Sierra Oncology, Inc. SRRA
Trading inactive
| Name of reporting person | Citizenship or organization | Sole voting power | Shared voting power | Sole dispositive power | Shared dispositive power | Amount beneficially owned | Percent of class | Accepted date |
|---|---|---|---|---|---|---|---|---|
| Asset Management Exchange Master ICAV | Ireland | 0 | 0 | 0 | 0 | 0 | 0 % | 10/02/2023 |
| Asset Management Exchange Master ICAV | Ireland | 0 | 0 | 0 | 0 | 0 | 0 % | 10/02/2023 |
| Vivo Ventures VII, LLC | Delaware | 0 | 0 | 0 | 0 | 0 % | 05/07/2022 | |
| Vivo Opportunity, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 05/07/2022 |
| Vivo Capital IX, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 05/07/2022 |
| Vivo Capital IX, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 05/07/2022 |
| Vivo Ventures VII, LLC | Delaware | 0 | 0 | 0 | 0 | 0 % | 05/07/2022 | |
| Vivo Opportunity, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 05/07/2022 |
| Asset Management Exchange Master ICAV | Ireland | 1266927 | 0 | 1266927 | 0 | 0 | 5.3 % | 22/04/2022 |
| Asset Management Exchange Master ICAV | Ireland | 1266927 | 0 | 1266927 | 0 | 0 | 5.3 % | 22/04/2022 |
| Nathan Every | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.2 % | 29/03/2022 |
| Alan Frazier | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.2 % | 29/03/2022 |
| Patrick J. Heron | United States Citizen | 0 | 2366853 | 0 | 2366853 | 2366853 | 10 % | 29/03/2022 |
| James N. Topper | United States Citizen | 0 | 2366853 | 0 | 2366853 | 2366853 | 10 % | 29/03/2022 |
| Frazier Healthcare VI, L.P. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.2 % | 29/03/2022 |
| FHM Life Sciences VIII, L.L.C. | Delaware | 0 | 522663 | 0 | 522663 | 522663 | 2.2 % | 29/03/2022 |
| FHM Life Sciences VIII, L.P. | Delaware | 0 | 522663 | 0 | 522663 | 522663 | 2.2 % | 29/03/2022 |
| James N. Topper | United States Citizen | 0 | 2366853 | 0 | 2366853 | 2366853 | 10 % | 29/03/2022 |
| FHMLSP, L.L.C. | Delaware | 0 | 1789535 | 0 | 1789535 | 1789535 | 7.6 % | 29/03/2022 |
| FHMLSP, L.P. | Delaware | 0 | 1789535 | 0 | 1789535 | 1789535 | 7.6 % | 29/03/2022 |
| Frazier Life Sciences Public Fund, L.P. | Delaware | 0 | 1789535 | 0 | 1789535 | 1789535 | 7.6 % | 29/03/2022 |
| FHM VI, L.L.C. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.2 % | 29/03/2022 |
| FHM VI, L.P. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.2 % | 29/03/2022 |
| James Brush | United States Citizen | 0 | 1789535 | 0 | 1789535 | 1789535 | 7.6 % | 29/03/2022 |
| FHMLSP, L.L.C. | Delaware | 0 | 1789535 | 0 | 1789535 | 1789535 | 7.6 % | 29/03/2022 |
| FHMLSP, L.P. | Delaware | 0 | 1789535 | 0 | 1789535 | 1789535 | 7.6 % | 29/03/2022 |
| Frazier Life Sciences Public Fund, L.P. | Delaware | 0 | 1789535 | 0 | 1789535 | 1789535 | 7.6 % | 29/03/2022 |
| FHM VI, L.P. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.2 % | 29/03/2022 |
| Frazier Healthcare VI, L.P. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.2 % | 29/03/2022 |
| FHM Life Sciences VIII, L.L.C. | Delaware | 0 | 522663 | 0 | 522663 | 522663 | 2.2 % | 29/03/2022 |
| FHM Life Sciences VIII, L.P. | Delaware | 0 | 522663 | 0 | 522663 | 522663 | 2.2 % | 29/03/2022 |
| Frazier Life Sciences VIII, L.P. | Delaware | 0 | 522663 | 0 | 522663 | 522663 | 2.2 % | 29/03/2022 |
