| Anand Parekh |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
| Alyeska Investment Group, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
| Alyeska Fund GP, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
| Granahan Investment Management LLC |
State of Massachusetts |
0 |
0 |
0 |
0 |
0 |
0 % |
14/11/2024 |
| The Vanguard Group |
Pennsylvania |
0 |
87543 |
10330825 |
143182 |
10474007 |
5.4 % |
14/11/2024 |
| The Vanguard Group |
Pennsylvania |
0 |
87543 |
10330825 |
143182 |
10474007 |
5.4 % |
13/11/2024 |
| BlackRock, Inc. |
Delaware |
15230542 |
0 |
15443767 |
0 |
15443767 |
8 % |
08/11/2024 |
| The Vanguard Group |
Pennsylvania |
0 |
87543 |
10330825 |
143182 |
10474007 |
5.4 % |
04/11/2024 |
| The Vanguard Group |
Pennsylvania |
0 |
87543 |
10330825 |
143182 |
10474007 |
5.4 % |
04/11/2024 |
| BlackRock, Inc. |
Delaware |
0 |
0 |
15443767 |
0 |
15443767 |
8 % |
22/10/2024 |
| PFM Health Sciences GP, LLC |
Delaware |
0 |
2042651 |
0 |
2042651 |
2042651 |
1.9 % |
14/02/2024 |
| Partner Asset Management, LLC |
Delaware |
0 |
2042651 |
0 |
2042651 |
2042651 |
1.9 % |
14/02/2024 |
| Brian D. Grossman |
U.S. Citizen |
0 |
2042651 |
0 |
2042651 |
2042651 |
1.9 % |
14/02/2024 |
| PFM Health Sciences, LP |
Delaware |
0 |
2042651 |
0 |
2042651 |
2042651 |
1.9 % |
14/02/2024 |
| Kevin Tang |
united states |
|
1700000 |
0 |
1700000 |
1700000 |
0.9 % |
14/02/2024 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
|
1700000 |
0 |
1700000 |
1700000 |
0.9 % |
14/02/2024 |
| Kevin Tang |
united states |
|
1700000 |
0 |
1700000 |
1700000 |
0.9 % |
14/02/2024 |
| Tang Capital Management, LLC |
DELAWARE |
|
1700000 |
0 |
1700000 |
1700000 |
0.9 % |
14/02/2024 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
|
1700000 |
0 |
1700000 |
1700000 |
0.9 % |
14/02/2024 |
| Tang Capital Management, LLC |
DELAWARE |
|
1700000 |
0 |
1700000 |
1700000 |
0.9 % |
14/02/2024 |
| Alyeska Fund GP, LLC |
Delaware |
0 |
6912502 |
0 |
6912502 |
0 |
6.32 % |
14/02/2024 |
| Alyeska Investment Group, L.P. |
Delaware |
0 |
6912502 |
0 |
6912502 |
0 |
6.32 % |
14/02/2024 |
| Anand Parekh |
United States of America |
0 |
6912502 |
0 |
6912502 |
0 |
6.32 % |
14/02/2024 |
| Granahan Investment Management LLC |
State of Massachusetts |
6741868 |
0 |
8077697 |
0 |
8077697 |
7.38 % |
14/02/2024 |
| Granahan Investment Management LLC |
State of Massachusetts |
6741868 |
0 |
8077697 |
0 |
8077697 |
7.38 % |
14/02/2024 |
| SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
11895595 |
0 |
11909995 |
11909995 |
6.26 % |
25/01/2024 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
13756321 |
0 |
13865719 |
13865719 |
7.28 % |
25/01/2024 |
| BlackRock, Inc. |
Delaware |
8832224 |
0 |
8983001 |
0 |
8983001 |
4.7 % |
08/01/2024 |
| PFM Health Sciences, LP |
Delaware |
0 |
6021843 |
0 |
6021843 |
6021843 |
5.7 % |
21/04/2023 |
| PFM Health Sciences, LP |
Delaware |
0 |
6021843 |
0 |
6021843 |
6021843 |
5.7 % |
21/04/2023 |
| PFM Health Sciences GP, LLC |
Delaware |
0 |
6021843 |
0 |
6021843 |
6021843 |
5.7 % |
21/04/2023 |
| Partner Asset Management, LLC |
Delaware |
0 |
6021843 |
0 |
6021843 |
6021843 |
5.7 % |
21/04/2023 |
| Brian D. Grossman |
U.S. Citizen |
0 |
