| BlackRock, Inc. |
Delaware |
22009461 |
0 |
22452115 |
0 |
22452115 |
6 % |
08/11/2024 |
| The Vanguard Group |
Pennsylvania |
0 |
262926 |
16791764 |
500328 |
17292092 |
4.65 % |
04/11/2024 |
| Indaba Capital Management, L.P. |
Delaware |
0 |
7975374 |
0 |
7975374 |
7975374 |
9.9 % |
14/02/2024 |
| Derek C. Schrier |
Delaware |
0 |
7975374 |
0 |
7975374 |
7975374 |
9.9 % |
14/02/2024 |
| IC GP, LLC |
Delaware |
0 |
7975374 |
0 |
7975374 |
7975374 |
9.9 % |
14/02/2024 |
| Viking Global Opportunities Portfolio GP LLC |
Delaware |
0 |
19501727 |
0 |
19501727 |
19501727 |
6.4 % |
09/01/2024 |
| Viking Global Opportunities Drawdown GP LLC |
Delaware |
0 |
9604638 |
0 |
9604638 |
9604638 |
3.1 % |
09/01/2024 |
| Viking Global Opportunities Drawdown Portfolio GP LLC |
Delaware |
0 |
9604638 |
0 |
9604638 |
9604638 |
3.1 % |
09/01/2024 |
| Viking Global Opportunities Drawdown |
Cayman Islands |
0 |
9604638 |
0 |
9604638 |
9604638 |
3.1 % |
09/01/2024 |
| O. Andreas Halvorsen |
Norway |
0 |
29106365 |
0 |
29106365 |
29106365 |
9.5 % |
09/01/2024 |
| David C. Ott |
United States |
0 |
29106365 |
0 |
29106365 |
29106365 |
9.5 % |
09/01/2024 |
| Rose S. Shabet |
United States |
0 |
29106365 |
0 |
29106365 |
29106365 |
9.5 % |
09/01/2024 |
| Rose S. Shabet |
United States |
0 |
29106365 |
0 |
29106365 |
29106365 |
9.5 % |
09/01/2024 |
| David C. Ott |
United States |
0 |
29106365 |
0 |
29106365 |
29106365 |
9.5 % |
09/01/2024 |
| O. Andreas Halvorsen |
Norway |
0 |
29106365 |
0 |
29106365 |
29106365 |
9.5 % |
09/01/2024 |
| Viking Global Opportunities Drawdown |
Cayman Islands |
0 |
9604638 |
0 |
9604638 |
9604638 |
3.1 % |
09/01/2024 |
| Viking Global Opportunities Drawdown Portfolio GP LLC |
Delaware |
0 |
9604638 |
0 |
9604638 |
9604638 |
3.1 % |
09/01/2024 |
| Viking Global Opportunities Drawdown GP LLC |
Delaware |
0 |
9604638 |
0 |
9604638 |
9604638 |
3.1 % |
09/01/2024 |
| Viking Global Opportunities Parent GP LLC |
Delaware |
0 |
29106365 |
0 |
29106365 |
29106365 |
9.5 % |
09/01/2024 |
| Viking Global Investors LP |
Delaware |
0 |
29106365 |
0 |
29106365 |
29106365 |
9.5 % |
09/01/2024 |
| Viking Global Opportunities Portfolio GP LLC |
Delaware |
0 |
19501727 |
0 |
19501727 |
19501727 |
6.4 % |
09/01/2024 |
| Viking Global Opportunities GP LLC |
Delaware |
0 |
19501727 |
0 |
19501727 |
19501727 |
6.4 % |
09/01/2024 |
| Viking Global Opportunities Parent GP LLC |
Delaware |
0 |
29106365 |
0 |
29106365 |
29106365 |
9.5 % |
09/01/2024 |
| Viking Global Investors LP |
Delaware |
0 |
29106365 |
0 |
29106365 |
29106365 |
9.5 % |
09/01/2024 |
| Viking Global Opportunities Illiquid Investments LP |
Cayman Islands |
0 |
19501727 |
0 |
19501727 |
19501727 |
6.4 % |
09/01/2024 |
| Viking Global Opportunities Illiquid Investments LP |
Cayman Islands |
0 |
19501727 |
0 |
19501727 |
19501727 |
6.4 % |
09/01/2024 |
| Viking Global Opportunities GP LLC |
Delaware |
0 |
19501727 |
0 |
19501727 |
19501727 |
6.4 % |
09/01/2024 |
| PRIMECAP Management Company |
E Colorado Blvd th Floor Pasadena CA |
3220917 |
0 |
3220917 |
0 |
3220917 |
4.11 % |
07/07/2023 |
| IC GP, LLC |
Delaware |
0 |
7894751 |
0 |
7894751 |
7894751 |
9.9 % |
14/02/2023 |
| Indaba Capital Management, L.P. |
Delaware |
0 |
7894751 |
0 |
7894751 |
7894751 |
9.9 % |
14/02/2023 |
| IC GP, LLC |
Delaware |
0 |
7894751 |
0 |
7894751 |
7894751 |
9.9 % |
14/02/2023 |
| Derek C. Schrier |
Delaware |
0 |
7894751 |
0 |
7894751 |
7894751 |
9.9 % |
14/02/2023 |
| Derek C. Schrier |
Delaware |
0 |
7894751 |
0 |
7894751 |
7894751 |
9.9 % |
14/02/2023 |
| Indaba Capital Management, L.P. |
Delaware |
0 |
7894751 |
0 |
7894751 |
7894751 |
9.9 % |
14/02/2023 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2022 |
| Rajeev Shah |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2022 |
| Peter Kolchinsky |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2022 |
| RA Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2022 |
| BlackRock, Inc. |
Delaware |
2014605 |
0 |
2017210 |
0 |
2017210 |
2.6 % |
08/07/2022 |
| David C. Ott |
United States |
0 |
8103527 |
0 |
8103527 |
8103527 |
9.5 % |
14/04/2022 |
| Viking Global Opportunities Drawdown |
Cayman Islands |
0 |
2674117 |
0 |
2674117 |
2674117 |
3.1 % |
14/04/2022 |
