| David Bonderman |
Delaware |
0 |
1112290 |
0 |
0 |
1112290 |
18.9 % |
14/05/2019 |
| James Coulter |
Delaware |
0 |
1112290 |
0 |
0 |
1112290 |
18.9 % |
14/05/2019 |
| TPG Group Holdings (SBS) Advisors, Inc. |
Delaware |
0 |
1112290 |
0 |
0 |
1112290 |
18.9 % |
14/05/2019 |
| Domain Partners VIII, L.P. |
Delaware |
3036044 |
0 |
3036044 |
10 |
3036044 |
52.3 % |
13/05/2019 |
| DP VIII Associates, L.P. |
Delaware |
22527 |
0 |
22527 |
10 |
22527 |
0.4 % |
13/05/2019 |
| Advisors LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2019 |
| 2 |
United States of America |
0 |
429108 |
0 |
429108 |
429108 |
8.6 % |
14/02/2018 |
| Sciences Master Fund, Ltd. |
Delaware, United States of America |
0 |
1764708 |
0 |
0 |
1764708 |
5.94 % |
14/02/2017 |
| Advisors LLC |
Delaware, United States of America |
0 |
1921951 |
0 |
0 |
1921951 |
6.74 % |
14/02/2017 |
| Joseph Edelman |
Delaware, United States of America |
0 |
1921951 |
0 |
0 |
1921951 |
6.74 % |
14/02/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Deerfield Partners, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| James E. Flynn |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
| Sabby Healthcare Master Fund, Ltd. |
Cayman Islands |
0 |
1488108 |
0 |
1488108 |
1488108 |
5.38 % |
31/03/2016 |
| 2. |
Delaware, United States of America |
0 |
1921951 |
0 |
1921951 |
1921951 |
6.95 % |
16/02/2016 |
| 2. |
Delaware, United States of America |
0 |
1921951 |
0 |
1921951 |
1921951 |
6.95 % |
16/02/2016 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
1880134 |
0 |
0 |
1880134 |
6.8 % |
16/02/2016 |
| Deerfield Partners, L.P. |
Delaware |
0 |
93018 |
0 |
0 |
93018 |
0.34 % |
16/02/2016 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
1880134 |
0 |
0 |
1880134 |
6.8 % |
16/02/2016 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
1668729 |
0 |
0 |
1668729 |
6.03 % |
16/02/2016 |
| James E. Flynn |
United States |
0 |
1880134 |
0 |
0 |
1880134 |
6.8 % |
16/02/2016 |
| Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
118387 |
0 |
0 |
118387 |
0.43 % |
16/02/2016 |
| Perceptive Advisors LLC |
Delaware, United States of America |
0 |
1921951 |
0 |
|
1921951 |
7.88 % |
08/05/2015 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
1875000 |
0 |
0 |
1875000 |
8.01 % |
04/05/2015 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
1875000 |
0 |
0 |
1875000 |
8.01 % |
04/05/2015 |
| Deerfield Partners, L.P. |
Delaware |
0 |
154000 |
0 |
0 |
154000 |
0.66 % |
04/05/2015 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
1525000 |
0 |
0 |
1525000 |
6.52 % |
04/05/2015 |
| Deerfield International Master Fund, L.P. |
Delaware |
0 |
196000 |
0 |
0 |
196000 |
0.84 % |
04/05/2015 |
| James E. Flynn |
Delaware |
0 |
1875000 |
0 |
0 |
1875000 |
8.01 % |
04/05/2015 |
| Joseph Edelman |
Delaware, United States of America |
0 |
1121951 |
0 |
21 |
1121951 |
6.94 % |
17/02/2015 |
| Advisors LLC |
Delaware, United States of America |
0 |
1121951 |
0 |
0 |
1121951 |
6.94 % |
17/02/2015 |
| David Johnson |
U.S.A. |
1119028 |
0 |
1119028 |
10 |
1119028 |
6.8 % |
27/05/2014 |
| Broadfin Capital, LLC |
Delaware |
0 |
696864 |
0 |
696864 |
696864 |
7.04 % |
14/02/2014 |
| Broadfin Capital, LLC |
United States of America |
0 |
774393 |
0 |
774393 |
774393 |
7.83 % |
27/11/2013 |
| Broadfin Healthcare Master Fund, Ltd. |
United States of America |
0 |
774393 |
0 |
774393 |
774393 |
7.83 % |
27/11/2013 |
| Kevin Kotler |
United States of America |
0 |
774393 |
0 |
774393 |
774393 |
7.83 % |
27/11/2013 |
| Gamma Investments Trust |
of America |
11408009 |
0 |
11408009 |
0 |
11408009 |
3.7 % |
18/11/2013 |
| Frost Gamma Investments Trust |
Florida |
25761618 |
0 |
25761618 |
0 |
25761618 |
11.1 % |
03/04/2012 |
| Frost Gamma Investments Trust |
: |
0 |
0 |
0 |
0 |
15761618 |
7.54 % |
23/06/2011 |
| 12th Street Financial, LLC |
Delaware |
10000000 |
0 |
10000000 |
0 |
10000000 |
5 % |
25/08/2010 |
| S.S. |
Jersey |
35794498 |
0 |
35794498 |
10 |
35794498 |
17.9 % |
21/05/2010 |
| S.S. |
Virgin Islands |
27981999 |
0 |
27981999 |
10 |
27981999 |
14 % |
21/05/2010 |
| S.S. |
States |
0 |
35794498 |
0 |
10 |
35794498 |
17.9 % |
21/05/2010 |
| S.S. |
States |
0 |
35794498 |
0 |
10 |
35794498 |
17.9 % |
21/05/2010 |
| S.S. |
Virgin Islands |
7812499 |
0 |
7812499 |
10 |
7812499 |
3.9 % |
21/05/2010 |
