Peter Kolchinsky |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
RA Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
Rajeev Shah |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2024 |
Citadel Advisors LLC |
Delaware |
0 |
5625000 |
0 |
5625000 |
5625000 |
3 % |
14/02/2024 |
Citadel Securities Group LP |
Delaware |
0 |
10132 |
0 |
10132 |
10132 |
0 % |
14/02/2024 |
Citadel Securities LLC |
Delaware |
0 |
10132 |
0 |
10132 |
10132 |
0 % |
14/02/2024 |
Citadel GP LLC |
Delaware |
0 |
5625000 |
0 |
5625000 |
5625000 |
3 % |
14/02/2024 |
Citadel Advisors Holdings LP |
Delaware |
0 |
5625000 |
0 |
5625000 |
5625000 |
3 % |
14/02/2024 |
Kenneth Griffin |
U.S. Citizen |
0 |
5635132 |
0 |
5635132 |
5635132 |
3 % |
14/02/2024 |
Citadel Securities GP LLC |
Delaware |
0 |
10132 |
0 |
10132 |
10132 |
0 % |
14/02/2024 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
18700000 |
0 |
18700000 |
18700000 |
9.8 % |
17/08/2023 |
Peter Kolchinsky |
United States of America |
0 |
18700000 |
0 |
18700000 |
18700000 |
9.8 % |
17/08/2023 |
RA Capital Management, L.P. |
Delaware |
0 |
18700000 |
0 |
18700000 |
18700000 |
9.8 % |
17/08/2023 |
Rajeev Shah |
United States of America |
0 |
18700000 |
0 |
18700000 |
18700000 |
9.8 % |
17/08/2023 |
Invesco Ltd. |
Bermuda |
5535430 |
0 |
5535430 |
0 |
5535430 |
2.9 % |
10/07/2023 |
The Vanguard Group |
Pennsylvania For |
0 |
0 |
11987637 |
68550 |
12056187 |
6.37 % |
10/07/2023 |
BlackRock, Inc. |
Delaware |
7807123 |
0 |
8604322 |
0 |
8604322 |
4.5 % |
07/07/2023 |
PRIMECAP Management Company |
E Colorado Blvd th Floor Pasadena CA |
8106976 |
0 |
8149876 |
0 |
8149876 |
4.31 % |
07/07/2023 |
PRIMECAP Management Company |
E Colorado Blvd th Floor Pasadena CA |
8106976 |
0 |
8149876 |
0 |
8149876 |
4.31 % |
07/07/2023 |
Citadel Securities LLC |
Delaware |
0 |
199500 |
0 |
0 |
6 |
0.1 % |
03/07/2023 |
Kenneth Griffin |
US |
0 |
9729752 |
0 |
0 |
6 |
5.1 % |
03/07/2023 |
Citadel Securities GP LLC |
Delaware |
0 |
2229752 |
0 |
0 |
6 |
1.2 % |
03/07/2023 |
Citadel Securities Group LP |
Delaware |
0 |
2229752 |
0 |
0 |
6 |
1.2 % |
03/07/2023 |
Citadel GP LLC |
Delaware |
0 |
7500000 |
0 |
0 |
6 |
4 % |
03/07/2023 |
Citadel Advisors Holdings LP |
Delaware |
0 |
7500000 |
0 |
0 |
6 |
4 % |
03/07/2023 |
Citadel Advisors LLC |
Delaware |
0 |
7500000 |
0 |
0 |
6 |
4 % |
03/07/2023 |
Kenneth Griffin |
US |
0 |
9729752 |
0 |
0 |
6 |
5.1 % |
03/07/2023 |
Citadel Securities GP LLC |
Delaware |
0 |
2229752 |
0 |
0 |
6 |
1.2 % |
03/07/2023 |
Citadel Securities Group LP |
Delaware |
0 |
2229752 |
0 |
0 |
6 |
1.2 % |
03/07/2023 |
Citadel Securities LLC |
Delaware |
0 |
199500 |
0 |
0 |
6 |
0.1 % |
03/07/2023 |
Citadel GP LLC |
Delaware |
0 |
7500000 |
0 |
0 |
6 |
4 % |
03/07/2023 |
Citadel Advisors Holdings LP |
Delaware |
0 |
7500000 |
0 |
0 |
6 |
4 % |
03/07/2023 |
Citadel Advisors LLC |
Delaware |
0 |
7500000 |
0 |
0 |
6 |
4 % |
03/07/2023 |
BlackRock, Inc. |
