| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
0 |
0 |
16347383 |
15.2 % |
20/01/2023 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
184927 |
10567390 |
277399 |
10844789 |
10.23 % |
09/03/2022 |
| G. Leonard Baker, Jr. |
USA |
5465196 |
0 |
5465196 |
0 |
5465196 |
5.2 % |
14/02/2022 |
| Joseph K. Belanoff |
United States |
6374376 |
0 |
6374376 |
0 |
6374376 |
5.8 % |
11/02/2022 |
| 13-3127734 |
Delaware |
8023616 |
0 |
8023616 |
0 |
8023616 |
6.95 % |
11/02/2022 |
| 26-0385758 |
Delaware |
8023616 |
0 |
8023616 |
0 |
8023616 |
6.95 % |
11/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
14925038 |
0 |
15047993 |
0 |
15047993 |
13 % |
28/01/2022 |
| Joseph K. Belanoff |
United States |
6367964 |
0 |
6367964 |
0 |
6367964 |
5.3 % |
11/02/2021 |
| 13-3127734 |
Delaware |
9341496 |
0 |
9341496 |
0 |
9341496 |
8.04 % |
10/02/2021 |
| 26-0385758 |
Delaware |
9341496 |
0 |
9341496 |
0 |
9341496 |
8.04 % |
10/02/2021 |
| Federated Hermes, Inc. |
Citizenship or place of Organization |
5216832 |
0 |
5216832 |
0 |
5216832 |
4.55 % |
09/04/2020 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
5216832 |
0 |
5216832 |
5216832 |
4.55 % |
09/04/2020 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
5216832 |
0 |
5216832 |
0 |
5216832 |
4.55 % |
09/04/2020 |
| Thomas R. Donahue |
Citizenship or place of Organization |
0 |
5216832 |
0 |
5216832 |
5216832 |
4.55 % |
09/04/2020 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
5216832 |
0 |
5216832 |
5216832 |
4.55 % |
09/04/2020 |
| 26-0385758 |
Delaware |
7737461 |
0 |
7741516 |
26698 |
7768214 |
6.8 % |
12/02/2020 |
| 13-3127734 |
Delaware |
7737461 |
0 |
7741516 |
26698 |
7768214 |
6.8 % |
12/02/2020 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
204833 |
26700 |
10732198 |
216548 |
10948746 |
9.58 % |
12/02/2020 |
| 13-5156620 |
New York |
0 |
0 |
0 |
8285930 |
8285930 |
7.25 % |
07/02/2020 |
| 13-5156620 |
New York |
0 |
0 |
0 |
8643023 |
8643023 |
7.5 % |
30/01/2019 |
| Thomas R. Donahue |
Citizenship or place of Organization |
0 |
12624012 |
0 |
12624012 |
12624012 |
11.06 % |
14/02/2018 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
12624012 |
0 |
12624012 |
12624012 |
11.06 % |
14/02/2018 |
| Federated Investors, Inc. |
Citizenship or place of Organization |
12624012 |
0 |
12624012 |
0 |
12624012 |
11.06 % |
14/02/2018 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
12624012 |
0 |
12624012 |
12624012 |
11.06 % |
14/02/2018 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
12624012 |
0 |
12624012 |
0 |
12624012 |
11.06 % |
14/02/2018 |
| Consonance Capman GP LLC |
Delaware, USA |
0 |
5779506 |
0 |
0 |
5779506 |
5.06 % |
14/02/2018 |
| Consonance Capital Management LP |
Delaware USA |
0 |
5678244 |
0 |
0 |
5678244 |
4.98 % |
14/02/2018 |
| Consonance Capital Opportunity Fund Management LP |
Delaware USA |
0 |
101262 |
0 |
0 |
101262 |
0.09 % |
14/02/2018 |
| Mitchell Blutt |
USA |
0 |
5779506 |
0 |
0 |
5779506 |
5.06 % |
