NuVasive, Inc. NUVA
Trading inactive
| Name of reporting person | Citizenship or organization | Sole voting power | Shared voting power | Sole dispositive power | Shared dispositive power | Amount beneficially owned | Percent of class | Accepted date |
|---|---|---|---|---|---|---|---|---|
| The Vanguard Group | Pennsylvania | 0 | 10439 | 38200 | 67267 | 105467 | 0.2 % | 11/09/2023 |
| The Vanguard Group | Pennsylvania | 0 | 10439 | 38200 | 67267 | 105467 | 0.2 % | 11/09/2023 |
| BlackRock, Inc. | Delaware | 3204514 | 0 | 3318794 | 0 | 3318794 | 6.3 % | 07/09/2023 |
| Thrivent Financial for Lutherans | Wisconsin | 65149 | 3154365 | 65149 | 3154365 | 3219514 | 6.18 % | 13/02/2023 |
| The Vanguard Group | Pennsylvania For | 0 | 88965 | 6095043 | 141069 | 6236112 | 11.96 % | 09/02/2023 |
| NuVasive, Inc. | Delaware | 1126495 | 0 | 1126495 | 0 | 1126495 | 14.4 % | 03/02/2023 |
| BlackRock, Inc. | Delaware | 8974965 | 0 | 9100878 | 0 | 9100878 | 17.5 % | 06/01/2023 |
| JPMORGAN CHASE & | Delaware | 1889344 | 0 | 2058671 | 0 | 2072136 | 3.9 % | 06/12/2022 |
| The Vanguard Group | Pennsylvania | 0 | 86331 | 5175470 | 138081 | 5313551 | 10.21 % | 11/07/2022 |
| The Vanguard Group | Pennsylvania | 0 | 86331 | 5175470 | 138081 | 5313551 | 10.21 % | 11/07/2022 |
| The Vanguard Group | Pennsylvania | 0 | 99143 | 4951273 | 145282 | 5096555 | 9.85 % | 10/02/2022 |
| The Vanguard Group | Pennsylvania | 0 | 99143 | 4951273 | 145282 | 5096555 | 9.85 % | 10/02/2022 |
| BlackRock, Inc. | Delaware | 5963909 | 0 | 6013654 | 0 | 6013654 | 11.6 % | 28/01/2022 |
| JPMORGAN CHASE & | Delaware | 2496946 | 0 | 2898128 | 5 | 2911233 | 5.6 % | 26/01/2022 |
| Wellington Management Group LLP | Massachusetts | 0 | 498399 | 0 | 567267 | 567267 | 1.09 % | 10/12/2021 |
| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 498399 | 0 | 567267 | 567267 | 1.09 % | 10/12/2021 |
| Wellington Group Holdings LLP | Delaware | 0 | 498399 | 0 | 567267 | 567267 | 1.09 % | 10/12/2021 |
| Wellington Management Group LLP | Massachusetts | 0 | 498399 | 0 | 567267 | 567267 | 1.09 % | 10/12/2021 |
| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 498399 | 0 | 567267 | 567267 | 1.09 % | 10/12/2021 |
| Wellington Group Holdings LLP | Delaware | 0 | 498399 | 0 | 567267 | 567267 | 1.09 % | 10/12/2021 |
| Wellington Management Company LLP | Delaware | 0 | 3513611 | 0 | 3896627 | 3896627 | 7.5 % | 10/09/2021 |
| Wellington Management Company LLP | Delaware | 0 | 3513611 | 0 | 3896627 | 3896627 | 7.5 % | 10/09/2021 |
| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 3542803 | 0 | 4019215 | 4019215 | 7.74 % | 10/09/2021 |
| Wellington Group Holdings LLP | Delaware | 0 | 3542803 | 0 | 4019215 | 4019215 | 7.74 % | 10/09/2021 |
| Wellington Management Group LLP | Massachusetts | 0 | 3542803 | 0 | 4019215 | 4019215 | 7.74 % | 10/09/2021 |
| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 3542803 | 0 | 4019215 | 4019215 | 7.74 % | 10/09/2021 |
| Wellington Group Holdings LLP | Delaware | 0 | 3542803 | 0 | 4019215 | 4019215 | 7.74 % | 10/09/2021 |
| Wellington Management Group LLP | Massachusetts | 0 | 3542803 | 0 | 4019215 | 4019215 | 7.74 % | 10/09/2021 |
| The Vanguard Group | Pennsylvania | 0 | 117956 | 4657591 | 159101 | 4816692 | 9.39 % | 10/02/2021 |
| THE GOLDMAN SACHS GROUP, INC. | Delaware | 0 | 2182114 | 0 | 2184345 | 2184345 | 4.3 % | 10/02/2021 |
| THE GOLDMAN SACHS GROUP, INC. | Delaware | 0 | 2182114 | 0 | 2184345 | 2184345 | 4.3 % | 10/02/2021 |
| GOLDMAN SACHS & CO. LLC | New York | 0 | 2182114 | 0 | 2184345 | 2184345 | 4.3 % | 10/02/2021 |
| GOLDMAN SACHS & CO. LLC | New York | 0 | 2182114 | 0 | 2184345 | 2184345 | 4.3 % | 10/02/2021 |
| The Hartford Mutual Funds, Inc. on behalf of: | Maryland | 2659303 | 2659303 | 2659303 | 5.19 % | 09/02/2021 | ||
| BlackRock, Inc. | Delaware | 6184636 | 0 | 6269189 | 0 | 6269189 | 12.2 % | 05/02/2021 |
| Wellington Group Holdings LLP | Delaware | 0 | 5742546 | 0 | 6670054 | 6670054 | 13.01 % | 04/02/2021 |
| Wellington Management Group LLP | Massachusetts | 0 | 5742546 | 0 | 6670054 | 6670054 | 13.01 % | 04/02/2021 |
| Wellington Management Company LLP | Delaware | 0 | 5650415 | 0 | 6292962 | 6292962 | 12.27 % | 04/02/2021 |
| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 5742546 | 0 | 6670054 | 6670054 | 13.01 % | 04/02/2021 |
| The Vanguard Group | Pennsylvania | 0 | 114765 | 5106631 | 154165 | 5260796 | 10.09 % | 09/04/2020 |
| The Vanguard Group | Pennsylvania | 0 | 114765 | 5106631 | 154165 | 5260796 | 10.09 % | 09/04/2020 |
| BANK OF AMERICA CORP /DE/560906609 | Delaware | 0 | 2554946 | 0 | 2557150 | 2557165 | 4.9 % | 14/02/2020 |
| The Hartford Mutual Funds, Inc. on behalf of: Hartford Midcap Fund and Hartford Healthcare Fund. | Maryland | 2866401 | 2866401 | 2866401 | 5.5 % | 14/02/2020 | ||
| The Vanguard Group | Pennsylvania | 108948 | 7273 | 5003660 | 109904 | 5113564 | 9.81 % | 11/02/2020 |
| BlackRock, Inc. | Delaware | 6252188 | 0 | 6340925 | 0 | 6340925 | 12.2 % | 04/02/2020 |
| THE GOLDMAN SACHS GROUP, INC. | Delaware | 0 | 2606062 | 0 | 2609127 | 2609127 | 5 % | 31/01/2020 |
| GOLDMAN SACHS & CO. LLC | New York | 0 | 2606062 | 0 | 2609127 | 2609127 | 5 % | 31/01/2020 |
| Wellington Management Group LLP | Massachusetts | 0 | 5346388 | 0 | 6061750 | 6061750 | 11.64 % | 27/01/2020 |
| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 5346388 | 0 | 6061750 | 6061750 | 11.64 % | 27/01/2020 |
| Wellington Management Group LLP | Massachusetts | 0 | 5346388 | 0 | 6061750 | 6061750 | 11.64 % | 27/01/2020 |
| Wellington Management Company LLP | Delaware | 0 | 5273195 | 0 | 5764892 | 5764892 | 11.07 % | 27/01/2020 |
