Individual Beneficiary

Name of reporting person Citizenship or organization Sole voting power Shared voting power Sole dispositive power Shared dispositive power Amount beneficially owned Percent of class Accepted date
Avidity Partners Management LP Delaware 0 4040810 0 4040810 4040810 9.9 % 14/11/2024
Michael Gregory United States of America 0 4040810 0 4040810 4040810 9.9 % 14/11/2024
David Witzke United States of America 0 4040810 0 4040810 4040810 9.9 % 14/11/2024
Avidity Private Master Fund I LP Cayman Islands 0 4065207 0 4065207 4065207 9.9 % 14/11/2024
Avidity Master Fund LP Cayman Islands 0 4177203 0 4177203 4177203 9.9 % 14/11/2024
Avidity Capital Partners Delaware 0 4040810 0 4040810 4040810 9.9 % 14/11/2024
Avidity Capital Partners Fund Delaware 0 4040810 0 4040810 4040810 9.9 % 14/11/2024
Avidity Partners Management Delaware 0 4040810 0 4040810 4040810 9.9 % 14/11/2024
J. Christopher Donahue United States 7128250 7128250 7128250 17.22 % 06/11/2024
Ann C. Donahue United States 7128250 7128250 7128250 17.22 % 06/11/2024
Thomas R. Donahue United States 7128250 7128250 7128250 17.22 % 06/11/2024
Voting Shares Irrevocable Trust Pennsylvania 7128250 7128250 7128250 17.22 % 06/11/2024
Federated Hermes, Inc. Pennsylvania 7128250 7128250 7128250 17.22 % 06/11/2024
Federated Hermes, Inc. Pennsylvania 7128250 7128250 7128250 18.83 % 07/10/2024
Voting Shares Irrevocable Trust Pennsylvania 7128250 7128250 7128250 18.83 % 07/10/2024
Thomas R. Donahue United States 7128250 7128250 7128250 18.83 % 07/10/2024
Ann C. Donahue United States 7128250 7128250 7128250 18.83 % 07/10/2024
J. Christopher Donahue United States 7128250 7128250 7128250 18.83 % 07/10/2024
Caxton Corporation Delaware 0 0 0 0 0 0 % 13/02/2024
CDK Associates, L.L.C. Delaware 0 0 0 0 0 0 % 13/02/2024
Bruce S. Kovner United States 0 0 0 0 0 0 % 13/02/2024
Avidity Capital Partners Fund Delaware 0 3968816 0 3968816 3968816 9.9 % 13/02/2024
Avidity Partners Management LP Delaware 0 3968816 0 3968816 3968816 9.9 % 13/02/2024
Avidity Partners Management Delaware 0 3968816 0 3968816 3968816 9.9 % 13/02/2024
Avidity Capital Partners Delaware 0 3968816 0 3968816 3968816 9.9 % 13/02/2024
Avidity Master Fund LP Cayman Islands 0 4105210 0 4105210 4105210 9.9 % 13/02/2024
Avidity Private Master Fund I LP Cayman Islands 0 3993213 0 3993213 3993213 9.9 % 13/02/2024
David Witzke United States of America 0 3968816 0 3968816 3968816 9.9 % 13/02/2024
Michael Gregory United States of America 0 3968816 0 3968816 3968816 9.9 % 13/02/2024
Stonepine Capital, L.P. Delaware 0 1355186 0 1355186 1355186 3.6 % 13/02/2024
Stonepine Capital Management, LLC California 0 1355186 0 1355186 1355186 3.6 % 13/02/2024
Thomas R. Donahue United States 8094700 8094700 8094700 19.99 % 18/01/2024
Ann C. Donahue United States 8094700 8094700 8094700 19.99 % 18/01/2024
Voting Shares Irrevocable Trust Pennsylvania 8094700 8094700 8094700 19.99 % 18/01/2024
Federated Hermes, Inc. Pennsylvania 8094700 8094700 8094700 19.99 % 18/01/2024
