PTGX

Protagonist Therapeutics, Inc. PTGX

Individual Beneficiary

Name of reporting person Citizenship or organization Sole voting power Shared voting power Sole dispositive power Shared dispositive power Amount beneficially owned Percent of class Accepted date
Biotechnology Value Fund II, L.P. Delaware 0 1240337 0 1240337 1240337 2.1 % 14/11/2024
Biotechnology Value Fund, L.P. Delaware 0 1522393 0 1522393 1522393 2.6 % 14/11/2024
BVF Partners L.P. Delaware 0 2970427 0 2970427 2970427 4.9 % 14/11/2024
BVF GP Holdings LLC Delaware 0 2762730 0 2762730 2762730 4.6 % 14/11/2024
BVF Partners OS Ltd. Cayman Islands 0 148998 0 148998 148998 0 % 14/11/2024
Biotechnology Value Trading Fund OS LP Cayman Islands 0 148998 0 148998 148998 0 % 14/11/2024
BVF II GP LLC Delaware 0 1240337 0 1240337 1240337 2.1 % 14/11/2024
BVF Inc. Delaware 0 2970427 0 2970427 2970427 4.9 % 14/11/2024
Mark N. Lampert United States 0 2970427 0 2970427 2970427 4.9 % 14/11/2024
BVF I GP LLC Delaware 0 1522393 0 1522393 1522393 2.6 % 14/11/2024
The Vanguard Group Pennsylvania 0 105584 4064443 151638 4216081 7.15 % 12/11/2024
The Vanguard Group Pennsylvania 0 105584 4064443 151638 4216081 7.15 % 04/11/2024
STATE STREET CORPORATION MA 0 3025575 0 3183542 3183542 5.4 % 16/10/2024
BlackRock, Inc. Delaware 10482080 0 10663695 0 10663695 18.2 % 07/08/2024
Citadel Advisors LLC Delaware 0 48 0 48 48 0 % 14/02/2024
Citadel Securities GP LLC Delaware 0 390464 0 390464 390464 0.7 % 14/02/2024
Kenneth Griffin U.S. Citizen 0 390512 0 390512 390512 0.7 % 14/02/2024
Citadel Securities Group LP Delaware 0 390464 0 390464 390464 0.7 % 14/02/2024
Citadel Advisors Holdings LP Delaware 0 48 0 48 48 0 % 14/02/2024
Citadel GP LLC Delaware 0 48 0 48 48 0 % 14/02/2024
Citadel Securities LLC Delaware 0 389203 0 389203 389203 0.7 % 14/02/2024
Mark N. Lampert United States 0 5763948 0 5763948 5763948 9.99 % 14/02/2024
Biotechnology Value Fund, L.P. Delaware 0 3120957 0 3120957 3120957 5.4 % 14/02/2024
BVF I GP LLC Delaware 0 3120957 0 3120957 3120957 5.4 % 14/02/2024
Biotechnology Value Fund II, L.P. Delaware 0 2344241 0 2344241 2344241 4.1 % 14/02/2024
BVF II GP LLC Delaware 0 2344241 0 2344241 2344241 4.1 % 14/02/2024
Biotechnology Value Trading Fund OS LP Cayman Islands 0 238712 0 238712 238712 0 % 14/02/2024
BVF Partners OS Ltd. Cayman Islands 0 238712 0 238712 238712 0 % 14/02/2024
BVF GP Holdings LLC Delaware 0 5465198 0 5465198 5465198 9.5 % 14/02/2024
BVF Partners L.P. Delaware 0 5763948 0 5763948 5763948 9.99 % 14/02/2024
BVF Inc. Delaware 0 5763948 0 5763948 5763948 9.99 % 14/02/2024
Roderick Wong, M.D. United States 0 5315514 0 5315514 5315514 9.2 % 14/02/2024
RTW Investments, LP Delaware 0 5315514 0 5315514 5315514 9.2 % 14/02/2024
Point72 Capital Advisors, Inc. Delaware 0 2613453 0 2613453 2613453 4.5 % 14/02/2024
Point72 Asset Management, L.P. Delaware 0 2613453 0 2613453 2613453 4.5 % 14/02/2024
Steven A. Cohen United States 0 2613453 0 2613453 2613453 4.5 % 14/02/2024
The Vanguard Group Pennsylvania 0 78615 3029991 123925 3153916 5.47 % 13/02/2024
Phillip Gross United States 0 1291701 0 1291701 1291701 2.24 % 07/02/2024
Adage Capital Partners GP, L.L.C. Delaware 0 1291701 0 1291701 1291701 2.24 % 07/02/2024
Robert Atchinson United States 0 1291701 0 1291701 1291701 2.24 % 07/02/2024
Robert Atchinson United States 0 1291701 0 1291701 1291701 2.24 % 07/02/2024
Adage Capital Advisors, L.L.C. Delaware 0 1291701 0 1291701 1291701 2.24 % 07/02/2024
Adage Capital Partners GP, L.L.C. Delaware 0 1291701 0 1291701 1291701 2.24 % 07/02/2024
Adage Capital Partners, L.P. Delaware 0 1291701 0 1291701 1291701 2.24 % 07/02/2024
Adage Capital Partners, L.P. Delaware 0 1291701 0 1291701 1291701 2.24 % 07/02/2024
Phillip Gross United States 0 1291701 0 1291701 1291701 2.24 % 07/02/2024
Adage Capital Advisors, L.L.C. Delaware 0 1291701 0 1291701 1291701 2.24 % 07/02/2024
BlackRock, Inc. Delaware 5458848 0 5543902 0 5543902 9.6 % 24/01/2024
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 2596274 0 2729929 2729929 4.73 % 23/01/2024
Point72 Capital Advisors, Inc. Delaware 0 3186077 0 3186077 3186077 5.5 % 18/12/2023
Steven A. Cohen United States 0 3186077 0 3186077 3186077 5.5 % 18/12/2023
