BlackRock, Inc. |
Delaware |
1126409 |
0 |
1127922 |
0 |
1127922 |
2.3 % |
12/07/2021 |
BlackRock, Inc. |
Delaware |
3294723 |
0 |
3313971 |
0 |
3313971 |
7.4 % |
29/01/2021 |
BlackRock, Inc. |
Delaware |
2787946 |
0 |
2835590 |
0 |
2835590 |
6.5 % |
05/02/2020 |
BlackRock, Inc. |
Delaware |
2853484 |
0 |
2913245 |
0 |
2913245 |
7 % |
07/02/2019 |
Samurai Investments San Diego LLC |
California |
1750000 |
0 |
1750000 |
0 |
1750000 |
4.1 % |
16/05/2018 |
Hajime Satomi |
Japan |
2217000 |
0 |
2217000 |
0 |
2217000 |
5.3 % |
16/05/2018 |
BlackRock, Inc. |
Delaware |
1672964 |
0 |
1711194 |
0 |
1711194 |
4.7 % |
09/01/2018 |
BlackRock, Inc. |
Delaware |
1937665 |
0 |
1974411 |
0 |
1974411 |
5.7 % |
30/01/2017 |
FMR LLC |
Delaware |
0 |
0 |
1827500 |
0 |
1827500 |
5.663 % |
11/07/2016 |
FMR LLC |
Delaware |
0 |
0 |
1827500 |
0 |
1827500 |
5.663 % |
11/07/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
1827500 |
0 |
1827500 |
5.663 % |
11/07/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
1827500 |
0 |
1827500 |
5.663 % |
11/07/2016 |
FMR LLC |
Delaware |
0 |
0 |
3507800 |
0 |
3507800 |
11.734 % |
10/09/2015 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
3507800 |
0 |
3507800 |
11.734 % |
10/09/2015 |
Abigail P. Johnson |
United States of America |
0 |
0 |
3507800 |
0 |
3507800 |
11.734 % |
10/09/2015 |
Select Biotechnology Portfolio |
Massachusetts |
2489320 |
0 |
0 |
0 |
2489320 |
8.327 % |
10/09/2015 |
Select Biotechnology Portfolio |
Massachusetts |
2489320 |
0 |
0 |
0 |
2489320 |
8.327 % |
10/09/2015 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
3507800 |
0 |
3507800 |
11.734 % |
10/09/2015 |
FMR LLC |
Delaware |
0 |
0 |
3507800 |
0 |
3507800 |
11.734 % |
10/09/2015 |
Abigail P. Johnson |
United States of America |
0 |
0 |
3507800 |
0 |
3507800 |
11.734 % |
10/09/2015 |
Hajime Satomi |
Japan |
2217000 |
0 |
2217000 |
0 |
2217000 |
10 % |
20/05/2013 |
Samurai Investments San Diego LLC |
California |
1750000 |
0 |
1750000 |
0 |
1750000 |
8 % |
20/05/2013 |
Strand Advisors XVI, Inc. |
Delaware |
0 |
843369 |
0 |
843369 |
843369 |
5.2 % |
09/02/2012 |
Pyxis Long/Short Healthcare Fund |
Delaware |
843369 |
0 |
843369 |
0 |
843369 |
5.2 % |
09/02/2012 |
Cummings Bay Capital Management, L.P. |
Delaware |
0 |
913030 |
0 |
913030 |
913030 |
5.6 % |
09/02/2012 |
Cummings Bay Capital Management GP, LLC |
Delaware |
0 |
913030 |
0 |
913030 |
913030 |
5.6 % |
09/02/2012 |
Highland Capital Management Services, Inc. |
Delaware |
0 |
913030 |
0 |
913030 |
913030 |
5.6 % |
09/02/2012 |
James D. Dondero |
United States |
0 |
913030 |
0 |
913030 |
913030 |
5.6 % |
09/02/2012 |
Pyxis Capital, L.P. |
Delaware |
0 |
843369 |
0 |
843369 |
843369 |
5.2 % |
09/02/2012 |
Southpaw Asset Management LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
23/01/2012 |
Howard Golden |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
23/01/2012 |
Southpaw Holdings LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
23/01/2012 |
Southpaw Credit Opportunity Master Fund L.P. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
23/01/2012 |
Kevin Wyman |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
23/01/2012 |
Burlingame Equity Investors Ltd. |
Cayman Islands |
0 |
72826 |
0 |
72826 |
72826 |
0.6 % |
14/02/2011 |
Burlingame Equity Investors II, LP |
Delaware |
0 |
47064 |
0 |
47064 |
47064 |
0.4 % |
14/02/2011 |
Burlingame Special Opportunities III, LP |
Delaware |
0 |
385339 |
0 |
385339 |
385339 |
3 % |
14/02/2011 |
Burlingame Asset Management, LLC |
Delaware |
0 |
908768 |
0 |
908768 |
908768 |
