| (1) BlackRock, Inc. |
Delaware |
4729966 |
0 |
4862407 |
0 |
4862407 |
7.9 % |
11/03/2022 |
| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
0 |
0 |
4862407 |
7.9 % |
08/02/2022 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3395600 |
0 |
0 |
3880572 |
6.32 % |
04/02/2022 |
| Wellington Management Company LLP |
Delaware |
0 |
3350194 |
0 |
0 |
3733201 |
6.08 % |
04/02/2022 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3395600 |
0 |
0 |
3880572 |
6.32 % |
04/02/2022 |
| Wellington Group Holdings LLP |
Delaware |
0 |
3395600 |
0 |
0 |
3880572 |
6.32 % |
04/02/2022 |
| Avoro Capital Advisors LLC |
Delaware |
4190000 |
0 |
4190000 |
0 |
4190000 |
7.2 % |
12/02/2021 |
| Behzad Aghazadeh |
United States |
4190000 |
0 |
4190000 |
0 |
4190000 |
7.2 % |
12/02/2021 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
3214971 |
0 |
3214971 |
8.188 % |
13/02/2018 |
| Select Biotechnology Portfolio |
Massachusetts |
2267082 |
0 |
0 |
0 |
2267082 |
5.774 % |
13/02/2018 |
| FMR LLC |
Delaware |
18155 |
0 |
3214971 |
0 |
3214971 |
8.188 % |
13/02/2018 |
| Wellington Management Company LLP |
Delaware |
0 |
2220219 |
0 |
0 |
2929691 |
7.46 % |
08/02/2018 |
| Wellington Group Holdings LLP |
Delaware |
0 |
2370082 |
0 |
0 |
3611173 |
9.2 % |
08/02/2018 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2370082 |
0 |
0 |
3611173 |
9.2 % |
08/02/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2370082 |
0 |
0 |
3611173 |
9.2 % |
08/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
3018785 |
0 |
3107925 |
0 |
3107925 |
7.9 % |
29/01/2018 |
| Great Point Partners, LLC |
USA |
0 |
30000000 |
0 |
30000000 |
30000000 |
9.75 % |
28/04/2017 |
| Mr. David Kroin |
USA |
0 |
30000000 |
0 |
30000000 |
30000000 |
9.75 % |
28/04/2017 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
30000000 |
0 |
30000000 |
30000000 |
9.75 % |
28/04/2017 |
| FMR LLC |
Delaware |
3594 |
0 |
14127346 |
0 |
14127346 |
5.824 % |
12/02/2016 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
7479424 |
0 |
0 |
7479424 |
3.44 % |
14/02/2013 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
7479424 |
0 |
0 |
7479424 |
3.44 % |
14/02/2013 |
| Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
2371571 |
0 |
0 |
2371571 |
1.09 % |
14/02/2013 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
327831 |
0 |
0 |
327831 |
0.15 % |
14/02/2013 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
384937 |
0 |
0 |
384937 |
0.18 % |
14/02/2013 |
| Deerfield Private Design Fund, L.P. |
Delaware |
0 |
1064129 |
0 |
0 |
1064129 |
0.49 % |
14/02/2013 |
| Deerfield Private Design International, L.P. |
British Virgin Islands |
0 |
1714439 |
0 |
0 |
1714439 |
0.79 % |
14/02/2013 |
| James E. Flynn |
United States |
0 |
7479424 |
0 |
0 |
7479424 |
3.44 % |
14/02/2013 |
| Deerfield Partners, L.P. |
Delaware |
0 |
1616517 |
0 |
0 |
1616517 |
0.74 % |
14/02/2013 |
| BIOTECHNOLOGY VALUE FUND, L.P. |
Pennsylvania For |
307442 |
0 |
12424661 |
298042 |
820948 |
1.2 % |
13/02/2013 |
| (1) BlackRock, Inc. |
Delaware |
12859067 |
0 |
12859067 |
0 |
12859067 |
5.92 % |
08/02/2013 |
| BlackRock for purposes of Schedule 13G filings. |
Delaware |
5643752 |
0 |
5643752 |
0 |
5643752 |
6.09 % |
29/01/2010 |
| Deerfield Partners, L.P. |
Delaware |
0 |
2547304 |
0 |
2547304 |
2547304 |
3.44 % |
