The Vanguard Group |
Pennsylvania |
0 |
224741 |
15072218 |
357816 |
15430034 |
9.63 % |
12/11/2024 |
The Vanguard Group |
Pennsylvania |
0 |
224741 |
15072218 |
357816 |
15430034 |
9.63 % |
04/11/2024 |
STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
5597236 |
0 |
6066179 |
6066179 |
4.32 % |
10/07/2024 |
SK chemicals Co., Ltd. |
Republic of Korea |
0 |
6500000 |
0 |
6500000 |
6500000 |
4.6 % |
20/06/2024 |
SK bioscience Co., Ltd. |
Republic of Korea |
0 |
6500000 |
0 |
6500000 |
6500000 |
4.6 % |
20/06/2024 |
SK discovery Co., Ltd. |
Republic of Korea |
0 |
6500000 |
0 |
6500000 |
6500000 |
4.6 % |
20/06/2024 |
Morgan Stanley |
Delaware. |
|
7281646 |
0 |
7308033 |
7308033 |
6.2 % |
09/02/2024 |
BlackRock, Inc. |
Delaware |
8323116 |
0 |
8436179 |
0 |
8436179 |
7.1 % |
26/01/2024 |
SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
14565557 |
0 |
14582725 |
14582725 |
12.28 % |
25/01/2024 |
STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
16405289 |
0 |
16775875 |
16775875 |
14.12 % |
25/01/2024 |
SK chemicals Co., Ltd. |
Republic of Korea |
0 |
6500000 |
0 |
6500000 |
6500000 |
6.4 % |
18/08/2023 |
SK bioscience Co., Ltd. |
Republic of Korea |
0 |
6500000 |
0 |
6500000 |
6500000 |
6.4 % |
18/08/2023 |
SK discovery Co., Ltd. |
Republic of Korea |
0 |
6500000 |
0 |
6500000 |
6500000 |
6.4 % |
18/08/2023 |
STATE STREET CORPORATION NO. OF THE ABOVE PERSON: |
BOSTON MASSACHUSETTS |
0 |
10268982 |
0 |
10452512 |
10452512 |
12.11 % |
10/05/2023 |
SSGA FUNDS MANAGEMENT, INC. NO. OF THE ABOVE PERSON: |
BOSTON MASSACHUSETTS |
0 |
9097572 |
0 |
9121245 |
9121245 |
10.57 % |
10/05/2023 |
The Vanguard Group |
Pennsylvania |
0 |
33983 |
8731178 |
113475 |
8844653 |
10.41 % |
09/02/2023 |
STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
5908876 |
0 |
6076518 |
6076518 |
7.15 % |
02/02/2023 |
SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
4784137 |
0 |
4807305 |
4807305 |
5.66 % |
02/02/2023 |
BlackRock, Inc. |
Delaware |
4556707 |
0 |
4808261 |
0 |
4808261 |
5.7 % |
01/02/2023 |
The Vanguard Group |
Pennsylvania |
0 |
33983 |
7882666 |
109562 |
7992228 |
10.18 % |
12/12/2022 |
The Vanguard Group |
Pennsylvania |
0 |
33983 |
7882666 |
109562 |
7992228 |
10.18 % |
12/12/2022 |
BlackRock, Inc. |
Delaware |
4036930 |
0 |
4410761 |
0 |
4410761 |
5.8 % |
11/03/2022 |
Peter Kolchinsky |
United States America |
0 |
2097794 |
0 |
2097794 |
2097794 |
2.8 % |
14/02/2022 |
RA Capital Management, L.P. |
Delaware |
0 |
2097794 |
0 |
2097794 |
2097794 |
2.8 % |
14/02/2022 |
RA Capital Management, L.P. |
Delaware |
0 |
2097794 |
0 |
2097794 |
2097794 |
2.8 % |
14/02/2022 |
Rajeev Shah |
United States America |
0 |
2097794 |
0 |
2097794 |
2097794 |
2.8 % |
14/02/2022 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
2097794 |
0 |
2097794 |
2097794 |
2.8 % |
14/02/2022 |
Peter Kolchinsky |
United States of America |
0 |
2097794 |
0 |
2097794 |
2097794 |
2.8 % |
14/02/2022 |
