| (1) BlackRock, Inc. |
Delaware |
2711032 |
0 |
0 |
2711032 |
2735581 |
5.9 % |
08/11/2024 |
| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
0 |
0 |
2735581 |
5.9 % |
24/10/2024 |
| Anders Hove |
United States of America |
3043173 |
0 |
3043173 |
0 |
3043173 |
6.38 % |
26/01/2023 |
| Acorn Bioventures, L.P. |
Delaware |
3043173 |
0 |
3043173 |
0 |
3043173 |
6.38 % |
26/01/2023 |
| Acorn Capital Advisors GP, LLC |
Delaware |
3043173 |
0 |
3043173 |
0 |
3043173 |
6.38 % |
26/01/2023 |
| (1) BlackRock, Inc. |
Delaware |
671389 |
0 |
671967 |
0 |
671967 |
1.6 % |
08/07/2022 |
| Bruce S. Kovner |
Delaware |
0 |
3479340 |
0 |
3479340 |
3479340 |
8.1 % |
14/02/2022 |
| Caxton Corporation |
Delaware |
0 |
3479340 |
0 |
3479340 |
3479340 |
8.1 % |
14/02/2022 |
| CDK Associates, L.L.C. |
Delaware |
0 |
3270579 |
0 |
3270579 |
3270579 |
7.6 % |
14/02/2022 |
| Corriente Advisors, LLC |
Citizenship or place of organization |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Mark L. Hart III |
Citizenship or place of organization |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| Corriente Master Fund II, LP |
Citizenship or place of organization |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
| David Witzke |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| Avidity Master Fund LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| Michael Gregory |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| Avidity Capital Partners (GP) LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| Avidity Capital Partners Fund (GP) LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| Avidity Partners Management (GP) LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| Avidity Partners Management LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| EIN #00-0000000 |
Jersey, Channel Islands |
0 |
3523012 |
0 |
3523012 |
3523012 |
8.4 % |
10/02/2022 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
653548 |
0 |
693445 |
693445 |
1.65 % |
09/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
2493000 |
0 |
2532248 |
0 |
2532248 |
6 % |
04/02/2022 |
| PFIZER INC. |
Citizenship or Place of Organization Delaware |
2411575 |
0 |
2411575 |
0 |
2411575 |
5.75 % |
19/11/2021 |
| Bruce S. Kovner |
Delaware |
0 |
3098447 |
0 |
3098447 |
3098447 |
8.8 % |
16/02/2021 |
| CDK Associates, L.L.C. |
Delaware |
0 |
3098447 |
0 |
3098447 |
3098447 |
8.8 % |
16/02/2021 |
| Caxton Corporation |
Delaware |
0 |
3098447 |
0 |
3098447 |
3098447 |
8.8 % |
16/02/2021 |
| Mark L. Hart III |
Delaware |
0 |
2000000 |
0 |
2000000 |
2000000 |
5.66 % |
16/02/2021 |
| Corriente Master Fund II, LP |
Delaware |
0 |
2000000 |
0 |
2000000 |
2000000 |
5.66 % |
16/02/2021 |
| Corriente Advisors, LLC |
Delaware |
0 |
2000000 |
0 |
2000000 |
2000000 |
5.66 % |
16/02/2021 |
| EIN #00-0000000 |
Jersey Channel Islands |
0 |
2137671 |
0 |
2137671 |
2137671 |
6.1 % |
12/02/2021 |
| SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
2537816 |
0 |
2537816 |
2537816 |
7.18 % |
11/02/2021 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
2548772 |
0 |
2548772 |
2548772 |
7.22 % |
