Molecular Templates, Inc. MTEM
Trading inactive
| Name of reporting person | Citizenship or organization | Sole voting power | Shared voting power | Sole dispositive power | Shared dispositive power | Amount beneficially owned | Percent of class | Accepted date |
|---|---|---|---|---|---|---|---|---|
| SilverArc Capital Management, LLC | Delaware | 0 | 354608 | 0 | 0 | 354608 | 6.6 % | 14/02/2024 |
| Devesh Gandhi | Massachusetts | 0 | 354608 | 0 | 0 | 354608 | 6.6 % | 14/02/2024 |
| SilverArc Capital Management, LLC | Delaware | 0 | 354608 | 0 | 0 | 354608 | 6.6 % | 14/02/2024 |
| Devesh Gandhi | Delaware | 0 | 354608 | 0 | 0 | 354608 | 6.6 % | 14/02/2024 |
| Laurence W. Lytton | USA | 4142361 | 0 | 4142361 | 0 | 4142361 | 11 % | 20/07/2023 |
| Laurence W. Lytton | USA | 4142361 | 0 | 4142361 | 0 | 4142361 | 11 % | 20/07/2023 |
| Adage Capital Partners, L.P. | Delaware | 0 | 4391489 | 0 | 0 | 4391489 | 5.45 % | 18/07/2023 |
| Adage Capital Management, L.P. | Delaware | 0 | 4391489 | 0 | 0 | 4391489 | 5.45 % | 18/07/2023 |
| Phillip Gross | Delaware | 0 | 4391489 | 0 | 0 | 4391489 | 5.45 % | 18/07/2023 |
| Adage Capital Partners, L.P. | Delaware | 0 | 4391489 | 0 | 0 | 4391489 | 5.45 % | 18/07/2023 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 4391489 | 0 | 0 | 4391489 | 5.45 % | 18/07/2023 |
| Adage Capital Management, L.P. | Delaware | 0 | 4391489 | 0 | 0 | 4391489 | 5.45 % | 18/07/2023 |
| Robert Atchinson | United States | 0 | 4391489 | 0 | 0 | 4391489 | 5.45 % | 18/07/2023 |
| Phillip Gross | United States | 0 | 4391489 | 0 | 0 | 4391489 | 5.45 % | 18/07/2023 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 4391489 | 0 | 0 | 4391489 | 5.45 % | 18/07/2023 |
| Robert Atchinson | Delaware | 0 | 4391489 | 0 | 0 | 4391489 | 5.45 % | 18/07/2023 |
| Parag Shah | Delaware | 0 | 6250860 | 0 | 6250860 | 6250860 | 9.985 % | 26/06/2023 |
| Anup Arora | Delaware | 0 | 6250860 | 0 | 6250860 | 6250860 | 9.985 % | 26/06/2023 |
| K2 HealthVentures Equity Trust LLC | Delaware | 0 | 6250860 | 0 | 6250860 | 6250860 | 9.985 % | 26/06/2023 |
| Parag Shah | Delaware | 0 | 6250860 | 0 | 6250860 | 6250860 | 9.985 % | 26/06/2023 |
| K2 HealthVentures Equity Trust LLC | Delaware | 0 | 6250860 | 0 | 6250860 | 6250860 | 9.985 % | 26/06/2023 |
| Anup Arora | Delaware | 0 | 6250860 | 0 | 6250860 | 6250860 | 9.985 % | 26/06/2023 |
| (1) BlackRock, Inc. | Delaware | 2802403 | 0 | 2814461 | 0 | 2814461 | 4.99 % | 09/03/2022 |