| Viking Global Opportunities Drawdown Portfolio GP LLC |
Delaware |
0 |
2674117 |
0 |
2674117 |
2674117 |
3.1 % |
14/04/2022 |
| O. Andreas Halvorsen |
Norway |
0 |
8103527 |
0 |
8103527 |
8103527 |
9.5 % |
14/04/2022 |
| Viking Global Opportunities Illiquid Investments LP |
Cayman Islands |
0 |
5429410 |
0 |
5429410 |
5429410 |
6.4 % |
14/04/2022 |
| Viking Global Opportunities GP LLC |
Delaware |
0 |
5429410 |
0 |
5429410 |
5429410 |
6.4 % |
14/04/2022 |
| Viking Global Opportunities Portfolio GP LLC |
Delaware |
0 |
5429410 |
0 |
5429410 |
5429410 |
6.4 % |
14/04/2022 |
| Viking Global Opportunities Parent GP LLC |
Delaware |
0 |
8103527 |
0 |
8103527 |
8103527 |
9.5 % |
14/04/2022 |
| Viking Global Investors LP |
Delaware |
0 |
8103527 |
0 |
8103527 |
8103527 |
9.5 % |
14/04/2022 |
| Viking Global Opportunities Drawdown GP LLC |
Delaware |
0 |
2674117 |
0 |
2674117 |
2674117 |
3.1 % |
14/04/2022 |
| Rose S. Shabet |
United States |
0 |
8103527 |
0 |
8103527 |
8103527 |
9.5 % |
14/04/2022 |
| Rajeev Shah |
United States of America |
0 |
4651177 |
0 |
4651177 |
4651177 |
6 % |
24/03/2022 |
| RA Capital Management, L.P. |
Delaware |
0 |
4651177 |
0 |
4651177 |
4651177 |
6 % |
24/03/2022 |
| Peter Kolchinsky |
United States of America |
0 |
4651177 |
0 |
4651177 |
4651177 |
6 % |
24/03/2022 |
| Rajeev Shah |
United States of America |
0 |
4651177 |
0 |
4651177 |
4651177 |
6 % |
24/03/2022 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
4651177 |
0 |
4651177 |
4651177 |
6 % |
24/03/2022 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
4651177 |
0 |
4651177 |
4651177 |
6 % |
24/03/2022 |
| Peter Kolchinsky |
United States of America |
0 |
4651177 |
0 |
4651177 |
4651177 |
6 % |
24/03/2022 |
| RA Capital Management, L.P. |
Delaware |
0 |
4651177 |
0 |
4651177 |
4651177 |
6 % |
24/03/2022 |
| Brian Miller |
United States of America |
4375000 |
0 |
4375000 |
0 |
4375000 |
5.7 % |
07/03/2022 |
| PN CUSIP No. 34385P108 SCHEDULE 13G 1 NAME OF REPORTING PERSON North Sound Management, Inc. 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Delaware |
2500000 |
0 |
2500000 |
0 |
2500000 |
3.2 % |
07/03/2022 |
| PN CUSIP No. 34385P108 SCHEDULE 13G 1 NAME OF REPORTING PERSON North Sound Management, Inc. 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Delaware |
2500000 |
0 |
2500000 |
0 |
2500000 |
3.2 % |
07/03/2022 |
| Brian Miller |
United States of America |
4375000 |
0 |
4375000 |
0 |
4375000 |
5.7 % |
07/03/2022 |
| IC GP, LLC |
Delaware |
0 |
7585905 |
0 |
7585905 |
7585905 |
9.9 % |
14/02/2022 |
| Indaba Capital Management, L.P. |
Delaware |
0 |
7585905 |
0 |
7585905 |
7585905 |
9.9 % |
14/02/2022 |
| Derek C. Schrier |
United States |
0 |
7585905 |
0 |
7585905 |
7585905 |
9.9 % |
14/02/2022 |
| OrbiMed Advisors LLC |
Delaware |
0 |
402477 |
0 |
402477 |
402477 |
0.53 % |
11/02/2022 |
| OrbiMed Capital LLC |
Delaware |
3416871 |
0 |
3416871 |
0 |
3416871 |
4.46 % |
11/02/2022 |
| OrbiMed Advisors LLC |
Delaware |
0 |
402477 |
0 |
402477 |
402477 |
0.53 % |
11/02/2022 |
| OrbiMed Capital LLC |
Delaware |
3416871 |
0 |
3416871 |
0 |
3416871 |
4.46 % |
11/02/2022 |
| The Vanguard Group |
Pennsylvania |
0 |
67169 |
3744688 |
122983 |
3867671 |
5.06 % |
10/02/2022 |
| BlackRock, Inc. |
Delaware |
6129387 |
0 |
6251230 |
0 |
6251230 |
8.2 % |
02/02/2022 |
| IC GP, LLC |
Delaware |
0 |
7536350 |
0 |
7536350 |
7536350 |
9.9 % |
16/02/2021 |
| IC GP, LLC |
Delaware |
0 |
7536350 |
0 |
7536350 |
7536350 |
9.9 % |
16/02/2021 |
| Indaba Capital Management, L.P. |
Delaware |
0 |
7536350 |
0 |
7536350 |
7536350 |
9.9 % |
16/02/2021 |
| Derek C. Schrier |
United States |
0 |
7536350 |
0 |
7536350 |
7536350 |
9.9 % |
16/02/2021 |
| Derek C. Schrier |
United States |
0 |
7536350 |
0 |
7536350 |
7536350 |
9.9 % |
16/02/2021 |
| Indaba Capital Management, L.P. |
Delaware |
0 |
7536350 |
0 |
7536350 |
7536350 |
9.9 % |
16/02/2021 |
