Armistice Capital, LLC |
Delaware |
0 |
8200000 |
0 |
8200000 |
0 |
5.13 % |
14/11/2024 |
Steven Boyd |
United States of America |
0 |
8200000 |
0 |
8200000 |
0 |
5.13 % |
14/11/2024 |
The Vanguard Group |
Pennsylvania |
0 |
333123 |
21550638 |
487459 |
22038097 |
13.79 % |
12/11/2024 |
BlackRock, Inc. |
Delaware |
22687042 |
0 |
22918324 |
0 |
22918324 |
14.3 % |
08/11/2024 |
BlackRock, Inc. |
Delaware |
0 |
0 |
22918324 |
0 |
22918324 |
14.3 % |
23/10/2024 |
STATE STREET CORPORATION |
MA |
0 |
9417474 |
0 |
9919865 |
9919865 |
6.2 % |
16/10/2024 |
LSV Asset Management |
State of Delaware |
4449270 |
0 |
6793701 |
0 |
6793701 |
4.35 % |
09/02/2024 |
LSV Asset Management |
State of Delaware |
4449270 |
0 |
6793701 |
0 |
6793701 |
4.35 % |
09/02/2024 |
SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
8456559 |
0 |
8483913 |
8483913 |
5.43 % |
25/01/2024 |
STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
11117328 |
0 |
11532088 |
11532088 |
7.39 % |
25/01/2024 |
BlackRock, Inc. |
Delaware |
25253721 |
0 |
25978899 |
0 |
25978899 |
16.6 % |
22/01/2024 |
The Vanguard Group |
Pennsylvania |
0 |
163827 |
15711058 |
322487 |
16033545 |
10.27 % |
10/01/2024 |
The Vanguard Group |
Pennsylvania |
0 |
163827 |
15711058 |
322487 |
16033545 |
10.27 % |
10/01/2024 |
Westfield Capital Management Company, LP |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
05/07/2023 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/05/2023 |
Wellington Management Group LLP |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
10/05/2023 |
Wellington Group Holdings LLP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/05/2023 |
The Vanguard Group |
Pennsylvania For |
0 |
228594 |
14366224 |
366345 |
14732569 |
9.6 % |
09/02/2023 |
SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
8504884 |
0 |
8532238 |
8532238 |
5.56 % |
02/02/2023 |
STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
10849469 |
0 |
11179578 |
11179578 |
7.29 % |
02/02/2023 |
BlackRock, Inc. |
Delaware |
25217771 |
0 |
25771192 |
0 |
25771192 |
16.8 % |
26/01/2023 |
BlackRock, Inc. |
Delaware |
0 |
0 |
0 |
0 |
25771192 |
16.8 % |
20/01/2023 |
BlackRock, Inc. |
Delaware |
26375963 |
0 |
26895087 |
0 |
26895087 |
17.5 % |
08/07/2022 |
Brown Capital Management, LLC |
State of Maryland |
11453039 |
0 |
16257899 |
0 |
16257899 |
9.93 % |
14/02/2022 |
The Brown Capital Management Small Company Fund |
State of Delaware |
9980218 |
0 |
9980218 |
0 |
9980218 |
6.1 % |
14/02/2022 |
Brown Capital Management, LLC |
State of Maryland |
11453039 |
0 |
16257899 |
0 |
16257899 |
9.93 % |
14/02/2022 |
The Brown Capital Management Small Company Fund |
State of Delaware |
9980218 |
0 |
9980218 |
0 |
9980218 |
6.1 % |
14/02/2022 |
The Vanguard Group |
Pennsylvania For |
0 |
291675 |
13058180 |
429582 |
13487762 |
8.24 % |
10/02/2022 |
Wellington Management Group LLP |
Massachusetts |
