Roderick Wong, M.D. |
United States |
0 |
1968002 |
0 |
1968002 |
1968002 |
2.1 % |
14/11/2024 |
RTW Investments, LP |
Delaware |
0 |
1968002 |
0 |
1968002 |
1968002 |
2.1 % |
14/11/2024 |
Frank M. Sands |
United States |
0 |
2955657 |
0 |
4118008 |
4118008 |
5 % |
13/02/2024 |
Sands Capital Management, LLC |
Delaware |
0 |
2955657 |
0 |
4118008 |
4118008 |
5 % |
13/02/2024 |
Wellington Group Holdings LLP |
Delaware |
0 |
4100801 |
0 |
4415029 |
4415029 |
5.38 % |
08/02/2024 |
Wellington Management Company LLP |
Delaware |
0 |
4084307 |
0 |
4331419 |
4331419 |
5.27 % |
08/02/2024 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4100801 |
0 |
4415029 |
4415029 |
5.38 % |
08/02/2024 |
Wellington Management Group LLP |
Massachusetts |
0 |
4100801 |
0 |
4415029 |
4415029 |
5.38 % |
08/02/2024 |
BlackRock, Inc. |
Delaware |
4967673 |
0 |
5238400 |
0 |
5238400 |
6.4 % |
29/01/2024 |
The Vanguard Group |
Pennsylvania |
0 |
28390 |
7132029 |
104494 |
7236523 |
10.12 % |
11/09/2023 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
766521 |
0 |
4096388 |
0 |
4096388 |
5.8 % |
14/02/2023 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
766521 |
0 |
4096388 |
0 |
4096388 |
5.8 % |
14/02/2023 |
BlackRock, Inc. |
Delaware |
4097323 |
0 |
4336492 |
0 |
4336492 |
6.2 % |
03/02/2023 |
J. Christopher Donahue |
Pennsylvania |
|
3094500 |
|
3094500 |
3094500 |
4.41 % |
10/01/2023 |
Thomas R. Donahue |
Pennsylvania |
|
3094500 |
|
3094500 |
3094500 |
4.41 % |
10/01/2023 |
Voting Shares Irrevocable Trust |
Pennsylvania |
3094500 |
|
3094500 |
|
3094500 |
4.41 % |
10/01/2023 |
Federated Hermes, Inc. |
Pennsylvania |
3094500 |
|
3094500 |
|
3094500 |
4.41 % |
10/01/2023 |
Capital International Investors |
Delaware |
1707799 |
0 |
1711517 |
0 |
1711517 |
2.4 % |
09/12/2022 |
Capital International Investors |
Delaware |
1707799 |
0 |
1711517 |
0 |
1711517 |
2.4 % |
09/12/2022 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
1837406 |
0 |
5675998 |
0 |
5675998 |
8.1 % |
10/08/2022 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
1837406 |
0 |
5675998 |
0 |
5675998 |
8.1 % |
10/08/2022 |
BlackRock, Inc. |
Delaware |
3239392 |
0 |
3411414 |
0 |
3411414 |
4.9 % |
09/03/2022 |
Voting Shares Irrevocable Trust |
|
3986870 |
|
3986870 |
|
3986870 |
5.85 % |
14/02/2022 |
(entities only Federated Hermes, Inc. |
|
3986870 |
|
3986870 |
|
3986870 |
5.85 % |
14/02/2022 |
Rhodora J. Donahue |
|
|
3986870 |
|
3986870 |
3986870 |
5.85 % |
14/02/2022 |
Thomas R. Donahue |
|
|
3986870 |
|
3986870 |
3986870 |
5.85 % |
14/02/2022 |
J. Christopher Donahue |
|
|
3986870 |
|
3986870 |
3986870 |
5.85 % |
14/02/2022 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
3600803 |
0 |
11525089 |
0 |
11525089 |
16.9 % |
14/02/2022 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
3600803 |
0 |
11525089 |
0 |
11525089 |
