| (1) BlackRock, Inc. |
Delaware |
1740487 |
0 |
1750007 |
0 |
1750007 |
5.4 % |
12/11/2024 |
| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
1750007 |
0 |
1750007 |
5.4 % |
24/10/2024 |
| Highbridge Capital Management, LLC |
State of Delaware |
0 |
2789699 |
0 |
0 |
2789699 |
9.1 % |
07/02/2024 |
| Nippon Shinyaku Co., Ltd. |
Japan |
2145922 |
0 |
2145922 |
0 |
2145922 |
6.97 % |
17/10/2023 |
| Oracle Ten Fund, L.P. |
United States |
0 |
310616 |
0 |
310616 |
310616 |
1.52 % |
08/02/2021 |
| Oracle Partners, L.P. |
United States |
0 |
1482414 |
0 |
1482414 |
1482414 |
7.25 % |
08/02/2021 |
| Oracle Institutional Partners, L.P. |
United States |
0 |
206970 |
0 |
206970 |
206970 |
1.01 % |
08/02/2021 |
| Larry N. Feinberg |
United States |
0 |
2000000 |
0 |
2000000 |
2000000 |
9.78 % |
08/02/2021 |
| Oracle Investment Management, Inc. |
United States |
0 |
2000000 |
0 |
2000000 |
2000000 |
9.78 % |
08/02/2021 |
| Oracle Associates, LLC |
United States |
0 |
2000000 |
0 |
2000000 |
2000000 |
9.78 % |
08/02/2021 |
| Armistice Capital Master Fund Ltd. |
Delaware |
0 |
243184 |
0 |
243184 |
243184 |
4.99 % |
27/12/2019 |
| Armistice Capital, LLC |
Delaware |
0 |
243184 |
0 |
243184 |
243184 |
4.99 % |
27/12/2019 |
| Steven Boyd |
Delaware |
0 |
243184 |
0 |
243184 |
243184 |
4.99 % |
27/12/2019 |
| Cedars-Sinai Medical Center |
California |
4258292 |
0 |
4258292 |
0 |
4258292 |
18.7 % |
11/05/2017 |
| CONISTON CORPORATION |
Maryland |
638155 |
0 |
638155 |
10 |
638155 |
3.6 % |
21/03/2016 |
| LOUIS MANZO |
United States |
1178342 |
0 |
1178342 |
10 |
1178342 |
6.4 % |
21/03/2016 |
| Linda Marbán, Ph.D. |
United States |
959883 |
9200 |
959883 |
10 |
969083 |
5.2 % |
21/03/2016 |
| NANCELOU, INC. |
Maryland |
1059740 |
0 |
1059740 |
10 |
1059740 |
5.9 % |
21/03/2016 |
| LOUIS GRASMICK |
United States |
404303 |
1136755 |
404303 |
10 |
1541058 |
8.4 % |
21/03/2016 |
| NANCY GRASMICK |
United States |
0 |
1136755 |
0 |
10 |
1136755 |
6.3 % |
21/03/2016 |
| GRANT GRASMICK |
United States |
0 |
1059740 |
0 |
10 |
1059740 |
5.9 % |
21/03/2016 |
| Linda Marbán, Ph.D. |
United States |
840401 |
0 |
840401 |
10 |
840401 |
5 % |
08/05/2015 |
| GRANT GRASMICK |
United States |
0 |
1039436 |
0 |
10 |
1039436 |
6.4 % |
13/03/2015 |
| NANCY GRASMICK |
United States |
0 |
1039436 |
0 |
10 |
1039436 |
6.4 % |
13/03/2015 |
| LOUIS GRASMICK |
United States |
365648 |
1039436 |
365648 |
10 |
1405084 |
8.5 % |
13/03/2015 |
| NANCELOU, INC. |
Maryland |
1039436 |
0 |
1039436 |
10 |
1039436 |
6.4 % |
13/03/2015 |
| Frank Litvack |
United States |
1817154 |
0 |
1817154 |
10 |
1817154 |
10.1 % |
12/03/2015 |
| CONISTON CORPORATION |
Maryland |
638155 |
0 |
638155 |
0 |
638155 |
4.4 % |
26/01/2015 |
| LOUIS MANZO |
United States |
1017665 |
0 |