14/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
12832669 |
0 |
13049133 |
0 |
13049133 |
11.4 % |
09/02/2018 |
| 13-5156620 |
New York |
0 |
0 |
0 |
7217724 |
7217724 |
6.32 % |
08/02/2018 |
| BARCLAYS GLOBAL INVESTORS, NA. |
Pennsylvania |
178011 |
6400 |
9192168 |
178011 |
797527 |
2.7 % |
08/02/2018 |
| Juliet Tammenoms Bakker |
United States of America |
171610 |
6143547 |
171610 |
10 |
6315157 |
5.6 % |
22/03/2017 |
| Longitude Capital Associates, L.P. |
Delaware |
0 |
5836047 |
0 |
10 |
5836047 |
5.2 % |
22/03/2017 |
| Patrick G. Enright |
United States of America |
272281 |
6143547 |
272281 |
10 |
6415828 |
5.7 % |
22/03/2017 |
| Longitude Venture Partners, L.P. |
Delaware |
0 |
5836047 |
0 |
10 |
5836047 |
5.2 % |
22/03/2017 |
| Longitude Capital Partners, LLC |
Delaware |
0 |
5836047 |
0 |
10 |
5836047 |
5.2 % |
22/03/2017 |
| Longitude Capital Associates, L.P. |
Delaware |
0 |
8456002 |
0 |
10 |
8456002 |
7.6 % |
06/03/2017 |
| Longitude Venture Partners, L.P. |
Delaware |
0 |
8456002 |
0 |
10 |
8456002 |
7.6 % |
06/03/2017 |
| Juliet Tammenoms Bakker |
United States of America |
133539 |
8758502 |
133539 |
10 |
8892041 |
8 % |
06/03/2017 |
| Patrick G. Enright |
United States of America |
204210 |
8758502 |
204210 |
10 |
8962712 |
8.1 % |
06/03/2017 |
| Longitude Capital Partners, LLC |
Delaware |
0 |
8456002 |
0 |
10 |
8456002 |
7.6 % |
06/03/2017 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
13878000 |
0 |
13878000 |
13878000 |
12.5 % |
14/02/2017 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
13878000 |
0 |
13878000 |
0 |
13878000 |
12.5 % |
14/02/2017 |
| Federated Investors, Inc. |
Citizenship or place of Organization |
13878000 |
0 |
13878000 |
0 |
13878000 |
12.5 % |
14/02/2017 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
13878000 |
0 |
13878000 |
13878000 |
12.5 % |
14/02/2017 |
| John F. Donahue |
Citizenship or place of Organization |
0 |
13878000 |
0 |
13878000 |
13878000 |
12.5 % |
14/02/2017 |
| 13-5156620 |
New York |
0 |
0 |
0 |
8083697 |
8083697 |
7.3 % |
14/02/2017 |
| (1) BlackRock, Inc. |
Delaware |
5903033 |
0 |
6060804 |
0 |
6060804 |
5.5 % |
30/01/2017 |
| Longitude Venture Partners L.P. |
Delaware |
0 |
10956002 |
0 |
10 |
10956002 |
9.87 % |
15/12/2016 |
| Longitude Capital Partners, LLC |
Delaware |
0 |
10956002 |
0 |
10 |
10956002 |
9.87 % |
15/12/2016 |
| Longitude Capital Associates L.P. |
Delaware |
0 |
10956002 |
0 |
10 |
10956002 |
9.87 % |
15/12/2016 |
| Juliet Tammenoms Bakker |
United States |
204210 |
10956002 |
204210 |
10 |
11160212 |
10.05 % |
15/12/2016 |
| Patrick G. Enright |
United States |
99210 |
10956002 |
499210 |
10 |
11455212 |
10.29 % |
15/12/2016 |
| Samuel J. Pullara III |
California, USA |
41062 |
0 |
41062 |
0 |
41062 |
0 % |
16/02/2016 |
| James N. White |
California, USA |
393520 |
0 |
393520 |
0 |
393520 |
0.4 % |
16/02/2016 |
| Tench Coxe |
California, USA |
1696051 |
0 |
1696051 |
0 |
1696051 |
1.6 % |
16/02/2016 |
| G. Leonard Baker, Jr. |
