| Point72 Capital Advisors, Inc. |
Delaware |
0 |
5039846 |
0 |
0 |
5039846 |
6.2 % |
15/10/2024 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
5039846 |
0 |
0 |
5039846 |
6.2 % |
15/10/2024 |
| Steven A. Cohen |
Delaware |
0 |
5039846 |
0 |
0 |
5039846 |
6.2 % |
15/10/2024 |
| but shall be subject to all other provisions of the Act (however, see the notes. |
|
0 |
8749996 |
0 |
8749996 |
9128376 |
6.9 % |
08/02/2024 |
| Logos Global Management LP |
Delaware |
0 |
5800000 |
0 |
5800000 |
5800000 |
11 % |
02/01/2024 |
| Logos GP LLC |
Delaware |
0 |
5800000 |
0 |
5800000 |
5800000 |
11 % |
02/01/2024 |
| Logos Global Management GP LLC |
Delaware |
0 |
5800000 |
0 |
5800000 |
5800000 |
11 % |
02/01/2024 |
| Arsani William |
United States |
0 |
5800000 |
0 |
5800000 |
5800000 |
11 % |
02/01/2024 |
| Logos Global Master Fund LP |
Cayman Islands |
0 |
5800000 |
0 |
5800000 |
5800000 |
11 % |
02/01/2024 |
| Jon M. Plexico |
California |
0 |
9854158 |
0 |
9854158 |
9854158 |
11 % |
24/08/2023 |
| Timothy P. Lynch |
California |
0 |
9854158 |
0 |
9854158 |
9854158 |
11 % |
24/08/2023 |
| Stonepine Capital Management, LLC |
California |
0 |
9854158 |
0 |
9854158 |
9854158 |
11 % |
24/08/2023 |
| Stonepine Capital, L.P. |
California |
0 |
9854158 |
0 |
9854158 |
9854158 |
11 % |
24/08/2023 |
| Blank |
|
0 |
6169471 |
0 |
6169471 |
6169471 |
5 % |
21/08/2023 |
| Master Fund, LP |
|
0 |
6169471 |
0 |
6169471 |
6169471 |
5 % |
21/08/2023 |
| US Fund Management, Inc. |
|
0 |
6169471 |
0 |
6169471 |
6169471 |
5 % |
21/08/2023 |
| Timothy P. Lynch |
California |
0 |
4743162 |
0 |
4743162 |
4743162 |
4.4 % |
28/04/2023 |
| Stonepine Capital, L.P. |
California |
0 |
4743162 |
0 |
4743162 |
4743162 |
4.4 % |
28/04/2023 |
| Stonepine Capital Management, LLC |
California |
0 |
4743162 |
0 |
4743162 |
4743162 |
4.4 % |
28/04/2023 |
| Jon M. Plexico |
California |
0 |
4743162 |
0 |
4743162 |
4743162 |
4.4 % |
28/04/2023 |
| Heights Capital Management, Inc. |
Cayman Islands |
0 |
7000000 |
0 |
7000000 |
7000000 |
6.6 % |
24/04/2023 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
7000000 |
0 |
7000000 |
7000000 |
6.6 % |
24/04/2023 |
| Laurence W. Lytton |
USA |
4435168 |
5020 |
4435168 |
5020 |
4440188 |
11 % |
22/02/2023 |
| Master Fund, LP |
|
0 |
5040329 |
0 |
5040329 |
5040329 |
6.8 % |
14/02/2023 |
| US Fund Management, Inc. |
|
0 |
5040329 |
0 |
5040329 |
5040329 |
6.8 % |
14/02/2023 |
| Chart Westcott |
Delaware |
0 |
35048 |
0 |
35048 |
35048 |
0.1 % |
14/02/2022 |
| Neil Shahrestani |
Delaware |
0 |
35048 |
0 |
35048 |
35048 |
0.1 % |
14/02/2022 |
| Ikarian Capital, LLC |
Delaware |
0 |
35048 |
0 |
35048 |
35048 |
0.1 % |
14/02/2022 |
| VHCP Management EG, LLC |
Delaware |
0 |
1565000 |
0 |
0 |
1565000 |
