| JANUS HENDERSON GROUP PLC |
JERSEY |
9766496 |
9766496 |
9766496 |
0 |
9766496 |
4.9 % |
15/05/2026 |
| The Vanguard Group |
PENNSYLVANIA |
0 |
0 |
0 |
0 |
0 |
0 % |
27/03/2026 |
| Baker Bros. Advisors LP |
DELAWARE |
0 |
0 |
0 |
0 |
9455357 |
4.9 % |
17/02/2026 |
| Wellington Management Group LLP |
MASSACHUSETTS |
6987639 |
6987639 |
6987639 |
0 |
6987639 |
3.6 % |
10/02/2026 |
| Farallon Capital Partners, L.P. |
CALIFORNIA |
1057562 |
1057562 |
1057562 |
0 |
1057562 |
0.5 % |
09/02/2026 |
| JANUS HENDERSON GROUP PLC |
JERSEY |
11356054 |
11356054 |
11356054 |
0 |
11356054 |
6.1 % |
14/11/2025 |
| FMR LLC |
DELAWARE |
0 |
0 |
0 |
0 |
9401686 |
5 % |
05/11/2025 |
| Baker Bros. Advisors LP |
DELAWARE |
0 |
0 |
0 |
0 |
9364972 |
5 % |
14/08/2025 |
| JANUS HENDERSON GROUP PLC |
JERSEY |
10590727 |
10590727 |
10590727 |
0 |
10590727 |
5.7 % |
14/08/2025 |
| Wellington Management Group LLP |
MASSACHUSETTS |
10259738 |
10259738 |
10259738 |
0 |
10259738 |
5.5 % |
12/08/2025 |
| BlackRock, Inc. |
DELAWARE |
0 |
0 |
0 |
0 |
8399214 |
4.5 % |
17/07/2025 |
| Farallon Capital Partners, L.P. |
CALIFORNIA |
894594 |
894594 |
894594 |
0 |
894594 |
0.5 % |
15/05/2025 |
| Farallon Capital Partners, L.P. |
CALIFORNIA |
816794 |
816794 |
816794 |
0 |
816794 |
0.5 % |
15/05/2025 |
| Farallon Capital Partners, L.P. |
CALIFORNIA |
441274 |
441274 |
441274 |
0 |
441274 |
0.3 % |
15/05/2025 |
| JANUS HENDERSON GROUP PLC |
JERSEY |
10209927 |
10209927 |
10209927 |
0 |
10209927 |
5.5 % |
14/05/2025 |
| JANUS HENDERSON GROUP PLC |
JERSEY |
9483999 |
9483999 |
9483999 |
0 |
9483999 |
5.2 % |
14/02/2025 |
| Rajiv A. Patel |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Daniel S. Short |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Farallon Capital F5 Master I, L.P. |
Cayman Islands |
0 |
261854 |
0 |
0 |
261854 |
0.2 % |
09/11/2023 |
| Farallon Capital (AM) Investors, L.P. |
Delaware |
0 |
63915 |
0 |
0 |
63915 |
0.1 % |
09/11/2023 |
| Farallon Capital Offshore Investors II, L.P. |
Cayman Islands |
0 |
1196910 |
0 |
0 |
1196910 |
1.1 % |
09/11/2023 |
| Richard B. Fried |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Varun N. Gehani |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Four Crossings Institutional Partners V, L.P. |
Delaware |
0 |
118780 |
0 |
0 |
118780 |
0.1 % |
09/11/2023 |
| Farallon Capital Institutional Partners III, L.P. |
Delaware |
0 |
90032 |
0 |
0 |
90032 |
0.1 % |
09/11/2023 |
| Farallon Capital Institutional Partners II, L.P. |
California |
0 |
205353 |
0 |
0 |
205353 |
0.2 % |
09/11/2023 |
| Farallon Capital Institutional Partners, L.P. |
California |
0 |
761700 |
0 |
0 |
761700 |
0.7 % |
09/11/2023 |
| Farallon Capital Partners, L.P. |
California |
0 |
291600 |
0 |
0 |
291600 |
0.3 % |
09/11/2023 |
