Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
BVF II GP LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
Mark N. Lampert |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
BVF Inc. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
BVF GP Holdings LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
BVF I GP LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1513646 |
0 |
1513646 |
1513646 |
4 % |
13/02/2023 |
Mark N. Lampert |
United States |
0 |
3833785 |
0 |
3833785 |
3833785 |
9.98 % |
13/02/2023 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1992047 |
0 |
1992047 |
1992047 |
5.2 % |
13/02/2023 |
BVF Partners L.P. |
Delaware |
0 |
3833785 |
0 |
3833785 |
3833785 |
9.98 % |
13/02/2023 |
BVF Inc. |
Delaware |
0 |
3833785 |
0 |
3833785 |
3833785 |
9.98 % |
13/02/2023 |
BVF II GP LLC |
Delaware |
0 |
1513646 |
0 |
1513646 |
1513646 |
4 % |
13/02/2023 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
260654 |
0 |
260654 |
260654 |
1 % |
13/02/2023 |
BVF I GP LLC |
Delaware |
0 |
1992047 |
0 |
1992047 |
1992047 |
5.2 % |
13/02/2023 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
260654 |
0 |
260654 |
260654 |
1 % |
13/02/2023 |
BVF GP Holdings LLC |
Delaware |
0 |
3505693 |
0 |
3505693 |
3505693 |
9.1 % |
13/02/2023 |
BlackRock, Inc. |
Delaware |
542312 |
0 |
542431 |
0 |
542431 |
1.4 % |
08/07/2022 |
Laurence W. Lytton |
USA |
255876 |
0 |
255876 |
0 |
255876 |
0.7 % |
15/02/2022 |
Mark N. Lampert |
United States |
0 |
3731744 |
0 |
3731744 |
3731744 |
9.9 % |
14/02/2022 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1828558 |
0 |
1828558 |
1828558 |
4.9 % |
14/02/2022 |
BVF I GP LLC |
Delaware |
0 |
1828558 |
0 |
1828558 |
1828558 |
4.9 % |
14/02/2022 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1551694 |
0 |
1551694 |
1551694 |
4.2 % |
14/02/2022 |
BVF II GP LLC |
Delaware |
0 |
1551694 |
0 |
1551694 |
1551694 |
4.2 % |
14/02/2022 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
276511 |
0 |
276511 |
276511 |
0 % |
14/02/2022 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
276511 |
0 |
276511 |
276511 |
0 % |
14/02/2022 |
BVF GP Holdings LLC |
Delaware |
0 |
3380252 |
0 |
3380252 |
3380252 |
9 % |
14/02/2022 |
BVF Partners L.P. |
Delaware |
0 |
3731744 |
0 |
3731744 |
3731744 |
9.9 % |
14/02/2022 |
BVF Inc. |
Delaware |
0 |
3731744 |
0 |
3731744 |
3731744 |
9.9 % |
14/02/2022 |
Aisling Capital Partners IV LLC |
Delaware |
0 |
288571 |
0 |
288571 |
288571 |
0.77 % |
14/02/2022 |
Andrew N. Schiff |
United States of America |
0 |
288571 |
0 |
288571 |
288571 |
0.77 % |
14/02/2022 |
Aisling Capital Partners IV, LP |
Delaware |
0 |
288571 |
0 |
288571 |
288571 |
0.77 % |
14/02/2022 |
Aisling Capital IV, LP |
Delaware |
0 |
288571 |
0 |
288571 |
288571 |
0.77 % |
14/02/2022 |
Steve Elms |
United States of America |
0 |
288571 |
0 |
288571 |
288571 |
0.77 % |
14/02/2022 |
Forward Ventures V, L.P. |
Delaware |
2664790 |
5 |
2664790 |
0 |
2664790 |
7.14 % |
09/02/2022 |
Forward Ventures V, L.P. |
Delaware |
2622274 |
5 |
2622274 |
0 |
2622274 |
7.09 % |
08/03/2021 |
LVP III Associates, L.P. (“Associates”) |
|
|
|
|
|
145055 |
0.39 % |
05/03/2021 |
Patrick F. Latterell (“Latterell”) |
|
|
|
|
|
3124094 |
8.44 % |
05/03/2021 |
LVPMC, LLC (“LVPMC”) |
|
|
|
|
|
5361 |
0.01 % |
05/03/2021 |
LVP GP III, LLC (“GP III”) |
|
|
|
|
|
3118733 |
8.43 % |
05/03/2021 |
LVP Life Science Ventures III, L.P. (“LVP III”) |
|
|
|
|
|
2901152 |
7.84 % |
05/03/2021 |
LVP III Partners, L.P. (“Partners”) |
|
|
|
|
|
72526 |
0.2 % |
05/03/2021 |
LVP Life Science Ventures III, L.P. (“LVP III”) |
|
|
|
|
|
2901152 |
7.84 % |
03/03/2021 |
LVP III Associates, L.P. (“Associates”) |
|
|
|
|
|
145055 |
0.39 % |
03/03/2021 |
Patrick F. Latterell (“Latterell”) |
|
|
|
|
|
3124094 |
8.44 % |
03/03/2021 |
LVP III Partners, L.P. (“Partners”) |
|
|
|
|
|
72526 |
0.2 % |
03/03/2021 |
LVP GP III, LLC (“GP III”) |
|
|
|
|
|
3118733 |
8.43 % |
03/03/2021 |
LVPMC, LLC (“LVPMC”) |
|
|
|
|
|
5361 |
0.01 % |
03/03/2021 |
Caxton Corporation |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
Caxton Alternative Management LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
Bruce S. Kovner |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
CDK Trading, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
Waqas Khatri |
Pakistan |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
Ayrton Capital LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
Alto Opportunity Master Fund, SPC Segregated Master Portfolio B |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
CVI Investments, Inc. |
Cayman Islands |
|
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
Heights Capital Management, Inc. |
Delaware |
|
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
Daniel Mack |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
Wilmot B. Harkey |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
Nantahala Capital Management, LLC |
