| (1)Names of reporting persons. BlackRock, Inc. |
Delaware |
0 |
0 |
5257004 |
0 |
5257004 |
5.5 % |
24/10/2024 |
| Polar Capital LLP |
United Kingdom |
6751782 |
0 |
6751782 |
0 |
6751782 |
7.51 % |
13/02/2024 |
| Polar Capital Holdings Plc |
United Kingdom |
6751782 |
0 |
6751782 |
0 |
6751782 |
7.51 % |
13/02/2024 |
| Janus Henderson Group plc |
Jersey, Channel Islands |
0 |
9443642 |
0 |
9443642 |
9443642 |
12.3 % |
10/08/2023 |
| Kevin Kotler |
United States of America |
3122100 |
0 |
3122100 |
0 |
3122100 |
5.1 % |
09/03/2023 |
| Kevin Kotler |
United States of America |
3440212 |
0 |
3440212 |
0 |
3440212 |
5.8 % |
06/06/2022 |
| Tontine Asset Associates, LLC |
Delaware |
0 |
2906665 |
0 |
2906665 |
2906665 |
4.92 % |
03/06/2022 |
| Jeffrey L. Gendell |
United States |
0 |
4174982 |
0 |
4174982 |
4174982 |
7.07 % |
03/06/2022 |
| Tontine Capital Overseas Master Fund II, L.P. |
Delaware |
0 |
2906665 |
0 |
2906665 |
2906665 |
4.92 % |
03/06/2022 |
| Polar Capital Holdings Plc |
United Kingdom |
0 |
2794673 |
0 |
0 |
2794673 |
4.8 % |
14/02/2022 |
| Polar Capital LLP |
United Kingdom |
0 |
2794673 |
0 |
0 |
2794673 |
4.8 % |
14/02/2022 |
| RTW Investments, LP |
Delaware |
0 |
5810140 |
0 |
0 |
5810140 |
9.99 % |
14/02/2022 |
| Roderick Wong |
United States |
0 |
5810140 |
0 |
0 |
5810140 |
9.99 % |
14/02/2022 |
| Vivo Capital Fund IX, L.P. |
Delaware |
535817 |
0 |
535817 |
0 |
535817 |
0.9 % |
11/02/2022 |
| LLC |
Delaware |
2401276 |
0 |
2401276 |
0 |
2401276 |
4.1 % |
11/02/2022 |
| Avoro Capital Advisors LLC |
Delaware |
1670000 |
0 |
1670000 |
0 |
1670000 |
2.9 % |
11/02/2022 |
| Behzad Aghazadeh |
United States |
1670000 |
0 |
1670000 |
0 |
1670000 |
2.9 % |
11/02/2022 |
| Brandes Worldwide Holdings, L.P. |
Delaware |
0 |
1672086 |
0 |
2599633 |
2599633 |
4.43 % |
08/02/2022 |
| Brandes Investment Partners, L.P. |
Delaware |
0 |
1672086 |
0 |
2599633 |
2599633 |
4.43 % |
08/02/2022 |
| Glenn Carlson |
USA |
0 |
1672086 |
0 |
2599633 |
2599633 |
4.43 % |
08/02/2022 |
| 73-1677697 |
Delaware |
0 |
1672086 |
0 |
2599633 |
2599633 |
4.43 % |
08/02/2022 |
| Polar Capital Holdings Plc |
United Kingdom |
0 |
3027705 |
0 |
0 |
3027705 |
5.2 % |
16/02/2021 |
| Polar Capital LLP |
United Kingdom |
0 |
3027705 |
0 |
0 |
3027705 |
5.2 % |
16/02/2021 |
| Roderick
Wong |
OR PLACE OF ORGANIZATION |
0 |
5387513 |
0 |
5387513 |
5387513 |
9.26 % |
12/02/2021 |
| RTW
Investments, LP |
OR PLACE OF ORGANIZATION |
0 |
5387513 |
0 |
5387513 |
5387513 |
9.26 % |
12/02/2021 |
| RTW
Master Fund, Ltd. |
OR PLACE OF ORGANIZATION |
0 |
3811140 |
0 |
3811140 |
3811140 |
6.55 % |
12/02/2021 |
| Avoro Capital Advisors LLC |
Delaware |
4365000 |
0 |
4365000 |
0 |
4365000 |
7.5 % |
12/02/2021 |
| Behzad Aghazadeh |
United States |
4365000 |
0 |
4365000 |
0 |
4365000 |
7.5 % |
12/02/2021 |
| Vivo
Capital Fund IX, L.P. |
OR PLACE OF ORGANIZATION |
643269 |
0 |
643269 |
0 |
643269 |
1.4 % |
04/03/2020 |
| Vivo
Opportunity, LLC |
OR PLACE OF ORGANIZATION |
2882824 |
0 |
2882824 |
0 |
2882824 |
6.2 % |
04/03/2020 |
| Roderick
Wong |
OR PLACE OF ORGANIZATION |
0 |
3401434 |
0 |
3401434 |
3401434 |
9.08 % |
14/02/2020 |
| RTW
Investments, LP |
OR PLACE OF ORGANIZATION |
0 |
3401434 |
0 |
3401434 |
3401434 |
9.08 % |
14/02/2020 |
| RTW
Master Fund, Ltd. |