Delaware |
17170055 |
0 |
18300674 |
0 |
18300674 |
9.7 % |
05/05/2023 |
David Kroin |
United States |
0 |
12302237 |
0 |
12302237 |
0 |
6.5 % |
14/04/2023 |
Deep Track Capital, LP |
Delaware |
0 |
12302237 |
0 |
12302237 |
0 |
6.5 % |
14/04/2023 |
Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
12302237 |
0 |
12302237 |
0 |
6.5 % |
14/04/2023 |
David Kroin |
United States |
0 |
12302237 |
0 |
12302237 |
0 |
6.5 % |
14/04/2023 |
Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
12302237 |
0 |
12302237 |
0 |
6.5 % |
14/04/2023 |
Deep Track Capital, LP |
Delaware |
0 |
12302237 |
0 |
12302237 |
0 |
6.5 % |
14/04/2023 |
The Vanguard Group |
Pennsylvania For |
0 |
121216 |
22776382 |
289393 |
23065775 |
12.27 % |
09/02/2023 |
Invesco Ltd. |
Bermuda |
37248887 |
0 |
37327473 |
0 |
37327473 |
19.9 % |
02/02/2023 |
BlackRock, Inc. |
Delaware |
34751757 |
0 |
35928093 |
0 |
35928093 |
19.1 % |
23/01/2023 |
Invesco Ltd. |
Bermuda |
36834908 |
0 |
36891494 |
0 |
36891494 |
20 % |
11/02/2022 |
BlackRock, Inc. |
Delaware |
25722192 |
0 |
26671803 |
0 |
26671803 |
14.5 % |
27/01/2022 |
BlackRock, Inc. |
Delaware |
25742431 |
0 |
26671803 |
0 |
26671803 |
14.5 % |
25/01/2022 |
The Vanguard Group |
Pennsylvania |
0 |
85766 |
18260705 |
251206 |
18511911 |
10.03 % |
10/01/2022 |
The Vanguard Group |
Pennsylvania |
0 |
85766 |
18260705 |
251206 |
18511911 |
10.03 % |
10/01/2022 |
FMR LLC |
Delaware |
2611477 |
0 |
9465808 |
0 |
9465808 |
5.128 % |
10/12/2021 |
Abigail P. Johnson |
United States of America |
0 |
0 |
9465808 |
0 |
9465808 |
5.128 % |
10/12/2021 |
FMR LLC |
Delaware |
2611477 |
0 |
9465808 |
0 |
9465808 |
5.128 % |
10/12/2021 |
Abigail P. Johnson |
United States of America |
0 |
0 |
9465808 |
0 |
9465808 |
5.128 % |
10/12/2021 |
Invesco Ltd. |
Bermuda |
35350075 |
0 |
35456949 |
0 |
35456949 |
19.8 % |
12/02/2021 |
The Vanguard Group |
Pennsylvania |
0 |
117151 |
16010499 |
262086 |
16272585 |
9.07 % |
10/02/2021 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
13392612 |
0 |
13392612 |
13392612 |
7.47 % |
04/02/2021 |
Wellington Management Group LLP |
Massachusetts |
0 |
13392612 |
0 |
13392612 |
13392612 |
7.47 % |
04/02/2021 |
Wellington Management Company LLP |
Delaware |
0 |
13392612 |
0 |
13392612 |
13392612 |
7.47 % |
04/02/2021 |
Wellington Management Group LLP |
Massachusetts |
0 |
13392612 |
0 |
13392612 |
13392612 |
7.47 % |
04/02/2021 |
Wellington Group Holdings LLP |
Delaware |
0 |
13392612 |
0 |
13392612 |
13392612 |
7.47 % |
04/02/2021 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
13392612 |
0 |
13392612 |
13392612 |
7.47 % |
04/02/2021 |
Wellington Management Company LLP |
Delaware |
0 |
13392612 |
0 |
13392612 |
13392612 |
7.47 % |
04/02/2021 |
Wellington Group Holdings LLP |
Delaware |
0 |
13392612 |
0 |
13392612 |
13392612 |
7.47 % |
04/02/2021 |
BlackRock, Inc. |
Delaware |
17797064 |
0 |
18378080 |
0 |
18378080 |
10.2 % |
26/01/2021 |
