| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
3741201 |
0 |
3822434 |
0 |
3822434 |
7.1 % |
14/11/2024 |
| Todd W. Fennell |
Florida |
0 |
3168827 |
0 |
3168827 |
3168827 |
5.89 % |
13/11/2024 |
| William P. Scully |
Florida |
694313 |
3341827 |
694313 |
3341827 |
4036140 |
7.5 % |
13/11/2024 |
| Wellington Group Holdings LLP |
Delaware |
0 |
4119120 |
0 |
4178788 |
4178788 |
7.77 % |
08/11/2024 |
| Wellington Management Company LLP |
Delaware |
0 |
4115266 |
0 |
4148045 |
4148045 |
7.71 % |
08/11/2024 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4119120 |
0 |
4178788 |
4178788 |
7.77 % |
08/11/2024 |
| Wellington Management Group LLP |
Massachusetts |
0 |
4119120 |
0 |
4178788 |
4178788 |
7.77 % |
08/11/2024 |
| Wellington Management Group LLP |
Massachusetts |
0 |
5703802 |
0 |
5798741 |
5798741 |
10.78 % |
07/11/2024 |
| Wellington Group Holdings LLP |
Delaware |
0 |
5703802 |
0 |
5798741 |
5798741 |
10.78 % |
07/11/2024 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
5703802 |
0 |
5798741 |
5798741 |
10.78 % |
07/11/2024 |
| Wellington Management Company LLP |
Delaware |
0 |
5699948 |
0 |
5757193 |
5757193 |
10.71 % |
07/11/2024 |
| STATE STREET CORPORATION |
MA |
0 |
1540883 |
0 |
1674909 |
1674909 |
3.1 % |
18/10/2024 |
| William P. Scully |
Florida |
349022 |
3153459 |
349022 |
3153459 |
3502481 |
6.53 % |
14/02/2024 |
| FMR LLC |
Delaware |
8049190 |
0 |
8049796 |
0 |
8049796 |
14.999 % |
09/02/2024 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
8049796 |
0 |
8049796 |
14.999 % |
09/02/2024 |
| BlackRock, Inc. |
Delaware |
3684648 |
0 |
3770650 |
0 |
3770650 |
7 % |
02/02/2024 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
2641813 |
0 |
2758564 |
2758564 |
5.14 % |
24/01/2024 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
5264847 |
0 |
5264847 |
10.015 % |
10/03/2023 |
| FMR LLC |
Delaware |
5264223 |
0 |
5264847 |
0 |
5264847 |
10.015 % |
10/03/2023 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
5264847 |
0 |
5264847 |
10.015 % |
10/03/2023 |
| FMR LLC |
Delaware |
5264223 |
0 |
5264847 |
0 |
5264847 |
10.015 % |
10/03/2023 |
| William P. Scully |
Florida |
316000 |
2147000 |
316000 |
2147000 |
2463000 |
4.82 % |
14/02/2023 |
| William P. Scully |
Florida |
316000 |
2147000 |
316000 |
2147000 |
2463000 |
4.82 % |
14/02/2023 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
588569 |
0 |
3205903 |
0 |
3205903 |
6.3 % |
14/02/2023 |
| BlackRock, Inc. |
Delaware |
3444913 |
0 |
3485068 |
0 |
3485068 |
6.8 % |
31/01/2023 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
556042 |
0 |
3007511 |
0 |
3007511 |
6.4 % |
10/08/2022 |
| William P. Scully |
Florida |
353500 |
2177000 |
353500 |
2177000 |
2530500 |
5.41 % |
27/06/2022 |
| Mathew P. Arens |
United State of America |
0 |
1805038 |
0 |
1805038 |
1805038 |
3.87 % |
01/03/2022 |
| First Light Asset Management, LLC |
Delaware |
0 |
1805038 |
0 |
1805038 |
1805038 |
3.87 % |