Point72 Asset Management, L.P. Delaware 0 3186077 0 3186077 3186077 5.5 % 18/12/2023
Point72 Capital Advisors, Inc. Delaware 0 3186077 0 3186077 3186077 5.5 % 18/12/2023
Steven A. Cohen United States 0 3186077 0 3186077 3186077 5.5 % 18/12/2023
Point72 Asset Management, L.P. Delaware 0 3186077 0 3186077 3186077 5.5 % 18/12/2023
Adage Capital Advisors, L.L.C. Delaware 0 2955000 0 2955000 2955000 5.44 % 13/04/2023
Adage Capital Partners, L.P. Delaware 0 2955000 0 2955000 2955000 5.44 % 13/04/2023
Adage Capital Partners GP, L.L.C. Delaware 0 2955000 0 2955000 2955000 5.44 % 13/04/2023
Adage Capital Advisors, L.L.C. Delaware 0 2955000 0 2955000 2955000 5.44 % 13/04/2023
Adage Capital Partners GP, L.L.C. Delaware 0 2955000 0 2955000 2955000 5.44 % 13/04/2023
Phillip Gross United States 0 2955000 0 2955000 2955000 5.44 % 13/04/2023
Adage Capital Partners, L.P. Delaware 0 2955000 0 2955000 2955000 5.44 % 13/04/2023
Robert Atchinson United States 0 2955000 0 2955000 2955000 5.44 % 13/04/2023
Phillip Gross United States 0 2955000 0 2955000 2955000 5.44 % 13/04/2023
Robert Atchinson United States 0 2955000 0 2955000 2955000 5.44 % 13/04/2023
Biotechnology Value Trading Fund OS LP Cayman Islands 0 244980 0 244980 244980 0 % 20/03/2023
BVF II GP LLC Delaware 0 2005240 0 2005240 2005240 3.9 % 20/03/2023
Biotechnology Value Fund II, L.P. Delaware 0 2005240 0 2005240 2005240 3.9 % 20/03/2023
BVF Inc. Delaware 0 5025900 0 5025900 5025900 9.6 % 20/03/2023
Biotechnology Value Fund, L.P. Delaware 0 2630650 0 2630650 2630650 5.1 % 20/03/2023
BVF Inc. Delaware 0 5025900 0 5025900 5025900 9.6 % 20/03/2023
Mark N. Lampert United States 0 5025900 0 5025900 5025900 9.6 % 20/03/2023
Biotechnology Value Fund, L.P. Delaware 0 2630650 0 2630650 2630650 5.1 % 20/03/2023
BVF I GP LLC Delaware 0 2630650 0 2630650 2630650 5.1 % 20/03/2023
Biotechnology Value Fund II, L.P. Delaware 0 2005240 0 2005240 2005240 3.9 % 20/03/2023
BVF II GP LLC Delaware 0 2005240 0 2005240 2005240 3.9 % 20/03/2023
Biotechnology Value Trading Fund OS LP Cayman Islands 0 244980 0 244980 244980 0 % 20/03/2023
BVF Partners OS Ltd. Cayman Islands 0 244980 0 244980 244980 0 % 20/03/2023
BVF GP Holdings LLC Delaware 0 4635890 0 4635890 4635890 8.9 % 20/03/2023
BVF Partners L.P. Delaware 0 5025900 0 5025900 5025900 9.6 % 20/03/2023
Mark N. Lampert United States 0 5025900 0 5025900 5025900 9.6 % 20/03/2023
BVF Partners L.P. Delaware 0 5025900 0 5025900 5025900 9.6 % 20/03/2023
BVF GP Holdings LLC Delaware 0 4635890 0 4635890 4635890 8.9 % 20/03/2023
BVF Partners OS Ltd. Cayman Islands 0 244980 0 244980 244980 0 % 20/03/2023
BVF I GP LLC Delaware 0 2630650 0 2630650 2630650 5.1 % 20/03/2023
The Vanguard Group Pennsylvania For 0 38846 3023287 74427 3097714 6.3 % 09/02/2023
BlackRock, Inc. Delaware 3560703 0 3652157 0 3652157 7.4 % 31/01/2023
Johnson & Johnson Inc. New Jersey 0 2449183 0 2449183 2449183 4.98 % 11/01/2023
Johnson & Johnson New Jersey 0 2449183 0 2449183 2449183 4.98 % 11/01/2023
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 3706781 0 3792926 3792926 7.71 % 10/01/2023
SSGA FUNDS MANAGEMENT, INC. BOSTON, MASSACHUSETTS 0 2882021 0 2892121 2892121 5.88 % 10/01/2023
Citadel Securities Group LP Delaware 0 899294 0 899294 899294 1.8 % 03/01/2023
Citadel Advisors LLC Delaware 0 1783520 0 1783520 1783520 3.6 % 03/01/2023
Kenneth Griffin U.S. Citizen 0 2682814 0 2682814 2682814 5.5 % 03/01/2023
Citadel Advisors LLC Delaware 0 1783520 0 1783520 1783520 3.6 % 03/01/2023
Citadel Advisors Holdings LP Delaware 0 1783520 0 1783520 1783520 3.6 % 03/01/2023
Citadel GP LLC Delaware 0 1783520 0 1783520 1783520 3.6 % 03/01/2023
Citadel Securities LLC Delaware 0 502892 0 502892 502892 1 % 03/01/2023
Citadel Securities GP LLC Delaware 0 899294 0 899294 899294 1.8 % 03/01/2023
Kenneth Griffin U.S. Citizen 0 2682814 0 2682814 2682814 5.5 % 03/01/2023
Citadel Securities GP LLC Delaware 0 899294 0 899294 899294 1.8 % 03/01/2023
Citadel Securities Group LP Delaware 0 899294 0 899294 899294 1.8 % 03/01/2023
Citadel Securities LLC Delaware 0 502892 0 502892 502892 1 % 03/01/2023
Citadel GP LLC Delaware 0 1783520 0 1783520 1783520 3.6 % 03/01/2023
Citadel Advisors Holdings LP Delaware 0 1783520 0 1783520 1783520 3.6 % 03/01/2023