6021843 |
0 |
6021843 |
6021843 |
5.7 % |
21/04/2023 |
| Brian D. Grossman |
U.S. Citizen |
0 |
6021843 |
0 |
6021843 |
6021843 |
5.7 % |
21/04/2023 |
| Partner Asset Management, LLC |
Delaware |
0 |
6021843 |
0 |
6021843 |
6021843 |
5.7 % |
21/04/2023 |
| PFM Health Sciences GP, LLC |
Delaware |
0 |
6021843 |
0 |
6021843 |
6021843 |
5.7 % |
21/04/2023 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
11579272 |
0 |
11683114 |
11683114 |
11.03 % |
10/03/2023 |
| SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
9995131 |
0 |
10009531 |
10009531 |
9.45 % |
10/03/2023 |
| The Vanguard Group |
Pennsylvania |
0 |
61259 |
4138335 |
127985 |
4266320 |
5.15 % |
09/02/2023 |
| First Trust Advisors L.P. The Charger Corporation |
Illinois, U.S.A. |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2023 |
| First Trust Advisors L.P. The Charger Corporation |
Illinois, U.S.A. |
0 |
0 |
0 |
0 |
0 |
0 % |
03/02/2023 |
| BlackRock, Inc. |
Delaware |
7110236 |
0 |
7367181 |
0 |
7367181 |
8.9 % |
25/01/2023 |
| Millennium Group Management LLC |
|
|
|
|
|
973085 |
1.2 % |
12/01/2023 |
| Millennium Management LLC |
|
|
|
|
|
973085 |
1.2 % |
12/01/2023 |
| Israel A. Englander |
|
|
|
|
|
973085 |
1.2 % |
12/01/2023 |
| Millennium Management LLC |
|
|
|
|
|
973085 |
1.2 % |
12/01/2023 |
| Millennium Group Management LLC |
|
|
|
|
|
973085 |
1.2 % |
12/01/2023 |
| Israel A. Englander |
|
|
|
|
|
973085 |
1.2 % |
12/01/2023 |
| SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
11132385 |
0 |
11146785 |
11146785 |
14.45 % |
11/10/2022 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
12643238 |
0 |
12720480 |
12720480 |
16.49 % |
11/10/2022 |
| Wellington Group Holdings LLP |
Delaware |
0 |
235790 |
0 |
244061 |
244061 |
0.32 % |
09/09/2022 |
| Wellington Management Group LLP |
Massachusetts |
0 |
235790 |
0 |
244061 |
244061 |
0.32 % |
09/09/2022 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
235790 |
0 |
244061 |
244061 |
0.32 % |
09/09/2022 |
| Millennium Management LLC |
|
|
|
|
|
3873900 |
5.4 % |
01/08/2022 |
| Millennium Group Management LLC |
|
|
|
|
|
3873900 |
5.4 % |
01/08/2022 |
| Millennium Management LLC |
|
|
|
|
|
3873900 |
5.4 % |
01/08/2022 |
| Millennium Group Management LLC |
|
|
|
|
|
3873900 |
5.4 % |
01/08/2022 |
| Israel A. Englander |
|
|
|
|
|
3873900 |
5.4 % |
01/08/2022 |
| Israel A. Englander |
|
|
|
|
|
3873900 |
5.4 % |
01/08/2022 |
| The Vanguard Group |
Pennsylvania |
0 |
36345 |
3445499 |
61410 |
3506909 |
4.91 % |
11/07/2022 |
| The Vanguard Group |
Pennsylvania |
0 |
36345 |
3445499 |
61410 |
3506909 |
4.91 % |
11/07/2022 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
1746465 |
0 |
1825101 |
1825101 |
2.55 % |
11/07/2022 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
|
3721056 |
0 |
3721056 |
3721056 |
5.2 % |
03/06/2022 |
| Kevin Tang |
united states |
|
3721056 |
0 |
3721056 |
3721056 |
5.2 % |
03/06/2022 |
| Tang Capital Management, LLC |
DELAWARE |
|
3721056 |
0 |
3721056 |
3721056 |
5.2 % |
03/06/2022 |
| TANG CAPITAL PARTNERS, LP |
DELAWARE |
|
3721056 |
0 |
3721056 |
3721056 |
5.2 % |
03/06/2022 |
| Tang Capital Management, LLC |
DELAWARE |
|
3721056 |
0 |
3721056 |
3721056 |
5.2 % |