Rajeev Shah |
United States of America |
0 |
2097794 |
0 |
2097794 |
2097794 |
2.8 % |
14/02/2022 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
2097794 |
0 |
2097794 |
2097794 |
2.8 % |
14/02/2022 |
The Vanguard Group |
Pennsylvania |
0 |
59318 |
6787173 |
109834 |
6897007 |
9.12 % |
10/02/2022 |
The Vanguard Group |
Pennsylvania |
0 |
59318 |
6787173 |
109834 |
6897007 |
9.12 % |
10/02/2022 |
Rajeev Shah |
United States of America |
0 |
3788564 |
0 |
3788564 |
3788564 |
6 % |
16/02/2021 |
RA Capital Management, L.P. |
Delaware |
0 |
3788564 |
0 |
3788564 |
3788564 |
6 % |
16/02/2021 |
Peter Kolchinsky |
United States of America |
0 |
3788564 |
0 |
3788564 |
3788564 |
6 % |
16/02/2021 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
3605893 |
0 |
3605893 |
0 |
5.7 % |
16/02/2021 |
Rajeev Shah |
United States of America |
0 |
3788564 |
0 |
3788564 |
3788564 |
6 % |
16/02/2021 |
Peter Kolchinsky |
United States of America |
0 |
3788564 |
0 |
3788564 |
3788564 |
6 % |
16/02/2021 |
RA Capital Management, L.P. |
Delaware |
0 |
3788564 |
0 |
3788564 |
3788564 |
6 % |
16/02/2021 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
3605893 |
0 |
3605893 |
0 |
5.7 % |
16/02/2021 |
D. E. Shaw & Co., L.P. |
Delaware |
0 |
111405 |
0 |
111405 |
111405 |
0.2 % |
16/02/2021 |
David E. Shaw |
United States |
0 |
111405 |
0 |
111405 |
111405 |
0.2 % |
16/02/2021 |
D. E. Shaw & Co., L.P. |
Delaware |
0 |
111405 |
0 |
111405 |
111405 |
0.2 % |
16/02/2021 |
D. E. Shaw & Co., L.L.C. |
Delaware |
0 |
110645 |
0 |
110645 |
110645 |
0.2 % |
16/02/2021 |
David E. Shaw |
United States |
0 |
111405 |
0 |
111405 |
111405 |
0.2 % |
16/02/2021 |
D. E. Shaw & Co., L.L.C. |
Delaware |
0 |
110645 |
0 |
110645 |
110645 |
0.2 % |
16/02/2021 |
The Vanguard Group |
Pennsylvania |
0 |
83046 |
5467285 |
131475 |
5598760 |
8.79 % |
10/02/2021 |
BlackRock, Inc. |
Delaware |
5008280 |
0 |
5137631 |
0 |
5137631 |
8.1 % |
05/02/2021 |
David E. Shaw |
United States |
0 |
2902292 |
0 |
2902292 |
2902292 |
5 % |
01/06/2020 |
David E. Shaw |
United States |
0 |
2902292 |
0 |
2902292 |
2902292 |
5 % |
01/06/2020 |
D. E. Shaw & Co., L.L.C. |
Delaware |
0 |
2902232 |
0 |
2902232 |
2902232 |
5 % |
01/06/2020 |
D. E. Shaw & Co., L.P. |
Delaware |
0 |
2902292 |
0 |
2902292 |
2902292 |
5 % |
01/06/2020 |
D. E. Shaw & Co., L.P. |
Delaware |
0 |
2902292 |
0 |
2902292 |
2902292 |
5 % |
01/06/2020 |
D. E. Shaw & Co., L.L.C. |
Delaware |
0 |
2902232 |
0 |
2902232 |
2902232 |
5 % |
01/06/2020 |
The Vanguard Group |
Pennsylvania |
29767 |
0 |
1452092 |
29767 |
1481859 |
4.61 % |
12/02/2020 |
BlackRock, Inc. |
Delaware |
1811074 |
0 |
1849706 |
0 |
1849706 |
7 % |
10/02/2020 |
The Vanguard Group |
Pennsylvania |
519769 |
28900 |
20656027 |
512769 |
21168796 |
5.52 % |
11/02/2019 |
BlackRock, Inc. |
Delaware |
31615343 |
0 |
32395731 |
0 |
32395731 |
8.5 % |
11/02/2019 |
STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
