AVDL

Avadel Pharmaceuticals plc AVDL

Bénéficiaire Individuel

Déclarant Citoyenneté ou lieu d'organisation Pouvoir de vote unique Pouvoir de vote partagé Pouvoir de disposition unique Pouvoir de disposition partagé Montant en propriété effective Pourcentage détenu Date d'achat
Roderick Wong, M.D. United States 0 0 0 0 0 0 % 14/11/2024
RTW Investments, LP Delaware 0 0 0 0 0 0 % 14/11/2024
BlackRock, Inc. Delaware 0 0 5257004 0 5257004 5.5 % 24/10/2024
Roderick Wong, M.D. United States 0 9196186 0 9196186 9196186 9.99 % 14/02/2024
RTW Investments, LP Delaware 0 9196186 0 9196186 9196186 9.99 % 14/02/2024
Janus Henderson Group plc EIN Jersey, Channel Islands 0 11125330 0 11125330 11125330 12.4 % 13/02/2024
Jeffrey L. Gendell United States 70000 5615350 70000 5615350 5685350 6.33 % 13/02/2024
Tontine Capital Overseas Master Fund II, L.P. Delaware 0 3539782 0 3539782 3539782 3.94 % 13/02/2024
Tontine Asset Associates, LLC Delaware 0 3539782 0 3539782 3539782 3.94 % 13/02/2024
Polar Capital LLP United Kingdom 6751782 0 6751782 0 0 7.51 % 13/02/2024
Polar Capital Holdings Plc United Kingdom 6751782 0 6751782 0 0 7.51 % 13/02/2024
Kevin Kotler United States of America 3716242 0 3716242 0 3716242 4.1 % 12/02/2024
Kevin Kotler United States of America 3122100 0 3122100 0 3122100 5.1 % 09/03/2023
Kevin Kotler United States of America 3122100 0 3122100 0 3122100 5.1 % 09/03/2023
Tontine Asset Associates, LLC Delaware 0 3294817 0 3294817 3294817 5.33 % 14/02/2023
Jeffrey L. Gendell United States 70000 5120605 70000 5120605 5190605 8.4 % 14/02/2023
Tontine Capital Overseas Master Fund II, L.P. Delaware 0 3294817 0 3294817 3294817 5.33 % 14/02/2023
RTW Investments, LP Delaware 0 5741939 0 5741939 5741939 9.3 % 14/02/2023
Roderick Wong United States 0 5741939 0 5741939 5741939 9.3 % 14/02/2023
Vivo Opportunity, LLC Delaware 2251663 0 2251663 0 2251663 3.6 % 13/02/2023
Vivo Capital Fund IX, L.P. Delaware 502432 0 502432 0 502432 0.8 % 13/02/2023
Kevin Kotler United States of America 2856990 0 2856990 0 2856990 4.6 % 13/02/2023
Kevin Kotler United States of America 3440212 0 3440212 0 3440212 5.8 % 06/06/2022
Tontine Asset Associates, LLC Delaware 0 2906665 0 2906665 2906665 4.92 % 03/06/2022
Tontine Capital Overseas Master Fund II, L.P. Delaware 0 2906665 0 2906665 2906665 4.92 % 03/06/2022
Jeffrey L. Gendell United States 0 4174982 0 4174982 4174982 7.07 % 03/06/2022
Tontine Asset Associates, LLC Delaware 0 2906665 0 2906665 2906665 4.92 % 03/06/2022
Tontine Capital Overseas Master Fund II, L.P. Delaware 0 2906665 0 2906665 2906665 4.92 % 03/06/2022
Jeffrey L. Gendell United States 0 4174982 0 4174982 4174982 7.07 % 03/06/2022
Polar Capital Holdings Plc United Kingdom 0 2794673 0 2794673 0 4.8 % 14/02/2022
Polar Capital LLP United Kingdom 0 2794673 0 2794673 0 4.8 % 14/02/2022
Roderick Wong United States 0 5810140 0 5810140 5810140 9.99 % 14/02/2022
RTW Investments, LP Delaware 0 5810140 0 5810140 5810140 9.99 % 14/02/2022
Vivo Capital Fund IX, L.P. Delaware 535817 0 535817 0 535817 0.9 % 11/02/2022
Vivo Opportunity, LLC Delaware 2401276 0 2401276 0 2401276 4.1 % 11/02/2022
Behzad Aghazadeh United States 1670000 0 1670000 0 1670000 2.9 % 11/02/2022
Avoro Capital Advisors LLC Delaware 1670000 0 1670000 0 1670000 2.9 % 11/02/2022
CO-GP, LLC Delaware 1672086 2599633 2599633 4.43 % 08/02/2022
Brandes Worldwide Holdings, L.P. Delaware 1672086 2599633 2599633 4.43 % 08/02/2022
Brandes Investment Partners, L.P. Delaware 1672086 2599633 2599633 4.43 % 08/02/2022
Brandes Worldwide Holdings, L.P. Delaware 1672086 2599633 2599633 4.43 % 08/02/2022
CO-GP, LLC Delaware 1672086 2599633 2599633 4.43 % 08/02/2022
Brandes Investment Partners, L.P. Delaware 1672086 2599633 2599633 4.43 % 08/02/2022
Glenn Carlson USA 1672086 2599633 2599633 4.43 % 08/02/2022