11/02/2021 |
| Peter Kolchinsky |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2021 |
| Rajeev Shah |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2021 |
| Avidity Master Fund LP |
Delaware |
0 |
1921759 |
0 |
1921759 |
1921759 |
5.4 % |
01/02/2021 |
| Avidity Partners Management (GP) LLC |
Delaware |
0 |
2153600 |
0 |
2153600 |
2153600 |
6.1 % |
01/02/2021 |
| Michael Gregory |
Delaware |
0 |
2153600 |
0 |
2153600 |
2153600 |
6.1 % |
01/02/2021 |
| Avidity Capital Partners Fund (GP) LP |
Delaware |
0 |
2153600 |
0 |
2153600 |
2153600 |
6.1 % |
01/02/2021 |
| Avidity Capital Partners (GP) LLC |
Delaware |
0 |
2153600 |
0 |
2153600 |
2153600 |
6.1 % |
01/02/2021 |
| Avidity Partners Management LP |
Delaware |
0 |
2153600 |
0 |
2153600 |
2153600 |
6.1 % |
01/02/2021 |
| David Witzke |
Delaware |
0 |
2153600 |
0 |
2153600 |
2153600 |
6.1 % |
01/02/2021 |
| VHCP Management III, LLC |
Delaware |
0 |
1714286 |
0 |
1714286 |
1714286 |
5.7 % |
04/11/2020 |
| Shah, Nimish |
United States |
0 |
1714286 |
0 |
1714286 |
1714286 |
5.7 % |
04/11/2020 |
| VHCP Management EG, LLC |
Delaware |
0 |
1714286 |
0 |
1714286 |
1714286 |
5.7 % |
04/11/2020 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
1714286 |
0 |
1714286 |
1714286 |
5.7 % |
04/11/2020 |
| Koh, Bong |
United States |
0 |
1714286 |
0 |
1714286 |
1714286 |
5.7 % |
04/11/2020 |
| Venrock Healthcare Capital Partners EG, L.P. |
Delaware |
0 |
1714286 |
0 |
1714286 |
1714286 |
5.7 % |
04/11/2020 |
| VHCP Co-Investment Holdings III, LLC |
Delaware |
0 |
1714286 |
0 |
1714286 |
1714286 |
5.7 % |
04/11/2020 |
| RA Capital Management, L.P. |
Delaware |
0 |
3290000 |
0 |
3290000 |
3290000 |
10.9 % |
09/10/2020 |
| 1 |
Massachusetts |
0 |
1248000 |
0 |
1248000 |
9 |
11 % |
28/08/2020 |
| Opaleye
Management Inc. |
Massachusetts |
0 |
1248000 |
0 |
1248000 |
9 |
11 % |
28/08/2020 |
| 1 |
Massachusetts |
0 |
1248000 |
0 |
1248000 |
9 |
11 % |
28/08/2020 |
| Isaac Manke |
|
5990839 |
0 |
5990839 |
11 |
5990839 |
9.9 % |
02/07/2020 |
| Acorn Capital Advisors, GP, LLC |
|
5990839 |
0 |
5990839 |
11 |
5990839 |
9.99 % |
02/07/2020 |
| Anders Hove |
|
5990839 |
0 |
5990839 |
11 |
5990839 |
9.99 % |
02/07/2020 |
| Acorn Bioventures, L.P. |
|
5990839 |
0 |
5990839 |
11 |
5990839 |
9.99 % |
02/07/2020 |
| Bruce S. Kovner |
Delaware |
0 |
1958243 |
0 |
1958243 |
1958243 |
9.9 % |
22/06/2020 |
| CDK Associates, L.L.C. |
Delaware |
0 |
1958243 |
0 |
1958243 |
1958243 |
9.9 % |
22/06/2020 |
| Caxton Corporation |
Delaware |
0 |
1958243 |
0 |
1958243 |
1958243 |
9.9 % |
22/06/2020 |
| Acorn Bioventures, L.P. |
Delaware |
1687560 |
0 |
1687560 |
0 |
1687560 |
9.99 % |
04/06/2020 |
| Armistice Capital Master Fund Ltd. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Steven Boyd |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Armistice Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Alex Noah Investors, Inc. |
Illinois |
0 |
798121 |
0 |
0 |
798121 |
9.99 % |
01/11/2019 |
| Lincoln Park Capital Fund, LLC |
Illinois |
0 |
798121 |
0 |
0 |
798121 |
9.99 % |
01/11/2019 |
| Lincoln Park Capital, LLC |
Illinois |