16.9 % |
14/02/2022 |
Capital International Investors |
Delaware |
5579689 |
0 |
5629453 |
0 |
5629453 |
8.3 % |
11/02/2022 |
Capital International Investors |
Delaware |
5579689 |
0 |
5629453 |
0 |
5629453 |
8.3 % |
11/02/2022 |
The Vanguard Group |
Pennsylvania For |
0 |
37387 |
5825268 |
95300 |
5920568 |
8.69 % |
10/02/2022 |
BlackRock, Inc. |
Delaware |
3287113 |
0 |
3484652 |
0 |
3484652 |
5.1 % |
03/02/2022 |
Capital Research Global Investors |
Delaware |
3361792 |
0 |
3361792 |
0 |
3361792 |
5 % |
08/10/2021 |
Capital Research Global Investors |
Delaware |
3361792 |
0 |
3361792 |
0 |
3361792 |
5 % |
08/10/2021 |
Capital International Investors |
Delaware |
6605639 |
0 |
6899493 |
0 |
6899493 |
10.5 % |
16/02/2021 |
Capital International Investors |
Delaware |
6605639 |
0 |
6899493 |
0 |
6899493 |
10.5 % |
16/02/2021 |
Capital World Investors |
Delaware |
3129724 |
0 |
3129724 |
0 |
3129724 |
4.7 % |
16/02/2021 |
Capital Research Global Investors |
Delaware |
7261901 |
0 |
7261901 |
0 |
7261901 |
11 % |
16/02/2021 |
Capital Research Global Investors |
Delaware |
7261901 |
0 |
7261901 |
0 |
7261901 |
11 % |
16/02/2021 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
2683769 |
0 |
9470492 |
0 |
9470492 |
14.3 % |
16/02/2021 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
2683769 |
0 |
9470492 |
0 |
9470492 |
14.3 % |
16/02/2021 |
Thomas R. Donahue |
|
|
4280528 |
|
4280528 |
4280528 |
6.47 % |
12/02/2021 |
Rhodora J. Donahue |
|
|
4280528 |
|
4280528 |
4280528 |
6.47 % |
12/02/2021 |
J. Christopher Donahue |
|
|
4280528 |
|
4280528 |
4280528 |
6.47 % |
12/02/2021 |
(entities only Federated Hermes, Inc. |
|
4280528 |
|
4280528 |
|
4280528 |
6.47 % |
12/02/2021 |
Voting Shares Irrevocable Trust |
|
4280528 |
|
4280528 |
|
4280528 |
6.47 % |
12/02/2021 |
The Vanguard Group |
Pennsylvania For |
0 |
143207 |
5458053 |
192332 |
5650385 |
8.57 % |
10/02/2021 |
BlackRock, Inc. |
Delaware |
5162616 |
0 |
5287476 |
0 |
5287476 |
8 % |
01/02/2021 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
1554558 |
0 |
6618920 |
0 |
6618920 |
11.1 % |
11/05/2020 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
1554558 |
0 |
6618920 |
0 |
6618920 |
11.1 % |
11/05/2020 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
926616 |
0 |
4491769 |
0 |
4491769 |
7.7 % |
14/02/2020 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
926616 |
0 |
4491769 |
0 |
4491769 |
7.7 % |
14/02/2020 |
The Vanguard Group |
Pennsylvania |
115218 |
8812 |
4736484 |
116675 |
4853159 |
8.4 % |
12/02/2020 |
FMR LLC |
Delaware |
171655 |
0 |
1824565 |
0 |
1824565 |
3.158 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
1824565 |
0 |
1824565 |
3.158 % |
07/02/2020 |
FMR LLC |
Delaware |
171655 |
0 |
1824565 |
0 |
1824565 |
3.158 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
1824565 |
0 |
1824565 |