01/03/2022 |
| Mathew P. Arens |
United State of America |
0 |
1805038 |
0 |
1805038 |
1805038 |
3.87 % |
01/03/2022 |
| First Light Asset Management, LLC |
Delaware |
0 |
1805038 |
0 |
1805038 |
1805038 |
3.87 % |
01/03/2022 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
1305737 |
0 |
5948861 |
0 |
5948861 |
12.7 % |
14/02/2022 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
1305737 |
0 |
5948861 |
0 |
5948861 |
12.7 % |
14/02/2022 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
958591 |
0 |
5173608 |
0 |
5173608 |
11.7 % |
10/06/2021 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
958591 |
0 |
5173608 |
0 |
5173608 |
11.7 % |
10/06/2021 |
| Ft Light Asset Management, LLC S |
Delaware |
0 |
2929340 |
0 |
2929340 |
2929340 |
7.34 % |
16/02/2021 |
| Mathew P. Arens S |
United America |
0 |
2929340 |
0 |
2929340 |
2929340 |
7.34 % |
16/02/2021 |
| Mathew P. Arens |
United State of America |
0 |
2929340 |
0 |
2929340 |
2929340 |
7.34 % |
16/02/2021 |
| First Light Asset Management, LLC |
Delaware |
0 |
2929340 |
0 |
2929340 |
2929340 |
7.34 % |
16/02/2021 |
| Great Point Partners, LLC |
USA |
0 |
977647 |
0 |
977647 |
0 |
2.45 % |
16/02/2021 |
| Mr. Ortav Yehudai |
USA |
0 |
977647 |
0 |
977647 |
0 |
2.45 % |
16/02/2021 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
977647 |
0 |
977647 |
0 |
2.45 % |
16/02/2021 |
| Mr. Ortav Yehudai |
USA |
0 |
977647 |
0 |
977647 |
0 |
2.45 % |
16/02/2021 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
977647 |
0 |
977647 |
0 |
2.45 % |
16/02/2021 |
| Great Point Partners, LLC |
USA |
0 |
977647 |
0 |
977647 |
0 |
2.45 % |
16/02/2021 |
| OrbiMed Capital LLC |
Delaware |
1485458 |
|
1485458 |
|
1485458 |
3.72 % |
12/02/2021 |
| OrbiMed Advisors LLC |
Delaware |
0 |
312000 |
0 |
312000 |
312000 |
0.78 % |
12/02/2021 |
| OrbiMed Capital LLC |
Delaware |
1485458 |
|
1485458 |
|
1485458 |
3.72 % |
12/02/2021 |
| OrbiMed Advisors LLC |
Delaware |
0 |
312000 |
0 |
312000 |
312000 |
0.78 % |
12/02/2021 |
| Great Point Partners, LLC |
USA |
0 |
2100941 |
0 |
2100941 |
0 |
5.27 % |
14/02/2020 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2100941 |
0 |
2100941 |
0 |
5.27 % |
14/02/2020 |
| Mr. David Kroin |
USA |
0 |
2100941 |
0 |
2100941 |
0 |
5.27 % |
14/02/2020 |
| OrbiMed Advisors LLC |
Delaware |
0 |
613800 |
0 |
|
613800 |
1.54 % |
14/02/2020 |
| OrbiMed Capital LLC |
Delaware |
0 |
2288439 |
0 |
|
2288439 |
5.74 % |
14/02/2020 |
| FMR LLC |
Delaware |
1099268 |
0 |
3327349 |
0 |
3327349 |
8.339 % |
07/02/2020 |
| FMR LLC |
Delaware |
1099268 |
0 |
3327349 |
0 |
3327349 |
8.339 % |
07/02/2020 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
3327349 |
0 |
3327349 |
8.339 % |
07/02/2020 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
3327349 |
0 |
3327349 |
8.339 % |
07/02/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
951858 |
0 |
973900 |
973900 |
2.44 % |
28/01/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