MA |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2021 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
119592 |
0 |
119592 |
119592 |
1 % |
12/02/2021 |
BVF Inc. |
Delaware |
0 |
1814308 |
0 |
1814308 |
1814308 |
9.98 % |
12/02/2021 |
BVF Partners L.P. |
Delaware |
0 |
1814308 |
0 |
1814308 |
1814308 |
9.98 % |
12/02/2021 |
Mark N. Lampert |
United States |
0 |
1814308 |
0 |
1814308 |
1814308 |
9.98 % |
12/02/2021 |
BVF II GP LLC |
Delaware |
0 |
663035 |
0 |
663035 |
663035 |
3.7 % |
12/02/2021 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
119592 |
0 |
119592 |
119592 |
1 % |
12/02/2021 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
663035 |
0 |
663035 |
663035 |
3.7 % |
12/02/2021 |
BVF I GP LLC |
Delaware |
0 |
981881 |
0 |
981881 |
981881 |
5.4 % |
12/02/2021 |
BVF GP HOLDINGS LLC |
Delaware |
0 |
1644916 |
0 |
1644916 |
1644916 |
8.7 % |
12/02/2021 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
981881 |
0 |
981881 |
981881 |
5.4 % |
12/02/2021 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
07/01/2021 |
Sabby Management, LLC |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
07/01/2021 |
Hal Mintz |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
07/01/2021 |
Laurence W. Lytton |
USA |
1582219 |
16300 |
1582219 |
16300 |
1598519 |
8.8 % |
04/01/2021 |
Alto Opportunity Master Fund, SPC Segregated Master Portfolio B |
Cayman Islands |
10869565 |
0 |
10869565 |
0 |
10869565 |
6.65 % |
07/08/2020 |
Waqas Khatri |
Pakistan |
10869565 |
0 |
10869565 |
0 |
10869565 |
6.65 % |
07/08/2020 |
Ayrton Capital LLC |
Delaware |
10869565 |
0 |
10869565 |
0 |
10869565 |
6.65 % |
07/08/2020 |
CVI Investments, Inc. |
Cayman Islands |
0 |
8695652 |
0 |
8695652 |
8695652 |
5.3 % |
03/08/2020 |
Heights Capital Management, Inc. |
Delaware |
0 |
8695652 |
0 |
8695652 |
8695652 |
5.3 % |
03/08/2020 |
Sabby Management, LLC |
Delaware USA |
0 |
10869565 |
0 |
10869565 |
10869565 |
6.65 % |
29/07/2020 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
10869565 |
0 |
10869565 |
10869565 |
6.65 % |
29/07/2020 |
Hal Mintz |
USA |
0 |
10869565 |
0 |
10869565 |
10869565 |
6.65 % |
29/07/2020 |
Avidity Partners Management LP |
Delaware |
0 |
4951925 |
0 |
4951925 |
4951925 |
4.4 % |
11/03/2020 |
Avidity Partners Management |
Delaware |
0 |
4951925 |
0 |
4951925 |
4951925 |
4.4 % |
11/03/2020 |
Avidity Capital Partners Fund |
Delaware |
0 |
4951925 |
0 |
4951925 |
4951925 |
4.4 % |
11/03/2020 |
Avidity Capital Partners |
Delaware |
0 |
4951925 |
0 |
4951925 |
4951925 |
4.4 % |
11/03/2020 |
David Witzke |
United States of America |
0 |
4951925 |
0 |
4951925 |
4951925 |
4.4 % |
11/03/2020 |
Michael Gregory |
United States of America |
0 |
4951925 |
0 |
4951925 |
4951925 |
4.4 % |
11/03/2020 |
Samsara BioCapital, L.P. |
Delaware |
0 |
5938215 |
0 |
5938215 |
5938215 |
5.3 % |
05/03/2020 |
Samsara BioCapital GP, LLC |
Delaware |
0 |
5938215 |
0 |
5938215 |
5938215 |
5.3 % |
05/03/2020 |
Srinivas Akkaraju |
United States of America |
0 |
5938215 |
0 |
5938215 |
5938215 |
5.3 % |
05/03/2020 |
BVF Inc. |
Delaware |
0 |
11653925 |
0 |
11653925 |
11653925 |
9.98 % |
14/02/2020 |
BVF Partners L.P. |
Delaware |
0 |
11653925 |
0 |
11653925 |
11653925 |
9.98 % |
14/02/2020 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
7987685 |
0 |
7987685 |
7987685 |
6.9 % |
14/02/2020 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
657555 |
0 |
657555 |
657555 |
0 % |
14/02/2020 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
657555 |
0 |
657555 |
657555 |
0 % |
14/02/2020 |
BVF II GP LLC |
Delaware |
0 |
2775318 |
0 |
2775318 |
2775318 |
2.5 % |
14/02/2020 |
Mark N. Lampert |
United States |
0 |
11653925 |
0 |
11653925 |
11653925 |
9.98 % |
14/02/2020 |
BVF GP HOLDINGS LLC |
Delaware |
0 |
10763003 |
0 |
10763003 |
10763003 |
9.2 % |
14/02/2020 |
BVF I GP LLC |
Delaware |
0 |
7987685 |
0 |
7987685 |
7987685 |
6.9 % |
14/02/2020 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
2775318 |
0 |
2775318 |
2775318 |
2.5 % |
14/02/2020 |
Atlas Institutional Fund, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
Atlas Enhanced Master Fund, Ltd. |
Cayman |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
Atlas Global Japan Unit Trust |
Cayman |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
Dmitry Balyasny |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
Balyasny Asset Management L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
Atlas Enhanced Fund, Ltd. |
Cayman |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
Atlas Enhanced Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
Atlas Institutional Fund, Ltd. |
Cayman |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
Atlas Global Investments, Ltd. |
Cayman |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
Atlas Global, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
Atlas Master Fund, Ltd. |
Cayman |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
CDK Trading, LLC |
Delaware |
0 |
8134926 |
0 |
8134926 |
8134926 |
7.3 % |
14/02/2020 |