03/06/2022 |
| Kevin Tang |
united states |
|
3721056 |
0 |
3721056 |
3721056 |
5.2 % |
03/06/2022 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
13013070 |
0 |
13151891 |
13151891 |
18.41 % |
11/04/2022 |
| SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
11868400 |
0 |
11882800 |
11882800 |
16.63 % |
11/04/2022 |
| The Vanguard Group |
Pennsylvania |
0 |
53838 |
7120948 |
112642 |
7233590 |
10.32 % |
09/02/2022 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
6140000 |
0 |
6140000 |
6140000 |
8.76 % |
04/02/2022 |
| Wellington Management Company LLP |
Delaware |
0 |
6140000 |
0 |
6140000 |
6140000 |
8.76 % |
04/02/2022 |
| Wellington Management Group LLP |
Massachusetts |
0 |
6140000 |
0 |
6140000 |
6140000 |
8.76 % |
04/02/2022 |
| Wellington Group Holdings LLP |
Delaware |
0 |
6140000 |
0 |
6140000 |
6140000 |
8.76 % |
04/02/2022 |
| BlackRock, Inc. |
Delaware |
5747306 |
0 |
5912002 |
0 |
5912002 |
8.4 % |
02/02/2022 |
| First Trust Advisors L.P. The Charger Corporation |
Illinois, U.S.A. |
0 |
0 |
0 |
0 |
5204825 |
7.42 % |
26/01/2022 |
| First Trust Advisors L.P. The Charger Corporation |
Illinois, U.S.A. |
0 |
0 |
0 |
0 |
5204825 |
7.42 % |
26/01/2022 |
| SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
6376057 |
0 |
6390457 |
6390457 |
9.12 % |
10/01/2022 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
7478489 |
0 |
7617310 |
7617310 |
10.87 % |
10/01/2022 |
| The Vanguard Group |
Pennsylvania |
0 |
46707 |
6694305 |
103214 |
6797519 |
10.12 % |
12/04/2021 |
| The Vanguard Group |
Pennsylvania |
0 |
46707 |
6694305 |
103214 |
6797519 |
10.12 % |
12/04/2021 |
| Capital Research Global Investors |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/03/2021 |
| Capital Research Global Investors |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
10/03/2021 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
6850320 |
0 |
6915454 |
6915454 |
10.3 % |
10/03/2021 |
| Wellington Management Company LLP |
Delaware |
0 |
6850320 |
0 |
6850320 |
6850320 |
10.2 % |
10/03/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
6850320 |
0 |
6915454 |
6915454 |
10.3 % |
10/03/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
6850320 |
0 |
6915454 |
6915454 |
10.3 % |
10/03/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
6850320 |
0 |
6915454 |
6915454 |
10.3 % |
10/03/2021 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
6850320 |
0 |
6915454 |
6915454 |
10.3 % |
10/03/2021 |
| Wellington Management Company LLP |
Delaware |
0 |
6850320 |
0 |
6850320 |
6850320 |
10.2 % |
10/03/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
6850320 |
0 |
6915454 |
6915454 |
10.3 % |
10/03/2021 |
| Capital Research Global Investors |
Delaware |
8128284 |
0 |
8128284 |
0 |
8128284 |
12.2 % |
16/02/2021 |
| Capital Research Global Investors |
Delaware |
8128284 |
0 |
8128284 |
0 |
8128284 |
12.2 % |
16/02/2021 |
| Capital World Investors |
Delaware |
3127163 |
0 |
3127163 |
0 |
3127163 |
4.7 % |
16/02/2021 |
| Capital World Investors |
Delaware |
3127163 |
0 |
3127163 |
0 |
3127163 |
4.7 % |
16/02/2021 |
| Sands Capital Management, LLC |
Delaware, United States |
|
0 |
3163651 |
0 |
3163651 |
4.77 % |
16/02/2021 |