J. Christopher Donahue United States 8094700 8094700 8094700 19.99 % 18/01/2024
Kingdon GP, LLC Delaware 0 1982491 0 1982491 1982491 5.33 % 29/11/2023
Mark Kingdon United States of America 0 2237048 0 2237048 2237048 6.02 % 29/11/2023
M. Kingdon Offshore Master Fund L.P. Cayman Islands 0 1982491 0 1982491 1982491 5.33 % 29/11/2023
Kingdon Capital Management, L.L.C. Delaware 0 2237048 0 2237048 2237048 6.02 % 29/11/2023
M. Kingdon Offshore Master Fund L.P. Cayman Islands 0 1982491 0 1982491 1982491 5.33 % 29/11/2023
Kingdon GP, LLC Delaware 0 1982491 0 1982491 1982491 5.33 % 29/11/2023
Kingdon Capital Management, L.L.C. Delaware 0 2237048 0 2237048 2237048 6.02 % 29/11/2023
Mark Kingdon United States of America 0 2237048 0 2237048 2237048 6.02 % 29/11/2023
Stonepine Capital, L.P. Delaware 0 2777877 0 2777877 2777877 7.6 % 09/06/2023
Stonepine Capital, L.P. Delaware 0 2777877 0 2777877 2777877 7.6 % 09/06/2023
Stonepine Capital Management, LLC California 0 2777877 0 2777877 2777877 7.6 % 09/06/2023
Stonepine Capital Management, LLC California 0 2777877 0 2777877 2777877 7.6 % 09/06/2023
Kingdon Capital Management, L.L.C. Delaware 0 1697048 0 1697048 1697048 5.1 % 13/04/2023
Mark Kingdon United States of America 0 1697048 0 1697048 1697048 5.1 % 13/04/2023
Mark Kingdon United States of America 0 1697048 0 1697048 1697048 5.1 % 13/04/2023
Kingdon Capital Management, L.L.C. Delaware 0 1697048 0 1697048 1697048 5.1 % 13/04/2023
AIGH Capital Management, LLC Maryland 1159346 0 1159346 1159346 3.5 % 03/04/2023
Orin Hirschman United States 1159346 1159346 1159346 3.5 % 03/04/2023
AIGH Capital Management, LLC . Maryland 1932046 0 1932046 0 1932046 5.3 % 15/02/2023
Orin Hchman . United States 1932046 0 1932046 0 1932046 5.3 % 15/02/2023
Federated Hermes, Inc. Pennsylvania 6866914 6866914 6866914 19.99 % 01/02/2023
Voting Shares Irrevocable Trust Pennsylvania 6866914 6866914 6866914 19.99 % 01/02/2023
Thomas R. Donahue United States 6866914 6866914 6866914 19.99 % 01/02/2023
J. Christopher Donahue United States 6866914 6866914 6866914 19.99 % 01/02/2023
Joseph Edelman United States of America 0 0 0 0 0 0 % 14/02/2022
Perceptive Life Sciences Master Fund, Ltd. Cayman Islands 0 0 0 0 0 0 % 14/02/2022
Perceptive Advisors LLC Delaware 0 0 0 0 0 0 % 14/02/2022
Caxton Corporation Delaware 0 2210672 0 2210672 2210672 9 % 14/02/2022
CDK Associates, L.L.C. Delaware 0 2210672 0 2210672 2210672 9 % 14/02/2022
Bruce S. Kovner United States 0 2210672 0 2210672 2210672 9 % 14/02/2022
CDK Associates, L.L.C. Delaware 0 2210672 0 2210672 2210672 9 % 14/02/2022
Bruce S. Kovner United States 0 2210672 0 2210672 2210672 9 % 14/02/2022
Caxton Corporation Delaware 0 2210672 0 2210672 2210672 9 % 14/02/2022
J. Christopher Donahue 5915664 5915664 5915664 19.99 % 14/02/2022
Rhodora J. Donahue 5915664 5915664 5915664 19.99 % 14/02/2022
Voting Shares Irrevocable Trust 5915664 5915664 5915664 19.99 % 14/02/2022
Thomas R. Donahue 5915664 5915664 5915664 19.99 % 14/02/2022
