Avidity Partners Management LP |
Delaware |
0 |
4040810 |
0 |
4040810 |
4040810 |
9.9 % |
14/11/2024 |
Michael Gregory |
United States of America |
0 |
4040810 |
0 |
4040810 |
4040810 |
9.9 % |
14/11/2024 |
David Witzke |
United States of America |
0 |
4040810 |
0 |
4040810 |
4040810 |
9.9 % |
14/11/2024 |
Avidity Private Master Fund I LP |
Cayman Islands |
0 |
4065207 |
0 |
4065207 |
4065207 |
9.9 % |
14/11/2024 |
Avidity Master Fund LP |
Cayman Islands |
0 |
4177203 |
0 |
4177203 |
4177203 |
9.9 % |
14/11/2024 |
Avidity Capital Partners |
Delaware |
0 |
4040810 |
0 |
4040810 |
4040810 |
9.9 % |
14/11/2024 |
Avidity Capital Partners Fund |
Delaware |
0 |
4040810 |
0 |
4040810 |
4040810 |
9.9 % |
14/11/2024 |
Avidity Partners Management |
Delaware |
0 |
4040810 |
0 |
4040810 |
4040810 |
9.9 % |
14/11/2024 |
J. Christopher Donahue |
United States |
|
7128250 |
|
7128250 |
7128250 |
17.22 % |
06/11/2024 |
Ann C. Donahue |
United States |
|
7128250 |
|
7128250 |
7128250 |
17.22 % |
06/11/2024 |
Thomas R. Donahue |
United States |
|
7128250 |
|
7128250 |
7128250 |
17.22 % |
06/11/2024 |
Voting Shares Irrevocable Trust |
Pennsylvania |
7128250 |
|
7128250 |
|
7128250 |
17.22 % |
06/11/2024 |
Federated Hermes, Inc. |
Pennsylvania |
7128250 |
|
7128250 |
|
7128250 |
17.22 % |
06/11/2024 |
Federated Hermes, Inc. |
Pennsylvania |
7128250 |
|
7128250 |
|
7128250 |
18.83 % |
07/10/2024 |
Voting Shares Irrevocable Trust |
Pennsylvania |
7128250 |
|
7128250 |
|
7128250 |
18.83 % |
07/10/2024 |
Thomas R. Donahue |
United States |
|
7128250 |
|
7128250 |
7128250 |
18.83 % |
07/10/2024 |
Ann C. Donahue |
United States |
|
7128250 |
|
7128250 |
7128250 |
18.83 % |
07/10/2024 |
J. Christopher Donahue |
United States |
|
7128250 |
|
7128250 |
7128250 |
18.83 % |
07/10/2024 |
Caxton Corporation |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2024 |
CDK Associates, L.L.C. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2024 |
Bruce S. Kovner |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2024 |
Avidity Capital Partners Fund |
Delaware |
0 |
3968816 |
0 |
3968816 |
3968816 |
9.9 % |
13/02/2024 |
Avidity Partners Management LP |
Delaware |
0 |
3968816 |
0 |
3968816 |
3968816 |
9.9 % |
13/02/2024 |
Avidity Partners Management |
Delaware |
0 |
3968816 |
0 |
3968816 |
3968816 |
9.9 % |
13/02/2024 |
Avidity Capital Partners |
Delaware |
0 |
3968816 |
0 |
3968816 |
3968816 |
9.9 % |
13/02/2024 |
Avidity Master Fund LP |
Cayman Islands |
0 |
4105210 |
0 |
4105210 |
4105210 |
9.9 % |
13/02/2024 |
Avidity Private Master Fund I LP |
Cayman Islands |
0 |
3993213 |
0 |
3993213 |
3993213 |
9.9 % |
13/02/2024 |
David Witzke |
United States of America |
0 |
3968816 |
0 |
3968816 |
3968816 |
9.9 % |
13/02/2024 |
Michael Gregory |
United States of America |
0 |
3968816 |
0 |
3968816 |
3968816 |
9.9 % |
13/02/2024 |
Stonepine Capital, L.P. |
Delaware |
0 |
1355186 |
0 |
1355186 |
1355186 |
3.6 % |
13/02/2024 |
Stonepine Capital Management, LLC |
California |
0 |
1355186 |
0 |
1355186 |
1355186 |
3.6 % |
13/02/2024 |
Thomas R. Donahue |
United States |
|
8094700 |
|
