| Abigail P. Johnson |
Delaware |
0 |
0 |
234718 |
0 |
234718 |
1.128 % |
12/11/2024 |
| FMR LLC |
Delaware |
233571 |
0 |
234718 |
0 |
234718 |
1.128 % |
12/11/2024 |
| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
1473116 |
0 |
1490709 |
7.2 % |
08/11/2024 |
| Augustus Stern, MD |
USA |
1116628 |
0 |
1116628 |
0 |
1116628 |
5.37 % |
30/10/2024 |
| Augustus Stern, MD |
USA |
1116628 |
0 |
1116628 |
0 |
1116628 |
5.37 % |
30/10/2024 |
| 27-1545452 |
|
0 |
0 |
0 |
0 |
1055103 |
5.07 % |
23/10/2024 |
| 27-1545452 |
California, United States of America |
13665 |
0 |
1055103 |
0 |
1055103 |
5.07 % |
23/10/2024 |
| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
0 |
0 |
1490709 |
7.2 % |
22/10/2024 |
| Logos Global Master Fund LP |
Delaware |
0 |
10833334 |
0 |
0 |
10833334 |
11 % |
22/02/2024 |
| Logos Global Management GP LLC |
Delaware |
0 |
15000000 |
0 |
0 |
15000000 |
11 % |
22/02/2024 |
| Logos GP LLC |
Delaware |
0 |
10833334 |
0 |
0 |
10833334 |
11 % |
22/02/2024 |
| Logos Global Management LP |
Delaware |
0 |
15000000 |
0 |
0 |
15000000 |
11 % |
22/02/2024 |
| Logos Global Management GP LLC |
Delaware |
0 |
15000000 |
0 |
0 |
15000000 |
11 % |
22/02/2024 |
| Logos GP LLC |
Delaware |
0 |
10833334 |
0 |
0 |
10833334 |
11 % |
22/02/2024 |
| Logos Global Master Fund LP |
Delaware |
0 |
10833334 |
0 |
0 |
10833334 |
11 % |
22/02/2024 |
| Arsani William |
Delaware |
0 |
15000000 |
0 |
0 |
15000000 |
11 % |
22/02/2024 |
| Logos Global Management LP |
Delaware |
0 |
15000000 |
0 |
0 |
15000000 |
11 % |
22/02/2024 |
| Arsani William |
Delaware |
0 |
15000000 |
0 |
0 |
15000000 |
11 % |
22/02/2024 |
| Chen Yu |
Delaware |
0 |
20763572 |
0 |
20763572 |
20763572 |
9.9 % |
15/02/2024 |
| TCG Crossover GP II, LLC |
Delaware |
0 |
20763572 |
0 |
20763572 |
20763572 |
9.9 % |
15/02/2024 |
| Chen Yu |
Delaware |
0 |
20763572 |
0 |
20763572 |
20763572 |
9.9 % |
15/02/2024 |
| TCG Crossover GP II, LLC |
Delaware |
0 |
20763572 |
0 |
20763572 |
20763572 |
9.9 % |
15/02/2024 |
| TCG Crossover Fund II, L.P. |
Delaware |
0 |
20763572 |
0 |
20763572 |
20763572 |
9.9 % |
15/02/2024 |
| TCG Crossover Fund II, L.P. |
Delaware |
0 |
20763572 |
0 |
20763572 |
20763572 |
9.9 % |
15/02/2024 |
| Opportunity Fund Holdings, L.P. |
Delaware |
15000000 |
0 |
15000000 |
0 |
15000000 |
7.2 % |
14/02/2024 |
| Vivo Opportunity, LLC |
Delaware |
15000000 |
0 |
15000000 |
0 |
15000000 |
7.2 % |
14/02/2024 |
| Opportunity Fund Holdings, L.P. |
Delaware |
15000000 |
0 |
15000000 |
0 |
15000000 |
7.2 % |
14/02/2024 |
| Vivo Opportunity, LLC |
Delaware |
15000000 |
0 |
15000000 |
0 |
15000000 |
7.2 % |
14/02/2024 |
| FHMLSP Overage, L.P. |
Delaware |
0 |
2395833 |
0 |
2395833 |
2395833 |
1.2 % |
09/02/2024 |
| FHMLSP Overage, L.L.C. |
Delaware |
0 |
2395833 |
0 |
2395833 |
2395833 |
1.2 % |
09/02/2024 |
| Frazier Life Sciences Public Fund, L.P. |
Delaware |
0 |
5003125 |
0 |
5003125 |
5003125 |
2.4 % |
09/02/2024 |
| FHMLSP, L.L.C. |
Delaware |
0 |
5003125 |
0 |
5003125 |
5003125 |
2.4 % |
09/02/2024 |
| Frazier Life Sciences Public Fund, L.P. |
Delaware |
0 |
5003125 |
0 |
5003125 |
5003125 |
2.4 % |
09/02/2024 |
| Frazier Life Sciences X, L.P. |
Delaware |
0 |
1017708 |
0 |
1017708 |
1017708 |
0.5 % |
09/02/2024 |
| FHMLSP, L.L.C. |