Abigail P. Johnson |
United States of America |
0 |
0 |
18698403 |
0 |
18698403 |
10.53 % |
10/03/2020 |
FMR LLC |
Delaware |
4181758 |
0 |
18698403 |
0 |
18698403 |
10.53 % |
10/03/2020 |
FMR LLC |
Delaware |
4181758 |
0 |
18698403 |
0 |
18698403 |
10.53 % |
10/03/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
18698403 |
0 |
18698403 |
10.53 % |
10/03/2020 |
PRIMECAP Management Company |
|
|
|
|
|
20080348 |
11.41 % |
12/02/2020 |
The Vanguard Group |
Pennsylvania |
89450 |
31640 |
16058378 |
99233 |
16157611 |
9.18 % |
12/02/2020 |
Invesco Ltd. |
Bermuda |
31629134 |
0 |
31629134 |
0 |
31629134 |
18 % |
07/02/2020 |
FMR LLC |
Delaware |
3873087 |
0 |
14938026 |
0 |
14938026 |
8.491 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
14938026 |
0 |
14938026 |
8.491 % |
07/02/2020 |
FMR LLC |
Delaware |
3873087 |
0 |
14938026 |
0 |
14938026 |
8.491 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
14938026 |
0 |
14938026 |
8.491 % |
07/02/2020 |
BlackRock, Inc. |
Delaware |
17766330 |
0 |
18417535 |
0 |
18417535 |
10.5 % |
04/02/2020 |
Wellington Management Company LLP |
Delaware |
0 |
15692729 |
0 |
15809703 |
15809703 |
8.99 % |
27/01/2020 |
Wellington Group Holdings LLP |
Delaware |
0 |
15900223 |
0 |
16198179 |
16198179 |
9.21 % |
27/01/2020 |
Wellington Management Group LLP |
Massachusetts |
0 |
15900223 |
0 |
16198179 |
16198179 |
9.21 % |
27/01/2020 |
Wellington Management Company LLP |
Delaware |
0 |
15692729 |
0 |
15809703 |
15809703 |
8.99 % |
27/01/2020 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
15900223 |
0 |
16198179 |
16198179 |
9.21 % |
27/01/2020 |
Wellington Group Holdings LLP |
Delaware |
0 |
15900223 |
0 |
16198179 |
16198179 |
9.21 % |
27/01/2020 |
Wellington Management Group LLP |
Massachusetts |
0 |
15900223 |
0 |
16198179 |
16198179 |
9.21 % |
27/01/2020 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
15900223 |
0 |
16198179 |
16198179 |
9.21 % |
27/01/2020 |
BlackRock, Inc. |
Delaware |
17719245 |
0 |
18726518 |
0 |
18726518 |
10.7 % |
08/11/2019 |
Invesco Ltd. |
Bermuda |
34643386 |
0 |
34643386 |
0 |
34643386 |
19.8 % |
10/10/2019 |
FMR LLC |
Delaware |
4509186 |
0 |
17164317 |
0 |
17164317 |
9.847 % |
12/08/2019 |
Abigail P. Johnson |
United States of America |
0 |
0 |
17164317 |
0 |
17164317 |
9.847 % |
12/08/2019 |
Abigail P. Johnson |
United States of America |
0 |
0 |
17164317 |
0 |
17164317 |
9.847 % |
12/08/2019 |
FMR LLC |
Delaware |
4509186 |
0 |
17164317 |
0 |
17164317 |
9.847 % |
12/08/2019 |
Invesco Ltd. |
Bermuda |
21984578 |
0 |
21984578 |
0 |
21984578 |
12.6 % |
10/06/2019 |
The Vanguard Group |
Pennsylvania |
208599 |
36535 |
18068697 |
235834 |
18304531 |
10.57 % |
11/02/2019 |
PRIMECAP Management Company |
|
|
|
|
|
19400022 |
11.21 % |
08/02/2019 |
BlackRock, Inc. |
Delaware |
11786883 |
0 |
12979178 |
0 |
12979178 |
7.5 % |
06/02/2019 |
OppenheimerFunds, Inc. |
Colorado |
0 |
17302925 |
0 |
