| 52-0556948 |
Maryland |
4854723 |
0 |
0 |
0 |
4944757 |
6.2 % |
14/11/2024 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
3668085 |
0 |
0 |
4459691 |
5.57 % |
08/11/2024 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3668085 |
0 |
0 |
4459691 |
5.57 % |
08/11/2024 |
| Wellington Management Company LLP |
Massachusetts |
0 |
3644388 |
0 |
0 |
4164805 |
5.2 % |
08/11/2024 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
3668085 |
0 |
0 |
4459691 |
5.57 % |
08/11/2024 |
| EcoR1 Capital, LLC |
Delaware |
0 |
4155375 |
0 |
4155375 |
4155375 |
11 % |
11/03/2024 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
3914528 |
0 |
3914528 |
3914528 |
11 % |
11/03/2024 |
| Oleg Nodelman |
Delaware |
0 |
4155375 |
0 |
4155375 |
4155375 |
11 % |
11/03/2024 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
0 |
0 |
103623 |
3502452 |
5.24 % |
13/02/2024 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
4043865 |
0 |
4043865 |
6.053 % |
09/02/2024 |
| FMR LLC |
Delaware |
4041823 |
0 |
4043865 |
0 |
4043865 |
6.053 % |
09/02/2024 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
3420241 |
0 |
3563736 |
3563736 |
5.34 % |
24/01/2024 |
| 2 |
Delaware |
0 |
3719200 |
0 |
0 |
3719200 |
5.6 % |
18/09/2023 |
| 2 |
Delaware |
0 |
3719200 |
0 |
0 |
3719200 |
5.6 % |
18/09/2023 |
| 2 |
Delaware |
0 |
3727952 |
0 |
0 |
3727952 |
5.6 % |
18/09/2023 |
| 2 |
Delaware |
0 |
8752 |
0 |
0 |
8752 |
12 % |
18/09/2023 |
| BRIAN J. KREITER |
United States of America |
0 |
3469674 |
0 |
0 |
3469674 |
6.45 % |
14/02/2023 |
| BRAIDWELL MANAGEMENT LLC |
Delaware |
0 |
3469674 |
0 |
0 |
3469674 |
6.45 % |
14/02/2023 |
| BRAIDWELL LP |
Delaware |
0 |
3469674 |
0 |
0 |
3469674 |
6.45 % |
14/02/2023 |
| ALEXANDER T. KARNAL |
United States of America |
0 |
3469674 |
0 |
0 |
3469674 |
6.45 % |
14/02/2023 |
| Wellington Group Holdings LLP |
Delaware |
0 |
2198282 |
0 |
0 |
2804485 |
5.21 % |
06/02/2023 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2198282 |
0 |
0 |
2804485 |
5.21 % |
06/02/2023 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2198282 |
0 |
0 |
2804485 |
5.21 % |
06/02/2023 |
| Perceptive Life Sciences Master Fund, Ltd. |
|
0 |
5333532 |
0 |
5333532 |
5333532 |
10 % |
20/04/2022 |
| Joseph Edelman |
|
0 |
5333532 |
0 |
5333532 |
5333532 |
10 % |
20/04/2022 |
| Perceptive Advisors LLC |
|
0 |
5333532 |
0 |
5333532 |
5333532 |
10 % |
20/04/2022 |
| Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
1900000 |
0 |
0 |
1900000 |
4 % |
14/02/2022 |
| Deep Track Capital, LP |
Delaware |
0 |
1900000 |
0 |
0 |
1900000 |
4 % |
14/02/2022 |
| David Kroin |
United States |
0 |
1900000 |
0 |
0 |
1900000 |
4 % |
14/02/2022 |
| Vivo Capital VIII, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| OrbiMed Capital GP VI LLC |