1017665 |
0 |
1017665 |
6.8 % |
26/01/2015 |
| BARCLAYS GLOBAL INVESTORS, NA. |
USA |
1324086 |
0 |
1324086 |
0 |
369723 |
2.65 % |
13/02/2014 |
| Joseph M. Jacobs |
United States |
0 |
52135 |
0 |
10 |
52135 |
0.45 % |
05/12/2013 |
| Iota Investors LLC |
Delaware |
0 |
38202 |
0 |
10 |
38202 |
0.33 % |
05/12/2013 |
| Wexford Spectrum Investors LLC |
Delaware |
0 |
13933 |
0 |
10 |
13933 |
0.12 % |
05/12/2013 |
| Wexford Capital LP |
Delaware |
0 |
52135 |
0 |
10 |
52135 |
0.45 % |
05/12/2013 |
| Wexford GP LLC |
Delaware |
0 |
52135 |
0 |
10 |
52135 |
0.45 % |
05/12/2013 |
| Charles E. Davidson |
United States |
0 |
52135 |
0 |
10 |
52135 |
0.45 % |
05/12/2013 |
| LOUIS GRASMICK |
United States |
301989 |
897512 |
301989 |
897512 |
1199501 |
10 % |
04/12/2013 |
| GRANT GRASMICK |
United States |
0 |
897512 |
0 |
897512 |
897512 |
7.7 % |
04/12/2013 |
| NANCELOU, INC. |
Maryland |
897512 |
0 |
897512 |
0 |
897512 |
7.7 % |
04/12/2013 |
| NANCY GRASMICK |
United States |
0 |
897512 |
0 |
897512 |
897512 |
7.7 % |
04/12/2013 |
| Eduardo Marbán, M.D., Ph.D. |
United States |
3164154 |
0 |
3164154 |
10 |
3164154 |
27.1 % |
02/12/2013 |
| Frank Litvack |
United States |
1152613 |
0 |
1152613 |
10 |
1152613 |
9 % |
02/12/2013 |
| CONISTON CORPORATION |
Maryland |
638155 |
0 |
638155 |
0 |
638155 |
5.5 % |
02/12/2013 |
| LOUIS MANZO |
United States |
301989 |
638155 |
301989 |
638155 |
940144 |
7.8 % |
02/12/2013 |
| Lynch |
California |
0 |
2111300 |
0 |
0 |
2111300 |
4.7 % |
07/08/2013 |
| Jon M. Plexico |
California |
0 |
2111300 |
0 |
0 |
2111300 |
4.7 % |
07/08/2013 |
| LLC |
California |
0 |
2111300 |
0 |
0 |
2111300 |
4.7 % |
07/08/2013 |
| L.P. |
California |
0 |
2111300 |
0 |
0 |
2111300 |
4.7 % |
07/08/2013 |
| Lynch |
California |
0 |
4123500 |
0 |
0 |
4123500 |
9.15 % |
14/02/2013 |
| L.P. |
California |
0 |
4123500 |
0 |
0 |
4123500 |
9.15 % |
14/02/2013 |
| LLC |
California |
0 |
4123500 |
0 |
0 |
4123500 |
9.15 % |
14/02/2013 |
| Jon M. Plexico |
California |
0 |
4123500 |
0 |
0 |
4123500 |
9.15 % |
14/02/2013 |
| Jon M. Plexico |
United States of America |
0 |
5400000 |
0 |
0 |
5400000 |
9.99 % |
30/06/2011 |
| Stonepine Capital Management, LLC |
California |
0 |
5400000 |
0 |
0 |
5400000 |
9.99 % |
30/06/2011 |
| Timothy P. Lynch |
United States of America |
0 |
5400000 |
0 |
0 |
5400000 |
9.99 % |
30/06/2011 |
| L.P. |
California |
0 |
5400000 |
0 |
0 |
5400000 |
9.99 % |
30/06/2011 |
| Joshua
A. Kazam |
United States of America |
1231820 |
779371 |
1231820 |
10 |
2011191 |
8.35 % |
25/09/2007 |
| Peter
M. Kash |
United States of America |
1492795 |
496589 |
1492795 |
10 |
1989384 |
8.25 % |
25/09/2007 |
| David
M. Tanen |
United States of America |
1507705 |
137941 |
1507705 |
10 |
1645646 |
6.83 % |
25/09/2007 |