17302925 |
17302925 |
10 % |
11/01/2019 |
OppenheimerFunds, Inc. |
Colorado |
0 |
17302925 |
0 |
17302925 |
17302925 |
10 % |
11/01/2019 |
BlackRock, Inc. |
Delaware |
11379475 |
0 |
12666059 |
0 |
12666059 |
7.4 % |
10/07/2018 |
The Vanguard Group |
Pennsylvania |
393418 |
22121 |
16827048 |
402273 |
17229321 |
10.7 % |
10/04/2018 |
The Vanguard Group |
Pennsylvania |
393418 |
22121 |
16827048 |
402273 |
17229321 |
10.7 % |
10/04/2018 |
Abigail P. Johnson |
United States of America |
0 |
0 |
19690476 |
0 |
19690476 |
12.276 % |
12/03/2018 |
FMR LLC |
Delaware |
2629172 |
0 |
19690476 |
0 |
19690476 |
12.276 % |
12/03/2018 |
Abigail P. Johnson |
United States of America |
0 |
0 |
19690476 |
0 |
19690476 |
12.276 % |
12/03/2018 |
FMR LLC |
Delaware |
2629172 |
0 |
19690476 |
0 |
19690476 |
12.276 % |
12/03/2018 |
PRIMECAP Management Company |
|
|
|
|
|
22357522 |
14.2 % |
27/02/2018 |
The Vanguard Group |
Pennsylvania |
291434 |
22121 |
14511418 |
300889 |
14812307 |
9.4 % |
09/02/2018 |
OppenheimerFunds, Inc. Identification No: |
Colorado |
0 |
14604569 |
0 |
14604569 |
14604569 |
9.27 % |
06/02/2018 |
OppenheimerFunds, Inc. Identification No: |
Colorado |
0 |
14604569 |
0 |
14604569 |
14604569 |
9.27 % |
06/02/2018 |
BlackRock, Inc. |
Delaware |
21105291 |
0 |
21431388 |
0 |
21431388 |
13.6 % |
19/01/2018 |
Oppenheimer Global Opportunities Fund |
Delaware |
0 |
14600000 |
0 |
14600000 |
14600000 |
9.27 % |
08/12/2017 |
Oppenheimer Global Opportunities Fund |
Delaware |
0 |
14600000 |
0 |
14600000 |
14600000 |
9.27 % |
08/12/2017 |
OppenheimerFunds, Inc. |
Colorado |
0 |
15094639 |
0 |
15094639 |
15094639 |
9.59 % |
08/12/2017 |
OppenheimerFunds, Inc. |
Colorado |
0 |
15094639 |
0 |
15094639 |
15094639 |
9.59 % |
08/12/2017 |
The Vanguard Group |
Pennsylvania |
289395 |
19021 |
12674430 |
298850 |
12973280 |
8.48 % |
10/02/2017 |
PRIMECAP Management Company |
|
|
|
|
|
21436186 |
14.03 % |
09/02/2017 |
First Trust Advisors L.P. The Charger Corporation |
Illinois, U.S.A. |
0 |
0 |
0 |
0 |
2083429 |
1.36 % |
31/01/2017 |
First Trust Advisors L.P. The Charger Corporation |
Illinois, U.S.A. |
0 |
0 |
0 |
0 |
2083429 |
1.36 % |
31/01/2017 |
First Trust Advisors L.P. The Charger Corporation |
Illinois, U.S.A. |
0 |
0 |
0 |
0 |
2083429 |
1.36 % |
31/01/2017 |
First Trust Advisors L.P. The Charger Corporation |
Illinois, U.S.A. |
0 |
0 |
0 |
0 |
2083429 |
1.36 % |
31/01/2017 |
Oppenheimer Global Opportunities Fund |
Delaware |
0 |
25000000 |
0 |
25000000 |
25000000 |
16.36 % |
26/01/2017 |
OppenheimerFunds, Inc. |
Colorado |
0 |
25008320 |
0 |
25008320 |
25008320 |
16.36 % |
26/01/2017 |
Oppenheimer Global Opportunities Fund |
Delaware |
0 |
25000000 |
0 |
25000000 |
25000000 |
16.36 % |
26/01/2017 |
OppenheimerFunds, Inc. |
Colorado |
0 |
25008320 |
0 |
25008320 |
25008320 |
16.36 % |
26/01/2017 |
BlackRock, Inc. |
Delaware |
18520657 |
0 |
18812677 |
0 |
18812677 |
12.3 % |
17/01/2017 |