OR PLACE OF ORGANIZATION |
0 |
2479370 |
0 |
2479370 |
2479370 |
6.62 % |
14/02/2020 |
| Broadfin Capital, LLC |
Delaware |
0 |
1029012 |
0 |
1029012 |
1029012 |
2.75 % |
13/02/2020 |
| Kevin Kotler |
Delaware |
0 |
1029012 |
0 |
1029012 |
1029012 |
2.75 % |
13/02/2020 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
1029012 |
0 |
1029012 |
1029012 |
2.75 % |
13/02/2020 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
| James E. Flynn |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
| Breaking Stick Holdings, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2020 |
| RTW
Master Fund, Ltd. |
OR PLACE OF ORGANIZATION |
0 |
2475390 |
0 |
2475390 |
2475390 |
6.61 % |
30/12/2019 |
| Roderick
Wong |
OR PLACE OF ORGANIZATION |
0 |
3396155 |
0 |
3396155 |
3396155 |
9.07 % |
30/12/2019 |
| RTW
Investments, LP |
OR PLACE OF ORGANIZATION |
0 |
3396155 |
0 |
3396155 |
3396155 |
9.07 % |
30/12/2019 |
| Advisors LLC |
Delaware |
0 |
14860 |
0 |
14860 |
14860 |
0.1 % |
14/02/2019 |
| Fund. L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2019 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
2722241 |
0 |
0 |
2722241 |
7.36 % |
12/02/2019 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
2722241 |
0 |
0 |
2722241 |
7.36 % |
12/02/2019 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
1734564 |
0 |
0 |
1734564 |
4.69 % |
12/02/2019 |
| Breaking Stick Holdings, LLC |
Delaware |
0 |
602762 |
0 |
0 |
602762 |
1.63 % |
12/02/2019 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
1590439 |
0 |
0 |
1590439 |
4.3 % |
12/02/2019 |
| James E. Flynn |
United States of America |
0 |
2722241 |
0 |
0 |
2722241 |
7.36 % |
12/02/2019 |
| 33-0836630 |
Delaware |
0 |
5990942 |
0 |
7119054 |
7119054 |
19.23 % |
10/01/2019 |
| Glenn Carlson |
USA |
0 |
5990942 |
0 |
7119054 |
7119054 |
19.23 % |
10/01/2019 |
| CO-GP, LLC. |
Delaware |
0 |
5990942 |
0 |
7119054 |
7119054 |
19.23 % |
10/01/2019 |
| Brandes Investment Partners, L.P. |
Delaware |
0 |
5990942 |
0 |
7119054 |
7119054 |
19.23 % |
10/01/2019 |
| Brandes Investment Partners, L.P. |
Delaware |
0 |
0 |
0 |
6177794 |
6177794 |
16.8 % |
05/09/2018 |
| Brandes Worldwide Holdings, L.P. |
Delaware |
0 |
0 |
0 |
6177794 |
6177794 |
16.8 % |
05/09/2018 |
| Glenn Carlson |
USA |
0 |
0 |
0 |
6177794 |
6177794 |
16.8 % |
05/09/2018 |
| CO-GP, LLC. |
California |
0 |
0 |
0 |
6177794 |
6177794 |
16.8 % |
05/09/2018 |
| Brandes Worldwide Holdings, L.P. |
Delaware |
0 |
0 |
0 |
4808493 |
4808493 |
12.67 % |
09/04/2018 |
| Brandes Investment Partners, L.P. |
Delaware |
0 |
0 |
0 |
4808493 |
4808493 |
12.67 % |
09/04/2018 |
| Glenn Carlson |
USA |
0 |
0 |
0 |
4808493 |
4808493 |
12.67 % |
09/04/2018 |
| CO-GP, LLC. |
California |
0 |
0 |
0 |
4808493 |
4808493 |
12.67 % |
09/04/2018 |
| (2) |
Delaware |
0 |
2391841 |
0 |
2391841 |
2391841 |
6 % |
14/02/2018 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
7255494 |
0 |
0 |
7255494 |
9.985 % |
14/02/2018 |
| Fund. L.P. |
Delaware |
0 |
1066299 |
0 |
0 |
1066299 |
2.68 % |
14/02/2018 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
4646365 |
0 |
0 |
4646365 |
9.985 % |
14/02/2018 |
| James E. Flynn |
United States of America |
0 |
7255494 |
0 |
0 |
7255494 |
9.985 % |
14/02/2018 |
| Breaking Stick Holdings, LLC |
Delaware |
0 |
3300000 |
0 |