13/02/2009 |
| Deerfield Management Company, L.P. |
New York |
0 |
4412544 |
0 |
4412544 |
4412544 |
5.96 % |
13/02/2009 |
| Deerfield International Limited |
British Virgin Islands |
0 |
4412544 |
0 |
4412544 |
4412544 |
5.96 % |
13/02/2009 |
| James E. Flynn |
United States |
0 |
6959848 |
0 |
6959848 |
6959848 |
9.4 % |
13/02/2009 |
| Deerfield Capital, L.P. |
Delaware |
0 |
2547304 |
0 |
2547304 |
2547304 |
3.44 % |
13/02/2009 |
| Oppenheimer Global Opportunities Fund |
Colorado |
0 |
6000000 |
0 |
0 |
6000000 |
8.1 % |
23/01/2009 |
| OppenheimerFunds, Inc. |
Colorado |
0 |
6155057 |
0 |
0 |
6155057 |
8.31 % |
23/01/2009 |
| Deerfield International Limited |
British Virgin Islands |
0 |
3838165 |
0 |
3838165 |
3838165 |
5.32 % |
14/02/2008 |
| James E. Flynn |
United States |
0 |
5950643 |
0 |
5950643 |
5950643 |
8.25 % |
14/02/2008 |
| Deerfield Capital, L.P. |
Delaware |
0 |
2112478 |
0 |
2112478 |
2112478 |
2.93 % |
14/02/2008 |
| Deerfield Partners, L.P. |
Delaware |
0 |
2112478 |
0 |
2112478 |
2112478 |
2.93 % |
14/02/2008 |
| Deerfield Management Company, L.P. |
New York |
0 |
3838165 |
0 |
3838165 |
3838165 |
5.32 % |
14/02/2008 |
| Deerfield Management Company, L.P. |
New York |
0 |
3868008 |
0 |
3868008 |
3868008 |
6.27 % |
23/10/2007 |
| Deerfield International Limited |
British Virgin Islands |
0 |
3868008 |
0 |
3868008 |
3868008 |
6.27 % |
23/10/2007 |
| Deerfield Partners, L.P. |
Delaware |
0 |
2232635 |
0 |
2232635 |
2232635 |
3.64 % |
23/10/2007 |
| Deerfield Capital, L.P. |
Delaware |
0 |
2232635 |
0 |
2232635 |
2232635 |
3.64 % |
23/10/2007 |
| James E. Flynn |
United States |
0 |
6100643 |
0 |
6100643 |
6100643 |
9.83 % |
23/10/2007 |
| James E. Flynn |
United States |
0 |
3490150 |
0 |
3490150 |
3490150 |
5.92 % |
02/02/2007 |
| Deerfield Partners, L.P. |
Delaware |
0 |
1364641 |
0 |
1364641 |
1364641 |
2.32 % |
02/02/2007 |
| Deerfield Management Company, L.P. |
New York |
0 |
2125509 |
0 |
2125509 |
2125509 |
3.61 % |
02/02/2007 |
| Deerfield International Limited |
British Virgin Islands |
0 |
2125509 |
0 |
2125509 |
2125509 |
3.61 % |
02/02/2007 |
| Deerfield Capital, L.P. |
Delaware |
0 |
1364641 |
0 |
1364641 |
1364641 |
2.32 % |
02/02/2007 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
3506922 |
0 |
3506922 |
9.91 % |
14/02/2006 |
| FMR Corp. |
Delaware |
0 |
0 |
3506922 |
0 |
3506922 |
9.91 % |
14/02/2006 |
| 04-2683227 |
Massachusetts |
0 |
2316676 |
0 |
0 |
2945376 |
8.32 % |
14/02/2006 |
| (. |
Citizenship or Place of Organization |
1741786 |
0 |
1741786 |
0 |
1741786 |
6.8 % |
06/02/2004 |
| BVF Inc. |
Delaware |
0 |
3130912 |
0 |
10 |
3130912 |
12.2 % |
23/01/2004 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
592884 |
0 |
10 |
592884 |
2.3 % |
23/01/2004 |
| BVF Investments, L.L.C. |
Delaware |
0 |
1556351 |
0 |
10 |
1556351 |
6.1 % |
23/01/2004 |
| BVF Partners L.P. |
Delaware |
0 |
3130912 |
0 |
10 |
3130912 |
12.2 % |
23/01/2004 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
920477 |
0 |
10 |
920477 |
3.6 % |
23/01/2004 |
| Perry Corp. |
New York |
2598802 |
0 |
2598802 |
0 |
2598802 |
9.38 % |
10/02/2003 |
| Richard C. Perry |
United States |
2598802 |
0 |
2598802 |
0 |
2598802 |
9.38 % |
10/02/2003 |
| Tripos, Inc. |
Utah |
1915840 |
0 |
1915840 |
0 |
1915840 |
6.9 % |
06/02/2002 |