| 30-0447847 |
Delaware |
3823054 |
0 |
3906687 |
0 |
3906687 |
5.3 % |
09/02/2024 |
| 30-0447847 |
Delaware |
3823054 |
0 |
3906687 |
0 |
3906687 |
5.3 % |
09/02/2024 |
| Camber Capital Management LP |
Delaware |
0 |
4250000 |
0 |
4250000 |
2013 |
5.85 % |
02/02/2023 |
| Camber Capital Management LP |
Delaware |
0 |
4250000 |
0 |
4250000 |
2013 |
5.85 % |
02/02/2023 |
| (1) BlackRock, Inc. |
Delaware |
13510616 |
0 |
13893887 |
0 |
13893887 |
19.3 % |
28/01/2022 |
| MANAGED ACCOUNT ADVISORS LLC000000000 |
Delaware |
0 |
0 |
4255738 |
65641 |
4321379 |
6 % |
26/01/2022 |
| Stephen
DuBois |
|
0 |
4250000 |
0 |
4250000 |
4250000 |
5.9 % |
08/11/2021 |
| Stephen
DuBois |
or Place of Organization |
0 |
4250000 |
0 |
10 |
4250000 |
5.9 % |
08/11/2021 |
| Camber Capital
Management LP
42-1693587 |
|
0 |
4250000 |
0 |
4250000 |
4250000 |
5.9 % |
08/11/2021 |
| Camber Capital
Management LP
42-1693587 |
or Place of Organization |
0 |
4250000 |
0 |
10 |
4250000 |
5.9 % |
08/11/2021 |
| Camber Capital Management LP |
Delaware |
0 |
4250000 |
0 |
4250000 |
2013 |
5.91 % |
29/07/2021 |
| American Capital Management, Inc. |
New York |
18828 |
0 |
4308685 |
0 |
4308685 |
6.01 % |
16/02/2021 |
| American Capital Management, Inc. |
New York |
18828 |
0 |
4308685 |
0 |
4308685 |
6.01 % |
16/02/2021 |
| 30-0447847 |
Delaware |
2809599 |
0 |
2950942 |
0 |
2950942 |
4.1 % |
12/02/2021 |
| 30-0447847 |
Delaware |
2809599 |
0 |
2950942 |
0 |
2950942 |
4.1 % |
12/02/2021 |
| 13-3127734 |
Delaware |
1158703 |
0 |
1158703 |
0 |
1158703 |
1.62 % |
10/02/2021 |
| 26-0385758 |
Delaware |
1158703 |
0 |
1158703 |
0 |
1158703 |
1.62 % |
10/02/2021 |
| 26-0385758 |
Delaware |
1158703 |
0 |
1158703 |
0 |
1158703 |
1.62 % |
10/02/2021 |
| 13-3127734 |
Delaware |
1158703 |
0 |
1158703 |
0 |
1158703 |
1.62 % |
10/02/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
1054330 |
0 |
0 |
1134700 |
1.58 % |
04/02/2021 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
1054330 |
0 |
0 |
1134700 |
1.58 % |
04/02/2021 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
1054330 |
0 |
0 |
1134700 |
1.58 % |
04/02/2021 |
| MANAGED ACCOUNT ADVISORS LLC00-0000000 |
Delaware |
0 |
0 |
3941924 |
7980 |
3949904 |
5.5 % |
03/02/2021 |
| MANAGED ACCOUNT ADVISORS LLC00-0000000 |
Delaware |
0 |
0 |
3941924 |
7980 |
3949904 |
5.5 % |
03/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
10897737 |
0 |
11031726 |
0 |
11031726 |
15.4 % |
25/01/2021 |
| Deerfield Partners, L.P. |
Delaware |
0 |
3471600 |
0 |
0 |
3471600 |
4.85 % |
10/08/2020 |
| James E. Flynn |
Delaware |
0 |
3471600 |
0 |
0 |
3471600 |
4.85 % |
10/08/2020 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
3471600 |
0 |
0 |
3471600 |
4.85 % |
10/08/2020 |
| James E. Flynn |
United States |
0 |
3471600 |
0 |
0 |
3471600 |
4.85 % |
10/08/2020 |
| Company, L.P. |
Delaware |
0 |
3471600 |
0 |
0 |
3471600 |
4.85 % |
10/08/2020 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
3471600 |
0 |
0 |
3471600 |
4.85 % |
10/08/2020 |
| Deerfield Partners, L.P. |
Delaware |
0 |
3471600 |
