| Wellington Management Company LLP |
Massachusetts |
0 |
3891905 |
0 |
0 |
4039058 |
5.4 % |
08/02/2024 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3914121 |
0 |
0 |
4162654 |
5.56 % |
08/02/2024 |
| Wellington Group Holdings LLP |
Massachusetts |
0 |
3914121 |
0 |
0 |
4162654 |
5.56 % |
08/02/2024 |
| Wellington Investment Advisors Holdings LLP |
Massachusetts |
0 |
3914121 |
0 |
0 |
4162654 |
5.56 % |
08/02/2024 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
14541 |
0 |
14541 |
14541 |
4 % |
14/02/2022 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
2992597 |
0 |
2992597 |
2992597 |
4 % |
14/02/2022 |
| Steven A. Cohen |
Delaware |
0 |
3007138 |
0 |
3007138 |
3007138 |
4 % |
14/02/2022 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
2992597 |
0 |
2992597 |
2992597 |
4 % |
14/02/2022 |
| DRIEHAUS CAPITAL MANAGEMENT LLC |
|
0 |
3123229 |
0 |
3123229 |
3123229 |
6.05 % |
14/02/2022 |
| OrbiMed Capital LLC |
Delaware |
631000 |
0 |
631000 |
0 |
631000 |
1.22 % |
11/02/2022 |
| OrbiMed Advisors LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| Behzad Aghazadeh |
Delaware |
4985000 |
0 |
4985000 |
0 |
4985000 |
9.7 % |
11/02/2022 |
| Avoro Capital Advisors LLC |
Delaware |
4985000 |
0 |
4985000 |
0 |
4985000 |
9.7 % |
11/02/2022 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
665000 |
0 |
0 |
665000 |
1.29 % |
10/02/2022 |
| Phillip Gross |
United States |
0 |
665000 |
0 |
0 |
665000 |
1.29 % |
10/02/2022 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
665000 |
0 |
0 |
665000 |
1.29 % |
10/02/2022 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
665000 |
0 |
0 |
665000 |
1.29 % |
10/02/2022 |
| Robert Atchinson |
United States |
0 |
665000 |
0 |
0 |
665000 |
1.29 % |
10/02/2022 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
17093 |
0 |
17093 |
17093 |
4 % |
28/10/2021 |
| Steven A. Cohen |
Delaware |
0 |
2641253 |
0 |
2641253 |
2641253 |
4 % |
28/10/2021 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
2624160 |
0 |
2624160 |
2624160 |
4 % |
28/10/2021 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
2624160 |
0 |
2624160 |
2624160 |
4 % |
28/10/2021 |
| Vivo Opportunity, LLC |
Delaware |
881310 |
0 |
881310 |
0 |
881310 |
2.9 % |
13/02/2020 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
1925000 |
0 |
0 |
1925000 |
7.44 % |
12/02/2020 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
1925000 |
0 |
0 |
1925000 |
7.44 % |
12/02/2020 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
1925000 |
0 |
0 |
1925000 |
7.44 % |
12/02/2020 |
| Robert Atchinson |
United States |
0 |
1925000 |
0 |
0 |
1925000 |
7.44 % |
12/02/2020 |
| Phillip Gross |
United States |
0 |
1925000 |
0 |
0 |
1925000 |
7.44 % |
12/02/2020 |
| Behzad Aghazadeh |
United States |
2400000 |
0 |
2400000 |
0 |
2400000 |
9.5 % |
14/02/2019 |
| venBio Select Advisor LLC |
Delaware |
2400000 |
0 |
2400000 |
0 |
2400000 |
9.5 % |
14/02/2019 |
| SMALLCAP World Fund, Inc. |
Maryland |
0 |
0 |
0 |
0 |
1900900 |
7.5 % |
13/02/2019 |
| Vivo
Opportunity, LLC |
OR PLACE OF ORGANIZATION |
1048333 |
0 |
1048333 |
0 |
1048333 |
5.6 % |
13/07/2018 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
800000 |
0 |
0 |
800000 |
5.64 % |
03/07/2018 |
| Robert Atchinson |
United States |
0 |
800000 |
0 |
0 |
800000 |
5.64 % |
03/07/2018 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
800000 |
0 |
0 |
800000 |
5.64 % |
03/07/2018 |
| Phillip Gross |
United States |
0 |
800000 |
0 |
0 |
800000 |
5.64 % |
03/07/2018 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
800000 |
