BlackRock, Inc. |
Delaware |
9898523 |
0 |
10124431 |
0 |
10124431 |
10.7 % |
07/06/2024 |
Capital International Investors |
Delaware |
4741485 |
0 |
4741485 |
0 |
4741485 |
5.1 % |
09/02/2024 |
Frank M. Sands |
United States |
0 |
1619917 |
0 |
2151378 |
2151378 |
2.5 % |
14/02/2023 |
Sands Capital Management, LLC |
Delaware |
0 |
1619917 |
0 |
2151378 |
2151378 |
2.5 % |
14/02/2023 |
Sands Capital Management, LLC |
Delaware, United States |
|
0 |
5364627 |
0 |
5364627 |
6.16 % |
11/02/2022 |
The Vanguard Group |
Pennsylvania For |
0 |
49273 |
8189990 |
121118 |
8311108 |
9.54 % |
10/02/2022 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2955056 |
0 |
2955056 |
3.391 % |
09/02/2022 |
FMR LLC |
Delaware |
142068 |
0 |
2955056 |
0 |
2955056 |
3.391 % |
09/02/2022 |
BlackRock, Inc. |
Delaware |
5002545 |
0 |
5285234 |
0 |
5285234 |
6.1 % |
01/02/2022 |
Capital Research Global Investors |
Delaware |
3842491 |
0 |
3842491 |
0 |
3842491 |
4.8 % |
10/08/2021 |
Capital Research Global Investors |
Delaware |
3842491 |
0 |
3842491 |
0 |
3842491 |
4.8 % |
10/08/2021 |
Sands Capital Management, LLC |
Delaware, United States |
|
0 |
977131 |
0 |
977131 |
1.24 % |
16/02/2021 |
Sands Capital Management, LLC |
Delaware, United States |
700354 |
0 |
977131 |
0 |
977131 |
1.24 % |
16/02/2021 |
Capital Research Global Investors |
Delaware |
8021170 |
0 |
8024130 |
0 |
8024130 |
10.2 % |
10/02/2021 |
Capital Research Global Investors |
Delaware |
8021170 |
0 |
8024130 |
0 |
8024130 |
10.2 % |
10/02/2021 |
Capital Research Global Investors |
Delaware |
7733923 |
0 |
7736748 |
0 |
7736748 |
9.8 % |
10/02/2021 |
Capital Research Global Investors |
Delaware |
7733923 |
0 |
7736748 |
0 |
7736748 |
9.8 % |
10/02/2021 |
The Vanguard Group |
Pennsylvania For |
0 |
79102 |
7035404 |
181855 |
7217259 |
9.15 % |
10/02/2021 |
BlackRock, Inc. |
Delaware |
4915194 |
0 |
5379215 |
0 |
5379215 |
6.8 % |
01/02/2021 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
749753 |
0 |
3321904 |
0 |
3321904 |
4.4 % |
14/02/2020 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
749753 |
0 |
3321904 |
0 |
3321904 |
4.4 % |
14/02/2020 |
Sands Capital Management, LLC |
Delaware, United States |
|
0 |
4557499 |
0 |
4557499 |
6.1 % |
14/02/2020 |
Sands Capital Management, LLC |
Delaware, United States |
3252168 |
0 |
4557499 |
0 |
4557499 |
6.1 % |
14/02/2020 |
The Vanguard Group |
Pennsylvania |
55559 |
18899 |
6316098 |
68690 |
6384788 |
8.56 % |
12/02/2020 |
BlackRock, Inc. |
Delaware |
4239757 |
0 |
4640285 |
0 |
4640285 |
6.2 % |
10/02/2020 |
FMR LLC |
Delaware |
1292406 |
0 |
8347984 |
0 |
8347984 |
11.173 % |
07/02/2020 |
Abigail P. Johnson |
United States of America |
0 |
0 |
8347984 |
0 |
8347984 |
11.173 % |
07/02/2020 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
656353 |
0 |
4386176 |
0 |
4386176 |
6.1 % |
14/02/2019 |
T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
656353 |
0 |
4386176 |
0 |
4386176 |
6.1 % |
14/02/2019 |
Capital Ventures International |
|
|
|
|
|
925554 |
1.3 % |
14/02/2019 |
G1 Execution Services, LLC |
|
|
|
|
|
925554 |
1.3 % |
14/02/2019 |
