| Wellington Group Holdings LLP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
06/02/2023 |
| Wellington Management Group LLP |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
06/02/2023 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
06/02/2023 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
267526 |
0 |
267526 |
267526 |
0 % |
03/01/2023 |
| BVF II GP LLC |
Delaware |
0 |
2370712 |
0 |
2370712 |
2370712 |
3.8 % |
03/01/2023 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
267526 |
0 |
267526 |
267526 |
0 % |
03/01/2023 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
267526 |
0 |
267526 |
267526 |
0 % |
03/01/2023 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
2370712 |
0 |
2370712 |
2370712 |
3.8 % |
03/01/2023 |
| BVF II GP LLC |
Delaware |
0 |
2370712 |
0 |
2370712 |
2370712 |
3.8 % |
03/01/2023 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
267526 |
0 |
267526 |
267526 |
0 % |
03/01/2023 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
2370712 |
0 |
2370712 |
2370712 |
3.8 % |
03/01/2023 |
| BVF I GP LLC |
Delaware |
0 |
3146377 |
0 |
3146377 |
3146377 |
5 % |
03/01/2023 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
3146377 |
0 |
3146377 |
3146377 |
5 % |
03/01/2023 |
| BVF GP Holdings LLC |
Delaware |
0 |
5517089 |
0 |
5517089 |
5517089 |
8.8 % |
03/01/2023 |
| BVF Partners L.P. |
Delaware |
0 |
5870000 |
0 |
5870000 |
5870000 |
9.3 % |
03/01/2023 |
| BVF Inc. |
Delaware |
0 |
5870000 |
0 |
5870000 |
5870000 |
9.3 % |
03/01/2023 |
| Mark N. Lampert |
United States |
0 |
5870000 |
0 |
5870000 |
5870000 |
9.3 % |
03/01/2023 |
| Mark N. Lampert |
United States |
0 |
5870000 |
0 |
5870000 |
5870000 |
9.3 % |
03/01/2023 |
| BVF Inc. |
Delaware |
0 |
5870000 |
0 |
5870000 |
5870000 |
9.3 % |
03/01/2023 |
| BVF Partners L.P. |
Delaware |
0 |
5870000 |
0 |
5870000 |
5870000 |
9.3 % |
03/01/2023 |
| BVF GP Holdings LLC |
Delaware |
0 |
5517089 |
0 |
5517089 |
5517089 |
8.8 % |
03/01/2023 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
3146377 |
0 |
3146377 |
3146377 |
5 % |
03/01/2023 |
| BVF I GP LLC |
Delaware |
0 |
3146377 |
0 |
3146377 |
3146377 |
5 % |
03/01/2023 |
| Redmile Biopharma Investments III, L.P. |
Delaware |
0 |
3164847 |
0 |
3164847 |
3164847 |
5.5 % |
08/08/2022 |
| Jeremy C. Green |
United Kingdom |
0 |
5758241 |
0 |
5758241 |
5758241 |
9.9 % |
08/08/2022 |
| Redmile Group, LLC |
Delaware |
0 |
5758241 |
0 |
5758241 |
5758241 |
9.9 % |
08/08/2022 |
| Redmile Biopharma Investments III, L.P. |
Delaware |
0 |
3164847 |
0 |
3164847 |
3164847 |
5.5 % |
08/08/2022 |
| Jeremy C. Green |
United Kingdom |
0 |
5758241 |
0 |
5758241 |
5758241 |
9.9 % |
08/08/2022 |
| Redmile Group, LLC |
Delaware |
0 |
5758241 |
0 |
5758241 |
5758241 |
9.9 % |
08/08/2022 |
| FMR LLC |
Delaware |
687348 |
0 |
687348 |
0 |
687348 |
1.19 % |
10/03/2022 |
| FMR LLC |
Delaware |
687348 |
0 |
687348 |
0 |