(entities only Federated Hermes, Inc. 5915664 5915664 5915664 19.99 % 14/02/2022
Timothy P. Lynch U.S.A. 385650 0 385650 0 385650 1.6 % 11/02/2022
Stonepine Capital, L.P. Delaware 385650 0 385650 0 385650 1.6 % 11/02/2022
Stonepine Capital Management, LLC California 385650 0 385650 0 385650 1.6 % 11/02/2022
Stonepine Capital Management, LLC California 385650 0 385650 0 385650 1.6 % 11/02/2022
Stonepine Capital, L.P. Delaware 385650 0 385650 0 385650 1.6 % 11/02/2022
Jon M. Plexico U.S.A. 385650 0 385650 0 385650 1.6 % 11/02/2022
Timothy P. Lynch U.S.A. 385650 0 385650 0 385650 1.6 % 11/02/2022
Jon M. Plexico U.S.A. 385650 0 385650 0 385650 1.6 % 11/02/2022
(entities only Federated Hermes, Inc. 5449253 5449253 5449253 19.98 % 10/12/2021
Thomas R. Donahue 5449253 5449253 5449253 19.98 % 10/12/2021
Voting Shares Irrevocable Trust 5449253 5449253 5449253 19.98 % 10/12/2021
J. Christopher Donahue 5449253 5449253 5449253 19.98 % 10/12/2021
Rhodora J. Donahue 5449253 5449253 5449253 19.98 % 10/12/2021
Orin Hirschman United States 2048730 2048730 2048730 8.6 % 12/11/2021
AIGH Capital Management, LLC Maryland 2048730 0 2048730 2048730 8.6 % 12/11/2021
Orin Hirschman United States 1345394 1345394 1345394 6.5 % 10/06/2021
AIGH Capital Management, LLC Maryland 1345394 0 1345394 1345394 6.5 % 10/06/2021
(entities only Federated Hermes, Inc. 2129553 2129553 2129553 11.05 % 10/03/2021
Thomas R. Donahue 2129553 2129553 2129553 11.05 % 10/03/2021
Rhodora J. Donahue 2129553 2129553 2129553 11.05 % 10/03/2021
J. Christopher Donahue 2129553 2129553 2129553 11.05 % 10/03/2021
Voting Shares Irrevocable Trust 2129553 2129553 2129553 11.05 % 10/03/2021
Bruce S. Kovner United States 0 1474370 0 1474370 1474370 7.5 % 16/02/2021
Caxton Corporation Delaware 0 1474370 0 1474370 1474370 7.5 % 16/02/2021
CDK Associates, L.L.C. Delaware 0 1474370 0 1474370 1474370 7.5 % 16/02/2021
Bruce S. Kovner United States 0 1474370 0 1474370 1474370 7.5 % 16/02/2021
Caxton Corporation Delaware 0 1474370 0 1474370 1474370 7.5 % 16/02/2021
CDK Associates, L.L.C. Delaware 0 1474370 0 1474370 1474370 7.5 % 16/02/2021
Avidity Capital Partners Fund Delaware 0 1964960 0 1964960 1964960 9.9 % 16/02/2021
Avidity Capital Partners Delaware 0 1964960 0 1964960 1964960 9.9 % 16/02/2021
Avidity Master Fund LP Cayman Islands 0 1979800 0 1979800 1979800 9.9 % 16/02/2021
David Witzke United States of America 0 1964960 0 1964960 1964960 9.9 % 16/02/2021
Michael Gregory United States of America 0 1964960 0 1964960 1964960 9.9 % 16/02/2021
Avidity Partners Management LP Delaware 0 1964960 0 1964960 1964960 9.9 % 16/02/2021
Avidity Partners Management Delaware 0 1964960 0 1964960 1964960 9.9 % 16/02/2021
Jon M. Plexico U.S.A. 1530650 0 1530650 0 1530650 7.7 % 12/02/2021
Timothy P. Lynch U.S.A. 1530650 0 1530650 0 1530650 7.7 % 12/02/2021
Stonepine Capital Management, LLC California 1530650 0 1530650 0 1530650 7.7 % 12/02/2021
Stonepine Capital, L.P. Delaware 1530650 0 1530650 0 1530650 7.7 % 12/02/2021