Capital Ventures International |
|
|
|
|
|
925554 |
1.3 % |
14/02/2019 |
Susquehanna Advisors Group, Inc. |
|
|
|
|
|
925554 |
1.3 % |
14/02/2019 |
G1 Execution Services, LLC |
|
|
|
|
|
925554 |
1.3 % |
14/02/2019 |
Susquehanna Investment Group |
|
|
|
|
|
925554 |
1.3 % |
14/02/2019 |
Susquehanna Advisors Group, Inc. |
|
|
|
|
|
925554 |
1.3 % |
14/02/2019 |
Susquehanna Investment Group |
|
|
|
|
|
925554 |
1.3 % |
14/02/2019 |
Susquehanna Securities |
|
|
|
|
|
925554 |
1.3 % |
14/02/2019 |
Susquehanna Securities |
|
|
|
|
|
925554 |
1.3 % |
14/02/2019 |
The Vanguard Group |
Pennsylvania |
36222 |
9250 |
5826139 |
39184 |
5865323 |
8.25 % |
13/02/2019 |
BlackRock, Inc. |
Delaware |
4591222 |
0 |
4845231 |
0 |
4845231 |
7.3 % |
06/02/2019 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
973 |
0 |
973 |
973 |
0.1 % |
14/02/2018 |
Steven A. Cohen 3 |
United States |
0 |
780730 |
0 |
780730 |
780730 |
1.2 % |
14/02/2018 |
Point72 Asset Management, L.P. |
Delaware |
0 |
779757 |
0 |
779757 |
779757 |
1.2 % |
14/02/2018 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
779757 |
0 |
779757 |
779757 |
1.2 % |
14/02/2018 |
Jason H. Karp |
USA |
0 |
2027225 |
0 |
2027225 |
2027225 |
3.14 % |
14/02/2018 |
Jason H. Karp |
USA |
0 |
2027225 |
0 |
2027225 |
2027225 |
3.14 % |
14/02/2018 |
Tourbillon Capital Partners LP |
Delaware |
0 |
2027225 |
0 |
2027225 |
2027225 |
3.14 % |
14/02/2018 |
Tourbillon Capital Partners LP |
Delaware |
0 |
2027225 |
0 |
2027225 |
2027225 |
3.14 % |
14/02/2018 |
The Vanguard Group |
Pennsylvania |
106854 |
9450 |
4970119 |
110939 |
5081058 |
7.86 % |
12/02/2018 |
FMR LLC |
Delaware |
1998470 |
0 |
7760905 |
0 |
7760905 |
11.992 % |
12/02/2018 |
Abigail P. Johnson |
United States of America |
0 |
0 |
7760905 |
0 |
7760905 |
11.992 % |
12/02/2018 |
G1 Execution Services, LLC |
|
|
|
|
|
3598961 |
5.6 % |
09/02/2018 |
Susquehanna Advisors Group, Inc. |
|
|
|
|
|
3598961 |
5.6 % |
09/02/2018 |
Susquehanna Securities |
|
|
|
|
|
3598961 |
5.6 % |
09/02/2018 |
Capital Ventures International |
|
|
|
|
|
3598961 |
5.6 % |
09/02/2018 |
Susquehanna Investment Group |
|
|
|
|
|
3598961 |
5.6 % |
09/02/2018 |
Capital Ventures International |
|
|
|
|
|
3598961 |
5.6 % |
09/02/2018 |
Susquehanna Securities |
|
|
|
|
|
3598961 |
5.6 % |
09/02/2018 |
Susquehanna Investment Group |
|
|
|
|
|
3598961 |
5.6 % |
09/02/2018 |
G1 Execution Services, LLC |
|
|
|
|
|
3598961 |
5.6 % |
09/02/2018 |
Susquehanna Advisors Group, Inc. |
|
|
|
|
|
3598961 |
5.6 % |
09/02/2018 |
BlackRock, Inc. |
Delaware |
6161749 |
0 |
6286343 |
0 |
6286343 |
9.7 % |
23/01/2018 |
Capital Ventures International |
|
|
|
|
|
3576970 |
5.4 % |
21/12/2017 |
Capital Ventures International |
|
|
|
|
|
3576970 |
5.4 % |
21/12/2017 |
Susquehanna Securities |
|
|
|
|
|
3576970 |
5.4 % |
21/12/2017 |
Susquehanna Securities |
|
|
|
|
|
3576970 |
5.4 % |
21/12/2017 |
Susquehanna Advisors Group, Inc. |
|
|
|
|
|
3576970 |
5.4 % |
21/12/2017 |
Susquehanna Investment Group |
|
|
|
|
|
3576970 |
5.4 % |
21/12/2017 |
G1 Execution Services, LLC |
|
|
|
|
|
3576970 |
5.4 % |
21/12/2017 |
Susquehanna Advisors Group, Inc. |