8094700 |
8094700 |
19.99 % |
18/01/2024 |
Ann C. Donahue |
United States |
|
8094700 |
|
8094700 |
8094700 |
19.99 % |
18/01/2024 |
Voting Shares Irrevocable Trust |
Pennsylvania |
8094700 |
|
8094700 |
|
8094700 |
19.99 % |
18/01/2024 |
Federated Hermes, Inc. |
Pennsylvania |
8094700 |
|
8094700 |
|
8094700 |
19.99 % |
18/01/2024 |
J. Christopher Donahue |
United States |
|
8094700 |
|
8094700 |
8094700 |
19.99 % |
18/01/2024 |
Kingdon GP, LLC |
Delaware |
0 |
1982491 |
0 |
1982491 |
1982491 |
5.33 % |
29/11/2023 |
Mark Kingdon |
United States of America |
0 |
2237048 |
0 |
2237048 |
2237048 |
6.02 % |
29/11/2023 |
M. Kingdon Offshore Master Fund L.P. |
Cayman Islands |
0 |
1982491 |
0 |
1982491 |
1982491 |
5.33 % |
29/11/2023 |
Kingdon Capital Management, L.L.C. |
Delaware |
0 |
2237048 |
0 |
2237048 |
2237048 |
6.02 % |
29/11/2023 |
M. Kingdon Offshore Master Fund L.P. |
Cayman Islands |
0 |
1982491 |
0 |
1982491 |
1982491 |
5.33 % |
29/11/2023 |
Kingdon GP, LLC |
Delaware |
0 |
1982491 |
0 |
1982491 |
1982491 |
5.33 % |
29/11/2023 |
Kingdon Capital Management, L.L.C. |
Delaware |
0 |
2237048 |
0 |
2237048 |
2237048 |
6.02 % |
29/11/2023 |
Mark Kingdon |
United States of America |
0 |
2237048 |
0 |
2237048 |
2237048 |
6.02 % |
29/11/2023 |
Stonepine Capital, L.P. |
Delaware |
0 |
2777877 |
0 |
2777877 |
2777877 |
7.6 % |
09/06/2023 |
Stonepine Capital, L.P. |
Delaware |
0 |
2777877 |
0 |
2777877 |
2777877 |
7.6 % |
09/06/2023 |
Stonepine Capital Management, LLC |
California |
0 |
2777877 |
0 |
2777877 |
2777877 |
7.6 % |
09/06/2023 |
Stonepine Capital Management, LLC |
California |
0 |
2777877 |
0 |
2777877 |
2777877 |
7.6 % |
09/06/2023 |
Kingdon Capital Management, L.L.C. |
Delaware |
0 |
1697048 |
0 |
1697048 |
1697048 |
5.1 % |
13/04/2023 |
Mark Kingdon |
United States of America |
0 |
1697048 |
0 |
1697048 |
1697048 |
5.1 % |
13/04/2023 |
Mark Kingdon |
United States of America |
0 |
1697048 |
0 |
1697048 |
1697048 |
5.1 % |
13/04/2023 |
Kingdon Capital Management, L.L.C. |
Delaware |
0 |
1697048 |
0 |
1697048 |
1697048 |
5.1 % |
13/04/2023 |
AIGH Capital Management, LLC |
Maryland |
1159346 |
0 |
1159346 |
|
1159346 |
3.5 % |
03/04/2023 |
Orin Hirschman |
United States |
1159346 |
|
1159346 |
|
1159346 |
3.5 % |
03/04/2023 |
AIGH Capital Management, LLC . |
Maryland |
1932046 |
0 |
1932046 |
0 |
1932046 |
5.3 % |
15/02/2023 |
Orin Hchman . |
United States |
1932046 |
0 |
1932046 |
0 |
1932046 |
5.3 % |
15/02/2023 |
Federated Hermes, Inc. |
Pennsylvania |
6866914 |
|
6866914 |
|
6866914 |
19.99 % |
01/02/2023 |
Voting Shares Irrevocable Trust |
Pennsylvania |
6866914 |
|
6866914 |
|
6866914 |
19.99 % |
01/02/2023 |
Thomas R. Donahue |
United States |
|
6866914 |
|
6866914 |
6866914 |
19.99 % |
01/02/2023 |
J. Christopher Donahue |
United States |
|
6866914 |
|
6866914 |
6866914 |
19.99 % |
01/02/2023 |
Joseph Edelman |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
Perceptive Life Sciences Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
Perceptive Advisors LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2022 |