| The Vanguard Group |
Pennsylvania |
0 |
47357 |
6364196 |
99036 |
6463232 |
9.74 % |
10/02/2021 |
| BlackRock, Inc. |
Delaware |
3622760 |
0 |
3861648 |
0 |
3861648 |
5.8 % |
28/01/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
5349165 |
0 |
5349165 |
5349165 |
8.06 % |
11/01/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
5349165 |
0 |
5349165 |
5349165 |
8.06 % |
11/01/2021 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
5349165 |
0 |
5349165 |
5349165 |
8.06 % |
11/01/2021 |
| Wellington Management Company LLP |
Delaware |
0 |
5349165 |
0 |
5349165 |
5349165 |
8.06 % |
11/01/2021 |
| Wellington Management Group LLP |
Massachusetts |
0 |
5349165 |
0 |
5349165 |
5349165 |
8.06 % |
11/01/2021 |
| Wellington Group Holdings LLP |
Delaware |
0 |
5349165 |
0 |
5349165 |
5349165 |
8.06 % |
11/01/2021 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
5349165 |
0 |
5349165 |
5349165 |
8.06 % |
11/01/2021 |
| Wellington Management Company LLP |
Delaware |
0 |
5349165 |
0 |
5349165 |
5349165 |
8.06 % |
11/01/2021 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1379603 |
0 |
1379603 |
2.479 % |
11/05/2020 |
| FMR LLC |
Delaware |
142520 |
0 |
1379603 |
0 |
1379603 |
2.479 % |
11/05/2020 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
1379603 |
0 |
1379603 |
2.479 % |
11/05/2020 |
| FMR LLC |
Delaware |
142520 |
0 |
1379603 |
0 |
1379603 |
2.479 % |
11/05/2020 |
| Sands Capital Management, LLC |
Delaware, United States |
|
0 |
3176644 |
0 |
3176644 |
5.7 % |
14/02/2020 |
| Capital Research Global Investors |
Delaware |
6779133 |
0 |
6779133 |
0 |
6779133 |
12.2 % |
14/02/2020 |
| Capital Research Global Investors |
Delaware |
6779133 |
0 |
6779133 |
0 |
6779133 |
12.2 % |
14/02/2020 |
| Capital World Investors |
Delaware |
5266990 |
0 |
5266990 |
0 |
5266990 |
9.5 % |
13/02/2020 |
| Capital World Investors |
Delaware |
5266990 |
0 |
5266990 |
0 |
5266990 |
9.5 % |
13/02/2020 |
| The Vanguard Group |
Pennsylvania |
28342 |
9912 |
3740378 |
30982 |
3771360 |
6.81 % |
12/02/2020 |
| VANGUARD SPECIALIZED FUNDS VANGUARD HEALTH CARE FUND |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
12/02/2020 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
6121442 |
0 |
6121442 |
11.063 % |
07/02/2020 |
| FMR LLC |
Delaware |
792869 |
0 |
6121442 |
0 |
6121442 |
11.063 % |
07/02/2020 |
| BlackRock, Inc. |
Delaware |
2712446 |
0 |
2925336 |
0 |
2925336 |
5.3 % |
05/02/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
7149922 |
0 |
7548613 |
7548613 |
13.64 % |
08/01/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
7149922 |
0 |
7548613 |
7548613 |
13.64 % |
08/01/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
7149922 |
0 |
7548613 |
7548613 |
13.64 % |
08/01/2020 |
| Wellington Management Company LLP |
Delaware |
0 |
6962942 |
0 |
7036185 |
7036185 |
12.72 % |
08/01/2020 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
7149922 |
0 |
7548613 |
7548613 |
13.64 % |
08/01/2020 |
| Wellington Group Holdings LLP |
Delaware |
0 |
7149922 |
0 |
7548613 |
7548613 |
13.64 % |
08/01/2020 |
| Wellington Management Group LLP |
Massachusetts |
0 |
7149922 |
0 |
7548613 |
7548613 |
13.64 % |
08/01/2020 |
| Wellington Management Company LLP |