|
|
|
|
|
3576970 |
5.4 % |
21/12/2017 |
G1 Execution Services, LLC |
|
|
|
|
|
3576970 |
5.4 % |
21/12/2017 |
Susquehanna Investment Group |
|
|
|
|
|
3576970 |
5.4 % |
21/12/2017 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
5923 |
0 |
5923 |
5923 |
0.1 % |
23/02/2017 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
2819180 |
0 |
2819180 |
2819180 |
5.2 % |
23/02/2017 |
Steven A. Cohen |
United States |
0 |
2825103 |
0 |
2825103 |
2825103 |
5.2 % |
23/02/2017 |
Point72 Asset Management, L.P. |
Delaware |
0 |
2819180 |
0 |
2819180 |
2819180 |
5.2 % |
23/02/2017 |
Point72 Asset Management, L.P. |
Delaware |
0 |
2819180 |
0 |
2819180 |
2819180 |
5.2 % |
23/02/2017 |
Steven A. Cohen |
United States |
0 |
2825103 |
0 |
2825103 |
2825103 |
5.2 % |
23/02/2017 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
5923 |
0 |
5923 |
5923 |
0.1 % |
23/02/2017 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
2819180 |
0 |
2819180 |
2819180 |
5.2 % |
23/02/2017 |
Tourbillon Capital Partners LP |
Delaware |
0 |
3096756 |
0 |
3096756 |
3096756 |
5.67 % |
14/02/2017 |
Jason H. Karp |
USA |
0 |
3096756 |
0 |
3096756 |
3096756 |
5.67 % |
14/02/2017 |
Tourbillon Capital Partners LP |
Delaware |
0 |
3096756 |
0 |
3096756 |
3096756 |
5.67 % |
14/02/2017 |
Jason H. Karp |
USA |
0 |
3096756 |
0 |
3096756 |
3096756 |
5.67 % |
14/02/2017 |
The Vanguard Group |
Pennsylvania |
99007 |
8450 |
3814612 |
104908 |
3919520 |
7.17 % |
13/02/2017 |
BlackRock, Inc. |
Delaware |
5199211 |
0 |
5310944 |
0 |
5310944 |
9.7 % |
26/01/2017 |
Sabby Management, LLC |
Delaware USA |
0 |
2075887 |
0 |
2075887 |
2075887 |
3.8 % |
10/01/2017 |
Hal Mintz |
USA |
0 |
2075887 |
0 |
2075887 |
2075887 |
3.8 % |
10/01/2017 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
2075887 |
0 |
2075887 |
2075887 |
3.8 % |
10/01/2017 |
Sabby Management, LLC |
Delaware USA |
0 |
2075887 |
0 |
2075887 |
2075887 |
3.8 % |
10/01/2017 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
2075887 |
0 |
2075887 |
2075887 |
3.8 % |
10/01/2017 |
Hal Mintz |
USA |
0 |
2075887 |
0 |
2075887 |
2075887 |
3.8 % |
10/01/2017 |
Jason H. Karp |
USA |
0 |
3332300 |
0 |
3332300 |
3332300 |
6.2 % |
28/10/2016 |
Tourbillon Capital Partners LP |
Delaware |
0 |
3332300 |
0 |
3332300 |
3332300 |
6.2 % |
28/10/2016 |
Tourbillon Capital Partners LP |
Delaware |
0 |
3332300 |
0 |
3332300 |
3332300 |
6.2 % |
28/10/2016 |
Jason H. Karp |
USA |
0 |
3332300 |
0 |
3332300 |
3332300 |
6.2 % |
28/10/2016 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
2357878 |
0 |
2357878 |
2357878 |
5.15 % |
06/05/2016 |
Hal Mintz |
USA |
0 |
2357878 |
0 |
2357878 |
2357878 |
5.15 % |
06/05/2016 |
Sabby Management, LLC |
Delaware USA |
0 |
2357878 |
0 |
2357878 |
2357878 |
5.15 % |
06/05/2016 |
Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
2357878 |
0 |
2357878 |
2357878 |
5.15 % |
06/05/2016 |
Hal Mintz |
USA |
0 |
2357878 |
0 |
2357878 |
2357878 |
5.15 % |
06/05/2016 |
Sabby Management, LLC |
Delaware USA |
0 |
2357878 |
0 |
2357878 |
2357878 |
5.15 % |
06/05/2016 |
Perceptive Advisors LLC |
Delaware, United States of America |
0 |