3.158 % |
07/02/2020 |
BlackRock, Inc. |
Delaware |
4568813 |
0 |
4733084 |
0 |
4733084 |
8.2 % |
06/02/2020 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
1187208 |
0 |
1284110 |
1284110 |
2.22 % |
08/01/2020 |
Wellington Management Group LLP |
Massachusetts |
0 |
1187208 |
0 |
1284110 |
1284110 |
2.22 % |
08/01/2020 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
1187208 |
0 |
1284110 |
1284110 |
2.22 % |
08/01/2020 |
Wellington Group Holdings LLP |
Delaware |
0 |
1187208 |
0 |
1284110 |
1284110 |
2.22 % |
08/01/2020 |
Wellington Management Group LLP |
Massachusetts |
0 |
1187208 |
0 |
1284110 |
1284110 |
2.22 % |
08/01/2020 |
Wellington Group Holdings LLP |
Delaware |
0 |
1187208 |
0 |
1284110 |
1284110 |
2.22 % |
08/01/2020 |
Wellington Management Group LLP |
Massachusetts |
0 |
2424422 |
0 |
3259962 |
3259962 |
5.65 % |
10/10/2019 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2424422 |
0 |
3259962 |
3259962 |
5.65 % |
10/10/2019 |
Wellington Management Group LLP |
Massachusetts |
0 |
2424422 |
0 |
3259962 |
3259962 |
5.65 % |
10/10/2019 |
Wellington Group Holdings LLP |
Delaware |
0 |
2424422 |
0 |
3259962 |
3259962 |
5.65 % |
10/10/2019 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2424422 |
0 |
3259962 |
3259962 |
5.65 % |
10/10/2019 |
Wellington Group Holdings LLP |
Delaware |
0 |
2424422 |
0 |
3259962 |
3259962 |
5.65 % |
10/10/2019 |
New Perspective Fund |
Maryland |
0 |
0 |
0 |
0 |
2768288 |
5.4 % |
15/02/2019 |
New Perspective Fund |
Maryland |
0 |
0 |
0 |
0 |
2768288 |
5.4 % |
15/02/2019 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
469409 |
0 |
2730381 |
0 |
2730381 |
5.3 % |
14/02/2019 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4620643 |
0 |
5996082 |
5996082 |
11.85 % |
12/02/2019 |
Wellington Management Company LLP |
Delaware |
0 |
4494052 |
0 |
5514231 |
5514231 |
10.9 % |
12/02/2019 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4620643 |
0 |
5996082 |
5996082 |
11.85 % |
12/02/2019 |
Wellington Management Group LLP |
Massachusetts |
0 |
4620643 |
0 |
5996082 |
5996082 |
11.85 % |
12/02/2019 |
Wellington Group Holdings LLP |
Delaware |
0 |
4620643 |
0 |
5996082 |
5996082 |
11.85 % |
12/02/2019 |
Wellington Management Group LLP |
Massachusetts |
0 |
4620643 |
0 |
5996082 |
5996082 |
11.85 % |
12/02/2019 |
Wellington Group Holdings LLP |
Delaware |
0 |
4620643 |
0 |
5996082 |
5996082 |
11.85 % |
12/02/2019 |
Wellington Management Company LLP |
Delaware |
0 |
4494052 |
0 |
5514231 |
5514231 |
10.9 % |
12/02/2019 |
The Vanguard Group |
Pennsylvania |
98900 |
6710 |
4060790 |
100990 |
4161780 |
8.22 % |
11/02/2019 |
New Perspective Fund |
Delaware |
0 |
0 |
0 |
0 |
2768288 |
6.5 % |
13/02/2018 |
New Perspective Fund |
Delaware |
0 |
0 |
0 |
0 |
2768288 |
6.5 % |
13/02/2018 |
The Vanguard Group |
Pennsylvania |
77102 |
3850 |