951858 |
0 |
973900 |
973900 |
2.44 % |
28/01/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
951858 |
0 |
973900 |
973900 |
2.44 % |
28/01/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
951858 |
0 |
973900 |
973900 |
2.44 % |
28/01/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
951858 |
0 |
973900 |
973900 |
2.44 % |
28/01/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
951858 |
0 |
973900 |
973900 |
2.44 % |
28/01/2020 |
| Woodford Investment Management Ltd |
United Kingdom |
0 |
0 |
0 |
0 |
0 |
0 % |
09/09/2019 |
| Woodford Investment Management Ltd |
United Kingdom |
0 |
0 |
0 |
0 |
0 |
0 % |
09/09/2019 |
| Neil Woodford |
United Kingdom |
0 |
0 |
0 |
0 |
0 |
0 % |
09/09/2019 |
| Neil Woodford |
United Kingdom |
0 |
0 |
0 |
0 |
0 |
0 % |
09/09/2019 |
| LF Woodford Equity Income Fund |
United Kingdom |
0 |
0 |
0 |
0 |
0 |
0 % |
09/09/2019 |
| Great Point Partners, LLC |
USA |
0 |
2066041 |
0 |
2066041 |
2066041 |
5.18 % |
05/08/2019 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2066041 |
0 |
2066041 |
2066041 |
5.18 % |
05/08/2019 |
| Mr. David Kroin |
USA |
0 |
2066041 |
0 |
2066041 |
2066041 |
5.18 % |
05/08/2019 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2066041 |
0 |
2066041 |
2066041 |
5.18 % |
05/08/2019 |
| Mr. David Kroin |
USA |
0 |
2066041 |
0 |
2066041 |
2066041 |
5.18 % |
05/08/2019 |
| Great Point Partners, LLC |
USA |
0 |
2066041 |
0 |
2066041 |
2066041 |
5.18 % |
05/08/2019 |
| Woodford Investment Management Ltd |
United Kingdom |
0 |
8773790 |
0 |
8773790 |
8773790 |
22 % |
09/07/2019 |
| Neil Woodford |
United Kingdom |
0 |
8773790 |
0 |
8773790 |
8773790 |
22 % |
09/07/2019 |
| Neil Woodford |
United Kingdom |
0 |
8773790 |
0 |
8773790 |
8773790 |
22 % |
09/07/2019 |
| Woodford Investment Management Ltd |
United Kingdom |
0 |
8773790 |
0 |
8773790 |
8773790 |
22 % |
09/07/2019 |
| Woodford Patient Capital Trust Plc |
United Kingdom |
0 |
0 |
0 |
0 |
0 |
0 % |
09/07/2019 |
| Scopia Capital Management LP |
Delaware |
0 |
1883816 |
0 |
1883816 |
1883816 |
4.7 % |
11/03/2019 |
| Matthew Sirovich |
United States |
0 |
1883816 |
0 |
1883816 |
1883816 |
4.7 % |
11/03/2019 |
| Jeremy Mindich |
United States |
0 |
1883816 |
0 |
1883816 |
1883816 |
4.7 % |
11/03/2019 |
| Scopia Management, Inc. |
New York |
0 |
1883816 |
0 |
1883816 |
1883816 |
4.7 % |
11/03/2019 |
| Jeremy Mindich |
United States |
0 |
1883816 |
0 |
1883816 |
1883816 |
4.7 % |
11/03/2019 |
| Matthew Sirovich |
United States |
0 |
1883816 |
0 |
1883816 |
1883816 |
4.7 % |
11/03/2019 |
| Scopia Capital Management LP |
Delaware |
0 |
1883816 |
0 |
1883816 |
1883816 |
4.7 % |
11/03/2019 |
| Scopia Management, Inc. |
New York |
0 |
1883816 |
0 |
1883816 |
1883816 |
4.7 % |
11/03/2019 |
| Neil Woodford |
United Kingdom |
0 |
11058198 |
0 |
11924614 |
11924614 |
29.9 % |
14/02/2019 |
| Woodford Investment Management Ltd |
United Kingdom |
0 |
11058198 |
0 |
11924614 |