Caxton Corporation |
Delaware |
0 |
2210672 |
0 |
2210672 |
2210672 |
9 % |
14/02/2022 |
CDK Associates, L.L.C. |
Delaware |
0 |
2210672 |
0 |
2210672 |
2210672 |
9 % |
14/02/2022 |
Bruce S. Kovner |
United States |
0 |
2210672 |
0 |
2210672 |
2210672 |
9 % |
14/02/2022 |
CDK Associates, L.L.C. |
Delaware |
0 |
2210672 |
0 |
2210672 |
2210672 |
9 % |
14/02/2022 |
Bruce S. Kovner |
United States |
0 |
2210672 |
0 |
2210672 |
2210672 |
9 % |
14/02/2022 |
Caxton Corporation |
Delaware |
0 |
2210672 |
0 |
2210672 |
2210672 |
9 % |
14/02/2022 |
J. Christopher Donahue |
|
|
5915664 |
|
5915664 |
5915664 |
19.99 % |
14/02/2022 |
Rhodora J. Donahue |
|
|
5915664 |
|
5915664 |
5915664 |
19.99 % |
14/02/2022 |
Voting Shares Irrevocable Trust |
|
5915664 |
|
5915664 |
|
5915664 |
19.99 % |
14/02/2022 |
Thomas R. Donahue |
|
|
5915664 |
|
5915664 |
5915664 |
19.99 % |
14/02/2022 |
(entities only Federated Hermes, Inc. |
|
5915664 |
|
5915664 |
|
5915664 |
19.99 % |
14/02/2022 |
Timothy P. Lynch |
U.S.A. |
385650 |
0 |
385650 |
0 |
385650 |
1.6 % |
11/02/2022 |
Stonepine Capital, L.P. |
Delaware |
385650 |
0 |
385650 |
0 |
385650 |
1.6 % |
11/02/2022 |
Stonepine Capital Management, LLC |
California |
385650 |
0 |
385650 |
0 |
385650 |
1.6 % |
11/02/2022 |
Stonepine Capital Management, LLC |
California |
385650 |
0 |
385650 |
0 |
385650 |
1.6 % |
11/02/2022 |
Stonepine Capital, L.P. |
Delaware |
385650 |
0 |
385650 |
0 |
385650 |
1.6 % |
11/02/2022 |
Jon M. Plexico |
U.S.A. |
385650 |
0 |
385650 |
0 |
385650 |
1.6 % |
11/02/2022 |
Timothy P. Lynch |
U.S.A. |
385650 |
0 |
385650 |
0 |
385650 |
1.6 % |
11/02/2022 |
Jon M. Plexico |
U.S.A. |
385650 |
0 |
385650 |
0 |
385650 |
1.6 % |
11/02/2022 |
(entities only Federated Hermes, Inc. |
|
5449253 |
|
5449253 |
|
5449253 |
19.98 % |
10/12/2021 |
Thomas R. Donahue |
|
|
5449253 |
|
5449253 |
5449253 |
19.98 % |
10/12/2021 |
Voting Shares Irrevocable Trust |
|
5449253 |
|
5449253 |
|
5449253 |
19.98 % |
10/12/2021 |
J. Christopher Donahue |
|
|
5449253 |
|
5449253 |
5449253 |
19.98 % |
10/12/2021 |
Rhodora J. Donahue |
|
|
5449253 |
|
5449253 |
5449253 |
19.98 % |
10/12/2021 |
Orin Hirschman |
United States |
2048730 |
|
2048730 |
|
2048730 |
8.6 % |
12/11/2021 |
AIGH Capital Management, LLC |
Maryland |
2048730 |
0 |
2048730 |
|
2048730 |
8.6 % |
12/11/2021 |
Orin Hirschman |
United States |
1345394 |
|
1345394 |
|
1345394 |
6.5 % |
10/06/2021 |
AIGH Capital Management, LLC |
Maryland |
1345394 |
0 |
1345394 |
|
1345394 |
6.5 % |
10/06/2021 |
(entities only Federated Hermes, Inc. |
|
2129553 |
|
2129553 |
|
2129553 |
11.05 % |
10/03/2021 |
Thomas R. Donahue |
|
|
2129553 |
|
2129553 |
2129553 |
11.05 % |
10/03/2021 |
Rhodora J. Donahue |
|
|
2129553 |
|
2129553 |
2129553 |
11.05 % |
10/03/2021 |
J. Christopher Donahue |
|
|
2129553 |
|
2129553 |
2129553 |
11.05 % |
10/03/2021 |
Voting Shares Irrevocable Trust |
|
2129553 |
|
2129553 |
|
2129553 |
11.05 % |
10/03/2021 |
Bruce S. Kovner |
United States |
0 |
1474370 |
0 |
1474370 |
1474370 |
7.5 % |
16/02/2021 |
Caxton Corporation |
Delaware |
0 |
1474370 |
0 |
1474370 |