| William Seybold |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| John R. Warren |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Michael G. Linn |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| David T. Kim |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Mark C. Wehrly |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Nicolas Giauque |
France |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Hannah E. Dunn |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Philip D. Dreyfuss |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Joshua J. Dapice |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Thomas G. Roberts, Jr. |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Edric C. Saito |
United States |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Andrew J. M. Spokes |
United Kingdom |
0 |
6762480 |
0 |
0 |
6762480 |
6.2 % |
09/11/2023 |
| Farallon Healthcare Partners (GP), L.L.C. |
Delaware |
0 |
3772336 |
0 |
0 |
3772336 |
3.4 % |
09/11/2023 |
| Farallon F5 (GP), L.L.C. |
Delaware |
0 |
261854 |
0 |
0 |
261854 |
0.2 % |
09/11/2023 |
| Farallon Institutional (GP) V, L.L.C. |
Delaware |
0 |
118780 |
0 |
0 |
118780 |
0.1 % |
09/11/2023 |
| Farallon Partners, L.L.C. |
Delaware |
0 |
6500626 |
0 |
0 |
6500626 |
5.9 % |
09/11/2023 |
| Farallon Healthcare Partners Master, L.P. |
Cayman Islands |
0 |
3772336 |
0 |
0 |
3772336 |
3.4 % |
09/11/2023 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
7555588 |
7555588 |
7.1 % |
30/06/2023 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
7555588 |
7555588 |
7.1 % |
30/06/2023 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
2532481 |
2532481 |
2.4 % |
30/06/2023 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
294786 |
294786 |
1 % |
30/06/2023 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
294786 |
294786 |
1 % |
30/06/2023 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
7555588 |
7555588 |
7.1 % |
30/06/2023 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
2532481 |
2532481 |
2.4 % |
30/06/2023 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
4641604 |
4641604 |
4.4 % |
30/06/2023 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
4641604 |
4641604 |
4.4 % |
30/06/2023 |
| BVF GP Holdings LLC |
Delaware |
0 |
0 |
0 |
7174085 |
7174085 |
6.7 % |
30/06/2023 |
| Oleg Nodelman |
Delaware |
0 |
4478050 |
0 |
4478050 |
4478050 |
11 % |
23/01/2023 |
| EcoR1 Capital, LLC |
Delaware |
0 |
4478050 |
0 |
4478050 |
4478050 |
11 % |
23/01/2023 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
4216024 |
0 |
4216024 |
4216024 |
11 % |
23/01/2023 |
| BB Biotech AG |
Switzerland |
0 |
4602562 |
0 |
4602562 |
4602562 |
5.2 % |
29/09/2022 |
| Biotech Growth N.V. |
Switzerland |
0 |
4602562 |
0 |
4602562 |
4602562 |
5.2 % |
29/09/2022 |
| Oleg Nodelman |
United States |
0 |
4278069 |
0 |
4278069 |
4278069 |
11 % |
27/06/2022 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
4028251 |
0 |
4028251 |
4028251 |
11 % |
27/06/2022 |
| EcoR1 Capital, LLC |
Delaware |
0 |
4278069 |
0 |
4278069 |
4278069 |
11 % |
27/06/2022 |
| Kevin P. Starr |
|
129256 |
5524031 |