11924614 |
29.9 % |
14/02/2019 |
| FMR LLC |
Delaware |
1342429 |
0 |
4910430 |
0 |
4910430 |
12.318 % |
13/02/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
4910430 |
0 |
4910430 |
12.318 % |
13/02/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
4910430 |
0 |
4910430 |
12.318 % |
13/02/2019 |
| FMR LLC |
Delaware |
1342429 |
0 |
4910430 |
0 |
4910430 |
12.318 % |
13/02/2019 |
| VANGUARD SPECIALIZED FUNDS VANGUARD HEALTH CARE FUND |
Delaware |
920628 |
|
0 |
0 |
920628 |
2.3 % |
31/01/2019 |
| Matthew Sirovich |
United States |
0 |
4618164 |
0 |
4618164 |
4618164 |
11.6 % |
10/01/2019 |
| Scopia Management, Inc. |
New York |
0 |
4618164 |
0 |
4618164 |
4618164 |
11.6 % |
10/01/2019 |
| Scopia Capital Management LP |
Delaware |
0 |
4618164 |
0 |
4618164 |
4618164 |
11.6 % |
10/01/2019 |
| Matthew Sirovich |
United States |
0 |
4618164 |
0 |
4618164 |
4618164 |
11.6 % |
10/01/2019 |
| Scopia Management, Inc. |
New York |
0 |
4618164 |
0 |
4618164 |
4618164 |
11.6 % |
10/01/2019 |
| Scopia Capital Management LP |
Delaware |
0 |
4618164 |
0 |
4618164 |
4618164 |
11.6 % |
10/01/2019 |
| Jeremy Mindich |
United States |
0 |
4618164 |
0 |
4618164 |
4618164 |
11.6 % |
10/01/2019 |
| Jeremy Mindich |
United States |
0 |
4618164 |
0 |
4618164 |
4618164 |
11.6 % |
10/01/2019 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
219079 |
0 |
1516638 |
0 |
1516638 |
3.8 % |
10/05/2018 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
219079 |
0 |
1516638 |
0 |
1516638 |
3.8 % |
10/05/2018 |
| Woodford Patient Capital Trust |
United Kingdom |
0 |
2550408 |
0 |
2550408 |
2550408 |
6.6 % |
13/02/2018 |
| Wellington Group Holdings LLP |
Delaware |
0 |
998501 |
0 |
3221394 |
3221394 |
8.38 % |
08/02/2018 |
| Wellington Management Company LLP |
Delaware |
0 |
985893 |
0 |
3155978 |
3155978 |
8.21 % |
08/02/2018 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
998501 |
0 |
3221394 |
3221394 |
8.38 % |
08/02/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
998501 |
0 |
3221394 |
3221394 |
8.38 % |
08/02/2018 |
| VANGUARD SPECIALIZED FUNDS VANGUARD HEALTH CARE FUND |
Delaware |
2150294 |
|
0 |
0 |
2150294 |
5.59 % |
02/02/2018 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
1053455 |
0 |
6103759 |
0 |
6103759 |
15.8 % |
10/01/2018 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
1053455 |
0 |
6103759 |
0 |
6103759 |
15.8 % |
10/01/2018 |
| Wellington Management Company LLP |
Delaware |
0 |
790544 |
0 |
2960558 |
2960558 |
8.58 % |
09/02/2017 |
| Wellington Management Group LLP |
Massachusetts |
0 |
790544 |
0 |
3019033 |
3019033 |
8.75 % |
09/02/2017 |
| Wellington Group Holdings LLP |
Delaware |
0 |
790544 |
0 |
3019033 |
3019033 |
8.75 % |
09/02/2017 |
| Wellington Group Holdings LLP |
Delaware |
0 |
790544 |
0 |
3019033 |
3019033 |
8.75 % |
09/02/2017 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
790544 |
0 |
3019033 |
3019033 |
8.75 % |
09/02/2017 |