| Levin Easterly Partners LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Easterly Asset Management GP LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Easterly Asset Management LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| LE Partners Holdings III LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| LE Partners Holdings II LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| LE Partners Holdings LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| John Murphy |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Darrell Crate |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Levin Easterly Partners LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| LE Partners Holdings LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| LE Partners Holdings II LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| LE Partners Holdings III LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Easterly Asset Management LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Easterly Asset Management GP LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Darrell Crate |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| John Murphy |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| OrbiMed Capital LLC |
Delaware |
3499246 |
0 |
3499246 |
0 |
3499246 |
4.72 % |
12/02/2021 |
| OrbiMed Advisors LLC |
Delaware |
0 |
393100 |
0 |
393100 |
393100 |
0.53 % |
12/02/2021 |
| OrbiMed Advisors LLC |
Delaware |
0 |
393100 |
0 |
393100 |
393100 |
0.53 % |
12/02/2021 |
| OrbiMed Capital LLC |
Delaware |
3499246 |
0 |
3499246 |
0 |
3499246 |
4.72 % |
12/02/2021 |
| PRIMECAP Management Company |
E Colorado Blvd th Floor Pasadena CA |
5433843 |
0 |
5433843 |
0 |
5433843 |
7.33 % |
12/02/2021 |
| Neuberger Berman Group LLC |
Delaware |
0 |
3821970 |
0 |
4644554 |
4644554 |
6.27 % |
11/02/2021 |
| Neuberger Berman Investment Advisers LLC |
Delaware |
0 |
3821970 |
0 |
4644554 |
4644554 |
6.27 % |
11/02/2021 |
| The Vanguard Group |
Pennsylvania |
0 |
91614 |
3324753 |
151557 |
3476310 |
4.69 % |
10/02/2021 |
| BlackRock, Inc. |
Delaware |
5466965 |
0 |
5577959 |
0 |
5577959 |
7.5 % |
29/01/2021 |
| Derek C. Schrier |
United States |
0 |
7278524 |
0 |
7278524 |
7278524 |
9.9 % |
14/02/2020 |
| IC GP, LLC |
Delaware |
0 |
7278524 |
0 |
7278524 |
7278524 |
9.9 % |
14/02/2020 |
| Indaba Capital Management, L.P. |
Delaware |
0 |
7278524 |
0 |
7278524 |
7278524 |
9.9 % |
14/02/2020 |
| Neuberger Berman Group LLC |
Delaware |
0 |
4622395 |
0 |
5669341 |
5669341 |
8.15 % |
14/02/2020 |
| Neuberger Berman Investment Advisers LLC |
Delaware |
0 |
4622395 |
0 |
5669341 |
5669341 |
8.15 % |
14/02/2020 |
| LE Partners Holdings II LLC |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| LE Partners Holdings LLC |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| Levin Easterly Partners LLC |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| LE Partners Holdings III LLC |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| LE Partners Holdings IV LLC |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| Darrell Crate |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| Avshalom Kalichstein |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| John Murphy |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| LE Partners Holdings II LLC |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| LE Partners Holdings III LLC |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| LE Partners Holdings IV LLC |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| John Murphy |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| Darrell Crate |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| Avshalom Kalichstein |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| Levin Easterly Partners LLC |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| LE Partners Holdings LLC |
Delaware |
0 |
4065867 |
0 |
5128573 |
5128573 |
7.4 % |
13/02/2020 |
| PRIMECAP Management Company |
|
|
|
|
|
6477843 |
9.31 % |
12/02/2020 |
| The Vanguard Group |
Pennsylvania |
147604 |
5387 |
4264839 |
144937 |
4409776 |
6.33 % |
11/02/2020 |
| BlackRock, Inc. |
Delaware |
5186586 |
0 |
5290321 |
0 |
5290321 |
7.6 % |
07/02/2020 |
| Levin Capital Strategies, L.P. |
Delaware |
0 |
4996 |
0 |
4996 |
4996 |
0 % |
16/08/2019 |
| John Murphy |
Delaware |
0 |
5553791 |
0 |
8276607 |
8276607 |
11.9 % |
16/08/2019 |