Delaware |
0 |
5003125 |
0 |
5003125 |
5003125 |
2.4 % |
09/02/2024 |
| Daniel Estes |
Delaware |
0 |
2000000 |
0 |
2000000 |
2000000 |
1 % |
09/02/2024 |
| James Brush |
Delaware |
0 |
7398958 |
0 |
7398958 |
7398958 |
3.6 % |
09/02/2024 |
| James N. Topper |
Delaware |
0 |
10416666 |
0 |
10416666 |
10416666 |
5 % |
09/02/2024 |
| FHMLS XI, L.L.C. |
Delaware |
0 |
2000000 |
0 |
2000000 |
2000000 |
1 % |
09/02/2024 |
| FHMLS XI, L.P. |
Delaware |
0 |
2000000 |
0 |
2000000 |
2000000 |
1 % |
09/02/2024 |
| FHMLS X, L.L.C. |
Delaware |
0 |
1017708 |
0 |
1017708 |
1017708 |
0.5 % |
09/02/2024 |
| James N. Topper |
Delaware |
0 |
10416666 |
0 |
10416666 |
10416666 |
5 % |
09/02/2024 |
| Patrick J. Heron |
Delaware |
0 |
10416666 |
0 |
10416666 |
10416666 |
5 % |
09/02/2024 |
| Frazier Life Sciences XI, L.P. |
Delaware |
0 |
2000000 |
0 |
2000000 |
2000000 |
1 % |
09/02/2024 |
| FHMLS X, L.P. |
Delaware |
0 |
1017708 |
0 |
1017708 |
1017708 |
0.5 % |
09/02/2024 |
| Frazier Life Sciences X, L.P. |
Delaware |
0 |
1017708 |
0 |
1017708 |
1017708 |
0.5 % |
09/02/2024 |
| FHMLSP Overage, L.P. |
Delaware |
0 |
2395833 |
0 |
2395833 |
2395833 |
1.2 % |
09/02/2024 |
| Frazier Life Sciences Public Overage Fund, L.P. |
Delaware |
0 |
2395833 |
0 |
2395833 |
2395833 |
1.2 % |
09/02/2024 |
| FHMLSP, L.P. |
Delaware |
0 |
5003125 |
0 |
5003125 |
5003125 |
2.4 % |
09/02/2024 |
| FHMLSP, L.P. |
Delaware |
0 |
5003125 |
0 |
5003125 |
5003125 |
2.4 % |
09/02/2024 |
| Frazier Life Sciences Public Overage Fund, L.P. |
Delaware |
0 |
2395833 |
0 |
2395833 |
2395833 |
1.2 % |
09/02/2024 |
| FHMLSP Overage, L.L.C. |
Delaware |
0 |
2395833 |
0 |
2395833 |
2395833 |
1.2 % |
09/02/2024 |
| FHMLS X, L.P. |
Delaware |
0 |
1017708 |
0 |
1017708 |
1017708 |
0.5 % |
09/02/2024 |
| FHMLS X, L.L.C. |
Delaware |
0 |
1017708 |
0 |
1017708 |
1017708 |
0.5 % |
09/02/2024 |
| Frazier Life Sciences XI, L.P. |
Delaware |
0 |
2000000 |
0 |
2000000 |
2000000 |
1 % |
09/02/2024 |
| FHMLS XI, L.P. |
Delaware |
0 |
2000000 |
0 |
2000000 |
2000000 |
1 % |
09/02/2024 |
| FHMLS XI, L.L.C. |
Delaware |
0 |
2000000 |
0 |
2000000 |
2000000 |
1 % |
09/02/2024 |
| Patrick J. Heron |
Delaware |
0 |
10416666 |
0 |
10416666 |
10416666 |
5 % |
09/02/2024 |
| Albert Cha |
Delaware |
0 |
7398958 |
0 |
7398958 |
7398958 |
3.6 % |
09/02/2024 |
| James Brush |
Delaware |
0 |
7398958 |
0 |
7398958 |
7398958 |
3.6 % |
09/02/2024 |
| Daniel Estes |
Delaware |
0 |
2000000 |
0 |
2000000 |
2000000 |
1 % |
09/02/2024 |
| Albert Cha |
Delaware |
0 |
7398958 |
0 |
7398958 |
7398958 |
3.6 % |
09/02/2024 |
| VHCP Management III, LLC |
Delaware |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| VHCP Co-Investment Holdings III, LLC |
Delaware |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| Venrock Healthcare Capital Partners EG, L.P. |
Delaware |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| Koh, Bong |
United States |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| VHCP Co-Investment Holdings III, LLC |
Delaware |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| Shah, Nimish |
United States |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| VHCP Management III, LLC |
Delaware |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| Venrock Healthcare Capital Partners III, L.P. |