687348 |
1.19 % |
10/03/2022 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
687348 |
0 |
687348 |
1.19 % |
10/03/2022 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
687348 |
0 |
687348 |
1.19 % |
10/03/2022 |
| Joseph Edelman |
United States of America |
0 |
3679845 |
0 |
3679845 |
3679845 |
6.6 % |
14/02/2022 |
| Perceptive Life Sciences Master Fund, Ltd. |
Cayman Islands |
0 |
3679845 |
0 |
3679845 |
3679845 |
6.6 % |
14/02/2022 |
| Perceptive Advisors LLC |
Delaware |
0 |
3679845 |
0 |
3679845 |
3679845 |
6.6 % |
14/02/2022 |
| Felix J. Baker |
United States |
4977296 |
0 |
4977296 |
0 |
4977296 |
9.99 % |
14/02/2022 |
| Julian C. Baker |
United States |
4977296 |
0 |
4977296 |
0 |
4977296 |
9.99 % |
14/02/2022 |
| Baker Bros. Advisors LLC |
Delaware |
4977296 |
0 |
4977296 |
0 |
4977296 |
9.99 % |
14/02/2022 |
| Baker Bros. Advisors LP |
Delaware |
4977296 |
0 |
4977296 |
0 |
4977296 |
9.99 % |
14/02/2022 |
| GOLDMAN SACHS & CO. LLC |
New York |
0 |
2414975 |
0 |
2415045 |
2415045 |
5.2 % |
10/02/2022 |
| THE GOLDMAN SACHS GROUP, INC. |
Delaware |
0 |
2414975 |
0 |
2415045 |
2415045 |
5.2 % |
10/02/2022 |
| Millennium Management LLC |
|
|
|
|
|
2513592 |
4.4 % |
10/02/2022 |
| Millennium Group Management LLC |
|
|
|
|
|
2513592 |
4.4 % |
10/02/2022 |
| Israel A. Englander |
|
|
|
|
|
2513592 |
4.4 % |
10/02/2022 |
| FMR LLC |
Delaware |
210765 |
0 |
3491547 |
0 |
3491547 |
7.499 % |
09/02/2022 |
| FMR LLC |
Delaware |
210765 |
0 |
3491547 |
0 |
3491547 |
7.499 % |
09/02/2022 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
3491547 |
0 |
3491547 |
7.499 % |
09/02/2022 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
3491547 |
0 |
3491547 |
7.499 % |
09/02/2022 |
| Wellington Group Holdings LLP |
Delaware |
0 |
2444716 |
0 |
2856986 |
2856986 |
6.14 % |
04/02/2022 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2444716 |
0 |
2856986 |
2856986 |
6.14 % |
04/02/2022 |
| Wellington Group Holdings LLP |
Delaware |
0 |
2444716 |
0 |
2856986 |
2856986 |
6.14 % |
04/02/2022 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2444716 |
0 |
2856986 |
2856986 |
6.14 % |
04/02/2022 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2444716 |
0 |
2856986 |
2856986 |
6.14 % |
04/02/2022 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2444716 |
0 |
2856986 |
2856986 |
6.14 % |
04/02/2022 |
| BANK OF AMERICA CORP /DE/560906609 |
Delaware |
0 |
2672436 |
0 |
2673436 |
2673436 |
5.7 % |
31/01/2022 |
| Morgan Stanley |
Delaware. |
|
2295551 |
0 |
2321595 |
2321595 |
5 % |
12/05/2021 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
3778752 |
0 |
3778752 |
8.185 % |
10/05/2021 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
3778752 |
0 |
3778752 |
8.185 % |
10/05/2021 |
| FMR LLC |
Delaware |
760098 |
0 |
3778752 |
0 |
3778752 |
8.185 % |
10/05/2021 |
| FMR LLC |
Delaware |
760098 |
0 |
3778752 |
0 |
3778752 |
8.185 % |