| Millennium Pharmaceuticals, Inc. | Delaware | 0 | 2314659 | 0 | 10 | 2314659 | 4.1 % | 14/09/2021 |
| Takeda Pharma A/S | Denmark | 0 | 0 | 0 | 10 | 0 | 0 % | 14/09/2021 |
| Takeda A/S | Denmark | 0 | 0 | 0 | 10 | 0 | 0 % | 14/09/2021 |
| Takeda Europe Holdings B.V. | Netherlands | 0 | 0 | 0 | 10 | 0 | 0 % | 14/09/2021 |
| Takeda Pharmaceuticals International AG | Switzerland | 0 | 2314659 | 0 | 10 | 2314659 | 4.1 % | 14/09/2021 |
| Takeda Pharmaceutical Company Limited | Japan | 0 | 2314659 | 0 | 10 | 2314659 | 4.1 % | 14/09/2021 |
| Takeda Pharmaceuticals U.S.A., Inc. | Delaware | 0 | 2314659 | 0 | 10 | 2314659 | 4.1 % | 14/09/2021 |
| (1) BlackRock, Inc. | Delaware | 3062818 | 0 | 3078709 | 0 | 3078709 | 6.2 % | 02/02/2021 |
| 10. | Switzerland | 0 | 2161152 | 0 | 2161152 | 2161152 | 5.03 % | 29/01/2020 |
| 2. | Switzerland | 0 | 2161152 | 0 | 2161152 | 2161152 | 5.03 % | 29/01/2020 |
| 2. | Switzerland | 0 | 2161152 | 0 | 2161152 | 2161152 | 5.03 % | 29/01/2020 |
| 10. | Switzerland | 0 | 2161152 | 0 | 2161152 | 2161152 | 5.03 % | 29/01/2020 |
| Biotechnology Value Trading Fund OS LP | United States | 0 | 0 | 0 | 245704 | 245704 | 1 % | 14/02/2019 |
| Biotechnology Value Fund II, L.P. | United States | 0 | 0 | 0 | 1241549 | 1241549 | 3.4 % | 14/02/2019 |
| Biotechnology Value Fund, L.P. | United States | 0 | 0 | 0 | 1576712 | 1576712 | 4.3 % | 14/02/2019 |
| Mark N. Lampert | United States | 0 | 0 | 0 | 3364421 | 3364421 | 9.2 % | 14/02/2019 |
| BVF Inc. | United States | 0 | 0 | 0 | 3364421 | 3364421 | 9.2 % | 14/02/2019 |
| BVF Partners L.P. | United States | 0 | 0 | 0 | 3364421 | 3364421 | 9.2 % | 14/02/2019 |
| BVF Partners OS Ltd. | United States | 0 | 0 | 0 | 245704 | 245704 | 1 % | 14/02/2019 |
| Page 3 of 10 Pages | Delaware | 0 | 13 | 0 | 1497696 | 1497696 | 4.1 % | 06/02/2019 |
| Page 4 of 10 Pages | Delaware | 0 | 13 | 0 | 1497696 | 1497696 | 4.1 % | 06/02/2019 |
| Page 5 of 10 Pages | Delaware | 0 | 13 | 0 | 1497696 | 1497696 | 4.1 % | 06/02/2019 |
| Page 2 of 10 Pages | Delaware | 0 | 13 | 0 | 1497696 | 1497696 | 4.1 % | 06/02/2019 |
| Page 6 of 10 Pages | Delaware | 0 | 13 | 0 | 1497696 | 1497696 | 4.1 % | 06/02/2019 |
| BVF Partners L.P. | Delaware | 0 | 0 | 0 | 2787629 | 2787629 | 7.9 % | 01/10/2018 |
| Biotechnology Value Trading Fund OS LP | Delaware | 0 | 0 | 0 | 197824 | 197824 | 1 % | 01/10/2018 |
| Biotechnology Value Fund II, L.P. | Delaware | 0 | 0 | 0 | 1005325 | 1005325 | 2.9 % | 01/10/2018 |
