BioDelivery Sciences International, Inc. BDSI
Trading inactive
| Déclarant | Citoyenneté ou lieu d'organisation | Pouvoir de vote unique | Pouvoir de vote partagé | Pouvoir de disposition unique | Pouvoir de disposition partagé | Montant en propriété effective | Pourcentage détenu | Date d'achat |
|---|---|---|---|---|---|---|---|---|
| Magnetar Capital Partners LP | Delaware | 0 | 6695999 | 0 | 6695999 | 6695999 | 6.77 % | 24/02/2022 |
| Alec N. Litowitz | 0 | 6695999 | 0 | 6695999 | 6695999 | 6.77 % | 24/02/2022 | |
| Supernova Management LLC | Delaware | 0 | 6695999 | 0 | 6695999 | 6695999 | 6.77 % | 24/02/2022 |
| Magnetar Financial LLC | Delaware | 0 | 6695999 | 0 | 6695999 | 6695999 | 6.77 % | 24/02/2022 |
| Magnetar Capital Partners LP | 0 | 6695999 | 0 | 6695999 | 6695999 | 6.77 % | 24/02/2022 | |
| Alec N. Litowitz | States of America | 0 | 6695999 | 0 | 6695999 | 6695999 | 6.77 % | 24/02/2022 |
| Magnetar Financial LLC | 0 | 6695999 | 0 | 6695999 | 6695999 | 6.77 % | 24/02/2022 | |
| Supernova Management LLC | 0 | 6695999 | 0 | 6695999 | 6695999 | 6.77 % | 24/02/2022 | |
| Asset Management Exchange Master ICAV | Ireland | 5018146 | 0 | 5018146 | 0 | 5018146 | 5.08 % | 24/02/2022 |
| Asset Management Exchange Master ICAV | Ireland | 5018146 | 0 | 5018146 | 0 | 5018146 | 5.08 % | 24/02/2022 |
| Wilmot B. Harkey | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2022 |
| Nantahala Capital Management, LLC | MA | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2022 |
| Daniel Mack | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2022 |
| Deerfield Partners, L.P. | Delaware | 0 | 29204 | 0 | 0 | 29204 | 0.03 % | 11/02/2022 |
| Company, L.P. | Delaware | 0 | 29204 | 0 | 0 | 29204 | 0.03 % | 11/02/2022 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 29204 | 0 | 0 | 29204 | 0.03 % | 11/02/2022 |
| James E. Flynn | United States | 0 | 29204 | 0 | 0 | 29204 | 0.03 % | 11/02/2022 |
| (1) BlackRock, Inc. | Delaware | 7051483 | 0 | 7305512 | 0 | 7305512 | 7.4 % | 02/02/2022 |
| Daniel Mack | USA | 0 | 5123671 | 0 | 0 | 5123671 | 5.1 % | 16/02/2021 |
| Wilmot B. Harkey | USA | 0 | 5123671 | 0 | 0 | 5123671 | 5.1 % | 16/02/2021 |
| Nantahala Capital Management, LLC | MA | 0 | 5123671 | 0 | 0 | 5123671 | 5.1 % | 16/02/2021 |
| Nantahala Capital Management, LLC | MA | 0 | 5123671 | 0 | 0 | 5123671 | 5.1 % | 16/02/2021 |
| Wilmot B. Harkey | MA | 0 | 5123671 | 0 | 0 | 5123671 | 5.1 % | 16/02/2021 |
| Daniel Mack | MA | 0 | 5123671 | 0 | 0 | 5123671 | 5.1 % | 16/02/2021 |
| James E. Flynn | United States | 0 | 9530000 | 0 | 0 | 9530000 | 9.43 % | 12/02/2021 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 9530000 | 0 | 0 | 9530000 | 9.43 % | 12/02/2021 |
| Company, L.P. | Delaware | 0 | 9530000 | 0 | 0 | 9530000 | 9.43 % | 12/02/2021 |
| James E. Flynn | Delaware | 0 | 9530000 | 0 | 0 | 9530000 | 9.43 % | 12/02/2021 |
| Deerfield Partners, L.P. | Delaware | 0 | 9530000 | 0 | 0 | 9530000 | 9.43 % | 12/02/2021 |
| Company, L.P. | Delaware | 0 | 9530000 | 0 | 0 | 9530000 | 9.43 % | 12/02/2021 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 9530000 | 0 | 0 | 9530000 | 9.43 % | 12/02/2021 |
| Deerfield Partners, L.P. | Delaware | 0 | 9530000 | 0 | 0 | 9530000 | 9.43 % | 12/02/2021 |