FMR LLC Delaware 384415 0 385863 0 385863 0.784 % 12/12/2022
Abigail P. Johnson United States of America 0 0 385863 0 385863 0.784 % 12/12/2022
FMR LLC Delaware 384415 0 385863 0 385863 0.784 % 12/12/2022
Abigail P. Johnson United States of America 0 0 385863 0 385863 0.784 % 12/12/2022
STATE STREET CORPORATION BOSTON, MASSACHUSETTS 0 6690429 0 6776269 6776269 13.93 % 11/07/2022
SSGA FUNDS MANAGEMENT, INC. BOSTON, MASSACHUSETTS 0 5930261 0 5940361 5940361 12.21 % 11/07/2022
Abigail P. Johnson United States of America 0 0 3554095 0 3554095 7.304 % 10/06/2022
FMR LLC Delaware 3553445 0 3554095 0 3554095 7.304 % 10/06/2022
FMR LLC Delaware 3553445 0 3554095 0 3554095 7.304 % 10/06/2022
Abigail P. Johnson United States of America 0 0 3554095 0 3554095 7.304 % 10/06/2022
Point72 Capital Advisors, Inc. Delaware 0 2419763 0 2419763 2419763 5.1 % 14/02/2022
Steven A. Cohen United States 0 2420309 0 2420309 2420309 5.1 % 14/02/2022
Cubist Systematic Strategies, LLC Delaware 0 546 0 546 546 0.1 % 14/02/2022
Point72 Asset Management, L.P. Delaware 0 2419763 0 2419763 2419763 5.1 % 14/02/2022
Point72 Hong Kong Limited Hong Kong 0 0 0 0 0 0 % 14/02/2022
Consonance Capman GP LLC Delaware USA 0 0 0 0 0 0 % 14/02/2022
Mitchell Blutt USA 0 0 0 0 0 0 % 14/02/2022
Consonance Capital Management LP Delaware USA 0 0 0 0 0 0 % 14/02/2022
Roderick Wong United States 0 2599822 0 2599822 2599822 5.4 % 14/02/2022
RTW Investments, LP Delaware 0 2599822 0 2599822 2599822 5.4 % 14/02/2022
BlackRock, Inc. Delaware 3241671 0 3281636 0 3281636 6.9 % 02/02/2022
Cubist Systematic Strategies, LLC Delaware 0 5571 0 5571 5571 0.1 % 21/09/2021
Point72 Asset Management, L.P. Delaware 0 4312300 0 4312300 4312300 9.1 % 21/09/2021
Point72 Asset Management, L.P. Delaware 0 4312300 0 4312300 4312300 9.1 % 21/09/2021
Steven A. Cohen United States 0 4329030 0 4329030 4329030 9.1 % 21/09/2021
Point72 Capital Advisors, Inc. Delaware 0 4312300 0 4312300 4312300 9.1 % 21/09/2021
Steven A. Cohen United States 0 4329030 0 4329030 4329030 9.1 % 21/09/2021
Point72 Hong Kong Limited Hong Kong 0 11159 0 11159 11159 0.1 % 21/09/2021
Cubist Systematic Strategies, LLC Delaware 0 5571 0 5571 5571 0.1 % 21/09/2021
Point72 Hong Kong Limited Hong Kong 0 11159 0 11159 11159 0.1 % 21/09/2021
Point72 Capital Advisors, Inc. Delaware 0 4312300 0 4312300 4312300 9.1 % 21/09/2021
Consonance Capital Opportunity Fund Management LP Delaware USA 0 268432 0 268432 268432 0.63 % 17/02/2021
Consonance Capman GP LLC Delaware USA 0 2729709 0 2729709 2729709 6.38 % 17/02/2021
Mitchell Blutt USA 0 2729709 0 2729709 2729709 6.38 % 17/02/2021
Mitchell Blutt USA 0 2729709 0 2729709 2729709 6.38 % 17/02/2021
Consonance Capital Opportunity Fund Management LP Delaware USA 0 268432 0 268432 268432 0.63 % 17/02/2021
Consonance Capital Management LP Delaware USA 0 2461277 0 2461277 2461277 5.75 % 17/02/2021
Consonance Capital Management LP Delaware USA 0 2461277 0 2461277 2461277 5.75 % 17/02/2021
Consonance Capman GP LLC Delaware USA 0 2729709 0 2729709 2729709 6.38 % 17/02/2021
Consonance Capital Opportunity Fund Management LP Delaware USA 0 1193518 0 1193518 1193518 2.04 % 16/02/2021
Mitchell Blutt USA 0 6058505 0 6058505 6058505 9.99 % 16/02/2021
Consonance Capman GP LLC Delaware USA 0 6058505 0 6058505 6058505 9.99 % 16/02/2021
Consonance Capman GP LLC Delaware USA 0 6058505 0 6058505 6058505 9.99 % 16/02/2021
Mitchell Blutt USA 0 6058505 0 6058505 6058505 9.99 % 16/02/2021
Consonance Capital Management LP Delaware USA 0 2461277 0 2461277 2461277 5.75 % 16/02/2021
Consonance Capital Management LP Delaware USA 0 2461277 0 2461277 2461277 5.75 % 16/02/2021
Consonance Capital Opportunity Fund Management LP Delaware USA 0 1193518 0 1193518 1193518 2.04 % 16/02/2021
RTW Master Fund, Ltd. Cayman Islands 0 2567812 0 2567812 2567812 6.1 % 12/02/2021
Roderick Wong United States of America 0 3650069 0 3650069 3650069 8.67 % 12/02/2021
RTW Investments, LP Delaware 0 3650069 0 3650069 3650069 8.67 % 12/02/2021
Phillip Gross United States 0 1150045 0 1150045 1150045 2.69 % 11/02/2021
Adage Capital Advisors, L.L.C. Delaware 0 1150045 0 1150045 1150045 2.69 % 11/02/2021
Adage Capital Partners GP, L.L.C. Delaware 0 1150045 0 1150045 1150045 2.69 % 11/02/2021