| Biotechnology Value Fund, L.P. | Delaware | 0 | 0 | 0 | 1329237 | 1329237 | 3.8 % | 01/10/2018 |
| BVF Inc. | Delaware | 0 | 0 | 0 | 2787629 | 2787629 | 7.9 % | 01/10/2018 |
| BVF Partners OS Ltd. | Delaware | 0 | 0 | 0 | 197824 | 197824 | 1 % | 01/10/2018 |
| Biotechnology Value Fund, L.P. | Delaware | 0 | 0 | 0 | 1329237 | 1329237 | 3.8 % | 01/10/2018 |
| BVF Inc. | Delaware | 0 | 0 | 0 | 2787629 | 2787629 | 7.9 % | 01/10/2018 |
| Mark N. Lampert | Delaware | 0 | 0 | 0 | 2787629 | 2787629 | 7.9 % | 01/10/2018 |
| BVF Partners OS Ltd. | Delaware | 0 | 0 | 0 | 197824 | 197824 | 1 % | 01/10/2018 |
| BVF Partners L.P. | Delaware | 0 | 0 | 0 | 2787629 | 2787629 | 7.9 % | 01/10/2018 |
| Mark N. Lampert | Delaware | 0 | 0 | 0 | 2787629 | 2787629 | 7.9 % | 01/10/2018 |
| Biotechnology Value Trading Fund OS LP | Delaware | 0 | 0 | 0 | 197824 | 197824 | 1 % | 01/10/2018 |
| Biotechnology Value Fund II, L.P. | Delaware | 0 | 0 | 0 | 1005325 | 1005325 | 2.9 % | 01/10/2018 |
| 1,975,133 | Delaware | 0 | 1975133 | 0 | 1975133 | 1975133 | 5.6 % | 27/09/2018 |
| 1,975,133 | Delaware | 0 | 1975133 | 0 | 1975133 | 1975133 | 5.6 % | 27/09/2018 |
| 1,975,133 | Delaware | 0 | 1975133 | 0 | 1975133 | 1975133 | 5.6 % | 27/09/2018 |
| 1,975,133 | Delaware | 0 | 1975133 | 0 | 1975133 | 1975133 | 5.6 % | 27/09/2018 |
| 1,975,133 | Delaware | 0 | 1975133 | 0 | 1975133 | 1975133 | 5.6 % | 27/09/2018 |
| 1,975,133 | Delaware | 0 | 1975133 | 0 | 1975133 | 1975133 | 5.6 % | 27/09/2018 |
| of 11 Pages | Delaware | 0 | 1497696 | 0 | 1497696 | 1497696 | 5.57 % | 13/02/2018 |
| of 11 Pages | Delaware | 0 | 1497696 | 0 | 1497696 | 1497696 | 5.57 % | 13/02/2018 |
| of 11 Pages | Delaware | 0 | 1497696 | 0 | 1497696 | 1497696 | 5.57 % | 13/02/2018 |
| of 11 Pages | Delaware | 0 | 1497696 | 0 | 1497696 | 1497696 | 5.57 % | 13/02/2018 |
| of 11 Pages | Delaware | 0 | 1497696 | 0 | 1497696 | 1497696 | 5.57 % | 13/02/2018 |
| of 11 Pages | Delaware | 0 | 1497696 | 0 | 1497696 | 1497696 | 5.57 % | 13/02/2018 |
| of 11 Pages | Delaware | 0 | 1497696 | 0 | 1497696 | 1497696 | 5.57 % | 13/02/2018 |
| of 11 Pages | Delaware | 0 | 1497696 | 0 | 1497696 | 1497696 | 5.57 % | 13/02/2018 |
| of 11 Pages | Delaware | 0 | 1497696 | 0 | 1497696 | 1497696 | 5.57 % | 13/02/2018 |
| of 11 Pages | Delaware | 0 | 1497696 | 0 | 1497696 | 1497696 | 5.57 % | 13/02/2018 |
| of 11 Pages | Delaware | 0 | 1497696 | 0 | 1497696 | 1497696 | 5.57 % | 13/02/2018 |
| of 11 Pages | Delaware | 0 | 1497696 | 0 | 1497696 | 1497696 | 5.57 % | 13/02/2018 |