| (1) BlackRock, Inc. | Delaware | 8032519 | 0 | 8214641 | 0 | 8214641 | 8.1 % | 28/01/2021 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 6545500 | 0 | 0 | 6545500 | 6.79 % | 06/04/2020 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 6545500 | 0 | 0 | 6545500 | 6.79 % | 06/04/2020 |
| Deerfield Management Company, L.P. | Delaware | 0 | 6545500 | 0 | 0 | 6545500 | 6.79 % | 06/04/2020 |
| Deerfield Partners, L.P. | Delaware | 0 | 6545500 | 0 | 0 | 6545500 | 6.79 % | 06/04/2020 |
| James E. Flynn | United States | 0 | 6545500 | 0 | 0 | 6545500 | 6.79 % | 06/04/2020 |
| Deerfield Management Company, L.P. | Delaware | 0 | 6545500 | 0 | 0 | 6545500 | 6.79 % | 06/04/2020 |
| James E. Flynn | Delaware | 0 | 6545500 | 0 | 0 | 6545500 | 6.79 % | 06/04/2020 |
| Deerfield Partners, L.P. | Delaware | 0 | 6545500 | 0 | 0 | 6545500 | 6.79 % | 06/04/2020 |
| Daniel Mack | USA | 0 | 4846167 | 0 | 0 | 4846167 | 5.4 % | 14/02/2020 |
| Wilmot B. Harkey | USA | 0 | 4846167 | 0 | 0 | 4846167 | 5.4 % | 14/02/2020 |
| Daniel Mack | MA | 0 | 4846167 | 0 | 0 | 4846167 | 5.4 % | 14/02/2020 |
| Wilmot B. Harkey | MA | 0 | 4846167 | 0 | 0 | 4846167 | 5.4 % | 14/02/2020 |
| Nantahala Capital Management, LLC | MA | 0 | 4846167 | 0 | 0 | 4846167 | 5.4 % | 14/02/2020 |
| Nantahala Capital Management, LLC | MA | 0 | 4846167 | 0 | 0 | 4846167 | 5.4 % | 14/02/2020 |
| Advisor LLC) | Delaware | 3000000 | 0 | 3000000 | 0 | 3000000 | 3.34 % | 14/02/2020 |
| Behzad Aghazadeh | United States | 3000000 | 0 | 3000000 | 0 | 3000000 | 3.34 % | 14/02/2020 |
| Jon M. Plexico | U.S.A. | 0 | 0 | 0 | 0 | 0 | 11 % | 13/02/2020 |
| Stonepine Capital Management, LLC | U.S.A. | 0 | 0 | 0 | 0 | 0 | 11 % | 13/02/2020 |
| Stonepine Capital, L.P. | U.S.A. | 0 | 0 | 0 | 0 | 0 | 11 % | 13/02/2020 |
| Timothy P. Lynch | U.S.A. | 0 | 0 | 0 | 0 | 0 | 11 % | 13/02/2020 |
| (1) BlackRock, Inc. | Delaware | 7123056 | 0 | 7304342 | 0 | 7304342 | 8.1 % | 07/02/2020 |
| Steven Boyd | Cayman Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2019 |
| Armistice Capital Master Fund Ltd. | Cayman Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2019 |
| Armistice Capital, LLC | Cayman Islands | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2019 |
| Behzad Aghazadeh | United States | 8614588 | 0 | 8614588 | 0 | 8614588 | 9.98 % | 14/02/2019 |
| venBio Select Advisor LLC | Delaware | 8614588 | 0 | 8614588 | 0 | 8614588 | 9.98 % | 14/02/2019 |
| Timothy P. Lynch | U.S.A. | 3981867 | 0 | 3981867 | 0 | 3981867 | 11 % | 12/02/2019 |
| Jon M. Plexico | U.S.A. | 3981867 | 0 | 3981867 | 0 | 3981867 | 11 % | 12/02/2019 |
| Stonepine Capital Management, LLC | California | 3981867 | 0 | 3981867 | 0 | 3981867 | 11 % | 12/02/2019 |
| Stonepine Capital, L.P. | California | 3981867 | 0 | 3981867 | 0 | 3981867 | 11 % | 12/02/2019 |
| Stonepine Capital, L.P. | Delaware | 3981867 | 0 | 3981867 | 0 | 3981867 | 11 % | 12/02/2019 |
| Timothy P. Lynch | California | 3981867 | 0 | 3981867 | 0 | 3981867 | 11 % | 12/02/2019 |
| Jon M. Plexico | California | 3981867 | 0 | 3981867 | 0 | 3981867 | 11 % | 12/02/2019 |
| Stonepine Capital Management, LLC | California | 3981867 | 0 | 3981867 | 0 | 3981867 | 11 % | 12/02/2019 |
| Armistice Capital Master Fund Ltd. | Delaware | 0 | 3692000 | 0 | 3692000 | 3692000 | 6.2 % | 16/08/2018 |