Delaware |
0 |
6962942 |
0 |
7036185 |
7036185 |
12.72 % |
08/01/2020 |
| Capital International Investors |
California |
2196258 |
0 |
2197573 |
0 |
2197573 |
3.9 % |
10/12/2019 |
| Capital International Investors |
California |
2196258 |
0 |
2197573 |
0 |
2197573 |
3.9 % |
10/12/2019 |
| Capital World Investors |
Delaware |
5607206 |
0 |
5607206 |
0 |
5607206 |
10.1 % |
08/11/2019 |
| Capital World Investors |
Delaware |
5607206 |
0 |
5607206 |
0 |
5607206 |
10.1 % |
08/11/2019 |
| Baillie Gifford & Co |
SCOTLAND UK |
|
0 |
872274 |
0 |
872274 |
1.58 % |
05/11/2019 |
| Baillie Gifford & Co |
SCOTLAND UK |
|
0 |
872274 |
0 |
872274 |
1.58 % |
05/11/2019 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
208302 |
0 |
1271545 |
0 |
1271545 |
2.3 % |
14/02/2019 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
208302 |
0 |
1271545 |
0 |
1271545 |
2.3 % |
14/02/2019 |
| Capital World Investors |
Delaware |
3713572 |
0 |
3713572 |
0 |
3713572 |
6.7 % |
13/02/2019 |
| The Growth Fund of America |
Maryland |
0 |
0 |
0 |
0 |
5195960 |
9.4 % |
13/02/2019 |
| Capital Research Global Investors |
Delaware |
6699431 |
0 |
6699431 |
0 |
6699431 |
12.2 % |
13/02/2019 |
| Capital Research Global Investors |
Delaware |
6699431 |
0 |
6699431 |
0 |
6699431 |
12.2 % |
13/02/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
8204161 |
0 |
8204161 |
14.999 % |
13/02/2019 |
| FMR LLC |
Delaware |
2140400 |
0 |
8204161 |
0 |
8204161 |
14.999 % |
13/02/2019 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
8204161 |
0 |
8204161 |
14.999 % |
13/02/2019 |
| FMR LLC |
Delaware |
2140400 |
0 |
8204161 |
0 |
8204161 |
14.999 % |
13/02/2019 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3502182 |
0 |
7586427 |
7586427 |
13.87 % |
12/02/2019 |
| Wellington Management Company LLP |
Delaware |
0 |
3104013 |
0 |
6775919 |
6775919 |
12.39 % |
12/02/2019 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3502182 |
0 |
7586427 |
7586427 |
13.87 % |
12/02/2019 |
| Wellington Group Holdings LLP |
Delaware |
0 |
3502182 |
0 |
7586427 |
7586427 |
13.87 % |
12/02/2019 |
| The Vanguard Group |
Pennsylvania |
28344 |
8594 |
4764714 |
31843 |
4796557 |
8.76 % |
11/02/2019 |
| BlackRock, Inc. |
Delaware |
2763520 |
0 |
2986142 |
0 |
2986142 |
5.5 % |
04/02/2019 |
| VANGUARD SPECIALIZED FUNDS VANGUARD HEALTH CARE FUND |
Delaware |
2815599 |
|
0 |
0 |
2815599 |
5.14 % |
31/01/2019 |
| Baillie Gifford & Co |
SCOTLAND UK |
2631591 |
0 |
4529123 |
0 |
4529123 |
8.28 % |
24/01/2019 |
| Baillie Gifford & Co |
SCOTLAND UK |
2631591 |
0 |
4529123 |
0 |
4529123 |
8.28 % |
24/01/2019 |
| Capital International Investors |
California |
5284178 |
0 |
5484664 |
0 |
5484664 |
10 % |
10/01/2019 |
| Capital International Investors |
California |
5284178 |
0 |
5484664 |
0 |
5484664 |
10 % |
10/01/2019 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3014254 |
0 |
5760150 |
5760150 |
10.53 % |
13/11/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3014254 |
0 |
5760150 |
5760150 |
10.53 % |
13/11/2018 |
| Wellington Group Holdings LLP |
Delaware |
0 |
3014254 |
0 |
5760150 |
5760150 |
10.53 % |
13/11/2018 |
| Wellington Management Company LLP |
Delaware |
0 |
2632704 |
0 |
