| Millennium Management LLC |
Delaware |
0 |
144153 |
0 |
144153 |
144153 |
0.2 % |
16/10/2024 |
| Millennium Group Management LLC |
Delaware |
0 |
144153 |
0 |
144153 |
144153 |
0.2 % |
16/10/2024 |
| Israel A. Englander |
United States |
0 |
144153 |
0 |
144153 |
144153 |
0.2 % |
16/10/2024 |
| Kevin Tang |
united states |
|
2750000 |
0 |
2750000 |
2750000 |
5.1 % |
14/02/2024 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
|
2750000 |
0 |
2750000 |
2750000 |
5.1 % |
14/02/2024 |
| Tang Capital Management, LLC |
DELAWARE |
|
2750000 |
0 |
2750000 |
2750000 |
5.1 % |
14/02/2024 |
| Teachers Advisors, LLC |
Delaware |
171273 |
0 |
171273 |
0 |
171273 |
0.32 % |
14/02/2024 |
| Nuveen Asset Management, LLC |
Delaware |
6679 |
0 |
6679 |
0 |
6679 |
0.01 % |
14/02/2024 |
| Investment Management, LLC |
Delaware |
1549364 |
0 |
1549364 |
0 |
1549364 |
2.88 % |
14/02/2024 |
| Nuveen Asset Management, LLC |
Delaware |
6679 |
0 |
6679 |
0 |
6679 |
0.01 % |
14/02/2024 |
| Teachers Advisors, LLC |
Delaware |
171273 |
0 |
171273 |
0 |
171273 |
0.32 % |
14/02/2024 |
| Investment Management, LLC |
Delaware |
1549364 |
0 |
1549364 |
0 |
1549364 |
2.88 % |
14/02/2024 |
| Nuveen Asset Management, LLC |
Delaware |
6679 |
0 |
6679 |
0 |
6679 |
0.01 % |
14/02/2024 |
| Teachers Advisors, LLC |
Delaware |
171273 |
0 |
171273 |
0 |
171273 |
0.32 % |
14/02/2024 |
| Investment Management, LLC |
Delaware |
1549364 |
0 |
1549364 |
0 |
1549364 |
2.88 % |
14/02/2024 |
| Threadneedle Holdings Limited |
England and Wales |
0 |
4013211 |
0 |
4013211 |
4013211 |
7.47 % |
14/02/2024 |
| TC Financing Ltd |
England and Wales |
0 |
4013211 |
0 |
4013211 |
4013211 |
7.47 % |
14/02/2024 |
| Threadneedle Asset Management Limited |
England and Wales |
0 |
4013211 |
0 |
4013211 |
4013211 |
7.47 % |
14/02/2024 |
| TAM UK Holdings Limited |
England and Wales |
0 |
4013211 |
0 |
4013211 |
4013211 |
7.47 % |
14/02/2024 |
| No. |
Delaware |
0 |
4183439 |
0 |
4183682 |
4183682 |
7.79 % |
14/02/2024 |
| Threadneedle Investment Services Limited |
England and Wales |
0 |
4013211 |
0 |
4013211 |
4013211 |
7.47 % |
14/02/2024 |
| Threadneedle Asset Management Holdings Limited |
England and Wales |
0 |
4013211 |
0 |
4013211 |
4013211 |
7.47 % |
14/02/2024 |
| TAM UK International Holdings Limited |
England and Wales |
0 |
4013211 |
0 |
4013211 |
4013211 |
7.47 % |
14/02/2024 |
| Michael Gregory |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
| David Witzke |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
| Avidity Master Fund LP |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
| Avidity Capital Partners Fund |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
| Avidity Partners Management LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
| Avidity Partners Management |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
| Avidity Capital Partners |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
| The Vanguard Group |
Pennsylvania |
0 |
24114 |
3529736 |
42236 |
3571972 |
6.65 % |
13/02/2024 |
| Janus Henderson Group plc EIN |
Jersey, Channel Islands |
0 |
273 |
0 |
273 |
273 |
0 % |
12/02/2024 |
| BlackRock, Inc. |
Delaware |
3976066 |
0 |
4044707 |
0 |
4044707 |
7.5 % |