| Armistice Capital Master Fund Ltd. | Delaware | 0 | 3692000 | 0 | 3692000 | 3692000 | 6.2 % | 16/08/2018 |
| Armistice Capital, LLC | Delaware | 0 | 3692000 | 0 | 3692000 | 3692000 | 6.2 % | 16/08/2018 |
| Armistice Capital, LLC | Delaware | 0 | 3692000 | 0 | 3692000 | 3692000 | 6.2 % | 16/08/2018 |
| Steven Boyd | Delaware | 0 | 3692000 | 0 | 3692000 | 3692000 | 6.2 % | 16/08/2018 |
| Steven Boyd | Delaware | 0 | 3692000 | 0 | 3692000 | 3692000 | 6.2 % | 16/08/2018 |
| Jon M. Plexico | U.S.A. | 3645491 | 0 | 3645491 | 0 | 3645491 | 11 % | 13/02/2018 |
| Timothy P. Lynch | U.S.A. | 3645491 | 0 | 3645491 | 0 | 3645491 | 11 % | 13/02/2018 |
| Stonepine Capital Management, LLC | California | 3645491 | 0 | 3645491 | 0 | 3645491 | 11 % | 13/02/2018 |
| Stonepine Capital, L.P. | Delaware | 3645491 | 0 | 3645491 | 0 | 3645491 | 11 % | 13/02/2018 |
| Broadfin Healthcare Master Fund, Ltd. | Delaware | 0 | 4634119 | 0 | 4634119 | 4634119 | 8.29 % | 13/02/2018 |
| Broadfin Capital, LLC | Delaware | 0 | 4634119 | 0 | 4634119 | 4634119 | 8.29 % | 13/02/2018 |
| Kevin Kotler | Delaware | 0 | 4634119 | 0 | 4634119 | 4634119 | 8.29 % | 13/02/2018 |
| Abigail P. Johnson | Delaware | 0 | 0 | 250 | 0 | 250 | 0 % | 14/02/2017 |
| FMR LLC | Delaware | 250 | 0 | 250 | 0 | 250 | 0 % | 14/02/2017 |
| Armistice Capital Master Fund, Ltd. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Steven Boyd | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Armistice Capital, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2017 |
| Kevin Kotler | Cayman Islands | 0 | 5398794 | 0 | 5398794 | 5398794 | 9.98 % | 13/02/2017 |
| Broadfin Healthcare Master Fund, Ltd. | Cayman Islands | 0 | 5398794 | 0 | 5398794 | 5398794 | 9.98 % | 13/02/2017 |
| Broadfin Capital, LLC | Cayman Islands | 0 | 5398794 | 0 | 5398794 | 5398794 | 9.98 % | 13/02/2017 |
| 2) | Minnesota | 0 | 3143317 | 0 | 3143737 | 3143737 | 5.81 % | 10/02/2017 |
| Timothy P. Lynch | California | 3228493 | 0 | 3228493 | 0 | 3228493 | 6 % | 13/01/2017 |
| Timothy P. Lynch | U.S.A. | 3228493 | 0 | 3228493 | 0 | 3228493 | 6 % | 13/01/2017 |
| Stonepine Capital Management, LLC | California | 3228493 | 0 | 3228493 | 0 | 3228493 | 6 % | 13/01/2017 |
| Stonepine Capital, L.P. | California | 3228493 | 0 | 3228493 | 0 | 3228493 | 6 % | 13/01/2017 |
| Jon M. Plexico | California | 3228493 | 0 | 3228493 | 0 | 3228493 | 6 % | 13/01/2017 |
| Jon M. Plexico | U.S.A. | 3228493 | 0 | 3228493 | 0 | 3228493 | 6 % | 13/01/2017 |
| Stonepine Capital, L.P. | Delaware | 3228493 | 0 | 3228493 | 0 | 3228493 | 6 % | 13/01/2017 |
| Stonepine Capital Management, LLC | California | 3228493 | 0 | 3228493 | 0 | 3228493 | 6 % | 13/01/2017 |
| (1) BlackRock, Inc. | Delaware | 1101871 | 0 | 1116801 | 0 | 1116801 | 2.1 % | 08/07/2016 |
| Voting Shares Irrevocable Trust | Citizenship or place of Organization | 2420700 | 0 | 2420700 | 0 | 2420700 | 4.53 % | 10/05/2016 |
| John F. Donahue | Citizenship or place of Organization | 0 | 2420700 | 0 | 2420700 | 2420700 | 4.53 % | 10/05/2016 |
| Federated Investors, Inc. | Citizenship or place of Organization | 2420700 | 0 | 2420700 | 0 | 2420700 | 4.53 % | 10/05/2016 |
| Rhodora J. Donahue | Citizenship or place of Organization | 0 | 2420700 | 0 | 2420700 | 2420700 | 4.53 % | 10/05/2016 |