Adage Capital Partners, L.P. Delaware 0 1150045 0 1150045 1150045 2.69 % 11/02/2021
Robert Atchinson United States 0 1150045 0 1150045 1150045 2.69 % 11/02/2021
BlackRock, Inc. Delaware 2576897 0 2591711 0 2591711 6.2 % 02/02/2021
Johnson & Johnson Inc. EIN New Jersey 0 2449183 0 2449183 2449183 5.7 % 01/02/2021
Johnson & Johnson EIN New Jersey 0 2449183 0 2449183 2449183 5.7 % 01/02/2021
Adage Capital Advisors, L.L.C. Delaware 0 2200000 0 2200000 2200000 6.39 % 22/05/2020
Robert Atchinson United States 0 2200000 0 2200000 2200000 6.39 % 22/05/2020
Phillip Gross United States 0 2200000 0 2200000 2200000 6.39 % 22/05/2020
Adage Capital Partners, L.P. Delaware 0 2200000 0 2200000 2200000 6.39 % 22/05/2020
Adage Capital Partners GP, L.L.C. Delaware 0 2200000 0 2200000 2200000 6.39 % 22/05/2020
Adage Capital Advisors, L.L.C. Delaware 0 2200000 0 2200000 2200000 6.39 % 22/05/2020
Robert Atchinson United States 0 2200000 0 2200000 2200000 6.39 % 22/05/2020
Phillip Gross United States 0 2200000 0 2200000 2200000 6.39 % 22/05/2020
Adage Capital Partners, L.P. Delaware 0 2200000 0 2200000 2200000 6.39 % 22/05/2020
Adage Capital Partners GP, L.L.C. Delaware 0 2200000 0 2200000 2200000 6.39 % 22/05/2020
Koh, Bong United States 0 113140 0 113140 113140 0.4 % 14/02/2020
Shah, Nimish United States 0 113140 0 113140 113140 0.4 % 14/02/2020
Venrock Healthcare Capital Partners III, L.P. Delaware 0 113140 0 113140 113140 0.4 % 14/02/2020
VHCP Holdings II, LLC Delaware 0 113140 0 113140 113140 0.4 % 14/02/2020
Venrock Healthcare Capital Partners II, L.P. Delaware 0 113140 0 113140 113140 0.4 % 14/02/2020
VHCP Holdings III, LLC Delaware 0 113140 0 113140 113140 0.4 % 14/02/2020
VHCP Management III, LLC Delaware 0 113140 0 113140 113140 0.4 % 14/02/2020
VHCP Management II, LLC Delaware 0 113140 0 113140 113140 0.4 % 14/02/2020
Mark N. Lampert United States 0 2332630 0 2332630 2332630 8.1 % 14/02/2020
BVF II GP LLC Delaware 0 896161 0 896161 896161 3.2 % 14/02/2020
Biotechnology Value Trading Fund OS LP Cayman Islands 0 165691 0 165691 165691 1 % 14/02/2020
BVF Partners OS Ltd. Cayman Islands 0 165691 0 165691 165691 1 % 14/02/2020
BVF GP HOLDINGS LLC Delaware 0 2013354 0 2013354 2013354 7 % 14/02/2020
BVF Partners L.P. Delaware 0 2332630 0 2332630 2332630 8.1 % 14/02/2020
BVF Inc. Delaware 0 2332630 0 2332630 2332630 8.1 % 14/02/2020
Biotechnology Value Fund, L.P. Delaware 0 1117193 0 1117193 1117193 4 % 14/02/2020
BVF I GP LLC Delaware 0 1117193 0 1117193 1117193 4 % 14/02/2020
Biotechnology Value Fund II, L.P. Delaware 0 896161 0 896161 896161 3.2 % 14/02/2020
RTW Master Fund, Ltd. Cayman Islands 0 1792314 0 1792314 1792314 6.59 % 14/02/2020
Roderick Wong United States America 0 2459988 0 2459988 2459988 9.04 % 14/02/2020
RTW Investments, LP Delaware 0 2459988 0 2459988 2459988 9.04 % 14/02/2020
Abigail P. Johnson United States of America 0 0 4080967 0 4080967 14.999 % 07/02/2020
FMR LLC Delaware 564624 0 4080967 0 4080967 14.999 % 07/02/2020
RTW Investments, LP Delaware 0 2186657 0 2186657 2186657 8.04 % 16/12/2019
Roderick Wong United States of America 0 2186657 0 2186657 2186657 8.04 % 16/12/2019
Roderick Wong United States of America 0 2186657 0 2186657 2186657 8.04 % 16/12/2019
RTW Master Fund, Ltd. Cayman Islands 0 1583140 0 1583140 1583140 5.82 % 16/12/2019
RTW Investments, LP Delaware 0 2186657 0 2186657 2186657 8.04 % 16/12/2019
RTW Master Fund, Ltd. Cayman Islands 0 1583140 0 1583140 1583140 5.82 % 16/12/2019
Millennium Management LLC 811066 3.5 % 01/07/2019
Millennium Group Management LLC 811066 3.5 % 01/07/2019
Integrated Core Strategies (US) LLC 811066 3.5 % 01/07/2019
Integrated Core Strategies (US) LLC 811066 3.5 % 01/07/2019
Israel A. Englander 811066 3.5 % 01/07/2019
Millennium Management LLC 811066 3.5 % 01/07/2019
Israel A. Englander 811066 3.5 % 01/07/2019
Millennium Group Management LLC 811066 3.5 % 01/07/2019
VHCP Management II, LLC 1499129 6.4 % 17/06/2019
Venrock Healthcare Capital Partners II, L.P. 1499129 6.4 % 17/06/2019
Venrock Healthcare Capital Partners III, L.P. 1499129 6.4 % 17/06/2019
Shah, Nimish 1499129 6.4 % 17/06/2019
Koh, Bong 1499129 6.4 % 17/06/2019
VHCP Holdings II, LLC 1499129 6.4 % 17/06/2019
VHCP Holdings III, LLC 1499129 6.4 % 17/06/2019
