| Takeda Pharmaceutical Company Limited |
Japan |
0 |
14817484 |
0 |
10 |
14817484 |
13.2 % |
21/04/2022 |
| Millennium Pharmaceuticals, Inc. |
Delaware |
0 |
14817484 |
0 |
10 |
14817484 |
13.2 % |
21/04/2022 |
| 2. |
Delaware |
0 |
41244 |
0 |
0 |
10 |
0 % |
11/04/2022 |
| 2. |
Delaware |
0 |
41244 |
0 |
0 |
10 |
0 % |
11/04/2022 |
| 2. |
Delaware |
0 |
41244 |
0 |
0 |
10 |
0 % |
11/04/2022 |
| 2. |
Delaware |
0 |
4993833 |
0 |
0 |
10 |
5.3 % |
11/04/2022 |
| 2. |
Delaware |
0 |
4993833 |
0 |
0 |
10 |
5.3 % |
11/04/2022 |
| 2. |
Delaware |
0 |
5035077 |
0 |
0 |
10 |
5.4 % |
11/04/2022 |
| 2. |
Delaware |
0 |
4993833 |
0 |
0 |
10 |
5.3 % |
11/04/2022 |
| 2. |
Delaware |
0 |
40814 |
0 |
0 |
10 |
0 % |
11/04/2022 |
| 2. |
Delaware |
0 |
4993833 |
0 |
0 |
10 |
5.3 % |
11/04/2022 |
| 2. |
Delaware |
0 |
4993833 |
0 |
0 |
10 |
5.3 % |
11/04/2022 |
| 2. |
Delaware |
0 |
4993833 |
0 |
0 |
10 |
5.3 % |
11/04/2022 |
| 2. |
Delaware |
0 |
40814 |
0 |
0 |
10 |
0 % |
11/04/2022 |
| 2. |
Delaware |
0 |
41244 |
0 |
0 |
10 |
0 % |
11/04/2022 |
| 2. |
Delaware |
0 |
5035077 |
0 |
0 |
10 |
5.4 % |
11/04/2022 |
| 2. |
|
0 |
3493833 |
0 |
0 |
10 |
4.7 % |
14/02/2022 |
| 2. |
|
0 |
3630548 |
0 |
0 |
10 |
4.8 % |
14/02/2022 |
| 2. |
|
0 |
136715 |
0 |
0 |
10 |
0.2 % |
14/02/2022 |
| 2. |
|
0 |
136715 |
0 |
0 |
10 |
0.2 % |
14/02/2022 |
| 2. |
|
0 |
136715 |
0 |
0 |
10 |
0.2 % |
14/02/2022 |
| 2. |
|
0 |
3493833 |
0 |
0 |
10 |
4.7 % |
14/02/2022 |
| 2. |
|
0 |
3493833 |
0 |
0 |
10 |
4.7 % |
14/02/2022 |
| PRIMECAP Management Company |
|
10733000 |
0 |
10733000 |
0 |
10733000 |
14.32 % |
10/02/2022 |
| PRIMECAP Management Company |
177 E. Colorado Blvd., 11th Floor, Pasadena, CA 91105 |
10733000 |
0 |
10733000 |
0 |
10733000 |
14.32 % |
10/02/2022 |
| Phillip Gross |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2022 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2022 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2022 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2022 |
| Robert Atchinson |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2022 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
1418 |
0 |
1418 |
0 |
1418 |
0 % |
10/12/2021 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
1418 |
0 |
1418 |
1418 |
0 % |
10/12/2021 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
1418 |
0 |
1418 |
1418 |
0 % |
10/12/2021 |
| Federated Hermes, Inc. |
Citizenship or place of Organization |
1418 |
0 |
1418 |
0 |
1418 |
0 % |
10/12/2021 |
| Thomas R. Donahue |
Citizenship or place of Organization |
0 |
1418 |
0 |
1418 |
1418 |
0 % |
10/12/2021 |
| 2. |
Delaware |
0 |
3684143 |
0 |
0 |
10 |
4.9 % |
22/11/2021 |
| 2. |
Delaware |
0 |
3493833 |
0 |
0 |
10 |
4.7 % |
22/11/2021 |
| 2. |
Delaware |
0 |
190310 |
0 |
0 |
10 |
0.3 % |
22/11/2021 |
| 2. |
Delaware |
0 |
190310 |
0 |
0 |
10 |
0.3 % |
22/11/2021 |
| 2. |
Delaware |
0 |
3493833 |
0 |
0 |
10 |
4.7 % |
22/11/2021 |
| 2. |
Delaware |
0 |
3684143 |
0 |
0 |
10 |
4.9 % |
22/11/2021 |
| 2. |
Delaware |
0 |
190310 |
0 |
0 |
10 |
0.3 % |
22/11/2021 |
| 2. |
Delaware |
0 |
3493833 |
0 |
0 |
10 |
4.7 % |
22/11/2021 |
| 2. |
Delaware |
0 |
190310 |
0 |
0 |
10 |
0.3 % |
22/11/2021 |
| 2. |
Delaware |
0 |
190310 |
0 |
0 |
10 |
0.3 % |
22/11/2021 |
| 2. |
Delaware |
0 |
3493833 |
0 |
0 |
10 |
4.7 % |
22/11/2021 |
| 2. |
Delaware |
0 |
3493833 |
0 |
0 |
10 |
4.7 % |
22/11/2021 |
| 2. |
Delaware |
0 |
3493833 |
0 |
0 |
10 |
4.7 % |
22/11/2021 |
| 2. |
Delaware |
0 |