| Albert Cha | United States Citizen | 0 | 1789535 | 0 | 1789535 | 1789535 | 7.6 % | 29/03/2022 |
| Nader Naini | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.2 % | 29/03/2022 |
| FHM VI, L.L.C. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.2 % | 29/03/2022 |
| James Brush | United States Citizen | 0 | 1789535 | 0 | 1789535 | 1789535 | 7.6 % | 29/03/2022 |
| Albert Cha | United States Citizen | 0 | 1789535 | 0 | 1789535 | 1789535 | 7.6 % | 29/03/2022 |
| Nathan Every | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.2 % | 29/03/2022 |
| Nader Naini | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.2 % | 29/03/2022 |
| Frazier Life Sciences VIII, L.P. | Delaware | 0 | 522663 | 0 | 522663 | 522663 | 2.2 % | 29/03/2022 |
| Alan Frazier | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.2 % | 29/03/2022 |
| Patrick J. Heron | United States Citizen | 0 | 2366853 | 0 | 2366853 | 2366853 | 10 % | 29/03/2022 |
| Rock Springs Capital LLC | Delaware | 0 | 1184793 | 0 | 1184793 | 1184793 | 7.87 % | 14/02/2022 |
| Rock Springs Capital Master Fund LP | Cayman Islands | 0 | 1106500 | 0 | 1106500 | 1106500 | 7.35 % | 14/02/2022 |
| Rock Springs Capital Management LP | Delaware | 0 | 1184793 | 0 | 1184793 | 1184793 | 7.87 % | 14/02/2022 |
| Venrock Healthcare Capital Partners II, L.P. | Delaware | 0 | 984746 | 0 | 984746 | 984746 | 6.1 % | 14/02/2022 |
| Shah, Nimish | United States | 0 | 984746 | 0 | 984746 | 984746 | 6.1 % | 14/02/2022 |
| Koh, Bong | United States | 0 | 984746 | 0 | 984746 | 984746 | 6.1 % | 14/02/2022 |
| Venrock Healthcare Capital Partners III, L.P. | Delaware | 0 | 984746 | 0 | 984746 | 984746 | 6.1 % | 14/02/2022 |
| VHCP Management III, LLC | Delaware | 0 | 984746 | 0 | 984746 | 984746 | 6.1 % | 14/02/2022 |
| VHCP Management II, LLC | Delaware | 0 | 984746 | 0 | 984746 | 984746 | 6.1 % | 14/02/2022 |
| VHCP CoInvestment Holdings III, LLC | Delaware | 0 | 984746 | 0 | 984746 | 984746 | 6.1 % | 14/02/2022 |
| VHCP CoInvestment Holdings II, LLC | Delaware | 0 | 984746 | 0 | 984746 | 984746 | 6.1 % | 14/02/2022 |
| Caxton Corporation | Delaware | 0 | 1119322 | 0 | 1119322 | 1119322 | 7 % | 14/02/2022 |
| CDK Associates, L.L.C. | Delaware | 0 | 1052157 | 0 | 1052157 | 1052157 | 6.6 % | 14/02/2022 |
| Bruce S. Kovner | United States | 0 | 1119322 | 0 | 1119322 | 1119322 | 7 % | 14/02/2022 |
| Bruce S. Kovner | United States | 0 | 1119322 | 0 | 1119322 | 1119322 | 7 % | 14/02/2022 |
| CDK Associates, L.L.C. | Delaware | 0 | 1052157 | 0 | 1052157 | 1052157 | 6.6 % | 14/02/2022 |
| Caxton Corporation | Delaware | 0 | 1119322 | 0 | 1119322 | 1119322 | 7 % | 14/02/2022 |
| FHMLSP, L.P. | Delaware | 0 | 1062058 | 0 | 1062058 | 1062058 | 7.1 % | 28/01/2022 |
| James Brush | United States Citizen | 0 | 1062058 | 0 | 1062058 | 1062058 | 7.1 % | 28/01/2022 |
| Albert Cha | United States Citizen | 0 | 1062058 | 0 | 1062058 | 1062058 | 7.1 % | 28/01/2022 |
| Nathan Every | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 28/01/2022 |
| Nader Naini | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 28/01/2022 |
| Alan Frazier | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 28/01/2022 |
| Patrick J. Heron | United States Citizen | 0 | 1264861 | 0 | 1264861 | 1264861 | 8.4 % | 28/01/2022 |