2240928 |
0 |
|
2240928 |
4.95 % |
16/02/2016 |
Perceptive Advisors LLC |
Delaware, United States of America |
0 |
2240928 |
0 |
|
2240928 |
4.95 % |
16/02/2016 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
2755900 |
0 |
2755900 |
2755900 |
6.1 % |
16/02/2016 |
Point72 Asset Management, L.P. |
Delaware |
0 |
2755900 |
0 |
2755900 |
2755900 |
6.1 % |
16/02/2016 |
Steven A. Cohen |
United States |
0 |
2760794 |
0 |
2760794 |
2760794 |
6.1 % |
16/02/2016 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
4894 |
0 |
4894 |
4894 |
0.1 % |
16/02/2016 |
FMR LLC |
Delaware |
3890 |
0 |
2372287 |
0 |
2372287 |
5.24 % |
12/02/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2372287 |
0 |
2372287 |
5.24 % |
12/02/2016 |
FMR LLC |
Delaware |
3890 |
0 |
2372287 |
0 |
2372287 |
5.24 % |
12/02/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2372287 |
0 |
2372287 |
5.24 % |
12/02/2016 |
The Vanguard Group |
Pennsylvania |
96539 |
|
2745990 |
94139 |
2840129 |
6.27 % |
10/02/2016 |
BlackRock, Inc. |
Delaware |
2797216 |
0 |
2891861 |
0 |
2891861 |
6.4 % |
27/01/2016 |
Columbia Wanger Asset Management, LLC |
Delaware |
|
|
|
|
0 |
0 % |
20/01/2016 |
Columbia Wanger Asset Management, LLC |
Delaware |
|
|
|
|
0 |
0 % |
20/01/2016 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
2193600 |
0 |
2193600 |
2193600 |
5.3 % |
01/05/2015 |
Point72 Asset Management, L.P. |
Delaware |
0 |
2193600 |
0 |
2193600 |
2193600 |
5.3 % |
01/05/2015 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
2193600 |
0 |
2193600 |
2193600 |
5.3 % |
01/05/2015 |
Point72 Asset Management, L.P. |
Delaware |
0 |
2193600 |
0 |
2193600 |
2193600 |
5.3 % |
01/05/2015 |
Steven A. Cohen |
United States |
0 |
2193600 |
0 |
2193600 |
2193600 |
5.3 % |
01/05/2015 |
Steven A. Cohen |
United States |
0 |
2193600 |
0 |
2193600 |
2193600 |
5.3 % |
01/05/2015 |
Richard J. Barry |
UNITED STATES |
3165014 |
0 |
3165014 |
0 |
3165014 |
7.66 % |
19/02/2015 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
1826500 |
0 |
1826500 |
1826500 |
4.4 % |
17/02/2015 |
Point72 Asset Management, L.P. |
Delaware |
0 |
1826500 |
0 |
1826500 |
1826500 |
4.4 % |
17/02/2015 |
Steven A. Cohen |
United States |
0 |
1826500 |
0 |
1826500 |
1826500 |
4.4 % |
17/02/2015 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
Perceptive Advisors LLC |
Delaware, United States of America |
0 |
2812352 |
0 |
2812352 |
2812352 |
6.81 % |
17/02/2015 |
Perceptive Advisors LLC |
Delaware, United States of America |
0 |
2812352 |
0 |
2812352 |
2812352 |
6.81 % |
17/02/2015 |
The Vanguard Group |
Pennsylvania |
51542 |
|
2242672 |
48042 |
2290714 |
5.54 % |
10/02/2015 |
BlackRock, Inc. |
Delaware |
3110909 |
0 |
3202261 |
0 |
3202261 |
7.8 % |
26/01/2015 |
Point72 Asset Management, L.P. |
Delaware |
0 |
2082300 |
0 |
2082300 |
2082300 |
5.2 % |
30/04/2014 |
Steven A. Cohen |
United States |
0 |
2083100 |
0 |
2083100 |
2083100 |
5.2 % |
30/04/2014 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
800 |
0 |
800 |
800 |
0.1 % |
30/04/2014 |
Steven A. Cohen |
United States |
0 |
2083100 |
0 |
2083100 |
2083100 |
5.2 % |