190310 |
0 |
0 |
10 |
0.3 % |
22/11/2021 |
| (1) BlackRock, Inc. |
Delaware |
2691534 |
0 |
2796097 |
0 |
2796097 |
3.8 % |
12/07/2021 |
| Biotechnology Value Fund, L.P. |
Cayman Islands |
0 |
458157 |
0 |
458157 |
3969986 |
5.4 % |
08/07/2021 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
34364 |
0 |
34364 |
34364 |
4 % |
16/02/2021 |
| Steven A. Cohen |
Delaware |
0 |
1734364 |
0 |
1734364 |
1734364 |
4 % |
16/02/2021 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
1700000 |
0 |
1700000 |
1700000 |
4 % |
16/02/2021 |
| Point72 Hong Kong Limited |
Delaware |
0 |
0 |
0 |
0 |
0 |
4 % |
16/02/2021 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
1700000 |
0 |
1700000 |
1700000 |
4 % |
16/02/2021 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
7442600 |
0 |
7442600 |
7442600 |
10.55 % |
12/02/2021 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
7442600 |
0 |
7442600 |
0 |
7442600 |
10.55 % |
12/02/2021 |
| Federated Hermes, Inc. |
Citizenship or place of Organization |
7442600 |
0 |
7442600 |
0 |
7442600 |
10.55 % |
12/02/2021 |
| Thomas R. Donahue |
Citizenship or place of Organization |
0 |
7442600 |
0 |
7442600 |
7442600 |
10.55 % |
12/02/2021 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
7442600 |
0 |
7442600 |
7442600 |
10.55 % |
12/02/2021 |
| BVF Inc. |
|
0 |
0 |
0 |
4361238 |
4361238 |
6.2 % |
11/02/2021 |
| BVF Partners L.P. |
|
0 |
0 |
0 |
4361238 |
4361238 |
6.2 % |
11/02/2021 |
| BVF GP HOLDINGS LLC |
|
0 |
0 |
0 |
3998813 |
3998813 |
5.7 % |
11/02/2021 |
| BVF Partners OS Ltd. |
|
0 |
0 |
0 |
280131 |
280131 |
1 % |
11/02/2021 |
| Biotechnology Value Trading Fund OS LP |
|
0 |
0 |
0 |
280131 |
280131 |
1 % |
11/02/2021 |
| Biotechnology Value Fund, L.P. |
|
0 |
0 |
0 |
2305269 |
2305269 |
3.3 % |
11/02/2021 |
| BVF II GP LLC |
|
0 |
0 |
0 |
1693544 |
1693544 |
2.4 % |
11/02/2021 |
| BVF I GP LLC |
|
0 |
0 |
0 |
2305269 |
2305269 |
3.3 % |
11/02/2021 |
| Biotechnology Value Fund II, L.P. |
|
0 |
0 |
0 |
1693544 |
1693544 |
2.4 % |
11/02/2021 |
| Mark N. Lampert |
|
0 |
0 |
0 |
4361238 |
4361238 |
6.2 % |
11/02/2021 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
142652 |
3494974 |
179720 |
3674694 |
5.21 % |
10/02/2021 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
142652 |
3494974 |
179720 |
3674694 |
5.21 % |
10/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
5518816 |
0 |
5668400 |
0 |
5668400 |
8 % |
28/01/2021 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
5.67 % |
25/01/2021 |
| Robert Atchinson |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
5.67 % |
25/01/2021 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
5.67 % |
25/01/2021 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
5.67 % |
25/01/2021 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
5.67 % |
25/01/2021 |
| Phillip Gross |
United States |
0 |
4000000 |
0 |
0 |
4000000 |
5.67 % |
25/01/2021 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
5.67 % |
25/01/2021 |
| Robert Atchinson |
United States |
0 |
4000000 |
0 |
0 |
4000000 |
5.67 % |
25/01/2021 |
| Phillip Gross |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
5.67 % |
25/01/2021 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
4000000 |
0 |
0 |
4000000 |
5.67 % |
25/01/2021 |
| Point72 Asset Management, L.P. |
United States |
0 |
3240046 |
0 |
3240046 |
3217300 |
4 % |
13/03/2020 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
20885 |
0 |
20885 |
20885 |
4 % |
13/03/2020 |
