| GRACE BROTHERS, LP |
PERSON WITH: |
0 |
2350152 |
0 |
2350152 |
2350152 |
3.8 % |
01/11/2023 |
| BRADFORD T. WHITMORE |
PERSON WITH: |
3914812 |
2350152 |
3914812 |
2350152 |
6264964 |
10.1 % |
01/11/2023 |
| Carmignac Gestion |
France |
3124252 |
0 |
3124252 |
0 |
3124252 |
5.2 % |
09/02/2022 |
| BRADFORD T. WHITMORE |
PERSON WITH: |
3529845 |
2348352 |
3529845 |
2348352 |
5878197 |
9.9 % |
24/01/2022 |
| GRACE BROTHERS, LP |
PERSON WITH: |
0 |
2348352 |
0 |
2348352 |
2348352 |
3.9 % |
24/01/2022 |
| Carmignac Gestion |
France |
3540961 |
0 |
3540961 |
0 |
3540961 |
7.3 % |
12/02/2021 |
| RTW
Investments, LP |
OR PLACE OF ORGANIZATION |
0 |
3958130 |
0 |
3958130 |
3958130 |
8.19 % |
12/02/2021 |
| Roderick
Wong |
OR PLACE OF ORGANIZATION |
0 |
3958130 |
0 |
3958130 |
3958130 |
8.19 % |
12/02/2021 |
| RTW
Master Fund, Ltd. |
OR PLACE OF ORGANIZATION |
0 |
2766023 |
0 |
2766023 |
2766023 |
5.72 % |
12/02/2021 |
| BRADFORD T. WHITMORE |
Delaware |
3529845 |
2835341 |
3529845 |
2835341 |
6365186 |
11 % |
07/01/2021 |
| GRACE BROTHERS, LP |
Delaware |
0 |
2835341 |
0 |
2835341 |
2835341 |
4.9 % |
07/01/2021 |
| Roderick
Wong |
Delaware |
0 |
3750107 |
0 |
3750107 |
3750107 |
9.11 % |
14/02/2020 |
| RTW
Investments, LP |
Delaware |
0 |
3750107 |
0 |
3750107 |
3750107 |
9.11 % |
14/02/2020 |
| RTW
Master Fund, Ltd. |
Delaware |
0 |
2766023 |
0 |
2766023 |
2766023 |
6.72 % |
14/02/2020 |
| Roderick
Wong |
Delaware |
0 |
3747699 |
0 |
3747699 |
3747699 |
9.93 % |
23/09/2019 |
| RTW
Investments, LP |
Delaware |
0 |
3747699 |
0 |
3747699 |
3747699 |
9.93 % |
23/09/2019 |
| RTW
Master Fund, Ltd. |
Delaware |
0 |
2867743 |
0 |
2867743 |
2867743 |
7.59 % |
23/09/2019 |
| (1) BlackRock, Inc. |
Delaware |
1781042 |
0 |
1823591 |
0 |
1823591 |
4.9 % |
10/05/2019 |
| Cormorant Asset Management, LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2019 |
| Bihua Chen |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2019 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2019 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2019 |
| Wellington Group Holdings LLP |
Delaware |
0 |
64044 |
0 |
0 |
64044 |
0.2 % |
11/02/2019 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
64044 |
0 |
0 |
64044 |
0.2 % |
11/02/2019 |
| Wellington Management Group LLP |
Massachusetts |
0 |
64044 |
0 |
0 |
64044 |
0.2 % |
11/02/2019 |
| (1) BlackRock, Inc. |
Delaware |
1860239 |
0 |
1902788 |
0 |
1902788 |
5.9 % |
07/02/2019 |
| BRO-GP, LLC |
US |
0 |
0 |
1175000 |
1175000 |
1175000 |
3.7 % |
03/01/2019 |
| GRACE BROTHERS, LP |
US |
0 |
0 |
1175000 |
1175000 |
1175000 |
3.7 % |
03/01/2019 |
| BRADFORD T. WHITMORE |
US |
2025000 |
0 |
2025000 |
1175000 |
3200000 |
10 % |
03/01/2019 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
1618751 |
0 |
0 |
1618751 |
6.4 % |
14/02/2018 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
1618751 |
0 |
0 |
1618751 |
6.4 % |
14/02/2018 |
| Bihua Chen |
United States |