Glenn Carlson USA 1672086 2599633 2599633 4.43 % 08/02/2022
Cowen and Company, LLC USA 0 0 0 0 % 21/01/2022
Cowen Financial Products USA 3732778 3732778 3732778 6.37 % 21/01/2022
Cowen and Company, LLC USA 0 0 0 0 % 21/01/2022
Cowen Financial Products USA 3732778 3732778 3732778 6.37 % 21/01/2022
Cowen Financial Products LLC USA 3041624 3041624 3041624 5.18 % 12/11/2021
Cowen Financial Products LLC USA 3041624 3041624 3041624 5.18 % 12/11/2021
Cowen and Company, LLC USA 42000 42000 42000 0.07 % 12/11/2021
Cowen and Company, LLC USA 42000 42000 42000 0.07 % 12/11/2021
Polar Capital Holdings Plc United Kingdom 0 3027705 0 3027705 0 5.2 % 16/02/2021
Polar Capital LLP United Kingdom 0 3027705 0 3027705 0 5.2 % 16/02/2021
RTW Investments, LP Delaware 0 5387513 0 5387513 5387513 9.26 % 12/02/2021
Roderick Wong United States of America 0 5387513 0 5387513 5387513 9.26 % 12/02/2021
RTW Master Fund, Ltd. Cayman Islands 0 3811140 0 3811140 3811140 6.55 % 12/02/2021
Avoro Capital Advisors LLC Delaware 4365000 0 4365000 0 4365000 7.5 % 12/02/2021
Behzad Aghazadeh United States 4365000 0 4365000 0 4365000 7.5 % 12/02/2021
Glenn Carlson USA 1862736 2961878 2961878 5.08 % 11/02/2021
Brandes Worldwide Holdings, L.P. Delaware 1862736 2961878 2961878 5.08 % 11/02/2021
CO-GP, LLC. Delaware 1862736 2961878 2961878 5.08 % 11/02/2021
Brandes Investment Partners, L.P. Delaware 1862736 2961878 2961878 5.08 % 11/02/2021
Glenn Carlson USA 1862736 2961878 2961878 5.08 % 11/02/2021
Brandes Worldwide Holdings, L.P. Delaware 1862736 2961878 2961878 5.08 % 11/02/2021
CO-GP, LLC. Delaware 1862736 2961878 2961878 5.08 % 11/02/2021
Brandes Investment Partners, L.P. Delaware 1862736 2961878 2961878 5.08 % 11/02/2021
Vivo Opportunity, LLC Delaware 2882824 0 2882824 0 2882824 6.2 % 04/03/2020
Vivo Capital Fund IX, L.P. Delaware 643269 0 643269 0 643269 1.4 % 04/03/2020
RTW Master Fund, Ltd. Cayman Islands 0 2479370 0 2479370 2479370 6.62 % 14/02/2020
Roderick Wong United States of America 0 3401434 0 3401434 3401434 9.08 % 14/02/2020
Roderick Wong United States of America 0 3401434 0 3401434 3401434 9.08 % 14/02/2020
RTW Investments, LP Delaware 0 3401434 0 3401434 3401434 9.08 % 14/02/2020
RTW Master Fund, Ltd. Cayman Islands 0 2479370 0 2479370 2479370 6.62 % 14/02/2020
RTW Investments, LP Delaware 0 3401434 0 3401434 3401434 9.08 % 14/02/2020
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 1029012 0 1029012 1029012 2.75 % 13/02/2020
Broadfin Capital, LLC Delaware 0 1029012 0 1029012 1029012 2.75 % 13/02/2020
Kevin Kotler United States of America 0 1029012 0 1029012 1029012 2.75 % 13/02/2020
S Breaking Stick Holdings, LLC Delaware 0 0 0 0 0 0 % 13/02/2020
James E. Flynn United States 0 0 0 0 0 0 % 13/02/2020
Breaking Stick Holdings, LLC Delaware 0 0 0 0 0 0 % 13/02/2020
S James E. Flynn United States 0 0 0 0 0 0 % 13/02/2020
Deerfield Private Design Fund II, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
Deerfield Private Design International II, L.P. British Virgin Islands 0 0 0 0 0 0 % 13/02/2020
Deerfield Management Company, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
S Deerfield Private Design International II, L.P. British Virgin Islands 0 0 0 0 0 0 % 13/02/2020
S Deerfield Mgmt, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
Deerfield Mgmt, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
S Deerfield Private Design Fund II, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
S Deerfield Management Company, L.P. Delaware 0 0 0 0 0 0 % 13/02/2020
Brandes Worldwide Holdings, L.P. Delaware 2662920 3651948 3651948 9.75 % 07/01/2020
Brandes Investment Partners, L.P. Delaware 2662920 3651948 3651948 9.75 % 07/01/2020
CO-GP, LLC. Delaware 2662920 3651948 3651948 9.75 % 07/01/2020