| Point72 Hong Kong Limited |
Delaware |
0 |
1861 |
0 |
1861 |
1861 |
4 % |
13/03/2020 |
| Steven A. Cohen |
Delaware |
0 |
3240046 |
0 |
3240046 |
3240046 |
4 % |
13/03/2020 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
3217300 |
0 |
3217300 |
3217300 |
4 % |
13/03/2020 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
3217300 |
0 |
3217300 |
3217300 |
4 % |
13/03/2020 |
| Thomas R. Donahue |
Citizenship or place of Organization |
0 |
6934600 |
0 |
6934600 |
6934600 |
12.9 % |
14/02/2020 |
| Federated Hermes, Inc. |
Citizenship or place of Organization |
6934600 |
0 |
6934600 |
0 |
6934600 |
12.9 % |
14/02/2020 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
6934600 |
0 |
6934600 |
6934600 |
12.9 % |
14/02/2020 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
6934600 |
0 |
6934600 |
0 |
6934600 |
12.9 % |
14/02/2020 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
6934600 |
0 |
6934600 |
6934600 |
12.9 % |
14/02/2020 |
| PRIMECAP Management Company 95-3868081 |
177 E. Colorado Blvd., 11th Floor, Pasadena, CA 91105 |
9488000 |
0 |
9488000 |
0 |
9488000 |
15 % |
10/01/2020 |
| PRIMECAP Management Company 95-3868081 |
|
9488000 |
0 |
9488000 |
0 |
9488000 |
15 % |
10/01/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
545408 |
0 |
0 |
581272 |
1.08 % |
08/11/2019 |
| Wellington Management Group LLP |
Delaware |
0 |
545408 |
0 |
0 |
581272 |
1.08 % |
08/11/2019 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
545408 |
0 |
0 |
581272 |
1.08 % |
08/11/2019 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
2764620 |
2764620 |
5.4 % |
25/06/2019 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
6750482 |
6750482 |
13.1 % |
25/06/2019 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
473006 |
473006 |
1 % |
25/06/2019 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
473006 |
473006 |
1 % |
25/06/2019 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
6750482 |
6750482 |
13.1 % |
25/06/2019 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
3288378 |
3288378 |
6.4 % |
25/06/2019 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
6750482 |
6750482 |
13.1 % |
25/06/2019 |
| Wellington Management Company LLP |
Massachusetts |
0 |
3357927 |
0 |
0 |
3475689 |
9.12 % |
12/02/2019 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3381585 |
0 |
0 |
3708658 |
9.73 % |
12/02/2019 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
3381585 |
0 |
0 |
3708658 |
9.73 % |
12/02/2019 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
3381585 |
0 |
0 |
3708658 |
9.73 % |
12/02/2019 |
| (1) BlackRock, Inc. |
Delaware |
2864115 |
0 |
3050175 |
0 |
3050175 |
8 % |
04/02/2019 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
2019000 |
2019000 |
5.6 % |
04/09/2018 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
2019000 |
2019000 |
5.6 % |
04/09/2018 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
2019000 |
2019000 |
5.6 % |
04/09/2018 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
143650 |
143650 |
1 % |
04/09/2018 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
724237 |
724237 |
2 % |
04/09/2018 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
970400 |
970400 |
2.7 % |
04/09/2018 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
143650 |
143650 |
1 % |
04/09/2018 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
724237 |
724237 |
2 % |
04/09/2018 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
2019000 |
2019000 |
5.6 % |