30/04/2014 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
800 |
0 |
800 |
800 |
0.1 % |
30/04/2014 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
2082300 |
0 |
2082300 |
2082300 |
5.2 % |
30/04/2014 |
Point72 Asset Management, L.P. |
Delaware |
0 |
2082300 |
0 |
2082300 |
2082300 |
5.2 % |
30/04/2014 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
2082300 |
0 |
2082300 |
2082300 |
5.2 % |
30/04/2014 |
The Vanguard Group |
Pennsylvania |
51265 |
|
2011773 |
49565 |
2061338 |
5.48 % |
11/02/2014 |
Columbia Acorn Fund |
Massachusetts |
2050000 |
0 |
2050000 |
0 |
2050000 |
5.4 % |
06/02/2014 |
Columbia Acorn Fund |
Massachusetts |
2050000 |
0 |
2050000 |
0 |
2050000 |
5.4 % |
06/02/2014 |
Columbia Wanger Asset Management, LLC |
Delaware |
2538000 |
0 |
2635000 |
0 |
2635000 |
7 % |
06/02/2014 |
Columbia Wanger Asset Management, LLC |
Delaware |
2538000 |
0 |
2635000 |
0 |
2635000 |
7 % |
06/02/2014 |
BlackRock, Inc. |
Delaware |
2401548 |
0 |
2506641 |
0 |
2506641 |
6.7 % |
30/01/2014 |
Sabby Healthcare Volatility Master Fund, Ltd. |
Cayman Islands |
0 |
781342 |
0 |
781342 |
781342 |
2.08 % |
16/01/2014 |
Hal Mintz |
USA |
0 |
781342 |
0 |
781342 |
781342 |
2.08 % |
16/01/2014 |
Sabby Management, LLC |
Delaware USA |
0 |
781342 |
0 |
781342 |
781342 |
2.08 % |
16/01/2014 |
Hal Mintz |
USA |
0 |
781342 |
0 |
781342 |
781342 |
2.08 % |
16/01/2014 |
Sabby Healthcare Volatility Master Fund, Ltd. |
Cayman Islands |
0 |
781342 |
0 |
781342 |
781342 |
2.08 % |
16/01/2014 |
Sabby Management, LLC |
Delaware USA |
0 |
781342 |
0 |
781342 |
781342 |
2.08 % |
16/01/2014 |
Hal Mintz |
USA |
0 |
1674193 |
0 |
1674193 |
1674193 |
5.26 % |
24/04/2013 |
Sabby Healthcare Volatility Master Fund, Ltd. |
Cayman Islands |
0 |
1674193 |
0 |
1674193 |
1674193 |
5.26 % |
24/04/2013 |
Sabby Management, LLC |
Delaware USA |
0 |
1674193 |
0 |
1674193 |
1674193 |
5.26 % |
24/04/2013 |
Hal Mintz |
USA |
0 |
1674193 |
0 |
1674193 |
1674193 |
5.26 % |
24/04/2013 |
Sabby Healthcare Volatility Master Fund, Ltd. |
Cayman Islands |
0 |
1674193 |
0 |
1674193 |
1674193 |
5.26 % |
24/04/2013 |
Sabby Management, LLC |
Delaware USA |
0 |
1674193 |
0 |
1674193 |
1674193 |
5.26 % |
24/04/2013 |
Richard J. Barry |
UNITED STATES |
1498556 |
0 |
1498556 |
0 |
1498556 |
5.3 % |
19/11/2012 |
BlackRock, Inc. |
Delaware |
3606976 |
0 |
3606976 |
0 |
3606976 |
2.66 % |
10/07/2012 |
George W. Haywood |
U.S.A |
7146499 |
700000 |
7146499 |
700000 |
7846499 |
6.9 % |
14/02/2011 |
BlackRock, Inc. |
Delaware |
6945871 |
0 |
6945871 |
0 |
6945871 |
6.18 % |
02/02/2011 |
Emerging Markets Master Fund Limited |
Cayman Islands |
5589175 |
0 |
5589175 |
0 |
5589175 |
4.9 % |
25/01/2011 |
Dobrich |
USA |
1159464 |
5589175 |
1159464 |
5589175 |
6748639 |
6 % |
25/01/2011 |
O’Driscoll |
USA |
577523 |
5589175 |
577523 |
5589175 |
6166698 |
5.5 % |
25/01/2011 |
Egan |
Ireland |
1150000 |
5589175 |
1150000 |
5589175 |
6739175 |
6 % |
25/01/2011 |
Asset Management, LLC |
Delaware |
5589175 |
0 |
5589175 |
0 |
5589175 |
4.9 % |
25/01/2011 |
George W. Haywood |
U.S.A |
7545000 |
960000 |
7545000 |
960000 |
8505000 |
13.1 % |
14/02/2008 |