1474370 |
7.5 % |
16/02/2021 |
CDK Associates, L.L.C. |
Delaware |
0 |
1474370 |
0 |
1474370 |
1474370 |
7.5 % |
16/02/2021 |
Bruce S. Kovner |
United States |
0 |
1474370 |
0 |
1474370 |
1474370 |
7.5 % |
16/02/2021 |
Caxton Corporation |
Delaware |
0 |
1474370 |
0 |
1474370 |
1474370 |
7.5 % |
16/02/2021 |
CDK Associates, L.L.C. |
Delaware |
0 |
1474370 |
0 |
1474370 |
1474370 |
7.5 % |
16/02/2021 |
Avidity Capital Partners Fund |
Delaware |
0 |
1964960 |
0 |
1964960 |
1964960 |
9.9 % |
16/02/2021 |
Avidity Capital Partners |
Delaware |
0 |
1964960 |
0 |
1964960 |
1964960 |
9.9 % |
16/02/2021 |
Avidity Master Fund LP |
Cayman Islands |
0 |
1979800 |
0 |
1979800 |
1979800 |
9.9 % |
16/02/2021 |
David Witzke |
United States of America |
0 |
1964960 |
0 |
1964960 |
1964960 |
9.9 % |
16/02/2021 |
Michael Gregory |
United States of America |
0 |
1964960 |
0 |
1964960 |
1964960 |
9.9 % |
16/02/2021 |
Avidity Partners Management LP |
Delaware |
0 |
1964960 |
0 |
1964960 |
1964960 |
9.9 % |
16/02/2021 |
Avidity Partners Management |
Delaware |
0 |
1964960 |
0 |
1964960 |
1964960 |
9.9 % |
16/02/2021 |
Jon M. Plexico |
U.S.A. |
1530650 |
0 |
1530650 |
0 |
1530650 |
7.7 % |
12/02/2021 |
Timothy P. Lynch |
U.S.A. |
1530650 |
0 |
1530650 |
0 |
1530650 |
7.7 % |
12/02/2021 |
Stonepine Capital Management, LLC |
California |
1530650 |
0 |
1530650 |
0 |
1530650 |
7.7 % |
12/02/2021 |
Stonepine Capital, L.P. |
Delaware |
1530650 |
0 |
1530650 |
0 |
1530650 |
7.7 % |
12/02/2021 |
Stonepine Capital, L.P. |
Delaware |
1530650 |
0 |
1530650 |
0 |
1530650 |
7.7 % |
12/02/2021 |
Jon M. Plexico |
U.S.A. |
1530650 |
0 |
1530650 |
0 |
1530650 |
7.7 % |
12/02/2021 |
Stonepine Capital Management, LLC |
California |
1530650 |
0 |
1530650 |
0 |
1530650 |
7.7 % |
12/02/2021 |
Timothy P. Lynch |
U.S.A. |
1530650 |
0 |
1530650 |
0 |
1530650 |
7.7 % |
12/02/2021 |
Voting Shares Irrevocable Trust |
|
2129553 |
|
2129553 |
|
2129553 |
19.47 % |
12/02/2021 |
J. Christopher Donahue |
|
|
2129553 |
|
2129553 |
2129553 |
19.47 % |
12/02/2021 |
(entities only Federated Hermes, Inc. |
|
2129553 |
|
2129553 |
|
2129553 |
19.47 % |
12/02/2021 |
Thomas R. Donahue |
|
|
2129553 |
|
2129553 |
2129553 |
19.47 % |
12/02/2021 |
Rhodora J. Donahue |
|
|
2129553 |
|
2129553 |
2129553 |
19.47 % |
12/02/2021 |
Puissance Capital Management LP |
Delaware |
0 |
255718 |
0 |
255718 |
255718 |
2.34 % |
11/02/2021 |
Puissance Capital Fund LLC |
Delaware |
0 |
255718 |
0 |
255718 |
255718 |
2.34 % |
11/02/2021 |
Puissance Life Science Opportunities Fund VI |
Cayman Islands |
0 |
255718 |
0 |
255718 |
255718 |
2.34 % |
11/02/2021 |
Theodore Wang |
United States America |
0 |
255718 |
0 |
255718 |
255718 |
2.34 % |
11/02/2021 |
Puissance Capital Management LLC |
Delaware |
0 |
255718 |
0 |
255718 |
255718 |
2.34 % |
11/02/2021 |
Perceptive Advisors LLC |
Delaware |
0 |
1300000 |
0 |
1300000 |
1300000 |
6.8 % |
27/01/2021 |
Joseph Edelman |
United States of America |
0 |
1300000 |
0 |
1300000 |
1300000 |
6.8 % |
27/01/2021 |
Perceptive Life Sciences Master Fund, Ltd. |
Cayman Islands |
0 |
1300000 |
0 |