| Wellington Group Holdings LLP | Delaware | 0 | 5346388 | 0 | 6061750 | 6061750 | 11.64 % | 27/01/2020 |
| Wellington Group Holdings LLP | Delaware | 0 | 5346388 | 0 | 6061750 | 6061750 | 11.64 % | 27/01/2020 |
| Wellington Management Company LLP | Delaware | 0 | 5273195 | 0 | 5764892 | 5764892 | 11.07 % | 27/01/2020 |
| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 5346388 | 0 | 6061750 | 6061750 | 11.64 % | 27/01/2020 |
| Wellington Group Holdings LLP | Delaware | 0 | 4778642 | 0 | 5637650 | 5637650 | 10.91 % | 11/03/2019 |
| Wellington Management Group LLP | Massachusetts | 0 | 4778642 | 0 | 5637650 | 5637650 | 10.91 % | 11/03/2019 |
| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 4778642 | 0 | 5637650 | 5637650 | 10.91 % | 11/03/2019 |
| Wellington Management Company LLP | Delaware | 0 | 4692163 | 0 | 5327557 | 5327557 | 10.31 % | 11/03/2019 |
| Wellington Management Company LLP | Delaware | 0 | 4692163 | 0 | 5327557 | 5327557 | 10.31 % | 11/03/2019 |
| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 4778642 | 0 | 5637650 | 5637650 | 10.91 % | 11/03/2019 |
| Wellington Group Holdings LLP | Delaware | 0 | 4778642 | 0 | 5637650 | 5637650 | 10.91 % | 11/03/2019 |
| Wellington Management Group LLP | Massachusetts | 0 | 4778642 | 0 | 5637650 | 5637650 | 10.91 % | 11/03/2019 |
| Champlain Investment Partners, LLC | Vermont | 2037815 | 0 | 2540130 | 11 | 2540130 | 4.94 % | 13/02/2019 |
| Champlain Investment Partners, LLC | Vermont | 2037815 | 0 | 2540130 | 11 | 2540130 | 4.94 % | 13/02/2019 |
| BANK OF AMERICA CORPORATION560906609 | Delaware | 0 | 2681859 | 0 | 2683846 | 2683846 | 5.29 % | 13/02/2019 |
| THE GOLDMAN SACHS GROUP, INC. | Delaware | 0 | 2533653 | 0 | 2535653 | 2535653 | 4.9 % | 12/02/2019 |
| GOLDMAN SACHS & CO. LLC | New York | 0 | 2533653 | 0 | 2535653 | 2535653 | 4.9 % | 12/02/2019 |
| Wellington Management Group LLP | Massachusetts | 0 | 3077808 | 0 | 3764198 | 3764198 | 7.32 % | 12/02/2019 |
| Wellington Group Holdings LLP | Delaware | 0 | 3077808 | 0 | 3764198 | 3764198 | 7.32 % | 12/02/2019 |
| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 3077808 | 0 | 3764198 | 3764198 | 7.32 % | 12/02/2019 |
| Wellington Management Company LLP | Delaware | 0 | 3000718 | 0 | 3482027 | 3482027 | 6.77 % | 12/02/2019 |
| The Vanguard Group | Pennsylvania | 106450 | 5975 | 4655490 | 107387 | 4762877 | 9.26 % | 11/02/2019 |
| BlackRock, Inc. | Delaware | 6118597 | 0 | 6230852 | 0 | 6230852 | 12.1 % | 31/01/2019 |
| Champlain Investment Partners, LLC | Source of Funds (See Instructions) | 2 | 2271490 | 2866247 | 5.65 % | 21/02/2018 | ||
| Champlain Investment Partners, LLC | Source of Funds (See Instructions) | 2 | 2271490 | 2866247 | 5.65 % | 21/02/2018 | ||
| Capital Research Global Investors | Delaware | 2429413 | 0 | 2429413 | 0 | 2429413 | 4.7 % | 13/02/2018 |
