| Shah, Nimish |
United States |
0 |
13760200 |
0 |
13760200 |
13760200 |
8.7 % |
14/11/2024 |
| VHCP Management EG, LLC |
Delaware |
0 |
13760200 |
0 |
13760200 |
13760200 |
8.7 % |
14/11/2024 |
| Koh, Bong |
United States |
0 |
13760200 |
0 |
13760200 |
13760200 |
8.7 % |
14/11/2024 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
13760200 |
0 |
13760200 |
13760200 |
8.7 % |
14/11/2024 |
| VHCP Holdings III, LLC |
Delaware |
0 |
13760200 |
0 |
13760200 |
13760200 |
8.7 % |
14/11/2024 |
| Venrock Healthcare Capital Partners EG, L.P. |
Delaware |
0 |
13760200 |
0 |
13760200 |
13760200 |
8.7 % |
14/11/2024 |
| VHCP Management III, LLC |
Delaware |
0 |
13760200 |
0 |
13760200 |
13760200 |
8.7 % |
14/11/2024 |
| Avoro Capital Advisors LLC |
Delaware |
12714874 |
0 |
12714874 |
0 |
12714874 |
7.9 % |
14/11/2024 |
| Behzad Aghazadeh |
United States |
12714874 |
0 |
12714874 |
0 |
12714874 |
7.9 % |
14/11/2024 |
| The Vanguard Group |
Pennsylvania |
0 |
273002 |
8010972 |
373211 |
8384183 |
5.37 % |
12/11/2024 |
| BlackRock, Inc. |
Delaware |
11206976 |
0 |
11354164 |
0 |
11354164 |
7.3 % |
08/11/2024 |
| The Vanguard Group |
Pennsylvania |
0 |
273002 |
8010972 |
373211 |
8384183 |
5.37 % |
04/11/2024 |
| BlackRock, Inc. |
Delaware |
0 |
0 |
11354164 |
0 |
11354164 |
7.3 % |
22/10/2024 |
| Opaleye Management Inc. |
Massachusetts |
0 |
6070000 |
0 |
6070000 |
6070000 |
5.51 % |
14/02/2024 |
| The Vanguard Group |
Pennsylvania |
0 |
130326 |
4959246 |
158856 |
5118102 |
4.46 % |
13/02/2024 |
| BlackRock, Inc. |
Delaware |
5714350 |
0 |
5761533 |
0 |
5761533 |
5.2 % |
31/01/2024 |
| Venrock Healthcare Capital Partners EG, L.P. |
Delaware |
0 |
7775760 |
0 |
7775760 |
7775760 |
6.8 % |
28/12/2023 |
| VHCP Holdings III, LLC |
Delaware |
0 |
7775760 |
0 |
7775760 |
7775760 |
6.8 % |
28/12/2023 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
7775760 |
0 |
7775760 |
7775760 |
6.8 % |
28/12/2023 |
| VHCP Management III, LLC |
Delaware |
0 |
7775760 |
0 |
7775760 |
7775760 |
6.8 % |
28/12/2023 |
| VHCP Management EG, LLC |
Delaware |
0 |
7775760 |
0 |
7775760 |
7775760 |
6.8 % |
28/12/2023 |
| Shah, Nimish |
United States |
0 |
7775760 |
0 |
7775760 |
7775760 |
6.8 % |
28/12/2023 |
| Koh, Bong |
United States |
0 |
7775760 |
0 |
7775760 |
7775760 |
6.8 % |
28/12/2023 |
| Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
9230769 |
0 |
9230769 |
0 |
8.38 % |
22/12/2023 |
| Deep Track Capital, LP |
Delaware |
0 |
9230769 |
0 |
9230769 |
0 |
8.38 % |
22/12/2023 |
| Deep Track Capital, LP |
Delaware |
0 |
9230769 |
0 |
9230769 |
0 |
8.38 % |
22/12/2023 |
| Deep Track Biotechnology Master Fund, Ltd. |
Cayman Islands |
0 |
9230769 |
0 |
9230769 |
0 |
8.38 % |
22/12/2023 |
| David Kroin |
United States |
0 |
9230769 |
0 |
9230769 |
0 |
8.38 % |
22/12/2023 |
| David Kroin |
United States |
0 |
9230769 |
0 |
9230769 |
0 |
8.38 % |
22/12/2023 |
| The Vanguard Group |
Pennsylvania For |
0 |
115191 |
3833132 |
143721 |
3976853 |
5.16 % |
09/02/2023 |
| BlackRock, Inc. |
Delaware |
4916784 |
0 |
4952737 |
0 |
4952737 |
6.4 % |
31/01/2023 |
| The Vanguard Group |
Pennsylvania For |
0 |
143447 |
3881954 |
197069 |