0 |
0 |
3471600 |
4.85 % |
10/08/2020 |
| Company, L.P. |
Delaware |
0 |
3471600 |
0 |
0 |
3471600 |
4.85 % |
10/08/2020 |
| American Capital Management, Inc. |
New York |
8090 |
0 |
3158570 |
0 |
3158570 |
5.12 % |
20/02/2020 |
| American Capital Management, Inc. |
New York |
8090 |
0 |
3158570 |
0 |
3158570 |
5.12 % |
20/02/2020 |
| 26-0385758 |
Delaware |
4156716 |
0 |
4157489 |
32324 |
4189813 |
6.79 % |
13/02/2020 |
| (. |
Delaware |
3146907 |
0 |
3315416 |
0 |
3315416 |
5.37 % |
12/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
9715576 |
0 |
9852763 |
0 |
9852763 |
16 % |
04/02/2020 |
| Wellington Management Company LLP |
Massachusetts |
0 |
3044411 |
0 |
0 |
3464475 |
5.61 % |
28/01/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3044411 |
0 |
3578821 |
3578821 |
5.8 % |
28/01/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3044411 |
0 |
0 |
3578821 |
5.8 % |
28/01/2020 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
3044411 |
0 |
0 |
3578821 |
5.8 % |
28/01/2020 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
3044411 |
0 |
0 |
3578821 |
5.8 % |
28/01/2020 |
| Mariko O. Gordon |
USA |
0 |
847286 |
0 |
0 |
1628360 |
2.66 % |
14/02/2019 |
| Daruma Capital Management, LLC |
Delaware |
0 |
847286 |
0 |
0 |
1628360 |
2.66 % |
14/02/2019 |
| Mariko O. Gordon |
Delaware |
0 |
847286 |
0 |
0 |
1628360 |
2.66 % |
14/02/2019 |
| Daruma Capital Management, LLC |
Delaware |
0 |
847286 |
0 |
0 |
1628360 |
2.66 % |
14/02/2019 |
| Fred Alger Management, Inc. |
New York |
3407426 |
0 |
3407426 |
0 |
3407426 |
5.56 % |
14/02/2019 |
| Fred Alger & Company, Incorporated – 13-2665689 |
New York |
3407426 |
0 |
3407426 |
0 |
3407426 |
5.56 % |
14/02/2019 |
| Alger Associates, Inc. 13-3017981 |
New York |
3407426 |
0 |
3407426 |
0 |
3407426 |
5.56 % |
14/02/2019 |
| Fred Alger Management, Inc. |
New York |
3407426 |
0 |
3407426 |
0 |
3407426 |
5.56 % |
14/02/2019 |
| Fred Alger & Company, Incorporated – 13-2665689 |
New York |
3407426 |
0 |
3407426 |
0 |
3407426 |
5.56 % |
14/02/2019 |
| Alger Associates, Inc. 13-3017981 |
New York |
3407426 |
0 |
3407426 |
0 |
3407426 |
5.56 % |
14/02/2019 |
| (1) BlackRock, Inc. |
Delaware |
8771335 |
0 |
8902252 |
0 |
8902252 |
14.5 % |
31/01/2019 |
| Wellington Management Group LLP |
Massachusetts |
0 |
1728301 |
0 |
0 |
1975495 |
3.23 % |
10/12/2018 |
| Wellington Group Holdings LLP |
Delaware |
0 |
1728301 |
0 |
0 |
1975495 |
3.23 % |
10/12/2018 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
1728301 |
0 |
0 |
1975495 |
3.23 % |
10/12/2018 |
| Mariko O. Gordon |
Delaware |
0 |
1320990 |
0 |
0 |
3038215 |
5.01 % |
14/02/2018 |
| Daruma Capital Management, LLC |
Delaware |
0 |
1320990 |
0 |
0 |
3038215 |
5.01 % |
14/02/2018 |
| Mariko O. Gordon |
USA |
0 |
1320990 |
0 |
0 |
3038215 |
5.01 % |
14/02/2018 |
| Daruma Capital Management, LLC |
Delaware |
0 |
1320990 |
0 |
0 |
3038215 |
5.01 % |
14/02/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2976004 |
0 |
0 |
3286266 |
5.42 % |
08/02/2018 |
| Wellington Management Company LLP |