10/05/2021 |
| Mr. Ortav Yehudai |
USA |
0 |
799722 |
0 |
799722 |
0 |
1.75 % |
16/02/2021 |
| Great Point Partners, LLC |
USA |
0 |
799722 |
0 |
799722 |
0 |
1.75 % |
16/02/2021 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
799722 |
0 |
799722 |
0 |
1.75 % |
16/02/2021 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
799722 |
0 |
799722 |
0 |
1.75 % |
16/02/2021 |
| Great Point Partners, LLC |
USA |
0 |
799722 |
0 |
799722 |
0 |
1.75 % |
16/02/2021 |
| Mr. Ortav Yehudai |
USA |
0 |
799722 |
0 |
799722 |
0 |
1.75 % |
16/02/2021 |
| Baker Bros. Advisors LP |
Delaware |
4909810 |
0 |
4909810 |
0 |
4909810 |
9.99 % |
05/02/2021 |
| Felix J. Baker |
United States |
4909810 |
0 |
4909810 |
0 |
4909810 |
9.99 % |
05/02/2021 |
| Baker Bros. Advisors LP |
Delaware |
4909810 |
0 |
4909810 |
0 |
4909810 |
9.99 % |
05/02/2021 |
| Julian C. Baker |
United States |
4909810 |
0 |
4909810 |
0 |
4909810 |
9.99 % |
05/02/2021 |
| Baker Bros. Advisors |
Delaware |
4909810 |
0 |
4909810 |
0 |
4909810 |
9.99 % |
05/02/2021 |
| Julian C. Baker |
United States |
4909810 |
0 |
4909810 |
0 |
4909810 |
9.99 % |
05/02/2021 |
| Baker Bros. Advisors |
Delaware |
4909810 |
0 |
4909810 |
0 |
4909810 |
9.99 % |
05/02/2021 |
| Felix J. Baker |
United States |
4909810 |
0 |
4909810 |
0 |
4909810 |
9.99 % |
05/02/2021 |
| FMR LLC |
Delaware |
3553131 |
0 |
6798255 |
0 |
6798255 |
14.899 % |
10/11/2020 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
6798255 |
0 |
6798255 |
14.899 % |
10/11/2020 |
| FMR LLC |
Delaware |
3553131 |
0 |
6798255 |
0 |
6798255 |
14.899 % |
10/11/2020 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
6798255 |
0 |
6798255 |
14.899 % |
10/11/2020 |
| Hound Partners, LLC |
Delaware |
0 |
6843595 |
0 |
6843595 |
6843595 |
6.5 % |
22/10/2020 |
| Hound Partners Offshore Fund, LP. |
Cayman Islands |
0 |
6064423 |
0 |
6064423 |
6064423 |
5.76 % |
22/10/2020 |
| Jonathan Auerbach |
United States |
0 |
6843595 |
0 |
6843595 |
6843595 |
6.5 % |
22/10/2020 |
| Hound Performance, LLC |
Delaware |
0 |
6064423 |
0 |
6064423 |
6064423 |
5.76 % |
22/10/2020 |
| Great Point Partners, LLC |
USA |
0 |
2223789 |
0 |
2223789 |
0 |
5.36 % |
14/02/2020 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2223789 |
0 |
2223789 |
0 |
5.36 % |
14/02/2020 |
| Great Point Partners, LLC |
USA |
0 |
2223789 |
0 |
2223789 |
0 |
5.36 % |
14/02/2020 |
| Mr. David Kroin |
USA |
0 |
2223789 |
0 |
2223789 |
0 |
5.36 % |
14/02/2020 |
| Mr. David Kroin |
USA |
0 |
2223789 |
0 |
2223789 |
0 |
5.36 % |
14/02/2020 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2223789 |
0 |
2223789 |
0 |
5.36 % |
14/02/2020 |
| Perceptive Life Sciences Master Fund, Ltd. |
Cayman Islands |
0 |
2403026 |
0 |
2403026 |
2403026 |
6.1 % |
14/02/2020 |
| Perceptive Advisors LLC |
Delaware |
0 |
2403026 |
0 |
2403026 |
2403026 |
6.1 % |
14/02/2020 |
| Joseph Edelman |
United States of America |
0 |