| James N. Topper | United States Citizen | 0 | 1264861 | 0 | 1264861 | 1264861 | 8.4 % | 28/01/2022 |
| FHMLSP, L.L.C. | Delaware | 0 | 1062058 | 0 | 1062058 | 1062058 | 7.1 % | 28/01/2022 |
| FHMLSP, L.P. | Delaware | 0 | 1062058 | 0 | 1062058 | 1062058 | 7.1 % | 28/01/2022 |
| Frazier Life Sciences Public Fund, L.P. | Delaware | 0 | 1062058 | 0 | 1062058 | 1062058 | 7.1 % | 28/01/2022 |
| FHM VI, L.L.C. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 28/01/2022 |
| FHM VI, L.P. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 28/01/2022 |
| FHM Life Sciences VIII, L.P. | Delaware | 0 | 148148 | 0 | 148148 | 148148 | 1 % | 28/01/2022 |
| Frazier Life Sciences VIII, L.P. | Delaware | 0 | 148148 | 0 | 148148 | 148148 | 1 % | 28/01/2022 |
| Frazier Healthcare VI, L.P. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 28/01/2022 |
| FHM Life Sciences VIII, L.L.C. | Delaware | 0 | 148148 | 0 | 148148 | 148148 | 1 % | 28/01/2022 |
| Frazier Life Sciences VIII, L.P. | Delaware | 0 | 148148 | 0 | 148148 | 148148 | 1 % | 28/01/2022 |
| FHM Life Sciences VIII, L.P. | Delaware | 0 | 148148 | 0 | 148148 | 148148 | 1 % | 28/01/2022 |
| FHM Life Sciences VIII, L.L.C. | Delaware | 0 | 148148 | 0 | 148148 | 148148 | 1 % | 28/01/2022 |
| Frazier Healthcare VI, L.P. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 28/01/2022 |
| FHM VI, L.P. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 28/01/2022 |
| FHM VI, L.L.C. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 28/01/2022 |
| Frazier Life Sciences Public Fund, L.P. | Delaware | 0 | 1062058 | 0 | 1062058 | 1062058 | 7.1 % | 28/01/2022 |
| FHMLSP, L.L.C. | Delaware | 0 | 1062058 | 0 | 1062058 | 1062058 | 7.1 % | 28/01/2022 |
| James N. Topper | United States Citizen | 0 | 1264861 | 0 | 1264861 | 1264861 | 8.4 % | 28/01/2022 |
| Patrick J. Heron | United States Citizen | 0 | 1264861 | 0 | 1264861 | 1264861 | 8.4 % | 28/01/2022 |
| Alan Frazier | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 28/01/2022 |
| Nader Naini | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 28/01/2022 |
| Nathan Every | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 28/01/2022 |
| Albert Cha | United States Citizen | 0 | 1062058 | 0 | 1062058 | 1062058 | 7.1 % | 28/01/2022 |
| James Brush | United States Citizen | 0 | 1062058 | 0 | 1062058 | 1062058 | 7.1 % | 28/01/2022 |
| Vivo Capital IX, LLC | Delaware | 431947 | 0 | 431947 | 0 | 431947 | 3.4 % | 05/11/2021 |
| Vivo Ventures VII, LLC | Delaware | 161712 | 0 | 161712 | 0 | 161712 | 1.3 % | 05/11/2021 |
| Vivo Opportunity, LLC | Delaware | 1935853 | 0 | 1935853 | 0 | 1935853 | 14.8 % | 05/11/2021 |
| Vivo Ventures VII, LLC | Delaware | 161712 | 0 | 161712 | 0 | 161712 | 1.3 % | 05/11/2021 |
| Vivo Opportunity, LLC | Delaware | 1935853 | 0 | 1935853 | 0 | 1935853 | 14.8 % | 05/11/2021 |
| Vivo Capital IX, LLC | Delaware | 431947 | 0 | 431947 | 0 | 431947 | 3.4 % | 05/11/2021 |
| FHM VI, L.L.C. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 16/08/2021 |
| Frazier Life Sciences Public Fund L.P. | Delaware | 0 | 601864 | 0 | 601864 | 601864 | 4.8 % | 16/08/2021 |
| FHMLSP, L.P. | Delaware | 0 | 601864 | 0 | 601864 | 601864 | 4.8 % | 16/08/2021 |
| FHMLSP, L.L.C. | Delaware | 0 | 601864 | 0 | 601864 | 601864 | 4.8 % | 16/08/2021 |