| Champlain Investment Partners, LLC | Vermont | 2271490 | 0 | 2866247 | 11 | 2866247 | 5.43 % | 12/02/2018 |
| Champlain Investment Partners, LLC | Vermont | 2271490 | 0 | 2866247 | 11 | 2866247 | 5.43 % | 12/02/2018 |
| GOLDMAN SACHS & CO. LLC | New York | 0 | 2870372 | 0 | 2872372 | 2872372 | 5.6 % | 09/02/2018 |
| THE GOLDMAN SACHS GROUP, INC. | Delaware | 0 | 2870372 | 0 | 2872372 | 2872372 | 5.6 % | 09/02/2018 |
| The Vanguard Group | Pennsylvania | 98851 | 5875 | 4253490 | 100488 | 4353978 | 8.54 % | 09/02/2018 |
| BlackRock, Inc. | Delaware | 5327574 | 0 | 5430528 | 0 | 5430528 | 10.7 % | 19/01/2018 |
| THE GOLDMAN SACHS GROUP, INC. | Delaware | 0 | 3990340 | 0 | 3992340 | 3992340 | 7.9 % | 27/02/2017 |
| GOLDMAN, SACHS & CO. | New York | 0 | 3990340 | 0 | 3992340 | 3992340 | 7.9 % | 27/02/2017 |
| Capital Research Global Investors | Delaware | 4823995 | 0 | 4823995 | 0 | 4823995 | 9.5 % | 13/02/2017 |
| The Vanguard Group | Pennsylvania | 98580 | 5875 | 3817274 | 102017 | 3919291 | 7.78 % | 10/02/2017 |
| BlackRock, Inc. | Delaware | 4941078 | 0 | 5043489 | 0 | 5043489 | 10 % | 08/02/2017 |
| BlackRock, Inc. | Delaware | 4882600 | 0 | 5029771 | 0 | 5029771 | 9.99 % | 25/01/2017 |
| Capital Research Global Investors | Delaware | 3525400 | 0 | 3525400 | 0 | 3525400 | 7.2 % | 12/02/2016 |
| The Vanguard Group | Pennsylvania | 106642 | 2800 | 3627639 | 106450 | 3734089 | 7.6 % | 11/02/2016 |
| Integrated Core Strategies (US) LLC | 1092178 | 2.2 % | 04/02/2016 | |||||
| Israel A. Englander | 1421719 | 2.9 % | 04/02/2016 | |||||
| Millennium Management LLC | 1421719 | 2.9 % | 04/02/2016 | |||||
| Millennium International Management GP LLC | 227173 | 0.5 % | 04/02/2016 | |||||
| Millennium International Management LP | 227173 | 0.5 % | 04/02/2016 | |||||
| Integrated Assets, Ltd. | 227173 | 0.5 % | 04/02/2016 | |||||
| ICS Opportunities, Ltd. | 0 | 0 % | 04/02/2016 | |||||
| Integrated Assets II LLC | 102368 | 0.2 % | 04/02/2016 | |||||
| Integrated Core Strategies (US) LLC | 1092178 | 2.2 % | 04/02/2016 | |||||
| Israel A. Englander | 1421719 | 2.9 % | 04/02/2016 | |||||
| Millennium Management LLC | 1421719 | 2.9 % | 04/02/2016 | |||||
| Millennium International Management GP LLC | 227173 | 0.5 % | 04/02/2016 | |||||
| Millennium International Management LP | 227173 | 0.5 % | 04/02/2016 | |||||
| Integrated Assets, Ltd. | 227173 | 0.5 % | 04/02/2016 | |||||
| ICS Opportunities, Ltd. | 0 | 0 % | 04/02/2016 | |||||
| Integrated Assets II LLC | 102368 | 0.2 % | 04/02/2016 | |||||
| BlackRock, Inc. | Delaware | 5713525 | 0 | 5844234 | 0 | 5844234 | 11.9 % | 08/01/2016 |
| ICS Opportunities, Ltd. | Cayman Islands | 0 | 1063791 | 0 | 1063791 | 1063791 | 2.2 % | 10/06/2015 |
| Millennium International Management LP | Delaware | 0 | 1373656 | 0 | 1373656 | 1373656 | 2.8 % | 10/06/2015 |