0 |
15826094 |
0 |
17339587 |
17339587 |
10.59 % |
04/02/2022 |
Wellington Management Company LLP |
Delaware |
0 |
15265619 |
0 |
15280091 |
15280091 |
9.33 % |
04/02/2022 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
15826094 |
0 |
17339587 |
17339587 |
10.59 % |
04/02/2022 |
Wellington Group Holdings LLP |
Delaware |
0 |
15826094 |
0 |
17339587 |
17339587 |
10.59 % |
04/02/2022 |
Wellington Management Company LLP |
Delaware |
0 |
15265619 |
0 |
15280091 |
15280091 |
9.33 % |
04/02/2022 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
15826094 |
0 |
17339587 |
17339587 |
10.59 % |
04/02/2022 |
Wellington Group Holdings LLP |
Delaware |
0 |
15826094 |
0 |
17339587 |
17339587 |
10.59 % |
04/02/2022 |
Wellington Management Group LLP |
Massachusetts |
0 |
15826094 |
0 |
17339587 |
17339587 |
10.59 % |
04/02/2022 |
BlackRock, Inc. |
Delaware |
13827975 |
0 |
14368890 |
0 |
14368890 |
8.8 % |
02/02/2022 |
Westfield Capital Management Company, LP |
Massachusetts |
7387904 |
0 |
8145674 |
0 |
8145674 |
4.98 % |
01/02/2022 |
The Vanguard Group |
Pennsylvania |
0 |
373344 |
15368035 |
524312 |
15892347 |
9.93 % |
10/02/2021 |
Wellington Management Group LLP |
Massachusetts |
0 |
20061000 |
0 |
21653549 |
21653549 |
13.53 % |
04/02/2021 |
Wellington Management Company LLP |
Delaware |
0 |
19476837 |
0 |
19509866 |
19509866 |
12.19 % |
04/02/2021 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
20061000 |
0 |
21653549 |
21653549 |
13.53 % |
04/02/2021 |
Wellington Group Holdings LLP |
Delaware |
0 |
20061000 |
0 |
21653549 |
21653549 |
13.53 % |
04/02/2021 |
Wellington Management Group LLP |
Massachusetts |
0 |
20061000 |
0 |
21653549 |
21653549 |
13.53 % |
04/02/2021 |
Wellington Management Company LLP |
Delaware |
0 |
19476837 |
0 |
19509866 |
19509866 |
12.19 % |
04/02/2021 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
20061000 |
0 |
21653549 |
21653549 |
13.53 % |
04/02/2021 |
Wellington Group Holdings LLP |
Delaware |
0 |
20061000 |
0 |
21653549 |
21653549 |
13.53 % |
04/02/2021 |
BlackRock, Inc. |
Delaware |
12844041 |
0 |
13044650 |
0 |
13044650 |
8.1 % |
29/01/2021 |
Westfield Capital Management Company, LP |
Massachusetts |
7660852 |
0 |
8488042 |
0 |
8488042 |
5.3 % |
06/01/2021 |
Westfield Capital Management Company, LP |
Massachusetts |
7660852 |
0 |
8488042 |
0 |
8488042 |
5.3 % |
06/01/2021 |
FMR LLC |
Delaware |
1069474 |
0 |
2807589 |
0 |
2807589 |
1.748 % |
10/11/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2807589 |
0 |
2807589 |
1.748 % |
10/11/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2807589 |
0 |
2807589 |
1.748 % |
10/11/2020 |
FMR LLC |
Delaware |
1069474 |
0 |
2807589 |
0 |
2807589 |
1.748 % |
10/11/2020 |
Brown Capital Management Small Company Fund |
|
|
|
|
|
9980218 |
6.36 % |
14/02/2020 |
Capital Management, LLC |
|
|
|
|
|
17901053 |
11.42 % |
14/02/2020 |
The Vanguard Group |