04/09/2018 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
143650 |
143650 |
1 % |
04/09/2018 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
2019000 |
2019000 |
5.6 % |
04/09/2018 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
970400 |
970400 |
2.7 % |
04/09/2018 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
2019000 |
2019000 |
5.6 % |
04/09/2018 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
143650 |
143650 |
1 % |
04/09/2018 |
| IX GP”) |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| Ralph E. Christoffersen (“Christoffersen”) |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| Jason Lettmann (“Lettmann”) |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| Gary R. Little (“Little”) |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| Rebecca Lynn (“Lynn”) |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| Gary J. Morgenthaler (“Morgenthaler”) |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| Robert D. Pavey (“Pavey”) |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| Henry Plain (“Plain”) |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| Robert C. Bellas, Jr. (“Bellas”) |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| IX”) |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
2811159 |
0 |
2886275 |
0 |
2886275 |
8.1 % |
01/02/2018 |
| Robert Atchinson |
United States |
0 |
3447873 |
0 |
0 |
3447873 |
9.72 % |
28/09/2017 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
3447873 |
0 |
0 |
3447873 |
9.72 % |
28/09/2017 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
3447873 |
0 |
0 |
3447873 |
9.72 % |
28/09/2017 |
| Phillip Gross |
United States |
0 |
3447873 |
0 |
0 |
3447873 |
9.72 % |
28/09/2017 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
3447873 |
0 |
0 |
3447873 |
9.72 % |
28/09/2017 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
2780800 |
0 |
0 |
3054801 |
14 % |
10/03/2017 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2780800 |
0 |
0 |
3054801 |
14 % |
10/03/2017 |
| Wellington Management Company LLP |
Massachusetts |
0 |
2780800 |
0 |
0 |
2952361 |
13.53 % |
10/03/2017 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
2780800 |
0 |
0 |
3054801 |
14 % |
10/03/2017 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2780800 |
0 |
3054801 |
3054801 |
14 % |
10/03/2017 |
| Hawkes Bay Master Investors (Cayman) L.P. |
Cayman Islands |
0 |
1094443 |
0 |
0 |
1094443 |
5.28 % |
06/03/2017 |
| David C. Ott |
Delaware |
0 |
1607936 |
0 |
1607936 |
1607936 |
7.8 % |
21/02/2017 |
| Viking Global Investors LP |
Delaware |
0 |
1607936 |
0 |
1607936 |
1607936 |
7.8 % |
21/02/2017 |
| O. Andreas Halvorsen |
Delaware |
0 |
1607936 |
0 |
1607936 |
1607936 |
7.8 % |
21/02/2017 |
| VGE III Portfolio Ltd. |
Delaware |
0 |
730880 |
0 |
730880 |
730880 |
3.5 % |
21/02/2017 |
| Viking Global Investors LP |
Delaware |
0 |
1607936 |
0 |
1607936 |
1607936 |
7.8 % |
21/02/2017 |
| Viking Global Performance LLC |
Delaware |
0 |
1142000 |
0 |
1142000 |
1142000 |
5.5 % |
21/02/2017 |
| Viking Global Equities II LP |
Delaware |
0 |
22840 |
0 |
22840 |
22840 |
0.1 % |
21/02/2017 |
| Viking Long Fund Master Ltd. |
Delaware |
0 |
465936 |
0 |
465936 |
465936 |
2.2 % |
21/02/2017 |
| Viking Global Equities LP |
Delaware |
0 |
388280 |
0 |
388280 |
388280 |
1.9 % |
21/02/2017 |
| Daniel S. Sundheim |
Delaware |
0 |
1607936 |
0 |
1607936 |
1607936 |
7.8 % |
21/02/2017 |
| David C. Ott |
Delaware |
0 |
1607936 |
0 |
1607936 |
1607936 |
7.8 % |