Delaware |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| Venrock Healthcare Capital Partners EG, L.P. |
Delaware |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| VHCP Management EG, LLC |
Delaware |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| Koh, Bong |
Delaware |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| Shah, Nimish |
Delaware |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| VHCP Management EG, LLC |
Delaware |
0 |
5899489 |
0 |
0 |
5899489 |
5.9 % |
24/07/2023 |
| Capital LP |
USA |
0 |
6158141 |
0 |
6158141 |
6158141 |
6.1 % |
20/04/2023 |
| Capital Master LP |
Islands |
0 |
6158141 |
0 |
6158141 |
6158141 |
6.1 % |
20/04/2023 |
| Capital Master LP |
Delaware, USA |
0 |
6158141 |
0 |
6158141 |
6158141 |
6.1 % |
20/04/2023 |
| Capital LP |
Delaware, USA |
0 |
6158141 |
0 |
6158141 |
6158141 |
6.1 % |
20/04/2023 |
| BANK OF AMERICA CORPORATION56-0906609 |
Delaware |
0 |
5587896 |
0 |
5591896 |
5591896 |
5.6 % |
14/02/2023 |
| Morgan Stanley Capital Services LLC |
Delaware. |
0 |
0 |
0 |
13 |
7129709 |
7.1 % |
08/02/2023 |
| Morgan Stanley |
Delaware. |
0 |
7133802 |
0 |
13 |
7135052 |
7.2 % |
08/02/2023 |
| Levy |
Cayman Islands |
0 |
4982789 |
0 |
4982789 |
4982789 |
5 % |
02/09/2022 |
| Master Fund, L.P. |
Cayman Islands |
0 |
4982789 |
0 |
4982789 |
4982789 |
5 % |
02/09/2022 |
| Master Fund, L.P. |
Delaware |
0 |
4982789 |
0 |
4982789 |
4982789 |
5 % |
02/09/2022 |
| Group, LLC |
Cayman Islands |
0 |
4982789 |
0 |
4982789 |
4982789 |
5 % |
02/09/2022 |
| LLC |
Cayman Islands |
0 |
4982789 |
0 |
4982789 |
4982789 |
5 % |
02/09/2022 |
| LLC |
Delaware |
0 |
4982789 |
0 |
4982789 |
4982789 |
5 % |
02/09/2022 |
| Levy |
Delaware |
0 |
4982789 |
0 |
4982789 |
4982789 |
5 % |
02/09/2022 |
| Group, LLC |
Delaware |
0 |
4982789 |
0 |
4982789 |
4982789 |
5 % |
02/09/2022 |
| (1) BlackRock, Inc. |
Delaware |
3246012 |
0 |
3323843 |
0 |
3323843 |
3.4 % |
08/07/2022 |
| BML Investment Partners, L.P. |
Delaware |
0 |
4950000 |
0 |
4950000 |
4950000 |
5 % |
10/05/2022 |
| BML Investment Partners, L.P. |
Delaware |
0 |
4950000 |
0 |
4950000 |
4950000 |
5 % |
10/05/2022 |
| Braden M Leonard |
Delaware |
225500 |
4950000 |
225500 |
4950000 |
5175500 |
5.2 % |
10/05/2022 |
| Braden M Leonard |
Delaware |
225500 |
4950000 |
225500 |
4950000 |
5175500 |
5.2 % |
10/05/2022 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
10873853 |
0 |
10873853 |
11.011 % |
11/04/2022 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
10873853 |
0 |
10873853 |
11.011 % |
11/04/2022 |
| FMR LLC |
Delaware |
10871458 |
0 |
10873853 |
0 |
10873853 |
11.011 % |
11/04/2022 |
| FMR LLC |
Delaware |
10871458 |
0 |
10873853 |
0 |
10873853 |
11.011 % |
11/04/2022 |
| RTW Investments, LP |
Delaware |
0 |
7554817 |
0 |
0 |
7554817 |
7.7 % |
14/02/2022 |
| Roderick Wong |
United States |
0 |
7554817 |
0 |
0 |
7554817 |
7.7 % |
14/02/2022 |
| OrbiMed Advisors LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| OrbiMed Advisors LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| OrbiMed Capital LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| OrbiMed Capital LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
11/02/2022 |
| REGENERON PHARMACEUTICALS, INC. |