Pennsylvania |
322642 |
24865 |
16309201 |
329740 |
16638941 |
10.61 % |
11/02/2020 |
The Vanguard Group |
Pennsylvania |
322642 |
24865 |
16309201 |
329740 |
16638941 |
10.61 % |
11/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
11353494 |
0 |
11353494 |
7.214 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
11353494 |
0 |
11353494 |
7.214 % |
07/02/2020 |
FMR LLC |
Delaware |
2874977 |
0 |
11353494 |
0 |
11353494 |
7.214 % |
07/02/2020 |
FMR LLC |
Delaware |
2874977 |
0 |
11353494 |
0 |
11353494 |
7.214 % |
07/02/2020 |
Wellington Management Group LLP |
Massachusetts |
0 |
20301618 |
0 |
21777701 |
21777701 |
13.89 % |
28/01/2020 |
Wellington Management Company LLP |
Delaware |
0 |
19717128 |
0 |
19751144 |
19751144 |
12.59 % |
28/01/2020 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
20301618 |
0 |
21777701 |
21777701 |
13.89 % |
28/01/2020 |
Wellington Group Holdings LLP |
Delaware |
0 |
20301618 |
0 |
21777701 |
21777701 |
13.89 % |
28/01/2020 |
Wellington Management Group LLP |
Massachusetts |
0 |
20301618 |
0 |
21777701 |
21777701 |
13.89 % |
28/01/2020 |
Wellington Management Company LLP |
Delaware |
0 |
19717128 |
0 |
19751144 |
19751144 |
12.59 % |
28/01/2020 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
20301618 |
0 |
21777701 |
21777701 |
13.89 % |
28/01/2020 |
Wellington Group Holdings LLP |
Delaware |
0 |
20301618 |
0 |
21777701 |
21777701 |
13.89 % |
28/01/2020 |
Brown Capital Management, LLC |
State of Maryland |
11317045 |
0 |
17160781 |
0 |
17160781 |
10.97 % |
09/09/2019 |
The Brown Capital Management Small Company Fund |
State of Delaware |
9282457 |
0 |
9282457 |
0 |
9282457 |
5.93 % |
09/09/2019 |
Brown Capital Management, LLC |
State of Maryland |
11317045 |
0 |
17160781 |
0 |
17160781 |
10.97 % |
09/09/2019 |
The Brown Capital Management Small Company Fund |
State of Delaware |
9282457 |
0 |
9282457 |
0 |
9282457 |
5.93 % |
09/09/2019 |
The Vanguard Group |
Pennsylvania |
298537 |
19406 |
15347559 |
300176 |
15647735 |
10.05 % |
10/06/2019 |
The Vanguard Group |
Pennsylvania |
298537 |
19406 |
15347559 |
300176 |
15647735 |
10.05 % |
10/06/2019 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
966384 |
0 |
4112779 |
0 |
4112779 |
2.9 % |
14/02/2019 |
The Vanguard Group |
Pennsylvania |
291521 |
19406 |
13063404 |
297150 |
13360554 |
9.53 % |
13/02/2019 |
BlackRock, Inc. |
Delaware |
11874500 |
0 |
12317565 |
0 |
12317565 |
8.8 % |
04/02/2019 |
Brown Capital Management, LLC |
State of Maryland |
4702104 |
0 |
7517834 |
0 |
7517834 |
5.37 % |
10/12/2018 |
Brown Capital Management, LLC |
State of Maryland |
4702104 |
0 |
7517834 |
0 |
7517834 |
5.37 % |
10/12/2018 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
2156457 |
0 |
12207015 |
0 |
12207015 |
8.7 % |
10/07/2018 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
3057280 |
0 |
18924414 |
0 |
18924414 |
13.8 % |
14/02/2018 |
