| Lepu Medical Technology (Beijing) Co., Ltd. |
People’s Republic of China |
102437055 |
0 |
102437055 |
10 |
102437055 |
9.5 % |
26/10/2023 |
| Lepu Medical (Europe) Cooperatief U.A. |
Netherlands |
102437055 |
0 |
102437055 |
10 |
102437055 |
9.5 % |
26/10/2023 |
| Lepu (Hong Kong) Co., Limited |
Hong Kong |
102437055 |
0 |
102437055 |
10 |
102437055 |
9.5 % |
26/10/2023 |
| Lepu Holdings Limited |
British Virgin Islands |
102437055 |
0 |
102437055 |
10 |
102437055 |
9.5 % |
26/10/2023 |
| Hong Seng Technology Limited |
Hong Kong |
102437055 |
0 |
102437055 |
10 |
102437055 |
9.5 % |
26/10/2023 |
| Daniel B. Asher |
United States of America |
0 |
7427625 |
0 |
7427625 |
7427625 |
1 % |
11/02/2022 |
| Mitchell P. Kopin |
United States of America |
0 |
7427625 |
0 |
7427625 |
7427625 |
1 % |
11/02/2022 |
| Intracoastal Capital LLC |
United States of America |
0 |
7427625 |
0 |
7427625 |
7427625 |
1 % |
11/02/2022 |
| Novartis AG |
Switzerland |
0 |
4999995 |
0 |
0 |
4999995 |
1 % |
16/02/2021 |
| Novartis Pharma AG |
Switzerland |
0 |
4999995 |
0 |
0 |
4999995 |
1 % |
16/02/2021 |
| Altium Capital Growth GP, LLC |
Delaware, United State of America |
0 |
18010485 |
0 |
0 |
18010485 |
3.7 % |
12/02/2021 |
| Altium Growth Fund, LP |
Delaware, United State of America |
0 |
18010485 |
0 |
0 |
18010485 |
3.7 % |
12/02/2021 |
| Altium Capital Management, LP |
Delaware, United State of America |
0 |
18010485 |
0 |
0 |
18010485 |
3.7 % |
12/02/2021 |
| Senvest Management, LLC |
Delaware |
0 |
2725005 |
0 |
2725005 |
2725005 |
0.77 % |
12/02/2021 |
| Steven Boyd |
Delaware |
0 |
1038084 |
0 |
1038084 |
1038084 |
4.99 % |
05/06/2020 |
| Armistice Capital, LLC |
Delaware |
0 |
1038084 |
0 |
1038084 |
1038084 |
4.99 % |
05/06/2020 |
| Armistice Capital Master Fund Ltd. |
Delaware |
0 |
1038084 |
0 |
1038084 |
1038084 |
4.99 % |
05/06/2020 |
| Altium Capital Management, LP |
Delaware, United State of America |
0 |
1700699 |
0 |
0 |
1700699 |
8.6 % |
04/06/2020 |
| Altium Growth Fund, LP |
Delaware, United States of America |
0 |
1700699 |
0 |
0 |
1700699 |
8.6 % |
04/06/2020 |
| Altium Capital Growth GP, LLC |
Delaware, United State of America |
0 |
1700699 |
0 |
0 |
1700699 |
8.6 % |
04/06/2020 |
| The Capital Group Companies, Inc. |
United States America |
0 |
19132860 |
0 |
19132860 |
0 |
0 % |
04/06/2020 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
13999725 |
0 |
13999725 |
13999725 |
5.3 % |
01/06/2020 |
| Biotechnology Value Fund II, L.P. |
|
0 |
0 |
0 |
10541415 |
10541415 |
5.9 % |
14/02/2020 |
| BVF Partners L.P. |
|
0 |
0 |
0 |
31942380 |
31942380 |
17.5 % |
14/02/2020 |
| Mark N. Lampert |
|
0 |
0 |
0 |
31942380 |
31942380 |
17.5 % |
14/02/2020 |
| BVF Partners OS Ltd. |
|
0 |
0 |
0 |
2663550 |
2663550 |
1.5 % |
14/02/2020 |
| Biotechnology Value Trading Fund OS LP |
|
0 |
0 |
0 |
2663550 |
2663550 |
1.5 % |
14/02/2020 |
| BVF II GP LLC |
|
0 |
0 |
0 |
10541415 |
10541415 |
5.9 % |
14/02/2020 |
| BVF I GP LLC |
|
0 |
0 |
0 |
13999725 |
13999725 |
7.8 % |
14/02/2020 |
| Biotechnology Value Fund, L.P. |
|
0 |
0 |
0 |
13999725 |
13999725 |
7.8 % |
14/02/2020 |
| BVF GP HOLDINGS LLC |
|
0 |
0 |
0 |
24541140 |
24541140 |
13.5 % |
14/02/2020 |
| BVF Inc. |
|
0 |
0 |
0 |
31942380 |
31942380 |
17.5 % |
14/02/2020 |
| Senvest Management, LLC |
Delaware |
0 |
2725005 |
0 |
0 |
2725005 |
7.87 % |
07/02/2020 |
| Richard Mashaal |
Delaware |
0 |
2725005 |
0 |
0 |
2725005 |
7.87 % |
07/02/2020 |
| Richard Mashaal |
Canada |
0 |
7538845 |
0 |
0 |
7538845 |
5.18 % |
08/02/2019 |
| Senvest Management, LLC |
Delaware |
0 |
7538845 |
0 |
0 |
7538845 |
5.18 % |
08/02/2019 |
| Richard Mashaal |
Canada |
0 |
4813845 |
0 |
0 |
4813845 |
4.19 % |
08/02/2019 |
| Senvest Management, LLC |
Delaware |
0 |
4813845 |
0 |
0 |
4813845 |
4.19 % |
08/02/2019 |
| Richard Mashaal |
Delaware |
0 |
7781641 |
0 |
0 |
7781641 |
7.44 % |
12/02/2018 |
| Senvest Management, LLC |
Delaware |
0 |
7781641 |
0 |
0 |
7781641 |
7.44 % |
12/02/2018 |
| NOVARTIS AG |
SWITZERLAND |
0 |
5000000 |
0 |
0 |
5000000 |
5.2 % |
14/12/2017 |
| NOVARTIS PHARMA AG |
SWITZERLAND |
0 |
5000000 |
0 |
0 |
5000000 |
5.2 % |
14/12/2017 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
17500000 |
17500000 |
18.3 % |
10/04/2017 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
