| Avoro Capital Advisors LLC |
Delaware |
8888888 |
0 |
8888888 |
0 |
8888888 |
7.2 % |
14/11/2024 |
| Behzad Aghazadeh |
Delaware |
8888888 |
0 |
8888888 |
0 |
8888888 |
7.2 % |
14/11/2024 |
| STATE STREET CORPORATION |
MA |
0 |
5936957 |
0 |
0 |
6354331 |
5.1 % |
16/10/2024 |
| (1) BlackRock, Inc. |
Delaware |
0 |
0 |
0 |
0 |
12710631 |
12 % |
20/01/2023 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
191955 |
9358719 |
281424 |
9640143 |
9.22 % |
09/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
11860689 |
0 |
12008063 |
0 |
12008063 |
11.5 % |
27/01/2022 |
| (1) BlackRock, Inc. |
Delaware |
11872190 |
0 |
12008063 |
0 |
12008063 |
11.5 % |
25/01/2022 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
0 |
231805 |
8968990 |
312561 |
9281551 |
9.03 % |
10/02/2021 |
| (1) BlackRock, Inc. |
Delaware |
12403468 |
0 |
12563132 |
0 |
12563132 |
12.2 % |
26/01/2021 |
| S |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Investments, LP |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| STATE STREET CORPORATION |
|
0 |
0 |
0 |
4124470 |
4124470 |
4.12 % |
13/02/2020 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
196261 |
17849 |
9594203 |
203304 |
9797507 |
9.78 % |
11/02/2020 |
| (1) BlackRock, Inc. |
Delaware |
12149645 |
0 |
12360958 |
0 |
12360958 |
12.3 % |
04/02/2020 |
| The Vanguard Group - 23-1945930 |
Pennsylvania |
198567 |
16160 |
10639170 |
205401 |
10844571 |
11.37 % |
10/10/2019 |
| (1) BlackRock, Inc. |
Delaware |
6999384 |
0 |
7184621 |
0 |
7184621 |
7.8 % |
07/02/2019 |
| OppenheimerFunds, Inc. |
Colorado |
0 |
7806082 |
0 |
0 |
7806082 |
8.46 % |
14/01/2019 |
| S |
Delaware |
0 |
4358067 |
0 |
0 |
4358067 |
5.02 % |
14/05/2018 |
| S |
Delaware |
0 |
4358067 |
0 |
0 |
4358067 |
5.02 % |
14/05/2018 |
| OppenheimerFunds, Inc. |
Colorado |
0 |
6300000 |
0 |
0 |
6300000 |
8.42 % |
06/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
2464607 |
0 |
0 |
0 |
2464607 |
3.3 % |
10/07/2017 |
| (1) BlackRock, Inc. |
Delaware |
4954660 |
0 |
5093721 |
0 |
5093721 |
6.9 % |
19/01/2017 |
| Baker Bros. Advisors (GP) LLC |
Delaware |
3680499 |
0 |
3680499 |
0 |
3680499 |
5.9 % |
16/02/2016 |
| Felix J. Baker |
Delaware |
3680499 |
0 |
3680499 |
0 |
3680499 |
5.9 % |
16/02/2016 |
| Julian C. Baker |
Delaware |
3680499 |
0 |
3680499 |
0 |
3680499 |
5.9 % |
16/02/2016 |
| Baker Bros. Advisors LP |
Delaware |
3680499 |
0 |
3680499 |
0 |
3680499 |
5.9 % |
16/02/2016 |
| Oppenheimer Global Opportunities Fund |
Colorado |
0 |
3000000 |
0 |
0 |
3000000 |
5.04 % |
01/02/2016 |
| OppenheimerFunds, Inc. |
Colorado |
0 |
3000000 |
0 |
0 |
3000000 |
5.04 % |
01/02/2016 |
| (1) BlackRock, Inc. |
Delaware |
3951764 |
0 |
4085277 |
0 |
4085277 |
6.9 % |
25/01/2016 |
| Peter Kolchinsky |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
| RA Capital Management,
LLC |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
| RA Capital Healthcare Fund, L.P. |
Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
6664 |
0 |
0 |
6664 |
4 % |
17/02/2015 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
| EverPoint Asset Management, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2015 |
| Steven A. Cohen |
Delaware |
0 |
6664 |
0 |
0 |
6664 |
4 % |
17/02/2015 |
| (1) BlackRock, Inc. |
Delaware |
3277356 |
0 |
3402358 |
0 |
3402358 |
6.2 % |
02/02/2015 |
| 10. |
Delaware |
0 |
3122452 |
0 |
3122452 |
3122452 |
5.9 % |
14/10/2014 |
| 10. |
Delaware |
0 |
4030882 |
0 |
4030882 |
4030882 |
7.62 % |
14/10/2014 |
| 10. |
Delaware |
0 |
4030882 |
0 |
4030882 |
4030882 |
7.62 % |
14/10/2014 |
| 10. |
Delaware |
0 |
4030882 |
0 |
4030882 |
4030882 |
7.62 % |
14/10/2014 |
| Sigma Capital Management, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/04/2014 |
| Point72 Capital Advisors, Inc. (formerly S.A.C. Capital Advisors, Inc.) |
Delaware |
0 |
2790000 |
0 |
0 |
2790000 |
6.2 % |
09/04/2014 |
| Steven A. Cohen |
Delaware |
0 |
3225000 |
0 |
0 |
3225000 |
7.1 % |
09/04/2014 |
| EverPoint Asset Management, LLC |
Delaware |
0 |
435000 |
0 |
0 |
435000 |
1 % |
09/04/2014 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
2790000 |
0 |
0 |
2790000 |
6.2 % |
09/04/2014 |
| S.A.C. Capital Advisors, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
09/04/2014 |
| Millennium Management LLC |
Delaware |
0 |
2219372 |
0 |
2219372 |
2219372 |
4.9 % |
08/04/2014 |
| Integrated Core Strategies (US) LLC |
Delaware |
0 |
1337198 |
0 |
1337198 |
1337198 |
3 % |
08/04/2014 |
| ICS Opportunities, Ltd. |
Delaware |
0 |
877374 |
0 |
877374 |
877374 |
1.9 % |
08/04/2014 |
| Integrated Assets, Ltd. |
Delaware |
0 |
4800 |
0 |
4800 |
4800 |
0 % |
08/04/2014 |
| Millennium International Management LP |
Delaware |
0 |
882174 |
0 |
882174 |
882174 |
1.9 % |
08/04/2014 |
| Millennium International Management GP LLC |
Delaware |
0 |
882174 |
0 |
882174 |
882174 |
1.9 % |
08/04/2014 |
| Israel A. Englander |
Delaware |
0 |
2219372 |
0 |
2219372 |
2219372 |
4.9 % |
08/04/2014 |
| Ridgeback Capital Management LP 42-1684320 |
Delaware |
0 |
791306 |
0 |
0 |
791306 |
0.2 % |
14/02/2014 |
| Ridgeback Capital Investments L.P. 00-0000000 |
Cayman Islands |
0 |
791306 |
0 |
0 |
791306 |
0.2 % |
14/02/2014 |
| Ridgeback Capital Investments Ltd. 00-0000000 |
Cayman Islands |
0 |
791306 |
0 |
0 |
791306 |
0.2 % |
14/02/2014 |
| S.A.C. Capital Advisors, Inc. |
Delaware |
0 |
1500000 |
0 |
0 |
1500000 |
3.9 % |
14/02/2014 |
| S.A.C. Capital Advisors, L.P. |
Delaware |
0 |
1500000 |
0 |
0 |
1500000 |
3.9 % |
14/02/2014 |
| Steven A. Cohen |
United States |
0 |
2000000 |
0 |
0 |
2000000 |
5.2 % |
14/02/2014 |
| Sigma Capital Management, LLC |
Delaware |
0 |
500000 |
0 |
0 |
500000 |
1.3 % |
14/02/2014 |
| 2. |
Delaware |
0 |
2047782 |
0 |
2047782 |
2047782 |
5.29 % |
14/02/2014 |
| 2. |
Delaware |
0 |
2047782 |
0 |
2047782 |
2047782 |
5.29 % |
14/02/2014 |