4079023 |
5.32 % |
10/02/2022 |
| BlackRock, Inc. |
Delaware |
5035915 |
0 |
5122835 |
0 |
5122835 |
6.7 % |
02/02/2022 |
| Opaleye Management Inc. |
Massachusetts |
0 |
5974800 |
0 |
5974800 |
5974800 |
7.8 % |
31/01/2022 |
| Opaleye Management Inc. |
Massachusetts |
0 |
5974800 |
0 |
5974800 |
5974800 |
7.8 % |
31/01/2022 |
| CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Massachusetts |
0 |
6510000 |
0 |
6510000 |
6510000 |
8.65 % |
12/02/2021 |
| James Silverman CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
United States |
0 |
6510000 |
0 |
6510000 |
6510000 |
8.65 % |
12/02/2021 |
| Opaleye, L.P. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Delaware |
0 |
6510000 |
0 |
6510000 |
6510000 |
8.65 % |
12/02/2021 |
| BlackRock, Inc. |
Delaware |
5444044 |
0 |
5512264 |
0 |
5512264 |
7.3 % |
02/02/2021 |
| BlackRock, Inc. |
Delaware |
2969231 |
0 |
3006167 |
0 |
3006167 |
4.8 % |
09/06/2020 |
| Versant Side Fund III, L.P. |
Delaware United States America |
13007 |
0 |
13007 |
0 |
13007 |
0.1 % |
14/02/2020 |
| Versant Ventures III, LLC |
Delaware United States America |
0 |
2215384 |
0 |
2215384 |
2215384 |
4.6 % |
14/02/2020 |
| Versant Venture Capital III, L.P. |
Delaware United States America |
2202377 |
0 |
2202377 |
0 |
2202377 |
4.6 % |
14/02/2020 |
| MAN GROUP PLC |
Jersey |
0 |
760490 |
0 |
760490 |
760490 |
1.58 % |
10/02/2020 |
| MAN GROUP PLC |
Jersey |
0 |
760490 |
0 |
760490 |
760490 |
1.58 % |
10/02/2020 |
| GLG PARTNERS LP |
United Kingdom |
0 |
760490 |
0 |
760490 |
760490 |
1.58 % |
10/02/2020 |
| GLG PARTNERS LP |
United Kingdom |
0 |
760490 |
0 |
760490 |
760490 |
1.58 % |
10/02/2020 |
| CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Massachusetts |
0 |
5126000 |
0 |
5126000 |
5126000 |
10.66 % |
10/01/2020 |
| Opaleye, L.P. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Delaware |
0 |
5126000 |
0 |
5126000 |
5126000 |
10.66 % |
10/01/2020 |
| CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Massachusetts |
0 |
5126000 |
0 |
5126000 |
5126000 |
10.66 % |
10/01/2020 |
| Opaleye, L.P. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Delaware |
0 |
5126000 |
0 |
5126000 |
5126000 |
10.66 % |
10/01/2020 |
| James Silverman CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
United States |
0 |
5126000 |
0 |
5126000 |
5126000 |
10.66 % |
10/01/2020 |
| James Silverman CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
United States |
0 |
5126000 |
0 |
5126000 |
5126000 |
10.66 % |
10/01/2020 |
| MAN GROUP PLC |
Jersey |
0 |
2457787 |
0 |
2457787 |
2457787 |
5.74 % |
31/05/2019 |
| GLG PARTNERS LP |
United Kingdom |
0 |
2457787 |
0 |
2457787 |
2457787 |
5.74 % |
31/05/2019 |
| MAN GROUP PLC |
Jersey |
0 |
2457787 |
0 |
2457787 |
2457787 |
5.74 % |
31/05/2019 |
| GLG PARTNERS LP |
United Kingdom |
0 |
2457787 |
0 |
2457787 |
2457787 |
5.74 % |
31/05/2019 |
| CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Massachusetts |
0 |
2200000 |
0 |
2200000 |
2200000 |
5.14 % |
03/05/2019 |
| CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Massachusetts |
0 |
2200000 |
0 |
2200000 |
2200000 |
5.14 % |
03/05/2019 |