Brandes Worldwide Holdings, L.P. Delaware 2662920 3651948 3651948 9.75 % 07/01/2020
Glenn Carlson USA 2662920 3651948 3651948 9.75 % 07/01/2020
Brandes Investment Partners, L.P. Delaware 2662920 3651948 3651948 9.75 % 07/01/2020
Glenn Carlson USA 2662920 3651948 3651948 9.75 % 07/01/2020
CO-GP, LLC. Delaware 2662920 3651948 3651948 9.75 % 07/01/2020
RTW Investments, LP Delaware 0 3396155 0 3396155 3396155 9.07 % 30/12/2019
Roderick Wong United States of America 0 3396155 0 3396155 3396155 9.07 % 30/12/2019
RTW Master Fund, Ltd. Cayman Islands 0 2475390 0 2475390 2475390 6.61 % 30/12/2019
Roderick Wong United States of America 0 3396155 0 3396155 3396155 9.07 % 30/12/2019
RTW Investments, LP Delaware 0 3396155 0 3396155 3396155 9.07 % 30/12/2019
RTW Master Fund, Ltd. Cayman Islands 0 2475390 0 2475390 2475390 6.61 % 30/12/2019
Glenn Carlson USA 3420624 4440050 4440050 11.86 % 05/12/2019
Glenn Carlson USA 3420624 4440050 4440050 11.86 % 05/12/2019
Brandes Worldwide Holdings, L.P. Delaware 3420624 4440050 4440050 11.86 % 05/12/2019
CO-GP, LLC. Delaware 3420624 4440050 4440050 11.86 % 05/12/2019
Brandes Investment Partners, L.P. Delaware 3420624 4440050 4440050 11.86 % 05/12/2019
Brandes Investment Partners, L.P. Delaware 3420624 4440050 4440050 11.86 % 05/12/2019
CO-GP, LLC. Delaware 3420624 4440050 4440050 11.86 % 05/12/2019
Brandes Worldwide Holdings, L.P. Delaware 3420624 4440050 4440050 11.86 % 05/12/2019
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 3102673 0 3102673 3102673 8.3 % 04/10/2019
Broadfin Capital, LLC Delaware 0 3102673 0 3102673 3102673 8.3 % 04/10/2019
Kevin Kotler United States of America 0 3102673 0 3102673 3102673 8.3 % 04/10/2019
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 3102673 0 3102673 3102673 8.3 % 04/10/2019
Broadfin Capital, LLC Delaware 0 3102673 0 3102673 3102673 8.3 % 04/10/2019
Kevin Kotler United States of America 0 3102673 0 3102673 3102673 8.3 % 04/10/2019
Perceptive Life Sciences Master Fund, Ltd. Cayman Islands 0 14860 0 14860 14860 0.1 % 14/02/2019
Perceptive Advisors LLC Delaware 0 14860 0 14860 14860 0.1 % 14/02/2019
Joseph Edelman United States of America 0 14860 0 14860 14860 0.1 % 14/02/2019
Breaking Stick Holdings, LLC Delaware 0 602762 0 602762 602762 1.63 % 12/02/2019
Deerfield Management Company, L.P. Delaware 0 2722241 0 2722241 2722241 7.36 % 12/02/2019
S Breaking Stick Holdings, LLC Delaware 0 602762 0 602762 602762 1.63 % 12/02/2019
S Deerfield Management Company, L.P. Delaware 0 2722241 0 2722241 2722241 7.36 % 12/02/2019
S Deerfield Special Situations Fund. L.P. Delaware 0 0 0 0 0 0 % 12/02/2019
S Deerfield Mgmt, L.P. Delaware 0 2722241 0 2722241 2722241 7.36 % 12/02/2019
Deerfield Private Design International II, L.P. British Virgin Islands 0 1734564 0 1734564 1734564 4.69 % 12/02/2019
Deerfield Private Design Fund II, L.P. Delaware 0 1590439 0 1590439 1590439 4.3 % 12/02/2019
S Deerfield Private Design International II, L.P. British Virgin Islands 0 1734564 0 1734564 1734564 4.69 % 12/02/2019
Deerfield Special Situations Fund. L.P. Delaware 0 0 0 0 0 0 % 12/02/2019
Deerfield Mgmt, L.P. Delaware 0 2722241 0 2722241 2722241 7.36 % 12/02/2019
S James E. Flynn United States America 0 2722241 0 2722241 2722241 7.36 % 12/02/2019
S Deerfield Private Design Fund II, L.P. Delaware 0 1590439 0 1590439 1590439 4.3 % 12/02/2019
James E. Flynn United States of America 0 2722241 0 2722241 2722241 7.36 % 12/02/2019
CO-GP, LLC. Delaware 7119054 7119054 19.23 % 10/01/2019
Glenn Carlson USA 7119054 7119054 19.23 % 10/01/2019
Glenn Carlson USA 7119054 7119054 19.23 % 10/01/2019
Brandes Worldwide Holdings, L.P. Delaware 7119054 7119054 19.23 % 10/01/2019
CO-GP, LLC. Delaware 7119054 7119054 19.23 % 10/01/2019
Brandes Investment Partners, L.P. Delaware 7119054 7119054 19.23 % 10/01/2019