|
1809098 |
0 |
1809098 |
0 |
1809098 |
1.84 % |
11/02/2022 |
| Avoro Capital Advisors LLC |
Delaware |
6950000 |
0 |
6950000 |
0 |
6950000 |
7.1 % |
11/02/2022 |
| Behzad Aghazadeh |
United States |
6950000 |
0 |
6950000 |
0 |
6950000 |
7.1 % |
11/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
7167657 |
0 |
7346822 |
0 |
7346822 |
7.5 % |
03/02/2022 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
1884253 |
0 |
2047619 |
2047619 |
2.09 % |
12/10/2021 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
10047490 |
0 |
10210856 |
10210856 |
10.41 % |
10/09/2021 |
| RA Capital Management, L.P. |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
16/08/2021 |
| RA Capital Management, L.P. |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
16/08/2021 |
| The Sonic Fund II, L.P. |
Delaware |
0 |
6052068 |
0 |
10 |
6052068 |
6.2 % |
18/03/2021 |
| Lawrence Kam |
United States |
57984 |
6073448 |
57984 |
10 |
6131432 |
6.3 % |
18/03/2021 |
| The Sonic Fund II, L.P. |
|
0 |
6052068 |
0 |
11 |
6052068 |
6.2 % |
18/03/2021 |
| Lawrence Kam |
|
57984 |
6073448 |
57984 |
11 |
6131432 |
6.3 % |
18/03/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
9502383 |
0 |
9502383 |
9502383 |
9.7 % |
16/02/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
9502383 |
0 |
9502383 |
9502383 |
9.7 % |
16/02/2021 |
| LAWRENCE KAM |
DELAWARE |
0 |
0 |
92984 |
5123167 |
5216151 |
5.4 % |
16/02/2021 |
| THE SONIC FUND II, L.P. |
DELAWARE |
0 |
0 |
0 |
5101787 |
5101787 |
5.2 % |
16/02/2021 |
| THE SONIC FUND II, L.P. |
DELAWARE |
0 |
0 |
0 |
5101787 |
5101787 |
5.2 % |
16/02/2021 |
| LAWRENCE KAM |
DELAWARE |
0 |
0 |
92984 |
5123167 |
5216151 |
5.4 % |
16/02/2021 |
| OrbiMed Capital LLC |
Delaware |
4845247 |
0 |
4845247 |
0 |
4845247 |
4.97 % |
12/02/2021 |
| OrbiMed Advisors LLC |
Delaware |
0 |
655897 |
0 |
0 |
655897 |
0.67 % |
12/02/2021 |
| RTW
Investments, LP |
OR PLACE OF ORGANIZATION |
0 |
7227364 |
0 |
7227364 |
7227364 |
7.42 % |
12/02/2021 |
| Roderick
Wong |
OR PLACE OF ORGANIZATION |
0 |
7227364 |
0 |
7227364 |
7227364 |
7.42 % |
12/02/2021 |
| RTW
Master Fund, Ltd. |
OR PLACE OF ORGANIZATION |
0 |
5518874 |
0 |
5518874 |
5518874 |
5.66 % |
12/02/2021 |
| Avoro Capital Advisors LLC |
Delaware |
8000000 |
0 |
8000000 |
0 |
8000000 |
8.2 % |
12/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
6954131 |
0 |
7042768 |
0 |
7042768 |
7.2 % |
28/01/2021 |
| S |
|
0 |
6386607 |
0 |
0 |
6386607 |
9.89 % |
14/02/2020 |
| Investments, LP |
|
0 |
6386607 |
0 |
0 |
6386607 |
9.89 % |
14/02/2020 |
| S |
|
0 |
5236550 |
0 |
0 |
5236550 |
8.11 % |
14/02/2020 |
| OrbiMed Capital LLC |
Delaware |
0 |
3944090 |
0 |
0 |
3944090 |
6.11 % |
14/02/2020 |
| Advisors LLC |
Delaware |
0 |
398100 |
0 |
0 |
398100 |
0.62 % |
14/02/2020 |
| OrbiMed Capital LLC |
Delaware |
0 |
3944090 |
0 |
0 |
3944090 |
6.11 % |
14/02/2020 |
| Advisors LLC |
Delaware |
0 |
398100 |
0 |
0 |
398100 |
0.62 % |
14/02/2020 |
| Behzad Aghazadeh |
|
5250000 |
0 |
5250000 |
0 |
5250000 |
8.1 % |
14/02/2020 |
| Avoro Capital Advisors LLC |
|
5250000 |
0 |
5250000 |
0 |
5250000 |
8.1 % |
14/02/2020 |
| Behzad Aghazadeh |
United States |
5250000 |
0 |
5250000 |
0 |
5250000 |
8.1 % |
14/02/2020 |
| Avoro Capital Advisors LLC |
Delaware |
5250000 |