| J. Christopher Donahue | Citizenship or place of Organization | 0 | 2420700 | 0 | 2420700 | 2420700 | 4.53 % | 10/05/2016 |
| STATE STREET CORPORATION | BOSTON, MASSACHUSETTS | 0 | 682462 | 0 | 682462 | 682462 | 1.3 % | 22/02/2016 |
| Point72 Asset Management, L.P. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| EverPoint Asset Management, LLC | Delaware | 0 | 435585 | 0 | 0 | 435585 | 0.8 % | 16/02/2016 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| Cubist Systematic Strategies, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 16/02/2016 |
| Steven A. Cohen | United States | 0 | 435585 | 0 | 0 | 435585 | 0.8 % | 16/02/2016 |
| Kevin Kotler | Delaware | 0 | 5188794 | 0 | 5188794 | 5188794 | 9.85 % | 12/02/2016 |
| Broadfin Healthcare Master Fund, Ltd. | Delaware | 0 | 5188794 | 0 | 5188794 | 5188794 | 9.85 % | 12/02/2016 |
| Broadfin Capital, LLC | Delaware | 0 | 5188794 | 0 | 5188794 | 5188794 | 9.85 % | 12/02/2016 |
| J. Christopher Donahue | Citizenship or place of Organization | 0 | 2960554 | 0 | 2960554 | 2960554 | 5.62 % | 11/02/2016 |
| Federated Investors, Inc. | Citizenship or place of Organization | 2960554 | 0 | 2960554 | 0 | 2960554 | 5.62 % | 11/02/2016 |
| Voting Shares Irrevocable Trust | Citizenship or place of Organization | 2960554 | 0 | 2960554 | 0 | 2960554 | 5.62 % | 11/02/2016 |
| Rhodora J. Donahue | Citizenship or place of Organization | 0 | 2960554 | 0 | 2960554 | 2960554 | 5.62 % | 11/02/2016 |
| John F. Donahue | Citizenship or place of Organization | 0 | 2960554 | 0 | 2960554 | 2960554 | 5.62 % | 11/02/2016 |
| 98-0557567 | Bermuda | 799 | 0 | 799 | 0 | 799 | 0 % | 29/01/2016 |
| (1) BlackRock, Inc. | Delaware | 2765591 | 0 | 2867492 | 0 | 2867492 | 5.4 % | 28/01/2016 |
| Armistice Capital, LLC | Delaware | 0 | 3132000 | 0 | 3132000 | 3132000 | 5.9 % | 21/01/2016 |
| Armistice Capital, LLC | Delaware | 0 | 3132000 | 0 | 3132000 | 3132000 | 5.9 % | 21/01/2016 |
| Armistice Capital Master Fund, Ltd. | Delaware | 0 | 3132000 | 0 | 3132000 | 3132000 | 5.9 % | 21/01/2016 |
| Steven Boyd | Delaware | 0 | 3132000 | 0 | 3132000 | 3132000 | 5.9 % | 21/01/2016 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 16900 | 0 | 0 | 16900 | 4 % | 01/07/2015 |
| Point72 Capital Advisors, Inc. | Delaware | 0 | 16900 | 0 | 0 | 16900 | 4 % | 01/07/2015 |
| Point72 Asset Management, L.P. | Delaware | 0 | 16900 | 0 | 0 | 16900 | 4 % | 01/07/2015 |
| Point72 Asset Management, L.P. | Delaware | 0 | 16900 | 0 | 0 | 16900 | 4 % | 01/07/2015 |
| Steven A. Cohen | United States | 0 | 2886362 | 0 | 0 | 2886362 | 5.5 % | 01/07/2015 |
| Steven A. Cohen | Delaware | 0 | 2886362 | 0 | 0 | 2886362 | 5.5 % | 01/07/2015 |
| EverPoint Asset Management, LLC | Delaware | 0 | 2850000 | 0 | 0 | 2850000 | 5.4 % | 01/07/2015 |
| EverPoint Asset Management, LLC | Delaware | 0 | 2850000 | 0 | 0 | 2850000 | 5.4 % | 01/07/2015 |
| Cubist Systematic Strategies, LLC | Delaware | 0 | 19462 | 0 | 0 | 19462 | 4 % | 01/07/2015 |
| Cubist Systematic Strategies, LLC | Delaware | 0 | 19462 | 0 | 0 | 19462 | 4 % | 01/07/2015 |
| Broadfin Capital, LLC | Delaware | 0 | 3894060 | 0 | 3894060 | 3894060 | 7.33 % | 20/05/2015 |
| Broadfin Healthcare Master Fund, Ltd. | Delaware | 0 | 3894060 | 0 | 3894060 | 3894060 | 7.33 % | 20/05/2015 |