0 |
3300000 |
7.66 % |
14/02/2018 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
7255494 |
0 |
0 |
7255494 |
9.985 % |
14/02/2018 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
4842830 |
0 |
0 |
4842830 |
9.985 % |
14/02/2018 |
| Kevin Kotler |
Delaware |
0 |
2591721 |
0 |
2591721 |
2591721 |
6.52 % |
13/02/2018 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
2591721 |
0 |
2591721 |
2591721 |
6.52 % |
13/02/2018 |
| Broadfin Capital, LLC |
Delaware |
0 |
2591721 |
0 |
2591721 |
2591721 |
6.52 % |
13/02/2018 |
| Brandes Investment Partners, L.P. |
Delaware |
0 |
3298109 |
0 |
3308250 |
3308250 |
7.99 % |
06/02/2018 |
| Brandes Investment Partners, Inc. |
Delaware |
0 |
3298109 |
0 |
3308250 |
3308250 |
7.99 % |
06/02/2018 |
| Charles H. Brandes |
Delaware |
0 |
3298109 |
0 |
3308250 |
3308250 |
7.99 % |
06/02/2018 |
| Brandes Worldwide Holdings, L.P. |
Delaware |
0 |
3298109 |
0 |
3308250 |
3308250 |
7.99 % |
06/02/2018 |
| 2 |
Delaware |
0 |
2241841 |
0 |
2241841 |
2241841 |
5.4 % |
09/11/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
7372809 |
0 |
0 |
7372809 |
9.985 % |
14/02/2017 |
| Breaking Stick Holdings, LLC |
Delaware |
0 |
3300000 |
0 |
0 |
3300000 |
7.41 % |
14/02/2017 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
7372809 |
0 |
0 |
7372809 |
9.985 % |
14/02/2017 |
| James E. Flynn |
United States |
0 |
7372809 |
0 |
0 |
7372809 |
9.985 % |
14/02/2017 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
4646365 |
0 |
0 |
4646365 |
9.985 % |
14/02/2017 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
4842830 |
0 |
0 |
4842830 |
9.985 % |
14/02/2017 |
| Deerfield Special Situations Fund. L.P. |
Delaware |
0 |
1183614 |
0 |
0 |
1183614 |
2.87 % |
14/02/2017 |
| Broadfin Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
06/01/2017 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
06/01/2017 |
| Kevin Kotler |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
06/01/2017 |
| Broadfin Capital, LLC |
Delaware |
0 |
4394464 |
0 |
4394464 |
4394464 |
10.7 % |
06/01/2017 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
4394464 |
0 |
4394464 |
4394464 |
10.7 % |
06/01/2017 |
| Kevin Kotler |
Delaware |
0 |
4394464 |
0 |
4394464 |
4394464 |
10.7 % |
06/01/2017 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
7372809 |
0 |
0 |
7372809 |
9.985 % |
22/03/2016 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
4842830 |
0 |
0 |
4842830 |
9.985 % |
22/03/2016 |
| Breaking Stick Holdings, LLC |
Delaware |
0 |
3300000 |
0 |
0 |
3300000 |
7.41 % |
22/03/2016 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
7372809 |
0 |
0 |
7372809 |
9.985 % |
22/03/2016 |
| Deerfield Special Situations Fund. L.P. |
Delaware |
0 |
1183614 |
0 |
0 |
1183614 |
2.87 % |
22/03/2016 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
4646365 |
0 |
0 |
4646365 |
9.985 % |
22/03/2016 |
| James E. Flynn |
United States of America |
0 |
7372809 |
0 |
0 |
7372809 |
9.985 % |
22/03/2016 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
4646365 |
0 |
0 |
4646365 |
9.985 % |
18/03/2016 |
| Deerfield Special Situations Fund. L.P. |
Delaware |
0 |
1183614 |
0 |
0 |
1183614 |
2.94 % |
18/03/2016 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
4842830 |
0 |
0 |
4842830 |
9.985 % |