1300000 |
1300000 |
6.8 % |
27/01/2021 |
Timothy P. Lynch |
U.S.A. |
1536953 |
0 |
1536953 |
0 |
1536953 |
7.7 % |
23/12/2020 |
Stonepine Capital Management, LLC |
California |
1536953 |
0 |
1536953 |
0 |
1536953 |
7.7 % |
23/12/2020 |
Stonepine Capital, L.P. |
Delaware |
1536953 |
0 |
1536953 |
0 |
1536953 |
7.7 % |
23/12/2020 |
Jon M. Plexico |
U.S.A. |
1536953 |
0 |
1536953 |
0 |
1536953 |
7.7 % |
23/12/2020 |
Timothy P. Lynch |
U.S.A. |
1536953 |
0 |
1536953 |
0 |
1536953 |
7.7 % |
23/12/2020 |
Stonepine Capital, L.P. |
Delaware |
1536953 |
0 |
1536953 |
0 |
1536953 |
7.7 % |
23/12/2020 |
Jon M. Plexico |
U.S.A. |
1536953 |
0 |
1536953 |
0 |
1536953 |
7.7 % |
23/12/2020 |
Stonepine Capital Management, LLC |
California |
1536953 |
0 |
1536953 |
0 |
1536953 |
7.7 % |
23/12/2020 |
Avidity Capital Partners Fund (GP) LP |
Delaware |
0 |
1086706 |
0 |
1086706 |
1086706 |
9.9 % |
23/12/2020 |
David Witzke |
United States of America |
0 |
1086706 |
0 |
1086706 |
1086706 |
9.9 % |
23/12/2020 |
Michael Gregory |
United States of America |
0 |
1086706 |
0 |
1086706 |
1086706 |
9.9 % |
23/12/2020 |
Avidity Partners Management LP |
Delaware |
0 |
1086706 |
0 |
1086706 |
1086706 |
9.9 % |
23/12/2020 |
Avidity Master Fund LP |
Cayman Islands |
0 |
1097254 |
0 |
1097254 |
1097254 |
9.9 % |
23/12/2020 |
Avidity Partners Management (GP) LLC |
Delaware |
0 |
1086706 |
0 |
1086706 |
1086706 |
9.9 % |
23/12/2020 |
Michael Gregory |
United States of America |
0 |
1086706 |
0 |
1086706 |
1086706 |
9.9 % |
23/12/2020 |
David Witzke |
United States of America |
0 |
1086706 |
0 |
1086706 |
1086706 |
9.9 % |
23/12/2020 |
Avidity Master Fund LP |
Cayman Islands |
0 |
1097254 |
0 |
1097254 |
1097254 |
9.9 % |
23/12/2020 |
Avidity Capital Partners (GP) LLC |
Delaware |
0 |
1086706 |
0 |
1086706 |
1086706 |
9.9 % |
23/12/2020 |
Avidity Capital Partners Fund (GP) LP |
Delaware |
0 |
1086706 |
0 |
1086706 |
1086706 |
9.9 % |
23/12/2020 |
Avidity Partners Management (GP) LLC |
Delaware |
0 |
1086706 |
0 |
1086706 |
1086706 |
9.9 % |
23/12/2020 |
Avidity Capital Partners (GP) LLC |
Delaware |
0 |
1086706 |
0 |
1086706 |
1086706 |
9.9 % |
23/12/2020 |
Avidity Partners Management LP |
Delaware |
0 |
1086706 |
0 |
1086706 |
1086706 |
9.9 % |
23/12/2020 |
Caxton Corporation |
Delaware |
0 |
7936111 |
0 |
7936111 |
7936111 |
8.2 % |
14/02/2020 |
Bruce S. Kovner |
United States |
0 |
7936111 |
0 |
7936111 |
7936111 |
8.2 % |
14/02/2020 |
CDK Associates, L.L.C. |
Delaware |
0 |
7936111 |
0 |
7936111 |
7936111 |
8.2 % |
14/02/2020 |
Puissance Capital Management LP |
Delaware |
0 |
126865 |
0 |
126865 |
126865 |
0.002 % |
13/02/2020 |
Theodore Wang |
United States America |
0 |
126865 |
0 |
126865 |
126865 |
0.002 % |
13/02/2020 |
Puissance Life Science Opportunities Fund VI |
Cayman Islands |
0 |
126865 |
0 |
126865 |
126865 |
0.002 % |
13/02/2020 |
Puissance Capital Fund LLC |
Delaware |
0 |
126865 |
0 |
126865 |
126865 |
0.002 % |
13/02/2020 |
Puissance Capital Management LLC |
Delaware |
0 |
126865 |
0 |
126865 |
126865 |
0.002 % |
13/02/2020 |
Decheng Capital Management III (Cayman), LLC |