| James N. Topper | United States Citizen | 0 | 804667 | 0 | 804667 | 804667 | 6.4 % | 16/08/2021 |
| Patrick J. Heron | United States Citizen | 0 | 804667 | 0 | 804667 | 804667 | 9.5 % | 16/08/2021 |
| James Brush | United States Citizen | 0 | 601864 | 0 | 601864 | 601864 | 4.8 % | 16/08/2021 |
| Nathan Every | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 16/08/2021 |
| Albert Cha | United States Citizen | 0 | 601864 | 0 | 601864 | 601864 | 4.8 % | 16/08/2021 |
| James Brush | United States Citizen | 0 | 601864 | 0 | 601864 | 601864 | 4.8 % | 16/08/2021 |
| Alan Frazier | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 16/08/2021 |
| Nader Naini | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 16/08/2021 |
| Frazier Life Sciences VIII, L.P. | Delaware | 0 | 148148 | 0 | 148148 | 148148 | 1.2 % | 16/08/2021 |
| FHM Life Sciences VIII, L.P. | Delaware | 0 | 148148 | 0 | 148148 | 148148 | 1.2 % | 16/08/2021 |
| FHM Life Sciences VIII, L.L.C. | Delaware | 0 | 148148 | 0 | 148148 | 148148 | 1.2 % | 16/08/2021 |
| Frazier Healthcare VI, L.P. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 16/08/2021 |
| FHM VI, L.P. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 16/08/2021 |
| Nader Naini | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 16/08/2021 |
| Nathan Every | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 16/08/2021 |
| Albert Cha | United States Citizen | 0 | 601864 | 0 | 601864 | 601864 | 4.8 % | 16/08/2021 |
| Frazier Life Sciences VIII, L.P. | Delaware | 0 | 148148 | 0 | 148148 | 148148 | 1.2 % | 16/08/2021 |
| FHM Life Sciences VIII, L.P. | Delaware | 0 | 148148 | 0 | 148148 | 148148 | 1.2 % | 16/08/2021 |
| FHM Life Sciences VIII, L.L.C. | Delaware | 0 | 148148 | 0 | 148148 | 148148 | 1.2 % | 16/08/2021 |
| Frazier Healthcare VI, L.P. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 16/08/2021 |
| FHM VI, L.P. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 16/08/2021 |
| FHM VI, L.L.C. | Delaware | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 16/08/2021 |
| Frazier Life Sciences Public Fund L.P. | Delaware | 0 | 601864 | 0 | 601864 | 601864 | 4.8 % | 16/08/2021 |
| FHMLSP, L.P. | Delaware | 0 | 601864 | 0 | 601864 | 601864 | 4.8 % | 16/08/2021 |
| FHMLSP, L.L.C. | Delaware | 0 | 601864 | 0 | 601864 | 601864 | 4.8 % | 16/08/2021 |
| James N. Topper | United States Citizen | 0 | 804667 | 0 | 804667 | 804667 | 6.4 % | 16/08/2021 |
| Patrick J. Heron | United States Citizen | 0 | 804667 | 0 | 804667 | 804667 | 9.5 % | 16/08/2021 |
| Alan Frazier | United States Citizen | 0 | 54655 | 0 | 54655 | 54655 | 0.4 % | 16/08/2021 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 794140 | 0 | 794140 | 794140 | 6.83 % | 01/04/2021 |
| Robert Atchinson | United States | 0 | 794140 | 0 | 794140 | 794140 | 6.83 % | 01/04/2021 |
| Phillip Gross | United States | 0 | 794140 | 0 | 794140 | 794140 | 6.83 % | 01/04/2021 |
| Adage Capital Partners, L.P. | Delaware | 0 | 794140 | 0 | 794140 | 794140 | 6.83 % | 01/04/2021 |
| Adage Capital Partners, L.P. | Delaware | 0 | 794140 | 0 | 794140 | 794140 | 6.83 % | 01/04/2021 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 794140 | 0 | 794140 | 794140 | 6.83 % | 01/04/2021 |
| Robert Atchinson | United States | 0 | 794140 | 0 | 794140 | 794140 | 6.83 % | 01/04/2021 |