0 |
5250000 |
0 |
5250000 |
8.1 % |
14/02/2020 |
| 13-3127734 |
Delaware |
1455848 |
0 |
1455848 |
0 |
1455848 |
2.25 % |
13/02/2020 |
| 26-0385758 |
Delaware |
1455848 |
0 |
1455848 |
0 |
1455848 |
2.25 % |
13/02/2020 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
1000000 |
0 |
0 |
1000000 |
1.55 % |
12/02/2020 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
1000000 |
0 |
0 |
1000000 |
1.55 % |
12/02/2020 |
| Robert Atchinson |
United States |
0 |
1000000 |
0 |
0 |
1000000 |
1.55 % |
12/02/2020 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
1000000 |
0 |
0 |
1000000 |
1.55 % |
12/02/2020 |
| Phillip Gross |
United States |
0 |
1000000 |
0 |
0 |
1000000 |
1.55 % |
12/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
4411565 |
0 |
4518433 |
0 |
4518433 |
7 % |
05/02/2020 |
| Phillip Gross |
United States |
0 |
3500000 |
0 |
0 |
3500000 |
5.52 % |
30/05/2019 |
| Robert Atchinson |
Delaware |
0 |
3500000 |
0 |
0 |
3500000 |
5.52 % |
30/05/2019 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
3500000 |
0 |
0 |
3500000 |
5.52 % |
30/05/2019 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
3500000 |
0 |
0 |
3500000 |
5.52 % |
30/05/2019 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
3500000 |
0 |
0 |
3500000 |
5.52 % |
30/05/2019 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
350000 |
0 |
0 |
3500000 |
5.52 % |
30/05/2019 |
| Phillip Gross |
Delaware |
0 |
3500000 |
0 |
0 |
3500000 |
5.52 % |
30/05/2019 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
350000 |
0 |
0 |
3500000 |
5.52 % |
30/05/2019 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
3500000 |
0 |
0 |
3500000 |
5.52 % |
30/05/2019 |
| Robert Atchinson |
United States |
0 |
3500000 |
0 |
0 |
3500000 |
5.52 % |
30/05/2019 |
| Lawrence Kam |
United States |
144304 |
3651262 |
144304 |
10 |
3795566 |
6 % |
03/05/2019 |
| The Sonic Fund II, L.P. |
Delaware |
0 |
3648212 |
0 |
10 |
3648212 |
5.8 % |
03/05/2019 |
| The Sonic Fund II, L.P. |
Delaware |
0 |
3348212 |
0 |
10 |
3348212 |
5.3 % |
21/03/2019 |
| Lawrence Kam |
United States |
144304 |
3351262 |
144304 |
10 |
3495566 |
5.5 % |
21/03/2019 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
3000000 |
0 |
0 |
3000000 |
4.77 % |
13/02/2019 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
3000000 |
0 |
0 |
3000000 |
4.77 % |
13/02/2019 |
| Robert Atchinson |
Delaware |
0 |
3000000 |
0 |
0 |
3000000 |
4.77 % |
13/02/2019 |
| Phillip Gross |
Delaware |
0 |
3000000 |
0 |
0 |
3000000 |
4.77 % |
13/02/2019 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
3000000 |
0 |
0 |
3000000 |
4.77 % |
13/02/2019 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
3000000 |
0 |
0 |
3000000 |
4.77 % |
13/02/2019 |
| Robert Atchinson |
United States |
0 |
3000000 |
0 |
0 |
3000000 |
4.77 % |
13/02/2019 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
3000000 |
0 |
0 |
3000000 |
4.77 % |
13/02/2019 |
| Phillip Gross |
United States |
0 |
3000000 |
0 |
0 |
3000000 |
4.77 % |
13/02/2019 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
3000000 |
0 |
0 |
3000000 |
4.77 % |
13/02/2019 |
| 13-3127734 |
Delaware |
3653000 |
0 |
3662541 |
55226 |
3717767 |
5.91 % |
12/02/2019 |
| 13-3127734 |
Delaware |
3653000 |
0 |
3662541 |
55226 |
3717767 |