Delaware |
0 |
2955104 |
0 |
0 |
3138227 |
5.17 % |
08/02/2018 |
| Wellington Management Company LLP |
Massachusetts |
0 |
2955104 |
0 |
0 |
3138227 |
5.17 % |
08/02/2018 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
2976004 |
0 |
0 |
3286266 |
5.42 % |
08/02/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2976004 |
0 |
0 |
3286266 |
5.42 % |
08/02/2018 |
| Wellington Group Holdings LLP |
Delaware |
0 |
2976004 |
0 |
0 |
3286266 |
5.42 % |
08/02/2018 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2976004 |
0 |
0 |
3286266 |
5.42 % |
08/02/2018 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
2976004 |
0 |
0 |
3286266 |
5.42 % |
08/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
7621532 |
0 |
7729515 |
0 |
7729515 |
12.7 % |
19/01/2018 |
| 13-3127734 |
Delaware |
4023301 |
0 |
4197303 |
0 |
4197303 |
7.53 % |
14/02/2017 |
| 26-0385758 |
Delaware |
4023301 |
0 |
4197303 |
0 |
4197303 |
7.53 % |
14/02/2017 |
| 13-3127734 |
Delaware |
4023301 |
0 |
4197303 |
0 |
4197303 |
7.53 % |
14/02/2017 |
| 26-0385758 |
Delaware |
4023301 |
0 |
4197303 |
0 |
4197303 |
7.53 % |
14/02/2017 |
| BARCLAYS GLOBAL INVESTORS, NA. |
Pennsylvania |
106632 |
4900 |
3320228 |
108832 |
2628711 |
4.89 % |
10/02/2017 |
| The Vanguard Group |
Pennsylvania |
106632 |
4900 |
3320228 |
108832 |
4135323 |
5.33 % |
10/02/2017 |
| (1) BlackRock, Inc. |
Delaware |
5241380 |
0 |
5359573 |
0 |
5359573 |
9.6 % |
25/01/2017 |
| (1) BlackRock, Inc. |
Delaware |
5058351 |
0 |
5235675 |
0 |
5235675 |
9.3 % |
27/01/2016 |
| Wells Capital Management Incorporated |
California |
0 |
2616797 |
0 |
0 |
10520761 |
19.04 % |
29/03/2013 |
| Wells Fargo Funds Management, LLC |
Delaware |
0 |
8015163 |
0 |
0 |
8015163 |
14.5 % |
29/03/2013 |
| Wells Fargo & Company |
Delaware |
0 |
10534813 |
0 |
0 |
10646014 |
19.26 % |
29/03/2013 |
| 04-3542621 |
Delaware |
6906 |
0 |
2800702 |
0 |
2800702 |
5.9 % |
14/02/2012 |
| 04-3543039 |
Delaware |
219180 |
0 |
234306 |
0 |
234306 |
0.5 % |
14/02/2012 |
| 26-1080669 |
Delaware |
226086 |
0 |
3035008 |
0 |
3035008 |
6.4 % |
14/02/2012 |
| OrbiMed Capital LLC |
Delaware |
0 |
1672300 |
0 |
1672300 |
1672300 |
11 % |
14/02/2012 |
| OrbiMed Capital LLC |
Delaware |
0 |
1672300 |
0 |
1672300 |
1672300 |
11 % |
14/02/2012 |
| OrbiMed Advisors LLC |
Delaware |
0 |
1236600 |
0 |
1236600 |
1236600 |
11 % |
14/02/2012 |
| Samuel D. Isaly |
Delaware |
0 |
2908900 |
0 |
2908900 |
2908900 |
11 % |
14/02/2012 |
| Samuel D. Isaly |
Delaware |
0 |
2908900 |
0 |
2908900 |
2908900 |
11 % |
14/02/2012 |
| OrbiMed Advisors LLC |
Delaware |
0 |
1236600 |
0 |
1236600 |
1236600 |
11 % |
14/02/2012 |
| HealthCor Capital, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2011 |
| HealthCor Group, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2011 |
| Joseph Healey |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2011 |
| HealthCor Hybrid Offshore GP, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2011 |
| Arthur Cohen |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2011 |