VHCP Management III, LLC 1499129 6.4 % 17/06/2019
Dr. Jeffrey R. Jay, M.D. USA 0 955618 0 955618 955618 3.95 % 14/02/2019
Mr. David Kroin USA 0 955618 0 955618 955618 3.95 % 14/02/2019
Mr. David Kroin USA 0 955618 0 955618 955618 3.95 % 14/02/2019
Great Point Partners, LLC USA 0 955618 0 955618 955618 3.95 % 14/02/2019
Dr. Jeffrey R. Jay, M.D. USA 0 955618 0 955618 955618 3.95 % 14/02/2019
Great Point Partners, LLC USA 0 955618 0 955618 955618 3.95 % 14/02/2019
BVF Inc. Delaware 0 2502390 0 2502390 2502390 9.99 % 14/02/2019
Mark N. Lampert United States 0 2502390 0 2502390 2502390 9.99 % 14/02/2019
BVF Partners OS Ltd. Cayman Islands 0 153328 0 153328 153328 0 % 14/02/2019
Biotechnology Value Trading Fund OS LP Cayman Islands 0 153328 0 153328 153328 0 % 14/02/2019
Biotechnology Value Fund II, L.P. Delaware 0 785039 0 785039 785039 3.2 % 14/02/2019
Biotechnology Value Fund, L.P. Delaware 0 1247629 0 1247629 1247629 5.1 % 14/02/2019
BVF Partners OS Ltd. Cayman Islands 0 153328 0 153328 153328 0 % 14/02/2019
Biotechnology Value Fund, L.P. Delaware 0 1247629 0 1247629 1247629 5.1 % 14/02/2019
BVF Partners L.P. Delaware 0 2502390 0 2502390 2502390 9.99 % 14/02/2019
Biotechnology Value Fund II, L.P. Delaware 0 785039 0 785039 785039 3.2 % 14/02/2019
Biotechnology Value Trading Fund OS LP Cayman Islands 0 153328 0 153328 153328 0 % 14/02/2019
BVF Partners L.P. Delaware 0 2502390 0 2502390 2502390 9.99 % 14/02/2019
BVF Inc. Delaware 0 2502390 0 2502390 2502390 9.99 % 14/02/2019
Mark N. Lampert United States 0 2502390 0 2502390 2502390 9.99 % 14/02/2019
Mark C. Wehrly United States 0 2199674 0 21996741 2199674 9.9 % 13/02/2019
Andrew J. M. Spokes United Kingdom 0 2199674 0 2199674 2199674 9.9 % 13/02/2019
William Seybold United States 0 2199674 0 2199674 2199674 9.9 % 13/02/2019
Thomas G. Roberts, Jr. United States 0 2199674 0 2199674 2199674 9.9 % 13/02/2019
Rajiv A. Patel United States 0 2199674 0 2199674 2199674 9.9 % 13/02/2019
Michael G. Linn United States 0 2199674 0 2199674 2199674 9.9 % 13/02/2019
Monica R. Landry United States 0 2199674 0 2199674 2199674 9.9 % 13/02/2019
David T. Kim United States 0 2199674 0 2199674 2199674 9.9 % 13/02/2019
Richard B. Fried United States 0 2199674 0 2199674 2199674 9.9 % 13/02/2019
Michael B. Fisch United States 0 2199674 0 2199674 2199674 9.9 % 13/02/2019
Philip D. Dreyfuss United States 0 2199674 0 2199674 2199674 9.9 % 13/02/2019
Farallon F5 , L.L.C. Delaware 0 59113 0 59113 59113 0.2 % 13/02/2019
Farallon Institutional V, L.L.C. Delaware 0 72716 0 72716 72716 0.3 % 13/02/2019
Farallon Partners, L.L.C. Delaware 0 2381100 0 2381100 2381100 9.8 % 13/02/2019
Farallon Capital Investors, L.P. Delaware 0 30005 0 30005 30005 0.1 % 13/02/2019
Farallon Capital Offshore Investors II, L.P. Cayman Islands 0 1164834 0 1164834 1164834 4.8 % 13/02/2019
Four Crossings Institutional Partners V, L.P. Delaware 0 72716 0 72716 72716 0.3 % 13/02/2019
Farallon Capital Institutional Partners III, L.P. Delaware 0 59220 0 59220 59220 0.2 % 13/02/2019
Farallon Capital Institutional Partners II, L.P. California 0 84919 0 84919 84919 0.4 % 13/02/2019
Farallon Capital Institutional Partners, L.P. California 0 498705 0 498705 498705 2.1 % 13/02/2019
Farallon Capital Partners, L.P. California 0 470700 0 470700 470700 1.9 % 13/02/2019
Farallon Capital F5 Master I, L.P. Delaware 0 59113 0 59113 59113 0.2 % 13/02/2019
John R. Warren United States 0 2199674 0 2199674 2199674 9.9 % 13/02/2019
Adage Capital Advisors, L.L.C. Delaware 0 0 0 0 0 0 % 13/02/2019
Phillip Gross United States 0 0 0 0 0 0 % 13/02/2019
Robert Atchinson United States 0 0 0 0 0 0 % 13/02/2019
Adage Capital Partners, L.P. Delaware 0 0 0 0 0 0 % 13/02/2019
Adage Capital Partners GP, L.L.C. Delaware 0 0 0 0 0 0 % 13/02/2019
FMR LLC Delaware 556924 0 3627902 0 3627902 14.999 % 13/02/2019
FMR LLC Delaware 556924 0 3627902 0 3627902 14.999 % 13/02/2019
Abigail P. Johnson United States of America 0 0 3627902 0 3627902 14.999 % 13/02/2019
Abigail P. Johnson United States of America 0 0 3627902 0 3627902 14.999 % 13/02/2019
OR United States 0 0 0 0 0 0 % 05/02/2019
OR United States 0 0 0 0 0 0 % 05/02/2019
Canaan Partners X LLC Delaware 1077832 0 1077832 0 1077832 4.5 % 24/01/2019