26/01/2024 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
965206 |
0 |
1014546 |
1014546 |
1.89 % |
23/01/2024 |
| STATE STREET CORPORATION NO. OF THE ABOVE PERSON: |
BOSTON MASSACHUSETTS |
0 |
769773 |
0 |
804073 |
804073 |
1.63 % |
10/07/2023 |
| Investment Management, LLC |
Delaware |
3265963 |
0 |
3265963 |
0 |
3265963 |
6.64 % |
12/04/2023 |
| Teachers Advisors, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/04/2023 |
| Teachers Advisors, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/04/2023 |
| Investment Management, LLC |
Delaware |
3265963 |
0 |
3265963 |
0 |
3265963 |
6.64 % |
12/04/2023 |
| Teachers Advisors, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2023 |
| Teachers Advisors, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2023 |
| Investment Management, LLC |
Delaware |
3265963 |
0 |
3265963 |
0 |
3265963 |
7.56 % |
14/02/2023 |
| Investment Management, LLC |
Delaware |
3265963 |
0 |
3265963 |
0 |
3265963 |
7.56 % |
14/02/2023 |
| The Vanguard Group |
Pennsylvania |
0 |
12608 |
2481192 |
51228 |
2532420 |
5.15 % |
09/02/2023 |
| SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
5734424 |
0 |
5734424 |
5734424 |
11.67 % |
10/01/2023 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
5906988 |
0 |
5914588 |
5914588 |
12.03 % |
10/01/2023 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
|
|
|
|
2650000 |
6.13 % |
07/07/2022 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
|
|
|
|
2650000 |
6.13 % |
07/07/2022 |
| Cormorant Asset Management, LP |
Delaware |
|
|
|
|
2650000 |
6.13 % |
07/07/2022 |
| Bihua Chen |
United States |
|
|
|
|
2650000 |
6.13 % |
07/07/2022 |
| Bihua Chen |
United States |
|
|
|
|
2650000 |
6.13 % |
07/07/2022 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
|
|
|
|
2650000 |
6.13 % |
07/07/2022 |
| Cormorant Asset Management, LP |
Delaware |
|
|
|
|
2650000 |
6.13 % |
07/07/2022 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
|
|
|
|
2650000 |
6.13 % |
07/07/2022 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
635344 |
0 |
691141 |
691141 |
1.6 % |
11/04/2022 |
| Kevin Tang |
united states |
|
2200000 |
0 |
2200000 |
2200000 |
5.1 % |
24/03/2022 |
| Kevin Tang |
united states |
|
2200000 |
0 |
2200000 |
2200000 |
5.1 % |
24/03/2022 |
| Tang Capital Management, LLC |
DELAWARE |
|
2200000 |
0 |
2200000 |
2200000 |
5.1 % |
24/03/2022 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
|
2200000 |
0 |
2200000 |
2200000 |
5.1 % |
24/03/2022 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
|
2200000 |
0 |
2200000 |
2200000 |
5.1 % |
24/03/2022 |
| Tang Capital Management, LLC |
DELAWARE |
|
2200000 |
0 |
2200000 |
2200000 |
5.1 % |
24/03/2022 |
| VHCP Management II, LLC |
Delaware |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| Koh, Bong |
United States |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| Shah, Nimish |
United States |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| VHCP Holdings II, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| Venrock Healthcare Capital Partners III, L.P. 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| VHCP Holdings III, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| VHCP Management II, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| VHCP Management III, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| Shah, Nimish 2. Check the Appropriate Box if a Member of a Group |