| HealthCor Associates, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2011 |
| HealthCor Hybrid Offshore Master Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2011 |
| HealthCor Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2011 |
| HealthCor Offshore, Ltd. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2011 |
| HealthCor Offshore Master Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2011 |
| HealthCor Offshore GP, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2011 |
| HealthCor Hybrid Offshore, Ltd. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2011 |
| HealthCor, L.P |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/02/2011 |
| HealthCor Offshore GP, LLC |
Cayman Islands |
0 |
13 |
0 |
13 |
1501230 |
3.27 % |
11/02/2010 |
| Joseph Healey |
Cayman Islands |
0 |
2525000 |
0 |
13 |
2525000 |
5.5 % |
11/02/2010 |
| Arthur Cohen |
Cayman Islands |
0 |
2525000 |
0 |
13 |
2525000 |
5.5 % |
11/02/2010 |
| HealthCor, L.P. |
Cayman Islands |
0 |
681125 |
0 |
13 |
681125 |
1.48 % |
11/02/2010 |
| HealthCor Capital, L.P. |
Cayman Islands |
0 |
681125 |
0 |
13 |
681125 |
1.48 % |
11/02/2010 |
| HealthCor Hybrid Offshore GP, LLC |
Cayman Islands |
0 |
342645 |
0 |
13 |
342645 |
0.75 % |
11/02/2010 |
| HealthCor Hybrid Offshore Master Fund, L.P. |
Cayman Islands |
0 |
342645 |
0 |
13 |
342645 |
0.75 % |
11/02/2010 |
| HealthCor Hybrid Offshore, Ltd. |
Cayman Islands |
0 |
0 |
0 |
13 |
342645 |
0.75 % |
11/02/2010 |
| HealthCor Offshore Master Fund, L.P. |
Cayman Islands |
13 |
1501230 |
0 |
13 |
1501230 |
3.27 % |
11/02/2010 |
| HealthCor Offshore, Ltd. |
Cayman Islands |
0 |
1501230 |
0 |
13 |
1501230 |
3.27 % |
11/02/2010 |
| HealthCor Associates, LLC |
Cayman Islands |
0 |
2525000 |
0 |
13 |
2525000 |
5.5 % |
11/02/2010 |
| HealthCor Group, LLC |
Cayman Islands |
0 |
2525000 |
0 |
13 |
2525000 |
5.5 % |
11/02/2010 |
| HealthCor Management, L.P. |
Cayman Islands |
0 |
2525000 |
0 |
13 |
2525000 |
5.5 % |
11/02/2010 |
| (1) BlackRock, Inc. |
Delaware |
5961659 |
0 |
5961659 |
0 |
5961659 |
12.98 % |
08/01/2010 |
| Wells Fargo and Company |
Delaware |
7127175 |
0 |
7185657 |
0 |
7202827 |
15.7 % |
30/04/2009 |
| Wells Capital Management Inc |
California |
1578428 |
0 |
7063101 |
0 |
7063101 |
15.4 % |
30/04/2009 |
| Wells Fargo Funds Management, LLC |
Delaware |
5546022 |
0 |
121456 |
0 |
5546022 |
12.09 % |
30/04/2009 |
| Manning & Napier |
New York |
2643216 |
0 |
2655536 |
0 |
2655536 |
5.79 % |
12/02/2009 |
| 13-1957714 |
New York |
0 |
0 |
0 |
0 |
3318100 |
11 % |
10/02/2009 |
| 13-4046559 |
Delaware |
0 |
2569248 |
0 |
0 |
2569248 |
5.5 % |
21/05/2008 |
| 13-3695715 |
Delaware |
0 |
2569305 |
0 |
0 |
2569305 |
5.5 % |
21/05/2008 |
| E. Shaw |
States |
0 |
2569305 |
0 |
2569305 |
2569305 |
5.5 % |
21/05/2008 |
| 13-1957714 |
New York |
0 |
0 |
0 |
0 |
3528500 |
11 % |
13/02/2008 |
| Wells Capital Management Incorporated |
California |
1516611 |
0 |
7074595 |
0 |
7074595 |
15.18 % |
22/01/2008 |
| Wells Fargo & Company |
Delaware |
7164897 |
0 |
7255119 |
0 |
7227244 |