Bruce S. Kovner |
United States |
0 |
8134926 |
0 |
8134926 |
8134926 |
7.3 % |
14/02/2020 |
Caxton Corporation |
Delaware |
0 |
8134926 |
0 |
8134926 |
8134926 |
7.3 % |
14/02/2020 |
Caxton Alternative Management LP |
Delaware |
0 |
8134926 |
0 |
8134926 |
8134926 |
7.3 % |
14/02/2020 |
Roderick Wong |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
RTW Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
RTW Investments, LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
Wilmot B. Harkey |
USA |
0 |
8765600 |
0 |
8765600 |
8765600 |
7.9 % |
14/02/2020 |
Daniel Mack |
USA |
0 |
8765600 |
0 |
8765600 |
8765600 |
7.9 % |
14/02/2020 |
Nantahala Capital Management, LLC |
MA |
0 |
8765600 |
0 |
8765600 |
8765600 |
7.9 % |
14/02/2020 |
expressly disclaim status as a “group” for purposes of this Schedule 13G. 1. Name of Reporting Persons MPM Oncology Impact Management GP LLC |
Delaware |
2809912 |
0 |
2809912 |
0 |
2809912 |
2.5 % |
05/02/2020 |
UBS Oncology Impact Fund L.P. |
Cayman Islands |
2809912 |
0 |
2809912 |
0 |
2809912 |
2.5 % |
05/02/2020 |
expressly disclaim status as a “group” for purposes of this Schedule 13G. 1. Name of Reporting Persons Oncology Impact Fund |
Cayman Islands |
2809912 |
0 |
2809912 |
0 |
2809912 |
2.5 % |
05/02/2020 |
expressly disclaim status as a “group” for purposes of this Schedule 13G. 1. Name of Reporting Persons MPM Oncology Impact Management LP |
Delaware |
2809912 |
0 |
2809912 |
0 |
2809912 |
2.5 % |
05/02/2020 |
Eventide Asset Management, LLC |
|
0 |
|
|
|
0 |
0 % |
04/02/2020 |
RTW Master Fund, Ltd. |
Cayman Islands |
0 |
5309185 |
0 |
5309185 |
0 |
5.3 % |
22/07/2019 |
RTW Investments, LP |
Delaware |
0 |
6916079 |
0 |
6916079 |
6916079 |
6.9 % |
22/07/2019 |
Roderick Wong |
United States of America |
0 |
6916079 |
0 |
6916079 |
6916079 |
6.9 % |
22/07/2019 |
Caxton Corporation |
Delaware |
0 |
5345826 |
0 |
5345826 |
5345826 |
5.3 % |
19/07/2019 |
CDK Trading, LLC |
Delaware |
0 |
5345826 |
0 |
5345826 |
5345826 |
5.3 % |
19/07/2019 |
Caxton Alternative Management LP |
Delaware |
0 |
5345826 |
0 |
5345826 |
5345826 |
5.3 % |
19/07/2019 |
Bruce S. Kovner |
United States |
0 |
5345826 |
0 |
5345826 |
5345826 |
5.3 % |
19/07/2019 |
OR |
United States |
0 |
10100000 |
0 |
10100000 |
10100000 |
10 % |
15/07/2019 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1276934 |
0 |
1276934 |
1276934 |
3.4 % |
14/02/2019 |
Mark N. Lampert |
United States |
0 |
3895026 |
0 |
3895026 |
3895026 |
9.98 % |
14/02/2019 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
2140172 |
0 |
2140172 |
2140172 |
5.5 % |
14/02/2019 |
BVF Inc. |
Delaware |
0 |
3895026 |
0 |
3895026 |
3895026 |
9.98 % |
14/02/2019 |
BVF Partners L.P. |
Delaware |
0 |
3895026 |
0 |
3895026 |
3895026 |
9.98 % |
14/02/2019 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
47429 |
0 |
47429 |
47429 |
0 % |
14/02/2019 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
47429 |
0 |
47429 |
47429 |
0 % |
14/02/2019 |
Joe Lewis |
United Kingdom |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2019 |
Boxer Asset Management Inc. |
Bahamas |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2019 |
Boxer Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2019 |
Balyasny Asset Management L.P. |
Delaware |
2200000 |
0 |
2200000 |
0 |
2200000 |
5.88 % |
14/02/2019 |
Atlas Master Fund, Ltd. |
Cayman |
317647 |
0 |
317647 |
0 |
317647 |
0.85 % |
14/02/2019 |
Atlas Global, LLC |
Delaware |
317647 |
0 |
317647 |
0 |
317647 |
0.85 % |
14/02/2019 |
Atlas Global Investments, Ltd. |
Cayman |
317647 |
0 |
317647 |
0 |
317647 |
0.85 % |
14/02/2019 |
Atlas Institutional Fund, LLC |
Delaware |
317647 |
0 |
317647 |
0 |
317647 |
0.85 % |
14/02/2019 |
Atlas Institutional Fund, Ltd. |
Cayman |
317647 |
0 |
317647 |
0 |
317647 |
0.85 % |
14/02/2019 |
Atlas Global Japan Unit Trust |
Cayman |
317647 |
0 |
317647 |
0 |
317647 |
0.85 % |
14/02/2019 |
Atlas Enhanced Master Fund, Ltd. |
Cayman |
1882353 |
0 |
1882353 |
0 |
1882353 |
5.03 % |
14/02/2019 |
Atlas Enhanced Fund, L.P. |
Delaware |
1882353 |
0 |
1882353 |
0 |
1882353 |
5.03 % |
14/02/2019 |
Atlas Enhanced Fund, Ltd. |
Cayman |
1882353 |
0 |
1882353 |
0 |
1882353 |
5.03 % |
14/02/2019 |
Dmitry Balyasny |
United States |
2200000 |
0 |
2200000 |
0 |
2200000 |
5.88 % |
14/02/2019 |
Eventide Asset Management, LLC |
Delaware |
2265455 |
0 |
2265455 |
0 |
2265455 |
6.1 % |
13/02/2019 |
Steven Boyd |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
28/01/2019 |
Armistice Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
28/01/2019 |
Armistice Capital Master Fund Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
28/01/2019 |
JFL Capital Management LLC |
Delaware, U.S. |
1967527 |
4935481 |
1967527 |
4935481 |
4935481 |
8.17 % |
25/01/2019 |
OR |
United States |
0 |
7600000 |
0 |
7600000 |
7600000 |
12.6 % |
24/01/2019 |
RA Capital Management, LLC |
Massachusetts |
0 |
5000001 |
0 |
5000001 |
5000001 |
1.4 % |
10/07/2018 |
Peter Kolchinsky |