| Kevin Kotler | Delaware | 0 | 3894060 | 0 | 3894060 | 3894060 | 7.33 % | 20/05/2015 |
| Broadfin Capital, LLC | Delaware | 0 | 3894060 | 0 | 3894060 | 3894060 | 7.33 % | 20/05/2015 |
| Broadfin Healthcare Master Fund, Ltd. | Delaware | 0 | 3894060 | 0 | 3894060 | 3894060 | 7.33 % | 20/05/2015 |
| Kevin Kotler | Delaware | 0 | 3894060 | 0 | 3894060 | 3894060 | 7.33 % | 20/05/2015 |
| (1) BlackRock, Inc. | Delaware | 2450678 | 0 | 2540241 | 0 | 2540241 | 4.9 % | 08/05/2015 |
| Federated Investors, Inc. | Citizenship or place of Organization | 2451694 | 0 | 2451694 | 0 | 2451694 | 4.69 % | 07/05/2015 |
| Voting Shares Irrevocable Trust | Citizenship or place of Organization | 2451694 | 0 | 2451694 | 0 | 2451694 | 4.69 % | 07/05/2015 |
| John F. Donahue | Citizenship or place of Organization | 0 | 2451694 | 0 | 2451694 | 2451694 | 4.69 % | 07/05/2015 |
| J. Christopher Donahue | Citizenship or place of Organization | 0 | 2451694 | 0 | 2451694 | 2451694 | 4.69 % | 07/05/2015 |
| Rhodora J. Donahue | Citizenship or place of Organization | 0 | 2451694 | 0 | 2451694 | 2451694 | 4.69 % | 07/05/2015 |
| Julian C. Baker | United States | 2349021 | 0 | 2349021 | 0 | 2349021 | 4.4 % | 17/02/2015 |
| 13-4093645 | Delaware | 2349021 | 0 | 2349021 | 0 | 2349021 | 4.4 % | 17/02/2015 |
| 46-3147749 | Delaware | 2349021 | 0 | 2349021 | 0 | 2349021 | 4.4 % | 17/02/2015 |
| Felix J. Baker | United States | 2349021 | 0 | 2349021 | 0 | 2349021 | 4.4 % | 17/02/2015 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 800000 | 0 | 0 | 800000 | 1.56 % | 17/02/2015 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 800000 | 0 | 0 | 800000 | 1.56 % | 17/02/2015 |
| Adage Capital Partners, L.P. | Delaware | 0 | 800000 | 0 | 0 | 800000 | 1.56 % | 17/02/2015 |
| Robert Atchinson | United States | 0 | 800000 | 0 | 0 | 800000 | 1.56 % | 17/02/2015 |
| Phillip Gross | United States | 0 | 800000 | 0 | 0 | 800000 | 1.56 % | 17/02/2015 |
| Broadfin Capital, LLC | Delaware | 0 | 2396399 | 0 | 2396399 | 2396399 | 4.7 % | 17/02/2015 |
| Broadfin Healthcare Master Fund, Ltd. | Delaware | 0 | 2396399 | 0 | 2396399 | 2396399 | 4.7 % | 17/02/2015 |
| Kevin Kotler | Delaware | 0 | 2396399 | 0 | 2396399 | 2396399 | 4.7 % | 17/02/2015 |
| Deerfield Management Company, L.P. | Delaware | 0 | 464083 | 0 | 0 | 464083 | 0.9 % | 17/02/2015 |
| James E. Flynn | United States | 0 | 464083 | 0 | 0 | 464083 | 0.9 % | 17/02/2015 |
| Deerfield International Master Fund, L.P. | Delaware | 0 | 258030 | 0 | 0 | 258030 | 0.5 % | 17/02/2015 |
| Deerfield Partners, L.P. | Delaware | 0 | 206053 | 0 | 0 | 206053 | 0.4 % | 17/02/2015 |
| Deerfield Management Company, L.P. | Delaware | 0 | 464083 | 0 | 0 | 464083 | 0.9 % | 17/02/2015 |
| Deerfield International Master Fund, L.P. | British Virgin Islands | 0 | 258030 | 0 | 0 | 258030 | 0.5 % | 17/02/2015 |
| James E. Flynn | Delaware | 0 | 464083 | 0 | 0 | 464083 | 0.9 % | 17/02/2015 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 464083 | 0 | 0 | 464083 | 0.9 % | 17/02/2015 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 464083 | 0 | 0 | 464083 | 0.9 % | 17/02/2015 |
| Deerfield Partners, L.P. | Delaware | 0 | 206053 | 0 | 0 | 206053 | 0.4 % | 17/02/2015 |
| FMR LLC | Delaware | 700 | 0 | 2105499 | 0 | 2105499 | 4.105 % | 13/02/2015 |
