.14 % 10/07/2015
Wellington Investment Advisors Holdings LLP Massachusetts 0 1604300 0 0 1646700 11.26 % 10/07/2015
Wellington Management Company LLP Massachusetts 0 1595000 0 0 1629900 11.14 % 10/07/2015
Wellington Management Group LLP Massachusetts 0 1604300 0 0 1646700 11.26 % 10/07/2015
Wellington Investment Advisors Holdings LLP Massachusetts 0 1604300 0 0 1646700 11.26 % 10/07/2015
Wellington Group Holdings LLP Massachusetts 0 1604300 0 0 1646700 11.26 % 10/07/2015
Wellington Management Group LLP Massachusetts 0 1604300 0 0 1646700 11.26 % 10/07/2015
Wellington Group Holdings LLP Massachusetts 0 1604300 0 0 1646700 11.26 % 10/07/2015

Senat trading

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Senat Divulgation

Représentant Date de la transaction Date de divulgation Type Amount District