United States |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| Koh, Bong 2. Check the Appropriate Box if a Member of a Group |
United States |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| VHCP CoInvestment Holdings II, LLC |
Delaware |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| VHCP Management III, LLC |
Delaware |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| VHCP CoInvestment Holdings III, LLC |
Delaware |
0 |
17608702 |
0 |
17608702 |
17608702 |
4.2 % |
14/02/2022 |
| Julian C. Baker |
United States |
1941604 |
0 |
1941604 |
0 |
1941604 |
4.8 % |
14/02/2022 |
| Baker Bros. Advisors LLC |
Delaware |
1941604 |
0 |
1941604 |
0 |
1941604 |
4.8 % |
14/02/2022 |
| Baker Bros. Advisors LP |
Delaware |
1941604 |
0 |
1941604 |
0 |
1941604 |
4.8 % |
14/02/2022 |
| Felix J. Baker |
United States |
1941604 |
0 |
1941604 |
0 |
1941604 |
4.8 % |
14/02/2022 |
| Baker Bros. Advisors LLC |
Delaware |
1941604 |
0 |
1941604 |
0 |
1941604 |
4.8 % |
14/02/2022 |
| Felix J. Baker |
United States |
1941604 |
0 |
1941604 |
0 |
1941604 |
4.8 % |
14/02/2022 |
| Julian C. Baker |
United States |
1941604 |
0 |
1941604 |
0 |
1941604 |
4.8 % |
14/02/2022 |
| Baker Bros. Advisors LP |
Delaware |
1941604 |
0 |
1941604 |
0 |
1941604 |
4.8 % |
14/02/2022 |
| Sphera Healthcare US Inc. |
Israel |
0 |
1244241 |
0 |
1244241 |
1244241 |
3.13 % |
14/02/2022 |
| Sphera Global Healthcare Management LP |
Israel |
0 |
1244241 |
0 |
1244241 |
1244241 |
3.13 % |
14/02/2022 |
| Sphera Healthcare US Inc. |
Israel |
0 |
1244241 |
0 |
1244241 |
1244241 |
3.13 % |
14/02/2022 |
| Sphera Global Healthcare GP Ltd. |
Israel |
0 |
1244241 |
0 |
1244241 |
1244241 |
3.13 % |
14/02/2022 |
| Sphera Funds Management Ltd. |
Israel |
0 |
1244241 |
0 |
1244241 |
1244241 |
3.13 % |
14/02/2022 |
| Sphera Global Healthcare Management LP |
Israel |
0 |
1244241 |
0 |
1244241 |
1244241 |
3.13 % |
14/02/2022 |
| Sphera Funds Management Ltd. |
Israel |
0 |
1244241 |
0 |
1244241 |
1244241 |
3.13 % |
14/02/2022 |
| Sphera Global Healthcare GP Ltd. |
Israel |
0 |
1244241 |
0 |
1244241 |
1244241 |
3.13 % |
14/02/2022 |
| Investment Management, LLC |
Delaware |
2209804 |
0 |
2209804 |
0 |
2209804 |
5.76 % |
11/02/2022 |
| Teachers Advisors, LLC |
Delaware |
86028 |
0 |
86028 |
0 |
86028 |
0.22 % |
11/02/2022 |
| Investment Management, LLC |
Delaware |
2209804 |
0 |
2209804 |
0 |
2209804 |
5.76 % |
11/02/2022 |
| Teachers Advisors, LLC |
Delaware |
86028 |
0 |
86028 |
0 |
86028 |
0.22 % |
11/02/2022 |
| Avidity Partners Management |
Delaware |
0 |
2765000 |
0 |
2765000 |
2765000 |
7 % |
03/01/2022 |
| Avidity Partners Management LP |
Delaware |
0 |
2765000 |
0 |
2765000 |
2765000 |
7 % |
03/01/2022 |
| Avidity Capital Partners |
Delaware |
0 |
2765000 |
0 |
2765000 |
2765000 |
7 % |
03/01/2022 |
| Avidity Master Fund LP |
Cayman Islands |
0 |
2198946 |
0 |
2198946 |
2198946 |
5.5 % |
03/01/2022 |
| David Witzke |
United States of America |
0 |
2765000 |
0 |
2765000 |
2765000 |
7 % |
03/01/2022 |
| Michael Gregory |