The Vanguard Group |
Pennsylvania |
290053 |
8600 |
10175236 |
290653 |
10465889 |
7.84 % |
10/02/2016 |
Oppenheimer Global Opportunities Fund |
Delaware |
0 |
26000000 |
0 |
26000000 |
26000000 |
19.48 % |
04/02/2016 |
OppenheimerFunds, Inc. |
Colorado |
0 |
26000027 |
0 |
26000027 |
26000027 |
19.48 % |
04/02/2016 |
Oppenheimer Global Opportunities Fund |
Delaware |
0 |
26000000 |
0 |
26000000 |
26000000 |
19.48 % |
04/02/2016 |
OppenheimerFunds, Inc. |
Colorado |
0 |
26000027 |
0 |
26000027 |
26000027 |
19.48 % |
04/02/2016 |
First Trust Advisors L.P. The Charger Corporation |
Illinois, U.S.A. |
0 |
0 |
0 |
0 |
9599117 |
7.19 % |
28/01/2016 |
First Trust Advisors L.P. The Charger Corporation |
Illinois, U.S.A. |
0 |
0 |
0 |
0 |
9599117 |
7.19 % |
28/01/2016 |
BlackRock, Inc. |
Delaware |
16011624 |
0 |
16297876 |
0 |
16297876 |
12.2 % |
08/01/2016 |
BlackRock, Inc. |
Delaware |
14267042 |
0 |
14579341 |
0 |
14579341 |
11.1 % |
10/07/2015 |
PRIMECAP Management Company |
|
|
|
|
|
18225786 |
14.19 % |
13/02/2015 |
The Vanguard Group |
Pennsylvania |
174624 |
|
8139925 |
164524 |
8304449 |
6.46 % |
10/02/2015 |
BlackRock, Inc. |
Delaware |
8355497 |
0 |
8643319 |
0 |
8643319 |
6.7 % |
29/01/2015 |
PRIMECAP Management Company |
|
|
|
|
|
12498386 |
10.76 % |
14/02/2014 |
The Vanguard Group |
Pennsylvania |
167931 |
|
7365907 |
161531 |
7527438 |
6.48 % |
12/02/2014 |
Identification No: Oppenheimer Global Opportunities Fund |
Delaware |
23000000 |
0 |
0 |
23000000 |
23000000 |
19.81 % |
07/02/2014 |
OppenheimerFunds, Inc. No. |
Colorado |
0 |
23000000 |
0 |
23000000 |
23000000 |
19.81 % |
07/02/2014 |
BlackRock, Inc. |
Delaware |
7668936 |
0 |
8065265 |
0 |
8065265 |
6.9 % |
29/01/2014 |
PRIMECAP Management Company |
225 South Lake Ave., #400, Pasadena, CA 91101 |
10068775 |
0 |
12010369 |
0 |
12010369 |
0 % |
07/11/2013 |
PRIMECAP Management Company |
225 South Lake Ave., #400, Pasadena, CA 91101 |
10068775 |
0 |
12010369 |
0 |
12010369 |
0 % |
07/11/2013 |
J. Christopher Donahue |
United States |
|
5521566 |
|
5521566 |
5521566 |
4.77 % |
10/09/2013 |
Voting Shares Irrevocable Trust |
Pennsylvania |
5521566 |
|
5521566 |
|
5521566 |
4.77 % |
10/09/2013 |
John F. Donahue |
United States |
|
5521566 |
|
5521566 |
5521566 |
4.77 % |
10/09/2013 |
Federated Investors, Inc. |
Pennsylvania |
5521566 |
|
5521566 |
|
5521566 |
4.77 % |
10/09/2013 |
Rhodora J. Donahue |
United States |
|
5521566 |
|
5521566 |
5521566 |
4.77 % |
10/09/2013 |
BVF Investments, L.L.C. |
Delaware |
0 |
2734724 |
0 |
2734724 |
2734724 |
2.4 % |
14/02/2013 |
Mark N. Lampert |
United States |
0 |
2734724 |
0 |
2734724 |
2734724 |
2.4 % |
14/02/2013 |
BVF Inc. |
Delaware |
0 |
2734724 |
0 |
2734724 |
2734724 |
2.4 % |
14/02/2013 |
BVF Partners L.P. |
Delaware |
0 |
2734724 |
0 |
2734724 |
2734724 |
2.4 % |
14/02/2013 |
Investment 10, L.L.C. |
Illinois |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