Stonepine Capital, L.P. Delaware 1530650 0 1530650 0 1530650 7.7 % 12/02/2021
Jon M. Plexico U.S.A. 1530650 0 1530650 0 1530650 7.7 % 12/02/2021
Stonepine Capital Management, LLC California 1530650 0 1530650 0 1530650 7.7 % 12/02/2021
Timothy P. Lynch U.S.A. 1530650 0 1530650 0 1530650 7.7 % 12/02/2021
Voting Shares Irrevocable Trust 2129553 2129553 2129553 19.47 % 12/02/2021
J. Christopher Donahue 2129553 2129553 2129553 19.47 % 12/02/2021
(entities only Federated Hermes, Inc. 2129553 2129553 2129553 19.47 % 12/02/2021
Thomas R. Donahue 2129553 2129553 2129553 19.47 % 12/02/2021
Rhodora J. Donahue 2129553 2129553 2129553 19.47 % 12/02/2021
Puissance Capital Management LP Delaware 0 255718 0 255718 255718 2.34 % 11/02/2021
Puissance Capital Fund LLC Delaware 0 255718 0 255718 255718 2.34 % 11/02/2021
Puissance Life Science Opportunities Fund VI Cayman Islands 0 255718 0 255718 255718 2.34 % 11/02/2021
Theodore Wang United States America 0 255718 0 255718 255718 2.34 % 11/02/2021
Puissance Capital Management LLC Delaware 0 255718 0 255718 255718 2.34 % 11/02/2021
Perceptive Advisors LLC Delaware 0 1300000 0 1300000 1300000 6.8 % 27/01/2021
Joseph Edelman United States of America 0 1300000 0 1300000 1300000 6.8 % 27/01/2021
Perceptive Life Sciences Master Fund, Ltd. Cayman Islands 0 1300000 0 1300000 1300000 6.8 % 27/01/2021
Timothy P. Lynch U.S.A. 1536953 0 1536953 0 1536953 7.7 % 23/12/2020
Stonepine Capital Management, LLC California 1536953 0 1536953 0 1536953 7.7 % 23/12/2020
Stonepine Capital, L.P. Delaware 1536953 0 1536953 0 1536953 7.7 % 23/12/2020
Jon M. Plexico U.S.A. 1536953 0 1536953 0 1536953 7.7 % 23/12/2020
Timothy P. Lynch U.S.A. 1536953 0 1536953 0 1536953 7.7 % 23/12/2020
Stonepine Capital, L.P. Delaware 1536953 0 1536953 0 1536953 7.7 % 23/12/2020
Jon M. Plexico U.S.A. 1536953 0 1536953 0 1536953 7.7 % 23/12/2020
Stonepine Capital Management, LLC California 1536953 0 1536953 0 1536953 7.7 % 23/12/2020
Avidity Capital Partners Fund (GP) LP Delaware 0 1086706 0 1086706 1086706 9.9 % 23/12/2020
David Witzke United States of America 0 1086706 0 1086706 1086706 9.9 % 23/12/2020
Michael Gregory United States of America 0 1086706 0 1086706 1086706 9.9 % 23/12/2020
Avidity Partners Management LP Delaware 0 1086706 0 1086706 1086706 9.9 % 23/12/2020
Avidity Master Fund LP Cayman Islands 0 1097254 0 1097254 1097254 9.9 % 23/12/2020
Avidity Partners Management (GP) LLC Delaware 0 1086706 0 1086706 1086706 9.9 % 23/12/2020
Michael Gregory United States of America 0 1086706 0 1086706 1086706 9.9 % 23/12/2020
David Witzke United States of America 0 1086706 0 1086706 1086706 9.9 % 23/12/2020
Avidity Master Fund LP Cayman Islands 0 1097254 0 1097254 1097254 9.9 % 23/12/2020
Avidity Capital Partners (GP) LLC Delaware 0 1086706 0 1086706 1086706 9.9 % 23/12/2020
Avidity Capital Partners Fund (GP) LP Delaware 0 1086706 0 1086706 1086706 9.9 % 23/12/2020
Avidity Partners Management (GP) LLC Delaware 0 1086706 0 1086706 1086706 9.9 % 23/12/2020