United States of America |
0 |
2765000 |
0 |
2765000 |
2765000 |
7 % |
03/01/2022 |
| Avidity Partners Management LP |
Delaware |
0 |
2765000 |
0 |
2765000 |
2765000 |
7 % |
03/01/2022 |
| Avidity Partners Management |
Delaware |
0 |
2765000 |
0 |
2765000 |
2765000 |
7 % |
03/01/2022 |
| Avidity Capital Partners Fund |
Delaware |
0 |
2765000 |
0 |
2765000 |
2765000 |
7 % |
03/01/2022 |
| Avidity Capital Partners |
Delaware |
0 |
2765000 |
0 |
2765000 |
2765000 |
7 % |
03/01/2022 |
| Avidity Master Fund LP |
Cayman Islands |
0 |
2198946 |
0 |
2198946 |
2198946 |
5.5 % |
03/01/2022 |
| David Witzke |
United States of America |
0 |
2765000 |
0 |
2765000 |
2765000 |
7 % |
03/01/2022 |
| Michael Gregory |
United States of America |
0 |
2765000 |
0 |
2765000 |
2765000 |
7 % |
03/01/2022 |
| Avidity Capital Partners Fund |
Delaware |
0 |
2765000 |
0 |
2765000 |
2765000 |
7 % |
03/01/2022 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
3940144 |
0 |
3991141 |
3991141 |
10.05 % |
10/09/2021 |
| SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
3445121 |
0 |
3454021 |
3454021 |
8.7 % |
10/09/2021 |
| Sphera Funds Management Ltd. |
Israel |
0 |
3775618 |
0 |
3775618 |
3775618 |
8.84 % |
31/08/2021 |
| Sphera Global Healthcare Management LP |
Israel |
0 |
3775618 |
0 |
3775618 |
3775618 |
8.84 % |
31/08/2021 |
| Sphera Global Healthcare Management LP |
Israel |
0 |
3775618 |
0 |
3775618 |
3775618 |
8.84 % |
31/08/2021 |
| Sphera Funds Management Ltd. |
Israel |
0 |
3775618 |
0 |
3775618 |
3775618 |
8.84 % |
31/08/2021 |
| Sphera Global Healthcare GP Ltd. |
Israel |
0 |
3775618 |
0 |
3775618 |
3775618 |
8.84 % |
31/08/2021 |
| Sphera Global Healthcare GP Ltd. |
Israel |
0 |
3775618 |
0 |
3775618 |
3775618 |
8.84 % |
31/08/2021 |
| Koh, Bong 2. Check the Appropriate Box if a Member of a Group |
United States |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| Shah, Nimish 2. Check the Appropriate Box if a Member of a Group |
United States |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| VHCP Management III, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| VHCP Management II, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| Venrock Healthcare Capital Partners III, L.P. 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| VHCP Holdings II, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| Koh, Bong 2. Check the Appropriate Box if a Member of a Group |
United States |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| Shah, Nimish 2. Check the Appropriate Box if a Member of a Group |
United States |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| VHCP Management III, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| VHCP Management II, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| VHCP Holdings III, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| Venrock Healthcare Capital Partners III, L.P. 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| VHCP Holdings II, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| VHCP Holdings III, LLC 2. Check the Appropriate Box if a Member of a Group |
Delaware |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
36229642 |
0 |
36229642 |
36229642 |
9.99 % |
01/03/2021 |
| James Watson |