12110908 |
0 |
12110908 |
12110908 |
3.86 % |
13/02/2018 |
The Vanguard Group |
Pennsylvania |
431496 |
15600 |
13953269 |
433596 |
14386865 |
4.45 % |
09/02/2018 |
BlackRock, Inc. |
Delaware |
24469007 |
0 |
25018622 |
0 |
25018622 |
8 % |
08/02/2018 |
FMR LLC |
Delaware |
0 |
0 |
7419437 |
0 |
7419437 |
2.522 % |
11/09/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
7419437 |
0 |
7419437 |
2.522 % |
11/09/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
21194137 |
0 |
21194137 |
7.813 % |
14/02/2017 |
FMR LLC |
Delaware |
178400 |
0 |
21194137 |
0 |
21194137 |
7.813 % |
14/02/2017 |
The Vanguard Group |
Pennsylvania |
536463 |
15600 |
20204174 |
538563 |
20742737 |
7.64 % |
10/02/2017 |
STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
19971040 |
0 |
19971040 |
19971040 |
7.36 % |
08/02/2017 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
45700 |
0 |
45700 |
0 |
45700 |
0 % |
07/02/2017 |
First Trust Advisors L.P. The Charger Corporation |
Illinois, U.S.A. |
0 |
0 |
0 |
0 |
0 |
0 % |
31/01/2017 |
BlackRock, Inc. |
Delaware |
20668254 |
0 |
21224265 |
0 |
21224265 |
7.8 % |
25/01/2017 |
FMR LLC |
Delaware |
211909 |
0 |
25574846 |
0 |
25574846 |
9.43 % |
10/11/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
25574846 |
0 |
25574846 |
9.43 % |
10/11/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
40445649 |
0 |
40445649 |
14.987 % |
12/02/2016 |
FMR LLC |
Delaware |
291987 |
0 |
40445649 |
0 |
40445649 |
14.987 % |
12/02/2016 |
Select Biotechnology Portfolio |
Massachusetts |
16470821 |
0 |
0 |
0 |
16470821 |
6.103 % |
12/02/2016 |
The Vanguard Group |
Pennsylvania |
590707 |
16800 |
17428305 |
589507 |
18017812 |
6.67 % |
11/02/2016 |
T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
22738991 |
8.4 % |
10/02/2016 |
First Trust Advisors L.P. The Charger Corporation |
Illinois, U.S.A. |
0 |
0 |
0 |
0 |
13525640 |
5.01 % |
05/02/2016 |
BlackRock, Inc. |
Delaware |
17358768 |
0 |
17973364 |
0 |
17973364 |
6.7 % |
27/01/2016 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
2883113 |
0 |
2883113 |
2883113 |
1.2 % |
17/02/2015 |
Peter Kolchinsky |
United States |
0 |
3241083 |
0 |
3241083 |
3241083 |
1.4 % |
17/02/2015 |
RA Capital Management, LLC |
Massachusetts |
0 |
3241083 |
0 |
|
3241083 |
1.4 % |
17/02/2015 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
24702866 |
0 |
24702866 |
10.358 % |
13/02/2015 |
Abigail P. Johnson |
United States of America |
0 |
0 |
24702866 |
0 |
24702866 |
10.358 % |
13/02/2015 |
FMR LLC |
Delaware |
2605 |
0 |
24702866 |
0 |
24702866 |
10.358 % |
13/02/2015 |
Select Biotechnology Portfolio |
Massachusetts |
14411821 |
0 |
0 |
0 |
14411821 |
6.043 % |
13/02/2015 |
T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
12377102 |
5.1 % |
11/02/2015 |
BlackRock, Inc. |
Delaware |
15734110 |
0 |
16281679 |
0 |
16281679 |
6.8 % |
29/01/2015 |
RA Capital Management, LLC |
Massachusetts |
0 |