129256 |
5524031 |
5653287 |
7.7 % |
14/02/2022 |
| Mark Levin |
|
129259 |
5524031 |
129259 |
5524031 |
5653290 |
7.7 % |
14/02/2022 |
| Third Rock Ventures IV, L.P. |
|
0 |
1419900 |
0 |
1419900 |
1419900 |
1.9 % |
14/02/2022 |
| Robert I. Tepper |
|
129258 |
5524031 |
129258 |
5524031 |
5653289 |
7.7 % |
14/02/2022 |
| TRV GP IV, LLC |
|
0 |
1419900 |
0 |
1419900 |
1419900 |
1.9 % |
14/02/2022 |
| Third Rock Ventures GP IV, L.P. |
|
0 |
1419900 |
0 |
1419900 |
1419900 |
1.9 % |
14/02/2022 |
| TRV GP III, LLC |
|
0 |
5524031 |
0 |
5524031 |
5524031 |
7.5 % |
14/02/2022 |
| Third Rock Ventures GP III, L.P. |
|
0 |
5524031 |
0 |
5524031 |
5524031 |
7.5 % |
14/02/2022 |
| Third Rock Ventures III, L.P. |
|
0 |
5524031 |
0 |
5524031 |
5524031 |
7.5 % |
14/02/2022 |
| Ponoi Capital, LP |
|
0 |
685011 |
0 |
685011 |
685011 |
0.9 % |
11/02/2022 |
| III-A, |
|
0 |
1775236 |
0 |
1775236 |
1775236 |
2.4 % |
11/02/2022 |
| The Column Group III, LP |
|
0 |
1571963 |
0 |
1571963 |
1571963 |
2.1 % |
11/02/2022 |
| The Column Group, LLC |
|
0 |
46 |
0 |
46 |
46 |
0 % |
11/02/2022 |
| Ponoi II Management, LLC |
|
0 |
685011 |
0 |
685011 |
685011 |
0.9 % |
11/02/2022 |
| Ponoi Capital II, LP |
|
0 |
685011 |
0 |
685011 |
685011 |
0.9 % |
11/02/2022 |
| Ponoi Management, LLC |
|
0 |
685011 |
0 |
685011 |
685011 |
0.9 % |
11/02/2022 |
| The Column Group III GP, LP |
|
0 |
3347199 |
0 |
3347199 |
3347199 |
4.5 % |
11/02/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania For |
0 |
56084 |
6198079 |
101530 |
6299609 |
8.55 % |
10/02/2022 |
| Wellington Management Company LLP |
|
0 |
3985923 |
0 |
0 |
4235526 |
5.75 % |
04/02/2022 |
| Wellington Management Group LLP |
|
0 |
4078428 |
0 |
0 |
4510895 |
6.12 % |
04/02/2022 |
| Wellington Investment Advisors Holdings LLP |
|
0 |
4078428 |
0 |
0 |
4510895 |
6.12 % |
04/02/2022 |
| Wellington Group Holdings LLP |
|
0 |
4078428 |
0 |
0 |
4510895 |
6.12 % |
04/02/2022 |
| Bihua Chen |
United States |
0 |
3675000 |
0 |
3675000 |
3675000 |
5 % |
19/05/2021 |
| Cormorant Private Healthcare GP II, LLC |
Delaware |
0 |
1545066 |
0 |
1545066 |
1545066 |
2.1 % |
19/05/2021 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
2047079 |
0 |
2047079 |
2047079 |
2.8 % |
19/05/2021 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
2047079 |
0 |
2047079 |
2047079 |
2.8 % |
19/05/2021 |
| Cormorant Private Healthcare Fund II, LP |
Delaware |
0 |
1545066 |
0 |
1545066 |
1545066 |
2.1 % |
19/05/2021 |
| Cormorant Asset Management, LP |
Delaware |
0 |
3675000 |
0 |
3675000 |
3675000 |
5 % |
19/05/2021 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
3443597 |
3443597 |
4.7 % |
17/05/2021 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
3757049 |
3757049 |
5.1 % |
17/05/2021 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
3757049 |
3757049 |
5.1 % |
17/05/2021 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
1966302 |
1966302 |
2.7 % |