Cayman Islands |
0 |
55555561 |
0 |
55555561 |
55555561 |
5.8 % |
23/12/2019 |
Decheng Capital China Life Sciences USD Fund III, L.P. |
Cayman Islands |
0 |
55555561 |
0 |
55555561 |
55555561 |
5.8 % |
23/12/2019 |
Xiangmin Cui |
United States |
0 |
55555561 |
0 |
55555561 |
55555561 |
5.8 % |
23/12/2019 |
Armistice Capital, LLC |
Delaware |
0 |
6222778 |
0 |
6222778 |
6222778 |
5.7 % |
20/12/2019 |
Armistice Capital Master Fund Ltd. |
Cayman Islands |
0 |
6222778 |
0 |
6222778 |
6222778 |
5.7 % |
20/12/2019 |
Steven Boyd |
United States of America |
0 |
6222778 |
0 |
6222778 |
6222778 |
5.7 % |
20/12/2019 |
Puissance Capital Management LP |
Delaware |
0 |
5009830 |
0 |
5009830 |
5009830 |
9.99 % |
15/03/2019 |
Puissance Capital Management |
Delaware |
0 |
5009830 |
0 |
5009830 |
5009830 |
9.99 % |
15/03/2019 |
Puissance Life Science Opportunities Fund VI |
Cayman Islands |
0 |
5009830 |
0 |
5009830 |
5009830 |
9.99 % |
15/03/2019 |
Puissance Capital Fund |
Delaware |
0 |
5009830 |
0 |
5009830 |
5009830 |
9.99 % |
15/03/2019 |
Theodore Wang |
United States of America |
0 |
5009830 |
0 |
5009830 |
5009830 |
9.99 % |
15/03/2019 |
Caxton Corporation |
Delaware |
0 |
4325000 |
0 |
4325000 |
4325000 |
9 % |
14/02/2019 |
Bruce S. Kovner |
United States |
0 |
4325000 |
0 |
4325000 |
4325000 |
9 % |
14/02/2019 |
CDK Associates, L.L.C. |
Delaware |
0 |
4325000 |
0 |
4325000 |
4325000 |
9 % |
14/02/2019 |
Stonepine Capital Management, LLC |
California |
568450 |
0 |
568450 |
0 |
568450 |
1.2 % |
13/02/2019 |
Timothy P. Lynch |
U.S.A. |
568450 |
0 |
568450 |
0 |
568450 |
1.2 % |
13/02/2019 |
Jon M. Plexico |
U.S.A. |
568450 |
0 |
568450 |
0 |
568450 |
1.2 % |
13/02/2019 |
Stonepine Capital, L.P. |
Delaware |
568450 |
0 |
568450 |
0 |
568450 |
1.2 % |
13/02/2019 |
SANOFI |
Republic France |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2019 |
Stonepine Capital Management, LLC |
California |
2923987 |
0 |
2923987 |
0 |
2923987 |
6.1 % |
25/10/2018 |
Stonepine Capital, L.P. |
Delaware |
2923987 |
0 |
2923987 |
0 |
2923987 |
6.1 % |
25/10/2018 |
Jon M. Plexico |
U.S.A. |
2923987 |
0 |
2923987 |
0 |
2923987 |
6.1 % |
25/10/2018 |
Timothy P. Lynch |
U.S.A. |
2923987 |
0 |
2923987 |
0 |
2923987 |
6.1 % |
25/10/2018 |
Caxton Corporation |
Delaware |
0 |
4870409 |
0 |
4870409 |
4870409 |
9.99 % |
13/03/2018 |
CDK Associates, L.L.C. |
Delaware |
0 |
4870409 |
0 |
4870409 |
4870409 |
9.99 % |
13/03/2018 |
Bruce S. Kovner |
United States |
0 |
4870409 |
0 |
4870409 |
4870409 |
9.99 % |
13/03/2018 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
Deerfield Management Company, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
James E. Flynn |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
SANOFI |
Republic France |
1548751 |
0 |
1548751 |
0 |
1548751 |
5.4 % |
13/02/2018 |
Broadfin Capital, LLC |
Delaware |
0 |
326250 |
0 |
326250 |
326250 |
1.13 % |
13/02/2018 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
326250 |
0 |
326250 |
326250 |
1.13 % |
13/02/2018 |
Kevin Kotler |
United States America |
0 |
326250 |
0 |
326250 |
326250 |
