| 13-3127734 |
Delaware |
1700509 |
0 |
1700509 |
0 |
1700509 |
2.77 % |
10/02/2022 |
| 26-0385758 |
Delaware |
1700509 |
0 |
1700509 |
0 |
1700509 |
2.77 % |
10/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania For |
0 |
56344 |
5414080 |
130621 |
5544701 |
9.02 % |
10/02/2022 |
| FMR LLC |
Delaware |
208936 |
0 |
1702656 |
0 |
1702656 |
2.764 % |
09/02/2022 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1702656 |
0 |
1702656 |
2.764 % |
09/02/2022 |
| JPMORGAN CHASE & CO.13-2624428 |
Delaware |
3033304 |
0 |
3246823 |
226 |
3248156 |
5.2 % |
24/01/2022 |
| 26-0385758 |
Delaware |
3099050 |
0 |
3099050 |
0 |
3099050 |
5.56 % |
11/02/2021 |
| 13-3127734 |
Delaware |
3099050 |
0 |
3099050 |
0 |
3099050 |
5.56 % |
11/02/2021 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
51993 |
4748290 |
129603 |
4877893 |
8.76 % |
10/02/2021 |
| FMR LLC |
Delaware |
580941 |
0 |
2927121 |
0 |
2927121 |
5.253 % |
08/02/2021 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2927121 |
0 |
2927121 |
5.253 % |
08/02/2021 |
| 26-0385758 |
Delaware |
3461524 |
0 |
3520790 |
28581 |
3549371 |
6.27 % |
12/02/2020 |
| 13-3127734 |
Delaware |
3461524 |
0 |
3520790 |
28581 |
3549371 |
6.27 % |
12/02/2020 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
45126 |
15840 |
4984379 |
56839 |
5041218 |
8.91 % |
12/02/2020 |
| 04-3543039 |
Delaware |
43072 |
0 |
45395 |
0 |
45395 |
0.1 % |
14/02/2019 |
| 26-1080669 |
Delaware |
47733 |
0 |
3144814 |
0 |
3144814 |
5.2 % |
14/02/2019 |
| 04-3542621 |
Delaware |
4661 |
0 |
3099419 |
0 |
3099419 |
5.1 % |
14/02/2019 |
| 04-3542621 |
Delaware |
4313 |
0 |
4935861 |
0 |
4935861 |
8.2 % |
10/07/2018 |
| 26-1080669 |
Delaware |
48482 |
0 |
4987399 |
0 |
4987399 |
8.3 % |
10/07/2018 |
| 04-3543039 |
Delaware |
44169 |
0 |
51537 |
0 |
51537 |
0.1 % |
10/07/2018 |
| 04-3543039 |
Delaware |
112945 |
0 |
120414 |
0 |
120414 |
0.2 % |
07/02/2018 |
| 26-4376599 |
Massachusetts |
0 |
0 |
5244777 |
0 |
5244777 |
8.7 % |
07/02/2018 |
| 04-3542621 |
Delaware |
716 |
0 |
8229296 |
0 |
8229296 |
13.7 % |
07/02/2018 |
| 26-1080669 |
Delaware |
113661 |
0 |
8349710 |
0 |
8349710 |
13.9 % |
07/02/2018 |
| 04-3542621 |
Delaware |
1380 |
0 |
7652569 |
0 |
7652569 |
12.8 % |
14/02/2017 |
| 04-3543039 |
Delaware |
76406 |
0 |
82138 |
0 |
82138 |
0.1 % |
14/02/2017 |
| 26-4376599 |
Massachusetts |
5418684 |
0 |
5418684 |
0 |
5418684 |
9 % |
14/02/2017 |
| 26-1080669 |
Delaware |
77786 |
0 |
7734707 |
0 |
7734707 |
12.9 % |
14/02/2017 |