0 |
798121 |
0 |
0 |
798121 |
9.99 % |
01/11/2019 |
| Rockledge Capital Corporation |
Texas |
0 |
798121 |
0 |
0 |
798121 |
9.99 % |
01/11/2019 |
| Joshua B. Scheinfeld |
United States |
0 |
798121 |
0 |
0 |
798121 |
9.99 % |
01/11/2019 |
| Jonathan I. Cope |
United States |
0 |
798121 |
0 |
0 |
798121 |
9.99 % |
01/11/2019 |
| Armistice Capital Master Fund Ltd. |
Delaware |
0 |
776064 |
0 |
776064 |
776064 |
9.99 % |
01/11/2019 |
| Steven Boyd |
Delaware |
0 |
776064 |
0 |
776064 |
776064 |
9.99 % |
01/11/2019 |
| Armistice Capital, LLC |
Delaware |
0 |
776064 |
0 |
776064 |
776064 |
9.99 % |
01/11/2019 |
| District 2 Capital LP |
Austria |
0 |
0 |
0 |
250000 |
250000 |
1.1 % |
12/02/2019 |
| District 2 GP LLC |
Austria |
0 |
0 |
0 |
250000 |
250000 |
1.1 % |
12/02/2019 |
| Michael Bigger |
Austria |
0 |
0 |
0 |
1577883 |
1577883 |
6.4 % |
12/02/2019 |
| District 2 Capital Fund LP |
Austria |
0 |
0 |
0 |
250000 |
250000 |
1.1 % |
12/02/2019 |
| Bigger Capital Fund GP, LLC |
Austria |
0 |
0 |
0 |
1227833 |
1227833 |
5.1 % |
12/02/2019 |
| Bigger Capital Fund, LP |
Austria |
0 |
0 |
0 |
1227833 |
1227833 |
5.1 % |
12/02/2019 |
| District 2 Holdings LLC |
Austria |
0 |
0 |
0 |
250000 |
250000 |
1.1 % |
12/02/2019 |
| Patricia Winter |
Austria |
0 |
0 |
100000 |
0 |
100000 |
1 % |
12/02/2019 |
| District 2 Capital LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
04/09/2018 |
| Bigger Capital Fund, LP |
Delaware |
0 |
0 |
0 |
1046800 |
1046800 |
5.9 % |
04/09/2018 |
| Bigger Capital Fund GP, LLC |
Delaware |
0 |
0 |
0 |
1046800 |
1046800 |
5.9 % |
04/09/2018 |
| Michael Bigger |
Delaware |
0 |
0 |
0 |
1146800 |
1146800 |
6.5 % |
04/09/2018 |
| District 2 Capital Fund LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
04/09/2018 |
| District 2 Holdings LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
04/09/2018 |
| Patricia Winter |
Delaware |
0 |
0 |
100000 |
0 |
100000 |
1 % |
04/09/2018 |
| District 2 GP LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
04/09/2018 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
2593218 |
0 |
2593218 |
2593218 |
4.7 % |
09/02/2018 |
| Heights Capital Management, Inc. |
Delaware |
0 |
2593218 |
0 |
2593218 |
2593218 |
4.7 % |
09/02/2018 |
| Mitchell P. Kopin |
United States of America |
0 |
2666666 |
0 |
2666666 |
2666666 |
4 % |
26/12/2017 |
| Daniel B. Asher |
United States of America |
0 |
2666666 |
0 |
2666666 |
2666666 |
4 % |
26/12/2017 |
| Intracoastal Capital LLC |
United States of America |
0 |
2666666 |
0 |
2666666 |
2666666 |
4 % |
26/12/2017 |
| Heights Capital Management, Inc. |
Cayman Islands |
0 |
2124250 |
0 |
0 |
2124250 |
5.7 % |
24/07/2017 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
2124250 |
0 |
0 |
2124250 |
5.7 % |
24/07/2017 |
| BARCLAYS GLOBAL INVESTORS, NA. |
Delaware USA |
0 |
2124250 |
0 |
2124250 |
1078719 |
3.72 % |
17/07/2017 |
| (1) BlackRock, Inc. |
Delaware |
401808 |
0 |
401808 |
0 |
401808 |
1.3 % |
10/07/2017 |
| Bridger Management, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Roberto Mignone |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| (1) BlackRock, Inc. |