California, USA |
4505527 |
0 |
4505527 |
0 |
4505527 |
4.1 % |
16/02/2016 |
| Sutter Hill Ventures, a California Limited Partnership |
California, USA |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
| Michael L. Speiser |
California, USA |
372515 |
0 |
372515 |
0 |
372515 |
0.3 % |
16/02/2016 |
| Jeffrey W. Bird |
California, USA |
381442 |
0 |
381442 |
0 |
381442 |
0.4 % |
16/02/2016 |
| Stefan A. Dyckerhoff |
California, USA |
41062 |
0 |
41062 |
0 |
41062 |
0 % |
16/02/2016 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
14189245 |
0 |
14189245 |
14189245 |
13.04 % |
11/02/2016 |
| Federated Investors, Inc. |
Citizenship or place of Organization |
14189245 |
0 |
14189245 |
0 |
14189245 |
13.04 % |
11/02/2016 |
| John F. Donahue |
Citizenship or place of Organization |
0 |
14189245 |
0 |
14189245 |
14189245 |
13.04 % |
11/02/2016 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
14189245 |
0 |
14189245 |
14189245 |
13.04 % |
11/02/2016 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
14189245 |
0 |
14189245 |
0 |
14189245 |
13.04 % |
11/02/2016 |
| 13-5156620 |
New York |
0 |
0 |
0 |
8933637 |
8933637 |
8.2 % |
09/02/2016 |
| John F. Donahue |
Citizenship or place of Organization |
0 |
14191470 |
0 |
14191470 |
14191470 |
13.89 % |
11/02/2015 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
14191470 |
0 |
14191470 |
0 |
14191470 |
13.89 % |
11/02/2015 |
| Federated Investors, Inc. |
Citizenship or place of Organization |
14191470 |
0 |
14191470 |
0 |
14191470 |
13.89 % |
11/02/2015 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
14191470 |
0 |
14191470 |
14191470 |
13.89 % |
11/02/2015 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
14191470 |
0 |
14191470 |
14191470 |
13.89 % |
11/02/2015 |
| 13-5156620 |
New York |
0 |
0 |
0 |
7772745 |
7772745 |
7.6 % |
06/02/2015 |
| J. Christopher Donahue |
Citizenship or place of Organization |
0 |
12643898 |
0 |
12643898 |
12643898 |
12.54 % |
12/02/2014 |
| Federated Investors, Inc. |
Citizenship or place of Organization |
12643898 |
0 |
12643898 |
0 |
12643898 |
12.54 % |
12/02/2014 |
| Voting Shares Irrevocable Trust |
Citizenship or place of Organization |
12643898 |
0 |
12643898 |
0 |
12643898 |
12.54 % |
12/02/2014 |
| Rhodora J. Donahue |
Citizenship or place of Organization |
0 |
12643898 |
0 |
12643898 |
12643898 |
12.54 % |
12/02/2014 |
| John F. Donahue |
Citizenship or place of Organization |
0 |
12643898 |
0 |
12643898 |
12643898 |
12.54 % |
12/02/2014 |
| 13-5156620 |
New York |
0 |
0 |
0 |
6043804 |
6043804 |
6 % |
07/02/2014 |
| M.D. |
USA |
5103805 |
0 |
5103805 |
0 |
5103805 |
5 % |
14/02/2013 |
| 13-5156620 |
New York |
0 |
0 |
0 |
5847151 |
5847151 |
5.8 % |
28/01/2013 |
| 13-5156620 |
New York |
0 |
0 |
0 |
4998552 |
4998552 |
5.9 % |
07/02/2012 |
| 13-5156620 |
New York |
0 |
0 |
0 |
4786313 |
4786313 |
5.65 % |
23/03/2011 |
| WILSON |
Number of |
3394989 |
0 |
3394989 |
0 |
3394989 |
4.7 % |
14/02/2011 |