The Vanguard Group |
Pennsylvania |
262988 |
19406 |
11003173 |
271617 |
11274790 |
8.32 % |
09/02/2018 |
Wellington Management Company LLP |
Delaware |
0 |
11304317 |
0 |
17776619 |
17776619 |
13.13 % |
08/02/2018 |
Wellington Group Holdings LLP |
Delaware |
0 |
11740665 |
0 |
18957167 |
18957167 |
14 % |
08/02/2018 |
Wellington Management Group LLP |
Massachusetts |
0 |
11740665 |
0 |
18957167 |
18957167 |
14 % |
08/02/2018 |
Wellington Management Company LLP |
Delaware |
0 |
11304317 |
0 |
17776619 |
17776619 |
13.13 % |
08/02/2018 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
11740665 |
0 |
18957167 |
18957167 |
14 % |
08/02/2018 |
Wellington Group Holdings LLP |
Delaware |
0 |
11740665 |
0 |
18957167 |
18957167 |
14 % |
08/02/2018 |
Wellington Management Group LLP |
Massachusetts |
0 |
11740665 |
0 |
18957167 |
18957167 |
14 % |
08/02/2018 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
11740665 |
0 |
18957167 |
18957167 |
14 % |
08/02/2018 |
BlackRock, Inc. |
Delaware |
11393916 |
0 |
11702048 |
0 |
11702048 |
8.6 % |
25/01/2018 |
Steven A. Cohen |
United States |
0 |
1124451 |
0 |
1124451 |
1124451 |
0.9 % |
14/02/2017 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
7919 |
0 |
7919 |
7919 |
0.1 % |
14/02/2017 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
1116532 |
0 |
1116532 |
1116532 |
0.9 % |
14/02/2017 |
Point72 Asset Management, L.P. |
Delaware |
0 |
1116532 |
0 |
1116532 |
1116532 |
0.9 % |
14/02/2017 |
Samuel D. Isaly |
United States |
0 |
7241300 |
0 |
7241300 |
7241300 |
4.95 % |
13/02/2017 |
OrbiMed Capital LLC |
Delaware |
0 |
4717300 |
0 |
0 |
4717300 |
3.23 % |
13/02/2017 |
OrbiMed Advisors LLC |
Delaware |
0 |
2524000 |
0 |
2524000 |
2524000 |
1.73 % |
13/02/2017 |
The Vanguard Group |
Pennsylvania |
257363 |
17206 |
9675090 |
268192 |
9943282 |
7.58 % |
10/02/2017 |
Wellington Management Group LLP |
Massachusetts |
0 |
11535619 |
0 |
18363862 |
18363862 |
14 % |
09/02/2017 |
Wellington Group Holdings LLP |
Delaware |
0 |
11535619 |
0 |
18363862 |
18363862 |
14 % |
09/02/2017 |
Wellington Management Company LLP |
Delaware |
0 |
11107398 |
0 |
17454405 |
17454405 |
13.31 % |
09/02/2017 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
11535619 |
0 |
18363862 |
18363862 |
14 % |
09/02/2017 |
T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
15529367 |
11.7 % |
10/01/2017 |
T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
15529367 |
11.7 % |
10/01/2017 |
Janus Capital Management LLC EIN #753019302 |
Delaware |
15761477 |
0 |
15761477 |
0 |
15761477 |
12.4 % |
16/02/2016 |
Samuel D. Isaly |
United States |
0 |
11226400 |
0 |
11226400 |
11226400 |
8.84 % |
16/02/2016 |
Samuel D. Isaly |
United States |
0 |
11226400 |
0 |
11226400 |
11226400 |
8.84 % |
16/02/2016 |
OrbiMed Advisors LLC |
Delaware |
0 |
4509500 |
0 |
4509500 |
4509500 |
3.55 % |
16/02/2016 |
OrbiMed Capital LLC |