| Avshalom Kalichstein |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| LE Partners Holdings LLC |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| Darrell Crate |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| LE Partners Holdings LLC |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| Levin Easterly Partners LLC |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| Levin Capital Strategies, L.P. |
Delaware |
0 |
4996 |
0 |
4996 |
4996 |
0 % |
16/08/2019 |
| John Murphy |
Delaware |
0 |
5553791 |
0 |
8276607 |
8276607 |
11.9 % |
16/08/2019 |
| Levin Easterly Partners LLC |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| Avshalom Kalichstein |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| LE Partners Holdings IV LLC |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| LE Partners Holdings III LLC |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| Darrell Crate |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| LE Partners Holdings III LLC |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| LE Partners Holdings IV LLC |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| LE Partners Holdings II LLC |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| LE Partners Holdings II LLC |
Delaware |
0 |
5548795 |
0 |
8271611 |
8271611 |
11.9 % |
16/08/2019 |
| John Murphy |
Delaware |
0 |
8965855 |
0 |
12231426 |
12231426 |
17.7 % |
08/04/2019 |
| LE Partners Holdings LLC |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| Levin Easterly Partners LLC |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| Levin Capital Strategies, LP |
Delaware |
0 |
4996 |
0 |
4996 |
4996 |
0 % |
08/04/2019 |
| Avshalom Kalichstein |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| Darrell Crate |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| LE Partners Holdings IV LLC |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| LE Partners Holdings III LLC |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| LE Partners Holdings II LLC |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| LE Partners Holdings LLC |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| Levin Capital Strategies, LP |
Delaware |
0 |
4996 |
0 |
4996 |
4996 |
0 % |
08/04/2019 |
| John Murphy |
Delaware |
0 |
8965855 |
0 |
12231426 |
12231426 |
17.7 % |
08/04/2019 |
| Avshalom Kalichstein |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| Darrell Crate |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| LE Partners Holdings IV LLC |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| LE Partners Holdings III LLC |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| LE Partners Holdings II LLC |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| Levin Easterly Partners LLC |
Delaware |
0 |
8960859 |
0 |
12226430 |
12226430 |
17.7 % |
08/04/2019 |
| Neuberger Berman Group LLC |
Delaware |
0 |
4392178 |
0 |
5464974 |
5464974 |
11.22 % |
14/02/2019 |
| Neuberger Berman Investment Advisers LLC |
Delaware |
0 |
4392178 |
0 |
5464974 |
5464974 |
11.22 % |
14/02/2019 |
| OrbiMed Capital LLC |
Delaware |
0 |
0 |
0 |
|
0 |
0 % |
12/02/2019 |
| OrbiMed Advisors LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2019 |
| PRIMECAP Management Company |
|
|
|
|
|
6671043 |
13.7 % |
08/02/2019 |
| BlackRock, Inc. |
Delaware |
1907552 |
0 |
1949235 |
0 |
1949235 |
4.97 % |
09/11/2018 |
| Russell Investments Group, Ltd. |
Seattle, WA USA |
2250881 |
|
|
2250881 |
2250881 |
5.8 % |
18/07/2018 |
| Russell Investments Group, Ltd. |
Seattle, WA USA |
2250881 |
|
|
2250881 |
2250881 |
5.8 % |
18/07/2018 |
| PRIMECAP Management Company |
|
|
|
|
|
5775143 |
14.94 % |
27/02/2018 |
| Neuberger Berman Investment Advisers LLC |
Delaware |
0 |
3854423 |
0 |
4734734 |
4734734 |
12.25 % |
14/02/2018 |
| Neuberger Berman Group LLC |
Delaware |
0 |
3854423 |
0 |
4734734 |
4734734 |
12.25 % |
14/02/2018 |
| OrbiMed Capital LLC |
Delaware |
0 |
1467120 |
0 |
|
1467120 |
3.79 % |
13/02/2018 |
| OrbiMed Advisors LLC |
Delaware |
0 |
295330 |
0 |
295330 |
295330 |
0.76 % |
13/02/2018 |
| Robert Atchinson |
United States |
0 |
1184133 |
0 |
1184133 |
1184133 |
3.06 % |
13/02/2018 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
1184133 |
0 |
1184133 |
1184133 |
3.06 % |
13/02/2018 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
1184133 |
0 |
1184133 |
1184133 |
3.06 % |
13/02/2018 |
| Robert Atchinson |
United States |
0 |
1184133 |
0 |