| Alta BioPharma Partners II, L.P. |
California |
165427 |
0 |
165427 |
0 |
5385765 |
7.5 % |
07/12/2010 |
| 13-5156620 |
New York |
0 |
0 |
0 |
3560424 |
3560424 |
4.9 % |
25/08/2010 |
| 133694561 |
NEW YORK STATE |
0 |
0 |
0 |
3400000 |
3400000 |
5 % |
06/05/2010 |
| 13-5156620 |
New York |
0 |
0 |
0 |
3498313 |
3498313 |
5.2 % |
06/05/2010 |
| Michael L. Speiser |
California USA |
0 |
6028602 |
0 |
0 |
6028602 |
9.5 % |
11/02/2010 |
| William H. Younger, Jr. |
California USA |
1036519 |
6028602 |
1036519 |
0 |
7065121 |
11.2 % |
11/02/2010 |
| Tench Coxe |
California USA |
1361511 |
6028602 |
1361511 |
0 |
7390113 |
11.7 % |
11/02/2010 |
| Gregory P. Sands |
California USA |
165491 |
6028602 |
165491 |
0 |
6194093 |
9.8 % |
11/02/2010 |
| James C. Gaither |
California USA |
130234 |
6028602 |
130234 |
0 |
6158836 |
9.7 % |
11/02/2010 |
| Jeffrey W. Bird |
California USA |
143145 |
6028602 |
143145 |
0 |
6171747 |
9.8 % |
11/02/2010 |
| Sutter Hill Ventures, A California Limited Partnership 77-0287059 |
California USA |
5925216 |
0 |
5925216 |
0 |
5925216 |
9.4 % |
11/02/2010 |
| 94-3338942 |
California USA |
29273 |
0 |
29273 |
0 |
29273 |
0 % |
11/02/2010 |
| 94-3338941 |
California USA |
74113 |
0 |
74113 |
0 |
74113 |
0.1 % |
11/02/2010 |
| David L. Anderson |
California USA |
1004811 |
6028602 |
1004811 |
0 |
7033413 |
11.1 % |
11/02/2010 |
| G. Leonard Baker, Jr. |
California USA |
2981451 |
6028602 |
2981451 |
0 |
9010053 |
14.1 % |
11/02/2010 |
| James N. White |
California USA |
158962 |
6028602 |
158962 |
0 |
6187564 |
9.8 % |
11/02/2010 |
| David E. Sweet |
California USA |
56741 |
6028602 |
56741 |
0 |
6085343 |
9.6 % |
11/02/2010 |
| Andrew T. Sheehan |
California USA |
21019 |
6028602 |
21019 |
0 |
6049621 |
9.6 % |
11/02/2010 |
| David S. Congdon |
United States |
0 |
3776931 |
0 |
3776931 |
322717 |
4 % |
10/02/2010 |
| 03-0521053 |
: |
0 |
0 |
0 |
0 |
12024405 |
24.81 % |
03/04/2008 |
| 03-0521053 |
: |
0 |
0 |
0 |
0 |
8720000 |
22.04 % |
27/12/2007 |
| 03-0521053 |
: |
0 |
0 |
0 |
0 |
8285383 |
20.95 % |
01/10/2007 |
| Paperboy Ventures, LLC |
: |
0 |
0 |
0 |
7094907 |
7094907 |
18.5 % |
05/09/2007 |
| Paperboy Ventures, LLC 03-0521053 |
: |
0 |
0 |
0 |
1892527 |
1892527 |
7.35 % |
07/03/2007 |
| Allen Andersson |
: |
0 |
0 |
0 |
2392527 |
2392527 |
9.298 % |
07/03/2007 |
| JAMES N. WILSON |
Citizenship or Place of Organization |
2294154 |
0 |
2294154 |
0 |
2294154 |
8.9 % |
31/01/2007 |
| JOSEPH K. BELANOFF, M.D. |
Citizenship or Place of Organization |
2764195 |
0 |
2764195 |
0 |
2764195 |
10.7 % |
31/01/2007 |
| Joseph L. Dowling, III |
United States |
643339 |
0 |
643339 |
0 |
643339 |
2.8 % |
14/02/2006 |
| JOSEPH K. BELANOFF, M.D. |
: |
0 |
0 |
0 |
0 |
2874195 |
12.6 % |
03/02/2006 |
| ALAN SCHATZBERG |
USA |
0 |
0 |
0 |
0 |
3004346 |
13.2 % |
11/02/2005 |
| JOSEPH K. BELANOFF, M.D. |
USA |
0 |
0 |
0 |
0 |
2984195 |
13.1 % |
11/02/2005 |
| JAMES N. WILSON |
USA |
0 |
0 |
0 |
0 |
2194154 |
9.7 % |
11/02/2005 |