| BlackRock, Inc. |
Delaware |
4729966 |
0 |
4862407 |
0 |
4862407 |
7.9 % |
11/03/2022 |
| Avoro Capital Advisors LLC |
Delaware |
1235000 |
0 |
1235000 |
0 |
1235000 |
2 % |
11/02/2022 |
| Behzad Aghazadeh |
United States |
1235000 |
0 |
1235000 |
0 |
1235000 |
2 % |
11/02/2022 |
| The Vanguard Group |
Pennsylvania |
0 |
56700 |
5596407 |
110288 |
5706695 |
9.3 % |
09/02/2022 |
| The Vanguard Group |
Pennsylvania For |
0 |
56700 |
5596407 |
110288 |
5706695 |
9.3 % |
09/02/2022 |
| BlackRock, Inc. |
Delaware |
0 |
0 |
0 |
0 |
4862407 |
7.9 % |
08/02/2022 |
| Wellington Management Company LLP |
Delaware |
0 |
3350194 |
0 |
3733201 |
3733201 |
6.08 % |
04/02/2022 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3395600 |
0 |
3880572 |
3880572 |
6.32 % |
04/02/2022 |
| Wellington Group Holdings LLP |
Delaware |
0 |
3395600 |
0 |
3880572 |
3880572 |
6.32 % |
04/02/2022 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3395600 |
0 |
3880572 |
3880572 |
6.32 % |
04/02/2022 |
| Behzad Aghazadeh |
United States |
4190000 |
0 |
4190000 |
0 |
4190000 |
7.2 % |
12/02/2021 |
| Avoro Capital Advisors LLC |
Delaware |
4190000 |
0 |
4190000 |
0 |
4190000 |
7.2 % |
12/02/2021 |
| The Vanguard Group |
Pennsylvania For |
0 |
64094 |
5153068 |
110771 |
5263839 |
9.05 % |
10/02/2021 |
| The Vanguard Group |
Pennsylvania |
0 |
64094 |
5153068 |
110771 |
5263839 |
9.05 % |
10/02/2021 |
| BlackRock, Inc. |
Delaware |
5279905 |
0 |
5390560 |
0 |
5390560 |
9.3 % |
28/01/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
5521833 |
0 |
6289051 |
6289051 |
10.81 % |
11/01/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
5521833 |
0 |
6289051 |
6289051 |
10.81 % |
11/01/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
5521833 |
0 |
6289051 |
6289051 |
10.81 % |
11/01/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
5521833 |
0 |
6289051 |
6289051 |
10.81 % |
11/01/2021 |
| Wellington Management Company LLP |
Delaware |
0 |
5325249 |
0 |
5602740 |
5602740 |
9.63 % |
11/01/2021 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
5521833 |
0 |
6289051 |
6289051 |
10.81 % |
11/01/2021 |
| Wellington Management Company LLP |
Delaware |
0 |
5325249 |
0 |
5602740 |
5602740 |
9.63 % |
11/01/2021 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
5521833 |
0 |
6289051 |
6289051 |
10.81 % |
11/01/2021 |
| BlackRock, Inc. |
Delaware |
5011270 |
0 |
5099863 |
0 |
5099863 |
10.1 % |
09/04/2020 |
| Brian D. Grossman |
U.S. Citizen |
0 |
1080100 |
0 |
1080100 |
1080100 |
2.2 % |
14/02/2020 |
| Partner Fund Management, L.P. |
Delaware |
0 |
1070616 |
0 |
1070616 |
1070616 |
2.1 % |
14/02/2020 |
| Partner Investment Management GP, LLC |
Delaware |
0 |
9484 |
0 |
9484 |
9484 |
0.1 % |
14/02/2020 |
| Partner Investment Management, L.P. |
Delaware |
0 |
9484 |
0 |
9484 |
9484 |
0.1 % |
14/02/2020 |
| Partner Fund Management GP, LLC |
Delaware |
0 |
1070616 |
0 |
1070616 |
1070616 |