Delaware |
0 |
6716900 |
0 |
0 |
6716900 |
5.29 % |
16/02/2016 |
OrbiMed Advisors LLC |
Delaware |
0 |
4509500 |
0 |
4509500 |
4509500 |
3.55 % |
16/02/2016 |
OrbiMed Capital LLC |
Delaware |
0 |
6716900 |
0 |
0 |
6716900 |
5.29 % |
16/02/2016 |
BlackRock, Inc. |
Delaware |
9167345 |
0 |
9444903 |
0 |
9444903 |
7.4 % |
10/02/2016 |
The Vanguard Group |
Pennsylvania |
280205 |
10200 |
8528218 |
282605 |
8810823 |
6.93 % |
10/02/2016 |
Morgan Stanley |
The state of organization is Delaware. |
982891 |
0 |
0 |
990091 |
990091 |
0.8 % |
10/09/2015 |
Morgan Stanley Investment Management Inc. |
The state of organization is Delaware. |
990091 |
0 |
0 |
982891 |
982891 |
0.8 % |
10/09/2015 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
2005800 |
0 |
2005800 |
2005800 |
1.6 % |
20/08/2015 |
Point72 Asset Management, L.P. |
Delaware |
0 |
2005800 |
0 |
2005800 |
2005800 |
1.6 % |
20/08/2015 |
Rubric Capital Management, LLC |
Delaware |
0 |
3874376 |
0 |
3874376 |
3874376 |
3.1 % |
20/08/2015 |
EverPoint Asset Management, LLC |
Delaware |
0 |
500000 |
0 |
500000 |
500000 |
0.4 % |
20/08/2015 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
4974 |
0 |
4974 |
4974 |
0.1 % |
20/08/2015 |
Rubric Capital Management, LLC |
Delaware |
0 |
3874376 |
0 |
3874376 |
3874376 |
3.1 % |
20/08/2015 |
Steven A. Cohen |
United States |
0 |
6385150 |
0 |
6385150 |
6385150 |
5 % |
20/08/2015 |
EverPoint Asset Management, LLC |
Delaware |
0 |
500000 |
0 |
500000 |
500000 |
0.4 % |
20/08/2015 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
4974 |
0 |
4974 |
4974 |
0.1 % |
20/08/2015 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
2005800 |
0 |
2005800 |
2005800 |
1.6 % |
20/08/2015 |
Point72 Asset Management, L.P. |
Delaware |
0 |
2005800 |
0 |
2005800 |
2005800 |
1.6 % |
20/08/2015 |
Steven A. Cohen |
United States |
0 |
6385150 |
0 |
6385150 |
6385150 |
5 % |
20/08/2015 |
Janus Capital Management LLC EIN #753019302 |
Delaware |
14286607 |
0 |
14286607 |
0 |
14286607 |
11.6 % |
17/02/2015 |
VR Management, LLC |
Delaware |
0 |
21051692 |
0 |
21051692 |
21051692 |
1.7 % |
17/02/2015 |
VHCP CoInvestment Holdings, LLC |
Delaware |
0 |
189102 |
0 |
189102 |
189102 |
0 % |
17/02/2015 |
Venrock Management, LLC |
Delaware |
0 |
21051692 |
0 |
21051692 |
21051692 |
1.7 % |
17/02/2015 |
Venrock Partners V, L.P. |
Delaware |
0 |
21051692 |
0 |
21051692 |
21051692 |
1.7 % |
17/02/2015 |
VHCP Management, LLC |
Delaware |
0 |
189102 |
0 |
189102 |
189102 |
0 % |
17/02/2015 |
Venrock Associates II, L.P. |
New York |
0 |
21051692 |
0 |
21051692 |
21051692 |
1.7 % |
17/02/2015 |
Venrock Entrepreneurs Fund, L.P. |
New York |
0 |
21051692 |
0 |
21051692 |
21051692 |
1.7 % |
17/02/2015 |
Venrock Associates V, L.P. |
Delaware |
0 |
21051692 |
0 |
21051692 |
21051692 |
1.7 % |
17/02/2015 |
Venrock Associates |
New York |
0 |
21051692 |
0 |
21051692 |
21051692 |