3088533 |
77932 |
3166465 |
7.43 % |
09/02/2018 |
Wellington Group Holdings LLP |
Delaware |
0 |
4505983 |
0 |
5859120 |
5859120 |
13.76 % |
08/02/2018 |
Wellington Management Company LLP |
Delaware |
0 |
4344935 |
0 |
5334743 |
5334743 |
12.53 % |
08/02/2018 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4505983 |
0 |
5859120 |
5859120 |
13.76 % |
08/02/2018 |
Wellington Management Group LLP |
Massachusetts |
0 |
4505983 |
0 |
5859120 |
5859120 |
13.76 % |
08/02/2018 |
BlackRock, Inc. |
Delaware |
3650795 |
0 |
3731887 |
0 |
3731887 |
8.8 % |
23/01/2018 |
Capital International Investors |
California |
4139700 |
0 |
4411165 |
0 |
4411165 |
10.3 % |
10/01/2018 |
Capital International Investors |
California |
4139700 |
0 |
4411165 |
0 |
4411165 |
10.3 % |
10/01/2018 |
Abigail P. Johnson |
United States of America |
0 |
0 |
3806612 |
0 |
3806612 |
8.996 % |
10/07/2017 |
FMR LLC |
Delaware |
435907 |
0 |
3806612 |
0 |
3806612 |
8.996 % |
10/07/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
3806612 |
0 |
3806612 |
8.996 % |
10/07/2017 |
FMR LLC |
Delaware |
435907 |
0 |
3806612 |
0 |
3806612 |
8.996 % |
10/07/2017 |
The Vanguard Group |
Pennsylvania |
72233 |
3850 |
2759153 |
74163 |
2833316 |
6.93 % |
13/02/2017 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3928083 |
0 |
5255191 |
5255191 |
12.86 % |
09/02/2017 |
Wellington Group Holdings LLP |
Delaware |
0 |
3928083 |
0 |
5255191 |
5255191 |
12.86 % |
09/02/2017 |
Wellington Management Group LLP |
Massachusetts |
0 |
3928083 |
0 |
5255191 |
5255191 |
12.86 % |
09/02/2017 |
Wellington Management Company LLP |
Delaware |
0 |
3755459 |
0 |
4907029 |
4907029 |
12.01 % |
09/02/2017 |
BlackRock, Inc. |
Delaware |
2866770 |
0 |
2942718 |
0 |
2942718 |
7.2 % |
26/01/2017 |
Wellington Management Company LLP |
Delaware |
0 |
2840421 |
0 |
3759725 |
3759725 |
9.65 % |
10/03/2016 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2989614 |
0 |
4050477 |
4050477 |
10.39 % |
10/03/2016 |
Wellington Group Holdings LLP |
Delaware |
0 |
2989614 |
0 |
4050477 |
4050477 |
10.39 % |
10/03/2016 |
Wellington Management Group LLP |
Massachusetts |
0 |
2989614 |
0 |
4050477 |
4050477 |
10.39 % |
10/03/2016 |
Wellington Management Company LLP |
Delaware |
0 |
2840421 |
0 |
3759725 |
3759725 |
9.65 % |
10/03/2016 |
Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2989614 |
0 |
4050477 |
4050477 |
10.39 % |
10/03/2016 |
Wellington Group Holdings LLP |
Delaware |
0 |
2989614 |
0 |
4050477 |
4050477 |
10.39 % |
10/03/2016 |
Wellington Management Group LLP |
Massachusetts |
0 |
2989614 |
0 |
4050477 |
4050477 |
10.39 % |
10/03/2016 |
SMALLCAP World Fund, Inc. |
Maryland |
0 |
0 |
0 |
0 |
905807 |
2.3 % |
12/02/2016 |
Select Biotechnology Portfolio |
Massachusetts |
1976978 |
0 |
0 |
0 |
1976978 |
5.09 % |
12/02/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