| 2. |
Delaware |
0 |
2047782 |
0 |
2047782 |
2047782 |
5.29 % |
14/02/2014 |
| T. ROWE PRICE ASSOCIATES, INC. |
Camber Capital Management LLC Massachusetts |
0 |
1500000 |
0 |
1500000 |
2661528 |
9.9 % |
03/02/2014 |
| RA Capital Healthcare Fund, L.P. |
Massachusetts |
0 |
2923193 |
0 |
0 |
2923193 |
7.9 % |
14/11/2013 |
| Peter Kolchinsky |
Massachusetts |
0 |
3653992 |
0 |
0 |
3653992 |
9.9 % |
14/11/2013 |
| RA Capital Management, LLC |
Massachusetts |
0 |
3653992 |
0 |
0 |
3653992 |
9.9 % |
14/11/2013 |
| Ridgeback Capital Investments L.P. 00-0000000 |
Cayman Islands |
0 |
1817717 |
0 |
0 |
1817717 |
5 % |
16/10/2013 |
| Ridgeback Capital Management LP |
Cayman Islands |
0 |
1817717 |
0 |
0 |
1817717 |
5 % |
16/10/2013 |
| Ridgeback Capital Investments Ltd. 00-0000000 |
Cayman Islands |
0 |
1817717 |
0 |
0 |
1817717 |
5 % |
16/10/2013 |
| Steven A. Cohen |
Delaware |
0 |
1883050 |
0 |
0 |
1883050 |
5.2 % |
15/10/2013 |
| S.A.C. Capital Advisors, L.P. |
Delaware |
0 |
1433050 |
0 |
0 |
1433050 |
3.9 % |
15/10/2013 |
| Sigma Capital Management, LLC |
Delaware |
0 |
450000 |
0 |
0 |
450000 |
1.2 % |
15/10/2013 |
| S.A.C. Capital Advisors, Inc. |
Delaware |
0 |
1433050 |
0 |
0 |
1433050 |
3.9 % |
15/10/2013 |
| GAMCO Investors, Inc. |
USA |
0 |
2188792 |
0 |
2188792 |
338812 |
5.51 % |
13/05/2013 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
2501921 |
0 |
2501921 |
2501921 |
8 % |
09/05/2013 |
| RA Capital Management, LLC |
Delaware |
0 |
3127401 |
0 |
3127401 |
3127401 |
9.9 % |
09/05/2013 |
| Peter Kolchinsky |
Delaware |
0 |
3127401 |
0 |
3127401 |
3127401 |
9.9 % |
09/05/2013 |
| Roche Finance Ltd |
Switzerland |
0 |
0 |
0 |
0 |
0 |
0 % |
15/01/2013 |
| Roche Holding Ltd |
Switzerland |
0 |
0 |
0 |
0 |
0 |
0 % |
15/01/2013 |
| Roche Finance Ltd |
Switzerland |
0 |
9017021 |
0 |
9017021 |
9017021 |
8.6 % |
28/10/2011 |
| Roche Holding Ltd |
Switzerland |
0 |
9017021 |
0 |
9017021 |
9017021 |
8.6 % |
28/10/2011 |
| FMR LLC |
Delaware |
0 |
0 |
1342577 |
0 |
1342577 |
3.102 % |
11/05/2009 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
1342577 |
0 |
1342577 |
3.102 % |
11/05/2009 |
| FMR LLC |
Delaware |
0 |
0 |
3602916 |
0 |
3602916 |
8.324 % |
17/02/2009 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
3602916 |
0 |
3602916 |
8.324 % |
17/02/2009 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
5062607 |
0 |
5062607 |
12.998 % |
14/02/2008 |
| FMR LLC |
Delaware |
0 |
0 |
5062607 |
0 |
5062607 |
12.998 % |
14/02/2008 |
| JGD
Management Corp.
EIN: 13-3633324 |
Delaware |
3698290 |
0 |
3698290 |
0 |
3698290 |
9.3 % |
18/01/2008 |
| FMR Corp. |
Delaware |
0 |
0 |
4240931 |
0 |
4240931 |
11.776 % |
11/06/2007 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
4240931 |
0 |
4240931 |
11.776 % |
11/06/2007 |
| Corporation |
America |
0 |
0 |
0 |
0 |
993925 |
6.3 % |
29/04/2005 |
| Knott |
America |
0 |
0 |
0 |
0 |
993925 |
6.3 % |
29/04/2005 |