PRIMECAP Management Company |
|
|
|
|
|
6469856 |
5.63 % |
14/02/2013 |
Arthur Cohen |
United States |
0 |
11000000 |
0 |
11000000 |
11000000 |
9.55 % |
14/02/2013 |
HealthCor Hybrid Offshore GP, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
HealthCor Hybrid Offshore Master Fund, L.P. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
HealthCor Offshore GP, LLC |
Delaware |
0 |
10775000 |
0 |
10775000 |
10775000 |
9.36 % |
14/02/2013 |
HealthCor Offshore Master Fund, L.P. |
Cayman Islands |
0 |
10775000 |
0 |
10775000 |
10775000 |
9.36 % |
14/02/2013 |
HealthCor Management, L.P. |
Delaware |
0 |
11000000 |
0 |
11000000 |
11000000 |
9.55 % |
14/02/2013 |
HealthCor Long Master GP, LLC |
Delaware |
0 |
225000 |
0 |
225000 |
225000 |
0.2 % |
14/02/2013 |
HealthCor Long Offshore Master Fund, L.P. |
Cayman Islands |
0 |
225000 |
0 |
225000 |
225000 |
0.2 % |
14/02/2013 |
Joseph Healey |
United States |
0 |
11000000 |
0 |
11000000 |
11000000 |
9.55 % |
14/02/2013 |
HealthCor Associates, LLC |
Delaware |
0 |
11000000 |
0 |
11000000 |
11000000 |
9.55 % |
14/02/2013 |
HealthCor Group, LLC |
Delaware |
0 |
11000000 |
0 |
11000000 |
11000000 |
9.55 % |
14/02/2013 |
Oppenheimer Global Opportunities Fund |
Massachusetts |
22700000 |
0 |
0 |
22700000 |
22700000 |
19.71 % |
13/02/2013 |
OppenheimerFunds, Inc. |
Colorado |
0 |
22700000 |
0 |
22700000 |
22700000 |
19.71 % |
13/02/2013 |
Oppenheimer Global Opportunities Fund |
Massachusetts |
22700000 |
0 |
0 |
22700000 |
22700000 |
19.71 % |
13/02/2013 |
OppenheimerFunds, Inc. |
Colorado |
0 |
22700000 |
0 |
22700000 |
22700000 |
19.71 % |
13/02/2013 |
The Vanguard Group |
Pennsylvania |
169962 |
|
6510866 |
163162 |
6674028 |
5.79 % |
12/02/2013 |
HealthCor Long Offshore Master Fund, L.P. |
Delaware |
0 |
150000 |
0 |
150000 |
150000 |
0.13 % |
13/02/2012 |
HealthCor Management, L.P. |
Delaware |
0 |
11158100 |
0 |
11158100 |
11158100 |
9.75 % |
13/02/2012 |
HealthCor Associates, LLC |
Delaware |
0 |
11158100 |
0 |
11158100 |
11158100 |
9.75 % |
13/02/2012 |
HealthCor Offshore Master Fund, L.P. |
Cayman Islands |
0 |
7573734 |
0 |
7573734 |
7573734 |
6.62 % |
13/02/2012 |
HealthCor Offshore GP, LLC |
Delaware |
0 |
7573734 |
0 |
7573734 |
7573734 |
6.62 % |
13/02/2012 |
HealthCor Hybrid Offshore Master Fund, L.P. |
Cayman Islands |
0 |
459979 |
0 |
459979 |
459979 |
0.4 % |
13/02/2012 |
HealthCor Hybrid Offshore GP, LLC |
Delaware |
0 |
459979 |
0 |
459979 |
459979 |
0.4 % |
13/02/2012 |
HealthCor Group, LLC |
Delaware |
0 |
11158100 |
0 |
11158100 |
11158100 |
9.75 % |
13/02/2012 |
HealthCor Capital, L.P. |
Delaware |
0 |
2974387 |
0 |
2974387 |
2974387 |
2.6 % |
13/02/2012 |
HealthCor, L.P. |
Delaware |
0 |
2974387 |
0 |
2974387 |
2974387 |
2.6 % |
13/02/2012 |
Arthur Cohen |
United States |
0 |
11158100 |
0 |
11158100 |
11158100 |
9.75 % |
13/02/2012 |
Joseph Healey |
United States |
0 |
11158100 |
0 |
11158100 |
11158100 |
9.75 % |