5.91 % |
12/02/2019 |
| 26-0385758 |
Delaware |
3653000 |
0 |
3662541 |
55226 |
3717767 |
5.91 % |
12/02/2019 |
| 26-0385758 |
Delaware |
3653000 |
0 |
3662541 |
55226 |
3717767 |
5.91 % |
12/02/2019 |
| (1) BlackRock, Inc. |
Delaware |
4352602 |
0 |
4443970 |
0 |
4443970 |
7.1 % |
07/02/2019 |
| Wong |
States of America |
0 |
3841226 |
0 |
3841226 |
3841226 |
6.1 % |
16/11/2018 |
| Investments, LP |
Cayman Islands |
0 |
3841226 |
0 |
3841226 |
3841226 |
6.1 % |
16/11/2018 |
| Wong |
Cayman Islands |
0 |
3841226 |
0 |
3841226 |
3841226 |
6.1 % |
16/11/2018 |
| Investments, LP |
United States of America |
0 |
3841226 |
0 |
3841226 |
3841226 |
6.1 % |
16/11/2018 |
| Master Fund, Ltd. |
Islands |
0 |
3215239 |
0 |
3215239 |
3215239 |
5.1 % |
16/11/2018 |
| Master Fund, Ltd. |
Cayman Islands |
0 |
3215239 |
0 |
3215239 |
3215239 |
5.1 % |
16/11/2018 |
| MSF International Ltd. |
State of Delaware |
0 |
2700000 |
0 |
0 |
2700000 |
5.99 % |
14/02/2018 |
| Capital Management, LLC |
State of Delaware |
0 |
2700000 |
0 |
0 |
2700000 |
5.99 % |
14/02/2018 |
| Capital Management, LLC |
State of Delaware |
0 |
2700000 |
0 |
0 |
2700000 |
5.99 % |
14/02/2018 |
| MSF International Ltd. |
State of Delaware |
0 |
2700000 |
0 |
0 |
2700000 |
5.99 % |
14/02/2018 |
| 26-0385758 |
Delaware |
1974200 |
0 |
2247138 |
307539 |
2554677 |
5.67 % |
13/02/2018 |
| 13-3127734 |
Delaware |
1974200 |
0 |
2247138 |
307539 |
2554677 |
5.67 % |
13/02/2018 |
| Zygmunt Wilf |
New Jersey |
0 |
1958061 |
0 |
1958061 |
1958061 |
4.3 % |
31/01/2018 |
| Zygtech, LLC |
New Jersey |
0 |
1958061 |
0 |
1958061 |
1958061 |
4.3 % |
31/01/2018 |
| 1992 MSF International Ltd. |
State of Delaware |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
06/12/2017 |
| 1992 MSF International Ltd. |
State of Delaware |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
06/12/2017 |
| Highbridge Capital Management, LLC |
State of Delaware |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
06/12/2017 |
| Highbridge Capital Management, LLC |
State of Delaware |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
06/12/2017 |
| Robert Atchinson |
United States |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
27/11/2017 |
| Robert Atchinson |
United States |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
27/11/2017 |
| Adage Capital Advisors, L.L.C. |
United States |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
27/11/2017 |
| Adage Capital Partners, L.P. |
United States |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
27/11/2017 |
| Adage Capital Partners GP, L.L.C. |
United States |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
27/11/2017 |
| Adage Capital Advisors, L.L.C. |
United States |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
27/11/2017 |
| Phillip Gross |
United States |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
27/11/2017 |
| Phillip Gross |
United States |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
27/11/2017 |
| Adage Capital Partners, L.P. |
United States |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
27/11/2017 |
| Adage Capital Partners GP, L.L.C. |
United States |
0 |
2500000 |
0 |
0 |
2500000 |
5.55 % |
27/11/2017 |
| Bpifrance Participations S.A. |
France |
0 |
2640775 |
0 |