Avidity Capital Partners (GP) LLC Delaware 0 1086706 0 1086706 1086706 9.9 % 23/12/2020
Avidity Partners Management LP Delaware 0 1086706 0 1086706 1086706 9.9 % 23/12/2020
Caxton Corporation Delaware 0 7936111 0 7936111 7936111 8.2 % 14/02/2020
Bruce S. Kovner United States 0 7936111 0 7936111 7936111 8.2 % 14/02/2020
CDK Associates, L.L.C. Delaware 0 7936111 0 7936111 7936111 8.2 % 14/02/2020
Puissance Capital Management LP Delaware 0 126865 0 126865 126865 0.002 % 13/02/2020
Theodore Wang United States America 0 126865 0 126865 126865 0.002 % 13/02/2020
Puissance Life Science Opportunities Fund VI Cayman Islands 0 126865 0 126865 126865 0.002 % 13/02/2020
Puissance Capital Fund LLC Delaware 0 126865 0 126865 126865 0.002 % 13/02/2020
Puissance Capital Management LLC Delaware 0 126865 0 126865 126865 0.002 % 13/02/2020
Decheng Capital Management III (Cayman), LLC Cayman Islands 0 55555561 0 55555561 55555561 5.8 % 23/12/2019
Decheng Capital China Life Sciences USD Fund III, L.P. Cayman Islands 0 55555561 0 55555561 55555561 5.8 % 23/12/2019
Xiangmin Cui United States 0 55555561 0 55555561 55555561 5.8 % 23/12/2019
Armistice Capital, LLC Delaware 0 6222778 0 6222778 6222778 5.7 % 20/12/2019
Armistice Capital Master Fund Ltd. Cayman Islands 0 6222778 0 6222778 6222778 5.7 % 20/12/2019
Steven Boyd United States of America 0 6222778 0 6222778 6222778 5.7 % 20/12/2019
Puissance Capital Management LP Delaware 0 5009830 0 5009830 5009830 9.99 % 15/03/2019
Puissance Capital Management Delaware 0 5009830 0 5009830 5009830 9.99 % 15/03/2019
Puissance Life Science Opportunities Fund VI Cayman Islands 0 5009830 0 5009830 5009830 9.99 % 15/03/2019
Puissance Capital Fund Delaware 0 5009830 0 5009830 5009830 9.99 % 15/03/2019
Theodore Wang United States of America 0 5009830 0 5009830 5009830 9.99 % 15/03/2019
Caxton Corporation Delaware 0 4325000 0 4325000 4325000 9 % 14/02/2019
Bruce S. Kovner United States 0 4325000 0 4325000 4325000 9 % 14/02/2019
CDK Associates, L.L.C. Delaware 0 4325000 0 4325000 4325000 9 % 14/02/2019
Stonepine Capital Management, LLC California 568450 0 568450 0 568450 1.2 % 13/02/2019
Timothy P. Lynch U.S.A. 568450 0 568450 0 568450 1.2 % 13/02/2019
Jon M. Plexico U.S.A. 568450 0 568450 0 568450 1.2 % 13/02/2019
Stonepine Capital, L.P. Delaware 568450 0 568450 0 568450 1.2 % 13/02/2019
SANOFI Republic France 0 0 0 0 0 0 % 12/02/2019
Stonepine Capital Management, LLC California 2923987 0 2923987 0 2923987 6.1 % 25/10/2018
Stonepine Capital, L.P. Delaware 2923987 0 2923987 0 2923987 6.1 % 25/10/2018
Jon M. Plexico U.S.A. 2923987 0 2923987 0 2923987 6.1 % 25/10/2018
Timothy P. Lynch U.S.A. 2923987 0 2923987 0 2923987 6.1 % 25/10/2018
Caxton Corporation Delaware 0 4870409 0 4870409 4870409 9.99 % 13/03/2018
CDK Associates, L.L.C. Delaware 0 4870409 0 4870409 4870409 9.99 % 13/03/2018
Bruce S. Kovner United States 0 4870409 0 4870409 4870409 9.99 % 13/03/2018
Deerfield Mgmt, L.P. Delaware 0 0 0 0 0 0 % 14/02/2018
Deerfield Management Company, L.P. Delaware 0 0 0 0 0 0 % 14/02/2018
