STATE STREET CORPORATION |
MA |
0 |
5936957 |
0 |
6354331 |
6354331 |
5.1 % |
16/10/2024 |
The Vanguard Group |
Pennsylvania |
0 |
187110 |
10376587 |
295489 |
10672076 |
9.93 % |
13/02/2024 |
STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
6505791 |
0 |
6825111 |
6825111 |
6.35 % |
24/01/2024 |
The Vanguard Group |
Pennsylvania For |
0 |
176502 |
10540771 |
289662 |
10830433 |
10.13 % |
09/06/2023 |
The Vanguard Group |
Pennsylvania |
0 |
176634 |
10005222 |
280950 |
10286172 |
9.7 % |
09/02/2023 |
BlackRock, Inc. |
Delaware |
0 |
0 |
0 |
0 |
12710631 |
12 % |
20/01/2023 |
The Vanguard Group |
Pennsylvania |
0 |
191955 |
9358719 |
281424 |
9640143 |
9.22 % |
09/02/2022 |
BlackRock, Inc. |
Delaware |
11860689 |
0 |
12008063 |
0 |
12008063 |
11.5 % |
27/01/2022 |
BlackRock, Inc. |
Delaware |
11872190 |
0 |
12008063 |
0 |
12008063 |
11.5 % |
25/01/2022 |
The Vanguard Group |
Pennsylvania |
0 |
231805 |
8968990 |
312561 |
9281551 |
9.03 % |
10/02/2021 |
BlackRock, Inc. |
Delaware |
12403468 |
0 |
12563132 |
0 |
12563132 |
12.2 % |
26/01/2021 |
Roderick Wong |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
RTW Investments, LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
The Vanguard Group |
Pennsylvania |
196261 |
17849 |
9594203 |
203304 |
9797507 |
9.78 % |
11/02/2020 |
FT MANHATTAN CO131957714 |
USA |
1860455 |
926220 |
1860455 |
961270 |
2821725 |
2.96 % |
04/02/2020 |
FT MANHATTAN CO131957714 |
USA |
1860455 |
926220 |
1860455 |
961270 |
2821725 |
2.96 % |
04/02/2020 |
BlackRock, Inc. |
Delaware |
12149645 |
0 |
12360958 |
0 |
12360958 |
12.3 % |
04/02/2020 |
The Vanguard Group |
Pennsylvania |
198567 |
16160 |
10639170 |
205401 |
10844571 |
11.37 % |
10/10/2019 |
The Vanguard Group |
Pennsylvania |
198567 |
16160 |
10639170 |
205401 |
10844571 |
11.37 % |
10/10/2019 |
BlackRock, Inc. |
Delaware |
14646012 |
0 |
14869280 |
0 |
14869280 |
15.7 % |
07/06/2019 |
BlackRock, Inc. |
Delaware |
6999384 |
0 |
7184621 |
0 |
7184621 |
7.8 % |
07/02/2019 |
OppenheimerFunds, Inc. |
Colorado |
0 |
7806082 |
0 |
7806082 |
7806082 |
8.46 % |
14/01/2019 |
OppenheimerFunds, Inc. |
Colorado |
0 |
7806082 |
0 |
7806082 |
7806082 |
8.46 % |
14/01/2019 |
Roderick Wong |
United States of America |
0 |
4358067 |
0 |
4358067 |
4358067 |
5.02 % |
14/05/2018 |
Roderick Wong |
United States of America |
0 |
4358067 |
0 |
4358067 |
4358067 |
5.02 % |
14/05/2018 |
RTW Investments, LP |
Delaware |
0 |
4358067 |
0 |
4358067 |
4358067 |
5.02 % |
14/05/2018 |
RTW Investments, LP |
Delaware |
0 |
4358067 |
0 |
4358067 |
4358067 |
5.02 % |
14/05/2018 |
OppenheimerFunds, Inc. |
Colorado |
0 |
6300000 |
0 |
6300000 |
6300000 |
8.42 % |
06/02/2018 |
BlackRock, Inc. |
Delaware |
2464607 |
0 |
2464607 |
0 |
2464607 |
3.3 % |
10/07/2017 |
Felix J. Baker |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
Julian C. Baker |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
Baker Bros. Advisors LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