| Israel A. Englander | United States | 0 | 2552568 | 0 | 2552568 | 2552568 | 5.3 % | 10/06/2015 |
| Millennium Management LLC | Delaware | 0 | 2552568 | 0 | 2552568 | 2552568 | 5.3 % | 10/06/2015 |
| Millennium International Management GP LLC | Delaware | 0 | 1373656 | 0 | 1373656 | 1373656 | 2.8 % | 10/06/2015 |
| Millennium International Management LP | Delaware | 0 | 1373656 | 0 | 1373656 | 1373656 | 2.8 % | 10/06/2015 |
| Integrated Assets, Ltd. | Cayman Islands | 0 | 309865 | 0 | 309865 | 309865 | 0.6 % | 10/06/2015 |
| Millennium International Management GP LLC | Delaware | 0 | 1373656 | 0 | 1373656 | 1373656 | 2.8 % | 10/06/2015 |
| Integrated Core Strategies | Delaware | 0 | 1178912 | 0 | 1178912 | 1178912 | 2.4 % | 10/06/2015 |
| Millennium Management LLC | Delaware | 0 | 2552568 | 0 | 2552568 | 2552568 | 5.3 % | 10/06/2015 |
| Integrated Assets, Ltd. | Cayman Islands | 0 | 309865 | 0 | 309865 | 309865 | 0.6 % | 10/06/2015 |
| ICS Opportunities, Ltd. | Cayman Islands | 0 | 1063791 | 0 | 1063791 | 1063791 | 2.2 % | 10/06/2015 |
| Israel A. Englander | United States | 0 | 2552568 | 0 | 2552568 | 2552568 | 5.3 % | 10/06/2015 |
| Integrated Core Strategies | Delaware | 0 | 1178912 | 0 | 1178912 | 1178912 | 2.4 % | 10/06/2015 |
| Capital Research Global Investors | Delaware | 4243036 | 0 | 4243036 | 0 | 4243036 | 9 % | 13/02/2015 |
| The Vanguard Group | Pennsylvania | 63890 | 3120188 | 59798 | 3179986 | 6.76 % | 10/02/2015 | |
| BlackRock, Inc. | Delaware | 5008390 | 0 | 5112184 | 0 | 5112184 | 10.9 % | 09/01/2015 |
| S Deerfield Partners, L.P. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2014 |
| S Deerfield Management Company, L.P. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2014 |
| S James E. Flynn | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2014 |
| S Deerfield Mgmt, L.P. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2014 |
| S Deerfield International Master Fund, L.P. | British Virgin Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2014 |
| Capital Research Global Investors | Delaware | 3590522 | 0 | 3590522 | 0 | 3590522 | 8 % | 12/02/2014 |
| Capital Research Global Investors | Delaware | 3590522 | 0 | 3590522 | 0 | 3590522 | 8 % | 12/02/2014 |
| The Vanguard Group | Pennsylvania | 65329 | 2813768 | 62737 | 2876505 | 6.44 % | 12/02/2014 | |
| BlackRock, Inc. | Delaware | 4721501 | 0 | 4863463 | 0 | 4863463 | 10.9 % | 10/01/2014 |
| S James E. Flynn | United States | 0 | 3765956 | 0 | 3765956 | 3765956 | 8.3 % | 14/02/2013 |
| S Deerfield International Master Fund, L.P. | British Virgin Islands | 0 | 2150467 | 0 | 2150467 | 2150467 | 4.82 % | 14/02/2013 |
| S Deerfield Mgmt, L.P. | Delaware | 0 | 3765956 | 0 | 3765956 | 3765956 | 8.3 % | 14/02/2013 |