2.1 % |
14/02/2020 |
| Christopher M. James |
U.S. Citizen |
0 |
1080100 |
0 |
1080100 |
1080100 |
2.2 % |
14/02/2020 |
| The Vanguard Group |
Pennsylvania |
95153 |
7167 |
4461373 |
95390 |
4556763 |
9.09 % |
12/02/2020 |
| The Vanguard Group |
Pennsylvania |
95153 |
7167 |
4461373 |
95390 |
4556763 |
9.09 % |
12/02/2020 |
| BlackRock, Inc. |
Delaware |
4821688 |
0 |
4916922 |
0 |
4916922 |
9.8 % |
05/02/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
4077608 |
0 |
4675863 |
4675863 |
9.33 % |
27/01/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
4077608 |
0 |
4675863 |
4675863 |
9.33 % |
27/01/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
4077608 |
0 |
4675863 |
4675863 |
9.33 % |
27/01/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4077608 |
0 |
4675863 |
4675863 |
9.33 % |
27/01/2020 |
| Wellington Management Company LLP |
Delaware |
0 |
3918211 |
0 |
4017306 |
4017306 |
8.02 % |
27/01/2020 |
| Wellington Management Company LLP |
Delaware |
0 |
3918211 |
0 |
4017306 |
4017306 |
8.02 % |
27/01/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
4077608 |
0 |
4675863 |
4675863 |
9.33 % |
27/01/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
4077608 |
0 |
4675863 |
4675863 |
9.33 % |
27/01/2020 |
| Partner Fund Management GP, LLC |
Delaware |
0 |
3014672 |
0 |
3014672 |
3014672 |
6.1 % |
14/02/2019 |
| Partner Fund Management, L.P. |
Delaware |
0 |
3014672 |
0 |
3014672 |
3014672 |
6.1 % |
14/02/2019 |
| Partner Investment Management, L.P. |
Delaware |
0 |
39408 |
0 |
39408 |
39408 |
0.1 % |
14/02/2019 |
| Partner Investment Management GP, LLC |
Delaware |
0 |
39408 |
0 |
39408 |
39408 |
0.1 % |
14/02/2019 |
| Brian D. Grossman |
U.S. Citizen |
0 |
3054080 |
0 |
3054080 |
3054080 |
6.2 % |
14/02/2019 |
| Christopher M. James |
U.S. Citizen |
0 |
3054080 |
0 |
3054080 |
3054080 |
6.2 % |
14/02/2019 |
| The Vanguard Group |
Pennsylvania |
91494 |
6043 |
4598300 |
93167 |
4691467 |
9.49 % |
11/02/2019 |
| The Vanguard Group |
Pennsylvania |
91494 |
6043 |
4598300 |
93167 |
4691467 |
9.49 % |
11/02/2019 |
| BlackRock, Inc. |
Delaware |
4671709 |
0 |
4776807 |
0 |
4776807 |
9.7 % |
04/02/2019 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3083948 |
0 |
4949799 |
4949799 |
10.02 % |
10/01/2019 |
| Wellington Group Holdings LLP |
Delaware |
0 |
3083948 |
0 |
4949799 |
4949799 |
10.02 % |
10/01/2019 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3083948 |
0 |
4949799 |
4949799 |
10.02 % |
10/01/2019 |
| Wellington Management Company LLP |
Delaware |
0 |
2929261 |
0 |
4259523 |
4259523 |
8.62 % |
10/01/2019 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3083948 |
0 |
4949799 |
4949799 |
10.02 % |
10/01/2019 |
| Wellington Group Holdings LLP |
Delaware |
0 |
3083948 |
0 |
4949799 |
4949799 |
10.02 % |
10/01/2019 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3083948 |
0 |
4949799 |
4949799 |
10.02 % |
10/01/2019 |