| Wellington Management Group LLP |
Massachusetts |
0 |
790544 |
0 |
3019033 |
3019033 |
8.75 % |
09/02/2017 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
790544 |
0 |
3019033 |
3019033 |
8.75 % |
09/02/2017 |
| Wellington Management Company LLP |
Delaware |
0 |
790544 |
0 |
2960558 |
2960558 |
8.58 % |
09/02/2017 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
432531 |
0 |
3315177 |
0 |
3315177 |
9.6 % |
07/02/2017 |
| T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
3514610 |
10.1 % |
12/12/2016 |
| T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
3514610 |
10.1 % |
12/12/2016 |
| Neil Woodford |
United Kingdom |
0 |
8943700 |
0 |
9296361 |
9296361 |
27.1 % |
20/05/2016 |
| Woodford Investment Management LLP |
United Kingdom |
0 |
8943700 |
0 |
9296361 |
9296361 |
27.1 % |
20/05/2016 |
| Neil Woodford |
United Kingdom |
0 |
8943700 |
0 |
9296361 |
9296361 |
27.1 % |
20/05/2016 |
| Woodford Investment Management LLP |
United Kingdom |
0 |
8943700 |
0 |
9296361 |
9296361 |
27.1 % |
20/05/2016 |
| Woodford Investment Management LLP |
United Kingdom |
0 |
6199000 |
0 |
6379661 |
6379661 |
20.2 % |
19/02/2016 |
| Neil Woodford |
United Kingdom |
0 |
6199000 |
0 |
6379661 |
6379661 |
20.2 % |
19/02/2016 |
| Woodford Investment Management LLP |
United Kingdom |
0 |
6199000 |
0 |
6379661 |
6379661 |
20.2 % |
19/02/2016 |
| Neil Woodford |
United Kingdom |
0 |
6199000 |
0 |
6379661 |
6379661 |
20.2 % |
19/02/2016 |
| CF Woodford Equity Income Fund |
United Kingdom |
0 |
4934266 |
0 |
4934266 |
4934266 |
15.7 % |
19/02/2016 |
| T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
3100683 |
9.8 % |
08/02/2016 |
| T. ROWE PRICE HEALTH SCIENCES FUND, INC. |
Maryland |
0 |
0 |
0 |
0 |
1518310 |
4.8 % |
08/02/2016 |
| Woodford Investment Management LLP |
United Kingdom |
0 |
5852525 |
0 |
5852525 |
5852525 |
18.7 % |
09/09/2015 |
| Woodford Investment Management LLP |
United Kingdom |
0 |
5852525 |
0 |
5852525 |
5852525 |
18.7 % |
09/09/2015 |
| CF Woodford Equity Income Fund |
United Kingdom |
0 |
3022222 |
0 |
3022222 |
3022222 |
11 % |
07/04/2015 |
| Woodford Investment Management LLP |
United Kingdom |
0 |
3137363 |
0 |
3137363 |
3137363 |
10.3 % |
25/02/2015 |
| Woodford Investment Management LLP |
United Kingdom |
0 |
3137363 |
0 |
3137363 |
3137363 |
10.3 % |
25/02/2015 |
| RA Capital Management, LLC |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
| Peter Kolchinsky |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
| OrbiMed Advisors LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
| OrbiMed Capital LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
| Samuel D. Isaly |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
| VANGUARD SPECIALIZED FUNDS VANGUARD HEALTH CARE FUND |
Delaware For |
1662794 |
0 |
0 |
0 |
1662794 |
6.07 % |
06/02/2015 |
| Integrated Core Strategies (US) LLC |
|
|
|
|
|
716000 |
3.27 % |
07/03/2014 |
| Integrated Assets, Ltd. |
|
|
|
|