1184133 |
1184133 |
3.06 % |
13/02/2018 |
| Phillip Gross |
United States |
0 |
1184133 |
0 |
1184133 |
1184133 |
3.06 % |
13/02/2018 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
1184133 |
0 |
1184133 |
1184133 |
3.06 % |
13/02/2018 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
1184133 |
0 |
1184133 |
1184133 |
3.06 % |
13/02/2018 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
1184133 |
0 |
1184133 |
1184133 |
3.06 % |
13/02/2018 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
1184133 |
0 |
1184133 |
1184133 |
3.06 % |
13/02/2018 |
| Phillip Gross |
United States |
0 |
1184133 |
0 |
1184133 |
1184133 |
3.06 % |
13/02/2018 |
| BlackRock, Inc. |
Delaware |
2139653 |
0 |
2184882 |
0 |
2184882 |
5.7 % |
01/02/2018 |
| BlackRock, Inc. |
Delaware |
1808538 |
0 |
1847243 |
0 |
1847243 |
4.8 % |
10/10/2017 |
| Neuberger Berman Group LLC |
Delaware |
0 |
4504232 |
0 |
5254297 |
5254297 |
13.65 % |
08/09/2017 |
| Neuberger Berman Group LLC |
Delaware |
0 |
4504232 |
0 |
5254297 |
5254297 |
13.65 % |
08/09/2017 |
| Neuberger Berman Investment Advisers LLC |
Delaware |
0 |
4504232 |
0 |
5254297 |
5254297 |
13.65 % |
08/09/2017 |
| Neuberger Berman Investment Advisers LLC |
Delaware |
0 |
4504232 |
0 |
5254297 |
5254297 |
13.65 % |
08/09/2017 |
| PRIMECAP Management Company |
|
|
|
|
|
5775143 |
15 % |
07/09/2017 |
| PRIMECAP Management Company |
|
|
|
|
|
5775143 |
15 % |
07/09/2017 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
1546209 |
0 |
1546209 |
1546209 |
5.29 % |
13/03/2017 |
| Phillip Gross |
United States |
0 |
1546209 |
0 |
1546209 |
1546209 |
5.29 % |
13/03/2017 |
| Robert Atchinson |
United States |
0 |
1546209 |
0 |
1546209 |
1546209 |
5.29 % |
13/03/2017 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
1546209 |
0 |
1546209 |
1546209 |
5.29 % |
13/03/2017 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
1546209 |
0 |
1546209 |
1546209 |
5.29 % |
13/03/2017 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
1546209 |
0 |
1546209 |
1546209 |
5.29 % |
13/03/2017 |
| Phillip Gross |
United States |
0 |
1546209 |
0 |
1546209 |
1546209 |
5.29 % |
13/03/2017 |
| Robert Atchinson |
United States |
0 |
1546209 |
0 |
1546209 |
1546209 |
5.29 % |
13/03/2017 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
1546209 |
0 |
1546209 |
1546209 |
5.29 % |
13/03/2017 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
1546209 |
0 |
1546209 |
1546209 |
5.29 % |
13/03/2017 |
| Matthew Sirovich |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Jeremy Mindich |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Scopia Management, Inc. |
New York |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Scopia Capital Management LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Scopia Management, Inc. |
New York |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Matthew Sirovich |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Jeremy Mindich |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Scopia Capital Management LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Samuel D. Isaly |
United States |
0 |
2056861 |
0 |
2056861 |
2056861 |
7.02 % |
13/02/2017 |
| OrbiMed Advisors LLC |
Delaware |
0 |
361842 |
0 |
361842 |
361842 |
1.24 % |
13/02/2017 |
| OrbiMed Capital LLC |
Delaware |
0 |
1695019 |
0 |
0 |
1695019 |
5.8 % |
13/02/2017 |
| PRIMECAP Management Company |
|
|
|
|
|
4295532 |
14.79 % |
09/02/2017 |
| PRIMECAP Management Company |
|
|
|
|
|
4295532 |
14.79 % |
09/02/2017 |
| BlackRock, Inc. |
Delaware |
1781934 |
0 |
1827699 |
0 |
1827699 |
6.3 % |
23/01/2017 |
| Columbia Wanger Asset Management, LLC |
Delaware |
|
|
|
|
0 |
0 % |
07/10/2016 |
| S LCS, LLC |
A Delaware |
61068 |
0 |
61068 |
0 |
0 |
1 % |
30/09/2016 |
| S Levin Capital Strategies, L.P. |
A Delaware |
122971 |
4164216 |
122971 |
5571697 |
5694668 |
19.6 % |
30/09/2016 |
| S LCS L/S, LLC |
A Delaware |
9252 |
0 |
9252 |
0 |
9252 |
1 % |
30/09/2016 |
| S LCS, LLC |
A Delaware |
61068 |
0 |
61068 |
0 |
0 |
1 % |
30/09/2016 |
| S LCS Event Partners, LLC |
A Delaware |
16289 |
0 |
16289 |
0 |
16289 |
1 % |
30/09/2016 |
| S Levin Capital Strategies, L.P. |
A Delaware |
122971 |
4164216 |
122971 |
5571697 |
5694668 |
19.6 % |
30/09/2016 |