| Abigail P. Johnson | United States of America | 0 | 0 | 2105499 | 0 | 2105499 | 4.105 % | 13/02/2015 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 2105499 | 0 | 2105499 | 4.105 % | 13/02/2015 |
| STATE STREET CORPORATION | BOSTON MASSACHUSETTS | 0 | 2865420 | 0 | 2865420 | 2865420 | 5.6 % | 11/02/2015 |
| Voting Shares Irrevocable Trust | Citizenship or place of Organization | 4377696 | 0 | 4377696 | 0 | 4377696 | 8.54 % | 11/02/2015 |
| J. Christopher Donahue | Citizenship or place of Organization | 0 | 4377696 | 0 | 4377696 | 4377696 | 8.54 % | 11/02/2015 |
| Rhodora J. Donahue | Citizenship or place of Organization | 0 | 4377696 | 0 | 4377696 | 4377696 | 8.54 % | 11/02/2015 |
| John F. Donahue | Citizenship or place of Organization | 0 | 4377696 | 0 | 4377696 | 4377696 | 8.54 % | 11/02/2015 |
| Federated Investors, Inc. | Citizenship or place of Organization | 4377696 | 0 | 4377696 | 0 | 4377696 | 8.54 % | 11/02/2015 |
| (1) BlackRock, Inc. | Delaware | 2516241 | 0 | 2605344 | 0 | 2605344 | 5.1 % | 06/02/2015 |
| (1) BlackRock, Inc. | Delaware | 2255986 | 0 | 2314067 | 0 | 2314067 | 4.9 % | 07/03/2014 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 2331025 | 0 | 0 | 2331025 | 6.02 % | 14/02/2014 |
| Deerfield Management Company, L.P. | Delaware | 0 | 2331025 | 0 | 0 | 2331025 | 6.02 % | 14/02/2014 |
| James E. Flynn | United States | 0 | 2331025 | 0 | 0 | 2331025 | 6.02 % | 14/02/2014 |
| Deerfield Special Situations International Master Fund, L.P. | British Virgin Islands | 0 | 1067815 | 0 | 0 | 1067815 | 2.78 % | 14/02/2014 |
| Deerfield Special Situations Fund, L.P. | Delaware | 0 | 1263210 | 0 | 0 | 1263210 | 3.29 % | 14/02/2014 |
| 46-3147749 | Delaware | 2985005 | 0 | 2985005 | 0 | 2985005 | 7.4 % | 14/02/2014 |
| Felix J. Baker | United States | 2985005 | 0 | 2985005 | 0 | 2985005 | 7.4 % | 14/02/2014 |
| Julian C. Baker | United States | 2985005 | 0 | 2985005 | 0 | 2985005 | 7.4 % | 14/02/2014 |
| 13-4093645 | Delaware | 2985005 | 0 | 2985005 | 0 | 2985005 | 7.4 % | 14/02/2014 |
| Broadfin Healthcare Master Fund, Ltd. | Delaware | 0 | 2222054 | 0 | 2222054 | 2222054 | 5.8 % | 13/02/2014 |
| Broadfin Capital, LLC | Delaware | 0 | 2222054 | 0 | 2222054 | 2222054 | 5.8 % | 13/02/2014 |
| Kevin Kotler | Delaware | 0 | 2222054 | 0 | 2222054 | 2222054 | 5.8 % | 13/02/2014 |
| (1) BlackRock, Inc. | Delaware | 2081030 | 0 | 2124949 | 0 | 2124949 | 5.6 % | 28/01/2014 |
| Edward C. Johnson 3d | Delaware | 0 | 0 | 2916731 | 0 | 2916731 | 7.671 % | 10/01/2014 |
| FMR LLC | Delaware | 1095 | 0 | 2916731 | 0 | 2916731 | 7.671 % | 10/01/2014 |
| Kevin Kotler | Delaware | 0 | 2017000 | 0 | 2017000 | 2017000 | 6.6 % | 11/03/2013 |
| Broadfin Healthcare Master Fund, Ltd. | Delaware | 0 | 2017000 | 0 | 2017000 | 2017000 | 6.6 % | 11/03/2013 |
| Broadfin Capital, LLC | Delaware | 0 | 2017000 | 0 | 2017000 | 2017000 | 6.6 % | 11/03/2013 |
| Broadfin Healthcare Master Fund, Ltd. | Delaware | 0 | 2017000 | 0 | 2017000 | 2017000 | 6.6 % | 11/03/2013 |
| Kevin Kotler | Delaware | 0 | 2017000 | 0 | 2017000 | 2017000 | 6.6 % | 11/03/2013 |
| Broadfin Capital, LLC | Delaware | 0 | 2017000 | 0 | 2017000 | 2017000 | 6.6 % | 11/03/2013 |
| Edward C. Johnson 3d | United States of America | 0 | 0 | 5205495 | 0 | 5205495 | 13.888 % | 14/02/2013 |