| Wellington Management Company LLP |
Delaware |
0 |
2929261 |
0 |
4259523 |
4259523 |
8.62 % |
10/01/2019 |
| FMR LLC |
Delaware |
92843 |
0 |
2427123 |
0 |
2427123 |
4.918 % |
13/11/2018 |
| FMR LLC |
Delaware |
92843 |
0 |
2427123 |
0 |
2427123 |
4.918 % |
13/11/2018 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2427123 |
0 |
2427123 |
4.918 % |
13/11/2018 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
2427123 |
0 |
2427123 |
4.918 % |
13/11/2018 |
| Partner Fund Management, L.P. |
Delaware |
0 |
2510173 |
0 |
2510173 |
2510173 |
5.1 % |
27/08/2018 |
| Partner Fund Management GP, LLC |
Delaware |
0 |
2510173 |
0 |
2510173 |
2510173 |
5.1 % |
27/08/2018 |
| Partner Investment Management, L.P. |
Delaware |
0 |
31080 |
0 |
31080 |
31080 |
0.1 % |
27/08/2018 |
| Partner Investment Management GP, LLC |
Delaware |
0 |
31080 |
0 |
31080 |
31080 |
0.1 % |
27/08/2018 |
| Brian D. Grossman |
U.S. Citizen |
0 |
2541981 |
0 |
2541981 |
2541981 |
5.2 % |
27/08/2018 |
| Christopher M. James |
U.S. Citizen |
0 |
2541981 |
0 |
2541981 |
2541981 |
5.2 % |
27/08/2018 |
| Partner Fund Management, L.P. |
Delaware |
0 |
2510173 |
0 |
2510173 |
2510173 |
5.1 % |
27/08/2018 |
| Partner Fund Management GP, LLC |
Delaware |
0 |
2510173 |
0 |
2510173 |
2510173 |
5.1 % |
27/08/2018 |
| Partner Investment Management, L.P. |
Delaware |
0 |
31080 |
0 |
31080 |
31080 |
0.1 % |
27/08/2018 |
| Partner Investment Management GP, LLC |
Delaware |
0 |
31080 |
0 |
31080 |
31080 |
0.1 % |
27/08/2018 |
| Brian D. Grossman |
U.S. Citizen |
0 |
2541981 |
0 |
2541981 |
2541981 |
5.2 % |
27/08/2018 |
| Christopher M. James |
U.S. Citizen |
0 |
2541981 |
0 |
2541981 |
2541981 |
5.2 % |
27/08/2018 |
| FMR LLC |
Delaware |
290728 |
0 |
5357199 |
0 |
5357199 |
10.92 % |
10/04/2018 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
5357199 |
0 |
5357199 |
10.92 % |
10/04/2018 |
| FMR LLC |
Delaware |
290728 |
0 |
5357199 |
0 |
5357199 |
10.92 % |
10/04/2018 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
5357199 |
0 |
5357199 |
10.92 % |
10/04/2018 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
1177119 |
0 |
1177119 |
1177119 |
3 % |
14/02/2018 |
| Great Point Partners, LLC |
USA |
0 |
1177119 |
0 |
1177119 |
1177119 |
3 % |
14/02/2018 |
| Mr. David Kroin |
USA |
0 |
1177119 |
0 |
1177119 |
1177119 |
3 % |
14/02/2018 |
| Great Point Partners, LLC |
USA |
0 |
1177119 |
0 |
1177119 |
1177119 |
3 % |
14/02/2018 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
1177119 |
0 |
1177119 |
1177119 |
3 % |
14/02/2018 |
| Mr. David Kroin |
USA |
0 |
1177119 |
0 |
1177119 |
1177119 |
3 % |
14/02/2018 |
| FMR LLC |
Delaware |
18155 |
0 |
3214971 |
0 |
3214971 |
8.188 % |
13/02/2018 |
| Select Biotechnology Portfolio |
Massachusetts |
2267082 |
0 |
0 |
0 |
2267082 |
5.774 % |
13/02/2018 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
3214971 |
0 |
3214971 |
8.188 % |
13/02/2018 |