| S Deerfield Management Company, L.P. | Delaware | 0 | 3765956 | 0 | 3765956 | 3765956 | 8.3 % | 14/02/2013 |
| S Deerfield Partners, L.P. | Delaware | 0 | 1615489 | 0 | 1615489 | 1615489 | 3.64 % | 14/02/2013 |
| Wellington Management Company, LLP | Massachusetts | 0 | 339648 | 0 | 1983952 | 1983952 | 4.56 % | 14/02/2013 |
| Wellington Management Company, LLP | Massachusetts | 0 | 339648 | 0 | 1983952 | 1983952 | 4.56 % | 14/02/2013 |
| Capital Research Global Investors | Delaware | 3831522 | 0 | 3831522 | 0 | 3831522 | 8.8 % | 13/02/2013 |
| SMALLCAP World Fund, Inc. | Maryland | 0 | 0 | 0 | 0 | 1564436 | 3.6 % | 13/02/2013 |
| The Vanguard Group | Pennsylvania | 67183 | 2487959 | 64591 | 2552550 | 5.86 % | 11/02/2013 | |
| BlackRock, Inc. | Delaware | 4762085 | 0 | 4762085 | 0 | 4762085 | 10.94 % | 10/01/2013 |
| BlackRock, Inc. | Delaware | 4407620 | 0 | 4407620 | 0 | 4407620 | 10.21 % | 10/07/2012 |
| Deerfield Partners, L.P. | Delaware | 0 | 1211275 | 0 | 1211275 | 1211275 | 2.82 % | 14/02/2012 |
| Deerfield Management Company, L.P. | Delaware | 0 | 1618789 | 0 | 1618789 | 1618789 | 3.74 % | 14/02/2012 |
| Deerfield International Limited | British Virgin Islands | 0 | 1618789 | 0 | 1618789 | 1618789 | 3.74 % | 14/02/2012 |
| Deerfield Capital, L.P. | Delaware | 0 | 1211275 | 0 | 1211275 | 1211275 | 2.82 % | 14/02/2012 |
| James E. Flynn | United States | 0 | 2830064 | 0 | 2830064 | 2830064 | 6.43 % | 14/02/2012 |
| BlackRock, Inc. | Delaware | 3647347 | 0 | 3647347 | 0 | 3647347 | 8.63 % | 10/02/2012 |
| Capital Research Global Investors | Delaware | 5174622 | 0 | 5174622 | 0 | 5174622 | 12.2 % | 09/02/2012 |
| THE VANGUARD GROUP, INC. | Pennsylvania | 57321 | 2110727 | 57321 | 2168048 | 5.13 % | 08/02/2012 | |
| VANGUARD SPECIALIZED FUNDS VANGUARD HEALTH CARE FUND | Delaware | 1680103 | 1680103 | 3.97 % | 26/01/2012 | |||
| Lord, Abbett & Co. LLC | Delaware | 619613 | 0 | 650313 | 0 | 651114 | 1.63 % | 10/11/2011 |
| Lord, Abbett & Co. LLC | Delaware | 619613 | 0 | 650313 | 0 | 651114 | 1.63 % | 10/11/2011 |
| Deerfield Partners, L.P. | Delaware | 0 | 915118 | 0 | 915118 | 915118 | 2.27 % | 19/07/2011 |
| Deerfield Capital, L.P. | Delaware | 0 | 915118 | 0 | 915118 | 915118 | 2.27 % | 19/07/2011 |
| Deerfield Capital, L.P. | Delaware | 0 | 915118 | 0 | 915118 | 915118 | 2.27 % | 19/07/2011 |
| Deerfield International Limited | British Virgin Islands | 0 | 1222991 | 0 | 1222991 | 1222991 | 3.02 % | 19/07/2011 |
| Deerfield Management Company, L.P. | Delaware | 0 | 1222991 | 0 | 1222991 | 1222991 | 3.02 % | 19/07/2011 |
| Deerfield Management Company, L.P. | Delaware | 0 | 1222991 | 0 | 1222991 | 1222991 | 3.02 % | 19/07/2011 |
| James E. Flynn | United States | 0 | 2138109 | 0 | 2138109 | 2138109 | 5.2 % | 19/07/2011 |
| James E. Flynn | United States | 0 | 2138109 | 0 | 2138109 | 2138109 | 5.2 % | 19/07/2011 |