Baker Bros. Advisors LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2017 |
Oppenheimer Global Opportunities Fund |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
4.04 % |
14/02/2017 |
OppenheimerFunds, Inc. |
Colorado |
0 |
3000000 |
0 |
3000000 |
3000000 |
4.04 % |
14/02/2017 |
BlackRock, Inc. |
Delaware |
4954660 |
0 |
5093721 |
0 |
5093721 |
6.9 % |
19/01/2017 |
Baker Bros. Advisors |
Delaware |
3680499 |
0 |
3680499 |
0 |
3680499 |
5.9 % |
16/02/2016 |
Felix J. Baker |
United States |
3680499 |
0 |
3680499 |
0 |
3680499 |
5.9 % |
16/02/2016 |
Julian C. Baker |
United States |
3680499 |
0 |
3680499 |
0 |
3680499 |
5.9 % |
16/02/2016 |
Baker Bros. Advisors LP |
Delaware |
3680499 |
0 |
3680499 |
0 |
3680499 |
5.9 % |
16/02/2016 |
OppenheimerFunds, Inc. |
Colorado |
0 |
3000000 |
0 |
3000000 |
3000000 |
5.04 % |
01/02/2016 |
Oppenheimer Global Opportunities Fund |
Delaware |
0 |
3000000 |
0 |
3000000 |
3000000 |
5.04 % |
01/02/2016 |
BlackRock, Inc. |
Delaware |
3951764 |
0 |
4085277 |
0 |
4085277 |
6.9 % |
25/01/2016 |
Millennium International Management GP LLC |
|
|
|
|
|
8700 |
0 % |
22/01/2016 |
Millennium Management LLC |
|
|
|
|
|
51285 |
0.1 % |
22/01/2016 |
Israel A. Englander |
|
|
|
|
|
51285 |
0.1 % |
22/01/2016 |
Integrated Core Strategies (US) LLC |
|
|
|
|
|
42585 |
0.1 % |
22/01/2016 |
ICS Opportunities, Ltd. |
|
|
|
|
|
0 |
0 % |
22/01/2016 |
Integrated Assets, Ltd. |
|
|
|
|
|
8700 |
0 % |
22/01/2016 |
Millennium International Management LP |
|
|
|
|
|
8700 |
0 % |
22/01/2016 |
Millennium International Management GP LLC |
|
|
|
|
|
1663622 |
3 % |
07/04/2015 |
Integrated Core Strategies (US) LLC |
|
|
|
|
|
1966084 |
3.6 % |
07/04/2015 |
Israel A. Englander |
|
|
|
|
|
3629706 |
6.6 % |
07/04/2015 |
Millennium Management LLC |
|
|
|
|
|
3629706 |
6.6 % |
07/04/2015 |
Integrated Assets, Ltd. |
|
|
|
|
|
334173 |
0.6 % |
07/04/2015 |
Millennium International Management LP |
|
|
|
|
|
1663622 |
3 % |
07/04/2015 |
ICS Opportunities, Ltd. |
|
|
|
|
|
1329449 |
2.4 % |
07/04/2015 |
RA Capital Management, LLC |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
Peter Kolchinsky |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
Point72 Capital Advisors, Inc. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
EverPoint Asset Management, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
Steven A. Cohen |
United States |
0 |
6664 |
0 |
6664 |
6664 |
0.1 % |
17/02/2015 |
Cubist Systematic Strategies, LLC |
Delaware |
0 |
6664 |
0 |
6664 |
6664 |
0.1 % |
17/02/2015 |
Point72 Asset Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
BlackRock, Inc. |
Delaware |
3277356 |
0 |
3402358 |
0 |
3402358 |
6.2 % |
02/02/2015 |
Bridger Management LLC |
Delaware |
0 |
2984183 |
0 |
2984183 |
2984183 |
5.5 % |
23/01/2015 |
Roberto Mignone |
United States |
0 |
2984183 |
0 |
2984183 |
2984183 |
5.5 % |
23/01/2015 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
2383790 |