Brandes Worldwide Holdings, L.P. Delaware 7119054 7119054 19.23 % 10/01/2019
Brandes Investment Partners, L.P. Delaware 7119054 7119054 19.23 % 10/01/2019
Brandes Worldwide Holdings, L.P. Number of 0 6177794 0 6177794 6177794 16.8 % 05/09/2018
CO-GP, LLC. Number of 0 6177794 0 6177794 0 16.8 % 05/09/2018
Brandes Investment Partners, L.P. Number of 0 6177794 0 6177794 6177794 16.8 % 05/09/2018
CO-GP, LLC. Number of 0 6177794 0 6177794 0 16.8 % 05/09/2018
Brandes Worldwide Holdings, L.P. Number of 0 6177794 0 6177794 6177794 16.8 % 05/09/2018
Glenn Carlson Number of 0 6177794 0 6177794 0 16.8 % 05/09/2018
Brandes Investment Partners, L.P. Number of 0 6177794 0 6177794 6177794 16.8 % 05/09/2018
Glenn Carlson Number of 0 6177794 0 6177794 0 16.8 % 05/09/2018
CO-GP, LLC. Number of 0 4297456 0 4808493 0 12.67 % 09/04/2018
Glenn Carlson Number of 0 4297456 0 4808493 0 12.67 % 09/04/2018
Glenn Carlson Number of 0 4297456 0 4808493 0 12.67 % 09/04/2018
Brandes Investment Partners, L.P. Number of 0 4297456 0 4808493 4808493 12.67 % 09/04/2018
Brandes Worldwide Holdings, L.P. Number of 0 4297456 0 4808493 4808493 12.67 % 09/04/2018
CO-GP, LLC. Number of 0 4297456 0 4808493 0 12.67 % 09/04/2018
Brandes Investment Partners, L.P. Number of 0 4297456 0 4808493 4808493 12.67 % 09/04/2018
Brandes Worldwide Holdings, L.P. Number of 0 4297456 0 4808493 4808493 12.67 % 09/04/2018
Armistice Capital, LLC Delaware 0 1836000 0 1836000 1836000 4.8 % 30/03/2018
Armistice Capital Master Fund Ltd. Cayman Islands 0 1836000 0 1836000 1836000 4.8 % 30/03/2018
Armistice Capital, LLC Delaware 0 1836000 0 1836000 1836000 4.8 % 30/03/2018
Steven Boyd United States of America 0 1836000 0 1836000 1836000 4.8 % 30/03/2018
Steven Boyd United States of America 0 1836000 0 1836000 1836000 4.8 % 30/03/2018
Armistice Capital Master Fund Ltd. Cayman Islands 0 1836000 0 1836000 1836000 4.8 % 30/03/2018
Perceptive Advisors LLC Delaware 0 2391841 0 2391841 2391841 6 % 14/02/2018
Perceptive Life Sciences Master Fund, Ltd. Cayman Islands 0 2391841 0 2391841 2391841 6 % 14/02/2018
Joseph Edelman United States America 0 2391841 0 2391841 2391841 6 % 14/02/2018
James E. Flynn United States of America 0 7255494 0 7255494 7255494 9.985 % 14/02/2018
Deerfield Mgmt, L.P. Delaware 0 7255494 0 7255494 7255494 9.985 % 14/02/2018
Deerfield Special Situations Fund. L.P. Delaware 0 1066299 0 1066299 1066299 2.68 % 14/02/2018
Deerfield Private Design Fund II, L.P. Delaware 0 4646365 0 4646365 4646365 9.985 % 14/02/2018
Deerfield Private Design International II, L.P. British Virgin Islands 0 4842830 0 4842830 4842830 9.985 % 14/02/2018
Deerfield Management Company, L.P. Delaware 0 7255494 0 7255494 7255494 9.985 % 14/02/2018
Breaking Stick Holdings, LLC Delaware 0 3300000 0 3300000 3300000 7.66 % 14/02/2018
James E. Flynn United States of America 0 7255494 0 7255494 7255494 9.985 % 14/02/2018
Deerfield Mgmt, L.P. Delaware 0 7255494 0 7255494 7255494 9.985 % 14/02/2018
Deerfield Special Situations Fund. L.P. Delaware 0 1066299 0 1066299 1066299 2.68 % 14/02/2018
Deerfield Private Design Fund II, L.P. Delaware 0 4646365 0 4646365 4646365 9.985 % 14/02/2018
Deerfield Private Design International II, L.P. British Virgin Islands 0 4842830 0 4842830 4842830 9.985 % 14/02/2018
Deerfield Management Company, L.P. Delaware 0 7255494 0 7255494 7255494 9.985 % 14/02/2018
Breaking Stick Holdings, LLC Delaware 0 3300000 0 3300000 3300000 7.66 % 14/02/2018
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 2591721 0 2591721 2591721 6.52 % 13/02/2018
Broadfin Capital, LLC Delaware 0 2591721 0 2591721 2591721 6.52 % 13/02/2018
Kevin Kotler United States of America 0 2591721 0 2591721 2591721 6.52 % 13/02/2018
Janus Capital Management LLC EIN Delaware 0 0 0 0 0 0 % 06/02/2018