1.13 % |
13/02/2018 |
FMR LLC |
Delaware |
0 |
0 |
305139 |
0 |
305139 |
1.141 % |
11/09/2017 |
Abigail P. Johnson |
United States of America |
0 |
0 |
305139 |
0 |
305139 |
1.141 % |
11/09/2017 |
S Deerfield Mgmt, L.P. |
Delaware |
0 |
1498000 |
0 |
1498000 |
1498000 |
6.13 % |
14/02/2017 |
S Deerfield Management Company, L.P. |
Delaware |
0 |
1498000 |
0 |
1498000 |
1498000 |
6.13 % |
14/02/2017 |
S Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
1498000 |
0 |
1498000 |
1498000 |
6.13 % |
14/02/2017 |
S James E. Flynn |
United States |
0 |
1498000 |
0 |
1498000 |
1498000 |
6.13 % |
14/02/2017 |
Kevin Kotler |
United States America |
0 |
1803523 |
0 |
1803523 |
1803523 |
7.42 % |
10/02/2017 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
1803523 |
0 |
1803523 |
1803523 |
7.42 % |
10/02/2017 |
Broadfin Capital, LLC |
Delaware |
0 |
1803523 |
0 |
1803523 |
1803523 |
7.42 % |
10/02/2017 |
FMR LLC |
Delaware |
0 |
0 |
1500739 |
0 |
1500739 |
6.445 % |
10/08/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
1500739 |
0 |
1500739 |
6.445 % |
10/08/2016 |
(entities only Federated Investors, Inc. |
|
3408360 |
|
3408360 |
|
3408360 |
14.64 % |
08/07/2016 |
Voting Shares Irrevocable Trust |
|
3408360 |
|
3408360 |
|
3408360 |
14.64 % |
08/07/2016 |
John F. Donahue |
|
|
3408360 |
|
3408360 |
3408360 |
14.64 % |
08/07/2016 |
Rhodora J. Donahue |
|
|
3408360 |
|
3408360 |
3408360 |
14.64 % |
08/07/2016 |
J. Christopher Donahue |
|
|
3408360 |
|
3408360 |
3408360 |
14.64 % |
08/07/2016 |
Peter Kolchinsky |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
RA Capital Management, LLC |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Deerfield Management Company, L.P. |
Delaware |
0 |
696281 |
0 |
696281 |
696281 |
5.01 % |
16/02/2016 |
James E. Flynn |
United States |
0 |
696281 |
0 |
696281 |
696281 |
5.01 % |
16/02/2016 |
Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
696281 |
0 |
696281 |
696281 |
5.01 % |
16/02/2016 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
696281 |
0 |
696281 |
696281 |
5.01 % |
16/02/2016 |
Foresite Capital Management II, LLC |
Delaware |
337177 |
5 |
337177 |
0 |
337177 |
2.4 % |
12/02/2016 |
Foresite Capital Fund II, L.P. |
Delaware |
337177 |
5 |
337177 |
0 |
337177 |
2.4 % |
12/02/2016 |
James Tananbaum |
United States |
337177 |
5 |
337177 |
0 |
337177 |
2.4 % |
12/02/2016 |
(entities only Federated Investors, Inc. |
|
1233360 |
|
1233360 |
|
1233360 |
8.87 % |
11/02/2016 |
John F. Donahue |
|
|
1233360 |
|
1233360 |
1233360 |
8.87 % |
11/02/2016 |
Rhodora J. Donahue |
|
|
1233360 |
|
1233360 |
1233360 |
8.87 % |
11/02/2016 |
J. Christopher Donahue |
|
|
1233360 |
|
1233360 |
1233360 |
8.87 % |
11/02/2016 |
Voting Shares Irrevocable Trust |
|
1233360 |
|
1233360 |
|
1233360 |
8.87 % |
11/02/2016 |
GlaxoSmithKline plc |
England and Wales |
545006 |
0 |
545006 |
0 |
545006 |
3.9 % |
09/02/2016 |
Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
775000 |
0 |
775000 |
775000 |
5.6 % |
27/05/2015 |
Kevin Kotler |
United States of America |
0 |
775000 |
0 |
775000 |
775000 |
5.6 % |
27/05/2015 |