| Opaleye, L.P. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Delaware |
0 |
2200000 |
0 |
2200000 |
2200000 |
5.14 % |
03/05/2019 |
| James Silverman CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
United States |
0 |
2200000 |
0 |
2200000 |
2200000 |
5.14 % |
03/05/2019 |
| Opaleye, L.P. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Delaware |
0 |
2200000 |
0 |
2200000 |
2200000 |
5.14 % |
03/05/2019 |
| James Silverman CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
United States |
0 |
2200000 |
0 |
2200000 |
2200000 |
5.14 % |
03/05/2019 |
| Summer Road LLC |
Delaware |
3804788 |
0 |
3804788 |
0 |
3804788 |
9.3 % |
14/02/2019 |
| Summer Road LLC |
Delaware |
3804788 |
0 |
3804788 |
0 |
3804788 |
9.3 % |
14/02/2019 |
| FMR LLC |
Delaware |
0 |
0 |
2033599 |
0 |
2033599 |
4.926 % |
13/02/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2033599 |
0 |
2033599 |
4.926 % |
13/02/2019 |
| BlackRock, Inc. |
Delaware |
2743870 |
0 |
2792752 |
0 |
2792752 |
6.8 % |
07/02/2019 |
| Jennison Associates LLC S.S. or |
Delaware |
1632646 |
0 |
0 |
1632646 |
1632646 |
4 % |
01/02/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2099099 |
0 |
2099099 |
5.107 % |
10/12/2018 |
| FMR LLC |
Delaware |
0 |
0 |
2099099 |
0 |
2099099 |
5.107 % |
10/12/2018 |
| FMR LLC |
Delaware |
0 |
0 |
2099099 |
0 |
2099099 |
5.107 % |
10/12/2018 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2099099 |
0 |
2099099 |
5.107 % |
10/12/2018 |
| SV Life Sciences Fund IV, L.P. |
DELAWARE |
1605207 |
0 |
1605207 |
0 |
1605207 |
4.4 % |
14/02/2018 |
| SVLSF IV, LLC |
DELAWARE |
1605207 |
0 |
1605207 |
0 |
1605207 |
4.4 % |
14/02/2018 |
| SV Life Sciences Fund IV (GP), L.P. |
DELAWARE |
1605207 |
0 |
1605207 |
0 |
1605207 |
4.4 % |
14/02/2018 |
| SV Life Sciences Fund IV Strategic Partners, L.P. |
DELAWARE |
1605207 |
0 |
1605207 |
0 |
1605207 |
4.4 % |
14/02/2018 |
| Summer Road LLC |
Delaware |
3027488 |
0 |
3027488 |
0 |
3027488 |
8.4 % |
08/02/2018 |
| Summer Road LLC |
Delaware |
3027488 |
0 |
3027488 |
0 |
3027488 |
8.4 % |
08/02/2018 |
| Summer Road LLC |
Delaware |
3027488 |
0 |
3027488 |
0 |
3027488 |
8.4 % |
07/02/2018 |
| Summer Road LLC |
Delaware |
3027488 |
0 |
3027488 |
0 |
3027488 |
8.4 % |
07/02/2018 |
| Jennison Associates LLC S.S. or |
Delaware |
1994768 |
0 |
0 |
1994768 |
1994768 |
6.8 % |
06/02/2018 |
| Jennison Associates LLC S.S. or |
Delaware |
1985496 |
0 |
0 |
1985496 |
1985496 |
6.8 % |
10/07/2017 |
| Capital World Investors |
Delaware |
0 |
0 |
0 |
0 |
4 |
0 % |
13/02/2017 |
| SVLSF IV, LLC |
DELAWARE |
1605207 |
0 |
1605207 |
0 |
1605207 |
6.5 % |
07/02/2017 |
| SV Life Sciences Fund IV (GP), L.P. |
DELAWARE |
1605207 |
0 |
1605207 |
0 |
1605207 |
6.5 % |
07/02/2017 |
| SV Life Sciences Fund IV, L.P. |
DELAWARE |
1605207 |
0 |
1605207 |
0 |
1605207 |
6.5 % |
07/02/2017 |
| SV Life Sciences Fund IV Strategic Partners, L.P. |
DELAWARE |
1605207 |
0 |
1605207 |
0 |
1605207 |
6.5 % |
07/02/2017 |
| Jennison Associates LLC S.S. or |
Delaware |
3216881 |
0 |
0 |
3216881 |
3216881 |
12.9 % |
03/02/2017 |
| Capital Research Global Investors |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
08/07/2016 |