Brandes Investment Partners, L.P. Delaware 3298109 3308250 3308250 7.99 % 06/02/2018
Brandes Investment Partners, Inc. California 3298109 3308250 3308250 7.99 % 06/02/2018
Brandes Worldwide Holdings, L.P. Delaware 3298109 3308250 3308250 7.99 % 06/02/2018
Charles H. Brandes USA 3298109 3308250 3308250 7.99 % 06/02/2018
Brandes Investment Partners, L.P. Delaware 3298109 3308250 3308250 7.99 % 06/02/2018
Charles H. Brandes USA 3298109 3308250 3308250 7.99 % 06/02/2018
Brandes Worldwide Holdings, L.P. Delaware 3298109 3308250 3308250 7.99 % 06/02/2018
Brandes Investment Partners, Inc. California 3298109 3308250 3308250 7.99 % 06/02/2018
Joseph Edelman United States of America 0 2241841 0 2241841 2241841 5.4 % 09/11/2017
Perceptive Advisors LLC Delaware 0 2241841 0 2241841 2241841 5.4 % 09/11/2017
Perceptive Life Sciences Master Fund, Ltd. Cayman Islands 0 2241841 0 2241841 2241841 5.4 % 09/11/2017
James E. Flynn United States 0 7372809 0 7372809 7372809 9.985 % 14/02/2017
Deerfield Management Company, L.P. Delaware 0 7372809 0 7372809 7372809 9.985 % 14/02/2017
S Deerfield Mgmt, L.P. Delaware 0 7372809 0 7372809 7372809 9.985 % 14/02/2017
S Deerfield Special Situations Fund. L.P. Delaware 0 1183614 0 1183614 1183614 2.87 % 14/02/2017
S Deerfield Private Design Fund II, L.P. Delaware 0 4646365 0 4646365 4646365 9.985 % 14/02/2017
S Deerfield Private Design International II, L.P. British Virgin Islands 0 4842830 0 4842830 4842830 9.985 % 14/02/2017
S Deerfield Management Company, L.P. Delaware 0 7372809 0 7372809 7372809 9.985 % 14/02/2017
S Breaking Stick Holdings, LLC Delaware 0 3300000 0 3300000 3300000 7.41 % 14/02/2017
S James E. Flynn United States 0 7372809 0 7372809 7372809 9.985 % 14/02/2017
Deerfield Special Situations Fund. L.P. Delaware 0 1183614 0 1183614 1183614 2.87 % 14/02/2017
Deerfield Mgmt, L.P. Delaware 0 7372809 0 7372809 7372809 9.985 % 14/02/2017
Deerfield Private Design Fund II, L.P. Delaware 0 4646365 0 4646365 4646365 9.985 % 14/02/2017
Deerfield Private Design International II, L.P. British Virgin Islands 0 4842830 0 4842830 4842830 9.985 % 14/02/2017
Breaking Stick Holdings, LLC Delaware 0 3300000 0 3300000 3300000 7.41 % 14/02/2017
Janus Capital Management LLC EIN Delaware 2227805 0 2227805 0 2227805 5.5 % 13/02/2017
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 0 0 0 0 0 % 06/01/2017
Broadfin Capital, LLC Delaware 0 0 0 0 0 0 % 06/01/2017
Kevin Kotler United States of America 0 0 0 0 0 0 % 06/01/2017
Broadfin Capital, LLC Delaware 0 4394464 0 4394464 4394464 10.7 % 06/01/2017
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 4394464 0 4394464 4394464 10.7 % 06/01/2017
Kevin Kotler United States of America 0 4394464 0 4394464 4394464 10.7 % 06/01/2017
Broadfin Capital, LLC Delaware 0 4394464 0 4394464 4394464 10.7 % 06/01/2017
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 4394464 0 4394464 4394464 10.7 % 06/01/2017
Kevin Kotler United States of America 0 4394464 0 4394464 4394464 10.7 % 06/01/2017
The Bank of New York Mellon Corporation New York 1818579 0 1818579 0 1818579 4.41 % 11/07/2016
Janus Capital Management LLC EIN Delaware 2197404 0 2197404 0 2197404 5.3 % 08/07/2016
Deerfield Special Situations Fund. L.P. Delaware 0 1183614 0 1183614 1183614 2.87 % 22/03/2016
James E. Flynn United States of America 0 7372809 0 7372809 7372809 9.985 % 22/03/2016
Deerfield Management Company, L.P. Delaware 0 7372809 0 7372809 7372809 9.985 % 22/03/2016
Deerfield Mgmt, L.P. Delaware 0 7372809 0 7372809 7372809 9.985 % 22/03/2016
Deerfield Private Design International II, L.P. British Virgin Islands 0 4842830 0 4842830 4842830 9.985 % 22/03/2016
Breaking Stick Holdings, LLC Delaware 0 3300000 0 3300000 3300000 7.41 % 22/03/2016
Deerfield Private Design Fund II, L.P. Delaware 0 4646365 0 4646365 4646365 9.985 % 22/03/2016