17/05/2021 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
1966302 |
1966302 |
2.7 % |
17/05/2021 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
3757049 |
3757049 |
5.1 % |
17/05/2021 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
1477295 |
1477295 |
2 % |
17/05/2021 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
1477295 |
1477295 |
2 % |
17/05/2021 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
237782 |
237782 |
1 % |
17/05/2021 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
237782 |
237782 |
1 % |
17/05/2021 |
| MVA Investors, LLC |
Delaware |
0 |
35414 |
0 |
35414 |
35414 |
0 % |
16/02/2021 |
| Aaron I. Davis |
Delaware |
0 |
35414 |
0 |
35414 |
35414 |
0 % |
16/02/2021 |
| Boxer Asset Management Inc. |
Delaware |
0 |
3309264 |
0 |
3309264 |
3309264 |
4.6 % |
16/02/2021 |
| Boxer Capital, LLC |
Delaware |
0 |
3309264 |
0 |
3309264 |
3309264 |
4.6 % |
16/02/2021 |
| Joe Lewis |
Delaware |
0 |
3309264 |
0 |
3309264 |
3309264 |
4.6 % |
16/02/2021 |
| TRV GP IV, LLC |
Delaware |
0 |
1419900 |
0 |
1419900 |
1419900 |
2.1 % |
16/02/2021 |
| Third Rock Ventures GP III, L.P. |
Delaware |
0 |
7024031 |
0 |
7024031 |
7024031 |
10.6 % |
16/02/2021 |
| Third Rock Ventures III, L.P. |
Delaware |
0 |
7024031 |
0 |
7024031 |
7024031 |
10.6 % |
16/02/2021 |
| Kevin P. Starr |
Delaware |
15720 |
8933348 |
15720 |
8933348 |
8949068 |
13.5 % |
16/02/2021 |
| Robert I. Tepper |
Delaware |
15720 |
8933348 |
15720 |
8933348 |
8949068 |
13.5 % |
16/02/2021 |
| TRV GP III, LLC |
Delaware |
0 |
7024031 |
0 |
7024031 |
7024031 |
10.6 % |
16/02/2021 |
| Third Rock Ventures IV, L.P. |
Delaware |
0 |
1419900 |
0 |
1419900 |
1419900 |
2.1 % |
16/02/2021 |
| Mark Levin |
Delaware |
15721 |
8933348 |
15721 |
8933348 |
8949069 |
13.5 % |
16/02/2021 |
| Third Rock Ventures GP IV, L.P. |
Delaware |
0 |
1419900 |
0 |
1419900 |
1419900 |
2.1 % |
16/02/2021 |
| TRV GP II, LLC |
Delaware |
0 |
1909317 |
0 |
1909317 |
1909317 |
2.9 % |
16/02/2021 |
| Third Rock Ventures GP II, L.P. |
Delaware |
0 |
1909317 |
0 |
1909317 |
1909317 |
2.9 % |
16/02/2021 |
| Third Rock Ventures II, L.P. |
Delaware |
0 |
1909317 |
0 |
1909317 |
1909317 |
2.9 % |
16/02/2021 |
| Cormorant Asset Management, LP |
Delaware |
0 |
2495066 |
0 |
2495066 |
2495066 |
3.8 % |
16/02/2021 |
| Cormorant Private Healthcare GP II, LLC |
Delaware |
0 |
1545066 |
0 |
1545066 |
1545066 |
2.3 % |
16/02/2021 |
| Bihua Chen |
United States |
0 |
2495066 |
0 |
2495066 |
2495066 |
3.8 % |
16/02/2021 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
889287 |
0 |
889287 |
889287 |
1.3 % |
16/02/2021 |
| Cormorant Private Healthcare Fund II, LP |
Delaware |
0 |
1545066 |
0 |
1545066 |
1545066 |
2.3 % |
16/02/2021 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
889287 |
0 |
889287 |
889287 |
1.3 % |
16/02/2021 |
| The Column Group, LLC |
Delaware |
0 |
46 |
0 |
46 |
46 |
0 % |
12/02/2021 |
| Ponoi Capital II, LP |
Delaware |
0 |
685011 |
0 |
685011 |