| The Vanguard Group |
Pennsylvania |
76626 |
5100 |
3125839 |
78756 |
3204595 |
8.16 % |
12/02/2018 |
| The Vanguard Group |
Pennsylvania |
76626 |
5100 |
3125839 |
78756 |
3204595 |
8.16 % |
12/02/2018 |
| Wellington Group Holdings LLP |
Delaware |
0 |
2370082 |
0 |
3611173 |
3611173 |
9.2 % |
08/02/2018 |
| Wellington Management Company LLP |
Delaware |
0 |
2220219 |
0 |
2929691 |
2929691 |
7.46 % |
08/02/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2370082 |
0 |
3611173 |
3611173 |
9.2 % |
08/02/2018 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2370082 |
0 |
3611173 |
3611173 |
9.2 % |
08/02/2018 |
| BlackRock, Inc. |
Delaware |
3018785 |
0 |
3107925 |
0 |
3107925 |
7.9 % |
29/01/2018 |
| Dr. Jeffrey R. Jay, M.D. |
USA |
0 |
30000000 |
0 |
30000000 |
30000000 |
9.75 % |
28/04/2017 |
| Great Point Partners, LLC |
USA |
0 |
30000000 |
0 |
30000000 |
30000000 |
9.75 % |
28/04/2017 |
| Mr. David Kroin |
USA |
0 |
30000000 |
0 |
30000000 |
30000000 |
9.75 % |
28/04/2017 |
| FMR LLC |
Delaware |
1053 |
0 |
5986705 |
0 |
5986705 |
2.46 % |
14/02/2017 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
5986705 |
0 |
5986705 |
2.46 % |
14/02/2017 |
| The Vanguard Group |
Pennsylvania |
484132 |
36018 |
18487505 |
507450 |
18994955 |
7.8 % |
09/02/2017 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
16091035 |
0 |
23035452 |
23035452 |
9.47 % |
09/02/2017 |
| Wellington Management Company LLP |
Delaware |
0 |
15100335 |
0 |
20771250 |
20771250 |
8.54 % |
09/02/2017 |
| Wellington Management Group LLP |
Massachusetts |
0 |
16091035 |
0 |
23035452 |
23035452 |
9.47 % |
09/02/2017 |
| Wellington Group Holdings LLP |
Delaware |
0 |
16091035 |
0 |
23035452 |
23035452 |
9.47 % |
09/02/2017 |
| BlackRock, Inc. |
Delaware |
18400585 |
0 |
18924133 |
0 |
18924133 |
7.8 % |
19/01/2017 |
| FMR LLC |
Delaware |
3594 |
0 |
14127346 |
0 |
14127346 |
5.824 % |
12/02/2016 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
14127346 |
0 |
14127346 |
5.824 % |
12/02/2016 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
17968042 |
0 |
25030751 |
25030751 |
10.32 % |
11/02/2016 |
| Wellington Management Group LLP |
Massachusetts |
0 |
17968042 |
0 |
25030751 |
25030751 |
10.32 % |
11/02/2016 |
| Wellington Group Holdings LLP |
Delaware |
0 |
17968042 |
0 |
25030751 |
25030751 |
10.32 % |
11/02/2016 |
| Wellington Management Company LLP |
Delaware |
0 |
15443151 |
0 |
21167876 |
21167876 |
8.73 % |
11/02/2016 |
| The Vanguard Group |
Pennsylvania |
535993 |
23800 |
16624044 |
538593 |
17162637 |
7.07 % |
10/02/2016 |
| BlackRock, Inc. |
Delaware |
15441729 |
0 |
15984174 |
0 |
15984174 |
6.6 % |
25/01/2016 |
| Wellington Management Group LLP |
Massachusetts |
0 |
20558603 |
0 |
29101919 |
29101919 |
13.22 % |
12/02/2015 |
| The Vanguard Group |
Pennsylvania For |
301690 |
0 |
13614121 |
280490 |
13894611 |
6.31 % |
10/02/2015 |
| BlackRock, Inc. |
Delaware |
14810705 |
0 |