18/03/2016 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
7372809 |
0 |
0 |
7372809 |
10.12 % |
18/03/2016 |
| James E. Flynn |
United States of America |
0 |
7372809 |
0 |
0 |
7372809 |
10.12 % |
18/03/2016 |
| Breaking Stick Holdings, LLC |
Delaware |
0 |
3300000 |
0 |
0 |
3300000 |
7.58 % |
18/03/2016 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
7372809 |
0 |
0 |
7372809 |
10.12 % |
18/03/2016 |
| Kevin Kotler |
Delaware |
0 |
4394464 |
0 |
4394464 |
4394464 |
10.9 % |
12/02/2016 |
| Broadfin Capital, LLC |
Delaware |
0 |
4394464 |
0 |
4394464 |
4394464 |
10.9 % |
12/02/2016 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
4394464 |
0 |
4394464 |
4394464 |
10.9 % |
12/02/2016 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
04/01/2016 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
7372809 |
0 |
0 |
7372809 |
9.985 % |
04/01/2016 |
| Breaking Stick Holdings, LLC |
Delaware |
0 |
3300000 |
0 |
0 |
3300000 |
7.43 % |
04/01/2016 |
| James E. Flynn |
United States of America |
0 |
7372809 |
0 |
0 |
7372809 |
9.985 % |
04/01/2016 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
4842830 |
0 |
0 |
4842830 |
9.985 % |
04/01/2016 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
4646365 |
0 |
0 |
4646365 |
9.985 % |
04/01/2016 |
| Deerfield Special Situations Fund. L.P. |
Delaware |
0 |
1183614 |
0 |
0 |
1183614 |
2.88 % |
04/01/2016 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
7372809 |
0 |
0 |
7372809 |
9.985 % |
04/01/2016 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
5291975 |
0 |
0 |
5291975 |
12.53 % |
17/03/2015 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
8558475 |
0 |
0 |
8558475 |
19.985 % |
17/03/2015 |
| Breaking Stick Holdings, LLC |
Delaware |
0 |
3300000 |
0 |
0 |
3300000 |
7.81 % |
17/03/2015 |
| James E. Flynn |
United States |
0 |
8558475 |
0 |
0 |
8558475 |
19.985 % |
17/03/2015 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
8558475 |
0 |
0 |
8558475 |
19.985 % |
17/03/2015 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
684626 |
0 |
0 |
684626 |
1.76 % |
17/03/2015 |
| Deerfield Special Situations Fund. L.P. |
Delaware |
0 |
843559 |
0 |
0 |
843559 |
2.17 % |
17/03/2015 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
5038315 |
0 |
0 |
5038315 |
11.93 % |
17/03/2015 |
| Broadfin Capital, LLC |
Delaware |
0 |
5153190 |
0 |
5153190 |
5153190 |
13.4 % |
17/02/2015 |
| Kevin Kotler |
Delaware |
0 |
5153190 |
0 |
5153190 |
5153190 |
13.4 % |
17/02/2015 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
5153190 |
0 |
5153190 |
5153190 |
13.4 % |
17/02/2015 |
| Broadfin Capital, LLC |
Delaware |
0 |
3767911 |
0 |
3767911 |
3767911 |
14.7 % |
14/02/2014 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
3767911 |
0 |
3767911 |
3767911 |
14.7 % |
14/02/2014 |
| Kevin Kotler |
Delaware |
0 |
3767911 |
0 |
3767911 |
3767911 |
14.7 % |
14/02/2014 |
| Kevin Kotler |
Delaware |
0 |
2981507 |
0 |
2981507 |
2981507 |
11.7 % |
13/06/2013 |
| Broadfin Capital, LLC |
Delaware |
0 |
2981507 |
0 |
2981507 |
2981507 |
11.7 % |
13/06/2013 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
2981507 |
0 |
2981507 |
2981507 |
11.7 % |
13/06/2013 |
| Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| LP |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| JG Asset, LLC |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| Jacob Gottlieb |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2013 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
65175 |
0 |
65175 |
77484 |
1 % |
14/02/2013 |
| Kevin Kotler |
Delaware |
0 |
2491261 |
0 |
2491261 |
2491261 |
9.98 % |
14/02/2013 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
2491261 |
0 |
2491261 |
2491261 |
9.98 % |
14/02/2013 |
| Broadfin Capital, LLC |
Delaware |
0 |
2491261 |
0 |
2491261 |
2491261 |
9.98 % |
14/02/2013 |
| Deerfield Mgmt, L.P. |
United States |
0 |
7633475 |
0 |
7633475 |
7633475 |
19.985 % |
06/11/2012 |
| Kevin Kotler |
Delaware |
0 |
1300000 |
0 |
1300000 |
1300000 |
5.2 % |
28/09/2012 |
| Broadfin Capital, LLC |
Delaware |
0 |
1300000 |
0 |
1300000 |
1300000 |
5.2 % |
28/09/2012 |
| Broadfin Healthcare Master Fund, Ltd. |
Delaware |
0 |
1300000 |
0 |
1300000 |
1300000 |
5.2 % |
28/09/2012 |
| Deerfield Special Situations International Master Fund, L.P. |
British Virgin Islands |
0 |
726655 |
0 |
10 |
726655 |
2.91 % |
07/09/2012 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
7633475 |
0 |
10 |
7633475 |
19.985 % |
07/09/2012 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
532712 |
0 |
10 |
532712 |
2.13 % |
07/09/2012 |
| James E. Flynn |
United States of America |
0 |
7633475 |
0 |
10 |
7633475 |
19.985 % |
07/09/2012 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
4941574 |
0 |
10 |
4941574 |
17.48 % |
07/09/2012 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
4732534 |
0 |
10 |
4732534 |
16.75 % |
07/09/2012 |
| Breaking Stick Holdings, LLC |
Delaware |
0 |
3300000 |
0 |
10 |
3300000 |
11.68 % |
07/09/2012 |
| Deerfield Mgmt, L.P. |
Delaware |
0 |
7633475 |
0 |
10 |
7633475 |
19.985 % |
07/09/2012 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
726655 |
0 |
10 |
726655 |
2.95 % |
15/03/2012 |
| Deerfield Private Design International II, L.P. |
British Virgin Islands |
0 |
1641574 |
0 |
10 |
1641574 |
6.66 % |
15/03/2012 |
| Deerfield Private Design Fund II, L.P. |
Delaware |
0 |
1432534 |
0 |
10 |
1432534 |
5.81 % |
15/03/2012 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
532712 |
0 |
10 |
532712 |
2.16 % |
15/03/2012 |
| Deerfield Capital, L.P. |
Delaware |
0 |
3606820 |
0 |
10 |
3606820 |
14.63 % |
15/03/2012 |
| James E. Flynn |
United States of America |
0 |
4333475 |
0 |
10 |
4333475 |
17.58 % |
15/03/2012 |
| Deerfield Special Situations Fund International Limited |
British Virgin Islands |
0 |
726655 |
0 |
10 |
726655 |
2.95 % |
15/03/2012 |
| JG Asset, LLC |
Cayman Islands |
1947042 |
0 |
1947042 |
0 |
1947042 |
7.9 % |
10/02/2012 |
| Jacob Gottlieb |
Cayman Islands |
1947042 |
0 |
1947042 |
0 |
1947042 |
7.9 % |
10/02/2012 |
| Ltd |
Cayman Islands |
1947042 |
0 |
1947042 |
0 |
1947042 |
7.9 % |
10/02/2012 |
| LP |
Cayman Islands |
1947042 |
0 |
1947042 |
0 |
1947042 |
7.9 % |
10/02/2012 |
| Investment 10, L.L.C. |
Delaware |
0 |
130362 |
0 |
0 |
130362 |
1 % |
10/01/2012 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
427631 |
0 |
0 |
427631 |
1.7 % |
10/01/2012 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
277100 |
0 |
0 |
277100 |
1.1 % |
10/01/2012 |
| Mark N. Lampert |
Delaware |
0 |
1972251 |
0 |
0 |
1972251 |
8 % |
10/01/2012 |
| BVF Partners L.P. |