United States |
0 |
5000001 |
0 |
5000001 |
5000001 |
1.4 % |
10/07/2018 |
Boxer Capital, LLC |
Delaware |
0 |
2125000 |
0 |
2125000 |
2125000 |
6.2 % |
05/03/2018 |
Joe Lewis |
United Kingdom |
0 |
2125000 |
0 |
2125000 |
2125000 |
6.2 % |
05/03/2018 |
Boxer Asset Management Inc. |
Bahamas |
0 |
2125000 |
0 |
2125000 |
2125000 |
6.2 % |
05/03/2018 |
Anthony Joonkyoo Yun, MD |
U.S.A. |
0 |
1162473 |
0 |
1162473 |
1162473 |
3.39 % |
14/02/2018 |
Palo Alto Investors, LLC |
California |
0 |
1162473 |
0 |
1162473 |
1162473 |
3.39 % |
14/02/2018 |
Patrick Lee, MD |
U.S.A. |
0 |
1162473 |
0 |
1162473 |
1162473 |
3.39 % |
14/02/2018 |
Mr. David Kroin |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
Great Point Partners, LLC |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2018 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
200941 |
0 |
200941 |
200941 |
0 % |
14/02/2018 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
859660 |
0 |
859660 |
859660 |
2.4 % |
14/02/2018 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
200941 |
0 |
200941 |
200941 |
0 % |
14/02/2018 |
BVF Partners L.P. |
Delaware |
0 |
3570362 |
0 |
3570362 |
3570362 |
9.98 % |
14/02/2018 |
Mark N. Lampert |
United States |
0 |
3570362 |
0 |
3570362 |
3570362 |
9.98 % |
14/02/2018 |
BVF Inc. |
Delaware |
0 |
3570362 |
0 |
3570362 |
3570362 |
9.98 % |
14/02/2018 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1634037 |
0 |
1634037 |
1634037 |
4.6 % |
14/02/2018 |
Atlas Institutional Fund, LLC |
Delaware |
249151 |
0 |
249151 |
0 |
249151 |
0.73 % |
14/02/2018 |
Atlas Institutional Fund, Ltd. |
Cayman |
249151 |
0 |
249151 |
0 |
249151 |
0.73 % |
14/02/2018 |
Atlas Global Japan Unit Trust |
Cayman |
249151 |
0 |
249151 |
0 |
249151 |
0.73 % |
14/02/2018 |
Atlas Enhanced Master Fund, Ltd. |
Cayman |
1454349 |
0 |
1454349 |
0 |
1454349 |
4.25 % |
14/02/2018 |
Atlas Enhanced Fund, L.P. |
Delaware |
1454349 |
0 |
1454349 |
0 |
1454349 |
4.25 % |
14/02/2018 |
Atlas Master Fund, Ltd. |
Cayman |
249151 |
0 |
249151 |
0 |
249151 |
0.73 % |
14/02/2018 |
Atlas Global, LLC |
Delaware |
249151 |
0 |
249151 |
0 |
249151 |
0.73 % |
14/02/2018 |
Atlas Global Investments, Ltd. |
Cayman |
249151 |
0 |
249151 |
0 |
249151 |
0.73 % |
14/02/2018 |
Atlas Enhanced Fund, Ltd. |
Cayman |
1454349 |
0 |
1454349 |
0 |
1454349 |
4.25 % |
14/02/2018 |
Atlas Fundamental Trading Master Fund, Ltd. |
Cayman |
496500 |
0 |
496500 |
0 |
496500 |
1.45 % |
14/02/2018 |
Atlas Fundamental Trading Fund, L.P. |
Delaware |
496500 |
0 |
496500 |
0 |
496500 |
1.45 % |
14/02/2018 |
Atlas Fundamental Trading Fund, Ltd. |
Cayman |
496500 |
0 |
496500 |
0 |
496500 |
1.45 % |
14/02/2018 |
Balyasny Asset Management L.P. |
Delaware |
2200000 |
0 |
2200000 |
0 |
2200000 |
6.42 % |
14/02/2018 |
Dmitry Balyasny |
United States |
2200000 |
0 |
2200000 |
0 |
2200000 |
6.42 % |
14/02/2018 |
Fariba Ghodsian |
United States of America |
983000 |
0 |
983000 |
0 |
983000 |
2.87 % |
13/02/2018 |
DAFNA Capital Management, LLC |
Delaware |
983000 |
0 |
983000 |
0 |
983000 |
2.87 % |
13/02/2018 |
Nathan Fischel |
Austria citizen (U.S. permanent resident) |
983000 |
0 |
983000 |
0 |
983000 |
2.87 % |
13/02/2018 |
Eventide Asset Management, LLC |
Delaware |
2265455 |
0 |
2265455 |
0 |
2265455 |
6.6 % |
12/02/2018 |
OR |
United States |
0 |
2975000 |
0 |
2975000 |
2975000 |
8.6 % |
07/02/2018 |
MPM Oncology Impact Management GP LLC |
Delaware |
4956500 |
0 |
4956500 |
0 |
4956500 |
13.8 % |
06/02/2018 |
UBS Oncology Impact Fund L.P. |
Cayman Islands |
4956500 |
0 |
4956500 |
0 |
4956500 |
13.8 % |
06/02/2018 |
Oncology Impact Fund |
Cayman Islands |
4956500 |
0 |
4956500 |
0 |
4956500 |
13.8 % |
06/02/2018 |
MPM Oncology Impact Management LP |
Delaware |
4956500 |
0 |
4956500 |
0 |
4956500 |
13.8 % |
06/02/2018 |
RA Capital Management, LLC |
Massachusetts |
0 |
35968401 |
0 |
35968401 |
35968401 |
10.4 % |
13/11/2017 |
Peter Kolchinsky |
United States |
0 |
35968401 |
0 |
35968401 |
35968401 |
10.4 % |
13/11/2017 |
expressly disclaim status as a “group” for purposes of this Schedule 13G. 1. Name of Reporting Persons MPM Oncology Impact Management GP LLC |
Delaware |
4875000 |
0 |
4875000 |
0 |
4875000 |
12.5 % |
06/11/2017 |
UBS Oncology Impact Fund L.P. |
Cayman Islands |
4875000 |
0 |
4875000 |
0 |
4875000 |
12.5 % |
06/11/2017 |
expressly disclaim status as a “group” for purposes of this Schedule 13G. 1. Name of Reporting Persons MPM Oncology Impact Management LP |
Delaware |
4875000 |
0 |
4875000 |
0 |
4875000 |
12.5 % |
06/11/2017 |
expressly disclaim status as a “group” for purposes of this Schedule 13G. 1. Name of Reporting Persons Oncology Impact Fund |
Cayman Islands |
4875000 |
0 |
4875000 |
0 |
4875000 |
12.5 % |
06/11/2017 |
Atlas Enhanced Master Fund, Ltd. |
Cayman |
1310494 |
0 |
1310494 |
0 |
1310494 |
6.11 % |
05/07/2017 |
Atlas Institutional Fund, Ltd. |
Cayman |
224506 |
0 |
224506 |
0 |
224506 |
1.05 % |
05/07/2017 |
Atlas Institutional Fund, LLC |
Delaware |
224506 |