5825205 |
0 |
5825205 |
14.999 % |
12/02/2016 |
Select Biotechnology Portfolio |
Massachusetts |
1976978 |
0 |
0 |
0 |
1976978 |
5.09 % |
12/02/2016 |
FMR LLC |
Delaware |
281247 |
0 |
5825205 |
0 |
5825205 |
14.999 % |
12/02/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
5825205 |
0 |
5825205 |
14.999 % |
12/02/2016 |
FMR LLC |
Delaware |
281247 |
0 |
5825205 |
0 |
5825205 |
14.999 % |
12/02/2016 |
The Vanguard Group |
Pennsylvania |
82307 |
1500 |
2311380 |
82207 |
2393587 |
6.16 % |
11/02/2016 |
BlackRock, Inc. |
Delaware |
3219531 |
0 |
3294747 |
0 |
3294747 |
8.5 % |
28/01/2016 |
BlackRock, Inc. |
Delaware |
1662517 |
0 |
1690600 |
0 |
1690600 |
4.8 % |
10/03/2015 |
TPG Group Holdings |
Delaware |
0 |
1596420 |
0 |
1596420 |
1596420 |
4.6 % |
13/02/2015 |
James G. Coulter |
United States |
0 |
1596420 |
0 |
1596420 |
1596420 |
4.6 % |
13/02/2015 |
David Bonderman |
United States |
0 |
1596420 |
0 |
1596420 |
1596420 |
4.6 % |
13/02/2015 |
TPG Group Holdings |
Delaware |
0 |
1596420 |
0 |
1596420 |
1596420 |
4.6 % |
13/02/2015 |
James G. Coulter |
United States |
0 |
1596420 |
0 |
1596420 |
1596420 |
4.6 % |
13/02/2015 |
David Bonderman |
United States |
0 |
1596420 |
0 |
1596420 |
1596420 |
4.6 % |
13/02/2015 |
Pandanus Associates, Inc. |
Delaware |
0 |
0 |
517014 |
0 |
517014 |
1.62 % |
13/02/2015 |
Pandanus Partners, L.P. |
Delaware |
0 |
0 |
517014 |
0 |
517014 |
1.62 % |
13/02/2015 |
FIL Limited |
Bermuda |
517014 |
0 |
517014 |
0 |
517014 |
1.62 % |
13/02/2015 |
Capital Research Global Investors |
Delaware |
3778676 |
0 |
3778676 |
0 |
3778676 |
11.9 % |
10/09/2014 |
Capital Research Global Investors |
Delaware |
3778676 |
0 |
3778676 |
0 |
3778676 |
11.9 % |
10/09/2014 |
FMR LLC |
Delaware |
88599 |
0 |
3328532 |
0 |
3328532 |
10.499 % |
09/09/2014 |
Abigail P. Johnson |
United States of America |
0 |
0 |
3328532 |
0 |
3328532 |
10.499 % |
09/09/2014 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
3328532 |
0 |
3328532 |
10.499 % |
09/09/2014 |
FMR LLC |
Delaware |
88599 |
0 |
3328532 |
0 |
3328532 |
10.499 % |
09/09/2014 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
3328532 |
0 |
3328532 |
10.499 % |
09/09/2014 |
Abigail P. Johnson |
United States of America |
0 |
0 |
3328532 |
0 |
3328532 |
10.499 % |
09/09/2014 |
FIL Limited |
Bermuda |
1654028 |
0 |
1654028 |
0 |
1654028 |
5.224 % |
11/08/2014 |
Pandanus Partners, L.P. |
Delaware |
0 |
0 |
1654028 |
0 |
1654028 |
5.224 % |
11/08/2014 |
FIL Limited |
Bermuda |
1654028 |
0 |
1654028 |
0 |
1654028 |
5.224 % |
11/08/2014 |
Pandanus Associates, Inc. |
Delaware |
0 |
0 |
1654028 |
0 |
1654028 |
5.224 % |
11/08/2014 |
Pandanus Partners, L.P. |
Delaware |
0 |
0 |
1654028 |
0 |
1654028 |
5.224 % |
11/08/2014 |
Pandanus Associates, Inc. |
Delaware |
0 |
0 |
1654028 |
0 |
1654028 |
5.224 % |
11/08/2014 |