Delaware |
0 |
1972251 |
0 |
0 |
1972251 |
8 % |
10/01/2012 |
| BVF Inc. |
Delaware |
0 |
1972251 |
0 |
0 |
1972251 |
8 % |
10/01/2012 |
| BVF Investments, L.L.C. |
Delaware |
0 |
1137158 |
0 |
0 |
1137158 |
4.6 % |
10/01/2012 |
| O.S.S. Overseas Master Fund Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
04/01/2012 |
| Oscar S. Schafer & Partners II LP |
Delaware, USA |
0 |
0 |
0 |
0 |
0 |
0 % |
04/01/2012 |
| O.S.S. Overseas Fund Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
04/01/2012 |
| O.S.S. Advisors LLC |
Delaware, USA |
0 |
0 |
0 |
0 |
0 |
0 % |
04/01/2012 |
| Oscar S. Schafer |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
04/01/2012 |
| Schafer Brothers LLC |
Delaware, USA |
0 |
0 |
0 |
0 |
0 |
0 % |
04/01/2012 |
| O.S.S. Capital Management LP |
Delaware, USA |
0 |
0 |
0 |
0 |
0 |
0 % |
04/01/2012 |
| Oscar S. Schafer & Partners I LP |
Delaware, USA |
0 |
0 |
0 |
0 |
0 |
0 % |
04/01/2012 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
726655 |
0 |
10 |
726655 |
2.95 % |
05/12/2011 |
| James E. Flynn |
United States of America |
0 |
1259367 |
0 |
10 |
1259367 |
5.11 % |
05/12/2011 |
| Deerfield Capital, L.P. |
Delaware |
0 |
532712 |
0 |
10 |
532712 |
2.16 % |
05/12/2011 |
| Deerfield Special Situations Fund International Limited |
British Virgin Islands |
0 |
726655 |
0 |
10 |
726655 |
2.95 % |
05/12/2011 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
532712 |
0 |
10 |
532712 |
2.16 % |
05/12/2011 |
| Deerfield Special Situations Fund, L.P. |
Delaware |
0 |
480944 |
0 |
0 |
480944 |
1.95 % |
31/08/2011 |
| Deerfield Management Company, L.P. |
Delaware |
0 |
751823 |
0 |
0 |
751823 |
3.05 % |
31/08/2011 |
| Deerfield Capital, L.P. |
Delaware |
0 |
480944 |
0 |
0 |
480944 |
1.95 % |
31/08/2011 |
| James E. Flynn |
United States |
0 |
1232767 |
0 |
0 |
1232767 |
5 % |
31/08/2011 |
| Deerfield Special Situations Fund International Limited |
British Virgin Islands |
0 |
751823 |
0 |
0 |
751823 |
3.05 % |
31/08/2011 |
| O.S.S. Capital Management LP |
Delaware, USA |
0 |
3072524 |
0 |
0 |
3072524 |
12.62 % |
14/02/2011 |
| Oscar S. Schafer & Partners I LP |
Delaware, USA |
0 |
273021 |
0 |
0 |
273021 |
1.12 % |
14/02/2011 |
| Oscar S. Schafer |
United States |
50000 |
3072524 |
50000 |
0 |
3122524 |
12.83 % |
14/02/2011 |
| O.S.S. Advisors LLC |
Delaware, USA |
0 |
2175606 |
0 |
0 |
2175606 |
8.94 % |
14/02/2011 |
| O.S.S. Overseas Master Fund Ltd. |
Cayman Islands |
0 |
889713 |
0 |
0 |
889713 |
3.65 % |
14/02/2011 |
| O.S.S. Overseas Fund Ltd. |
Cayman Islands |
0 |
889713 |
0 |
0 |
889713 |
3.65 % |
14/02/2011 |
| Schafer Brothers LLC |
Delaware, USA |
0 |
3072524 |
0 |
0 |
3072524 |
12.62 % |
14/02/2011 |
| Oscar S. Schafer & Partners II LP |
Delaware, USA |
0 |
1902585 |
0 |
0 |
1902585 |
7.82 % |
14/02/2011 |
| Jacob Gottlieb |
Cayman Islands |
1747042 |
0 |
1747042 |
0 |
1747042 |
7.18 % |
11/02/2011 |
| Visium Asset Management, LP |
Cayman Islands |
1747042 |
0 |
1747042 |
0 |
1747042 |
7.18 % |
11/02/2011 |
| Visium Balanced Master Fund, Ltd |
Cayman Islands |
1747042 |
0 |
1747042 |
0 |
1747042 |
7.18 % |
11/02/2011 |
| JG Asset, LLC |
Cayman Islands |
1747042 |
0 |
1747042 |
0 |
1747042 |
7.18 % |
11/02/2011 |
| Investment 10, L.L.C. |
Delaware |
0 |
174212 |
0 |
0 |
174212 |
1 % |
11/02/2011 |