| Longitude Capital Partners III, LLC | Delaware | 0 | 4344802 | 0 | 4344802 | 4344802 | 15.3 % | 18/09/2017 |
| David Hirsch | United States of America | 0 | 4344802 | 0 | 4344802 | 4344802 | 15.3 % | 18/09/2017 |
| Longitude Venture Partners III, L.P. | Delaware | 0 | 4344802 | 0 | 4344802 | 4344802 | 15.3 % | 18/09/2017 |
| Juliet Tammenoms Bakker | United States of America | 0 | 4344802 | 0 | 4344802 | 4344802 | 15.3 % | 18/09/2017 |
| Patrick G. Enright | United States of America | 0 | 4344802 | 0 | 4344802 | 4344802 | 15.3 % | 18/09/2017 |
| Tax ID # 57-1156902 | State of Delaware | 0 | 0 | 0 | 0 | 7093802 | 9.91 % | 06/02/2017 |
| Tax ID # 57-1156902 | State of Delaware | 0 | 0 | 0 | 0 | 7093802 | 9.91 % | 06/02/2017 |
| Heights Capital Management, Inc. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 12/02/2016 |
| Capital Ventures International | Cayman Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 12/02/2016 |
| 13G | Cayman Islands | 0 | 4150000 | 0 | 4150000 | 4150000 | 5.9 % | 20/02/2015 |
| Capital Ventures International | Cayman Islands | 0 | 4150000 | 0 | 0 | 4150000 | 5.9 % | 20/02/2015 |
| 13G | Delaware | 0 | 4150000 | 0 | 4150000 | 4150000 | 5.9 % | 20/02/2015 |
| Heights Capital Management, Inc. | Cayman Islands | 0 | 4150000 | 0 | 0 | 4150000 | 5.9 % | 20/02/2015 |
| Rhodora J. Donahue | Citizenship or place of Organization | 0 | 4041793 | 0 | 4041793 | 4041793 | 6.44 % | 11/02/2015 |
| Federated Investors, Inc. | Citizenship or place of Organization | 4041793 | 0 | 4041793 | 0 | 4041793 | 6.44 % | 11/02/2015 |
| Voting Shares Irrevocable Trust | Citizenship or place of Organization | 4041793 | 0 | 4041793 | 0 | 4041793 | 6.44 % | 11/02/2015 |
| John F. Donahue | Citizenship or place of Organization | 0 | 4041793 | 0 | 4041793 | 4041793 | 6.44 % | 11/02/2015 |
| J. Christopher Donahue | Citizenship or place of Organization | 0 | 4041793 | 0 | 4041793 | 4041793 | 6.44 % | 11/02/2015 |
| (1) BlackRock, Inc. | Delaware | 3807802 | 0 | 3885229 | 0 | 3885229 | 6.2 % | 30/01/2015 |
| (1) BlackRock, Inc. | Delaware | 3773062 | 0 | 3849991 | 0 | 3849991 | 6.5 % | 30/01/2014 |
| 13-4093645 | Delaware | 2912391 | 0 | 2912391 | 0 | 2912391 | 5.2 % | 04/02/2013 |
| Julian C. Baker | United States | 2912391 | 0 | 2912391 | 0 | 2912391 | 5.2 % | 04/02/2013 |
| Felix J. Baker | United States | 2912391 | 0 | 2912391 | 0 | 2912391 | 5.2 % | 04/02/2013 |