0 |
224506 |
0 |
224506 |
1.05 % |
05/07/2017 |
Atlas Global Investments, Ltd. |
Cayman |
224506 |
0 |
224506 |
0 |
224506 |
1.05 % |
05/07/2017 |
Atlas Global, LLC |
Delaware |
224506 |
0 |
224506 |
0 |
224506 |
1.05 % |
05/07/2017 |
Atlas Master Fund, Ltd. |
Cayman |
224506 |
0 |
224506 |
0 |
224506 |
1.05 % |
05/07/2017 |
Dmitry Balyasny |
United States |
2000000 |
0 |
2000000 |
0 |
2000000 |
9.32 % |
05/07/2017 |
Balyasny Asset Management L.P. |
Delaware |
2000000 |
0 |
2000000 |
0 |
2000000 |
9.32 % |
05/07/2017 |
Atlas Fundamental Trading Fund, Ltd. |
Cayman |
465000 |
0 |
465000 |
0 |
465000 |
2.17 % |
05/07/2017 |
Atlas Fundamental Trading Fund, L.P. |
Delaware |
465000 |
0 |
465000 |
0 |
465000 |
2.17 % |
05/07/2017 |
Atlas Fundamental Trading Master Fund, Ltd. |
Cayman |
465000 |
0 |
465000 |
0 |
465000 |
2.17 % |
05/07/2017 |
Atlas Enhanced Fund, Ltd. |
Cayman |
1310494 |
0 |
1310494 |
0 |
1310494 |
6.11 % |
05/07/2017 |
Atlas Enhanced Fund, L.P. |
Delaware |
1310494 |
0 |
1310494 |
0 |
1310494 |
6.11 % |
05/07/2017 |
Atlas Global Japan Unit Trust |
Cayman |
224506 |
0 |
224506 |
0 |
224506 |
1.05 % |
05/07/2017 |
Jacob Gottlieb |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
Visium Asset Management, LP |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
JG Asset, LLC |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
Cormorant Global Healthcare GP, LLC |
Delaware |
0 |
831500 |
0 |
831500 |
831500 |
3.98 % |
14/02/2017 |
Bihua Chen |
United States |
0 |
1000000 |
0 |
1000000 |
1000000 |
4.79 % |
14/02/2017 |
Cormorant Asset Management, LLC |
Delaware |
0 |
1000000 |
0 |
1000000 |
1000000 |
4.79 % |
14/02/2017 |
Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
0 |
831500 |
0 |
831500 |
831500 |
3.98 % |
14/02/2017 |
Baker Bros. Advisors |
Delaware |
741665 |
0 |
741665 |
0 |
741665 |
3.6 % |
14/02/2017 |
Julian C. Baker |
United States |
741665 |
0 |
741665 |
0 |
741665 |
3.6 % |
14/02/2017 |
Felix J. Baker |
United States |
741665 |
0 |
741665 |
0 |
741665 |
3.6 % |
14/02/2017 |
Baker Bros. Advisors LP |
Delaware |
741665 |
0 |
741665 |
0 |
741665 |
3.6 % |
14/02/2017 |
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
USA |
0 |
19878711 |
0 |
19878711 |
19878711 |
9.32 % |
14/02/2017 |
Mr. David Kroin |
USA |
0 |
19878711 |
0 |
19878711 |
19878711 |
9.32 % |
14/02/2017 |
Great Point Partners, LLC |
USA |
0 |
19878711 |
0 |
19878711 |
19878711 |
9.32 % |
14/02/2017 |
Fariba Ghodsian |
United States of America |
1133583 |
0 |
1133583 |
0 |
1133583 |
5.43 % |
14/02/2017 |
Nathan Fischel |
Austria citizen (U.S. permanent resident) |
1133583 |
0 |
1133583 |
0 |
1133583 |
5.43 % |
14/02/2017 |
DAFNA Capital Management, LLC |
Delaware |
1133583 |
0 |
1133583 |
0 |
1133583 |
5.43 % |
14/02/2017 |
BVF Inc. |
Delaware |
0 |
2160295 |
0 |
2160295 |
2160295 |
9.98 % |
14/02/2017 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1145105 |
0 |
1145105 |
1145105 |
5.3 % |
14/02/2017 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
203109 |
0 |
203109 |
203109 |
0 % |
14/02/2017 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
73350 |
0 |
73350 |
73350 |
0 % |
14/02/2017 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
73350 |
0 |
73350 |
73350 |
0 % |
14/02/2017 |
BVF Partners L.P. |
Delaware |
0 |
2160295 |
0 |
2160295 |
2160295 |
9.98 % |
14/02/2017 |
Mark N. Lampert |
United States |
0 |
2160295 |
0 |
2160295 |
2160295 |
9.98 % |
14/02/2017 |
Anthony Joonkyoo Yun, MD |
U.S.A. |
0 |
1162473 |
0 |
1162473 |
1162473 |
5.57 % |
12/01/2017 |
Palo Alto Investors, LLC |
California |
0 |
1162473 |
0 |
1162473 |
1162473 |
5.57 % |
12/01/2017 |
Patrick Lee, MD |
U.S.A. |
0 |
1162473 |
0 |
1162473 |
1162473 |
5.57 % |
12/01/2017 |
OR |
United States |
0 |
1293574 |
0 |
1293574 |
1293574 |
6.2 % |
06/01/2017 |
Cormorant Global Healthcare GP, LLC |
Delaware |
|
|
|
|
831500 |
4.28 % |
31/10/2016 |
Cormorant Global Healthcare Master Fund, LP |
Cayman Islands |
|
|
|
|
831500 |
4.28 % |
31/10/2016 |
Bihua Chen |
United States |
|
|
|
|
1000000 |
5.14 % |
31/10/2016 |
Cormorant Asset Management, LLC |
Delaware |
|
|
|
|
1000000 |
5.14 % |
31/10/2016 |
FMR LLC |
Delaware |
0 |
0 |
2049739 |
0 |
2049739 |
2.357 % |
10/06/2016 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2049739 |
0 |
2049739 |
2.357 % |
10/06/2016 |
BVF Partners L.P. |
Delaware |
0 |
8902230 |
0 |
8902230 |
8902230 |
9.98 % |
16/02/2016 |
BVF Inc. |
Delaware |
0 |
8902230 |
0 |
8902230 |
8902230 |
9.98 % |
16/02/2016 |
BVF Partners OS Ltd. |
Cayman Islands |
0 |
429814 |
0 |
429814 |
429814 |
0 % |
16/02/2016 |
Mark N. Lampert |
United States |
0 |
8902230 |
0 |
8902230 |
8902230 |
9.98 % |
16/02/2016 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1218654 |
0 |
1218654 |
1218654 |
1.4 % |
16/02/2016 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
6226952 |
0 |
6226952 |
6226952 |
7 % |
16/02/2016 |
Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
429814 |
0 |
429814 |
429814 |