| 26-1080669 |
Delaware |
131319 |
0 |
10478439 |
0 |
10478439 |
17 % |
16/02/2016 |
| 04-3543039 |
Delaware |
128210 |
0 |
155106 |
0 |
155106 |
0.3 % |
16/02/2016 |
| 26-4376599 |
Massachusetts |
6174984 |
0 |
6174984 |
0 |
6174984 |
10 % |
16/02/2016 |
| 04-3542621 |
Delaware |
3109 |
0 |
10323334 |
0 |
10323334 |
16.8 % |
16/02/2016 |
| FMR LLC |
Delaware |
525840 |
0 |
9182824 |
0 |
9182824 |
14.919 % |
12/02/2016 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
9182824 |
0 |
9182824 |
14.919 % |
12/02/2016 |
| 26-4376599 |
Massachusetts |
4394299 |
0 |
4394299 |
0 |
4394299 |
7.3 % |
17/02/2015 |
| 26-1080669 |
Delaware |
88296 |
0 |
7866934 |
0 |
7866934 |
13 % |
17/02/2015 |
| 04-3543039 |
Delaware |
87678 |
0 |
104673 |
0 |
104673 |
0.2 % |
17/02/2015 |
| 04-3542621 |
Delaware |
618 |
0 |
7762261 |
0 |
7762261 |
12.8 % |
17/02/2015 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
9091136 |
0 |
9091136 |
14.999 % |
13/02/2015 |
| FMR LLC |
Delaware |
512255 |
0 |
9091136 |
0 |
9091136 |
14.999 % |
13/02/2015 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
9091136 |
0 |
9091136 |
14.999 % |
13/02/2015 |
| FMR LLC |
Delaware |
548881 |
0 |
6076356 |
0 |
6080197 |
10.214 % |
12/05/2014 |
| 04-3542621 |
Delaware |
1450 |
0 |
6023897 |
0 |
6023897 |
10.1 % |
10/04/2014 |
| 26-1080669 |
Delaware |
75537 |
0 |
6102213 |
0 |
6102213 |
10.3 % |
10/04/2014 |
| 04-3543039 |
Delaware |
74087 |
0 |
78316 |
0 |
78316 |
0.1 % |
10/04/2014 |
| 26-4376599 |
Massachusetts |
3258363 |
0 |
3258363 |
0 |
3258363 |
5.5 % |
10/04/2014 |
| 04-3543039 |
Delaware |
73500 |
0 |
79037 |
0 |
79037 |
0.1 % |
14/02/2014 |
| 26-4376599 |
Massachusetts |
3028617 |
0 |
3028617 |
0 |
3028617 |
5.2 % |
14/02/2014 |
| 04-3542621 |
Delaware |
1618 |
0 |
5281565 |
0 |
5281565 |
9.1 % |
14/02/2014 |
| 26-1080669 |
Delaware |
75118 |
0 |
5360602 |
0 |
5360602 |
9.3 % |
14/02/2014 |
| (1) BlackRock, Inc. |
Delaware |
2273326 |
0 |
2273326 |
0 |
2273326 |
3.88 % |
10/07/2013 |
| (1) BlackRock, Inc. |
Delaware |
4157072 |
0 |
4157072 |
0 |
4157072 |
7.18 % |
30/01/2013 |
| LLC |
Delaware |
10504338 |
0 |
10504338 |
0 |
0 |
0 % |
31/01/2012 |
| LLC |
Delaware |
10504338 |
0 |
10504338 |
0 |
0 |
0 % |
31/01/2012 |
| LLC |
Delaware |
10504338 |
0 |
10504338 |
0 |
36445 |
0.1 % |
31/01/2012 |
| LLC |
Delaware |
10504338 |
0 |
10504338 |
0 |
10504338 |
24.6 % |
31/01/2012 |
| LLC |
Delaware |
10504338 |
0 |
10504338 |
0 |
10504338 |
24.6 % |
31/01/2012 |
| LLC |