|
17476 |
0.08 % |
07/03/2014 |
| Millennium Management LLC |
|
|
|
|
|
1081538 |
4.94 % |
07/03/2014 |
| Millennium International Management GP LLC |
|
|
|
|
|
358509 |
1.64 % |
07/03/2014 |
| Israel A. Englander |
|
|
|
|
|
1081538 |
4.94 % |
07/03/2014 |
| Millennium Management LLC |
|
|
|
|
|
1081538 |
4.94 % |
07/03/2014 |
| Integrated Assets II LLC |
|
|
|
|
|
7029 |
0.03 % |
07/03/2014 |
| Millennium International Management GP LLC |
|
|
|
|
|
358509 |
1.64 % |
07/03/2014 |
| Israel A. Englander |
|
|
|
|
|
1081538 |
4.94 % |
07/03/2014 |
| Millennium International Management LP |
|
|
|
|
|
358509 |
1.64 % |
07/03/2014 |
| ICS Opportunities, Ltd. |
|
|
|
|
|
341033 |
1.56 % |
07/03/2014 |
| Integrated Assets II LLC |
|
|
|
|
|
7029 |
0.03 % |
07/03/2014 |
| Integrated Core Strategies (US) LLC |
|
|
|
|
|
716000 |
3.27 % |
07/03/2014 |
| Integrated Assets, Ltd. |
|
|
|
|
|
17476 |
0.08 % |
07/03/2014 |
| Millennium International Management LP |
|
|
|
|
|
358509 |
1.64 % |
07/03/2014 |
| ICS Opportunities, Ltd. |
|
|
|
|
|
341033 |
1.56 % |
07/03/2014 |
| Samuel D. Isaly |
United States |
0 |
1202000 |
0 |
1202000 |
1202000 |
5.5 % |
13/02/2014 |
| OrbiMed Advisors LLC |
Delaware |
0 |
413500 |
0 |
413500 |
413500 |
1.89 % |
13/02/2014 |
| OrbiMed Capital LLC |
Delaware |
0 |
788500 |
0 |
0 |
788500 |
3.61 % |
13/02/2014 |
| T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
1456806 |
6.6 % |
07/02/2014 |
| Johnson & Johnson |
New Jersey |
209421 |
0 |
209421 |
0 |
209421 |
1 % |
10/10/2013 |
| RA Capital Management, LLC |
Massachusetts |
0 |
1648599 |
0 |
1648599 |
1648599 |
9.3 % |
27/08/2013 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
1256714 |
0 |
1256714 |
1256714 |
7.1 % |
27/08/2013 |
| RA Capital Management, LLC |
Massachusetts |
0 |
1648599 |
0 |
1648599 |
1648599 |
9.3 % |
27/08/2013 |
| Peter Kolchinsky |
United States |
0 |
1648599 |
0 |
1648599 |
1648599 |
9.3 % |
27/08/2013 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
1256714 |
0 |
1256714 |
1256714 |
7.1 % |
27/08/2013 |
| Peter Kolchinsky |
United States |
0 |
1648599 |
0 |
1648599 |
1648599 |
9.3 % |
27/08/2013 |
| Wellington Management Company, LLP |
Massachusetts |
0 |
1201659 |
0 |
1531714 |
1531714 |
8.66 % |
07/08/2013 |
| Wellington Management Company, LLP |
Massachusetts |
0 |
1201659 |
0 |
1531714 |
1531714 |
8.66 % |
07/08/2013 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
1993988 |
0 |
1993988 |
11.279 % |
10/06/2013 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
1993988 |
0 |
1993988 |
11.279 % |
10/06/2013 |
| FMR LLC |
Delaware |
0 |
0 |
1993988 |
0 |
1993988 |
11.279 % |
10/06/2013 |
| FMR LLC |
Delaware |
0 |
0 |
1993988 |
0 |
1993988 |
11.279 % |
10/06/2013 |
| Wellington Management Company, LLP |
Massachusetts |
0 |
1152850 |
0 |
1727630 |
1727630 |
9.77 % |
14/02/2013 |
| Johnson & Johnson |
New Jersey |
2619421 |
0 |
2619421 |
0 |
2619421 |
14.82 % |
13/02/2013 |