| Phillip Gross | United States | 0 | 794140 | 0 | 794140 | 794140 | 6.83 % | 01/04/2021 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 794140 | 0 | 794140 | 794140 | 6.83 % | 01/04/2021 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 794140 | 0 | 794140 | 794140 | 6.83 % | 01/04/2021 |
| Bruce S. Kovner | United States | 0 | 1142361 | 0 | 1142361 | 1142361 | 9.9 % | 16/02/2021 |
| CDK Associates, L.L.C. | Delaware | 0 | 1142361 | 0 | 1142361 | 1142361 | 9.9 % | 16/02/2021 |
| Caxton Corporation | Delaware | 0 | 1142361 | 0 | 1142361 | 1142361 | 9.9 % | 16/02/2021 |
| Bruce S. Kovner | United States | 0 | 1142361 | 0 | 1142361 | 1142361 | 9.9 % | 16/02/2021 |
| Caxton Corporation | Delaware | 0 | 1142361 | 0 | 1142361 | 1142361 | 9.9 % | 16/02/2021 |
| CDK Associates, L.L.C. | Delaware | 0 | 1142361 | 0 | 1142361 | 1142361 | 9.9 % | 16/02/2021 |
| Rock Springs Capital Master Fund LP | Cayman Islands | 0 | 550000 | 0 | 550000 | 550000 | 4.98 % | 16/02/2021 |
| Rock Springs Capital LLC | Delaware | 0 | 567358 | 0 | 567358 | 0 | 5.14 % | 16/02/2021 |
| Rock Springs Capital Master Fund LP | Cayman Islands | 0 | 550000 | 0 | 550000 | 0 | 4.98 % | 16/02/2021 |
| Rock Springs Capital Management LP | Delaware | 0 | 567358 | 0 | 567358 | 0 | 5.14 % | 16/02/2021 |
| Rock Springs Capital Management LP | Delaware | 0 | 567358 | 0 | 567358 | 567358 | 5.14 % | 16/02/2021 |
| Rock Springs Capital LLC | Delaware | 0 | 567358 | 0 | 567358 | 567358 | 5.14 % | 16/02/2021 |
| NATHANIEL AUGUST | UNITED STATES OF AMERICA | 0 | 548869 | 0 | 548869 | 548869 | 4.8 % | 16/02/2021 |
| THE MANGROVE PARTNERS MASTER FUND, LTD. | CAYMAN ISLANDS | 0 | 548869 | 0 | 548869 | 548869 | 4.8 % | 16/02/2021 |
| MANGROVE PARTNERS | CAYMAN ISLANDS | 0 | 548869 | 0 | 548869 | 548869 | 4.8 % | 16/02/2021 |
| NATHANIEL AUGUST | UNITED STATES OF AMERICA | 0 | 587464 | 0 | 587464 | 587464 | 5.1 % | 16/02/2021 |
| MANGROVE PARTNERS | CAYMAN ISLANDS | 0 | 587464 | 0 | 587464 | 587464 | 5.1 % | 16/02/2021 |
| THE MANGROVE PARTNERS MASTER FUND, LTD. | CAYMAN ISLANDS | 0 | 587464 | 0 | 587464 | 587464 | 5.1 % | 16/02/2021 |
| Rock Springs Capital Management LP | Delaware | 0 | 555077 | 0 | 555077 | 0 | 5.34 % | 19/10/2020 |
| Rock Springs Capital Management LP | Delaware | 0 | 555077 | 0 | 555077 | 0 | 5.34 % | 19/10/2020 |
| Rock Springs Capital Master Fund LP | Cayman Islands | 0 | 539434 | 0 | 539434 | 0 | 5.19 % | 19/10/2020 |
| Rock Springs Capital Master Fund LP | Cayman Islands | 0 | 539434 | 0 | 539434 | 0 | 5.19 % | 19/10/2020 |
| Rock Springs Capital LLC | Delaware | 0 | 555077 | 0 | 555077 | 0 | 5.34 % | 19/10/2020 |
| Rock Springs Capital LLC | Delaware | 0 | 555077 | 0 | 555077 | 0 | 5.34 % | 19/10/2020 |
| Kevin Kotler | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 13/02/2020 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 13/02/2020 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 13/02/2020 |
| Broadfin Capital, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 13/02/2020 |
| Broadfin Capital, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 13/02/2020 |
| Kevin Kotler | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 13/02/2020 |
| Vivo Opportunity, LLC | Delaware | 1455576 | 0 | 1455576 | 0 | 1455576 | 14 % | 13/02/2020 |
| Vivo Ventures VII, LLC | Delaware | 136715 | 0 | 136715 | 0 | 136715 | 1.3 % | 13/02/2020 |