Canaan X L.P. Cayman Islands 1077832 0 1077832 0 1077832 4.5 % 24/01/2019
Canaan X L.P. Cayman Islands 1077832 0 1077832 0 1077832 4.5 % 24/01/2019
Canaan Partners X LLC Delaware 1077832 0 1077832 0 1077832 4.5 % 24/01/2019
Perceptive Advisors LLC Delaware 0 1291355 0 1291355 1291355 5.3 % 10/12/2018
Joseph Edelman United States of America 0 1291355 0 1291355 1291355 5.3 % 10/12/2018
Perceptive Life Sciences Master Fund, Ltd. Cayman Islands 0 1291355 0 1291355 1291355 5.3 % 10/12/2018
Farallon Capital Institutional Partners, L.P. California 0 494647 0 494647 494647 2.1 % 17/08/2018
Andrew J. M. Spokes United Kingdom 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
John R. Warren United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Mark C. Wehrly United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Farallon Partners, L.L.C. Delaware 0 2348135 0 2348135 2348135 9.8 % 17/08/2018
Farallon Capital F5 Master I, L.P. Delaware 0 58003 0 58003 58003 0.2 % 17/08/2018
Farallon Capital Delaware 0 30461 0 30461 30461 0.1 % 17/08/2018
Farallon Partners, L.L.C. Delaware 0 2348135 0 2348135 2348135 9.8 % 17/08/2018
Farallon Institutional Delaware 0 71584 0 71584 71584 0.3 % 17/08/2018
Farallon Capital Offshore Investors II, L.P. Cayman Islands 0 1141259 0 1141259 1141259 4.8 % 17/08/2018
Four Crossings Institutional Partners V, L.P. Delaware 0 71584 0 71584 71584 0.3 % 17/08/2018
Farallon Capital Institutional Partners III, L.P. Delaware 0 59217 0 59217 59217 0.3 % 17/08/2018
Farallon F5 Delaware 0 57887 0 57887 57887 0.2 % 17/08/2018
Farallon Capital Institutional Partners II, L.P. California 0 83565 0 83565 83565 0.3 % 17/08/2018
William Seybold United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Farallon Capital Partners, L.P. California 0 467286 0 467286 467286 1.9 % 17/08/2018
Philip D. Dreyfuss United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Michael B. Fisch United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Richard B. Fried United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
David T. Kim United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Monica R. Landry United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Michael G. Linn United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Rajiv A. Patel United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Thomas G. Roberts, Jr. United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Farallon Capital Institutional Partners II, L.P. California 0 83565 0 83565 83565 0.3 % 17/08/2018
Farallon Capital Institutional Partners III, L.P. Delaware 0 59217 0 59217 59217 0.3 % 17/08/2018
Four Crossings Institutional Partners V, L.P. Delaware 0 71584 0 71584 71584 0.3 % 17/08/2018
Farallon Capital Offshore Investors II, L.P. Cayman Islands 0 1141259 0 1141259 1141259 4.8 % 17/08/2018
Farallon Capital Delaware 0 30461 0 30461 30461 0.1 % 17/08/2018
Farallon Capital F5 Master I, L.P. Delaware 0 58003 0 58003 58003 0.2 % 17/08/2018
Farallon Capital Partners, L.P. California 0 467286 0 467286 467286 1.9 % 17/08/2018
Farallon Capital Institutional Partners, L.P. California 0 494647 0 494647 494647 2.1 % 17/08/2018
Mark C. Wehrly United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
John R. Warren United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Andrew J. M. Spokes United Kingdom 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
William Seybold United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Thomas G. Roberts, Jr. United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Rajiv A. Patel United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Michael G. Linn United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Monica R. Landry United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
David T. Kim United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Richard B. Fried United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Michael B. Fisch United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Philip D. Dreyfuss United States 0 2406022 0 2406022 2406022 9.9 % 17/08/2018
Farallon F5 Delaware 0 57887 0 57887 57887 0.2 % 17/08/2018
Farallon Institutional Delaware 0 71584 0 71584 71584 0.3 % 17/08/2018