Delaware |
0 |
2710710 |
0 |
0 |
2710710 |
5.7 % |
11/02/2022 |
| OrbiMed Advisors LLC |
Delaware |
0 |
3196876 |
0 |
0 |
3196876 |
6.7 % |
11/02/2022 |
| Versant Venture Capital V, L.P. |
|
360028 |
0 |
360028 |
0 |
360028 |
0.8 % |
10/02/2022 |
| Versant Affiliates Fund V, L.P. |
|
10841 |
0 |
10841 |
0 |
10841 |
0 % |
10/02/2022 |
| Versant Ophthalmic Affiliates Fund I, L.P. |
|
12092 |
0 |
12092 |
0 |
12092 |
0 % |
10/02/2022 |
| GP-GP |
|
0 |
27399 |
0 |
27399 |
27399 |
0.1 % |
10/02/2022 |
| Versant Ventures V (Canada), L.P. |
|
0 |
27399 |
0 |
27399 |
27399 |
0.1 % |
10/02/2022 |
| Versant Venture Capital V (Canada) LP |
|
27399 |
0 |
27399 |
0 |
27399 |
0.1 % |
10/02/2022 |
| Versant Ventures V, LLC |
|
0 |
382961 |
0 |
382961 |
382961 |
0.8 % |
10/02/2022 |
| R. Scott Struthers |
United States |
1978334 |
0 |
1978334 |
0 |
1978334 |
4.2 % |
10/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
3220862 |
0 |
3276170 |
0 |
3276170 |
6.9 % |
03/02/2022 |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
Delaware USA |
0 |
4793638 |
0 |
4793638 |
4793638 |
10.09 % |
10/01/2022 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
1166498 |
1166498 |
2.5 % |
29/10/2021 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
1600576 |
1600576 |
3.5 % |
29/10/2021 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
1600576 |
1600576 |
3.5 % |
29/10/2021 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
1166498 |
1166498 |
2.5 % |
29/10/2021 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
178655 |
178655 |
1 % |
29/10/2021 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
178655 |
178655 |
1 % |
29/10/2021 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
2767074 |
2767074 |
6 % |
29/10/2021 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
3003879 |
3003879 |
6.5 % |
29/10/2021 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
3003879 |
3003879 |
6.5 % |
29/10/2021 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
3003879 |
3003879 |
6.5 % |
29/10/2021 |
| David Kroin |
Delaware |
0 |
1898666 |
0 |
0 |
1898666 |
5.05 % |
22/04/2021 |
| Deep Track Biotechnology Master Fund, Ltd. |
Delaware |
0 |
1898666 |
0 |
0 |
1898666 |
5.05 % |
22/04/2021 |
| Deep Track Capital, LP |
Delaware |
0 |
1898666 |
0 |
0 |
1898666 |
5.05 % |
22/04/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
564102 |
0 |
0 |
564102 |
1.7 % |
16/02/2021 |
| Peter Kolchinsky |
United States |
0 |
564102 |
0 |
0 |
564102 |
1.7 % |
16/02/2021 |
| Versant Ventures V, LLC |
|
0 |
1895002 |
0 |
1895002 |
1895002 |
5.8 % |
12/02/2021 |
| Versant Venture Capital V (Canada) LP |
|
135614 |
0 |
135614 |
0 |
135614 |
0.4 % |
12/02/2021 |
| Versant Venture Capital V, L.P. |
|
1781952 |
0 |
1781952 |
0 |
1781952 |
5.4 % |