| Capital Research Global Investors |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
08/07/2016 |
| Jennison Associates LLC S.S. or |
Delaware |
2972606 |
0 |
0 |
2972606 |
2972606 |
12 % |
08/07/2016 |
| SV Life Sciences Fund IV (GP), L.P. |
DELAWARE |
1932607 |
0 |
1932607 |
0 |
1932607 |
7.8 % |
16/02/2016 |
| SV Life Sciences Fund IV, L.P. |
DELAWARE |
1932607 |
0 |
1932607 |
0 |
1932607 |
7.8 % |
16/02/2016 |
| SVLSF IV, LLC |
DELAWARE |
1932607 |
0 |
1932607 |
0 |
1932607 |
7.8 % |
16/02/2016 |
| SV Life Sciences Fund IV Strategic Partners, L.P. |
DELAWARE |
1932607 |
0 |
1932607 |
0 |
1932607 |
7.8 % |
16/02/2016 |
| ASCENSION HEALTH VENTURES II, LLC (dba Ascension Ventures, LLC) |
Missouri |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2016 |
| CHV II, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2016 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
3710128 |
0 |
3710128 |
14.999 % |
12/02/2016 |
| Select Biotechnology Portfolio |
Massachusetts |
1463827 |
0 |
0 |
0 |
1463827 |
5.918 % |
12/02/2016 |
| FMR LLC |
Delaware |
550 |
0 |
3710128 |
0 |
3710128 |
14.999 % |
12/02/2016 |
| FMR LLC |
Delaware |
550 |
0 |
3710128 |
0 |
3710128 |
14.999 % |
12/02/2016 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
3710128 |
0 |
3710128 |
14.999 % |
12/02/2016 |
| Select Biotechnology Portfolio |
Massachusetts |
1463827 |
0 |
0 |
0 |
1463827 |
5.918 % |
12/02/2016 |
| Wellington Management Group LLP |
Massachusetts |
0 |
793215 |
0 |
930605 |
930605 |
3.76 % |
11/02/2016 |
| Wellington Group Holdings LLP |
Delaware |
0 |
793215 |
0 |
930605 |
930605 |
3.76 % |
11/02/2016 |
| Wellington Management Group LLP |
Massachusetts |
0 |
793215 |
0 |
930605 |
930605 |
3.76 % |
11/02/2016 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
793215 |
0 |
930605 |
930605 |
3.76 % |
11/02/2016 |
| Wellington Group Holdings LLP |
Delaware |
0 |
793215 |
0 |
930605 |
930605 |
3.76 % |
11/02/2016 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
793215 |
0 |
930605 |
930605 |
3.76 % |
11/02/2016 |
| Voting Shares Irrevocable Trust |
|
1647233 |
|
1647233 |
|
1647233 |
6.66 % |
11/02/2016 |
| J. Christopher Donahue |
|
|
1647233 |
|
1647233 |
1647233 |
6.66 % |
11/02/2016 |
| Rhodora J. Donahue |
|
|
1647233 |
|
1647233 |
1647233 |
6.66 % |
11/02/2016 |
| (entities only Federated Investors, Inc. |
|
1647233 |
|
1647233 |
|
1647233 |
6.66 % |
11/02/2016 |
| John F. Donahue |
|
|
1647233 |
|
1647233 |
1647233 |
6.66 % |
11/02/2016 |
| Samuel D. Colella |
United States America |
0 |
2215384 |
0 |
2215384 |
2215384 |
9 % |
09/02/2016 |
| Versant Ventures III, LLC |
Delaware United States America |
0 |
2215384 |
0 |
2215384 |
2215384 |
9 % |
09/02/2016 |
| Robin L. Praeger |
United States America |
0 |
2215384 |
0 |
2215384 |
2215384 |
9 % |
09/02/2016 |
| Versant Side Fund III, L.P. |
Delaware United States America |
13007 |
0 |
13007 |
0 |
13007 |
0.1 % |
09/02/2016 |
| Versant Venture Capital III, L.P. |
Delaware United States America |
2202377 |
0 |
2202377 |
0 |
2202377 |
8.9 % |
09/02/2016 |
| Brian G. Atwood |
United States America |
0 |
2215384 |
0 |
2215384 |
2215384 |
9 % |