| BVF Inc. |
Delaware |
0 |
2848334 |
0 |
0 |
2848334 |
11.7 % |
11/02/2011 |
| BVF Partners L.P. |
Delaware |
0 |
2848334 |
0 |
0 |
2848334 |
11.7 % |
11/02/2011 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
616879 |
0 |
0 |
616879 |
2.5 % |
11/02/2011 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
426935 |
0 |
0 |
426935 |
1.8 % |
11/02/2011 |
| BVF Investments, L.L.C. |
Delaware |
0 |
1630308 |
0 |
0 |
1630308 |
6.7 % |
11/02/2011 |
| Mark N. Lampert |
Delaware |
0 |
2848334 |
0 |
0 |
2848334 |
11.7 % |
11/02/2011 |
| Jacob Gottlieb |
Cayman Islands |
1850516 |
0 |
1850516 |
0 |
1850516 |
7.64 % |
09/04/2010 |
| JG Asset, LLC |
Cayman Islands |
1850516 |
0 |
1850516 |
0 |
1850516 |
7.64 % |
09/04/2010 |
| Visium Asset Management, LP |
Cayman Islands |
1850516 |
0 |
1850516 |
0 |
1850516 |
7.64 % |
09/04/2010 |
| Visium Balanced Master Fund, Ltd |
Cayman Islands |
1850516 |
0 |
1850516 |
0 |
1850516 |
7.64 % |
09/04/2010 |
| O.S.S. Overseas Master Fund Ltd. |
Delaware, USA |
0 |
1111348 |
0 |
1111348 |
1111348 |
4.59 % |
31/03/2010 |
| Oscar S. Schafer |
Delaware, USA |
0 |
3200000 |
0 |
0 |
3250000 |
13.42 % |
31/03/2010 |
| O.S.S. Advisors LLC |
Delaware, USA |
0 |
0 |
0 |
2006571 |
2006571 |
8.28 % |
31/03/2010 |
| Schafer Brothers LLC |
Delaware, USA |
0 |
0 |
0 |
3200000 |
3200000 |
13.21 % |
31/03/2010 |
| O.S.S. Capital Management LP |
Delaware, USA |
0 |
3200000 |
0 |
3200000 |
3200000 |
13.21 % |
31/03/2010 |
| Oscar S. Schafer & Partners I LP |
Delaware, USA |
0 |
0 |
209827 |
209827 |
209827 |
0.87 % |
31/03/2010 |
| Oscar S. Schafer & Partners II LP |
Delaware, USA |
0 |
1796744 |
0 |
1796744 |
1796744 |
7.42 % |
31/03/2010 |
| Inc. |
United States |
0 |
3538774 |
0 |
0 |
3538774 |
14.6 % |
10/02/2010 |
| Partners L.P. |
United States |
0 |
3538774 |
0 |
0 |
3538774 |
14.6 % |
10/02/2010 |
| 10, L.L.C. |
United States |
0 |
214212 |
0 |
0 |
214212 |
1 % |
10/02/2010 |
| Investments, L.L.C. |
United States |
0 |
2011308 |
0 |
0 |
2011308 |
8.3 % |
10/02/2010 |
| Value Fund, L.P. |
United States |
0 |
775319 |
0 |
0 |
775319 |
3.2 % |
10/02/2010 |
| Value Fund II, L.P. |
United States |
0 |
537935 |
0 |
0 |
537935 |
2.2 % |
10/02/2010 |
| N. Lampert |
United States |
0 |
3538774 |
0 |
0 |
3538774 |
14.6 % |
10/02/2010 |
| Europa
International, Inc. |
OR PLACE OF ORGANIZATION |
0 |
0 |
0 |
879241 |
879241 |
3.5 % |
29/01/2010 |
| Knoll
Capital Management, LP |
OR PLACE OF ORGANIZATION |
0 |
0 |
0 |
879241 |
879241 |
3.5 % |
29/01/2010 |
| Fred
Knoll |
OR PLACE OF ORGANIZATION |
0 |
0 |
0 |
879241 |
879241 |
3.5 % |
29/01/2010 |
| Silver Point Capital, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2009 |
| Robert J. O’Shea |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2009 |
| Edward A. Mulé |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
17/02/2009 |
| Europa International, Inc. |
British Virgin Islands |
0 |
1222416 |
0 |
0 |
1222416 |
5.07 % |
17/02/2009 |
| Knoll Capital Management, LP |
Delaware |
0 |
1265749 |
0 |
0 |
1265749 |
5.25 % |
17/02/2009 |
| Fred Knoll |
USA |
0 |
1265749 |
0 |
0 |
1265749 |
5.25 % |
17/02/2009 |
| Third Point Offshore Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2008 |
| Third Point LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2008 |