10811888 |
0 |
10811888 |
10811888 |
5.2 % |
14/02/2014 |
Peter Kolchinsky |
United States |
0 |
10811888 |
0 |
10811888 |
10811888 |
5.2 % |
14/02/2014 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
7727149 |
0 |
7727149 |
7727149 |
3.7 % |
14/02/2014 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
25127491 |
0 |
25127491 |
12.051 % |
14/02/2014 |
FMR LLC |
Delaware |
22 |
0 |
25127491 |
0 |
25127491 |
12.051 % |
14/02/2014 |
BlackRock, Inc. |
Delaware |
12957063 |
0 |
13465749 |
0 |
13465749 |
6.5 % |
29/01/2014 |
RA Capital Management, LLC |
Massachusetts |
14411748 |
0 |
14411748 |
0 |
14411748 |
9.7 % |
14/02/2013 |
RA Capital Healthcare Fund, L.P. |
Delaware |
8250125 |
0 |
8250125 |
0 |
8250125 |
5.6 % |
14/02/2013 |
Peter Kolchinsky |
United States |
14411748 |
0 |
14411748 |
0 |
14411748 |
9.7 % |
14/02/2013 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
18872588 |
0 |
18872588 |
12.757 % |
14/02/2013 |
FMR LLC |
Delaware |
0 |
0 |
18872588 |
0 |
18872588 |
12.757 % |
14/02/2013 |
BlackRock, Inc. |
Delaware |
8326166 |
0 |
8326166 |
0 |
8326166 |
5.63 % |
30/01/2013 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
16715426 |
0 |
16715426 |
12.649 % |
10/08/2012 |
FMR LLC |
Delaware |
0 |
0 |
16715426 |
0 |
16715426 |
12.649 % |
10/08/2012 |
BlackRock, Inc. |
Delaware |
6536062 |
0 |
6536062 |
0 |
6536062 |
4.94 % |
08/06/2012 |
RA Capital Management, LLC |
Massachusetts |
13200000 |
0 |
13200000 |
0 |
13200000 |
9.9 % |
22/05/2012 |
Peter Kolchinsky |
United States |
13200000 |
0 |
13200000 |
0 |
13200000 |
9.9 % |
22/05/2012 |
RA Capital Healthcare Fund, L.P. |
Delaware |
7478029 |
0 |
7478029 |
0 |
7478029 |
5.7 % |
22/05/2012 |
Wellington Management Company, LLP |
Massachusetts |
0 |
3098995 |
0 |
4474695 |
4474695 |
3.65 % |
10/05/2012 |
Wellington Management Company, LLP |
Massachusetts |
0 |
8789065 |
0 |
11540965 |
11540965 |
9.96 % |
14/02/2012 |
BlackRock, Inc. |
Delaware |
6336672 |
0 |
6336672 |
0 |
6336672 |
5.51 % |
13/02/2012 |
Hartford Series Fund, Inc. on behalf of: Hartford Capital Appreciation HLS Fund S |
Maryland |
0 |
5134935 |
0 |
5134935 |
5134935 |
4.45 % |
03/02/2012 |
Wellington Management Company, LLP |
Massachusetts |
0 |
12846934 |
0 |
15624184 |
15624184 |
13.95 % |
14/02/2011 |
Hartford Capital Appreciation HLS Fund S.S. OR |
Maryland |
|
7157990 |
|
7157990 |
7157990 |
6.41 % |
10/02/2011 |
BlackRock, Inc. |
Delaware |
5701348 |
0 |
5701348 |
0 |
5701348 |
5.13 % |
07/02/2011 |
Wellington Management Company, LLP |
Massachusetts |
0 |
11209046 |
0 |
14164346 |
14164346 |
13.99 % |
12/02/2010 |
SS. OR |
Massachusetts |
891956 |
0 |
891956 |
0 |
891956 |
0.96 % |
09/02/2010 |
Hartford Series Fund, Inc. on behalf of: Hartford Capital Appreciation HLS Fund S |
Maryland |
0 |
6775790 |
0 |
6775790 |
6775790 |
6.72 % |
03/02/2010 |
OppenheimerFunds, Inc. |
Colorado |
0 |
1000000 |
0 |
1000000 |
1000000 |
1 % |
02/02/2010 |