| FMR LLC | Delaware | 113448 | 0 | 5205495 | 0 | 5205495 | 13.888 % | 14/02/2013 |
| 2 | UNITED STATES AMERICA | 3175490 | 0 | 3175490 | 0 | 3175490 | 3 % | 11/02/2013 |
| Julian C. Baker | United States | 3164426 | 0 | 3164426 | 0 | 3164426 | 9.98 % | 01/02/2013 |
| 13-4093645 | Delaware | 3164426 | 0 | 3164426 | 0 | 3164426 | 9.98 % | 01/02/2013 |
| Felix J. Baker | United States | 3164426 | 0 | 3164426 | 0 | 3164426 | 9.98 % | 01/02/2013 |
| (1) BlackRock, Inc. | Delaware | 1946697 | 0 | 1946697 | 0 | 1946697 | 5.19 % | 30/01/2013 |
| Deerfield Special Situations International Master Fund, L.P. | British Virgin Islands | 0 | 1158062 | 0 | 0 | 1158062 | 3.06 % | 10/12/2012 |
| Deerfield Special Situations Fund, L.P. | Delaware | 0 | 986553 | 0 | 0 | 986553 | 2.61 % | 10/12/2012 |
| James E. Flynn | United States | 0 | 2144615 | 0 | 0 | 2144615 | 5.64 % | 10/12/2012 |
| Deerfield Management Company, L.P. | Delaware | 0 | 2144615 | 0 | 0 | 2144615 | 5.64 % | 10/12/2012 |
| Deerfield Mgmt, L.P. | Delaware | 0 | 2144615 | 0 | 0 | 2144615 | 5.64 % | 10/12/2012 |
| Adage Capital Partners, L.P. | Delaware | 0 | 2300000 | 0 | 0 | 2300000 | 6.13 % | 06/12/2012 |
| Robert Atchinson | United States | 0 | 2300000 | 0 | 0 | 2300000 | 6.13 % | 06/12/2012 |
| Phillip Gross | United States | 0 | 2300000 | 0 | 0 | 2300000 | 6.13 % | 06/12/2012 |
| Adage Capital Partners GP, L.L.C. | Delaware | 0 | 2300000 | 0 | 0 | 2300000 | 6.13 % | 06/12/2012 |
| Adage Capital Advisors, L.L.C. | Delaware | 0 | 2300000 | 0 | 0 | 2300000 | 6.13 % | 06/12/2012 |
| Adage Capital Partners, L.P. | Delaware | 0 | 2300000 | 0 | 2300000 | 2300000 | 6.13 % | 06/12/2012 |
| Marsh & McLennan Companies, Inc. | Delaware | 2175476 | 2175476 | 0 | 0 % | 04/12/2012 | ||
| FMR LLC | Delaware | 0 | 0 | 3023500 | 0 | 3023500 | 10.199 % | 11/06/2012 |
| Edward C. Johnson 3d | Delaware | 0 | 0 | 3023500 | 0 | 3023500 | 10.199 % | 11/06/2012 |
| FMR LLC | Delaware | 0 | 0 | 3023500 | 0 | 3023500 | 10.199 % | 11/06/2012 |
| Edward C. Johnson 3d | Delaware | 0 | 0 | 3023500 | 0 | 3023500 | 10.199 % | 11/06/2012 |
| Capital, LLC | Delaware | 1943000 | 0 | 0 | 1943000 | 1943000 | 6.57 % | 17/04/2012 |
| Capital, LLC | Delaware | 1943000 | 0 | 0 | 1943000 | 1943000 | 6.57 % | 17/04/2012 |
| Felix J. Baker | United States | 0 | 2595044 | 0 | 2595044 | 2595044 | 8.8 % | 14/02/2012 |
| Julian C. Baker | United States | 0 | 2595044 | 0 | 2595044 | 2595044 | 8.8 % | 14/02/2012 |
| Dr. Jeffrey R. Jay, M.D. | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2012 |
| Mr. David Kroin | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2012 |
| Great Point Partners, LLC | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2012 |
| Great Point Partners, LLC | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2012 |
| Mr. David Kroin | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2012 |
| Dr. Jeffrey R. Jay, M.D. | USA | 0 | 0 | 0 | 0 | 0 | 0 % | 14/02/2012 |
| BARCLAYS GLOBAL INVESTORS, NA. | USA | 0 | 19231001 | 0 | 19231001 | 349221 | 2.4 % | 21/03/2011 |
| Deutsche Bank AG* | USA | 0 | 19231001 | 0 | 19231001 | 15072004 | 5.48 % | 21/03/2011 |
| Felix J. Baker | United States | 0 | 2403848 | 0 | 2403848 | 2403848 | 8.3 % | 21/03/2011 |