2403026 |
0 |
2403026 |
2403026 |
6.1 % |
14/02/2020 |
| Great Point Partners, LLC |
USA |
0 |
2223789 |
0 |
2223789 |
0 |
5.36 % |
14/02/2020 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2223789 |
0 |
2223789 |
0 |
5.36 % |
14/02/2020 |
| Mr. David Kroin |
USA |
0 |
2223789 |
0 |
2223789 |
0 |
5.36 % |
14/02/2020 |
| Julian C. Baker |
United States |
4181872 |
0 |
4181872 |
0 |
4181872 |
9.99 % |
14/02/2020 |
| Felix J. Baker |
United States |
4181872 |
0 |
4181872 |
0 |
4181872 |
9.99 % |
14/02/2020 |
| Baker Bros. Advisors |
Delaware |
4181872 |
0 |
4181872 |
0 |
4181872 |
9.99 % |
14/02/2020 |
| Baker Bros. Advisors LP |
Delaware |
4181872 |
0 |
4181872 |
0 |
4181872 |
9.99 % |
14/02/2020 |
| Julian C. Baker |
United States |
4181872 |
0 |
4181872 |
0 |
4181872 |
9.99 % |
14/02/2020 |
| Felix J. Baker |
United States |
4181872 |
0 |
4181872 |
0 |
4181872 |
9.99 % |
14/02/2020 |
| Baker Bros. Advisors |
Delaware |
4181872 |
0 |
4181872 |
0 |
4181872 |
9.99 % |
14/02/2020 |
| Baker Bros. Advisors LP |
Delaware |
4181872 |
0 |
4181872 |
0 |
4181872 |
9.99 % |
14/02/2020 |
| Stephen DuBois Not applicable |
Stephen DuBois x United States xAxAxA |
0 |
0 |
0 |
0 |
2013 |
0 % |
14/02/2020 |
| Camber Capital Management LP |
Delaware xAxAxA |
0 |
0 |
0 |
0 |
2013 |
0 % |
14/02/2020 |
| OR Fonds de solidarité des travailleurs du Québec |
Montreal Quebec Canada |
1006738 |
0 |
1006738 |
0 |
1006738 |
2.6 % |
11/02/2020 |
| Celgene Alpine Investment Co., LLC |
Delaware USA |
0 |
1539483 |
0 |
1539483 |
1539483 |
3.9 % |
10/02/2020 |
| Celgene Corporation |
Delaware USA |
0 |
1539483 |
0 |
1539483 |
1539483 |
3.9 % |
10/02/2020 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2954050 |
0 |
2954050 |
7.499 % |
07/02/2020 |
| FMR LLC |
Delaware |
154900 |
0 |
2954050 |
0 |
2954050 |
7.499 % |
07/02/2020 |
| FMR LLC |
Delaware |
154900 |
0 |
2954050 |
0 |
2954050 |
7.499 % |
07/02/2020 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2954050 |
0 |
2954050 |
7.499 % |
07/02/2020 |
| Mr. David Kroin |
USA |
0 |
2082799 |
0 |
2082799 |
2082799 |
5.31 % |
09/08/2019 |
| Great Point Partners, LLC |
USA |
0 |
2082799 |
0 |
2082799 |
2082799 |
5.31 % |
09/08/2019 |
| Mr. David Kroin |
USA |
0 |
2082799 |
0 |
2082799 |
2082799 |
5.31 % |
09/08/2019 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2082799 |
0 |
2082799 |
2082799 |
5.31 % |
09/08/2019 |
| Great Point Partners, LLC |
USA |
0 |
2082799 |
0 |
2082799 |
2082799 |
5.31 % |
09/08/2019 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
2082799 |
0 |
2082799 |
2082799 |
5.31 % |
09/08/2019 |
| Perceptive Life Sciences Master Fund, Ltd. |
Cayman Islands |
0 |
2349147 |
0 |
2349147 |
2349147 |
6 % |
02/07/2019 |
| Joseph Edelman |
United States of America |
0 |
2349147 |
0 |
2349147 |
2349147 |
6 % |
02/07/2019 |
| Perceptive Advisors LLC |
Delaware |
0 |
2349147 |
0 |
2349147 |
2349147 |
6 % |
