| Steven Boyd |
United States of America |
0 |
1500063 |
0 |
1500063 |
0 |
0.83 % |
14/11/2024 |
| Armistice Capital, LLC |
Delaware |
0 |
1500063 |
0 |
1500063 |
0 |
0.83 % |
14/11/2024 |
| Alyeska Investment Group, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
| Alyeska Fund GP, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
| Anand Parekh |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
| Ryan M. Lane |
United States |
0 |
1739864 |
0 |
1739864 |
1739864 |
1.34 % |
16/10/2024 |
| Martin D. Hoe |
United States |
0 |
1739864 |
0 |
1739864 |
1739864 |
1.34 % |
16/10/2024 |
| Empery Asset Management, LP |
Delaware |
0 |
1739864 |
0 |
1739864 |
1739864 |
1.34 % |
16/10/2024 |
| L1 Capital Global Opportunities Master Fund, Ltd. |
Cayman Islands |
432187 |
0 |
432187 |
0 |
432187 |
9.99 % |
20/06/2024 |
| Armistice Capital, LLC |
Delaware |
0 |
3770000 |
0 |
3770000 |
0 |
6.71 % |
14/02/2024 |
| Steven Boyd |
United States of America |
0 |
3770000 |
0 |
3770000 |
0 |
6.71 % |
14/02/2024 |
| Anand Parekh |
United States of America |
0 |
5855597 |
0 |
5855597 |
0 |
9.99 % |
14/02/2024 |
| Alyeska Investment Group, L.P. |
Delaware |
0 |
5855597 |
0 |
5855597 |
0 |
9.99 % |
14/02/2024 |
| Alyeska Fund GP, LLC |
Delaware |
0 |
5855597 |
0 |
5855597 |
0 |
9.99 % |
14/02/2024 |
| Martin D. Hoe |
United States |
0 |
2313680 |
0 |
2313680 |
2313680 |
9.99 % |
11/01/2024 |
| Empery Asset Management, LP |
Delaware |
0 |
2313680 |
0 |
2313680 |
2313680 |
9.99 % |
11/01/2024 |
| Ryan M. Lane |
United States |
0 |
2313680 |
0 |
2313680 |
2313680 |
9.99 % |
11/01/2024 |
| Tang Capital Management, LLC |
DELAWARE |
0 |
4280916 |
0 |
4280916 |
4280916 |
7.4 % |
27/12/2022 |
| Kevin Tang |
UNITED STATES |
0 |
4280916 |
0 |
4280916 |
4280916 |
7.4 % |
27/12/2022 |
| Kevin Tang |
UNITED STATES |
0 |
4280916 |
0 |
4280916 |
4280916 |
7.4 % |
27/12/2022 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
4280916 |
0 |
4280916 |
4280916 |
7.4 % |
27/12/2022 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
0 |
4280916 |
0 |
4280916 |
4280916 |
7.4 % |
27/12/2022 |
| Tang Capital Management, LLC |
DELAWARE |
0 |
4280916 |
0 |
4280916 |
4280916 |
7.4 % |
27/12/2022 |
| BlackRock, Inc. |
Delaware |
328277 |
0 |
341736 |
0 |
341736 |
1.1 % |
08/07/2022 |
| BlackRock, Inc. |
Delaware |
29518882 |
0 |
30631558 |
0 |
30631558 |
6.2 % |
04/02/2022 |
| Steven Boyd |
United States America |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Armistice Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
| Heights Capital Management, Inc. |
Delaware |
0 |
111250 |
0 |
111250 |
111250 |
0.1 % |
16/02/2021 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
111250 |
0 |
111250 |
111250 |
0.1 % |
16/02/2021 |
| RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION |
Delaware |
271164 |
0 |
271164 |
0 |
271164 |
0.14 % |
10/02/2021 |
| Renaissance Technologies LLC |
Delaware |
271164 |
0 |
271164 |
0 |
271164 |
0.14 % |
10/02/2021 |
| Sabby Management, LLC |
Delaware, USA |
0 |
100000 |
0 |
100000 |
100000 |
0.05 % |
04/01/2021 |
| Hal Mintz |
USA |
0 |
100000 |
0 |
100000 |
100000 |
0.05 % |
04/01/2021 |
| Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
100000 |
0 |
100000 |
100000 |
0.05 % |
04/01/2021 |
| Heights Capital Management, Inc. |
|
|
|
|
|
1242515 |
9.9 % |
14/02/2020 |
| CVI Investments, Inc. |
|
|
|
|
|
1242515 |
9.9 % |
14/02/2020 |