0 |
1940880 |
0 |
0 |
1940880 |
7.7 % |
14/02/2018 |
| Cormorant Asset Management, LLC |
Delaware |
0 |
1940880 |
0 |
0 |
1940880 |
7.7 % |
14/02/2018 |
| (10) |
Russian Federation |
0 |
1495500 |
0 |
1495500 |
1495500 |
5.9 % |
09/02/2018 |
| (10) |
Russian Federation |
0 |
1495500 |
0 |
1495500 |
1495500 |
5.9 % |
09/02/2018 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2608255 |
0 |
0 |
2797758 |
11.04 % |
08/02/2018 |
| Wellington Management Company LLP |
Delaware |
0 |
2608255 |
0 |
0 |
2653400 |
10.47 % |
08/02/2018 |
| Wellington Group Holdings LLP |
Delaware |
0 |
2608255 |
0 |
0 |
2797758 |
11.04 % |
08/02/2018 |
| Wellington Management Group LLP |
Delaware |
0 |
2608255 |
0 |
0 |
2797758 |
11.04 % |
08/02/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2519730 |
0 |
0 |
2649264 |
10.47 % |
09/05/2017 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
2519730 |
0 |
0 |
2649264 |
10.47 % |
09/05/2017 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
2519730 |
0 |
0 |
2649264 |
10.47 % |
09/05/2017 |
| Wellington Management Company LLP |
Massachusetts |
0 |
2519730 |
0 |
0 |
2555430 |
10.1 % |
09/05/2017 |
| Cormorant Asset Management, LLC |
Delaware |
0 |
2333333 |
0 |
0 |
2333333 |
9.4 % |
14/02/2017 |
| Bihua Chen |
United States |
0 |
2333333 |
0 |
0 |
2333333 |
9.4 % |
14/02/2017 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
1945255 |
0 |
0 |
1945255 |
7.8 % |
14/02/2017 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
1945255 |
0 |
0 |
1945255 |
7.8 % |
14/02/2017 |
| Rock Springs Capital Master Fund LP |
Cayman Islands |
0 |
935000 |
0 |
0 |
935000 |
3.8 % |
14/02/2017 |
| Rock Springs Capital Management LP |
Delaware |
0 |
935000 |
0 |
0 |
935000 |
3.8 % |
14/02/2017 |
| Wellington Management Group LLP |
Delaware |
0 |
1630030 |
0 |
0 |
1644300 |
6.7 % |
09/02/2017 |
| Wellington Group Holdings LLP |
Delaware |
0 |
1630030 |
0 |
0 |
1644300 |
6.7 % |
09/02/2017 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
1630030 |
0 |
0 |
1644300 |
6.7 % |
09/02/2017 |
| Wellington Management Company LLP |
Delaware |
0 |
1630030 |
0 |
0 |
1630030 |
6.64 % |
09/02/2017 |
| 1,558,024 |
Luxembourg |
0 |
1558024 |
0 |
1558024 |
1558024 |
6.3 % |
07/02/2017 |
| 1,558,024 |
Luxembourg |
0 |
1558024 |
0 |
1558024 |
1558024 |
6.3 % |
07/02/2017 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
2070868 |
0 |
0 |
2087448 |
10.65 % |
11/07/2016 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
2070868 |
0 |
0 |
2087448 |
10.65 % |
11/07/2016 |
| Wellington Management Company LLP |
Massachusetts |
0 |
2070868 |
0 |
0 |
2070868 |
10.57 % |
11/07/2016 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2070868 |
0 |
0 |
2087448 |
10.65 % |
11/07/2016 |
| Rock Springs Capital Management LP |
Delaware |
0 |
1300000 |
0 |
0 |
1300000 |
6.6 % |
10/06/2016 |
| Rock Springs Capital Master Fund LP |
Delaware |
0 |
1300000 |
0 |
0 |
1300000 |
6.6 % |
10/06/2016 |