Deerfield Management Company, L.P. Delaware 0 7372809 0 7372809 7372809 10.12 % 18/03/2016
Deerfield Mgmt, L.P. Delaware 0 7372809 0 7372809 7372809 10.12 % 18/03/2016
Deerfield Special Situations Fund. L.P. Delaware 0 1183614 0 1183614 1183614 2.94 % 18/03/2016
Deerfield Private Design Fund II, L.P. Delaware 0 4646365 0 4646365 4646365 9.985 % 18/03/2016
Deerfield Private Design International II, L.P. British Virgin Islands 0 4842830 0 4842830 4842830 9.985 % 18/03/2016
Breaking Stick Holdings, LLC Delaware 0 3300000 0 3300000 3300000 7.58 % 18/03/2016
James E. Flynn United States of America 0 7372809 0 7372809 7372809 10.12 % 18/03/2016
Janus Capital Management LLC EIN Delaware 4318315 0 4318315 0 4318315 10.7 % 16/02/2016
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 4394464 0 4394464 4394464 10.9 % 12/02/2016
Broadfin Capital, LLC Delaware 0 4394464 0 4394464 4394464 10.9 % 12/02/2016
Kevin Kotler United States of America 0 4394464 0 4394464 4394464 10.9 % 12/02/2016
The Bank of New York Mellon Corporation New York 2619872 0 2593276 26596 2619872 6.52 % 26/01/2016
James E. Flynn United States of America 0 7372809 0 7372809 7372809 9.985 % 04/01/2016
Deerfield Mgmt, L.P. Delaware 0 7372809 0 7372809 7372809 9.985 % 04/01/2016
Deerfield Management Company, L.P. Delaware 0 7372809 0 7372809 7372809 9.985 % 04/01/2016
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 0 0 0 0 0 % 04/01/2016
Breaking Stick Holdings, LLC Delaware 0 3300000 0 3300000 3300000 7.43 % 04/01/2016
Deerfield Private Design Fund II, L.P. Delaware 0 4646365 0 4646365 4646365 9.985 % 04/01/2016
Deerfield Private Design International II, L.P. British Virgin Islands 0 4842830 0 4842830 4842830 9.985 % 04/01/2016
Deerfield Special Situations Fund. L.P. Delaware 0 1183614 0 1183614 1183614 2.88 % 04/01/2016
Janus Capital Management LLC EIN Delaware 4341515 0 4341515 0 4341515 10.8 % 13/10/2015
Breaking Stick Holdings, LLC Delaware 0 3300000 0 3300000 3300000 7.81 % 17/03/2015
James E. Flynn United States 0 8558475 0 8558475 8558475 19.985 % 17/03/2015
Deerfield Mgmt, L.P. Delaware 0 8558475 0 8558475 8558475 19.985 % 17/03/2015
Deerfield Special Situations Fund. L.P. Delaware 0 843559 0 843559 843559 2.17 % 17/03/2015
Deerfield Private Design Fund II, L.P. Delaware 0 5038315 0 5038315 5038315 11.93 % 17/03/2015
Deerfield Private Design International II, L.P. British Virgin Islands 0 5291975 0 5291975 5291975 12.53 % 17/03/2015
Deerfield Management Company, L.P. Delaware 0 8558475 0 8558475 8558475 19.985 % 17/03/2015
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 684626 0 684626 684626 1.76 % 17/03/2015
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 5153190 0 5153190 5153190 13.4 % 17/02/2015
Broadfin Capital, LLC Delaware 0 5153190 0 5153190 5153190 13.4 % 17/02/2015
Kevin Kotler United States of America 0 5153190 0 5153190 5153190 13.4 % 17/02/2015
Kevin Kotler United States of America 0 3767911 0 3767911 3767911 14.7 % 14/02/2014
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 3767911 0 3767911 3767911 14.7 % 14/02/2014
Broadfin Capital, LLC Delaware 0 3767911 0 3767911 3767911 14.7 % 14/02/2014
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 2981507 0 2981507 2981507 11.7 % 13/06/2013
Kevin Kotler United States of America 0 2981507 0 2981507 2981507 11.7 % 13/06/2013
Broadfin Capital, LLC Delaware 0 2981507 0 2981507 2981507 11.7 % 13/06/2013
JG Asset, LLC United States 0 0 0 0 0 0 % 14/02/2013
Visium Asset Management, LP United States 0 0 0 0 0 0 % 14/02/2013
Visium Balanced Master Fund, Ltd. Cayman Islands 0 0 0 0 0 0 % 14/02/2013
Jacob Gottlieb United States 0 0 0 0 0 0 % 14/02/2013
BVF Partners L.P. Delaware 0 216581 0 216581 216581 0 % 14/02/2013