02/07/2019 |
| CTI Partners, L.P. |
Quebec, Canada |
979540 |
0 |
979540 |
0 |
979540 |
3.06 % |
29/05/2019 |
| CTI Life Sciences Fund II, L.P. |
Quebec, Canada |
0 |
0 |
0 |
0 |
76923 |
0.24 % |
29/05/2019 |
| CTI Partners II, L.P. |
Quebec, Canada |
76923 |
0 |
76923 |
0 |
76923 |
0.24 % |
29/05/2019 |
| CTI Life Sciences Fund, L.P. |
Quebec, Canada |
0 |
0 |
0 |
0 |
979540 |
3.06 % |
29/05/2019 |
| OR |
Montreal (Quebec) Canada |
1756738 |
0 |
1756738 |
0 |
1756738 |
5.5 % |
10/05/2019 |
| OR |
Montreal (Quebec) Canada |
1756738 |
0 |
1756738 |
0 |
1756738 |
5.5 % |
10/05/2019 |
| CTI Partners II, L.P. |
Quebec, Canada |
76923 |
0 |
76923 |
0 |
76923 |
0.24 % |
14/02/2019 |
| CTI Life Sciences Fund II, L.P. |
Quebec, Canada |
0 |
0 |
0 |
0 |
76923 |
0.24 % |
14/02/2019 |
| CTI Partners, L.P. |
Quebec, Canada |
1809415 |
0 |
1809415 |
0 |
1809415 |
5.65 % |
14/02/2019 |
| CTI Life Sciences Fund, L.P. |
Quebec, Canada |
0 |
0 |
0 |
0 |
1809415 |
5.65 % |
14/02/2019 |
| Baker Bros. Advisors LLC |
Delaware |
1708472 |
0 |
1708472 |
0 |
1708472 |
5.3 % |
13/02/2019 |
| Felix J. Baker |
United States |
1708472 |
0 |
1708472 |
0 |
1708472 |
5.3 % |
13/02/2019 |
| Julian C. Baker |
United States |
1708472 |
0 |
1708472 |
0 |
1708472 |
5.3 % |
13/02/2019 |
| Baker Bros. Advisors LP |
Delaware |
1708472 |
0 |
1708472 |
0 |
1708472 |
5.3 % |
13/02/2019 |
| OR |
Montreal (Quebec) Canada |
1551787 |
0 |
1551787 |
0 |
1551787 |
4.85 % |
11/02/2019 |
| Stephen DuBois Not applicable |
Stephen DuBois – United States |
0 |
2166000 |
0 |
2166000 |
2166000 |
6.78 % |
14/11/2018 |
| Camber Capital Management LP |
Delaware |
0 |
2166000 |
0 |
2166000 |
2166000 |
6.78 % |
14/11/2018 |
| Camber Capital Management LP |
Delaware |
0 |
2166000 |
0 |
2166000 |
2166000 |
6.78 % |
14/11/2018 |
| Stephen DuBois Not applicable |
Stephen DuBois – United States |
0 |
2166000 |
0 |
2166000 |
2166000 |
6.78 % |
14/11/2018 |
| CTI Partners II, L.P. |
Quebec Canada |
76923 |
0 |
76923 |
0 |
76923 |
0.31 % |
13/07/2018 |
| CTI Partners, L.P. |
Quebec Canada |
2950979 |
0 |
2950979 |
0 |
2950979 |
11.84 % |
13/07/2018 |
| CTI Life Sciences Fund II, L.P. |
Quebec Canada |
0 |
0 |
0 |
0 |
76923 |
0.31 % |
13/07/2018 |
| CTI Life Sciences Fund, L.P. |
Quebec Canada |
0 |
0 |
0 |
0 |
2950979 |
11.84 % |
13/07/2018 |
| BDC Capital Inc. |
Canadian |
1923074 |
0 |
1923074 |
0 |
1923074 |
7.58 % |
13/02/2018 |
| OR |
Montreal (Quebec) Canada |
1551787 |
0 |
1551787 |
0 |
1551787 |
6.1 % |
08/02/2018 |
| OR |
Montreal (Quebec) Canada |
1303187 |
0 |
1303187 |
0 |
1303187 |
5.2 % |
11/05/2017 |
| OR |
Montreal (Quebec) Canada |
1303187 |
0 |
1303187 |
0 |
1303187 |
5.2 % |
11/05/2017 |
| Celgene Corporation |
Delaware, U.S.A. |
0 |
1539483 |
0 |
1539483 |
1539483 |
6.2 % |
05/05/2017 |
| Celgene Alpine Investment Co., LLC |
Delaware, U.S.A. |
0 |
1539483 |
0 |
1539483 |
1539483 |
6.2 % |
05/05/2017 |