Mark N. Lampert United States 0 2617967 0 2617967 2617967 10.9 % 10/08/2018
Biotechnology Value Fund II, L.P. Delaware 0 951770 0 951770 951770 4 % 10/08/2018
Biotechnology Value Trading Fund OS LP Cayman Islands 0 199196 0 199196 199196 0 % 10/08/2018
BVF Partners OS Ltd. Cayman Islands 0 199196 0 199196 199196 0 % 10/08/2018
BVF Partners L.P. Delaware 0 2617967 0 2617967 2617967 10.9 % 10/08/2018
BVF Inc. Delaware 0 2617967 0 2617967 2617967 10.9 % 10/08/2018
Mark N. Lampert United States 0 2617967 0 2617967 2617967 10.9 % 10/08/2018
BVF Inc. Delaware 0 2617967 0 2617967 2617967 10.9 % 10/08/2018
BVF Partners L.P. Delaware 0 2617967 0 2617967 2617967 10.9 % 10/08/2018
BVF Partners OS Ltd. Cayman Islands 0 199196 0 199196 199196 0 % 10/08/2018
Biotechnology Value Trading Fund OS LP Cayman Islands 0 199196 0 199196 199196 0 % 10/08/2018
Biotechnology Value Fund II, L.P. Delaware 0 951770 0 951770 951770 4 % 10/08/2018
Biotechnology Value Fund, L.P. Delaware 0 1209268 0 1209268 1209268 5 % 10/08/2018
Biotechnology Value Fund, L.P. Delaware 0 1209268 0 1209268 1209268 5 % 10/08/2018
Mr. David Kroin USA 0 1473609 0 1473609 1473609 6.95 % 02/07/2018
Dr. Jeffrey R. Jay, M.D. USA 0 1473609 0 1473609 1473609 6.95 % 02/07/2018
Great Point Partners, LLC USA 0 1473609 0 1473609 1473609 6.95 % 02/07/2018
Mr. David Kroin USA 0 1473609 0 1473609 1473609 6.95 % 02/07/2018
Dr. Jeffrey R. Jay, M.D. USA 0 1473609 0 1473609 1473609 6.95 % 02/07/2018
Great Point Partners, LLC USA 0 1473609 0 1473609 1473609 6.95 % 02/07/2018
Mark N. Lampert United States 0 1467967 0 1467967 1467967 6.9 % 24/05/2018
Mark N. Lampert United States 0 1467967 0 1467967 1467967 6.9 % 24/05/2018
BVF Inc. Delaware 0 1467967 0 1467967 1467967 6.9 % 24/05/2018
BVF Partners L.P. Delaware 0 1467967 0 1467967 1467967 6.9 % 24/05/2018
BVF Partners OS Ltd. Cayman Islands 0 121206 0 121206 121206 0 % 24/05/2018
Biotechnology Value Trading Fund OS LP Cayman Islands 0 121206 0 121206 121206 0 % 24/05/2018
Biotechnology Value Fund II, L.P. Delaware 0 478357 0 478357 478357 2.3 % 24/05/2018
Biotechnology Value Fund, L.P. Delaware 0 710681 0 710681 710681 3.4 % 24/05/2018
BVF Partners L.P. Delaware 0 1467967 0 1467967 1467967 6.9 % 24/05/2018
BVF Partners OS Ltd. Cayman Islands 0 121206 0 121206 121206 0 % 24/05/2018
BVF Inc. Delaware 0 1467967 0 1467967 1467967 6.9 % 24/05/2018
Biotechnology Value Trading Fund OS LP Cayman Islands 0 121206 0 121206 121206 0 % 24/05/2018
Biotechnology Value Fund II, L.P. Delaware 0 478357 0 478357 478357 2.3 % 24/05/2018
Biotechnology Value Fund, L.P. Delaware 0 710681 0 710681 710681 3.4 % 24/05/2018
Pharmstandard International S.A. Luxembourg 0 982270 0 982270 982270 4.8 % 20/02/2018
Pharmstandard International S.A. Luxembourg 0 982270 0 982270 982270 4.8 % 20/02/2018
Joint Stock Company “Pharmstandard” Russian Federation 0 982270 0 982270 982270 4.8 % 20/02/2018
Joint Stock Company “Pharmstandard” Russian Federation 0 982270 0 982270 982270 4.8 % 20/02/2018
OR Aisling Capital IV, LP Delaware 1015761 0 1015761 0 1015761 5 % 07/02/2018
OR Aisling Capital Partners IV, LP Delaware 1015761 0 1015761 0 1015761 5 % 07/02/2018
OR Aisling Capital Partners IV LLC Delaware 1015761 0 1015761 0 1015761 5 % 07/02/2018
OR Steve Elms United States 0 1015761 0 1015761 1015761 5 % 07/02/2018
OR Andrew Schiff United States 0 1015761 0 1015761 1015761 5 % 07/02/2018
OR United States 0 1015761 0 1015761 1015761 5 % 07/02/2018
Adage Capital Partners, L.P. Delaware 0 2056076 0 2056076 2056076 9.7 % 04/01/2018
Robert Atchinson United States 0 2056076 0 2056076 2056076 9.7 % 04/01/2018
Adage Capital Advisors, L.L.C. Delaware 0 2056076 0 2056076 2056076 9.7 % 04/01/2018
Adage Capital Partners GP, L.L.C. Delaware 0 2056076 0 2056076 2056076 9.7 % 04/01/2018
Adage Capital Partners, L.P. Delaware 0 2056076 0 2056076 2056076 9.7 % 04/01/2018
Phillip Gross United States 0 2056076 0 2056076 2056076 9.7 % 04/01/2018
Robert Atchinson United States 0 2056076 0 2056076 2056076 9.7 % 04/01/2018
Adage Capital Advisors, L.L.C. Delaware 0 2056076 0 2056076 2056076 9.7 % 04/01/2018
Phillip Gross United States 0 2056076 0 2056076 2056076 9.7 % 04/01/2018
Adage Capital Partners GP, L.L.C. Delaware 0 2056076 0 2056076 2056076 9.7 % 04/01/2018