Delaware |
10504338 |
0 |
10504338 |
0 |
0 |
0 % |
31/01/2012 |
| LLC |
Delaware |
10504338 |
0 |
10504338 |
0 |
0 |
0 % |
31/01/2012 |
| LLC |
Delaware |
10504338 |
0 |
10504338 |
0 |
36445 |
0.1 % |
31/01/2012 |
| LLC |
Delaware |
10504338 |
0 |
10504338 |
0 |
10504338 |
24.6 % |
31/01/2012 |
| (1) BlackRock, Inc. |
Delaware |
1458258 |
0 |
1458258 |
0 |
1458258 |
3.49 % |
07/10/2011 |
| Lehman Brothers Holdings Inc. |
Delaware |
1337941 |
0 |
1337941 |
0 |
1337941 |
3.3 % |
15/02/2011 |
| Versant Affiliates Fund II-A, L.P. |
Delaware United States America |
30724 |
0 |
30724 |
0 |
30724 |
0.08 % |
14/02/2011 |
| Bridger Management, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2011 |
| Roberto Mignone |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2011 |
| (1) BlackRock, Inc. |
Delaware |
3458174 |
0 |
3458174 |
0 |
3458174 |
8.89 % |
04/02/2011 |
| Swiftcurrent Offshore, Ltd. |
Cayman Islands |
0 |
835250 |
0 |
0 |
835250 |
2.7 % |
12/02/2010 |
| Prospect Associates II, L.P. |
Delaware, United States of America |
0 |
0 |
0 |
1510145 |
1510145 |
4.9 % |
11/02/2010 |
| Prospect Management Co. II, L.L.C. |
Delaware, United States of America |
0 |
0 |
0 |
1510145 |
1510145 |
4.9 % |
11/02/2010 |
| Prospect Venture Partners II, L.P. |
Delaware, United States of America |
0 |
0 |
0 |
1510145 |
1510145 |
4.9 % |
11/02/2010 |
| Roberto Mignone |
United States |
0 |
2667050 |
0 |
2667050 |
2667050 |
9.27 % |
13/02/2009 |
| Bridger Management, LLC |
Delaware |
0 |
2667050 |
0 |
2667050 |
2667050 |
9.27 % |
13/02/2009 |
| Swiftcurrent Offshore, Ltd. |
Cayman Islands |
0 |
1560250 |
0 |
1560250 |
1560250 |
5.42 % |
13/02/2009 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
154103 |
0 |
154103 |
0.536 % |
10/12/2008 |
| FMR LLC |
Delaware |
0 |
0 |
154103 |
0 |
154103 |
0.536 % |
10/12/2008 |
| 11-2751029 |
Delaware |
1700 |
0 |
1700 |
0 |
1700 |
0 % |
27/03/2008 |
| 13-4184631 |
Delaware |
25 |
0 |
25 |
0 |
25 |
0 % |
27/03/2008 |
| 13-4143945 |
Delaware |
142858 |
0 |
142858 |
0 |
142858 |
0.6 % |
27/03/2008 |
| 13-2741778 |
Delaware |
1366414 |
0 |
1366414 |
0 |
1366414 |
5.3 % |
27/03/2008 |
| 52-2278632 |
Delaware |
317076 |
0 |
317076 |
0 |
317076 |
1.3 % |
27/03/2008 |
| 13-3555152 |
Delaware |
317076 |
0 |
317076 |
0 |
317076 |
1.3 % |
27/03/2008 |
| 13-3695935 |
Delaware |
317076 |
0 |
317076 |
0 |
317076 |
1.3 % |
27/03/2008 |
| 03-0454303 |
Delaware |
165661 |
0 |
165661 |
0 |
165661 |
0.7 % |
27/03/2008 |
| 13-3216325 |
Delaware |