| Daniel S. Loeb |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
13/02/2008 |
| Fred Knoll |
USA |
0 |
2230463 |
0 |
0 |
2230463 |
9.28 % |
11/02/2008 |
| Knoll Capital Management, LP |
Delaware |
0 |
2230463 |
0 |
0 |
2230463 |
9.28 % |
11/02/2008 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
384157 |
384157 |
1.6 % |
21/11/2007 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
1755647 |
1755647 |
7.3 % |
21/11/2007 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
1755647 |
1755647 |
7.3 % |
21/11/2007 |
| Investments 10, L.L.C. |
Delaware |
0 |
0 |
0 |
110720 |
110720 |
0.5 % |
21/11/2007 |
| BVF Investments, L.L.C. |
Delaware |
0 |
0 |
0 |
962400 |
962400 |
4 % |
21/11/2007 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
298370 |
298370 |
1.2 % |
21/11/2007 |
| Daniel S. Loeb |
United States |
0 |
2200000 |
0 |
2200000 |
2200000 |
9.2 % |
16/07/2007 |
| Third Point LLC |
Delaware |
0 |
2200000 |
0 |
2200000 |
2200000 |
9.2 % |
16/07/2007 |
| Third Point Offshore Fund, Ltd. |
Cayman Islands |
0 |
1413500 |
0 |
1413500 |
1413500 |
5.9 % |
16/07/2007 |
| Knoll Capital Management, LP |
Delaware |
0 |
2111438 |
0 |
2111438 |
2111438 |
8.51 % |
14/02/2007 |
| Fred Knoll |
USA |
0 |
2111438 |
0 |
2111438 |
2111438 |
8.51 % |
14/02/2007 |
| Glenn J. Krevlin |
United States |
0 |
0 |
0 |
0 |
1207567 |
5.1 % |
16/10/2006 |
| 13-4153005 |
Delaware |
0 |
0 |
0 |
0 |
1207567 |
5.1 % |
16/10/2006 |
| Knoll Capital Management, LP |
Delaware |
0 |
2012684 |
0 |
2012684 |
2012684 |
8.51 % |
09/02/2006 |
| Fred Knoll |
USA |
0 |
2012684 |
0 |
2012684 |
2012684 |
8.51 % |
09/02/2006 |
| 20-1998394 |
Delaware |
0 |
0 |
0 |
0 |
191205 |
0.809 % |
13/01/2006 |
| 13-4146739 |
Delaware |
0 |
0 |
0 |
0 |
871413 |
3.686 % |
13/01/2006 |
| 98-0375906 |
Cayman Islands |
0 |
0 |
0 |
0 |
291241 |
1.232 % |
13/01/2006 |
| 02-0625266 |
Delaware |
0 |
0 |
0 |
0 |
291241 |
1.232 % |
13/01/2006 |
| 98-0426132 |
Cayman Islands |
0 |
0 |
0 |
0 |
291241 |
1.232 % |
13/01/2006 |
| 98-0426124 |
Cayman Islands |
0 |
0 |
0 |
0 |
291241 |
1.232 % |
13/01/2006 |
| (. |
United States |
0 |
0 |
0 |
0 |
1162654 |
4.918 % |
13/01/2006 |
| 13-4153005 |
Delaware |
0 |
0 |
0 |
0 |
1162654 |
4.918 % |
13/01/2006 |
| 20-1998485 |
Delaware |
0 |
0 |
0 |
0 |
191205 |
0.809 % |
13/01/2006 |
| 13-4149785 |
Delaware |
0 |
0 |
0 |
0 |
680208 |
2.877 % |
13/01/2006 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
776652 |
0 |
10 |
776652 |
3.62 % |
21/04/2005 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
847770 |
0 |
10 |
847770 |
3.95 % |
21/04/2005 |
| BVF Investments, L.L.C. |
Delaware |
0 |
836600 |
0 |
10 |
836600 |
3.9 % |
21/04/2005 |
| BVF Inc. |
Delaware |
0 |
2591142 |
0 |
10 |
2591142 |
12.08 % |
21/04/2005 |
| Investment 10, L.L.C. |
Illinois |
0 |
130120 |
0 |
10 |
130120 |
0.61 % |
21/04/2005 |
| BVF Partners L.P. |
Delaware |
0 |
2591142 |
0 |
10 |
2591142 |
12.08 % |
21/04/2005 |
| Fred Knoll |
USA |
0 |
1665374 |
0 |
1665374 |
1665374 |
7.8 % |
20/04/2005 |
| Knoll Capital Management, LP |
Delaware |
0 |
1665374 |
0 |
1665374 |
1665374 |
7.8 % |
20/04/2005 |
| Fred Knoll |
USA |
0 |
1106717 |
0 |
1106717 |
1106717 |
6.8 % |
08/04/2004 |
| Knoll Capital Management, LP |
Delaware |
0 |
1106717 |
0 |
1106717 |
1106717 |
6.8 % |
08/04/2004 |