| Julian C. Baker | United States | 0 | 2403848 | 0 | 2403848 | 2403848 | 8.3 % | 21/03/2011 |
| Eugene Grin | United States | 0 | 833871 | 0 | 833871 | 833871 | 3.96 % | 16/02/2010 |
| PSource Structured Debt Limited | Guernsey | 0 | 833871 | 0 | 833871 | 833871 | 3.96 % | 16/02/2010 |
| David Grin | United States and Israel | 0 | 833871 | 0 | 833871 | 833871 | 3.96 % | 16/02/2010 |
| Laurus Capital Management, LLC | Delaware | 0 | 833871 | 0 | 833871 | 833871 | 3.96 % | 16/02/2010 |
| HOPKINS CAPITAL GROUP II LLC | MISSOURI | 400000 | 0 | 400000 | 0 | 400000 | 20.5 % | 12/03/2009 |
| FRANCIS E. O’DONNELL, JR. | UNITED STATES OF AMERICA | 182500 | 0 | 182500 | 0 | 182500 | 22.3 % | 12/03/2009 |
| Laurus Capital Management, LLC | Delaware | 0 | 1914437 | 0 | 1914437 | 1914437 | 9.99 % | 11/02/2009 |
| Eugene Grin | United States | 0 | 1914437 | 0 | 1914437 | 1914437 | 9.99 % | 11/02/2009 |
| David Grin | Israel | 0 | 1914437 | 0 | 1914437 | 1914437 | 9.99 % | 11/02/2009 |
| PSource Structured Debt Limited | Guernsey | 0 | 1914437 | 0 | 1914437 | 1914437 | 9.99 % | 11/02/2009 |
| Ridgeback Capital Management LLC 42-1684320 | USA | 0 | 341442 | 0 | 0 | 341442 | 1.8 % | 14/02/2008 |
| 00-0000000 | USA | 0 | 341442 | 0 | 0 | 341442 | 1.8 % | 14/02/2008 |
| 00-0000000 | USA | 0 | 341442 | 0 | 0 | 341442 | 1.8 % | 14/02/2008 |
| Wayne Holman | USA | 0 | 341442 | 0 | 0 | 341442 | 1.8 % | 14/02/2008 |
| CDC Operations LLC | State of Delaware | 0 | 4505120 | 0 | 10 | 904000 | 27.4 % | 16/03/2007 |
| Jan Leschly | America | 0 | 4505120 | 0 | 10 | 904000 | 27.4 % | 16/03/2007 |
| Argeris Karabelas | America | 0 | 4505120 | 0 | 10 | 904000 | 27.4 % | 16/03/2007 |
| CDC IV, LLC | State of Delaware | 0 | 4505120 | 0 | 10 | 904000 | 27.4 % | 16/03/2007 |
| David R. Ramsay | America | 0 | 4505120 | 0 | 10 | 904000 | 27.4 % | 16/03/2007 |
| Ridgeback Capital Management LLC 42-1684320 | Delaware | 0 | 700000 | 0 | 0 | 700000 | 5 % | 05/03/2007 |
| Wayne Holman | USA | 0 | 700000 | 0 | 0 | 700000 | 5 % | 05/03/2007 |
| 00-0000000 | Cayman Islands | 0 | 700000 | 0 | 0 | 700000 | 5 % | 05/03/2007 |
| Eugene Grin | United States | 0 | 1392420 | 0 | 1392420 | 1392420 | 9.99 % | 14/02/2007 |
| Laurus Capital Management, LLC | Delaware | 0 | 1392420 | 0 | 1392420 | 1392420 | 9.99 % | 14/02/2007 |
| David Grin | Israel | 0 | 1392420 | 0 | 1392420 | 1392420 | 9.99 % | 14/02/2007 |
| Laurus Master Fund, Ltd. | Cayman Islands | 0 | 1392420 | 0 | 1392420 | 1392420 | 9.99 % | 14/02/2007 |
| Eugene Grin | United States | 0 | 1392420 | 0 | 1392420 | 1392420 | 9.99 % | 08/01/2007 |
| David Grin | Israel | 0 | 1392420 | 0 | 1392420 | 1392420 | 9.99 % | 08/01/2007 |
| Laurus Capital Management, LLC | Delaware | 0 | 1392420 | 0 | 1392420 | 1392420 | 9.99 % | 08/01/2007 |
| Laurus Master Fund, Ltd. | Cayman Islands | 0 | 1392420 | 0 | 1392420 | 1392420 | 9.99 % | 08/01/2007 |
| Andrew L. Finn | States | 0 | 0 | 0 | 0 | 797985 | 6.36 % | 14/02/2006 |
| Mark A. Sirgo | States | 0 | 0 | 0 | 0 | 838285 | 6.65 % | 14/02/2006 |
| Pharmaceutical Product Development, Inc. | North Carolina | 0 | 0 | 0 | 0 | 1380000 | 18 % | 11/02/2004 |
| Stonestreet, L.P. | Canada | 336600 | 0 | 336600 | 0 | 336600 | 4.8 % | 28/10/2003 |
| Stonestreet, L.P. | Canada | 400000 | 0 | 400000 | 0 | 400000 | 5.7 % | 28/10/2003 |