| Felix J. Baker | Delaware | 2912391 | 0 | 2912391 | 0 | 2912391 | 5.2 % | 04/02/2013 |
| 13-4093645 | Delaware | 2912391 | 0 | 2912391 | 0 | 2912391 | 5.2 % | 04/02/2013 |
| Julian C. Baker | Delaware | 2912391 | 0 | 2912391 | 0 | 2912391 | 5.2 % | 04/02/2013 |
| BARCLAYS GLOBAL INVESTORS, NA. | Delaware | 3280622 | 0 | 3387452 | 0 | 1584098 | 2.51 % | 01/02/2013 |
| FMR LLC | Delaware | 234110 | 0 | 7464291 | 0 | 7464291 | 14.99 % | 12/03/2012 |
| Edward C. Johnson 3d | Delaware | 0 | 0 | 7464291 | 0 | 7464291 | 14.99 % | 12/03/2012 |
| Edward C. Johnson 3d | Delaware | 0 | 0 | 7464291 | 0 | 7464291 | 14.99 % | 12/03/2012 |
| FMR LLC | Delaware | 234110 | 0 | 7464291 | 0 | 7464291 | 14.99 % | 12/03/2012 |
| FRAZIER HEALTHCARE VI, L.P. | Delaware | 1951632 | 0 | 1951632 | 0 | 1951632 | 3.8 % | 23/02/2012 |
| FHM VI, L.L.C. | Delaware | 1951632 | 0 | 1951632 | 0 | 1951632 | 3.8 % | 23/02/2012 |
| FHM VI, L.P. | Delaware | 1951632 | 0 | 1951632 | 0 | 1951632 | 3.8 % | 23/02/2012 |
| Wilfred Jaeger | Canadian Citizen | 50833 | 3245212 | 50833 | 3245212 | 3296045 | 6.6 % | 13/02/2012 |
| Three Arch Management III, L.L.C. | Delaware | 3245212 | 3245212 | 3245212 | 3245212 | 3245212 | 6.5 % | 13/02/2012 |
| Three Arch Partners III, L.P. (“TAP III”) | Delaware | 3079649 | 3079649 | 3079649 | 3079649 | 3079649 | 6.2 % | 13/02/2012 |
| Three Arch Associates III, L.P. (“TAA III”) | Delaware | 165563 | 165563 | 165563 | 165563 | 165563 | 0.3 % | 13/02/2012 |
| Mark Wan | U.S. Citizen | 0 | 3245212 | 0 | 3245212 | 3245212 | 6.5 % | 13/02/2012 |
| Sutter Hill Entrepreneurs Fund (AI), L.P. 94-3338942 | USA | 3960 | 0 | 3960 | 0 | 3960 | 0 % | 09/02/2012 |
| Sutter Hill Entrepreneurs Fund (QP), L.P. 94-3338941 | USA | 10028 | 0 | 10028 | 0 | 10028 | 0 % | 09/02/2012 |
| David L. Anderson | USA | 150558 | 5468590 | 150558 | 0 | 5619148 | 11.1 % | 09/02/2012 |
| G. Leonard Baker, Jr. | USA | 237791 | 5468590 | 237791 | 0 | 5706381 | 11.3 % | 09/02/2012 |
| William H. Younger, Jr. | USA | 321958 | 5468590 | 321958 | 0 | 5790548 | 11.4 % | 09/02/2012 |
| Tench Coxe | USA | 920933 | 5468590 | 920933 | 0 | 6389523 | 12.6 % | 09/02/2012 |
| Gregory P. Sands | USA | 169999 | 5468590 | 169999 | 0 | 5638589 | 11.1 % | 09/02/2012 |
| James C. Gaither | USA | 83958 | 5468590 | 83958 | 0 | 5552548 | 11 % | 09/02/2012 |
| James N. White | USA | 310884 | 5468590 | 310884 | 0 | 5779474 | 11.4 % | 09/02/2012 |
| Jeffrey W. Bird | USA | 328538 | 5468590 | 328538 | 0 | 5797128 | 11.4 % | 09/02/2012 |