1.7 % |
17/02/2015 |
Venrock Healthcare Capital Partners, L.P. |
Delaware |
0 |
189102 |
0 |
189102 |
189102 |
0 % |
17/02/2015 |
Venrock Partners Management V, LLC |
Delaware |
0 |
21051692 |
0 |
21051692 |
21051692 |
1.7 % |
17/02/2015 |
Venrock Management V, LLC |
Delaware |
0 |
21051692 |
0 |
21051692 |
21051692 |
1.7 % |
17/02/2015 |
BVF Partners L.P. |
Delaware |
0 |
5093810 |
0 |
5093810 |
5093810 |
4.1 % |
17/02/2015 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
BVF Investments, L.L.C. |
Delaware |
0 |
5093810 |
0 |
5093810 |
5093810 |
4.1 % |
17/02/2015 |
Mark N. Lampert |
United States |
0 |
5093810 |
0 |
5093810 |
5093810 |
4.1 % |
17/02/2015 |
Investment 10, L.L.C. |
Illinois |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
BVF Inc. |
Delaware |
0 |
5093810 |
0 |
5093810 |
5093810 |
4.1 % |
17/02/2015 |
OrbiMed Advisors LLC |
Delaware |
0 |
4781300 |
0 |
4781300 |
4781300 |
3.87 % |
17/02/2015 |
OrbiMed Capital LLC |
Delaware |
0 |
7230800 |
0 |
0 |
7230800 |
5.85 % |
17/02/2015 |
Samuel D. Isaly |
United States |
0 |
12012100 |
0 |
12012100 |
12012100 |
9.71 % |
17/02/2015 |
Sectoral Asset Management Inc. |
Canada |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2015 |
Jérôme G. Pfund |
Swiss |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2015 |
Michael L. Sjöström |
Swiss |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2015 |
The Vanguard Group |
Pennsylvania |
160644 |
|
7393703 |
150044 |
7543747 |
6.09 % |
10/02/2015 |
Janus Capital Management LLC EIN |
Delaware |
12366704 |
0 |
12366704 |
0 |
12366704 |
10.2 % |
10/09/2014 |
Janus Capital Management LLC EIN |
Delaware |
12366704 |
0 |
12366704 |
0 |
12366704 |
10.2 % |
10/09/2014 |
Wellington Management Company, LLP |
Massachusetts |
0 |
8335008 |
0 |
13625326 |
13625326 |
13.98 % |
14/02/2014 |
FMR LLC |
Delaware |
890036 |
0 |
15717418 |
0 |
15717418 |
16.124 % |
14/02/2014 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
15717418 |
0 |
15717418 |
16.124 % |
14/02/2014 |
Michael L. Sjöström |
Swiss |
3943762 |
0 |
5084999 |
0 |
5084999 |
5.2 % |
11/02/2014 |
Jérôme G. Pfund |
Swiss |
3943762 |
0 |
5084999 |
0 |
5084999 |
5.2 % |
11/02/2014 |
Sectoral Asset Management Inc. |
Canada |
3943762 |
0 |
5084999 |
0 |
5084999 |
5.2 % |
11/02/2014 |
Morgan Stanley Investment Management Inc. #133040307 |
organization is Delaware |
8159649 |
0 |
8254925 |
0 |
8254925 |
6.8 % |
11/02/2014 |
Morgan Stanley #363145972 |
organization is Delaware |
8159649 |
0 |
8254925 |
0 |
8254925 |
6.8 % |
11/02/2014 |
The Vanguard Group |
Pennsylvania |
136208 |
|
5537367 |
130408 |
5667775 |
5.81 % |
11/02/2014 |
BlackRock, Inc. |
Delaware |
7126353 |
0 |
7423981 |
0 |
7423981 |
7.6 % |
29/01/2014 |
State of Wisconsin Investment Board ____________________________________________________________________________ |
Madison, Wisconsin |
|
|
6163095 |
|
6163095 |