0 |
2383790 |
4.502 % |
10/11/2014 |
Abigail P. Johnson |
United States of America |
0 |
0 |
2383790 |
0 |
2383790 |
4.502 % |
10/11/2014 |
FMR LLC |
Delaware |
1000 |
0 |
2383790 |
0 |
2383790 |
4.502 % |
10/11/2014 |
QVT Financial LP |
Delaware |
0 |
4030882 |
0 |
4030882 |
4030882 |
7.62 % |
14/10/2014 |
QVT Associates GP LLC |
Delaware |
0 |
4030882 |
0 |
4030882 |
4030882 |
7.62 % |
14/10/2014 |
QVT Fund V LP |
Cayman Islands |
0 |
3122452 |
0 |
3122452 |
3122452 |
5.9 % |
14/10/2014 |
QVT Financial GP LLC |
Delaware |
0 |
4030882 |
0 |
4030882 |
4030882 |
7.62 % |
14/10/2014 |
Austin W. Marxe, David M. Greenhouse and Adam C. Stettner |
00 |
2 |
|
0 |
1686831 |
0 |
3.2 % |
08/08/2014 |
I.R.S. IDENTIFICATION NO. OF ABOVE PERSON |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/04/2014 |
Israel A. Englander |
United States |
0 |
2219372 |
0 |
2219372 |
2219372 |
4.9 % |
08/04/2014 |
Millennium Management LLC |
Delaware |
0 |
2219372 |
0 |
2219372 |
2219372 |
4.9 % |
08/04/2014 |
Integrated Core Strategies |
Delaware |
0 |
1337198 |
0 |
1337198 |
1337198 |
3 % |
08/04/2014 |
ICS Opportunities, Ltd. |
Cayman Islands |
0 |
877374 |
0 |
877374 |
877374 |
1.9 % |
08/04/2014 |
Millennium International Management GP LLC |
Delaware |
0 |
882174 |
0 |
882174 |
882174 |
1.9 % |
08/04/2014 |
Millennium International Management LP |
Delaware |
0 |
882174 |
0 |
882174 |
882174 |
1.9 % |
08/04/2014 |
Integrated Assets, Ltd. |
Cayman Islands |
0 |
4800 |
0 |
4800 |
4800 |
0 % |
08/04/2014 |
Edward C. Johnson 3d |
United States of America |
0 |
0 |
5029178 |
0 |
5029178 |
11.292 % |
10/03/2014 |
FMR LLC |
Delaware |
0 |
0 |
5029178 |
0 |
5029178 |
11.292 % |
10/03/2014 |
QVT Associates GP LLC |
Delaware |
0 |
2047782 |
0 |
2047782 |
2047782 |
5.29 % |
14/02/2014 |
QVT Financial LP |
Delaware |
0 |
2047782 |
0 |
2047782 |
2047782 |
5.29 % |
14/02/2014 |
QVT Financial GP LLC |
Delaware |
0 |
2047782 |
0 |
2047782 |
2047782 |
5.29 % |
14/02/2014 |
Austin W. Marxe, David M. Greenhouse and Adam C. Stettner |
00 |
2 |
|
0 |
4371595 |
0 |
9.99 % |
12/02/2014 |
Camber Capital Management LLC |
Camber Capital Management LLC Massachusetts |
0 |
1500000 |
0 |
1500000 |
1500000 |
3.88 % |
03/02/2014 |
Stephen DuBois N/A |
Stephen DuBois United States |
0 |
1500000 |
0 |
1500000 |
1500000 |
3.88 % |
03/02/2014 |
Sabby Management, LLC |
Delaware USA |
0 |
653900 |
0 |
653900 |
653900 |
1.69 % |
16/01/2014 |
Hal Mintz |
USA |
0 |
653900 |
0 |
653900 |
653900 |
1.69 % |
16/01/2014 |
Sabby Healthcare Volatility Master Fund, Ltd. |
Cayman Islands |
0 |
653900 |
0 |
653900 |
653900 |
1.69 % |
16/01/2014 |
RA Capital Management, LLC |
Massachusetts |
0 |
3653992 |
0 |
3653992 |
3653992 |
9.9 % |
14/11/2013 |
Peter Kolchinsky |
United States |
0 |
3653992 |
0 |
3653992 |
3653992 |
9.9 % |
14/11/2013 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
2923193 |
0 |
2923193 |
2923193 |
7.9 % |
14/11/2013 |
QVT Financial GP LLC |
Delaware |