| David E. Sweet | USA | 58782 | 5468590 | 58782 | 0 | 5527372 | 10.9 % | 09/02/2012 |
| Andrew T. Sheehan | USA | 90743 | 5468590 | 90743 | 0 | 5559333 | 11 % | 09/02/2012 |
| Michael L. Speiser | USA | 13746 | 5468590 | 13746 | 0 | 5482336 | 10.8 % | 09/02/2012 |
| Sutter Hill Ventures, A California Limited Partnership 77-0287059 | USA | 5454602 | 0 | 5454602 | 0 | 5454602 | 10.8 % | 09/02/2012 |
| FHM VI, L.L.C. | Delaware | 6530713 | 0 | 6530713 | 0 | 6530713 | 12.8 % | 08/02/2012 |
| FRAZIER HEALTHCARE VI, L.P. | Delaware | 6530713 | 0 | 6530713 | 0 | 6530713 | 12.8 % | 08/02/2012 |
| FHM VI, L.P. | Delaware | 6530713 | 0 | 6530713 | 0 | 6530713 | 12.8 % | 08/02/2012 |
| Alta BioPharma Partners III GmbH & Co. Beteiligungs KG | Reporting | 212298 | 0 | 212298 | 0 | 212298 | 0.4 % | 10/01/2012 |
| Alta BioPharma Management III, LLC | Reporting | 0 | 3373426 | 0 | 3373426 | 3373426 | 6.7 % | 10/01/2012 |
| Edward Penhoet | Reporting | 0 | 3451328 | 0 | 3451328 | 3451328 | 6.9 % | 10/01/2012 |
| Edward Hurwitz | Reporting | 0 | 3451328 | 0 | 3451328 | 3451328 | 6.9 % | 10/01/2012 |
| Alta Embarcadero BioPharma Partners III, LLC | Reporting | 77902 | 0 | 77902 | 0 | 77902 | 0.2 % | 10/01/2012 |
| Farah Champsi | Reporting | 0 | 3451328 | 0 | 3451328 | 3451328 | 6.9 % | 10/01/2012 |
| Alta BioPharma Partners III, L.P. | Reporting | 3161128 | 0 | 3161128 | 0 | 3161128 | 6.3 % | 10/01/2012 |
| Lawlor | States | 0 | 4257775 | 0 | 0 | 4257775 | 12.2 % | 10/02/2010 |
| Partners VIII, LLC | States | 0 | 4257775 | 0 | 0 | 4257775 | 12.2 % | 10/02/2010 |
| Ventures VIII, L.P. | States | 0 | 4257775 | 0 | 0 | 4257775 | 12.2 % | 10/02/2010 |
| Partners VIII, L.P. | States | 0 | 4257775 | 0 | 0 | 4257775 | 12.2 % | 10/02/2010 |
| H. Cavanaugh, Ph.D. | States | 0 | 4257775 | 0 | 0 | 4257775 | 12.2 % | 10/02/2010 |
| Mirabelli, Ph.D. | States | 0 | 4257775 | 0 | 0 | 4257775 | 12.2 % | 10/02/2010 |
| R. Werner | States | 0 | 4257775 | 0 | 0 | 4257775 | 12.2 % | 10/02/2010 |
| W. Littlechild | States | 0 | 4257775 | 0 | 0 | 4257775 | 12.2 % | 10/02/2010 |
| FRAZIER HEALTHCARE VI, L.P. | Delaware | 0 | 5497381 | 0 | 5497381 | 5497381 | 15.7 % | 07/10/2009 |
| FHM VI, L.L.C. | Delaware | 0 | 5497381 | 0 | 5497381 | 5497381 | 15.7 % | 07/10/2009 |
| FHM VI, L.P. | Delaware | 0 | 5497381 | 0 | 5497381 | 5497381 | 15.7 % | 07/10/2009 |
| Baker | States | 0 | 1521401 | 0 | 0 | 1521401 | 9.9 % | 17/02/2009 |