21/02/2017 |
| Viking Long Fund GP LLC |
Delaware |
0 |
465936 |
0 |
465936 |
465936 |
2.2 % |
21/02/2017 |
| VGE III Portfolio Ltd. |
Delaware |
0 |
730880 |
0 |
730880 |
730880 |
3.5 % |
21/02/2017 |
| Viking Global Equities II LP |
Delaware |
0 |
22840 |
0 |
22840 |
22840 |
0.1 % |
21/02/2017 |
| Viking Global Performance LLC |
Delaware |
0 |
1142000 |
0 |
1142000 |
1142000 |
5.5 % |
21/02/2017 |
| Daniel S. Sundheim |
Delaware |
0 |
1607936 |
0 |
1607936 |
1607936 |
7.8 % |
21/02/2017 |
| O. Andreas Halvorsen |
Delaware |
0 |
1607936 |
0 |
1607936 |
1607936 |
7.8 % |
21/02/2017 |
| Viking Long Fund Master Ltd. |
Delaware |
0 |
465936 |
0 |
465936 |
465936 |
2.2 % |
21/02/2017 |
| Viking Long Fund GP LLC |
Delaware |
0 |
465936 |
0 |
465936 |
465936 |
2.2 % |
21/02/2017 |
| Viking Global Equities LP |
Delaware |
0 |
388280 |
0 |
388280 |
388280 |
1.9 % |
21/02/2017 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
3635069 |
0 |
0 |
3635069 |
17.53 % |
09/02/2017 |
| Robert Atchinson |
United States |
0 |
3635069 |
0 |
0 |
3635069 |
17.53 % |
09/02/2017 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
3635069 |
0 |
0 |
3635069 |
17.53 % |
09/02/2017 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
3635069 |
0 |
0 |
3635069 |
17.53 % |
09/02/2017 |
| Phillip Gross |
United States |
0 |
3635069 |
0 |
0 |
3635069 |
17.53 % |
09/02/2017 |
| Incyte Corporation |
Delaware |
1720430 |
0 |
1720430 |
0 |
1720430 |
7.4 % |
31/01/2017 |
| Morgenthaler Venture Partners IX, L.P. (“Morgenthaler IX”) |
United States |
0 |
2161915 |
0 |
2161915 |
2161915 |
12.1 % |
17/02/2015 |
| Morgenthaler Venture Partners IX, L.P. (“Morgenthaler IX”) |
United States |
0 |
2161915 |
0 |
2161915 |
2161915 |
12.1 % |
17/02/2015 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
2141500 |
0 |
2141500 |
11.976 % |
10/11/2014 |
| FMR LLC |
Delaware |
15000 |
0 |
2141500 |
0 |
2141500 |
11.976 % |
10/11/2014 |
| Select Biotechnology Portfolio |
Delaware |
1378700 |
0 |
0 |
0 |
1378700 |
7.71 % |
10/11/2014 |
| Select Biotechnology Portfolio |
Delaware |
1378700 |
0 |
0 |
0 |
1378700 |
7.71 % |
10/11/2014 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
2141500 |
0 |
2141500 |
11.976 % |
10/11/2014 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
2141500 |
0 |
2141500 |
11.976 % |
10/11/2014 |
| FMR LLC |
Delaware |
15000 |
0 |
2141500 |
0 |
2141500 |
11.976 % |
10/11/2014 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
2141500 |
0 |
2141500 |
11.976 % |
10/11/2014 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
2765675 |
0 |
0 |
2765675 |
15.47 % |
22/10/2014 |
| Phillip Gross |
United States |
0 |
2765675 |
0 |
0 |
2765675 |
15.47 % |
22/10/2014 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
2765675 |
0 |
0 |
2765675 |
15.47 % |
22/10/2014 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
2765675 |
0 |
0 |
2765675 |
15.47 % |
22/10/2014 |
| Robert Atchinson |
United States |
0 |
2765675 |
0 |
0 |
2765675 |
15.47 % |
22/10/2014 |
| Phillip Gross |
Delaware |
0 |
2765675 |
0 |
0 |
2765675 |
15.47 % |
22/10/2014 |
| Robert Atchinson |
Delaware |
0 |
2765675 |
0 |
0 |
2765675 |
15.47 % |
22/10/2014 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
2765675 |
0 |
0 |
2765675 |
15.47 % |
22/10/2014 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
2765675 |
0 |
0 |
2765675 |
15.47 % |
22/10/2014 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
2765675 |
0 |
0 |
2765675 |
15.47 % |
22/10/2014 |