6.8 % |
14/02/2011 |
Blair E. Sanford |
United States |
0 |
908768 |
0 |
908768 |
908768 |
6.8 % |
14/02/2011 |
Burlingame Equity Investors, LP |
Delaware |
0 |
403539 |
0 |
403539 |
403539 |
3.1 % |
14/02/2011 |
Kevin Wyman |
United States |
0 |
956294 |
0 |
956294 |
956294 |
7.1 % |
19/01/2011 |
Southpaw Asset Management LP |
Delaware |
0 |
956294 |
0 |
956294 |
956294 |
7.1 % |
19/01/2011 |
Southpaw Credit Opportunity Master Fund LP |
Cayman Islands |
0 |
873149 |
0 |
873149 |
873149 |
6.6 % |
19/01/2011 |
Southpaw Holdings LLC |
Delaware |
0 |
956294 |
0 |
956294 |
956294 |
7.1 % |
19/01/2011 |
Howard Golden |
United States |
0 |
956294 |
0 |
956294 |
956294 |
7.1 % |
19/01/2011 |
Burlingame Equity Investors, LP |
Delaware |
0 |
468385 |
0 |
468385 |
468385 |
3.7 % |
16/02/2010 |
Burlingame Equity Investors II, LP |
Delaware |
0 |
54628 |
0 |
54628 |
54628 |
0.4 % |
16/02/2010 |
Burlingame Special Opportunities III, LP |
Delaware |
0 |
447336 |
0 |
447336 |
447336 |
3.6 % |
16/02/2010 |
Burlingame Equity Investors |
Cayman Islands |
0 |
84533 |
0 |
84533 |
84533 |
0.7 % |
16/02/2010 |
Blair E. Sanford |
United States |
0 |
1054881 |
0 |
1054881 |
1054881 |
8 % |
16/02/2010 |
Burlingame Asset Management, LLC |
Delaware |
0 |
1054881 |
0 |
1054881 |
1054881 |
8 % |
16/02/2010 |
Southpaw Asset Management LP |
Delaware |
0 |
934525 |
0 |
934525 |
934525 |
7.2 % |
28/12/2009 |
Howard Golden |
United States |
0 |
934525 |
0 |
934525 |
934525 |
7.2 % |
28/12/2009 |
Southpaw Asset Management LP |
Delaware |
0 |
934525 |
0 |
934525 |
934525 |
7.2 % |
28/12/2009 |
Southpaw Holdings LLC |
Delaware |
0 |
934525 |
0 |
934525 |
934525 |
7.2 % |
28/12/2009 |
Southpaw Credit Opportunity Master Fund LP |
Cayman Islands |
0 |
853272 |
0 |
853272 |
853272 |
6.6 % |
28/12/2009 |
Kevin Wyman |
United States |
0 |
934525 |
0 |
934525 |
934525 |
7.2 % |
28/12/2009 |
Southpaw Holdings LLC |
Delaware |
0 |
934525 |
0 |
934525 |
934525 |
7.2 % |
28/12/2009 |
Southpaw Credit Opportunity Master Fund LP |
Cayman Islands |
0 |
853272 |
0 |
853272 |
853272 |
6.6 % |
28/12/2009 |
Kevin Wyman |
United States |
0 |
934525 |
0 |
934525 |
934525 |
7.2 % |
28/12/2009 |
Howard Golden |
United States |
0 |
934525 |
0 |
934525 |
934525 |
7.2 % |
28/12/2009 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
325414 |
0 |
325414 |
325414 |
2.6 % |
24/12/2009 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
224859 |
0 |
224859 |
224859 |
1.8 % |
24/12/2009 |
BVF Investments, L.L.C. |
Delaware |
0 |
821233 |
0 |
821233 |
821233 |
6.3 % |
24/12/2009 |
BVF Inc. |
Delaware |
0 |
1455610 |
0 |
1455610 |
1455610 |
10.7 % |
24/12/2009 |
Mark N. Lampert |
United States |
0 |
1455610 |
0 |
1455610 |
1455610 |
10.7 % |
24/12/2009 |
Investment 10, L.L.C. |
Illinois |
0 |
84102 |
0 |
84102 |
84102 |
0 % |
24/12/2009 |
BVF Partners L.P. |
Delaware |
0 |
1455610 |
0 |
1455610 |
1455610 |
10.7 % |
24/12/2009 |
Mark N. Lampert |
United States |
0 |
1455610 |
0 |
1455610 |
1455610 |
10.7 % |
24/12/2009 |
BVF Inc. |
Delaware |
0 |
1455610 |
0 |
1455610 |
1455610 |
10.7 % |
24/12/2009 |
BVF Partners L.P. |
Delaware |
0 |
1455610 |
0 |
1455610 |
1455610 |
10.7 % |
24/12/2009 |
Investment 10, L.L.C. |
Illinois |
0 |
84102 |
0 |
84102 |
84102 |
0 % |
24/12/2009 |
BVF Investments, L.L.C. |
Delaware |
0 |
821233 |
0 |
821233 |
821233 |
6.3 % |
24/12/2009 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
224859 |
0 |
224859 |
224859 |
1.8 % |
24/12/2009 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
325414 |
0 |
325414 |
325414 |
2.6 % |
24/12/2009 |