| Baker | States | 0 | 1521401 | 0 | 0 | 1521401 | 9.9 % | 17/02/2009 |
| CAPITAL MANAGEMENT, LLC | DELAWARE | 0 | 1399877 | 0 | 0 | 1399877 | 9.2 % | 08/09/2008 |
| CAPITAL PARTNERS, LP | DELAWARE | 0 | 1399877 | 0 | 0 | 1399877 | 9.2 % | 08/09/2008 |
| C. TANG | STATES | 23231 | 1479415 | 23231 | 0 | 1520603 | 9.99 % | 08/09/2008 |
| Christopher Mirabelli, Ph.D. | United States | 0 | 2058823 | 0 | 0 | 2058823 | 13.03 % | 08/09/2008 |
| HealthCare Ventures VIII, L.P. | United States | 0 | 2058823 | 0 | 0 | 2058823 | 13.03 % | 08/09/2008 |
| Harold R. Werner | United States | 0 | 2058823 | 0 | 0 | 2058823 | 13.03 % | 08/09/2008 |
| John W. Littlechild | United States | 0 | 2058823 | 0 | 0 | 2058823 | 13.03 % | 08/09/2008 |
| HealthCare Partners VIII, L.P. | United States | 0 | 2058823 | 0 | 0 | 2058823 | 13.03 % | 08/09/2008 |
| Augustine Lawlor | United States | 0 | 2058823 | 0 | 0 | 2058823 | 13.03 % | 08/09/2008 |
| HealthCare Partners VIII, LLC | United States | 0 | 2058823 | 0 | 0 | 2058823 | 13.03 % | 08/09/2008 |
| James H. Cavanaugh, Ph.D. | United States | 0 | 2058823 | 0 | 0 | 2058823 | 13.03 % | 08/09/2008 |
| Alta BioPharma Partners III GmbH & Co. Beteiligungs KG | Germany | 107738 | 0 | 107738 | 107738 | 107738 | 0.7 % | 05/09/2008 |
| Alta BioPharma Partners III, L.P. | Delaware | 1604234 | 0 | 1604234 | 1604234 | 1604234 | 10.2 % | 05/09/2008 |
| Edward Hurwitz | United States | 0 | 1751506 | 0 | 1751506 | 1751506 | 11.2 % | 05/09/2008 |
| Farah Champsi | United States | 0 | 1751506 | 0 | 1751506 | 1751506 | 11.2 % | 05/09/2008 |
| Edward Penhoet | United States | 0 | 1751506 | 0 | 1751506 | 1751506 | 11.2 % | 05/09/2008 |
| Alix Marduel | United States | 0 | 1751506 | 0 | 1751506 | 1751506 | 11.2 % | 05/09/2008 |
| Jean Deleage | United States | 0 | 1751506 | 0 | 1751506 | 1751506 | 11.2 % | 05/09/2008 |
| Alta Embarcadero BioPharma Partners III, LLC | California | 39534 | 0 | 39534 | 39534 | 39534 | 0.3 % | 05/09/2008 |
| Alta BioPharma Management III, LLC | Delaware | 0 | 1711972 | 0 | 1711972 | 1711972 | 10.9 % | 05/09/2008 |
| James H. Simons | United States | 1990528 | 0 | 1990528 | 0 | 1990528 | 5.33 % | 13/02/2008 |
| 26-0385758 | Delaware | 1990528 | 0 | 1990528 | 0 | 1990528 | 5.33 % | 13/02/2008 |
| Three Arch Management III, L.L.C. (“TAM III”) | Delaware | 2440202 | 0 | 2440202 | 0 | 2440202 | 6.5 % | 11/02/2008 |
| Three Arch Associates III, L.P. (“TAA III”) | Delaware | 124471 | 0 | 124471 | 0 | 124471 | 0.3 % | 11/02/2008 |