15.5 % |
22/01/2008 |
| Wells Fargo Funds Management, LLC |
Delaware |
5646661 |
0 |
150524 |
0 |
5646661 |
12.11 % |
22/01/2008 |
| 13-1957714 |
New York |
0 |
0 |
0 |
0 |
3338600 |
11 % |
12/02/2007 |
| MASTER VALUE OPPORTUNITIES TRUST |
NUMBER OF SHARES BENEFICALLY OWNED BY EACH REPORTING PERSON WITH |
0 |
3808500 |
0 |
3808500 |
3808500 |
8.3 % |
09/06/2006 |
| (on behalf of Merrill Lynch Investment Managers (MLIM"))** |
NUMBER OF SHARES BENEFICALLY OWNED BY EACH REPORTING PERSON WITH |
0 |
5005828 |
0 |
5005828 |
5005828 |
10.91 % |
09/06/2006 |
| MASTER VALUE OPPORTUNITIES TRUST |
NUMBER OF SHARES BENEFICALLY OWNED BY EACH REPORTING PERSON WITH |
0 |
2704300 |
0 |
2704300 |
2704300 |
5.94 % |
02/03/2006 |
| (on behalf of Merrill Lynch Investment Managers (MLIM"))** |
NUMBER OF SHARES BENEFICALLY OWNED BY EACH REPORTING PERSON WITH |
0 |
2752628 |
0 |
2752628 |
2752628 |
6.05 % |
02/03/2006 |
| Federal ID No. 95-3692822 |
California |
772485 |
0 |
3831742 |
0 |
3831742 |
8.42 % |
15/02/2006 |
| Wells Fargo & Company |
Delaware |
3903467 |
0 |
3936924 |
2500 |
3939424 |
8.65 % |
15/02/2006 |
| Federal ID No. 94-3382001 |
Delaware |
3128982 |
0 |
105182 |
0 |
3128982 |
6.87 % |
15/02/2006 |
| (on behalf of Merrill Lynch Investment Managers (MLIM"))** |
NUMBER OF SHARES BENEFICALLY OWNED BY EACH REPORTING PERSON WITH |
0 |
2752628 |
0 |
2752628 |
2752628 |
6.05 % |
07/02/2006 |
| Augustine Lawlor |
United States |
840 |
1230754 |
840 |
1230754 |
1231594 |
2.8 % |
17/02/2004 |
| Christopher Mirabelli, Ph.D. |
United States |
1679 |
1230754 |
1679 |
1230754 |
1232433 |
2.8 % |
17/02/2004 |
| Harold R. Werner |
United States |
17314 |
1230754 |
17314 |
1230754 |
1248068 |
2.8 % |
17/02/2004 |
| William Crouse |
United States |
139747 |
1230754 |
139747 |
1230754 |
1370501 |
3.1 % |
17/02/2004 |
| HealthCare Ventures V, L.P. |
Delaware |
0 |
1230754 |
0 |
1230754 |
1230754 |
2.8 % |
17/02/2004 |
| HealthCare Partners V, L.P. |
Delaware |
0 |
1230754 |
0 |
1230754 |
1230754 |
2.8 % |
17/02/2004 |
| James H. Cavanaugh, Ph.D. |
United States |
14814 |
1230754 |
14814 |
1230754 |
1245568 |
2.8 % |
17/02/2004 |
| John W. Littlechild |
United States |
18103 |
1230754 |
18103 |
1230754 |
1256747 |
2.9 % |
17/02/2004 |
| Christopher Mirabelli |
United States |
0 |
3115298 |
0 |
3115298 |
3115298 |
8.57 % |
06/10/2000 |
| Harold Werner |
United States |
0 |
3115298 |
0 |
3115298 |
3115298 |
8.57 % |
06/10/2000 |
| John Littlechild |
United States |
0 |
3115298 |
0 |
3115298 |
3115298 |
8.57 % |
06/10/2000 |
| Augustine Lawlor |
United States |
0 |
3115298 |
0 |
3115298 |
3115298 |
8.57 % |
06/10/2000 |
| William Crouse |
United States |
7944 |
3115298 |
7944 |
3115298 |
3123242 |
8.59 % |
06/10/2000 |
| HealthCare Partners V, L.P. |
Delaware |
0 |
3115298 |
0 |
3115298 |
3115298 |
8.57 % |
06/10/2000 |
| James H. Cavanaugh, Ph.D. |
United States |
0 |
3115298 |
0 |
3115298 |
3115298 |
8.57 % |
06/10/2000 |
| HealthCare Ventures V, L.P. |
Delaware |
0 |
3115298 |
0 |
3115298 |
3115298 |
8.57 % |
06/10/2000 |