0 |
0 |
800000 |
5.64 % |
03/07/2018 |
| Capital World Investors ** |
Delaware |
1429000 |
0 |
1429000 |
0 |
1429000 |
7.9 % |
13/02/2018 |
| Samuel D. Isaly |
United States |
0 |
1000000 |
0 |
0 |
1000000 |
5.59 % |
13/02/2017 |
| OrbiMed Capital GP VI LLC |
Delaware |
0 |
1000000 |
0 |
0 |
1000000 |
5.59 % |
13/02/2017 |
| OrbiMed Advisors LLC |
Delaware |
0 |
1000000 |
0 |
0 |
1000000 |
5.59 % |
13/02/2017 |
| Teva Canada Limited |
Israel |
0 |
1111111 |
0 |
0 |
1111111 |
7.7 % |
29/03/2016 |
| Teva Pharmaceutical Industries Limited |
Israel |
0 |
1111111 |
0 |
0 |
1111111 |
7.7 % |
29/03/2016 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
494659 |
0 |
0 |
494659 |
3.4 % |
18/03/2016 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
767168 |
0 |
0 |
767168 |
5.3 % |
18/03/2016 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
152736 |
0 |
0 |
152736 |
1.1 % |
18/03/2016 |
| BVF Partners OS Ltd. |
Delaware |
0 |
152736 |
0 |
0 |
152736 |
1.1 % |
18/03/2016 |
| BVF Inc. |
Delaware |
0 |
1775572 |
0 |
0 |
1775572 |
12.3 % |
18/03/2016 |
| BVF Partners L.P. |
Delaware |
0 |
1775572 |
0 |
0 |
1775572 |
12.3 % |
18/03/2016 |
| Mark N. Lampert |
Delaware |
0 |
1775572 |
0 |
0 |
1775572 |
12.3 % |
18/03/2016 |
| August J. Troendle |
United States |
1077241 |
0 |
1077241 |
0 |
1077241 |
7.49 % |
26/02/2016 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
910920 |
0 |
910920 |
6.405 % |
12/02/2016 |
| Select Biotechnology Portfolio |
Massachusetts |
808705 |
0 |
0 |
0 |
808705 |
5.686 % |
12/02/2016 |
| FMR LLC |
Delaware |
0 |
0 |
910920 |
0 |
910920 |
6.405 % |
12/02/2016 |
| MSI BVF SPV, LLC |
Delaware |
0 |
117399 |
0 |
0 |
117399 |
1 % |
10/07/2015 |
| BVF Partners L.P. |
Delaware |
0 |
821264 |
0 |
0 |
821264 |
5.8 % |
10/07/2015 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
229601 |
0 |
0 |
229601 |
1.6 % |
10/07/2015 |
| Mark N. Lampert |
Delaware |
0 |
821264 |
0 |
0 |
821264 |
5.8 % |
10/07/2015 |
| Investment 10, L.L.C. |
Delaware |
0 |
73793 |
0 |
0 |
73793 |
1 % |
10/07/2015 |
| BVF Inc. |
Delaware |
0 |
821264 |
0 |
0 |
821264 |
5.8 % |
10/07/2015 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
400471 |
0 |
0 |
400471 |
2.8 % |
10/07/2015 |
| 2 |
Ohio |
0 |
1038964 |
0 |
1038964 |
1038964 |
7.33 % |
17/02/2015 |
| 2 |
Ohio |
0 |
1038964 |
0 |
1038964 |
1038964 |
7.33 % |
17/02/2015 |
| 2 |
Ohio |
11250 |
1038964 |
11250 |
1038964 |
1050214 |
7.41 % |
17/02/2015 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1256239 |
0 |
1256239 |
9.278 % |
13/02/2015 |
| FMR LLC |
United States of America |
345319 |
0 |
1256239 |
0 |
1256239 |
9.278 % |
13/02/2015 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
1256239 |
0 |
1256239 |
9.278 % |
13/02/2015 |
| Select Biotechnology Portfolio |
United States of America |
808705 |
0 |
0 |
0 |
808705 |
5.973 % |
13/02/2015 |
| August J. Troendle |
United States |
1171959 |
0 |
1171959 |
0 |
1171959 |
8.26 % |
12/01/2015 |
| Investment 10, L.L.C. |
Delaware |
0 |
73724 |
0 |
0 |
73724 |
1 % |
14/11/2014 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
172710 |
0 |
0 |
172710 |
1.3 % |
14/11/2014 |
| BVF Partners L.P. |
Delaware |
0 |
703724 |
0 |
0 |
703724 |
5.2 % |
14/11/2014 |
| MSI BVF SPV, LLC |
Delaware |
0 |
123021 |
0 |
0 |
123021 |
1 % |
14/11/2014 |
| BVF Inc. |
Delaware |
0 |
703724 |
0 |
0 |
703724 |
5.2 % |
14/11/2014 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
334269 |
0 |
0 |
334269 |
2.5 % |
14/11/2014 |
| Mark N. Lampert |
Delaware |
0 |
703724 |
0 |
0 |
703724 |
5.2 % |
14/11/2014 |