0 % |
16/02/2016 |
Felix J. Baker |
United States |
4450000 |
0 |
4450000 |
0 |
4450000 |
5.1 % |
16/02/2016 |
Baker Bros. Advisors |
Delaware |
4450000 |
0 |
4450000 |
0 |
4450000 |
5.1 % |
16/02/2016 |
Baker Bros. Advisors LP |
Delaware |
4450000 |
0 |
4450000 |
0 |
4450000 |
5.1 % |
16/02/2016 |
Julian C. Baker |
United States |
4450000 |
0 |
4450000 |
0 |
4450000 |
5.1 % |
16/02/2016 |
Palo Alto Investors, LLC |
California |
0 |
6974854 |
0 |
6974854 |
6974854 |
8.2 % |
16/02/2016 |
Anthony Joonkyoo Yun, MD |
U.S.A. |
0 |
6974854 |
0 |
6974854 |
6974854 |
8.2 % |
16/02/2016 |
Patrick Lee, MD |
U.S.A. |
0 |
6974854 |
0 |
6974854 |
6974854 |
8.2 % |
16/02/2016 |
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
USA |
0 |
85123851 |
0 |
85123851 |
85123851 |
9.98 % |
16/02/2016 |
Great Point Partners, LLC |
USA |
0 |
85123851 |
0 |
85123851 |
85123851 |
9.98 % |
16/02/2016 |
Mr. David Kroin |
USA |
0 |
85123851 |
0 |
85123851 |
85123851 |
9.98 % |
16/02/2016 |
Jacob Gottlieb |
United States |
0 |
400000 |
0 |
400000 |
400000 |
0.5 % |
12/02/2016 |
JG Asset, LLC |
United States |
0 |
400000 |
0 |
400000 |
400000 |
0.5 % |
12/02/2016 |
Visium Asset Management, LP |
United States |
0 |
400000 |
0 |
400000 |
400000 |
0.5 % |
12/02/2016 |
T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2016 |
Great Point Partners, LLC |
USA |
0 |
85123501 |
0 |
85123501 |
85123501 |
9.98 % |
28/12/2015 |
2. CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP |
USA |
0 |
85123501 |
0 |
85123501 |
85123501 |
9.98 % |
28/12/2015 |
Mr. David Kroin |
USA |
0 |
85123501 |
0 |
85123501 |
85123501 |
9.98 % |
28/12/2015 |
Visium Balanced Master Fund, Ltd. |
Cayman Islands |
0 |
3876190 |
0 |
3876190 |
3876190 |
5.7 % |
30/03/2015 |
JG Asset, LLC |
United States |
0 |
3876190 |
0 |
3876190 |
3876190 |
5.7 % |
30/03/2015 |
Visium Asset Management, LP |
United States |
0 |
3876190 |
0 |
3876190 |
3876190 |
5.7 % |
30/03/2015 |
Jacob Gottlieb |
United States |
0 |
3876190 |
0 |
3876190 |
3876190 |
5.7 % |
30/03/2015 |
Kenneth Griffin |
U.S. Citizen |
0 |
2598372 |
0 |
2598372 |
2598372 |
4.2 % |
17/02/2015 |
Citadel Advisors LLC |
Delaware |
0 |
2575572 |
0 |
2575572 |
2575572 |
4.2 % |
17/02/2015 |
Citadel Advisors Holdings II LP |
Delaware |
0 |
2575572 |
0 |
2575572 |
2575572 |
4.2 % |
17/02/2015 |
Citadel GP LLC |
Delaware |
0 |
2598372 |
0 |
2598372 |
2598372 |
4.2 % |
17/02/2015 |
Peter Kolchinsky |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
RA Capital Management, LLC |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
Baker Bros. Advisors LP |
Delaware |
3200000 |
0 |
3200000 |
0 |
3200000 |
5.2 % |
17/02/2015 |
Baker Bros. Advisors |
Delaware |
3200000 |
0 |
3200000 |
0 |
3200000 |
5.2 % |
17/02/2015 |
Felix J. Baker |
United States |
3200000 |
0 |
3200000 |
0 |
3200000 |
5.2 % |
17/02/2015 |
Julian C. Baker |
United States |
3200000 |
0 |
3200000 |
0 |
3200000 |
5.2 % |
17/02/2015 |
BVF Inc. |
Delaware |
0 |
3136000 |
0 |
3136000 |
3136000 |
5.1 % |
13/02/2015 |
Investment 10, L.L.C. |
Illinois |
0 |
403968 |
0 |
403968 |
403968 |
0 % |
13/02/2015 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
751449 |
0 |
751449 |
751449 |
1.2 % |
13/02/2015 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1449842 |
0 |
1449842 |
1449842 |
2.3 % |
13/02/2015 |
MSI BVF SPV, LLC |
Delaware |
0 |
530741 |
0 |
530741 |
530741 |
0 % |
13/02/2015 |
BVF Partners L.P. |
Delaware |
0 |
3136000 |
0 |
3136000 |
3136000 |
5.1 % |
13/02/2015 |
Mark N. Lampert |
United States |
0 |
3136000 |
0 |
3136000 |
3136000 |
5.1 % |
13/02/2015 |
Jacob Gottlieb |
United States |
0 |
2004546 |
0 |
2004546 |
2004546 |
3.2 % |
13/02/2015 |
Visium Asset Management, LP |
United States |
0 |
2004546 |
0 |
2004546 |
2004546 |
3.2 % |
13/02/2015 |
JG Asset, LLC |
United States |
0 |
2004546 |
0 |
2004546 |
2004546 |
3.2 % |
13/02/2015 |
FMR LLC |
Delaware |
0 |
0 |
5083834 |
0 |
5083834 |
8.206 % |
13/02/2015 |
Abigail P. Johnson |
United States of America |
0 |
0 |
5083834 |
0 |
5083834 |
8.206 % |
13/02/2015 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
5083834 |
0 |
5083834 |
8.206 % |
13/02/2015 |
Select Biotechnology Portfolio |
Massachusetts |
4253594 |
0 |
0 |
0 |
4253594 |
6.866 % |
13/02/2015 |
Farah Champsi |
United States |
0 |
832909 |
0 |
832909 |
832909 |
1.3 % |
12/02/2015 |
Alta BioPharma Partners III, L.P. |
Delaware |
762879 |
0 |
762879 |
0 |
762879 |
1.2 % |
12/02/2015 |
Alta BioPharma Partners III GmbH & Co. Beteiligungs KG |
Germany |
51231 |
0 |
51231 |
0 |
51231 |
0.1 % |
12/02/2015 |
Alta BioPharma Management III, LLC |
Delaware |
0 |
814110 |
0 |
814110 |
814110 |
1.3 % |
12/02/2015 |
Alta Embarcadero BioPharma Partners III, LLC |
California |
18799 |
0 |
18799 |
0 |
18799 |
0.1 % |
12/02/2015 |
Edward Penhoet |
United States |
0 |
832909 |
0 |
832909 |
832909 |
1.3 % |
12/02/2015 |
T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
5670000 |
9.1 % |
11/02/2015 |
BVF Inc. |
Delaware |
0 |
3166000 |