| Vivo Capital IX, LLC | Delaware | 324783 | 0 | 324783 | 0 | 324783 | 3.1 % | 13/02/2020 |
| New Leaf Venture Management IV, L.L.C | Delaware | 661903 | 5 | 661903 | 0 | 661903 | 6.1 % | 12/02/2020 |
| New Leaf Venture Management III, L.L.C. | Delaware | 125511 | 5 | 125511 | 0 | 125511 | 1.2 % | 12/02/2020 |
| New Leaf Venture Associates IV, L.P. | Delaware | 661903 | 5 | 661903 | 0 | 661903 | 6.1 % | 12/02/2020 |
| New Leaf BPO Associates I, L.P. | Delaware | 125511 | 5 | 125511 | 0 | 125511 | 1.2 % | 12/02/2020 |
| New Leaf Biopharma Opportunities I, L.P. | Delaware | 125511 | 5 | 125511 | 0 | 125511 | 1.2 % | 12/02/2020 |
| New Leaf Ventures IV, L.P. | Delaware | 661903 | 5 | 661903 | 0 | 661903 | 6.1 % | 12/02/2020 |
| Ronald Hunt | United States | 0 | 787414 | 0 | 787414 | 787414 | 7.3 % | 12/02/2020 |
| Vijay Lathi | United States | 0 | 787414 | 0 | 787414 | 787414 | 7.3 % | 12/02/2020 |
| Gilead Sciences, Inc. | Delaware | 1073300 | 0 | 1073300 | 0 | 1073300 | 9.99 % | 10/02/2020 |
| CDK Associates, L.L.C. | Delaware | 0 | 1082200 | 0 | 1082200 | 1082200 | 9.9 % | 03/02/2020 |
| Caxton Corporation | Delaware | 0 | 1082200 | 0 | 1082200 | 1082200 | 9.9 % | 03/02/2020 |
| Bruce S. Kovner | United States | 0 | 1082200 | 0 | 1082200 | 1082200 | 9.9 % | 03/02/2020 |
| Bruce S. Kovner | United States | 0 | 1082200 | 0 | 1082200 | 1082200 | 9.9 % | 03/02/2020 |
| CDK Associates, L.L.C. | Delaware | 0 | 1082200 | 0 | 1082200 | 1082200 | 9.9 % | 03/02/2020 |
| Caxton Corporation | Delaware | 0 | 1082200 | 0 | 1082200 | 1082200 | 9.9 % | 03/02/2020 |
| MANGROVE PARTNERS | CAYMAN ISLANDS | 0 | 7894526 | 0 | 7894526 | 7894526 | 9.99 % | 13/01/2020 |
| NATHANIEL AUGUST | UNITED STATES OF AMERICA | 0 | 7894526 | 0 | 7894526 | 7894526 | 9.99 % | 13/01/2020 |
| THE MANGROVE PARTNERS MASTER FUND, LTD. | CAYMAN ISLANDS | 0 | 7894526 | 0 | 7894526 | 7894526 | 9.99 % | 13/01/2020 |
| Vivo Ventures VII, LLC | Delaware | 5468270 | 0 | 5468270 | 0 | 5468270 | 1.4 % | 25/11/2019 |
| Vivo Capital IX, LLC | Delaware | 12989610 | 0 | 12989610 | 0 | 12989610 | 3.4 % | 25/11/2019 |
| Vivo Opportunity, LLC | Delaware | 58215390 | 0 | 58215390 | 0 | 58215390 | 15.1 % | 25/11/2019 |
| VHCP Holdings III, LLC | 8289478 | 9.99 % | 25/11/2019 | |||||
| Venrock Healthcare Capital Partners II, L.P. | 8289478 | 9.99 % | 25/11/2019 | |||||
| VHCP Management II, LLC | 8289478 | 9.99 % | 25/11/2019 | |||||
| Shah, Nimish | 8289478 | 9.99 % | 25/11/2019 | |||||
| VHCP Holdings II, LLC | 8289478 | 9.99 % | 25/11/2019 | |||||
| VHCP Management III, LLC | 8289478 | 9.99 % | 25/11/2019 | |||||
| Koh, Bong | 8289478 | 9.99 % | 25/11/2019 | |||||
| Venrock Healthcare Capital Partners III, L.P. | 8289478 | 9.99 % | 25/11/2019 | |||||
| Perceptive Advisors LLC | Delaware | 0 | 2666190 | 0 | 2666190 | 2666190 | 3.6 % | 14/02/2019 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 2666190 | 0 | 2666190 | 2666190 | 3.6 % | 14/02/2019 |
| Joseph Edelman | United States America | 0 | 2666190 | 0 | 2666190 | 2666190 | 3.6 % | 14/02/2019 |
| New Leaf BPO Associates I, L.P. | Delaware | 5020446 | 5 | 5020446 | 0 | 5020446 | 6.8 % | 13/02/2019 |
| Liam Ratcliffe | United States | 0 | 5020446 | 0 | 5020446 | 5020446 | 6.8 % | 13/02/2019 |