| S John A. Levin |
United States America |
0 |
0 |
0 |
0 |
0 |
0 % |
30/09/2016 |
| S LCS L/S, LLC |
A Delaware |
9252 |
0 |
9252 |
0 |
9252 |
1 % |
30/09/2016 |
| S LCS Event Partners, LLC |
A Delaware |
16289 |
0 |
16289 |
0 |
16289 |
1 % |
30/09/2016 |
| S John A. Levin |
United States America |
0 |
0 |
0 |
0 |
0 |
0 % |
30/09/2016 |
| S LCS L/S, LLC |
A Delaware |
8205 |
0 |
8205 |
0 |
8205 |
1 % |
06/04/2016 |
| S LCS, LLC |
A Delaware |
82082 |
0 |
82082 |
0 |
0 |
1 % |
06/04/2016 |
| S Levin Capital Strategies, L.P. |
A Delaware |
95591 |
1919850 |
95591 |
2973968 |
3069559 |
10.6 % |
06/04/2016 |
| S LCS, LLC |
A Delaware |
82082 |
0 |
82082 |
0 |
0 |
1 % |
06/04/2016 |
| S LCS Event Partners, LLC |
A Delaware |
5304 |
0 |
5304 |
0 |
5304 |
1 % |
06/04/2016 |
| S LCS L/S, LLC |
A Delaware |
8205 |
0 |
8205 |
0 |
8205 |
1 % |
06/04/2016 |
| S John A. Levin |
United States America |
0 |
0 |
0 |
0 |
0 |
0 % |
06/04/2016 |
| S LCS Event Partners, LLC |
A Delaware |
5304 |
0 |
5304 |
0 |
5304 |
1 % |
06/04/2016 |
| S Levin Capital Strategies, L.P. |
A Delaware |
95591 |
1919850 |
95591 |
2973968 |
3069559 |
10.6 % |
06/04/2016 |
| S John A. Levin |
United States America |
0 |
0 |
0 |
0 |
0 |
0 % |
06/04/2016 |
| S Levin Capital Strategies, L.P. |
A Delaware |
49684 |
1797550 |
49684 |
2779726 |
2829410 |
9.8 % |
18/03/2016 |
| S John A. Levin |
United States America |
0 |
0 |
0 |
0 |
0 |
0 % |
18/03/2016 |
| S LCS Event Partners, LLC |
A Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
18/03/2016 |
| S LCS, LLC |
A Delaware |
47158 |
0 |
47158 |
0 |
0 |
1 % |
18/03/2016 |
| S Levin Capital Strategies, L.P. |
A Delaware |
49684 |
1797550 |
49684 |
2779726 |
2829410 |
9.8 % |
18/03/2016 |
| S LCS, LLC |
A Delaware |
47158 |
0 |
47158 |
0 |
0 |
1 % |
18/03/2016 |
| S LCS L/S, LLC |
A Delaware |
2526 |
0 |
2526 |
0 |
0 |
1 % |
18/03/2016 |
| S John A. Levin |
United States America |
0 |
0 |
0 |
0 |
0 |
0 % |
18/03/2016 |
| S LCS L/S, LLC |
A Delaware |
2526 |
0 |
2526 |
0 |
0 |
1 % |
18/03/2016 |
| S LCS Event Partners, LLC |
A Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
18/03/2016 |
| OrbiMed Advisors LLC |
Delaware |
0 |
967830 |
0 |
967830 |
967830 |
3.34 % |
16/02/2016 |
| Samuel D. Isaly |
United States |
0 |
2628650 |
0 |
2628650 |
2628650 |
9.07 % |
16/02/2016 |
| OrbiMed Capital LLC |
Delaware |
0 |
1660820 |
0 |
0 |
1660820 |
5.73 % |
16/02/2016 |
| Scopia Management, Inc. |
United States |
0 |
1508120 |
0 |
1508120 |
1508120 |
5.24 % |
16/02/2016 |
| Scopia Capital Management LP |
United States |
0 |
1508120 |
0 |
1508120 |
1508120 |
5.24 % |
16/02/2016 |
| Jeremy Mindich |
United States |
0 |
1508120 |
0 |
1508120 |
1508120 |
5.24 % |
16/02/2016 |
| Jeremy Mindich |
United States |
0 |
1508120 |
0 |
1508120 |
1508120 |
5.24 % |
16/02/2016 |
| Matthew Sirovich |
United States |
0 |
1508120 |
0 |
1508120 |
1508120 |
5.24 % |
16/02/2016 |
| Scopia Management, Inc. |
United States |
0 |
1508120 |
0 |
1508120 |
1508120 |
5.24 % |
16/02/2016 |
| Matthew Sirovich |
United States |
0 |
1508120 |
0 |
1508120 |
1508120 |
5.24 % |
16/02/2016 |
| Scopia Capital Management LP |
United States |
0 |
1508120 |
0 |
1508120 |
1508120 |
5.24 % |
16/02/2016 |
| PRIMECAP Management Company |
|
|
|
|
|
4266432 |
14.82 % |
12/02/2016 |
| PRIMECAP Management Company |
|
|
|
|
|
4266432 |
14.82 % |
12/02/2016 |
| MDC Capital Limited, as trustee for Fifty Ft Investment Company LLC |
Cayman Islands |
0 |
1599069 |
0 |
1599069 |
1599069 |
5.55 % |
11/02/2016 |
| Mubadala Development Company PJSC |
Emirate Abu Dhabi United Arab Emirates |
0 |
1599069 |
0 |
1599069 |
1599069 |
5.55 % |
11/02/2016 |
| MDC Capital LLC |
Emirate Abu Dhabi United Arab Emirates |
0 |
1599069 |
0 |
1599069 |
1599069 |
5.55 % |
11/02/2016 |
| THE GOLDMAN SACHS GROUP, INC. |
Delaware |
0 |
1481266 |
0 |
1481845 |
1481845 |
5.1 % |
10/02/2016 |
| GOLDMAN, SACHS & CO. |
New York |
0 |
1481266 |
0 |
1481845 |
1481845 |
5.1 % |
10/02/2016 |
| Charles B. Johnson |
USA |
4 |
4 |
4 |
4 |
2359225 |
8.1 % |
04/02/2016 |
| Franklin Advisers, Inc. |
California |
2343025 |
0 |
2343025 |
0 |
2343025 |
8.1 % |
04/02/2016 |
| Rupert H. Johnson, Jr. |
USA |
4 |
4 |
4 |
4 |
2359225 |
8.1 % |
04/02/2016 |
| Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
2359225 |
8.1 % |
04/02/2016 |
| BlackRock, Inc. |
Delaware |
1747639 |
0 |
1811628 |
0 |
1811628 |
6.3 % |
28/01/2016 |
| Columbia Wanger Asset Management, LLC |
Delaware |
1564306 |
0 |
1788773 |
0 |
1788773 |
6.2 % |
20/01/2016 |
| Columbia Wanger Asset Management, LLC |
Delaware |
1564306 |
0 |
1788773 |
0 |
1788773 |
6.2 % |
20/01/2016 |
| JPMorgan Chase & Co. |
Delaware |
5400 |
0 |
0 |
0 |
5400 |
0 % |
07/12/2015 |
| MDC Capital LLC |
The Emirate of Abu Dhabi, United Arab Emirates |
0 |
1469122 |
0 |
1469122 |
1469122 |
5.1 % |
11/09/2015 |
| MDC Capital |
Cayman Islands |
0 |
1469122 |
0 |
1469122 |
1469122 |
5.1 % |
11/09/2015 |
| MDC Capital |
Cayman Islands |
0 |
1469122 |
0 |
1469122 |
1469122 |
5.1 % |
11/09/2015 |
| Mubadala Development Company PJSC |
The Emirate of Abu Dhabi, United Arab Emirates |
0 |
1469122 |
0 |
1469122 |
1469122 |
5.1 % |
11/09/2015 |
| Mubadala Development Company PJSC |
The Emirate of Abu Dhabi, United Arab Emirates |
0 |
1469122 |
0 |
1469122 |
1469122 |
5.1 % |
11/09/2015 |
| MDC Capital LLC |
The Emirate of Abu Dhabi, United Arab Emirates |
0 |
1469122 |
0 |
1469122 |
1469122 |
5.1 % |
11/09/2015 |
| Jennison Associates LLC S.S. or |
Delaware |
1197201 |
0 |
0 |
1199265 |
1199265 |
4.2 % |
09/09/2015 |
| Jennison Associates LLC S.S. or |
Delaware |
1197201 |
0 |
0 |
1199265 |
1199265 |
4.2 % |
09/09/2015 |
| Franklin Advisers, Inc. |
California |
2920450 |
0 |
2941650 |
0 |
2941650 |
10.1 % |
09/07/2015 |
| Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
2954950 |
10.1 % |
09/07/2015 |
| Charles B. Johnson |
USA |
4 |
4 |
4 |
4 |
2954950 |
10.1 % |
09/07/2015 |
| Rupert H. Johnson, Jr. |
USA |
4 |
4 |
4 |
4 |
2954950 |
10.1 % |
09/07/2015 |
| OrbiMed Advisors LLC |
Delaware |
0 |
878000 |
0 |
878000 |
878000 |
3.11 % |
17/02/2015 |
| OrbiMed Capital LLC |
Delaware |
0 |
1258200 |
0 |
0 |
1258200 |
4.45 % |
17/02/2015 |
| Samuel D. Isaly |
United States |
0 |
2136200 |
0 |
2136200 |
2136200 |
7.56 % |
17/02/2015 |
| PRIMECAP Management Company |
|
|
|
|
|
3726832 |
13.19 % |
13/02/2015 |
| Next Century Growth Investors, LLC |
Delaware |
0 |
1753841 |
0 |
1753841 |
6.21 |
6.21 % |
13/02/2015 |
| Thomas L. Press |
U.S.A. |
0 |
1753841 |
0 |
1753841 |
6.21 |
6.21 % |
13/02/2015 |
| Jennison Associates LLC : Identification #522069785 |
Delaware |
3075287 |
0 |
0 |
3085827 |
3085827 |
10.9 % |
09/02/2015 |
| Franklin Advisers, Inc. |
California |
2198394 |
0 |
2225594 |
0 |
2225594 |
7.8 % |
09/02/2015 |
| Rupert H. Johnson, Jr. |
USA |
4 |
4 |
4 |
4 |
2308761 |
8.1 % |
09/02/2015 |
| Charles B. Johnson |
USA |
4 |
4 |
4 |
4 |
2308761 |
8.1 % |
09/02/2015 |
| Franklin Resources, Inc. |
Delaware |
4 |
4 |
4 |
4 |
2308761 |
8.1 % |
09/02/2015 |
| JPMorgan Chase & Co. |
Delaware |
2751945 |
4 |
2931594 |
4 |
2931598 |
10.3 % |
08/01/2015 |
| Lord, Abbett & Co. LLC |
|
|
|
|
|
1301858 |
4.67 % |
10/04/2014 |
| PRIMECAP Management Company |
South Lake Ave Pasadena CA |
2522223 |
0 |
3484821 |
0 |
3484821 |
13.61 % |
14/02/2014 |
| Lord, Abbett & Co. LLC |
|
|
|
|
|
1660880 |
6.48 % |
14/02/2014 |
| OrbiMed Advisors LLC |
Delaware |
0 |
189000 |
0 |
189000 |
189000 |
0.74 % |
13/02/2014 |
| Samuel D. Isaly |
United States |
0 |
1446008 |
0 |
1446008 |
1446008 |
5.65 % |
13/02/2014 |
| OrbiMed Capital LLC |
Delaware |
0 |
1257008 |
0 |
0 |
1257008 |
4.91 % |
13/02/2014 |
| Jennison Associates LLC S.S. or |
Delaware |
2690748 |
0 |
0 |
2690748 |
2690748 |
10.5 % |
07/02/2014 |
| Jennison Associates LLC S.S. or |
Delaware |
2690748 |
0 |
0 |
2690748 |
2690748 |
10.5 % |
07/02/2014 |
| Singapore Pte Ltd |
Singapore |
0 |
0 |
0 |
0 |
0 |
0 % |
22/01/2014 |
| Biomedical Sciences Investment Fund Pte Ltd |
Singapore |
0 |
277180 |
0 |
277180 |
277180 |
1.1 % |
22/01/2014 |
| JPMorgan Chase & Co. |
Delaware |
1383948 |
0 |
1453971 |
0 |
1453971 |
5.6 % |
16/01/2014 |
| PRIMECAP Management Company |
225 South Lake Ave., #400, Pasadena, CA 91101 |
2226743 |
0 |
2559209 |
0 |
2559209 |
10.24 % |
05/03/2013 |
| PRIMECAP Management Company |
225 South Lake Ave., #400, Pasadena, CA 91101 |
2226743 |
0 |
2559209 |
0 |
2559209 |
10.24 % |
05/03/2013 |
| s . The TCW Group, Inc., on behalf of the TCW Business Unit |