0 |
3166000 |
3166000 |
5.1 % |
14/11/2014 |
BVF Partners L.P. |
Delaware |
0 |
3166000 |
0 |
3166000 |
3166000 |
5.1 % |
14/11/2014 |
MSI BVF SPV, LLC |
Delaware |
0 |
531972 |
0 |
531972 |
531972 |
0 % |
14/11/2014 |
Investment 10, L.L.C. |
Illinois |
0 |
407419 |
0 |
407419 |
407419 |
0 % |
14/11/2014 |
Biotechnology Value Fund, L.P. |
Delaware |
0 |
1467135 |
0 |
1467135 |
1467135 |
2.4 % |
14/11/2014 |
Biotechnology Value Fund II, L.P. |
Delaware |
0 |
759474 |
0 |
759474 |
759474 |
1.2 % |
14/11/2014 |
Mark N. Lampert |
United States |
0 |
3166000 |
0 |
3166000 |
3166000 |
5.1 % |
14/11/2014 |
T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
6235500 |
10.3 % |
10/10/2014 |
Citadel Advisors LLC |
Delaware |
0 |
3061129 |
0 |
3061129 |
3061129 |
5.1 % |
22/09/2014 |
Kenneth Griffin |
U.S. Citizen |
0 |
3174816 |
0 |
3174816 |
3174816 |
5.3 % |
22/09/2014 |
Citadel GP LLC |
Delaware |
0 |
3174816 |
0 |
3174816 |
3174816 |
5.3 % |
22/09/2014 |
Citadel Advisors Holdings II LP |
Delaware |
0 |
3061129 |
0 |
3061129 |
3061129 |
5.1 % |
22/09/2014 |
Visium Balanced Master Fund, Ltd. |
Cayman Islands |
0 |
4116415 |
0 |
4116415 |
4116415 |
7.6 % |
14/02/2014 |
Jacob Gottlieb |
United States |
0 |
4126598 |
0 |
4126598 |
4126598 |
7.6 % |
14/02/2014 |
Visium Asset Management, LP |
United States |
0 |
4126598 |
0 |
4126598 |
4126598 |
7.6 % |
14/02/2014 |
JG Asset, LLC |
United States |
0 |
4126598 |
0 |
4126598 |
4126598 |
7.6 % |
14/02/2014 |
RA Capital Management, LLC |
Massachusetts |
0 |
4869261 |
0 |
4869261 |
4869261 |
9 % |
14/02/2014 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
3335303 |
0 |
3335303 |
3335303 |
6.2 % |
14/02/2014 |
Peter Kolchinsky |
United States |
0 |
4869261 |
0 |
4869261 |
4869261 |
9 % |
14/02/2014 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
4621258 |
0 |
4621258 |
8.561 % |
14/02/2014 |
FMR LLC |
Delaware |
2070163 |
0 |
4621258 |
0 |
4621258 |
8.561 % |
14/02/2014 |
T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
3651300 |
6.7 % |
13/02/2014 |
BlackRock, Inc. |
Delaware |
2087795 |
0 |
2120531 |
0 |
2120531 |
3.9 % |
07/02/2014 |
BlackRock, Inc. |
Delaware |
2685969 |
0 |
2718705 |
0 |
2718705 |
5 % |
30/01/2014 |
I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) |
Delaware |
0 |
484400 |
0 |
484400 |
484400 |
0.9 % |
22/01/2014 |
SS or Edward Penhoet |
United States |
0 |
3651189 |
0 |
3651189 |
3651189 |
6.66 % |
14/01/2014 |
SS or Farah Champsi |
United States |
0 |
3651189 |
0 |
3651189 |
3651189 |
6.66 % |
14/01/2014 |
SS or Alta Embarcadero BioPharma Partners III, LLC |
California |
82412 |
0 |
82412 |
0 |
82412 |
0.15 % |
14/01/2014 |
SS or Alta BioPharma Management III, LLC |
Delaware |
0 |
3568777 |
0 |
3568777 |
3568777 |
6.51 % |
14/01/2014 |
Alta BioPharma Partners III GmbH & Co. Beteiligungs KG |
Germany |
224586 |
0 |
224586 |
0 |
224586 |
0.42 % |
14/01/2014 |
Alta BioPharma Partners III, L.P. |
Delaware |
3344191 |
0 |
3344191 |
0 |
3344191 |
6.11 % |
14/01/2014 |
SS or Edward Hurwitz |
United States |
0 |
3651189 |
0 |
3651189 |
3651189 |
6.66 % |
14/01/2014 |
FMR LLC |
Delaware |
3187972 |
0 |
6545767 |
0 |
6545767 |
12.71 % |
11/03/2013 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
6545767 |
0 |
6545767 |
12.71 % |
11/03/2013 |
Visium Balanced Master Fund, Ltd. |
Cayman Islands |
0 |
4476190 |
0 |
4476190 |
4476190 |
8.7 % |
14/02/2013 |
Visium Asset Management, LP |
United States |
0 |
4476988 |
0 |
4476988 |
4476988 |
8.7 % |
14/02/2013 |
Jacob Gottlieb |
United States |
0 |
4476988 |
0 |
4476988 |
4476988 |
8.7 % |
14/02/2013 |
JG Asset, LLC |
United States |
0 |
4476988 |
0 |
4476988 |
4476988 |
8.7 % |
14/02/2013 |
Peter Kolchinsky |
United States |
4887230 |
0 |
4887230 |
0 |
4887230 |
9.5 % |
14/02/2013 |
RA Capital Management, LLC |
Massachusetts |
4887230 |
0 |
4887230 |
0 |
4887230 |
9.5 % |
14/02/2013 |
RA Capital Healthcare Fund, L.P. |
Delaware |
2972132 |
0 |
2972132 |
0 |
2972132 |
5.8 % |
14/02/2013 |
Merlin BioMed Private Equity Advisors, LLC |
Delaware |
0 |
2975363 |
0 |
2975363 |
2975363 |
6.2 % |
13/02/2013 |
Dominique Sémon |
Switzerland |
0 |
2975363 |
0 |
2975363 |
2975363 |
6.2 % |
13/02/2013 |
Merlin Nexus III, L.P. |
Delaware |
0 |
1820050 |
0 |
1820050 |
1820050 |
3.8 % |
13/02/2013 |
Nexus Gemini, L.P. |
Delaware |
0 |
1155313 |
0 |
1155313 |
1155313 |
2.4 % |
13/02/2013 |
BlackRock, Inc. |
Delaware |
2637784 |
0 |
2637784 |
0 |
2637784 |
5.12 % |
30/01/2013 |
Peter Kolchinsky |
United States |
2538846 |
0 |
2538846 |
0 |
2538846 |
5.4 % |
26/09/2012 |
RA Capital Healthcare Fund, L.P. |
Delaware |
1532207 |
0 |
1532207 |
0 |
1532207 |
3.3 % |
26/09/2012 |
RA Capital Management, LLC |
Massachusetts |
2538846 |
0 |
2538846 |
0 |
2538846 |
5.4 % |
26/09/2012 |
JG Asset, LLC |
United States |
0 |
4476190 |
0 |
4476190 |
4476190 |
9.41 % |
21/09/2012 |
Visium Asset Management, LP |
United States |
0 |
4476190 |
0 |
4476190 |
4476190 |
9.41 % |
21/09/2012 |
Visium Balanced Master Fund, Ltd. |