Delaware |
1646096 |
0 |
1683178 |
0 |
1683178 |
5.5 % |
26/01/2017 |
| Roberto Mignone |
Delaware |
0 |
2460626 |
0 |
2460626 |
2460626 |
8 % |
15/11/2016 |
| Bridger Management, LLC |
Delaware |
0 |
2460626 |
0 |
2460626 |
2460626 |
8 % |
15/11/2016 |
| Swiftcurrent Offshore, Ltd. |
Cayman Islands |
0 |
1309286 |
0 |
1309286 |
1309286 |
4.4 % |
16/02/2016 |
| Roberto Mignone |
United States |
0 |
3290587 |
0 |
3290587 |
3290587 |
11.1 % |
16/02/2016 |
| Bridger Management, LLC |
Delaware |
0 |
3290587 |
0 |
3290587 |
3290587 |
11.1 % |
16/02/2016 |
| Swiftcurrent Offshore Master, Ltd. |
Cayman Islands |
0 |
1309286 |
0 |
1309286 |
1309286 |
4.4 % |
16/02/2016 |
| (1) BlackRock, Inc. |
Delaware |
1507345 |
0 |
1546221 |
0 |
1546221 |
5.2 % |
28/01/2016 |
| Gabriele M. Cerrone |
Italy |
385378 |
1467060 |
385378 |
0 |
1852438 |
6.1 % |
31/07/2015 |
| Panetta Partners Ltd. |
Italy |
0 |
1467060 |
0 |
0 |
1467060 |
4.9 % |
31/07/2015 |
| Gabriele M. Cerrone |
Italy |
520378 |
1049026 |
520378 |
1049026 |
1569404 |
11 % |
17/02/2015 |
| Panetta Partners Ltd. |
BVI |
0 |
1049026 |
0 |
1049026 |
1049026 |
11 % |
17/02/2015 |
| Swiftcurrent Offshore, Ltd. |
Delaware |
0 |
1309286 |
0 |
1309286 |
1309286 |
6.9 % |
17/02/2015 |
| Bridger Management, LLC |
Delaware |
0 |
2587301 |
0 |
2587301 |
2587301 |
13.6 % |
17/02/2015 |
| Swiftcurrent Offshore Master, Ltd. |
Delaware |
0 |
1309286 |
0 |
1309286 |
1309286 |
6.9 % |
17/02/2015 |
| Roberto Mignone |
Delaware |
0 |
2587301 |
0 |
2587301 |
2587301 |
13.6 % |
17/02/2015 |
| Gabriele M. Cerrone |
Italy |
520378 |
1049026 |
520378 |
0 |
1569404 |
6.3 % |
13/02/2015 |
| Panetta Partners Ltd. |
Italy |
0 |
1049026 |
0 |
0 |
1049026 |
4.3 % |
13/02/2015 |
| Swiftcurrent Offshore Master, Ltd. |
Cayman Islands |
0 |
1309286 |
0 |
1309286 |
1309286 |
6.9 % |
13/01/2014 |
| Bridger Management, LLC |
Delaware |
0 |
2142857 |
0 |
2142857 |
2142857 |
11.3 % |
13/01/2014 |
| Roberto Mignone |
United States |
0 |
2142857 |
0 |
2142857 |
2142857 |
11.3 % |
13/01/2014 |
| Swiftcurrent Offshore, Ltd. |
Cayman Islands |
0 |
1309286 |
0 |
1309286 |
1309286 |
6.9 % |
13/01/2014 |
| Swiftcurrent Offshore, Ltd. |
Cayman Islands |
0 |
1309286 |
0 |
1309286 |
1309286 |
7.3 % |
09/08/2013 |
| Bridger Management, LLC |
Delaware |
0 |
2142857 |
0 |
2142857 |
2142857 |
11.9 % |
09/08/2013 |
| Roberto Mignone |
United States |
0 |
2142857 |
0 |
2142857 |
2142857 |
11.9 % |
09/08/2013 |
| R. Merrill Hunter |
USA |
8265004 |
0 |
8265004 |
0 |
8265004 |
12.2 % |
24/01/2012 |
| Gabriele M. Cerrone |
BVI |
0 |
4724852 |
0 |
4724852 |
7376757 |
10.8 % |
24/01/2012 |
| EIN:32-0056070 |
California |
0 |
171077 |
0 |
171077 |
171077 |
1.044 % |
09/02/2005 |
| Monarch Pointe Fund, Ltd. |
British Virgin Islands |
0 |
505848 |
0 |
505848 |
505848 |
3.077 % |
09/02/2005 |
| EIN: 300021359 |
California |
0 |
961539 |
0 |
961539 |
961539 |
5.81 % |
09/02/2005 |
| David F. Firestone |
USA |
0 |
961539 |
0 |
961539 |
961539 |
5.81 % |
09/02/2005 |
| EIN:03-0021366 |
California |
0 |
246154 |
0 |
246154 |
246154 |
1.501 % |
09/02/2005 |