1459936 |
1459936 |
1.5 % |
10/04/2017 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
17500000 |
17500000 |
18.3 % |
10/04/2017 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
8008011 |
8008011 |
8.4 % |
10/04/2017 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
5241310 |
5241310 |
5.5 % |
10/04/2017 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
17500000 |
17500000 |
18.3 % |
10/04/2017 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
1459936 |
1459936 |
1.5 % |
10/04/2017 |
| Senvest Management, LLC |
Delaware |
0 |
349650 |
0 |
0 |
349650 |
9.01 % |
13/02/2017 |
| Richard Mashaal |
Delaware |
0 |
349650 |
0 |
0 |
349650 |
9.01 % |
13/02/2017 |
| OrbiMed Israel BioFund GP Limited Partnership |
Israel |
0 |
2638600 |
0 |
0 |
2638600 |
4.69 % |
16/02/2016 |
| OrbiMed Israel GP Ltd. |
Israel |
0 |
2638600 |
0 |
0 |
2638600 |
4.69 % |
16/02/2016 |
| Senvest Management, LLC |
Delaware |
0 |
3952950 |
0 |
0 |
3952950 |
7.23 % |
12/02/2016 |
| Richard Mashaal |
Delaware |
0 |
3952950 |
0 |
0 |
3952950 |
7.23 % |
12/02/2016 |
| Broadfin Capital, LLC |
Delaware |
0 |
31000000 |
0 |
31000000 |
31000000 |
6 % |
16/03/2015 |
| OrbiMed Israel BioFund GP Limited Partnership |
Israel |
0 |
27350000 |
0 |
0 |
27350000 |
7.7 % |
17/02/2015 |
| OrbiMed Israel GP Ltd. |
Israel |
0 |
27350000 |
0 |
0 |
27350000 |
7.7 % |
17/02/2015 |
| Richard Mashaal |
Canada |
0 |
26286450 |
0 |
26286450 |
26286450 |
6.7 % |
07/01/2015 |
| Rima Senvest Management, L.L.C. |
Canada |
0 |
26286450 |
0 |
26286450 |
26286450 |
6.7 % |
07/01/2015 |
| NOVARTIS AG |
SWITZERLAND |
0 |
50000000 |
0 |
0 |
50000000 |
12.8 % |
19/12/2014 |
| NOVARTIS PHARMA AG |
Switzerland |
0 |
50000000 |
0 |
0 |
50000000 |
12.8 % |
19/12/2014 |
| 9.99% (2) |
Israel |
0 |
25096520 |
0 |
25096520 |
25096520 |
9.99 % |
13/02/2014 |
| 9.99% (2) |
Israel |
0 |
25096520 |
0 |
25096520 |
25096520 |
9.99 % |
13/02/2014 |
| Richard Mashaal |
Delaware |
0 |
7405000 |
0 |
7405000 |
7405000 |
4.03 % |
19/02/2013 |
| Rima Senvest Management, LLC |
Delaware |
0 |
7405000 |
0 |
7405000 |
7405000 |
4.03 % |
19/02/2013 |
| Ruth Manor |
Israel |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| Avraham Livnat |
Israel |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| Clal Insurance Enterprises Holdings Ltd. |
Israel |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| IDB Development Corporation Ltd. |
Israel |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| IDB Holding Corporation Ltd. |
Israel |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| Nochi Dankner |
Israel |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| Shelly Bergman |
Israel |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| Migdal Insurance & Financial Holdings Ltd |
Israel |
0 |
7638907 |
0 |
0 |
7638907 |
4.3 % |
29/03/2012 |
| Richard Mashaal |
Delaware |
0 |
1048950 |
0 |
1048950 |
1048950 |
5.96 % |
20/03/2012 |
| Rima Senvest Management, LLC |
Delaware |
0 |
1048950 |
0 |
1048950 |
1048950 |
5.96 % |
20/03/2012 |
| Migdal Insurance & Financial Holdings Ltd |
Israel |
0 |
7635424 |
0 |
0 |
7635424 |
6.18 % |
14/02/2012 |
| Avraham Livnat |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |
| IDB Holding Corporation Ltd. |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |
| IDB Development Corporation Ltd. |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |
| Nochi Dankner |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |
| Clal Insurance Enterprises Holdings Ltd. |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |
| Shelly Bergman |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |
| Ruth Manor |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |
| IDB Development Corporation Ltd. |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |
| Avraham Livnat |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |
| Shelly Bergman |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |
| Nochi Dankner |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |
| Clal Insurance Enterprises Holdings Ltd. |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |
| IDB Holding Corporation Ltd. |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |
| Ruth Manor |
Israel |
0 |
10683534 |
0 |
0 |
10683534 |
8.64 % |
14/02/2012 |