Cayman Islands |
0 |
4476190 |
0 |
4476190 |
4476190 |
9.41 % |
21/09/2012 |
Jacob Gottlieb |
United States |
0 |
4476190 |
0 |
4476190 |
4476190 |
9.41 % |
21/09/2012 |
Biogen Idec MA Inc. |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2012 |
Biogen Idec Inc. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2012 |
Merlin Nexus III, L.P. |
Delaware |
0 |
1820050 |
0 |
1820050 |
1820050 |
3.9 % |
08/02/2012 |
Nexus Gemini, L.P. |
Delaware |
0 |
1262147 |
0 |
1262147 |
1262147 |
2.7 % |
08/02/2012 |
Merlin BioMed Private Equity Advisors, LLC |
Delaware |
0 |
3082197 |
0 |
3082197 |
3082197 |
6.6 % |
08/02/2012 |
Dominique Sémon |
Switzerland |
0 |
3082197 |
0 |
3082197 |
3082197 |
6.6 % |
08/02/2012 |
Caxton Associates LP |
Delaware |
0 |
9223076 |
0 |
9223076 |
9223076 |
3.5 % |
14/02/2011 |
Kovner, Bruce |
United States |
|
9223076 |
|
9223076 |
9223076 |
3.5 % |
14/02/2011 |
Caxton Advantage Life Sciences Fund, L.P. |
Delaware |
0 |
9223076 |
0 |
9223076 |
9223076 |
3.5 % |
14/02/2011 |
Advantage Life Sciences Partners, LLC |
Delaware |
0 |
9223076 |
0 |
9223076 |
9223076 |
3.5 % |
14/02/2011 |
Leheny, Rachel |
United States |
0 |
9223076 |
0 |
9223076 |
9223076 |
3.5 % |
14/02/2011 |
Caxton Advantage Venture Partners, L.P. |
Delaware |
0 |
9223076 |
0 |
9223076 |
9223076 |
3.5 % |
14/02/2011 |
CHHA LLC |
Delaware |
0 |
9223076 |
0 |
9223076 |
9223076 |
3.5 % |
14/02/2011 |
Roberts, Eric |
United States |
0 |
9223076 |
0 |
9223076 |
9223076 |
3.5 % |
14/02/2011 |
Venrock Associates |
New York, United States |
0 |
67638802 |
0 |
67638802 |
67638802 |
2.5 % |
14/02/2011 |
Venrock Associates II, L.P. |
New York, United States |
0 |
67638802 |
0 |
67638802 |
67638802 |
2.5 % |
14/02/2011 |
Roberts, Eric |
United States |
0 |
1085898 |
0 |
1085898 |
1085898 |
4 % |
11/02/2011 |
CHHA LLC |
Delaware |
0 |
1085898 |
0 |
1085898 |
1085898 |
4 % |
11/02/2011 |
Caxton Health Holdings LLC |
Delaware |
0 |
1085898 |
0 |
1085898 |
1085898 |
4 % |
11/02/2011 |
Leheny, Rachel |
United States |
0 |
1085898 |
0 |
1085898 |
1085898 |
4 % |
11/02/2011 |
Caxton Associates LP |
Delaware |
0 |
1085898 |
0 |
1085898 |
1085898 |
4 % |
11/02/2011 |
Kovner, Bruce |
United States |
0 |
1085898 |
0 |
1085898 |
1085898 |
4 % |
11/02/2011 |
Caxton Advantage Life Sciences Fund, L.P. |
Delaware |
0 |
1085898 |
0 |
1085898 |
1085898 |
4 % |
11/02/2011 |
Caxton Advantage Venture Partners, L.P. |
Delaware |
0 |
1085898 |
0 |
1085898 |
1085898 |
4 % |
11/02/2011 |
Advantage Life Sciences Partners, LLC |
Delaware |
0 |
1085898 |
0 |
1085898 |
1085898 |
4 % |
11/02/2011 |
Merlin Nexus III, L.P. |
Delaware |
0 |
10920308 |
0 |
10920308 |
10920308 |
4.3 % |
11/02/2011 |
Merlin BioMed Private Equity Advisors, LLC |
Delaware |
0 |
18504506 |
0 |
18504506 |
18504506 |
7.3 % |
11/02/2011 |
Dominique Sémon |
Switzerland |
0 |
18504506 |
0 |
18504506 |
18504506 |
7.3 % |
11/02/2011 |
Nexus Gemini, L.P. |
Delaware |
0 |
7584198 |
0 |
7584198 |
7584198 |
3 % |
11/02/2011 |
Roberts, Eric |
United States |
0 |
2498740 |
0 |
2498740 |
2498740 |
6.8 % |
25/02/2010 |
Kovner, Bruce |
United States |
|
2498740 |
|
2498740 |
2498740 |
6.8 % |
25/02/2010 |
Caxton Advantage Life Sciences Fund, L.P. |
Delaware |
0 |
2498740 |
0 |
2498740 |
2498740 |
6.8 % |
25/02/2010 |
Advantage Life Sciences Partners, LLC |
Delaware |
0 |
2498740 |
0 |
2498740 |
2498740 |
6.8 % |
25/02/2010 |
CHHA LLC |
Delaware |
0 |
2498740 |
0 |
2498740 |
2498740 |
6.8 % |
25/02/2010 |
Leheny, Rachel |
United States |
0 |
2498740 |
0 |
2498740 |
2498740 |
6.8 % |
25/02/2010 |
Caxton Associates LP |
Delaware |
0 |
2498740 |
0 |
2498740 |
2498740 |
6.8 % |
25/02/2010 |
Caxton Advantage Venture Partners, L.P. |
Delaware |
0 |
2498740 |
0 |
2498740 |
2498740 |
6.8 % |
25/02/2010 |
Vision Capital Advisors, LLC |
Delaware |
0 |
999500 |
0 |
999500 |
999500 |
2.7 % |
16/02/2010 |
Adam Benowitz |
United States |
0 |
999500 |
0 |
999500 |
999500 |
2.7 % |
16/02/2010 |
Vision Opportunity Master Fund, Ltd. |
Cayman Islands |
0 |
999500 |
0 |
999500 |
999500 |
2.7 % |
16/02/2010 |
Venrock Associates II, L.P. |
New York, United States |
0 |
19989902 |
0 |
19989902 |
19989902 |
5.3 % |
16/02/2010 |
Venrock Associates |
New York, United States |
0 |
19989902 |
0 |
19989902 |
19989902 |
5.3 % |
16/02/2010 |
CREDIT SUISSE AG/ |
Switzerland |
0 |
1206590 |
0 |
1206590 |
1206590 |
3.51 % |
16/02/2010 |
BristolMyers Squibb Company |
Delaware |
1283134 |
0 |
1283134 |
0 |
1283134 |
3.7 % |
12/02/2010 |
Merlin Nexus III, L.P. |
Delaware |
0 |
5997000 |
0 |
5997000 |
5997000 |
7.7 % |
26/01/2010 |
Merlin Nexus II, L.P. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
26/01/2010 |
Dominique Sémon |
Switzerland |
0 |
10194880 |
0 |
10194880 |
10194880 |
13.1 % |
26/01/2010 |
Merlin BioMed Private Equity Advisors, LLC |
Delaware |
0 |
10194880 |
0 |
10194880 |
10194880 |
13.1 % |
26/01/2010 |
Nexus Gemini, L.P. |
Delaware |
0 |
4197880 |
0 |
4197880 |
4197880 |
5.4 % |
26/01/2010 |