| Mark A. Wan | USA | 0 | 2440202 | 0 | 2440202 | 2440202 | 6.5 % | 11/02/2008 |
| Three Arch Partners III, L.P. (“TAP III”) | Delaware | 2315731 | 0 | 2315731 | 0 | 2315731 | 6.2 % | 11/02/2008 |
| Barclay Nicholson | USA | 0 | 2440202 | 0 | 2440202 | 2440202 | 6.5 % | 11/02/2008 |
| Wilfred E. Jaeger | Canada | 41250 | 2440202 | 41250 | 2440202 | 2481452 | 6.6 % | 11/02/2008 |
| J. Baker | States | 0 | 3249959 | 0 | 0 | 3249959 | 8.7 % | 05/01/2007 |
| C. Baker | States | 0 | 3249959 | 0 | 0 | 3249959 | 8.7 % | 05/01/2007 |
| FMR Corp. | Delaware | 0 | 0 | 1733757 | 0 | 1733757 | 4.65 % | 10/08/2006 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 1733757 | 0 | 1733757 | 4.65 % | 10/08/2006 |
| TANG CAPITAL PARTNERS, LP | DELAWARE | 0 | 2150000 | 0 | 0 | 2150000 | 5.77 % | 27/07/2006 |
| TANG CAPITAL MANAGEMENT, LLC | DELAWARE | 0 | 2150000 | 0 | 0 | 2150000 | 5.77 % | 27/07/2006 |
| KEVIN C. TANG | UNITED STATES | 0 | 2150000 | 0 | 0 | 2150000 | 5.77 % | 27/07/2006 |
| FMR Corp. | Delaware | 0 | 0 | 2535156 | 0 | 2535156 | 6.807 % | 14/02/2006 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 2535156 | 0 | 2535156 | 6.807 % | 14/02/2006 |
| Sofinnova Venture Principals V, LP ("SVPr V") | Delaware | 50321 | 0 | 50321 | 0 | 50321 | 0.1 % | 14/02/2006 |
| Sofinnova Venture Partners V, L.P. ("SVP V") | Delaware | 0 | 2005 | 3281905 | 0 | 3281905 | 8.8 % | 14/02/2006 |
| Sofinnova Management V 2005 L.L.C. ("SMV 2005") | Delaware | 0 | 3281905 | 0 | 3281905 | 3281905 | 8.8 % | 14/02/2006 |
| Tax ID Number: | U.S. Citizen | 11250 | 0 | 11250 | 3440200 | 3451450 | 9.3 % | 14/02/2006 |
| Sofinnova Venture Affiliates V, L.P. ("SVA V") | Delaware | 107974 | 0 | 107974 | 0 | 107974 | 0.3 % | 14/02/2006 |
| Tax ID Number: | U.S. Citizen | 0 | 0 | 0 | 3440200 | 3440200 | 9.2 % | 14/02/2006 |
| Sofinnova Management V, L.L.C. ("SM V") | Delaware | 0 | 3281905 | 158295 | 0 | 3440200 | 9.2 % | 14/02/2006 |
| Tax ID Number: | U.S. Citizen | 0 | 0 | 0 | 3440200 | 3440200 | 9.2 % | 14/02/2006 |
| 22-3764772 | Delaware | 0 | 3248605 | 0 | 3248605 | 3248605 | 8.7 % | 13/02/2006 |
| Alain Schreiber | United States | 0 | 3385022 | 0 | 3385022 | 3385022 | 9.1 % | 13/02/2006 |
| 22-3784567 | Delaware | 0 | 136417 | 0 | 136417 | 136417 | 0.4 % | 13/02/2006 |
| 22-3764735 | Delaware | 0 | 3385022 | 0 | 3385022 | 3385022 | 9.1 % | 13/02/2006 |
| Jay Moorin | United States | 0 | 3385022 | 0 | 3385022 | 3385022 | 9.1 % | 13/02/2006 |