| RENAISSANCE TECHNOLOGIES HOLDINGS CORPORATION |
Delaware |
320225 |
0 |
320225 |
0 |
320225 |
7.96 % |
12/02/2020 |
| Renaissance Technologies LLC |
Delaware |
320225 |
0 |
320225 |
0 |
320225 |
7.96 % |
12/02/2020 |
| Heights Capital Management, Inc. |
|
|
|
|
|
111250 |
2.7 % |
10/02/2020 |
| CVI Investments, Inc. |
|
|
|
|
|
111250 |
2.7 % |
10/02/2020 |
| Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
1235771 |
0 |
1235771 |
1235771 |
9.99 % |
07/02/2020 |
| Sabby Management, LLC |
Delaware USA |
0 |
1235771 |
0 |
1235771 |
1235771 |
9.99 % |
07/02/2020 |
| Hal Mintz |
USA |
0 |
1235771 |
0 |
1235771 |
1235771 |
9.99 % |
07/02/2020 |
| Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
78605 |
0 |
78605 |
78605 |
4.99 % |
21/01/2020 |
| Hal Mintz |
USA |
0 |
78605 |
0 |
78605 |
78605 |
4.99 % |
21/01/2020 |
| Sabby Management, LLC |
Delaware USA |
0 |
78605 |
0 |
78605 |
78605 |
4.99 % |
21/01/2020 |
| EIN |
Delaware, United States of America |
|
210000 |
0 |
210000 |
210000 |
9.9 % |
25/11/2019 |
| Steven Boyd |
United States of America |
0 |
364476 |
0 |
364476 |
364476 |
9.99 % |
22/11/2019 |
| Armistice Capital Master Fund Ltd. |
Cayman Islands |
0 |
364476 |
0 |
364476 |
364476 |
9.99 % |
22/11/2019 |
| Armistice Capital, LLC |
Delaware |
0 |
364476 |
0 |
364476 |
364476 |
9.99 % |
22/11/2019 |
| CVI Investments, Inc. |
|
|
|
|
|
263579 |
9.9 % |
14/02/2019 |
| Heights Capital Management, Inc. |
|
|
|
|
|
263579 |
9.9 % |
14/02/2019 |
| Hal Mintz |
USA |
0 |
296727 |
0 |
296727 |
296727 |
9.12 % |
07/01/2019 |
| Sabby Management, LLC |
Delaware, USA |
0 |
296727 |
0 |
296727 |
296727 |
9.12 % |
07/01/2019 |
| Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
296727 |
0 |
296727 |
296727 |
9.12 % |
07/01/2019 |
| Anson Funds Management LP |
Texas |
0 |
150000 |
0 |
150000 |
150000 |
6.3 % |
20/12/2018 |
| Moez Kassam |
Canadian Citizen |
0 |
150000 |
0 |
150000 |
150000 |
6.3 % |
20/12/2018 |
| Amin Nathoo |
Canadian Citizen |
0 |
150000 |
0 |
150000 |
150000 |
6.3 % |
20/12/2018 |
| Anson Advisors Inc. |
Ontario, Canada |
0 |
150000 |
0 |
150000 |
150000 |
6.3 % |
20/12/2018 |
| Bruce R. Winson |
United States Citizen |
0 |
150000 |
0 |
150000 |
150000 |
6.3 % |
20/12/2018 |
| Anson Management GP LLC |
Texas |
0 |
150000 |
0 |
150000 |
150000 |
6.3 % |
20/12/2018 |
| Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
175352 |
0 |
175352 |
175352 |
5.39 % |
19/12/2018 |
| Hal Mintz |
USA |
0 |
175352 |
0 |
175352 |
175352 |
5.39 % |
19/12/2018 |
| Sabby Management, LLC |
Delaware USA |
0 |
175352 |
0 |
175352 |
175352 |
5.39 % |
19/12/2018 |
| Richard Abbe |
United States of America |
96454 |
53546 |
96454 |
53546 |
150000 |
9.99 % |
14/12/2018 |
| Iroquois Capital Management L.L.C. |
Delaware |
0 |
53546 |
0 |
53546 |
53546 |
9.99 % |
14/12/2018 |
| Kimberly Page |
United States of America |
0 |
53546 |
0 |
53546 |
53546 |
9.99 % |
14/12/2018 |
| CVI Investments, Inc. |
|
|
|
|
|
243189 |
9.9 % |
14/12/2018 |
| Heights Capital Management, Inc. |
|
|
|
|
|
243189 |
9.9 % |
14/12/2018 |
| Regals Fund LP |
Delaware |
0 |
332351 |
0 |
332351 |
332351 |
3.93 % |
19/06/2018 |
| David M. Slager |
Dutch |
98168 |
430519 |
98168 |
430519 |
430519 |
5.09 % |
19/06/2018 |
| Regals Capital Management LP |
Delaware |
0 |
332351 |
0 |
332351 |
332351 |
3.93 % |
19/06/2018 |
| Rosalind Advisors, Inc. |
ONTARIO, CANADA |
0 |
594077 |
0 |
594077 |