| Ronald Hunt | United States | 0 | 5020446 | 0 | 5020446 | 5020446 | 6.8 % | 13/02/2019 |
| Vijay Lathi | United States | 0 | 5020446 | 0 | 5020446 | 5020446 | 6.8 % | 13/02/2019 |
| New Leaf Biopharma Opportunities I, L.P. | Delaware | 5020446 | 5 | 5020446 | 0 | 5020446 | 6.8 % | 13/02/2019 |
| New Leaf Venture Management III, L.L.C. | Delaware | 5020446 | 5 | 5020446 | 0 | 5020446 | 6.8 % | 13/02/2019 |
| Broadfin Capital, LLC | Delaware | 0 | 4880327 | 0 | 4880327 | 4880327 | 6.56 % | 13/02/2019 |
| Kevin Kotler | United States America | 0 | 4880327 | 0 | 4880327 | 4880327 | 6.56 % | 13/02/2019 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 4880327 | 0 | 4880327 | 4880327 | 6.56 % | 13/02/2019 |
| OrbiMed Capital GP VI LLC | Delaware | 0 | 417104 | 0 | 417104 | 417104 | 0 % | 12/02/2019 |
| OrbiMed Advisors LLC | Delaware | 0 | 417104 | 0 | 417104 | 0 % | 12/02/2019 | |
| Broadfin Capital, LLC | Delaware | 0 | 4090344 | 0 | 4090344 | 4090344 | 5.5 % | 07/09/2018 |
| Kevin Kotler | United States of America | 0 | 4090344 | 0 | 4090344 | 4090344 | 5.5 % | 07/09/2018 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 4090344 | 0 | 4090344 | 4090344 | 5.5 % | 07/09/2018 |
| Perceptive Advisors LLC | Delaware | 0 | 5000000 | 0 | 5000000 | 5000000 | 9.6 % | 14/02/2018 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 5000000 | 0 | 5000000 | 5000000 | 9.6 % | 14/02/2018 |
| Joseph Edelman | United States America | 0 | 5000000 | 0 | 5000000 | 5000000 | 9.6 % | 14/02/2018 |
| Deerfield Special Situations Fund, L.P. | Delaware | 0 | 1761092 | 0 | 1761092 | 1761092 | 3.37 % | 14/02/2018 |
| Deerfield Management Company, L.P. | Delaware | 0 | 1761092 | 0 | 1761092 | 1761092 | 3.37 % | 14/02/2018 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 1761092 | 0 | 1761092 | 1761092 | 3.37 % | 14/02/2018 |
| James E. Flynn | United States | 0 | 1761092 | 0 | 1761092 | 1761092 | 3.37 % | 14/02/2018 |
| Liam Ratcliffe | United States | 0 | 2798224 | 0 | 2798224 | 2798224 | 5.4 % | 13/02/2018 |
| New Leaf Biopharma Opportunities I, L.P. | Delaware | 2798224 | 5 | 2798224 | 0 | 2798224 | 5.4 % | 13/02/2018 |
| Vijay Lathi | United States | 0 | 2798224 | 0 | 2798224 | 2798224 | 5.4 % | 13/02/2018 |
| New Leaf BPO Associates I, L.P. | Delaware | 2798224 | 5 | 2798224 | 0 | 2798224 | 5.4 % | 13/02/2018 |
| New Leaf Venture Management III, L.L.C. | Delaware | 2798224 | 5 | 2798224 | 0 | 2798224 | 5.4 % | 13/02/2018 |
| Ronald Hunt | United States | 0 | 2798224 | 0 | 2798224 | 2798224 | 5.4 % | 13/02/2018 |
| OrbiMed Capital GP VI LLC | Delaware | 0 | 3203704 | 0 | 3203704 | 3203704 | 6.13 % | 13/02/2018 |
| OrbiMed Advisors LLC | Delaware | 0 | 3203704 | 0 | 3203704 | 6.13 % | 13/02/2018 | |
| Perceptive Advisors LLC | Delaware | 0 | 3655186 | 0 | 3655186 | 3655186 | 7 % | 27/11/2017 |
| Joseph Edelman | United States of America | 0 | 3655186 | 0 | 3655186 | 3655186 | 7 % | 27/11/2017 |
| Perceptive Life Sciences Master Fund, Ltd. | Cayman Islands | 0 | 3655186 | 0 | 3655186 | 3655186 | 7 % | 27/11/2017 |
| S Deerfield International Master Fund, L.P. | British Virgin Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| S Deerfield Management Company, L.P. | Delaware | 0 | 4972319 | 0 | 4972319 | 4972319 | 9.97 % | 14/02/2017 |