Biotechnology Value Fund, L.P. Delaware 0 77484 0 77484 77484 0 % 14/02/2013
Biotechnology Value Fund II, L.P. Delaware 0 44613 0 44613 44613 0 % 14/02/2013
Investment 10, L.L.C. Illinois 0 29309 0 29309 29309 0 % 14/02/2013
BVF Inc. Delaware 0 216581 0 216581 216581 0 % 14/02/2013
Mark N. Lampert United States 0 216581 0 216581 216581 0 % 14/02/2013
BVF Investments, L.L.C. Delaware 0 65175 0 65175 65175 0 % 14/02/2013
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 2491261 0 2491261 2491261 9.98 % 14/02/2013
Broadfin Capital, LLC Delaware 0 2491261 0 2491261 2491261 9.98 % 14/02/2013
Kevin Kotler United States of America 0 2491261 0 2491261 2491261 9.98 % 14/02/2013
James E. Flynn United States 0 7633475 0 7633475 7633475 19.985 % 06/11/2012
Deerfield Special Situations Fund. L.P. Delaware 0 532712 0 532712 532712 2.12 % 06/11/2012
Deerfield Mgmt, L.P. Delaware 0 7633475 0 7633475 7633475 19.985 % 06/11/2012
Deerfield Private Design Fund II, L.P. Delaware 0 4732534 0 4732534 4732534 16.63 % 06/11/2012
Breaking Stick Holdings, LLC Delaware 0 3300000 0 3300000 3300000 11.6 % 06/11/2012
Deerfield Special Situations International Master Fund, L.P. British Virgin Islands 0 726655 0 726655 726655 2.89 % 06/11/2012
Deerfield Management Company, L.P. Delaware 0 7633475 0 7633475 7633475 19.985 % 06/11/2012
Deerfield Private Design International II, L.P. British Virgin Islands 0 4941574 0 4941574 4941574 17.37 % 06/11/2012
Broadfin Capital, LLC Delaware 0 1300000 0 1300000 1300000 5.2 % 28/09/2012
Broadfin Healthcare Master Fund, Ltd. Cayman Islands 0 1300000 0 1300000 1300000 5.2 % 28/09/2012
Kevin Kotler United States of America 0 1300000 0 1300000 1300000 5.2 % 28/09/2012
Visium Balanced Master Fund, Ltd Cayman Islands 1947042 0 1947042 0 1947042 7.9 % 10/02/2012
Jacob Gottlieb United States 1947042 0 1947042 0 1947042 7.9 % 10/02/2012
Visium Asset Management, LP United States 1947042 0 1947042 0 1947042 7.9 % 10/02/2012
JG Asset, LLC United States 1947042 0 1947042 0 1947042 7.9 % 10/02/2012
Biotechnology Value Fund, L.P. Delaware 0 427631 0 427631 427631 1.7 % 10/01/2012
Mark N. Lampert United States 0 1972251 0 1972251 1972251 8 % 10/01/2012
BVF Inc. Delaware 0 1972251 0 1972251 1972251 8 % 10/01/2012
BVF Partners L.P. Delaware 0 1972251 0 1972251 1972251 8 % 10/01/2012
Investment 10, L.L.C. Illinois 0 130362 0 130362 130362 0 % 10/01/2012
BVF Investments, L.L.C. Delaware 0 1137158 0 1137158 1137158 4.6 % 10/01/2012
Biotechnology Value Fund II, L.P. Delaware 0 277100 0 277100 277100 1.1 % 10/01/2012
O.S.S. Advisors LLC Delaware, USA 0 0 0 0 0 0 % 04/01/2012
Oscar S. Schafer United States 0 0 0 0 0 0 % 04/01/2012
Schafer Brothers LLC Delaware, USA 0 0 0 0 0 0 % 04/01/2012
O.S.S. Overseas Master Fund Ltd. Cayman Islands 0 0 0 0 0 0 % 04/01/2012
O.S.S. Overseas Fund Ltd. Cayman Islands 0 0 0 0 0 0 % 04/01/2012
Oscar S. Schafer & Partners II LP Delaware, USA 0 0 0 0 0 0 % 04/01/2012
Oscar S. Schafer & Partners I LP Delaware, USA 0 0 0 0 0 0 % 04/01/2012
O.S.S. Capital Management LP Delaware, USA 0 0 0 0 0 0 % 04/01/2012
Deerfield Management Company, L.P. Delaware 0 751823 0 751823 751823 3.05 % 31/08/2011
James E. Flynn United States 0 1232767 0 1232767 1232767 5 % 31/08/2011
Deerfield Special Situations Fund, L.P. Delaware 0 480944 0 480944 480944 1.95 % 31/08/2011
Deerfield Special Situations Fund International Limited British Virgin Islands 0 751823 0 751823 751823 3.05 % 31/08/2011
Deerfield Capital, L.P. Delaware 0 480944 0 480944 480944 1.95 % 31/08/2011
Oscar S. Schafer United States -50000 3072524 -50000 3072524 3122524 12.83 % 14/02/2011
Schafer Brothers LLC Delaware, USA 0 3072524 0 3072524 3072524 12.62 % 14/02/2011
O.S.S. Advisors LLC Delaware, USA 0 2175606 0 2175606 2175606 8.94 % 14/02/2011