Nevada |
0 |
498990 |
0 |
501540 |
501540 |
2 % |
14/02/2013 |
| Samuel D. Isaly |
United States |
0 |
1369200 |
0 |
1369200 |
1369200 |
5.48 % |
14/02/2013 |
| OrbiMed Capital LLC |
Delaware |
0 |
1196100 |
0 |
1196100 |
1196100 |
4.79 % |
14/02/2013 |
| OrbiMed Advisors LLC |
Delaware |
0 |
173100 |
0 |
173100 |
173100 |
0.69 % |
14/02/2013 |
| Capital World Investors |
Delaware |
0 |
0 |
0 |
0 |
4 |
0 % |
13/02/2013 |
| Jennison Associates LLC : Identification #522069785 |
Delaware |
3108104 |
0 |
0 |
3108104 |
3108104 |
12.4 % |
12/02/2013 |
| BRIAN G. ATWOOD |
United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
4.21 % |
11/02/2013 |
| Versant Ventures I, LLC |
Delaware United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
4.21 % |
11/02/2013 |
| Versant Affiliates Fund IB, L.P. |
Delaware United States America |
51878 |
0 |
51878 |
0 |
51878 |
0.21 % |
11/02/2013 |
| Versant Affiliates Fund IA, L.P. |
Delaware United States America |
17696 |
0 |
17696 |
0 |
17696 |
0.07 % |
11/02/2013 |
| Versant Side Fund I, L.P. |
Delaware United States America |
20017 |
0 |
20017 |
0 |
20017 |
0.08 % |
11/02/2013 |
| BARBARA N. LUBASH |
United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
4.21 % |
11/02/2013 |
| DONALD B. MILDER |
United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
4.21 % |
11/02/2013 |
| ROSS A. JAFFE, M.D. |
United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
4.21 % |
11/02/2013 |
| WILLIAM J. LINK, Ph.D. |
United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
4.21 % |
11/02/2013 |
| SAMUEL D. COLELLA |
United States America |
49586 |
1050940 |
49586 |
1050940 |
1100526 |
4.4 % |
11/02/2013 |
| Versant Venture Capital I, L.P. |
Delaware United States America |
961349 |
0 |
961349 |
0 |
961349 |
3.85 % |
11/02/2013 |
| REBECCA B. ROBERTSON |
United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
4.21 % |
11/02/2013 |
| JPMorgan Chase & Co. |
Delaware |
1323985 |
0 |
1392385 |
0 |
1392385 |
5.5 % |
24/01/2013 |
| Singapore Pte Ltd |
Singapore |
0 |
110025 |
0 |
110025 |
110025 |
0.4 % |
22/01/2013 |
| Biomedical Sciences Investment Fund Pte Ltd |
Singapore |
0 |
1518097 |
0 |
1518097 |
1518097 |
6 % |
22/01/2013 |
| PRIMECAP Management Company |
|
|
|
|
|
1328900 |
5.32 % |
09/01/2013 |
| Jennison Associates LLC S.S. or I.R.S. Identification No. of Above Person: IRS Identification (formerly |
Delaware |
2795609 |
0 |
0 |
2795609 |
2795609 |
11.2 % |
10/12/2012 |
| Jennison Associates LLC S.S. or I.R.S. Identification No. of Above Person: IRS Identification (formerly |
Delaware |
2795609 |
0 |
0 |
2795609 |
2795609 |
11.2 % |
10/12/2012 |
| DONALD B. MILDER |
United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
5.19 % |
10/02/2012 |
| WILLIAM J. LINK, Ph.D. |
United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
5.19 % |
10/02/2012 |
| ROSS A. JAFFE, M.D. |
United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
5.19 % |
10/02/2012 |
| BARBARA N. LUBASH |
United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
5.19 % |
10/02/2012 |
| REBECCA B. ROBERTSON |
United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
5.19 % |
10/02/2012 |
| Versant Side Fund I, L.P. |
Delaware United States America |
20017 |
0 |
20017 |
0 |
20017 |
0.1 % |
10/02/2012 |
| Versant Venture Capital I, L.P. |
Delaware United States America |
961349 |
0 |
961349 |
0 |
961349 |
4.75 % |
10/02/2012 |
| SAMUEL D. COLELLA |
United States America |
29340 |
1050940 |
29340 |
1050940 |
1080280 |
5.34 % |
10/02/2012 |
| BRIAN G. ATWOOD |
United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
5.19 % |
10/02/2012 |
| Versant Ventures I, LLC |
Delaware United States America |
0 |
1050940 |
0 |
1050940 |
1050940 |
5.19 % |
10/02/2012 |
| Versant Affiliates Fund IB, L.P. |
Delaware United States America |
51878 |
0 |
51878 |
0 |
51878 |
0.26 % |
10/02/2012 |
| Versant Affiliates Fund IA, L.P. |
Delaware United States America |
17696 |
0 |
17696 |
0 |
17696 |
0.09 % |
10/02/2012 |
| Capital World Investors |
Delaware |
1484234 |
0 |
1484234 |
0 |
1484234 |
7.3 % |
10/02/2012 |
| s . The TCW Group, Inc., on behalf of the TCW Business Unit |
Nevada |
0 |
936680 |
0 |
1166895 |
1166895 |
5.8 % |
09/02/2012 |