12/02/2021 |
| Versant Ophthalmic Affiliates Fund I, L.P. |
|
59437 |
0 |
59437 |
0 |
59437 |
0.2 % |
12/02/2021 |
| GP-GP |
|
0 |
135614 |
0 |
135614 |
135614 |
0.4 % |
12/02/2021 |
| Versant Ventures V (Canada), L.P. |
|
0 |
135614 |
0 |
135614 |
135614 |
0.4 % |
12/02/2021 |
| Versant Affiliates Fund V, L.P. |
|
53613 |
0 |
53613 |
0 |
53613 |
0.2 % |
12/02/2021 |
| OrbiMed Advisors LLC |
Delaware |
0 |
2753567 |
0 |
0 |
2753567 |
8.36 % |
12/02/2021 |
| OrbiMed Capital GP VI LLC |
Delaware |
0 |
2610710 |
0 |
0 |
0 |
8 % |
12/02/2021 |
| Vivo Opportunity, LLC |
|
461575 |
0 |
461575 |
0 |
461575 |
1.4 % |
12/02/2021 |
| Vivo Capital LLC |
|
54711 |
0 |
54711 |
0 |
54711 |
0.2 % |
12/02/2021 |
| Vivo Capital VIII, LLC |
|
1819600 |
0 |
1819600 |
0 |
1819600 |
5.5 % |
12/02/2021 |
| R. Scott Struthers |
United States |
1703995 |
0 |
1703995 |
0 |
1703995 |
5.1 % |
05/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
2084827 |
0 |
2113195 |
0 |
2113195 |
6.4 % |
02/02/2021 |
| Vivo
Capital VIII, LLC |
Delaware |
2244904 |
0 |
2244904 |
0 |
2244904 |
6.8 % |
11/06/2020 |
| Vivo
Opportunity, LLC |
Delaware |
168165 |
0 |
168165 |
0 |
168165 |
0.5 % |
11/06/2020 |
| Vivo
Capital LLC |
Delaware |
54711 |
0 |
54711 |
0 |
54711 |
0.2 % |
11/06/2020 |
| Perceptive Advisors LLC |
|
0 |
3659381 |
0 |
11 |
3659381 |
11.6 % |
20/04/2020 |
| Ltd. |
|
0 |
3659381 |
0 |
11 |
3659381 |
11.6 % |
20/04/2020 |
| Joseph Edelman |
|
0 |
3659381 |
0 |
11 |
3659381 |
11.6 % |
20/04/2020 |
| OrbiMed Advisors LLC |
Delaware |
0 |
2039282 |
0 |
0 |
2039282 |
8.42 % |
14/02/2020 |
| Capital GP VI LLC |
Delaware |
0 |
2039282 |
0 |
0 |
2039282 |
8.42 % |
14/02/2020 |
| Vivo
Capital VIII, LLC |
OR PLACE OF ORGANIZATION |
3098320 |
0 |
3098320 |
0 |
3098320 |
12.8 % |
13/02/2020 |
| Vivo
Capital LLC |
OR PLACE OF ORGANIZATION |
54711 |
0 |
54711 |
0 |
54711 |
0.2 % |
13/02/2020 |
| Vivo
Opportunity, LLC |
OR PLACE OF ORGANIZATION |
168298 |
0 |
168298 |
0 |
168298 |
0.7 % |
13/02/2020 |
| R. Scott Struthers |
United States |
1503154 |
0 |
1503154 |
0 |
1503154 |
6.1 % |
11/02/2020 |
| Peter Kolchinsky |
Citizenship or Place of Organization United States |
0 |
1875209 |
0 |
1875209 |
1875209 |
7.8 % |
14/02/2019 |
| RA Capital Management, LLC |
Citizenship or Place of Organization Massachusetts |
0 |
1875209 |
0 |
1875209 |
1875209 |
7.8 % |
14/02/2019 |
| 5AM Ventures IV, L.P. |
Delaware, United States of America |
0 |
3359309 |
0 |
3359309 |
3359309 |
14.6 % |
30/07/2018 |
| Vivo
Opportunity, LLC |
Delaware |
294357 |
0 |
294357 |
0 |
294357 |
1.2 % |
26/07/2018 |
| Vivo
Capital LLC |
Delaware |
54711 |
0 |
54711 |
0 |
54711 |
0.2 % |
26/07/2018 |
| Vivo
Capital VIII, LLC |
Delaware |
3443101 |
0 |
3443101 |
0 |
3443101 |
14.4 % |
26/07/2018 |