| Deerfield International Limited | British Virgin Islands | 0 | 1222991 | 0 | 1222991 | 1222991 | 3.02 % | 19/07/2011 |
| Deerfield Partners, L.P. | Delaware | 0 | 915118 | 0 | 915118 | 915118 | 2.27 % | 19/07/2011 |
| Lord, Abbett & Co. LLC | Delaware | 4321725 | 0 | 4760425 | 0 | 4775449 | 12.04 % | 10/06/2011 |
| Lord, Abbett & Co. LLC | Delaware | 4321725 | 0 | 4760425 | 0 | 4775449 | 12.04 % | 10/06/2011 |
| VANGUARD SPECIALIZED FUNDS VANGUARD HEALTH CARE FUND | Delaware | 2130103 | 2130103 | 5.4 % | 28/02/2011 | |||
| S Wellington Management Company, LLP | Massachusetts | 0 | 2872415 | 0 | 5301498 | 5301498 | 13.45 % | 14/02/2011 |
| Capital Research Global Investors | Delaware | 4301822 | 0 | 4301822 | 0 | 4301822 | 10.9 % | 10/02/2011 |
| VANGUARD SPECIALIZED FUNDS VANGUARD HEALTH CARE FUND | Delaware For | 2130103 | 0 | 0 | 0 | 2130103 | 5.4 % | 10/02/2011 |
| Capital Research Global Investors | Delaware | 2918822 | 0 | 2918822 | 0 | 2918822 | 7.4 % | 09/02/2011 |
| BlackRock, Inc. | Delaware | 2246192 | 0 | 2246192 | 0 | 2246192 | 5.7 % | 07/02/2011 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 2647117 | 0 | 2647117 | 6.714 % | 10/01/2011 |
| FMR LLC | Delaware | 0 | 0 | 2647117 | 0 | 2647117 | 6.714 % | 10/01/2011 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 2647117 | 0 | 2647117 | 6.714 % | 10/01/2011 |
| FMR LLC | Delaware | 0 | 0 | 2647117 | 0 | 2647117 | 6.714 % | 10/01/2011 |
| Wellington Management Company, LLP | Massachusetts | 0 | 2538455 | 0 | 5383705 | 5383705 | 13.65 % | 10/12/2010 |
| Wellington Management Company, LLP | Massachusetts | 0 | 2538455 | 0 | 5383705 | 5383705 | 13.65 % | 10/12/2010 |
| Fargo and Company | Delaware | 1508713 | 6012 | 1749687 | 43127 | 1796504 | 4.63 % | 12/04/2010 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 5732722 | 0 | 5732722 | 15 % | 16/02/2010 |
| FMR LLC | Delaware | 0 | 0 | 5732722 | 0 | 5732722 | 15 % | 16/02/2010 |
| Fargo and Company | Delaware | 1606085 | 2799 | 2181198 | 11972 | 2215247 | 0 % | 21/01/2010 |
| William Blair Capital Management VII, L.P. | Delaware | 0 | 2795880 | 0 | 2795880 | 2795880 | 11.8 % | 01/04/2005 |
| William Blair Capital Management VII, L.C.C. | Delaware | 0 | 2795880 | 0 | 2795880 | 2795880 | 11.8 % | 01/04/2005 |
| William Blair Capital Partners VII, L.P. | Delaware | 0 | 2795880 | 0 | 2795880 | 2795880 | 11.8 % | 01/04/2005 |
| William Blair Capital Partners VII QP, L.P. | Delaware | 0 | 2795880 | 0 | 2795880 | 2795880 | 11.8 % | 01/04/2005 |
| Johnson & Johnson | New Jersey | 0 | 1491132 | 0 | 1491132 | 1491132 | 6.25 % | 03/02/2005 |
| Johnson & Johnson Development Corporation | New Jersey | 0 | 1225400 | 0 | 1225400 | 1225400 | 5.1 % | 03/02/2005 |
| Alza Corporation | Delaware | 0 | 265732 | 0 | 265732 | 265732 | 1.1 % | 03/02/2005 |