594077 |
7.5 % |
14/02/2018 |
| Rosalind Master Fund L.P. |
CAYMAN ISLANDS |
0 |
594077 |
0 |
594077 |
594077 |
7.5 % |
14/02/2018 |
| Steven Salamon |
ONTARIO, CANADA |
0 |
594077 |
0 |
594077 |
594077 |
7.5 % |
14/02/2018 |
| Felix J. Baker |
United States |
699500 |
0 |
699500 |
0 |
699500 |
8.9 % |
13/02/2018 |
| Baker Bros. Advisors LP |
Delaware |
699500 |
0 |
699500 |
0 |
699500 |
8.9 % |
13/02/2018 |
| Baker Bros. Advisors |
Delaware |
699500 |
0 |
699500 |
0 |
699500 |
8.9 % |
13/02/2018 |
| Julian C. Baker |
United States |
699500 |
0 |
699500 |
0 |
699500 |
8.9 % |
13/02/2018 |
| James Silverman |
United States |
5 |
0 |
0 |
0 |
9 |
0 % |
09/02/2018 |
| Opaleye Management Inc. |
Massachusetts |
5 |
0 |
0 |
0 |
9 |
0 % |
09/02/2018 |
| Opaleye, L.P. |
Delaware |
5 |
0 |
0 |
0 |
9 |
0 % |
09/02/2018 |
| Martin D. Hoe |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
16/01/2018 |
| Ryan M. Lane |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
16/01/2018 |
| Empery Asset Management, LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/01/2018 |
| James Silverman CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
United States |
0 |
413593 |
0 |
413593 |
413593 |
5.52 % |
17/04/2017 |
| CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Massachusetts |
0 |
413593 |
0 |
413593 |
413593 |
5.52 % |
17/04/2017 |
| Opaleye, L.P. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
Delaware |
0 |
413593 |
0 |
413593 |
413593 |
5.52 % |
17/04/2017 |
| Rosalind Master Fund L.P. |
CAYMAN ISLANDS |
0 |
167352 |
0 |
167352 |
167352 |
2.8 % |
07/04/2017 |
| Rosalind Advisors, Inc. |
ONTARIO, CANADA |
0 |
594077 |
0 |
594077 |
594077 |
9.9 % |
07/04/2017 |
| Rosalind Capital Partners L.P. |
ONTARIO, CANADA |
0 |
426725 |
0 |
426725 |
426725 |
7.1 % |
07/04/2017 |
| Steven Salamon |
ONTARIO, CANADA |
0 |
594077 |
0 |
594077 |
594077 |
9.9 % |
07/04/2017 |
| Martin D. Hoe |
United States |
0 |
315000 |
0 |
315000 |
315000 |
5.28 % |
07/04/2017 |
| Ryan M. Lane |
United States |
0 |
315000 |
0 |
315000 |
315000 |
5.28 % |
07/04/2017 |
| Empery Asset Management, LP |
Delaware |
0 |
315000 |
0 |
315000 |
315000 |
5.28 % |
07/04/2017 |
| Kevin Kotler |
United States America |
0 |
353000 |
0 |
353000 |
353000 |
0.89 % |
10/02/2017 |
| Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
353000 |
0 |
353000 |
353000 |
0.89 % |
10/02/2017 |
| Broadfin Capital, LLC |
Delaware |
0 |
353000 |
0 |
353000 |
353000 |
0.89 % |
10/02/2017 |
| CVI Investments, Inc. |
|
|
|
|
|
1177500 |
2.9 % |
10/02/2017 |
| Heights Capital Management, Inc. |
|
|
|
|
|
1177500 |
2.9 % |
10/02/2017 |
| Steven Salamon |
ONTARIO, CANADA |
0 |
2220055 |
0 |
2220055 |
2220055 |
5.7 % |
30/11/2016 |
| Rosalind Advisors, Inc. |
ONTARIO, CANADA |
0 |
2220055 |
0 |
2220055 |
2220055 |
5.7 % |
30/11/2016 |
| Rosalind Capital Partners L.P. |
ONTARIO, CANADA |
0 |
1601077 |
0 |
1601077 |
1601077 |
4 % |
30/11/2016 |
| Rosalind Master Fund L.P. |
CAYMAN ISLANDS |
0 |
618978 |
0 |
618978 |
618978 |
1.6 % |
30/11/2016 |
| Heights Capital Management, Inc. |
Delaware |
0 |
2250000 |
0 |
2250000 |
2250000 |
5.7 % |
04/11/2016 |
| CVI Investments, Inc. |
Cayman Islands |
0 |
2250000 |
0 |
2250000 |
2250000 |
5.7 % |
04/11/2016 |
| Technology Partners Fund VIII, L.P. |
California, United States of America |
0 |
953272 |
0 |
953272 |
953272 |
4.99 % |
02/03/2016 |
| TP Management VIII, LLC |