U.S.A. |
0 |
1938335 |
0 |
1938335 |
1938335 |
5.9 % |
16/02/2021 |
| David J. Collier |
U.S.A. |
0 |
1938335 |
0 |
1938335 |
1938335 |
5.9 % |
16/02/2021 |
| Velocity Pharma Management, LLC |
State of Delaware |
0 |
1938335 |
0 |
1938335 |
1938335 |
5.9 % |
16/02/2021 |
| Velocity Pharmaceutical Holdings LLC |
State of Delaware |
0 |
1938335 |
0 |
1938335 |
1938335 |
5.9 % |
16/02/2021 |
| Baker Bros. Advisors LP |
Delaware |
1884451 |
0 |
1884451 |
0 |
1884451 |
5.1 % |
16/02/2021 |
| Baker Bros. Advisors |
Delaware |
1884451 |
0 |
1884451 |
0 |
1884451 |
5.1 % |
16/02/2021 |
| Felix J. Baker |
United States |
1884451 |
0 |
1884451 |
0 |
1884451 |
5.1 % |
16/02/2021 |
| Julian C. Baker |
United States |
1884451 |
0 |
1884451 |
0 |
1884451 |
5.1 % |
16/02/2021 |
| David E. Shaw |
United States |
0 |
1168394 |
0 |
1193694 |
1193694 |
3.6 % |
16/02/2021 |
| D. E. Shaw & Co., L.P. |
Delaware |
0 |
1168394 |
0 |
1193694 |
1193694 |
3.6 % |
16/02/2021 |
| D. E. Shaw & Co., L.P. |
Delaware |
0 |
1634211 |
0 |
1656811 |
1656811 |
5 % |
05/10/2020 |
| David E. Shaw |
United States |
0 |
1634211 |
0 |
1656811 |
1656811 |
5 % |
05/10/2020 |
| David E. Shaw |
United States |
0 |
1634211 |
0 |
1656811 |
1656811 |
5 % |
05/10/2020 |
| D. E. Shaw & Co., L.P. |
Delaware |
0 |
1634211 |
0 |
1656811 |
1656811 |
5 % |
05/10/2020 |
| D. E. Shaw & Co., L.P. |
Delaware |
0 |
1634730 |
0 |
1655330 |
1655330 |
5 % |
24/09/2020 |
| David E. Shaw |
United States |
0 |
1634730 |
0 |
1655330 |
1655330 |
5 % |
24/09/2020 |
| D. E. Shaw & Co., L.P. |
Delaware |
0 |
1634730 |
0 |
1655330 |
1655330 |
5 % |
24/09/2020 |
| David E. Shaw |
United States |
0 |
1634730 |
0 |
1655330 |
1655330 |
5 % |
24/09/2020 |
| VHCP Management II, LLC |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| VHCP CoInvestment Holdings II, LLC |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| VHCP CoInvestment Holdings III, LLC |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| Koh, Bong |
United States |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| Shah, Nimish |
United States |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| VHCP Management III, LLC |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| VHCP Management II, LLC |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| VHCP CoInvestment Holdings III, LLC |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| VHCP CoInvestment Holdings II, LLC |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| Koh, Bong |
United States |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| Shah, Nimish |
United States |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| VHCP Management III, LLC |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
19.3 % |
01/06/2020 |
| Velocity Pharma Management, LLC |
State of Delaware |
0 |
1887250 |
0 |
1887250 |
1887250 |
12.3 % |
14/02/2020 |
| David J. Collier |
U.S.A. |
0 |
1887250 |
0 |
1887250 |
1887250 |
12.3 % |
14/02/2020 |
| James Watson |
U.S.A. |
0 |
1887250 |
0 |
1887250 |
1887250 |
12.3 % |
14/02/2020 |
| Velocity Pharmaceutical Holdings LLC |
State of Delaware |
0 |
1887250 |
0 |
1887250 |
1887250 |
12.3 % |
14/02/2020 |
| Mitchell P. Kopin |
United States America |
0 |
496355 |
0 |