09/02/2016 |
| Donald B. Milder |
United States America |
0 |
2215384 |
0 |
2215384 |
2215384 |
9 % |
09/02/2016 |
| William J. Link |
United States America |
0 |
2215384 |
0 |
2215384 |
2215384 |
9 % |
09/02/2016 |
| Barbara N. Lubash |
United States America |
0 |
2215384 |
0 |
2215384 |
2215384 |
9 % |
09/02/2016 |
| Ross A. Jaffe |
United States America |
0 |
2215384 |
0 |
2215384 |
2215384 |
9 % |
09/02/2016 |
| Charles M. Warden |
United States America |
6944 |
2215384 |
6944 |
2215384 |
2222328 |
9 % |
09/02/2016 |
| Bradley J. Bolzon |
Canada |
0 |
2215384 |
0 |
2215384 |
2215384 |
9 % |
09/02/2016 |
| Rebecca B. Robertson |
United States America |
0 |
2215384 |
0 |
2215384 |
2215384 |
9 % |
09/02/2016 |
| Capital Research Global Investors |
Delaware |
2843480 |
0 |
2843480 |
0 |
2843480 |
11.5 % |
10/07/2015 |
| Capital Research Global Investors |
Delaware |
2843480 |
0 |
2843480 |
0 |
2843480 |
11.5 % |
10/07/2015 |
| FMR LLC |
Delaware |
0 |
0 |
2181321 |
0 |
2181321 |
10.174 % |
10/06/2015 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2181321 |
0 |
2181321 |
10.174 % |
10/06/2015 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
2181321 |
0 |
2181321 |
10.174 % |
10/06/2015 |
| FMR LLC |
Delaware |
0 |
0 |
2181321 |
0 |
2181321 |
10.174 % |
10/06/2015 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2181321 |
0 |
2181321 |
10.174 % |
10/06/2015 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
2181321 |
0 |
2181321 |
10.174 % |
10/06/2015 |
| Wellington Management Group LLP |
Massachusetts |
0 |
1170540 |
0 |
1296690 |
1296690 |
6.08 % |
12/02/2015 |
| ASCENSION HEALTH VENTURES II, LLC |
Missouri |
2100138 |
|
2100138 |
|
2100138 |
9.849 % |
10/02/2015 |
| CHV II, L.P. |
Delaware |
2100138 |
|
2100138 |
|
2100138 |
9.849 % |
10/02/2015 |
| Polaris Venture Partners V, L.P. |
Delaware |
2441293 |
2441293 |
2441293 |
2441293 |
2441293 |
11.9 % |
11/08/2014 |
| Polaris Venture Partners Entrepreneurs’ Fund V, L.P. |
Delaware |
47581 |
47581 |
47581 |
47581 |
47581 |
0.2 % |
11/08/2014 |
| Jonathan A. Flint |
USA |
2530009 |
2530009 |
2530009 |
2530009 |
2530009 |
12.3 % |
11/08/2014 |
| Terrance G. McGuire |
USA |
2530009 |
2530009 |
2530009 |
2530009 |
2530009 |
12.3 % |
11/08/2014 |
| Polaris Venture Management Co. V, L.L.C. |
Delaware |
2530009 |
2530009 |
2530009 |
2530009 |
2530009 |
12.3 % |
11/08/2014 |
| Polaris Venture Partners Special Founders’ Fund V, L.P. |
Delaware |
24412 |
24412 |
24412 |
24412 |
24412 |
0.1 % |
11/08/2014 |
| Polaris Venture Partners Founders’ Fund V, L.P. |
Delaware |
16723 |
16723 |
16723 |
16723 |
16723 |
0.1 % |
11/08/2014 |
| SV Life Sciences Fund IV, L.P. |
DELAWARE |
2585607 |
0 |
2585607 |
0 |
2585607 |
12.6 % |
05/08/2014 |
| SVLSF IV, LLC |
DELAWARE |
2585607 |
0 |
2585607 |
0 |
2585607 |
12.6 % |
05/08/2014 |
| SV Life Sciences Fund IV Strategic Partners, L.P. |
DELAWARE |
2585607 |
0 |
2585607 |
0 |
2585607 |
12.6 % |
05/08/2014 |
| SV Life Sciences Fund IV |
DELAWARE |
2585607 |
0 |
2585607 |
0 |
2585607 |
12.6 % |
05/08/2014 |
| Farhad Khosravi |
United States |
179654 |
932768 |
179654 |
932768 |
1112422 |
5.4 % |
04/08/2014 |