| S Deerfield Special Situations Fund, L.P. | Delaware | 0 | 4972319 | 0 | 4972319 | 4972319 | 9.97 % | 14/02/2017 |
| S James E. Flynn | United States | 0 | 4972319 | 0 | 4972319 | 4972319 | 9.97 % | 14/02/2017 |
| S Deerfield Partners, L.P. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| S Deerfield Mgmt, L.P. | Delaware | 0 | 4972319 | 0 | 4972319 | 4972319 | 9.97 % | 14/02/2017 |
| S OrbiMed Capital GP V LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 13/02/2017 |
| S OrbiMed Advisors LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 13/02/2017 |
| S Samuel D. Isaly | United States | 0 | 0 | 0 | 0 | 0 | 0 % | 13/02/2017 |
| FMR LLC | Delaware | 3900 | 0 | 197100 | 0 | 197100 | 0.653 % | 11/07/2016 |
| Abigail P. Johnson | United States of America | 0 | 0 | 197100 | 0 | 197100 | 0.653 % | 11/07/2016 |
| FHM VI, L.P. | Delaware | 0 | 2186195 | 0 | 2186195 | 2186195 | 7.27 % | 16/02/2016 |
| FHM VI, L.L.C. | Delaware | 0 | 2186195 | 0 | 2186195 | 2186195 | 7.27 % | 16/02/2016 |
| Nader Naini | United States Citizen | 0 | 2186195 | 0 | 2186195 | 2186195 | 7.27 % | 16/02/2016 |
| Patrick Heron | United States Citizen | 0 | 2186195 | 0 | 2186195 | 2186195 | 7.27 % | 16/02/2016 |
| Alan Frazier | United States Citizen | 0 | 2186195 | 0 | 2186195 | 2186195 | 7.27 % | 16/02/2016 |
| Nathan Every | United States Citizen | 0 | 2186195 | 0 | 2186195 | 2186195 | 7.27 % | 16/02/2016 |
| James Topper | United States Citizen | 0 | 2186195 | 0 | 2186195 | 2186195 | 7.27 % | 16/02/2016 |
| Frazier Healthcare VI, L.P. | Delaware | 0 | 2186195 | 0 | 2186195 | 2186195 | 7.27 % | 16/02/2016 |
| OrbiMed Capital GP V LLC | Delaware | 0 | 1989949 | 0 | 1989949 | 1989949 | 6.62 % | 16/02/2016 |
| OrbiMed Advisors LLC | Delaware | 0 | 1989949 | 0 | 0 | 1989949 | 6.62 % | 16/02/2016 |
| Samuel D. Isaly | United States | 0 | 1989949 | 0 | 1989949 | 1989949 | 6.62 % | 16/02/2016 |
| Deerfield International Master Fund, L.P. | British Virgin Islands | 0 | 1003104 | 0 | 1003104 | 1003104 | 3.34 % | 16/02/2016 |
| Deerfield Management Company, L.P. | Delaware | 0 | 1791255 | 0 | 1791255 | 1791255 | 5.96 % | 16/02/2016 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 1791255 | 0 | 1791255 | 1791255 | 5.96 % | 16/02/2016 |
| Deerfield Partners, L.P. | Delaware | 0 | 788151 | 0 | 788151 | 788151 | 2.62 % | 16/02/2016 |
| James E. Flynn | United States | 0 | 1791255 | 0 | 1791255 | 1791255 | 5.96 % | 16/02/2016 |
| Vivo Ventures VII, LLC | Delaware | 2438270 | 0 | 2438270 | 0 | 2438270 | 8.1 % | 12/02/2016 |
| Deerfield Management Company, L.P. | Delaware | 0 | 1541128 | 0 | 1541128 | 1541128 | 5.13 % | 09/11/2015 |
| James E. Flynn | United States | 0 | 1541128 | 0 | 1541128 | 1541128 | 5.13 % | 09/11/2015 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 1541128 | 0 | 1541128 | 1541128 | 5.13 % | 09/11/2015 |
| Deerfield Partners, L.P. | Delaware | 0 | 678096 | 0 | 678096 | 678096 | 2.26 % | 09/11/2015 |
| Deerfield International Master Fund, L.P. | British Virgin Islands | 0 | 863032 | 0 | 863032 | 863032 | 2.87 % | 09/11/2015 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 3873531 | 0 | 3873531 | 12.886 % | 10/09/2015 |
| Abigail P. Johnson | United States of America | 0 | 0 | 3873531 | 0 | 3873531 | 12.886 % | 10/09/2015 |
| FMR LLC | Delaware | 125500 | 0 | 3873531 | 0 | 3873531 | 12.886 % | 10/09/2015 |