15295845 |
0 |
15295845 |
6.9 % |
29/01/2015 |
| Wellington Management Company, LLP |
Massachusetts |
0 |
19972159 |
0 |
30024014 |
30024014 |
13.74 % |
14/02/2014 |
| The Vanguard Group |
Pennsylvania For |
321731 |
0 |
13662762 |
301731 |
13964493 |
6.38 % |
11/02/2014 |
| BlackRock, Inc. |
Delaware |
15214455 |
0 |
16016015 |
0 |
16016015 |
7.3 % |
28/01/2014 |
| Wellington Management Company, LLP |
Massachusetts |
0 |
14891657 |
0 |
22271797 |
22271797 |
10.24 % |
10/04/2013 |
| The Vanguard Group |
Pennsylvania |
307442 |
|
12424661 |
298042 |
12722703 |
5.85 % |
22/02/2013 |
| S James E. Flynn |
United States |
0 |
7479424 |
0 |
7479424 |
7479424 |
3.44 % |
14/02/2013 |
| S Deerfield Mgmt, L.P. |
Delaware |
0 |
7479424 |
0 |
7479424 |
7479424 |
3.44 % |
14/02/2013 |
| S Deerfield Management Company, L.P. |
Delaware |
0 |
7479424 |
0 |
7479424 |
7479424 |
3.44 % |
14/02/2013 |
| S Deerfield Partners, L.P. |
Delaware |
0 |
1616517 |
0 |
1616517 |
1616517 |
0.74 % |
14/02/2013 |
| S Deerfield International Master Fund, L.P. |
British Virgin Islands |
0 |
2371571 |
0 |
2371571 |
2371571 |
1.09 % |
14/02/2013 |
| S Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
327831 |
0 |
327831 |
327831 |
0.15 % |
14/02/2013 |
| S Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
384937 |
0 |
384937 |
384937 |
0.18 % |
14/02/2013 |
| S Deerfield Private Design Fund, L.P. |
Delaware |
0 |
1064129 |
0 |
1064129 |
1064129 |
0.49 % |
14/02/2013 |
| S Deerfield Private Design International, L.P. |
British Virgin Islands |
0 |
1714439 |
0 |
1714439 |
1714439 |
0.79 % |
14/02/2013 |
| S Wellington Management Company, LLP |
Massachusetts |
0 |
12326506 |
0 |
18251636 |
18251636 |
8.4 % |
14/02/2013 |
| The Vanguard Group |
Pennsylvania For |
307442 |
0 |
12424661 |
298042 |
12722703 |
5.37 % |
13/02/2013 |
| BlackRock, Inc. |
Delaware |
12859067 |
0 |
12859067 |
0 |
12859067 |
5.92 % |
08/02/2013 |
| S Wellington Management Company, LLP |
Massachusetts |
0 |
5812871 |
0 |
8110367 |
8110367 |
5.55 % |
14/02/2012 |
| BlackRock, Inc. |
Delaware |
10505818 |
0 |
10505818 |
0 |
10505818 |
7.19 % |
13/02/2012 |
| Wellington Management Company, LLP |
Massachusetts |
0 |
6492371 |
0 |
9126367 |
9126367 |
6.25 % |
12/12/2011 |
| Wellington Management Company, LLP |
Massachusetts |
0 |
10697281 |
0 |
14443111 |
14443111 |
11.9 % |
14/02/2011 |
| Biotech Target N.V. : N/A |
Nerlands Antilles |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2011 |
| BB Biotech AG |
Switzerland |
0 |
0 |
0 |
0 |
0 |
0 % |
10/02/2011 |
| OppenheimerFunds, Inc. |
Colorado |
0 |
2800 |
0 |
2800 |
2800 |
0 % |
10/02/2011 |
| BlackRock, Inc. |
Delaware |
7548296 |
0 |
7548296 |
0 |
7548296 |
6.22 % |
02/02/2011 |
| J. Christopher Donahue |
United States |
0 |
3512694 |
0 |
3512694 |
3512694 |
3.47 % |
09/04/2010 |
| Rhodora J. Donahue |
United States |
0 |
3512694 |
0 |
3512694 |
3512694 |
3.47 % |
09/04/2010 |