685011 |
0.9 % |
12/02/2021 |
| Ponoi II Management, LLC |
Delaware |
0 |
685011 |
0 |
685011 |
685011 |
0.9 % |
12/02/2021 |
| Ponoi Management, LLC |
Delaware |
0 |
685011 |
0 |
685011 |
685011 |
0.9 % |
12/02/2021 |
| Ponoi Capital, LP |
Delaware |
0 |
685011 |
0 |
685011 |
685011 |
0.9 % |
12/02/2021 |
| The Column Group III, LP |
Delaware |
0 |
1681391 |
0 |
1681391 |
1681391 |
2.3 % |
12/02/2021 |
| III-A, |
Delaware |
0 |
1898815 |
0 |
1898815 |
1898815 |
2.6 % |
12/02/2021 |
| The Column Group III GP, LP |
Delaware |
0 |
3580206 |
0 |
3580206 |
3580206 |
4.9 % |
12/02/2021 |
| SANOFI |
Republic France |
3363050 |
0 |
3363050 |
0 |
3363050 |
4.6 % |
11/02/2021 |
| The Vanguard Group - 23-1945930 |
Pennsylvania For |
0 |
82869 |
3933661 |
104159 |
4037820 |
6.08 % |
10/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
3460483 |
0 |
3512087 |
0 |
3512087 |
5.3 % |
02/02/2021 |
| Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
1593941 |
0 |
1593941 |
1593941 |
2.7 % |
24/02/2020 |
| Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
1593941 |
0 |
1593941 |
1593941 |
2.7 % |
24/02/2020 |
| Cormorant Private Healthcare GP II, LLC |
Delaware |
0 |
1545066 |
0 |
1545066 |
1545066 |
2.62 % |
24/02/2020 |
| Cormorant Private Healthcare Fund II, LP |
Delaware |
0 |
1545066 |
0 |
1545066 |
1545066 |
2.62 % |
24/02/2020 |
| Cormorant Asset Management, LP |
Delaware |
0 |
3245177 |
0 |
3245177 |
3245177 |
5.5 % |
24/02/2020 |
| Bihua Chen |
United States |
0 |
3245177 |
0 |
3245177 |
3245177 |
5.5 % |
24/02/2020 |
| Deerfield Partners, L.P. |
Delaware |
0 |
798795 |
0 |
0 |
798795 |
1.4 % |
18/02/2020 |
| Company, L.P. |
Delaware |
0 |
2096384 |
0 |
0 |
2096384 |
3.68 % |
18/02/2020 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
798795 |
0 |
0 |
798795 |
1.4 % |
18/02/2020 |
| Deerfield Mgmt IV, L.P. |
Delaware |
0 |
1297589 |
0 |
0 |
1297589 |
2.28 % |
18/02/2020 |
| Deerfield Private Design Fund IV, L.P. |
Delaware |
0 |
1297589 |
0 |
0 |
1297589 |
2.28 % |
18/02/2020 |
| James E. Flynn |
Delaware |
0 |
2096384 |
0 |
0 |
2096384 |
3.68 % |
18/02/2020 |
| Boxer Capital, LLC |
Delaware |
0 |
3259764 |
0 |
3259764 |
3259764 |
5.7 % |
13/02/2020 |
| Joe Lewis |
Delaware |
0 |
3259764 |
0 |
3259764 |
3259764 |
5.7 % |
13/02/2020 |
| MVA Investors, LLC |
Delaware |
0 |
35414 |
0 |
35414 |
35414 |
0.1 % |
13/02/2020 |
| Aaron I. Davis |
Delaware |
0 |
35414 |
0 |
35414 |
35414 |
0.1 % |
13/02/2020 |
| Boxer Asset Management Inc. |
Delaware |
0 |
3259764 |
0 |
3259764 |
3259764 |
5.7 % |
13/02/2020 |
| Boxer Asset Management Inc. |
|
0 |
3159764 |
0 |
3159764 |
3159764 |
5.6 % |
13/02/2020 |
| MVA Investors, LLC |
|
0 |
35414 |
0 |
35414 |
35414 |
0.1 % |
13/02/2020 |
| Joe Lewis |
|
0 |
3159764 |
0 |
3159764 |
3159764 |
5.6 % |
13/02/2020 |
| Boxer Capital, LLC |
|
0 |
3159764 |
0 |
3159764 |
3159764 |
5.6 % |
13/02/2020 |
| Aaron I. Davis |
|
0 |
35414 |
0 |
35414 |
35414 |
0.1 % |
13/02/2020 |