O.S.S. Overseas Master Fund Ltd. Cayman Islands 0 889713 0 889713 889713 3.65 % 14/02/2011
O.S.S. Overseas Fund Ltd. Cayman Islands 0 889713 0 889713 889713 3.65 % 14/02/2011
O.S.S. Capital Management LP Delaware, USA 0 3072524 0 3072524 3072524 12.62 % 14/02/2011
Oscar S. Schafer & Partners I LP Delaware, USA 0 273021 0 273021 273021 1.12 % 14/02/2011
Oscar S. Schafer & Partners II LP Delaware, USA 0 1902585 0 1902585 1902585 7.82 % 14/02/2011
JG Asset, LLC United States 1747042 0 1747042 0 1747042 7.18 % 11/02/2011
Jacob Gottlieb United States 1747042 0 1747042 0 1747042 7.18 % 11/02/2011
Visium Balanced Master Fund, Ltd Cayman Islands 1747042 0 1747042 0 1747042 7.18 % 11/02/2011
Visium Asset Management, LP United States 1747042 0 1747042 0 1747042 7.18 % 11/02/2011
Mark N. Lampert United States 0 2848334 0 2848334 2848334 11.7 % 11/02/2011
Biotechnology Value Fund, L.P. Delaware 0 616879 0 616879 616879 2.5 % 11/02/2011
Biotechnology Value Fund II, L.P. Delaware 0 426935 0 426935 426935 1.8 % 11/02/2011
BVF Investments, L.L.C. Delaware 0 1630308 0 1630308 1630308 6.7 % 11/02/2011
Investment 10, L.L.C. Illinois 0 174212 0 174212 174212 0 % 11/02/2011
BVF Partners L.P. Delaware 0 2848334 0 2848334 2848334 11.7 % 11/02/2011
BVF Inc. Delaware 0 2848334 0 2848334 2848334 11.7 % 11/02/2011
Visium Balanced Master Fund, Ltd Cayman Islands 1850516 0 1850516 0 1850516 7.64 % 09/04/2010
Jacob Gottlieb United States 1850516 0 1850516 0 1850516 7.64 % 09/04/2010
JG Asset, LLC United States 1850516 0 1850516 0 1850516 7.64 % 09/04/2010
Visium Asset Management, LP United States 1850516 0 1850516 0 1850516 7.64 % 09/04/2010
O.S.S. Overseas Master Fund Ltd. Cayman Islands 0 1111348 0 1111348 1111348 4.59 % 31/03/2010
O.S.S. Advisors LLC Delaware, USA 0 2006571 0 2006571 2006571 8.28 % 31/03/2010
Schafer Brothers LLC Delaware, USA 0 3200000 0 3200000 3200000 13.21 % 31/03/2010
Oscar S. Schafer United States 50000 3200000 50000 3200000 3250000 13.42 % 31/03/2010
Oscar S. Schafer & Partners II LP Delaware, USA 0 1796744 0 1796744 1796744 7.42 % 31/03/2010
Oscar S. Schafer & Partners I LP Delaware, USA 0 209827 0 209827 209827 0.87 % 31/03/2010
O.S.S. Capital Management LP Delaware, USA 0 3200000 0 3200000 3200000 13.21 % 31/03/2010
BVF Inc. Delaware 0 3538774 0 3538774 3538774 14.6 % 10/02/2010
BVF Partners L.P. Delaware 0 3538774 0 3538774 3538774 14.6 % 10/02/2010
BVF Investments, L.L.C. Delaware 0 2011308 0 2011308 2011308 8.3 % 10/02/2010
Investment 10, L.L.C. Illinois 0 214212 0 214212 214212 0 % 10/02/2010
Biotechnology Value Fund II, L.P. Delaware 0 537935 0 537935 537935 2.2 % 10/02/2010
Biotechnology Value Fund, L.P. Delaware 0 775319 0 775319 775319 3.2 % 10/02/2010
Mark N. Lampert United States 0 3538774 0 3538774 3538774 14.6 % 10/02/2010
Europa International, Inc. British Virgin Islands 0 879241 0 879241 879241 3.5 % 29/01/2010
Knoll Capital Management, LP Delaware 0 879241 0 879241 879241 3.5 % 29/01/2010
Fred Knoll USA 0 879241 0 879241 879241 3.5 % 29/01/2010
BVF Investments, L.L.C. Delaware 0 962400 0 962400 962400 4 % 21/11/2007
Biotechnology Value Fund, L.P. Delaware 0 384157 0 384157 384157 1.6 % 21/11/2007
BVF Inc. Delaware 0 1755647 0 1755647 1755647 7.3 % 21/11/2007
Investments 10, L.L.C. Illinois 0 110720 0 110720 110720 0.5 % 21/11/2007
Biotechnology Value Fund II, L.P. Delaware 0 298370 0 298370 298370 1.2 % 21/11/2007
BVF Partners L.P. Delaware 0 1755647 0 1755647 1755647 7.3 % 21/11/2007
Knoll Capital Management, LP Delaware 0 1665374 0 1665374 1665374 7.8 % 20/04/2005
Fred Knoll USA 0 1665374 0 1665374 1665374 7.8 % 20/04/2005

Senat trading

Bureau Date de la transaction Date de réception Type Montant Commentaire

Senat Divulgation

Représentant Date de la transaction Date de divulgation Type Montant District