13/02/2012 |
HealthCor Long Master GP, LLC |
Delaware |
0 |
150000 |
0 |
150000 |
150000 |
0.13 % |
13/02/2012 |
Investment 10, L.L.C. |
Illinois |
0 |
151100 |
0 |
151100 |
151100 |
0 % |
23/12/2011 |
BVF Investments, L.L.C. |
Delaware |
0 |
6523600 |
0 |
6523600 |
6523600 |
5.7 % |
23/12/2011 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
459300 |
0 |
459300 |
459300 |
0 % |
23/12/2011 |
Mark N. Lampert |
United States |
0 |
7415400 |
0 |
7415400 |
7415400 |
6.5 % |
23/12/2011 |
BVF Inc. |
Delaware |
0 |
7415400 |
0 |
7415400 |
7415400 |
6.5 % |
23/12/2011 |
BVF Partners L.P. |
Delaware |
0 |
7415400 |
0 |
7415400 |
7415400 |
6.5 % |
23/12/2011 |
Investment 10, L.L.C. |
Illinois |
0 |
151100 |
0 |
151100 |
151100 |
0 % |
23/12/2011 |
BVF Investments, L.L.C. |
Delaware |
0 |
6523600 |
0 |
6523600 |
6523600 |
5.7 % |
23/12/2011 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
281400 |
0 |
281400 |
281400 |
0 % |
23/12/2011 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
459300 |
0 |
459300 |
459300 |
0 % |
23/12/2011 |
Mark N. Lampert |
United States |
0 |
7415400 |
0 |
7415400 |
7415400 |
6.5 % |
23/12/2011 |
BVF Inc. |
Delaware |
0 |
7415400 |
0 |
7415400 |
7415400 |
6.5 % |
23/12/2011 |
BVF Partners L.P. |
Delaware |
0 |
7415400 |
0 |
7415400 |
7415400 |
6.5 % |
23/12/2011 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
281400 |
0 |
281400 |
281400 |
0 % |
23/12/2011 |
PRIMECAP Management Company |
225 South Lake Ave., #400, Pasadena, CA 91101 |
4862600 |
0 |
6128100 |
0 |
6128100 |
5.39 % |
07/04/2011 |
PRIMECAP Management Company |
225 South Lake Ave., #400, Pasadena, CA 91101 |
4862600 |
0 |
6128100 |
0 |
6128100 |
5.39 % |
07/04/2011 |
BlackRock, Inc. |
Delaware |
5759101 |
0 |
5759101 |
0 |
5759101 |
6.11 % |
07/02/2011 |
BVF Inc. |
Delaware |
0 |
9012700 |
0 |
9012700 |
9012700 |
9.75 % |
13/02/2009 |
BVF Partners L.P. |
Delaware |
0 |
9012700 |
0 |
9012700 |
9012700 |
9.75 % |
13/02/2009 |
Investment 10, L.L.C. |
Illinois |
0 |
593000 |
0 |
593000 |
593000 |
0.64 % |
13/02/2009 |
BVF Investments, L.L.C. |
Delaware |
0 |
4941000 |
0 |
4941000 |
4941000 |
5.34 % |
13/02/2009 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1419000 |
0 |
1419000 |
1419000 |
1.53 % |
13/02/2009 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
2059700 |
0 |
2059700 |
2059700 |
2.23 % |
13/02/2009 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1179000 |
0 |
1179000 |
1179000 |
1.28 % |
09/10/2008 |
BVF Inc. |
Delaware |
0 |
7464800 |
0 |
7464800 |
7464800 |
8.08 % |
09/10/2008 |
BVF Partners L.P. |
Delaware |
0 |
7464800 |
0 |
7464800 |
7464800 |
8.08 % |
09/10/2008 |
Investment 10, L.L.C. |
Illinois |
0 |
505000 |
0 |
505000 |
505000 |
0.55 % |
09/10/2008 |
BVF Investments, L.L.C. |
Delaware |
0 |
4068000 |
0 |
4068000 |
4068000 |
4.4 % |
09/10/2008 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1712800 |
0 |
1712800 |
1712800 |
1.85 % |
09/10/2008 |