5.6 % |
14/02/2022 |
| Koh, Bong |
United States |
0 |
1565000 |
0 |
0 |
1565000 |
5.6 % |
14/02/2022 |
| Venrock Healthcare Capital Partners EG, L.P. |
Delaware |
0 |
1565000 |
0 |
0 |
1565000 |
5.6 % |
14/02/2022 |
| Venrock Healthcare Capital Partners II, L.P. |
Delaware |
0 |
1565000 |
0 |
0 |
1565000 |
5.6 % |
14/02/2022 |
| VHCP Management II, LLC |
Delaware |
0 |
1565000 |
0 |
0 |
1565000 |
5.6 % |
14/02/2022 |
| VHCP Co-Investment Holdings III, LLC |
Delaware |
0 |
1565000 |
0 |
0 |
1565000 |
5.6 % |
14/02/2022 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
1565000 |
0 |
0 |
1565000 |
5.6 % |
14/02/2022 |
| VHCP Co-Investment Holdings II, LLC |
Delaware |
0 |
1565000 |
0 |
0 |
1565000 |
5.6 % |
14/02/2022 |
| VHCP Management III, LLC |
Delaware |
0 |
1565000 |
0 |
0 |
1565000 |
5.6 % |
14/02/2022 |
| Shah, Nimish |
United States |
0 |
1565000 |
0 |
0 |
1565000 |
5.6 % |
14/02/2022 |
| Consonance Capman GP LLC |
|
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Consonance Capital Management LP |
|
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Mitchell Blutt |
|
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Highbridge Capital Management, LLC |
|
0 |
4855516 |
0 |
0 |
4855516 |
7.64 % |
11/02/2022 |
| 2. |
Delaware |
0 |
0 |
0 |
18150002 |
18150002 |
6.7 % |
27/09/2021 |
| 2. |
Delaware |
0 |
0 |
0 |
18150002 |
18150002 |
6.7 % |
27/09/2021 |
| 2. |
Delaware |
0 |
0 |
0 |
18150002 |
18150002 |
6.7 % |
27/09/2021 |
| 2. |
Delaware |
0 |
0 |
0 |
18150002 |
18150002 |
6.7 % |
27/09/2021 |
| VHCP Co-Investment Holdings III, LLC |
Delaware |
0 |
0 |
0 |
18150002 |
18150002 |
6.7 % |
27/09/2021 |
| 2. |
Delaware |
0 |
0 |
0 |
18150002 |
18150002 |
6.7 % |
27/09/2021 |
| VHCP Management III, LLC |
Delaware |
0 |
0 |
0 |
0 |
18150002 |
6.7 % |
27/09/2021 |
| 2. |
Delaware |
0 |
0 |
0 |
18150002 |
18150002 |
6.7 % |
27/09/2021 |
| 2. |
Delaware |
0 |
0 |
0 |
18150002 |
18150002 |
6.7 % |
27/09/2021 |
| 2. |
Delaware |
0 |
0 |
0 |
18150002 |
18150002 |
6.7 % |
27/09/2021 |
| 10 |
United States of America |
0 |
717106 |
0 |
717106 |
717106 |
4.2 % |
17/09/2021 |
| 5.3% (1) |
United States of America |
0 |
888580 |
0 |
888580 |
888580 |
5.3 % |
17/09/2021 |
| 10 |
United States of America |
0 |
888580 |
0 |
888580 |
888580 |
5.3 % |
17/09/2021 |
| 10 |
United States of America |
0 |
888580 |
0 |
888580 |
888580 |
5.3 % |
17/09/2021 |
| 10 |
United States of America |
0 |
717106 |
0 |
717106 |
717106 |
4.2 % |
17/09/2021 |
| Novartis AG |
|
0 |
5194054 |
0 |
11 |
5194054 |
8.8 % |
11/03/2021 |
| Novartis Pharma AG |
|
0 |
5194054 |
0 |
11 |
5194054 |
8.8 % |
11/03/2021 |
| Highbridge Capital Management, LLC |
State of Delaware |
0 |
4222972 |
0 |
0 |
4222972 |
6.66 % |
26/02/2021 |
| Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
316913 |
0 |
0 |
316913 |
0.54 % |
17/02/2021 |
| Mitchell Blutt |
Delaware USA |
0 |
3287745 |
0 |
0 |
3287745 |
5.57 % |
17/02/2021 |
| Consonance Capital Management LP |
Delaware USA |
0 |
2970832 |
0 |
0 |
2970832 |
5.04 % |
17/02/2021 |
| Consonance Capman GP LLC |
Delaware USA |
0 |
3287745 |
0 |
0 |
3287745 |
5.57 % |
17/02/2021 |
| Page 10 of 15 Pages |
United States |
0 |
0 |
0 |
1312537 |
1312537 |
9.15 % |
17/02/2021 |
| Page 3 of 15 Pages |
United States |
0 |
0 |
0 |
0 |
1312537 |
9.15 % |
17/02/2021 |
| Page 11 of 15 Pages |
United States |
0 |
0 |
0 |
1312537 |
1312537 |
9.15 % |
17/02/2021 |
| Page 9 of 15 Pages |
United States |
0 |
0 |
0 |
1312537 |
1312537 |
9.15 % |
17/02/2021 |
| Page 6 of 15 Pages |
United States |
0 |
0 |
0 |
1312537 |
1312537 |
9.15 % |
17/02/2021 |
| Page 2 of 15 Pages |
United States |
0 |
0 |
0 |
1312537 |
1312537 |
9.15 % |
17/02/2021 |
| Page 8 of 15 Pages |
United States |
0 |
0 |
0 |
0 |
1312537 |
9.15 % |
17/02/2021 |
| Page 5 of 15 Pages |
United States |
0 |
0 |
0 |
1312537 |
1312537 |
9.15 % |
17/02/2021 |
| Page 7 of 15 Pages |
United States |
0 |
0 |
0 |
1312537 |
1312537 |
9.15 % |
17/02/2021 |
| Page 4 of 15 Pages |
United States |
0 |
0 |
0 |
1312537 |
1312537 |
9.15 % |
17/02/2021 |
| Anand Parekh |
United States of America |
0 |
842554 |
0 |
0 |
842554 |
8.3 % |
16/02/2021 |
| Alyeska Fund GP, LLC |
Delaware |
0 |
842554 |
0 |
0 |
842554 |
8.3 % |
16/02/2021 |
| Alyeska Investment Group, L.P. |
Delaware |
0 |
842554 |
0 |
0 |
842554 |
8.3 % |
16/02/2021 |
| Consonance Capital Management LP |
Delaware USA |
0 |
2970832 |
0 |
0 |
2970832 |
5.04 % |
16/02/2021 |
| Consonance Capman GP LLC |
Delaware USA |
0 |
6058505 |
0 |
0 |
6058505 |
9.99 % |
16/02/2021 |
| Mitchell Blutt |
Delaware USA |
0 |
6058505 |
0 |
0 |
6058505 |
9.99 % |
16/02/2021 |
| Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
1193518 |
0 |
0 |
1193518 |
2.04 % |
16/02/2021 |
| Altium Growth Fund, LP |
United States of America |
0 |
332258 |
0 |
0 |
332258 |
3.2 % |
12/02/2021 |
| Altium Capital Management, LP |
United States of America |
0 |
332258 |
0 |
0 |
332258 |
3.2 % |
12/02/2021 |
| Altium Growth GP, LLC |
United States of America |
0 |
332258 |
0 |
0 |
332258 |
3.2 % |
12/02/2021 |
| Novartis AG |
|
0 |
5194054 |
0 |
11 |
5194054 |
10.3 % |
14/08/2020 |
| Novartis Pharma AG |
|
0 |
5194054 |
0 |
11 |
5194054 |
10.3 % |
14/08/2020 |
| Altium Growth GP, LLC |
Delaware, United States of America |
0 |
475000 |
0 |
0 |
475000 |
5.8 % |
18/02/2020 |
| Altium Capital Management, LP |
Delaware, United States of America |
0 |
475000 |
0 |
0 |
475000 |
5.8 % |
18/02/2020 |
| Altium Growth Fund, LP |
Delaware, United States of America |