496355 |
496355 |
3.1 % |
11/02/2020 |
| Mitchell P. Kopin |
United States of America |
0 |
496355 |
0 |
496355 |
496355 |
3.1 % |
11/02/2020 |
| Intracoastal Capital LLC |
Delaware |
0 |
496355 |
0 |
496355 |
496355 |
3.1 % |
11/02/2020 |
| Daniel B. Asher |
United States America |
0 |
496355 |
0 |
496355 |
496355 |
3.1 % |
11/02/2020 |
| Daniel B. Asher |
United States of America |
0 |
496355 |
0 |
496355 |
496355 |
3.1 % |
11/02/2020 |
| Intracoastal Capital LLC |
Delaware |
0 |
496355 |
0 |
496355 |
496355 |
3.1 % |
11/02/2020 |
| Sander Gerber |
United States |
0 |
1702336 |
0 |
1702336 |
1702336 |
9.99 % |
31/01/2020 |
| Hudson Bay Capital Management LP |
State of Delaware |
0 |
1702336 |
0 |
1702336 |
1702336 |
9.99 % |
31/01/2020 |
| Hudson Bay Capital Management LP |
State of Delaware |
0 |
1702336 |
0 |
1702336 |
1702336 |
9.99 % |
31/01/2020 |
| Sander Gerber |
United States |
0 |
1702336 |
0 |
1702336 |
1702336 |
9.99 % |
31/01/2020 |
| Heights Capital Management, Inc. |
|
|
|
|
|
459833 |
4.9 % |
14/02/2019 |
| CVI Investments, Inc. |
|
|
|
|
|
459833 |
4.9 % |
14/02/2019 |
| CVI Investments, Inc. |
|
|
|
|
|
459833 |
4.9 % |
14/02/2019 |
| Heights Capital Management, Inc. |
|
|
|
|
|
459833 |
4.9 % |
14/02/2019 |
| Daniel B. Asher |
United States America |
0 |
551264 |
0 |
551264 |
551264 |
6 % |
08/02/2019 |
| Intracoastal Capital LLC |
Delaware |
0 |
551264 |
0 |
551264 |
551264 |
6 % |
08/02/2019 |
| Mitchell P. Kopin |
United States America |
0 |
551264 |
0 |
551264 |
551264 |
6 % |
08/02/2019 |
| Mitchell P. Kopin |
United States America |
0 |
551264 |
0 |
551264 |
551264 |
6 % |
08/02/2019 |
| Daniel B. Asher |
United States America |
0 |
551264 |
0 |
551264 |
551264 |
6 % |
08/02/2019 |
| Intracoastal Capital LLC |
Delaware |
0 |
551264 |
0 |
551264 |
551264 |
6 % |
08/02/2019 |
| Novartis Bioventures Ltd. |
Switzerland |
0 |
309216 |
0 |
309216 |
309216 |
3.5 % |
05/02/2019 |
| Novartis AG |
Switzerland |
0 |
309216 |
0 |
309216 |
309216 |
3.5 % |
05/02/2019 |
| Hudson Bay Capital Management LP |
State of Delaware |
0 |
971492 |
0 |
971492 |
971492 |
9.99 % |
01/02/2019 |
| Sander Gerber |
United States |
0 |
971492 |
0 |
971492 |
971492 |
9.99 % |
01/02/2019 |
| Hudson Bay Capital Management LP |
State of Delaware |
0 |
971492 |
0 |
971492 |
971492 |
9.99 % |
01/02/2019 |
| Sander Gerber |
United States |
0 |
971492 |
0 |
971492 |
971492 |
9.99 % |
01/02/2019 |
| Daniel B. Asher |
United States of America |
0 |
562264 |
0 |
562264 |
562264 |
7.6 % |
17/10/2018 |
| Intracoastal Capital LLC |
United States of America |
0 |
562264 |
0 |
562264 |
562264 |
7.6 % |
17/10/2018 |
| Intracoastal Capital LLC |
United States of America |
0 |
562264 |
0 |
562264 |
562264 |
7.6 % |
17/10/2018 |
| Mitchell P. Kopin |
United States of America |
0 |
562264 |
0 |
562264 |
562264 |
7.6 % |
17/10/2018 |
| Mitchell P. Kopin |
United States of America |
0 |
562264 |
0 |
562264 |
562264 |
7.6 % |
17/10/2018 |
| Daniel B. Asher |
United States of America |
0 |
562264 |
0 |
562264 |
562264 |
7.6 % |
17/10/2018 |
| Heights Capital Management, Inc. |
|
|
|
|
|
252554 |
9.9 % |
05/10/2018 |
| Heights Capital Management, Inc. |
|
|
|
|
|
252554 |
9.9 % |
05/10/2018 |