Robert Atchinson United States 0 2056076 0 2056076 2056076 12.2 % 01/06/2017
Adage Capital Partners GP, L.L.C. Delaware 0 2056076 0 2056076 2056076 12.2 % 01/06/2017
Adage Capital Partners, L.P. Delaware 0 2056076 0 2056076 2056076 12.2 % 01/06/2017
Adage Capital Partners, L.P. Delaware 0 2056076 0 2056076 2056076 12.2 % 01/06/2017
Adage Capital Partners GP, L.L.C. Delaware 0 2056076 0 2056076 2056076 12.2 % 01/06/2017
Adage Capital Advisors, L.L.C. Delaware 0 2056076 0 2056076 2056076 12.2 % 01/06/2017
Robert Atchinson United States 0 2056076 0 2056076 2056076 12.2 % 01/06/2017
Phillip Gross United States 0 2056076 0 2056076 2056076 12.2 % 01/06/2017
Phillip Gross United States 0 2056076 0 2056076 2056076 12.2 % 01/06/2017
Adage Capital Advisors, L.L.C. Delaware 0 2056076 0 2056076 2056076 12.2 % 01/06/2017
Peter Kolchinsky United States 0 692563 0 692563 692563 4.1 % 14/02/2017
RA Capital Management, LLC Massachusetts 0 692563 0 692563 692563 4.1 % 14/02/2017
RA Capital Healthcare Fund, L.P. Delaware 0 569980 0 569980 569980 3.4 % 14/02/2017
S Public Joint Stock Company “Pharmstandard” Russian Federation 0 983570 0 983570 983570 5.884 % 13/02/2017
S Pharmstandard International S.A. Luxembourg 0 983570 0 983570 983570 5.88 % 13/02/2017
Adage Capital Advisors, L.L.C. Delaware 0 1531076 0 1531076 1531076 9.16 % 09/02/2017
Adage Capital Partners, L.P. Delaware 0 1531076 0 1531076 1531076 9.16 % 09/02/2017
Phillip Gross United States 0 1531076 0 1531076 1531076 9.16 % 09/02/2017
Robert Atchinson United States 0 1531076 0 1531076 1531076 9.16 % 09/02/2017
Adage Capital Partners GP, L.L.C. Delaware 0 1531076 0 1531076 1531076 9.16 % 09/02/2017
Canaan Partners X LLC Delaware 2453255 0 2453255 0 2453255 14.7 % 26/01/2017
Canaan Partners X LLC Delaware 2453255 0 2453255 0 2453255 14.7 % 26/01/2017
Canaan X L.P. Cayman Islands 2453255 0 2453255 0 2453255 14.7 % 26/01/2017
Canaan X L.P. Cayman Islands 2453255 0 2453255 0 2453255 14.7 % 26/01/2017
Fidelity Series Small Cap Opportunities Fund Massachusetts 1069600 0 0 0 1069600 6.497 % 11/10/2016
FMR LLC Delaware 8400 0 2128719 0 2128719 12.931 % 11/10/2016
FMR LLC Delaware 8400 0 2128719 0 2128719 12.931 % 11/10/2016
Abigail P. Johnson United States of America 0 0 2128719 0 2128719 12.931 % 11/10/2016
Abigail P. Johnson United States of America 0 0 2128719 0 2128719 12.931 % 11/10/2016
Fidelity Series Small Cap Opportunities Fund Massachusetts 1069600 0 0 0 1069600 6.497 % 11/10/2016
OR United States 0 833333 0 833333 833333 5.1 % 12/09/2016
OR United States 0 833333 0 833333 833333 5.1 % 12/09/2016
RA Capital Management, LLC Massachusetts 0 1109229 0 1109229 1109229 6.8 % 25/08/2016
RA Capital Healthcare Fund, L.P. Delaware 0 909203 0 909203 909203 5.6 % 25/08/2016
RA Capital Healthcare Fund, L.P. Delaware 0 909203 0 909203 909203 5.6 % 25/08/2016
Peter Kolchinsky United States 0 1109229 0 1109229 1109229 6.8 % 25/08/2016
RA Capital Management, LLC Massachusetts 0 1109229 0 1109229 1109229 6.8 % 25/08/2016
Peter Kolchinsky United States 0 1109229 0 1109229 1109229 6.8 % 25/08/2016
Adage Capital Partners GP, L.L.C. Delaware 0 1581076 0 1581076 1581076 9.69 % 19/08/2016
Robert Atchinson United States 0 1581076 0 1581076 1581076 9.69 % 19/08/2016
Adage Capital Partners, L.P. Delaware 0 1581076 0 1581076 1581076 9.69 % 19/08/2016
Phillip Gross United States 0 1581076 0 1581076 1581076 9.69 % 19/08/2016
Phillip Gross United States 0 1581076 0 1581076 1581076 9.69 % 19/08/2016
Adage Capital Partners, L.P. Delaware 0 1581076 0 1581076 1581076 9.69 % 19/08/2016
Robert Atchinson United States 0 1581076 0 1581076 1581076 9.69 % 19/08/2016
Adage Capital Advisors, L.L.C. Delaware 0 1581076 0 1581076 1581076 9.69 % 19/08/2016
Adage Capital Partners GP, L.L.C. Delaware 0 1581076 0 1581076 1581076 9.69 % 19/08/2016
Adage Capital Advisors, L.L.C. Delaware 0 1581076 0 1581076 1581076 9.69 % 19/08/2016
Johnson & Johnson EIN New Jersey 0 2449183 0 2449183 2449183 15 % 19/08/2016
Johnson & Johnson Inc. EIN New Jersey 0 2449183 0 2449183 2449183 15 % 19/08/2016

Senat trading

Bureau Date de la transaction Date de réception Type Amount Commentaire

Senat Divulgation

Représentant Date de la transaction Date de divulgation Type Amount District