Deerfield Special Situations Fund, L.P. Delaware 0 0 0 0 0 0 % 14/02/2018
James E. Flynn United States 0 0 0 0 0 0 % 14/02/2018
SANOFI Republic France 1548751 0 1548751 0 1548751 5.4 % 13/02/2018
Broadfin Capital, LLC Delaware 0 326250 0 326250 326250 1.13 % 13/02/2018
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 326250 0 326250 326250 1.13 % 13/02/2018
Kevin Kotler United States America 0 326250 0 326250 326250 1.13 % 13/02/2018
FMR LLC Delaware 0 0 305139 0 305139 1.141 % 11/09/2017
Abigail P. Johnson United States of America 0 0 305139 0 305139 1.141 % 11/09/2017
S Deerfield Mgmt, L.P. Delaware 0 1498000 0 1498000 1498000 6.13 % 14/02/2017
S Deerfield Management Company, L.P. Delaware 0 1498000 0 1498000 1498000 6.13 % 14/02/2017
S Deerfield Special Situations Fund, L.P. Delaware 0 1498000 0 1498000 1498000 6.13 % 14/02/2017
S James E. Flynn United States 0 1498000 0 1498000 1498000 6.13 % 14/02/2017
Kevin Kotler United States America 0 1803523 0 1803523 1803523 7.42 % 10/02/2017
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 1803523 0 1803523 1803523 7.42 % 10/02/2017
Broadfin Capital, LLC Delaware 0 1803523 0 1803523 1803523 7.42 % 10/02/2017
FMR LLC Delaware 0 0 1500739 0 1500739 6.445 % 10/08/2016
Abigail P. Johnson United States of America 0 0 1500739 0 1500739 6.445 % 10/08/2016
(entities only Federated Investors, Inc. 3408360 3408360 3408360 14.64 % 08/07/2016
Voting Shares Irrevocable Trust 3408360 3408360 3408360 14.64 % 08/07/2016
John F. Donahue 3408360 3408360 3408360 14.64 % 08/07/2016
Rhodora J. Donahue 3408360 3408360 3408360 14.64 % 08/07/2016
J. Christopher Donahue 3408360 3408360 3408360 14.64 % 08/07/2016
Peter Kolchinsky United States 0 0 0 0 0 0 % 16/02/2016
RA Capital Healthcare Fund, L.P. Delaware 0 0 0 0 0 0 % 16/02/2016
RA Capital Management, LLC Massachusetts 0 0 0 0 0 0 % 16/02/2016
Deerfield Management Company, L.P. Delaware 0 696281 0 696281 696281 5.01 % 16/02/2016
James E. Flynn United States 0 696281 0 696281 696281 5.01 % 16/02/2016
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 0 0 0 0 0 % 16/02/2016
Deerfield Special Situations Fund, L.P. Delaware 0 696281 0 696281 696281 5.01 % 16/02/2016
Deerfield Mgmt, L.P. Delaware 0 696281 0 696281 696281 5.01 % 16/02/2016
Foresite Capital Management II, LLC Delaware 337177 5 337177 0 337177 2.4 % 12/02/2016
Foresite Capital Fund II, L.P. Delaware 337177 5 337177 0 337177 2.4 % 12/02/2016
James Tananbaum United States 337177 5 337177 0 337177 2.4 % 12/02/2016
(entities only Federated Investors, Inc. 1233360 1233360 1233360 8.87 % 11/02/2016
John F. Donahue 1233360 1233360 1233360 8.87 % 11/02/2016
Rhodora J. Donahue 1233360 1233360 1233360 8.87 % 11/02/2016
J. Christopher Donahue 1233360 1233360 1233360 8.87 % 11/02/2016
Voting Shares Irrevocable Trust 1233360 1233360 1233360 8.87 % 11/02/2016
GlaxoSmithKline plc England and Wales 545006 0 545006 0 545006 3.9 % 09/02/2016
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 775000 0 775000 775000 5.6 % 27/05/2015