| CVI Investments, Inc. |
|
|
|
|
|
252554 |
9.9 % |
05/10/2018 |
| CVI Investments, Inc. |
|
|
|
|
|
252554 |
9.9 % |
05/10/2018 |
| Novartis Bioventures Ltd. |
Switzerland |
0 |
278190 |
0 |
278190 |
278190 |
6.8 % |
04/10/2018 |
| Novartis AG |
Switzerland |
0 |
278190 |
0 |
278190 |
278190 |
6.8 % |
04/10/2018 |
| Renaissance Technologies LLC |
Delaware |
541484 |
0 |
541484 |
87133 |
628617 |
4.02 % |
14/02/2018 |
| RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION |
Delaware |
541484 |
0 |
541484 |
87133 |
628617 |
4.02 % |
14/02/2018 |
| OFCO Club V |
Sweden |
0 |
20508 |
0 |
20508 |
20508 |
0.1 % |
12/02/2018 |
| HealthCap V, L.P. |
Delaware |
0 |
1347409 |
0 |
1347409 |
1347409 |
7 % |
12/02/2018 |
| Truffle Capital S.A.S. |
France |
1983597 |
0 |
1983597 |
0 |
1980597 |
10.3 % |
09/02/2018 |
| Novartis Bioventures Ltd. |
Switzerland |
0 |
3775341 |
0 |
3775341 |
3775341 |
18.4 % |
02/02/2018 |
| Novartis AG |
Switzerland |
0 |
3775341 |
0 |
3775341 |
3775341 |
18.4 % |
02/02/2018 |
| Hudson Bay Capital Management LP |
State of Delaware |
0 |
1823142 |
0 |
1823142 |
1823142 |
9.99 % |
02/02/2018 |
| Sander Gerber |
United States |
0 |
1823142 |
0 |
1823142 |
1823142 |
9.99 % |
02/02/2018 |
| Novartis AG |
Switzerland |
0 |
3084551 |
0 |
3084551 |
3084551 |
19.9 % |
23/08/2017 |
| Novartis Bioventures Ltd. |
Bermuda |
0 |
3084551 |
0 |
3084551 |
3084551 |
19.9 % |
23/08/2017 |
| HealthCap V, L.P. |
Delaware |
0 |
1164190 |
0 |
1164190 |
1164190 |
7.5 % |
15/05/2017 |
| OFCO Club V |
Sweden |
0 |
17715 |
0 |
17715 |
17715 |
0.1 % |
15/05/2017 |
| Truffle Capital S.A.S. |
France |
1560946 |
0 |
1560946 |
0 |
1560946 |
10.1 % |
15/05/2017 |
| Novartis AG |
Switzerland |
0 |
1867854 |
0 |
1867854 |
1867854 |
11.1 % |
08/05/2017 |
| Novartis Bioventures Ltd. |
Bermuda |
0 |
1867854 |
0 |
1867854 |
1867854 |
11.1 % |
08/05/2017 |
| Wilmot B. Harkey |
USA |
0 |
3202045 |
0 |
3202045 |
3202045 |
4.8 % |
14/02/2017 |
| Daniel Mack |
USA |
0 |
3202045 |
0 |
3202045 |
3202045 |
4.8 % |
14/02/2017 |
| Nantahala Capital Management, LLC |
MA |
0 |
3202045 |
0 |
3202045 |
3202045 |
4.8 % |
14/02/2017 |
| RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION |
Delaware |
1659704 |
0 |
2502591 |
844550 |
3347141 |
5.02 % |
14/02/2017 |
| Renaissance Technologies LLC |
Delaware |
1659704 |
0 |
2502591 |
844550 |
3347141 |
5.02 % |
14/02/2017 |
| JFL Capital Management LLC |
Delaware, U.S. |
721197 |
3315203 |
721 |
3315203 |
3315203 |
5.05 % |
19/10/2016 |
| Daniel Mack |
USA |
0 |
3389364 |
0 |
3389364 |
3389364 |
5.3 % |
16/02/2016 |
| Wilmot B. Harkey |
USA |
0 |
3389364 |
0 |
3389364 |
3389364 |
5.3 % |
16/02/2016 |
| Nantahala Capital Management, LLC |
MA |
0 |
3389364 |
0 |
3389364 |
3389364 |
5.3 % |
16/02/2016 |
| Prescott Group Capital Management, L.L.C. |
State of Oklahoma |
7966035 |
0 |
7966035 |
0 |
7966035 |
14.1 % |
18/08/2014 |
| Prescott Group Aggressive Small Cap, L.P. |
State of Oklahoma |
0 |
7966035 |
0 |
7966035 |
7966035 |
14.1 % |
18/08/2014 |
| Prescott Group Aggressive Small Cap II, L.P. |
State of Oklahoma |
0 |
7966035 |
0 |
7966035 |
7966035 |
14.1 % |
18/08/2014 |
| Phil Frohlich |
U.S. Citizen |
7966035 |
0 |
7966035 |
0 |
7966035 |
14.1 % |