0 |
2640775 |
6.3 % |
11/05/2017 |
| Caisse des Dépôts et Consignations |
France |
0 |
2640775 |
0 |
0 |
2640775 |
6.3 % |
11/05/2017 |
| Bpifrance S.A. |
France |
0 |
2640775 |
0 |
0 |
2640775 |
6.3 % |
11/05/2017 |
| EPIC Bpifrance |
France |
0 |
2640775 |
0 |
0 |
2640775 |
6.3 % |
11/05/2017 |
| Fonds Biotechnologies Innovantes et Maladies Rares |
France |
0 |
2640775 |
0 |
0 |
2640775 |
6.3 % |
11/05/2017 |
| Bpifrance Investissement S.A.S. |
France |
0 |
2640775 |
0 |
0 |
2640775 |
6.3 % |
11/05/2017 |
| Numeric Investors LLC |
Delaware |
0 |
1235345 |
0 |
0 |
1235345 |
2.96 % |
09/02/2017 |
| Man Group plc |
Delaware |
0 |
1235345 |
0 |
0 |
1235345 |
2.96 % |
09/02/2017 |
| Zygmunt Wilf |
New Jersey |
0 |
2175279 |
0 |
0 |
2175279 |
5.2 % |
23/01/2017 |
| Zygtech, LLC |
New Jersey |
0 |
2175279 |
0 |
0 |
2175279 |
5.2 % |
23/01/2017 |
| (1) BlackRock, Inc. |
Delaware |
1244586 |
0 |
1269714 |
0 |
1269714 |
4.9 % |
10/03/2016 |
| Deerfield Partners, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
| James E. Flynn |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
| Deerfield Mgmt III, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
| Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
| Deerfield Special Situations International Master Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
| Deerfield International Master Fund, L.P |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2016 |
| Zygtech, LLC |
New Jersey |
0 |
2338176 |
0 |
0 |
2338176 |
9.1 % |
05/02/2016 |
| Zygmunt Wilf |
New Jersey |
0 |
2338176 |
0 |
0 |
2338176 |
9.1 % |
05/02/2016 |
| (1) BlackRock, Inc. |
Delaware |
1296369 |
0 |
1323414 |
0 |
1323414 |
5.1 % |
28/01/2016 |
| Man Group plc |
State of Delaware |
0 |
1375602 |
0 |
0 |
1375602 |
5.34 % |
21/01/2016 |
| Numeric Investors LLC |
State of Delaware |
0 |
1375602 |
0 |
0 |
1375602 |
5.34 % |
21/01/2016 |
| Man Group plc |
State of Delaware |
0 |
1375602 |
0 |
0 |
1375602 |
5.34 % |
21/01/2016 |
| Numeric Investors LLC |
State of Delaware |
0 |
1375602 |
0 |
0 |
1375602 |
5.34 % |
21/01/2016 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
184594 |
0 |
0 |
184594 |
0.82 % |
17/02/2015 |
| Deerfield Mgmt III, L.P. |
Delaware |
0 |
654285 |
0 |
0 |
654285 |
2.91 % |
17/02/2015 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
960384 |
0 |
0 |
960384 |
4.27 % |
17/02/2015 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
1614669 |
0 |
0 |
1614669 |
7.19 % |
17/02/2015 |
| Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
347557 |
0 |
0 |
347557 |
1.55 % |
17/02/2015 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
147410 |
0 |
0 |
147410 |
0.66 % |
17/02/2015 |
| Deerfield Partners, L.P. |
Delaware |
0 |
280823 |
0 |
0 |
280823 |
1.25 % |
17/02/2015 |
| Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
654285 |
0 |
0 |
654285 |
2.91 % |
17/02/2015 |
| James E. Flynn |
United States |
0 |
1614669 |
0 |
0 |
1614669 |
7.19 % |
17/02/2015 |
| x3 |
Delaware |
0 |
13827352 |
0 |
13827352 |
13827352 |
6.2 % |
13/02/2015 |
| x3 |
Delaware |
0 |
13827352 |
0 |
13827352 |
13827352 |
6.2 % |
13/02/2015 |
| x3 |
Delaware |
0 |
13827352 |
0 |
13827352 |
13827352 |
6.2 % |
13/02/2015 |
| x3 |
Delaware |
0 |
13827352 |
0 |
13827352 |
13827352 |
6.2 % |