| Federated Investors, Inc. |
Pennsylvania |
3512694 |
0 |
3512694 |
0 |
3512694 |
3.47 % |
09/04/2010 |
| Voting Shares Irrevocable Trust |
Pennsylvania |
3512694 |
0 |
3512694 |
0 |
3512694 |
3.47 % |
09/04/2010 |
| John F. Donahue |
United States |
0 |
3512694 |
0 |
3512694 |
3512694 |
3.47 % |
09/04/2010 |
| HBM BioVentures AG |
Switzerland |
0 |
0 |
0 |
0 |
0 |
0 % |
16/02/2010 |
| S Wellington Management Company, LLP |
Massachusetts |
0 |
10486157 |
0 |
12980468 |
12980468 |
14 % |
12/02/2010 |
| Rhodora J. Donahue |
United States |
0 |
8167154 |
0 |
8167154 |
8167154 |
8.81 % |
11/02/2010 |
| Voting Shares Irrevocable Trust |
Pennsylvania |
8167154 |
0 |
8167154 |
0 |
8167154 |
8.81 % |
11/02/2010 |
| Federated Investors, Inc. |
Pennsylvania |
8167154 |
0 |
8167154 |
0 |
8167154 |
8.81 % |
11/02/2010 |
| J. Christopher Donahue |
United States |
0 |
8167154 |
0 |
8167154 |
8167154 |
8.81 % |
11/02/2010 |
| John F. Donahue |
United States |
0 |
8167154 |
0 |
8167154 |
8167154 |
8.81 % |
11/02/2010 |
| BIOTECH TARGET N.V. : N/A |
NERLANDS ANTILLES |
0 |
5431980 |
0 |
5431980 |
5431980 |
5.9 % |
11/02/2010 |
| BB BIOTECH AG |
SWITZERLAND |
0 |
5431980 |
0 |
5431980 |
5431980 |
5.9 % |
11/02/2010 |
| Oppenheimer Global Opportunities Fund |
Colorado |
0 |
6000000 |
0 |
6000000 |
6000000 |
6.47 % |
01/02/2010 |
| OppenheimerFunds, Inc. |
Colorado |
0 |
6002500 |
0 |
6002500 |
6002500 |
6.47 % |
01/02/2010 |
| J. Christopher Donahue |
United States |
0 |
8167154 |
0 |
8167154 |
8167154 |
8.81 % |
11/01/2010 |
| Rhodora J. Donahue |
United States |
0 |
8167154 |
0 |
8167154 |
8167154 |
8.81 % |
11/01/2010 |
| John F. Donahue |
United States |
0 |
8167154 |
0 |
8167154 |
8167154 |
8.81 % |
11/01/2010 |
| Voting Shares Irrevocable Trust |
Pennsylvania |
8167154 |
0 |
8167154 |
0 |
8167154 |
8.81 % |
11/01/2010 |
| Federated Investors, Inc. |
Pennsylvania |
8167154 |
0 |
8167154 |
0 |
8167154 |
8.81 % |
11/01/2010 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1001300 |
0 |
1001300 |
1001300 |
3.6 % |
06/05/2002 |
| BVF Partners L.P. |
Delaware |
0 |
5003620 |
0 |
5003620 |
5003620 |
18.1 % |
06/05/2002 |
| BVF Inc. |
Delaware |
0 |
5003620 |
0 |
5003620 |
5003620 |
18.1 % |
06/05/2002 |
| BVF Investments, L.L.C. |
Delaware |
0 |
2270800 |
0 |
2270800 |
2270800 |
8.2 % |
06/05/2002 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
1527320 |
0 |
1527320 |
1527320 |
5.5 % |
06/05/2002 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
963220 |
0 |
963220 |
963220 |
3.5 % |
15/04/2002 |
| BVF Investments, L.L.C. |
Delaware |
0 |
1404800 |
0 |
1404800 |
1404800 |
5.1 % |
15/04/2002 |
| BVF Partners L.P. |
Delaware |
0 |
3123520 |
0 |
3123520 |
3123520 |
11.3 % |
15/04/2002 |
| BVF Inc. |
Delaware |
0 |
3123520 |
0 |
3123520 |
3123520 |
11.3 % |
15/04/2002 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
624300 |
0 |
624300 |
624300 |
2.3 % |
15/04/2002 |