18/08/2014 |
| Prescott Group Aggressive Small Cap, L.P. |
State of Oklahoma |
0 |
5244835 |
0 |
5244835 |
5244835 |
9.8 % |
02/04/2014 |
| Prescott Group Aggressive Small Cap II, L.P. |
State of Oklahoma |
0 |
5244835 |
0 |
5244835 |
5244835 |
9.8 % |
02/04/2014 |
| Phil Frohlich |
U.S. Citizen |
5244835 |
0 |
5244835 |
0 |
5244835 |
9.8 % |
02/04/2014 |
| Prescott Group Capital Management, L.L.C. |
State of Oklahoma |
5244835 |
0 |
5244835 |
0 |
5244835 |
9.8 % |
02/04/2014 |
| John W. Littlechild |
United States |
5723 |
280998 |
5723 |
280998 |
286721 |
0.6 % |
05/10/2011 |
| Augustine Lawlor |
United States |
3538 |
280998 |
3538 |
280998 |
284536 |
0.6 % |
05/10/2011 |
| HealthCare Ventures VII, L.P. |
United States |
0 |
280998 |
0 |
280998 |
280998 |
0.6 % |
05/10/2011 |
| HealthCare Partners VII, L.P. |
United States |
0 |
280998 |
0 |
280998 |
280998 |
0.6 % |
05/10/2011 |
| James H. Cavanaugh, Ph.D. |
United States |
77816 |
280998 |
77816 |
280998 |
358814 |
0.7 % |
05/10/2011 |
| Christopher Mirabelli, Ph.D. |
United States |
5361 |
280998 |
5361 |
280998 |
286359 |
0.6 % |
05/10/2011 |
| Harold R. Werner |
United States |
7045 |
280998 |
7045 |
280998 |
288043 |
0.6 % |
05/10/2011 |
| HealthCare Ventures VII, L.P. |
United States |
0 |
4534055 |
0 |
4534055 |
4534055 |
9.6 % |
31/01/2011 |
| James H. Cavanaugh, Ph.D. |
United States |
72759 |
4534055 |
72759 |
4534055 |
4606814 |
9.8 % |
31/01/2011 |
| Augustine Lawlor |
United States |
0 |
4534055 |
0 |
4534055 |
4534055 |
9.6 % |
31/01/2011 |
| John W. Littlechild |
United States |
0 |
4534055 |
0 |
4534055 |
4534055 |
9.6 % |
31/01/2011 |
| Harold R. Werner |
United States |
1655 |
4534055 |
1655 |
4534055 |
4535710 |
9.6 % |
31/01/2011 |
| Christopher Mirabelli, Ph.D. |
United States |
0 |
4534055 |
0 |
4534055 |
4534055 |
9.6 % |
31/01/2011 |
| HealthCare Partners VII, L.P. |
United States |
0 |
4534055 |
0 |
4534055 |
4534055 |
9.6 % |
31/01/2011 |
| Eric B. Swergold |
United States |
0 |
834480 |
0 |
834480 |
834480 |
0 % |
28/01/2011 |
| Jon D. Gruber |
United States |
263087 |
834480 |
263087 |
834480 |
1097567 |
2.6 % |
28/01/2011 |
| Gruber and McBaine Capital Management, LLC. |
California |
0 |
834480 |
0 |
834480 |
834480 |
0 % |
28/01/2011 |
| J. Patterson McBaine |
United States |
261977 |
834480 |
261977 |
834480 |
1096457 |
2.6 % |
28/01/2011 |
| Martin D. Hoe |
United States |
0 |
205128 |
0 |
205128 |
205128 |
3.72 % |
18/01/2011 |
| Empery Asset Management, LP |
Delaware |
0 |
205128 |
0 |
205128 |
205128 |
3.72 % |
18/01/2011 |
| Ryan M. Lane |
United States |
0 |
205128 |
0 |
205128 |
205128 |
3.72 % |
18/01/2011 |
| Empery Asset Management, LP |
Delaware |
0 |
2685245 |
0 |
2685245 |
2685245 |
8.6 % |
30/07/2010 |
| Martin D. Hoe |
United States |
0 |
2685245 |
0 |
2685245 |
2685245 |
8.6 % |
30/07/2010 |
| Ryan M. Lane |
United States |
0 |
2685245 |
0 |
2685245 |
2685245 |
8.6 % |
30/07/2010 |
| Empery Asset Management, LP |
Delaware |
0 |
1504139 |
0 |
1504139 |
1504139 |
4.9 % |
19/04/2010 |
| Martin D. Hoe |
United States |
0 |
1504139 |
0 |
1504139 |
1504139 |
4.9 % |
19/04/2010 |
| Ryan M. Lane |
United States |
0 |
1504139 |
0 |
1504139 |
1504139 |
4.9 % |
19/04/2010 |