0 |
2047781 |
0 |
2047781 |
2047781 |
5.64 % |
18/10/2013 |
QVT Financial LP |
Delaware |
0 |
2047781 |
0 |
2047781 |
2047781 |
5.64 % |
18/10/2013 |
QVT Associates GP LLC |
Delaware |
0 |
2047781 |
0 |
2047781 |
2047781 |
5.64 % |
18/10/2013 |
Ridgeback Capital Investments Ltd. |
Cayman Islands |
0 |
1817717 |
0 |
1817717 |
1817717 |
5 % |
16/10/2013 |
Ridgeback Capital Management LP |
Delaware |
0 |
1817717 |
0 |
1817717 |
1817717 |
5 % |
16/10/2013 |
Ridgeback Capital Investments L.P. |
Cayman Islands |
0 |
1817717 |
0 |
1817717 |
1817717 |
5 % |
16/10/2013 |
S.A.C. Capital Advisors, L.P. |
Delaware |
0 |
1433050 |
0 |
1433050 |
1433050 |
3.9 % |
15/10/2013 |
Steven A. Cohen |
United States |
0 |
1883050 |
0 |
1883050 |
1883050 |
5.2 % |
15/10/2013 |
Sigma Capital Management, LLC |
Delaware |
0 |
450000 |
0 |
450000 |
450000 |
1.2 % |
15/10/2013 |
S.A.C. Capital Advisors, Inc. |
Delaware |
0 |
1433050 |
0 |
1433050 |
1433050 |
3.9 % |
15/10/2013 |
Sabby Management, LLC |
Delaware USA |
0 |
2188792 |
0 |
2188792 |
2188792 |
6.99 % |
13/05/2013 |
Sabby Healthcare Volatility Master Fund, Ltd. |
Cayman Islands |
0 |
2188792 |
0 |
2188792 |
2188792 |
6.99 % |
13/05/2013 |
Hal Mintz |
USA |
0 |
2188792 |
0 |
2188792 |
2188792 |
6.99 % |
13/05/2013 |
RA Capital Management, LLC |
Massachusetts |
0 |
31274011 |
0 |
31274011 |
31274011 |
9.9 % |
09/05/2013 |
RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
25019212 |
0 |
25019212 |
25019212 |
8 % |
09/05/2013 |
Peter Kolchinsky |
United States |
0 |
31274011 |
0 |
31274011 |
31274011 |
9.9 % |
09/05/2013 |
Stephen DuBois N/A |
Stephen DuBois United States |
0 |
3114754 |
0 |
3114754 |
3114754 |
9.9 % |
09/05/2013 |
Camber Capital Management LLC |
Camber Capital Management LLC Massachusetts |
0 |
3114754 |
0 |
3114754 |
3114754 |
9.9 % |
09/05/2013 |
Sabby Healthcare Volatility Master Fund, Ltd. |
Cayman Islands |
0 |
760484 |
0 |
760484 |
760484 |
4.86 % |
28/01/2013 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
135870 |
0 |
135870 |
135870 |
0.87 % |
28/01/2013 |
Sabby Management, LLC |
Delaware USA |
0 |
780643 |
0 |
780643 |
780643 |
4.99 % |
28/01/2013 |
Hal Mintz |
USA |
0 |
780643 |
0 |
780643 |
780643 |
4.99 % |
28/01/2013 |
Roche Holding Ltd |
Switzerland |
0 |
0 |
0 |
0 |
0 |
0 % |
15/01/2013 |
Roche Finance Ltd |
Switzerland |
0 |
0 |
0 |
0 |
0 |
0 % |
15/01/2013 |
Hal Mintz |
USA |
0 |
1086956 |
0 |
1086956 |
1086956 |
8.01 % |
16/08/2012 |
Sabby Management, LLC |
Delaware USA |
0 |
1086956 |
0 |
1086956 |
1086956 |
8.01 % |
16/08/2012 |
Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
181160 |
0 |
181160 |
181160 |
1.33 % |
16/08/2012 |
Sabby Healthcare Volatility Master Fund, Ltd. |
Cayman Islands |
0 |
905796 |
0 |
905796 |
905796 |
6.67 % |
16/08/2012 |
Roche Finance Ltd |
Switzerland |
0 |
9017021 |
0 |
9017021 |
9017021 |
8.6 % |
28/10/2011 |
Roche Holding Ltd |
Switzerland |
0 |
9017021 |
0 |
9017021 |
9017021 |
8.6 % |
28/10/2011 |