6.323 % |
29/01/2014 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
15517318 |
0 |
15517318 |
16.697 % |
10/06/2013 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
15517318 |
0 |
15517318 |
16.697 % |
10/06/2013 |
FMR LLC |
Delaware |
837736 |
0 |
15517318 |
0 |
15517318 |
16.697 % |
10/06/2013 |
FMR LLC |
Delaware |
837736 |
0 |
15517318 |
0 |
15517318 |
16.697 % |
10/06/2013 |
BVF Partners L.P. |
Delaware |
0 |
5287127 |
0 |
5287127 |
5287127 |
6.9 % |
14/02/2013 |
BVF Inc. |
Delaware |
0 |
5287127 |
0 |
5287127 |
5287127 |
6.9 % |
14/02/2013 |
Mark N. Lampert |
United States |
0 |
5287127 |
0 |
5287127 |
5287127 |
6.9 % |
14/02/2013 |
BVF Investments, L.L.C. |
Delaware |
0 |
5252561 |
0 |
5252561 |
5252561 |
6.9 % |
14/02/2013 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
14377 |
0 |
14377 |
14377 |
0 % |
14/02/2013 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
20189 |
0 |
20189 |
20189 |
0 % |
14/02/2013 |
The Vanguard Group |
Pennsylvania |
111341 |
|
4105839 |
107441 |
4213280 |
5.5 % |
13/02/2013 |
BlackRock, Inc. |
Delaware |
4928821 |
0 |
4928821 |
0 |
4928821 |
6.51 % |
30/01/2013 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
20189 |
0 |
20189 |
20189 |
0 % |
05/11/2012 |
BVF Inc. |
Delaware |
0 |
4117827 |
0 |
4117827 |
4117827 |
5.4 % |
05/11/2012 |
Mark N. Lampert |
United States |
0 |
4117827 |
0 |
4117827 |
4117827 |
5.4 % |
05/11/2012 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
14377 |
0 |
14377 |
14377 |
0 % |
05/11/2012 |
BVF Investments, L.L.C. |
Delaware |
0 |
4083261 |
0 |
4083261 |
4083261 |
5.4 % |
05/11/2012 |
BVF Partners L.P. |
Delaware |
0 |
4117827 |
0 |
4117827 |
4117827 |
5.4 % |
05/11/2012 |
Wellington Management Company, LLP |
Massachusetts |
0 |
2816830 |
0 |
5111940 |
5111940 |
10.52 % |
10/05/2011 |
Wellington Management Company, LLP |
Massachusetts |
0 |
2816830 |
0 |
5111940 |
5111940 |
10.52 % |
10/05/2011 |
Ridgeback Capital Management LP |
Delaware |
0 |
10389262 |
0 |
10389262 |
10389262 |
18.2 % |
15/02/2011 |
Ridgeback Capital Management LP |
Delaware |
0 |
10389262 |
0 |
10389262 |
10389262 |
18.2 % |
15/02/2011 |
Ridgeback Capital Investments Ltd. |
Cayman Islands |
0 |
10389262 |
0 |
10389262 |
10389262 |
18.2 % |
15/02/2011 |
Ridgeback Capital Investments L.P. |
Cayman Islands |
0 |
10389262 |
0 |
10389262 |
10389262 |
18.2 % |
15/02/2011 |
Ridgeback Capital Investments L.P. |
Cayman Islands |
0 |
10389262 |
0 |
10389262 |
10389262 |
18.2 % |
15/02/2011 |
Ridgeback Capital Investments Ltd. |
Cayman Islands |
0 |
10389262 |
0 |
10389262 |
10389262 |
18.2 % |
15/02/2011 |
S Adage Capital Partners, L.P. |
Delaware |
0 |
2381305 |
0 |
2381305 |
2381305 |
5.11 % |
14/02/2011 |
S Phillip Gross |
United States |
0 |
2381305 |
0 |
2381305 |
2381305 |
5.11 % |
14/02/2011 |
S Robert Atchinson |
United States |
0 |
2381305 |
0 |
2381305 |
2381305 |
5.11 % |