Kevin Kotler United States of America 0 775000 0 775000 775000 5.6 % 27/05/2015
Broadfin Capital, LLC Delaware 0 775000 0 775000 775000 5.6 % 27/05/2015
FMR LLC Delaware 0 0 1368100 0 1368100 10.374 % 11/05/2015
Edward C. Johnson 3d United States of America 0 0 1368100 0 1368100 10.374 % 11/05/2015
Abigail P. Johnson United States of America 0 0 1368100 0 1368100 10.374 % 11/05/2015
RA Capital Management, LLC Massachusetts 0 840000 0 840000 840000 9.9 % 17/02/2015
RA Capital Healthcare Fund, L.P. Delaware 0 699720 0 699720 699720 8.2 % 17/02/2015
Peter Kolchinsky United States 0 840000 0 840000 840000 9.9 % 17/02/2015
James E. Flynn United States 0 500000 0 500000 500000 5.87 % 17/02/2015
Deerfield Mgmt, L.P. Delaware 0 500000 0 500000 500000 5.87 % 17/02/2015
Deerfield Management Company, L.P. Delaware 0 500000 0 500000 500000 5.87 % 17/02/2015
Deerfield Partners, L.P. Delaware 0 0 0 0 0 0 % 17/02/2015
Deerfield Special Situations Fund, L.P. Delaware 0 273000 0 273000 273000 3.21 % 17/02/2015
Deerfield International Master Fund, L.P. British Virgin Islands 0 0 0 0 0 0 % 17/02/2015
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 227000 0 227000 227000 2.67 % 17/02/2015
James Tananbaum United States 662945 5 662945 0 662945 7.8 % 11/02/2015
Foresite Capital Fund II, L.P. Delaware 662945 5 662945 0 662945 7.8 % 11/02/2015
Foresite Capital Management II, LLC Delaware 662945 5 662945 0 662945 7.8 % 11/02/2015
GlaxoSmithKline plc England and Wales 545009 0 545009 0 545009 6.2 % 15/05/2014
Alta BioPharma Management II, L.P. Delaware 0 1240575 0 1240575 1240575 14.7 % 13/05/2014
Farah Champsi United States 0 1286311 0 1286311 1286311 15.2 % 13/05/2014
Alta Embarcadero BioPharma Management II, L.P. California 45736 0 45736 0 45736 0.5 % 13/05/2014
Alta BioPharma Partners II, L.P. Delaware 1240575 0 1240575 0 1240575 14.7 % 13/05/2014
Deerfield Partners, L.P. Delaware 0 116717 0 116717 116717 1.38 % 09/05/2014
Deerfield Management Company, L.P. Delaware 0 760530 0 760530 760530 9 % 09/05/2014
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 222000 0 222000 222000 2.63 % 09/05/2014
Deerfield International Master Fund, L.P. British Virgin Islands 0 143813 0 143813 143813 1.7 % 09/05/2014
Deerfield Special Situations Fund, L.P. Delaware 0 278000 0 278000 278000 3.29 % 09/05/2014
Deerfield Mgmt, L.P. Delaware 0 760530 0 760530 760530 9 % 09/05/2014
James E. Flynn United States 0 760530 0 760530 760530 9 % 09/05/2014
SANOFI Republic France 1677057 0 48751 1628306 1677057 19.27 % 09/05/2014
Peter Kolchinsky United States 0 840000 0 840000 840000 9.9 % 08/05/2014
RA Capital Healthcare Fund, L.P. Delaware 0 699720 0 699720 699720 8.2 % 08/05/2014
RA Capital Management, LLC Massachusetts 0 840000 0 840000 840000 9.9 % 08/05/2014

Senat trading

Bureau Date de la transaction Date de réception Type Amount Commentaire

Senat Divulgation

Représentant Date de la transaction Date de divulgation Type Amount District