13/02/2015 |
| x3 |
Delaware |
0 |
13827352 |
0 |
13827352 |
13827352 |
6.2 % |
13/02/2015 |
| 6.2%4 |
Delaware |
0 |
13827352 |
0 |
13827352 |
13827352 |
6.2 % |
13/02/2015 |
| 4.4%4 |
Delaware |
0 |
9827362 |
0 |
9827362 |
9827362 |
4.4 % |
13/02/2015 |
| x3 |
Delaware |
0 |
13827352 |
0 |
13827352 |
13827352 |
6.2 % |
13/02/2015 |
| 6.2%4 |
Delaware |
0 |
13827352 |
0 |
13827352 |
13827352 |
6.2 % |
13/02/2015 |
| 4.4%4 |
Delaware |
0 |
9827362 |
0 |
9827362 |
9827362 |
4.4 % |
13/02/2015 |
| 4.4%4 |
Delaware |
0 |
9827362 |
0 |
9827362 |
9827362 |
4.4 % |
13/02/2015 |
| 4.4%4 |
Delaware |
0 |
9827362 |
0 |
9827362 |
9827362 |
4.4 % |
13/02/2015 |
| Zygtech, LLC |
New Jersey |
0 |
2563176 |
0 |
0 |
2563176 |
11.26 % |
03/02/2015 |
| Zygmunt Wilf |
New Jersey |
0 |
2563176 |
0 |
0 |
2563176 |
11.26 % |
03/02/2015 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
3370545 |
0 |
3370545 |
15 % |
10/12/2014 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
3370545 |
0 |
3370545 |
15 % |
10/12/2014 |
| FMR LLC |
Delaware |
153704 |
0 |
3370545 |
0 |
3370545 |
15 % |
10/12/2014 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
3370545 |
0 |
3370545 |
15 % |
10/12/2014 |
| FMR LLC |
Delaware |
153704 |
0 |
3370545 |
0 |
3370545 |
15 % |
10/12/2014 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
3370545 |
0 |
3370545 |
15 % |
10/12/2014 |
| 8.1%* |
New York |
0 |
0 |
0 |
0 |
1809098 |
8.1 % |
07/08/2014 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
227294 |
0 |
0 |
227294 |
1.02 % |
05/08/2014 |
| Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
654285 |
0 |
0 |
654285 |
2.94 % |
05/08/2014 |
| Deerfield Partners, L.P. |
Delaware |
0 |
507200 |
0 |
0 |
507200 |
2.28 % |
05/08/2014 |
| James E. Flynn |
Delaware |
0 |
2197679 |
0 |
0 |
2197679 |
9.87 % |
05/08/2014 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
1543394 |
0 |
0 |
1543394 |
6.93 % |
05/08/2014 |
| Deerfield Mgmt III, L.P. |
Delaware |
0 |
654285 |
0 |
0 |
654285 |
2.94 % |
05/08/2014 |
| Deerfield Private Design Fund III, L.P. |
Delaware |
0 |
654285 |
0 |
0 |
654285 |
2.94 % |
05/08/2014 |
| Deerfield Partners, L.P. |
Delaware |
0 |
507200 |
0 |
0 |
507200 |
2.28 % |
05/08/2014 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
1543394 |
0 |
0 |
1543394 |
6.93 % |
05/08/2014 |
| James E. Flynn |
Delaware |
0 |
2197679 |
0 |
0 |
2197679 |
9.87 % |
05/08/2014 |
| Deerfield Special Situations International Master Fund, L.P. |
Delaware |
0 |
181633 |
0 |
0 |
181633 |
0.82 % |
05/08/2014 |
| Deerfield International Master Fund, L.P. |
Delaware |
0 |
627267 |
0 |
0 |
627267 |
2.82 % |
05/08/2014 |
| Deerfield Mgmt III, L.P. |
Delaware |
0 |
654285 |
0 |
0 |
654285 |
2.94 % |
05/08/2014 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
227294 |
0 |
0 |
227294 |
1.02 % |
05/08/2014 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
2197679 |
0 |
0 |
2197679 |
9.87 % |
05/08/2014 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
2197679 |
0 |
0 |
2197679 |
9.87 % |
05/08/2014 |
| Deerfield International Master Fund, L.P. |
Delaware |
0 |
627267 |
0 |
0 |
627267 |
2.82 % |
05/08/2014 |
| Deerfield Special Situations International Master Fund, L.P. |
Delaware |
0 |
181633 |
0 |
0 |
181633 |
0.82 % |
05/08/2014 |