California, United States of America |
0 |
953272 |
0 |
953272 |
953272 |
4.99 % |
02/03/2016 |
| Kingdon Capital Management, L.L.C. |
Delaware |
0 |
1467858 |
0 |
1467858 |
1467858 |
7.81 % |
16/02/2016 |
| Mark Kingdon |
United States of America |
0 |
1467858 |
0 |
1467858 |
1467858 |
7.81 % |
16/02/2016 |
| Technology Partners Fund VIII, L.P. |
California, United States of America |
0 |
681306 |
0 |
681306 |
681306 |
3.6 % |
10/02/2016 |
| TP Management VIII, LLC |
California, United States of America |
0 |
681306 |
0 |
681306 |
681306 |
3.6 % |
10/02/2016 |
| Technology Partners Fund VIII, L.P. |
California, United States of America |
0 |
681306 |
0 |
681306 |
681306 |
6.3 % |
12/03/2015 |
| TP Management VIII, LLC |
California, United States of America |
0 |
681306 |
0 |
681306 |
681306 |
6.3 % |
12/03/2015 |
| Broadfin Capital, LLC |
Delaware |
0 |
1176639 |
0 |
1176639 |
1176639 |
7.5 % |
17/02/2015 |
| Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
1176639 |
0 |
1176639 |
1176639 |
7.5 % |
17/02/2015 |
| Kevin Kotler |
United States of America |
0 |
1176639 |
0 |
1176639 |
1176639 |
7.5 % |
17/02/2015 |
| Kingdon Capital Management, L.L.C. |
Delaware |
0 |
575000 |
0 |
575000 |
575000 |
5.34 % |
17/02/2015 |
| Mark Kingdon |
United States of America |
0 |
575000 |
0 |
575000 |
575000 |
5.34 % |
17/02/2015 |
| Kevin Kotler |
United States of America |
0 |
501639 |
0 |
501639 |
501639 |
4.7 % |
17/02/2015 |
| Broadfin Capital, LLC |
Delaware |
0 |
501639 |
0 |
501639 |
501639 |
4.7 % |
17/02/2015 |
| Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
501639 |
0 |
501639 |
501639 |
4.7 % |
17/02/2015 |
| James E. Flynn |
United States |
0 |
1365000 |
0 |
1365000 |
1365000 |
8.69 % |
09/02/2015 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
1365000 |
0 |
1365000 |
1365000 |
8.69 % |
09/02/2015 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
1365000 |
0 |
1365000 |
1365000 |
8.69 % |
09/02/2015 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
1365000 |
0 |
1365000 |
1365000 |
8.69 % |
09/02/2015 |
| Sabby Management, LLC |
Delaware USA |
0 |
92400 |
0 |
92400 |
92400 |
1.59 % |
28/01/2014 |
| Hal Mintz |
USA |
0 |
92400 |
0 |
92400 |
92400 |
1.59 % |
28/01/2014 |
| Sabby Healthcare Volatility Master Fund, Ltd. |
Cayman Islands |
0 |
92400 |
0 |
92400 |
92400 |
1.59 % |
28/01/2014 |
| Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
28/01/2014 |
| Broadfin Capital, LLC |
Delaware |
0 |
428000 |
0 |
428000 |
428000 |
8.78 % |
14/08/2013 |
| Kevin Kotler |
United States of America |
0 |
428000 |
0 |
428000 |
428000 |
8.78 % |
14/08/2013 |
| Broadfin Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
428000 |
0 |
428000 |
428000 |
8.78 % |
14/08/2013 |
| Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
120000 |
0 |
120000 |
120000 |
2.46 % |
13/08/2013 |
| Hal Mintz |
USA |
0 |
480000 |
0 |
480000 |
480000 |
9.84 % |
13/08/2013 |
| Sabby Healthcare Volatility Master Fund, Ltd. |
Cayman Islands |
0 |
360000 |
0 |
360000 |
360000 |
7.38 % |
13/08/2013 |
| Sabby Management, LLC |
Delaware USA |
0 |
480000 |
0 |
480000 |
480000 |
9.84 % |
13/08/2013 |
| TECHNOLOGY PARTNERS FUND VIII, LP |
CALIFORNIA, UNITED STATES OF AMERICA |
0 |
4515266 |
0 |
4515266 |
4515266 |
9.99 % |
15/02/2013 |
| TP MANAGEMENT VIII, LLC |
CALIFORNIA, UNITED STATES OF AMERICA |
0 |
4515266 |
0 |
4515266 |
4515266 |
9.99 % |
15/02/2013 |