Broadfin Capital, LLC |
Delaware |
0 |
775000 |
0 |
775000 |
775000 |
5.6 % |
27/05/2015 |
FMR LLC |
Delaware |
0 |
0 |
1368100 |
0 |
1368100 |
10.374 % |
11/05/2015 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
1368100 |
0 |
1368100 |
10.374 % |
11/05/2015 |
Abigail P. Johnson |
United States of America |
0 |
0 |
1368100 |
0 |
1368100 |
10.374 % |
11/05/2015 |
RA Capital Management, LLC |
Massachusetts |
0 |
840000 |
0 |
840000 |
840000 |
9.9 % |
17/02/2015 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
699720 |
0 |
699720 |
699720 |
8.2 % |
17/02/2015 |
Peter Kolchinsky |
United States |
0 |
840000 |
0 |
840000 |
840000 |
9.9 % |
17/02/2015 |
James E. Flynn |
United States |
0 |
500000 |
0 |
500000 |
500000 |
5.87 % |
17/02/2015 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
500000 |
0 |
500000 |
500000 |
5.87 % |
17/02/2015 |
Deerfield Management Company, L.P. |
Delaware |
0 |
500000 |
0 |
500000 |
500000 |
5.87 % |
17/02/2015 |
Deerfield Partners, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
273000 |
0 |
273000 |
273000 |
3.21 % |
17/02/2015 |
Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
227000 |
0 |
227000 |
227000 |
2.67 % |
17/02/2015 |
James Tananbaum |
United States |
662945 |
5 |
662945 |
0 |
662945 |
7.8 % |
11/02/2015 |
Foresite Capital Fund II, L.P. |
Delaware |
662945 |
5 |
662945 |
0 |
662945 |
7.8 % |
11/02/2015 |
Foresite Capital Management II, LLC |
Delaware |
662945 |
5 |
662945 |
0 |
662945 |
7.8 % |
11/02/2015 |
GlaxoSmithKline plc |
England and Wales |
545009 |
0 |
545009 |
0 |
545009 |
6.2 % |
15/05/2014 |
Alta BioPharma Management II, L.P. |
Delaware |
0 |
1240575 |
0 |
1240575 |
1240575 |
14.7 % |
13/05/2014 |
Farah Champsi |
United States |
0 |
1286311 |
0 |
1286311 |
1286311 |
15.2 % |
13/05/2014 |
Alta Embarcadero BioPharma Management II, L.P. |
California |
45736 |
0 |
45736 |
0 |
45736 |
0.5 % |
13/05/2014 |
Alta BioPharma Partners II, L.P. |
Delaware |
1240575 |
0 |
1240575 |
0 |
1240575 |
14.7 % |
13/05/2014 |
Deerfield Partners, L.P. |
Delaware |
0 |
116717 |
0 |
116717 |
116717 |
1.38 % |
09/05/2014 |
Deerfield Management Company, L.P. |
Delaware |
0 |
760530 |
0 |
760530 |
760530 |
9 % |
09/05/2014 |
Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
222000 |
0 |
222000 |
222000 |
2.63 % |
09/05/2014 |
Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
143813 |
0 |
143813 |
143813 |
1.7 % |
09/05/2014 |
Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
278000 |
0 |
278000 |
278000 |
3.29 % |
09/05/2014 |
Deerfield Mgmt, L.P. |
Delaware |
0 |
760530 |
0 |
760530 |
760530 |
9 % |
09/05/2014 |
James E. Flynn |
United States |
0 |
760530 |
0 |
760530 |
760530 |
9 % |
09/05/2014 |
SANOFI |
Republic France |
1677057 |
0 |
48751 |
1628306 |
1677057 |
19.27 % |
09/05/2014 |
Peter Kolchinsky |
United States |
0 |
840000 |
0 |
840000 |
840000 |
9.9 % |
08/05/2014 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
699720 |
0 |
699720 |
699720 |
8.2 % |
08/05/2014 |
RA Capital Management, LLC |
Massachusetts |
0 |
840000 |
0 |
840000 |
840000 |
9.9 % |
08/05/2014 |