14/02/2011 |
S Adage Capital Advisors, L.L.C. |
Delaware |
0 |
2381305 |
0 |
2381305 |
2381305 |
5.11 % |
14/02/2011 |
S Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
2381305 |
0 |
2381305 |
2381305 |
5.11 % |
14/02/2011 |
NOS. OF ABOVE PERSON Bridger Management, LLC |
Delaware |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.4 % |
14/02/2011 |
NOS. OF ABOVE PERSON Roberto Mignone |
United States |
0 |
2500000 |
0 |
2500000 |
2500000 |
5.4 % |
14/02/2011 |
SS OR |
USA |
6303980 |
6303980 |
6303980 |
6303980 |
6303980 |
12 % |
11/02/2011 |
Bridger Management, LLC |
Delaware |
0 |
2390679 |
0 |
2390679 |
2390679 |
5.1 % |
20/12/2010 |
Bridger Management, LLC |
Delaware |
0 |
2390679 |
0 |
2390679 |
2390679 |
5.1 % |
20/12/2010 |
Roberto Mignone |
United States |
0 |
2390679 |
0 |
2390679 |
2390679 |
5.1 % |
20/12/2010 |
Roberto Mignone |
United States |
0 |
2390679 |
0 |
2390679 |
2390679 |
5.1 % |
20/12/2010 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
4062638 |
0 |
4062638 |
10.008 % |
12/10/2010 |
FMR LLC |
Delaware |
3712038 |
0 |
4062638 |
0 |
4062638 |
10.008 % |
12/10/2010 |
FMR LLC |
Delaware |
3712038 |
0 |
4062638 |
0 |
4062638 |
10.008 % |
12/10/2010 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
4062638 |
0 |
4062638 |
10.008 % |
12/10/2010 |
Wellington Management Company, LLP |
Massachusetts |
0 |
588100 |
0 |
2799600 |
2799600 |
6.51 % |
12/10/2010 |
Wellington Management Company, LLP |
Massachusetts |
0 |
588100 |
0 |
2799600 |
2799600 |
6.51 % |
12/10/2010 |
Putnam, LLC. d/b/a/ Putnam Investments |
Delaware |
0 |
50561 |
0 |
1656742 |
1656742 |
4.1 % |
08/10/2010 |
The Putnam Advisory Company, LLC. |
Delaware |
0 |
23164 |
0 |
27497 |
27497 |
0.1 % |
08/10/2010 |
Putnam Investment Management, LLC. |
Delaware |
0 |
27397 |
0 |
1629245 |
1629245 |
0 % |
08/10/2010 |
Vanguard Specialized Funds Vanguard Health Care Fund |
Delaware |
2000000 |
|
|
|
2000000 |
4.65 % |
07/10/2010 |
Morgan Stanley Investment Management Inc. |
The state of organization is Delaware. |
7982491 |
0 |
9370242 |
0 |
9370242 |
9.6 % |
10/03/2010 |
Morgan Stanley |
The state of organization is Delaware. |
9973299 |
0 |
11361050 |
0 |
11361050 |
11.7 % |
10/03/2010 |
Wellington Management Company, LLP |
Massachusetts |
0 |
1046600 |
0 |
3310000 |
3310000 |
17.27 % |
10/03/2010 |
Wellington Management Company, LLP |
Massachusetts |
0 |
1046600 |
0 |
3310000 |
3310000 |
17.27 % |
10/03/2010 |
The Putnam Advisory Company, LLC. |
Delaware |
0 |
23145 |
0 |
27192 |
27192 |
0.2 % |
10/03/2010 |
Putnam Investment Management, LLC. |
Delaware |
0 |
27397 |
0 |
1734354 |
1734354 |
10.4 % |
10/03/2010 |
Putnam, LLC. d/b/a/ Putnam Investments |
Delaware |
0 |
50542 |
0 |
1761546 |
1761546 |
10.6 % |
10/03/2010 |
VANGUARD SPECIALIZED FUNDS VANGUARD HEALTH CARE FUND: |
Delaware For |
2000000 |
0 |
0 |
0 |
2000000 |
10.43 % |
09/03/2010 |