1685253 |
0 |
1685253 |
0 |
1685253 |
6.6 % |
27/03/2008 |
| 13-2518466 |
Delaware |
1368152 |
0 |
1368152 |
0 |
1368152 |
5.4 % |
27/03/2008 |
| 03-0454314 |
Delaware |
165661 |
0 |
165661 |
0 |
165661 |
0.7 % |
27/03/2008 |
| N/A |
Bermuda |
37050 |
0 |
37050 |
0 |
37050 |
0.2 % |
27/03/2008 |
| N/A |
Bermuda |
37050 |
0 |
37050 |
0 |
37050 |
0.2 % |
27/03/2008 |
| 52-2038758 |
Bermuda |
37050 |
0 |
37050 |
0 |
37050 |
0.2 % |
27/03/2008 |
| Bridger
Management, LLC |
OR PLACE OF ORGANIZATION: |
0 |
0 |
0 |
2567049 |
2567049 |
10.46 % |
19/03/2008 |
| Roberto
Mignone |
OR PLACE OF ORGANIZATION: |
0 |
0 |
0 |
2567049 |
2567049 |
10.46 % |
19/03/2008 |
| Swiftcurrent
Offshore, Ltd. |
OR PLACE OF ORGANIZATION: |
0 |
0 |
0 |
1509449 |
1509449 |
6.15 % |
19/03/2008 |
| FMR LLC |
Delaware |
0 |
0 |
1519125 |
0 |
1519125 |
6.188 % |
14/02/2008 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
1519125 |
0 |
1519125 |
6.188 % |
14/02/2008 |
| Management, LLC |
Delaware |
0 |
2225990 |
0 |
0 |
2225990 |
9.07 % |
13/02/2008 |
| Offshore, Ltd. |
Islands |
0 |
1359890 |
0 |
0 |
1359890 |
5.54 % |
13/02/2008 |
| Mignone |
States |
0 |
2225990 |
0 |
0 |
2225990 |
9.07 % |
13/02/2008 |
| VERSANT SIDE FUND II, L.P |
: |
0 |
0 |
0 |
0 |
10730 |
0.04 % |
13/02/2008 |
| WILLIAM J. LINK |
: |
0 |
0 |
0 |
1234161 |
1234161 |
5 % |
13/02/2008 |
| VERSANT AFFILIATES FUND II-A, LP |
: |
0 |
0 |
0 |
0 |
22784 |
0.1 % |
13/02/2008 |
| VERSANT VENTURES II, LLC |
: |
0 |
0 |
0 |
0 |
1234161 |
5 % |
13/02/2008 |
| VERSANT VENTURE CAPITAL II, L.P. |
: |
0 |
0 |
0 |
0 |
1200647 |
4.9 % |
13/02/2008 |
| CAMILLE D. SAMUELS |
: |
0 |
0 |
0 |
1234161 |
1234161 |
5 % |
13/02/2008 |
| REBECCA B. ROBERTSON |
: |
0 |
0 |
0 |
1234161 |
1234161 |
5 % |
13/02/2008 |
| DONALD B. MILDER |
: |
0 |
0 |
0 |
1234161 |
1234161 |
5 % |
13/02/2008 |
| SAMUEL D. COLELLA |
: |
0 |
0 |
0 |
1234161 |
1244161 |
5.1 % |
13/02/2008 |
| BRADLEY J. BOLZON |
: |
0 |
0 |
0 |
1234161 |
1234161 |
5 % |
13/02/2008 |
| CHARLES M. WARDEN |
: |
0 |
0 |
0 |
1234161 |
1234161 |
5 % |
13/02/2008 |
| BARBARA N. LUBASH |
: |
0 |
0 |
0 |
1234161 |
1234161 |
5 % |
13/02/2008 |
| ROSS A. JAFFE |
: |
0 |
0 |
0 |
1234161 |
1234161 |
5 % |
13/02/2008 |
| BRIAN G. ATWOOD |
: |
0 |
0 |
0 |
1234161 |
1234161 |
5 % |
13/02/2008 |
| Bridger Management, LLC |
Delaware |
0 |
1319800 |
0 |
1319800 |
1319800 |
5.38 % |
11/06/2007 |
| Roberto Mignone |
United States |
0 |
1319800 |
0 |
1319800 |
1319800 |
5.38 % |
11/06/2007 |