0 |
475000 |
0 |
0 |
475000 |
5.8 % |
18/02/2020 |
| 26-0385758 |
Delaware |
199920 |
0 |
199920 |
0 |
199920 |
5.14 % |
12/02/2020 |
| 13-3127734 |
Delaware |
199920 |
0 |
199920 |
0 |
199920 |
5.14 % |
12/02/2020 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
2878270 |
0 |
2878270 |
8.672 % |
07/02/2020 |
| FMR LLC |
Delaware |
8270 |
0 |
2878270 |
0 |
2878270 |
8.672 % |
07/02/2020 |
| JEREMY C. GREEN |
DELAWARE |
0 |
2594339 |
0 |
0 |
2594339 |
8.52 % |
08/03/2018 |
| Redmile Group, LLC |
DELAWARE |
0 |
2594339 |
0 |
0 |
2594339 |
8.52 % |
08/03/2018 |
| EcoR1 Capital, LLC |
Delaware |
0 |
4625519 |
0 |
4625519 |
4625519 |
11 % |
14/02/2018 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
3788888 |
0 |
3788888 |
3788888 |
11 % |
14/02/2018 |
| Oleg Nodelman |
United States |
0 |
4625519 |
0 |
4625519 |
4625519 |
11 % |
14/02/2018 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
1475934 |
0 |
1475934 |
1475934 |
6.2 % |
30/01/2017 |
| EcoR1 Capital, LLC |
Delaware |
0 |
1961335 |
0 |
1961335 |
1961335 |
8.3 % |
30/01/2017 |
| Oleg Nodelman |
Delaware |
0 |
1961335 |
0 |
1961335 |
1961335 |
8.3 % |
30/01/2017 |
| Page 2 of 5 Pages |
Delaware |
1165349 |
0 |
1206249 |
0 |
1206249 |
5.1 % |
12/02/2016 |
| Domain Associates, LLC |
Delaware |
6286 |
0 |
6286 |
0 |
6286 |
0.1 % |
19/01/2016 |
| Domain Partners VIII, L.P. |
Delaware |
1807820 |
0 |
1807820 |
0 |
1807820 |
7.6 % |
19/01/2016 |
| DP VIII Associates, L.P. |
Delaware |
13414 |
0 |
13414 |
0 |
13414 |
0.1 % |
19/01/2016 |
| Dr. Michael F. Powell (“Powell”) |
U.S. Citizen |
0 |
1866126 |
0 |
10 |
1866126 |
8.3 % |
15/05/2015 |
| Sofinnova Venture Partners IX, L.P. (“SVP IX”) |
Delaware |
1866126 |
0 |
1866126 |
10 |
1866126 |
8.3 % |
15/05/2015 |
| Sofinnova Management IX, L.L.C. (“SM IX”) |
Delaware |
1866126 |
0 |
1866126 |
0 |
1866126 |
8.3 % |
15/05/2015 |
| Dr. Srinivas Akkaraju (“Akkaraju”) |
U.S. Citizen |
1047 |
1866126 |
1047 |
10 |
1867173 |
8.3 % |
15/05/2015 |
| Dr. James I. Healy (“Healy”) |
U.S. Citizen |
0 |
1866126 |
0 |
10 |
1866126 |
8.3 % |
15/05/2015 |
| Dr. Anand Mehra (“Mehra”) |
U.S. Citizen |
0 |
1866126 |
0 |
10 |
1866126 |
8.3 % |
15/05/2015 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
255764 |
0 |
0 |
255764 |
1.1 % |
13/05/2015 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
511528 |
0 |
0 |
511528 |
2.19 % |
13/05/2015 |
| Deerfield Mgmt III, L.P. |
Delaware |
0 |
255764 |
0 |
0 |
255764 |
1.1 % |
13/05/2015 |
| James E. Flynn |
Delaware |
0 |
511528 |
0 |
0 |
511528 |
2.19 % |
13/05/2015 |
| Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
255764 |
0 |
0 |
255764 |
1.1 % |
13/05/2015 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
255764 |
0 |
0 |
255764 |
1.1 % |
13/05/2015 |