5020294 |
5020294 |
9.18 % |
13/11/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
3014254 |
0 |
5760150 |
5760150 |
10.53 % |
13/11/2018 |
| Wellington Group Holdings LLP |
Delaware |
0 |
3014254 |
0 |
5760150 |
5760150 |
10.53 % |
13/11/2018 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
3014254 |
0 |
5760150 |
5760150 |
10.53 % |
13/11/2018 |
| Wellington Management Company LLP |
Delaware |
0 |
2632704 |
0 |
5020294 |
5020294 |
9.18 % |
13/11/2018 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
597605 |
0 |
2857747 |
0 |
2857747 |
5.8 % |
14/02/2018 |
| The Growth Fund of America |
Delaware |
0 |
0 |
0 |
0 |
2661153 |
5.4 % |
13/02/2018 |
| Capital Research Global Investors |
Delaware |
6010817 |
0 |
6010817 |
0 |
6010817 |
12.2 % |
13/02/2018 |
| The Vanguard Group |
Pennsylvania |
69996 |
8177 |
3978712 |
74373 |
4053085 |
8.26 % |
08/02/2018 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2010491 |
0 |
2787618 |
2787618 |
5.69 % |
08/02/2018 |
| Wellington Management Company LLP |
Delaware |
0 |
1810879 |
0 |
2473636 |
2473636 |
5.05 % |
08/02/2018 |
| Wellington Group Holdings LLP |
Delaware |
0 |
2010491 |
0 |
2787618 |
2787618 |
5.69 % |
08/02/2018 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2010491 |
0 |
2787618 |
2787618 |
5.69 % |
08/02/2018 |
| Baillie Gifford & Co |
SCOTLAND UK |
|
0 |
5188435 |
0 |
5188435 |
10.58 % |
31/01/2018 |
| Baillie Gifford & Co |
SCOTLAND UK |
|
0 |
5188435 |
0 |
5188435 |
10.58 % |
31/01/2018 |
| BlackRock, Inc. |
Delaware |
3724808 |
0 |
3831371 |
0 |
3831371 |
7.8 % |
29/01/2018 |
| The Growth Fund of America |
Delaware |
0 |
0 |
0 |
0 |
1854803 |
4.5 % |
14/02/2017 |
| Capital World Investors |
Delaware |
625000 |
0 |
625000 |
0 |
625000 |
1.5 % |
13/02/2017 |
| Capital Research Global Investors |
Delaware |
4713042 |
0 |
4713042 |
0 |
4713042 |
11.6 % |
13/02/2017 |
| The Vanguard Group |
Pennsylvania |
60078 |
3800 |
3011775 |
62178 |
3073953 |
7.57 % |
10/02/2017 |
| Wellington Management Group LLP |
Massachusetts |
0 |
2514874 |
0 |
3049519 |
3049519 |
7.51 % |
09/02/2017 |
| Wellington Management Company LLP |
Delaware |
0 |
2472874 |
0 |
2926206 |
2926206 |
7.21 % |
09/02/2017 |
| Wellington Investment Advisors Holdings LLP |
Delaware |
0 |
2514874 |
0 |
3049519 |
3049519 |
7.51 % |
09/02/2017 |
| Wellington Group Holdings LLP |
Delaware |
0 |
2514874 |
0 |
3049519 |
3049519 |
7.51 % |
09/02/2017 |
| T. ROWE PRICE ASSOCIATES, INC. |
Maryland |
802718 |
0 |
3288161 |
0 |
3288161 |
8.1 % |
07/02/2017 |
| BlackRock, Inc. |
Delaware |
2968291 |
0 |
3059497 |
0 |
3059497 |
7.5 % |
30/01/2017 |
| Baillie Gifford & Co |
SCOTLAND UK |
|
0 |
5164467 |
0 |
5164467 |
12.73 % |
20/01/2017 |
| Baillie Gifford & Co |
SCOTLAND UK |
|
0 |
5164467 |
0 |
5164467 |
12.73 % |
20/01/2017 |
| AQR Capital Management, LLC |
Delaware, USA |
0 |
23509 |
0 |
23509 |
23509 |
0.11 % |
16/02/2016 |
| The Growth Fund of America |
Maryland |
0 |
0 |
0 |
0 |
2352076 |
6.4 % |
12/02/2016 |
| Capital Research Global Investors |
Delaware |
4452741 |
0 |
4452741 |
0 |
4452741 |
12.1 % |
12/02/2016 |
| Capital World Investors |
Delaware |
2075000 |
0 |
2075000 |
0 |
2075000 |
5.6 % |
12/02/2016 |
| T. ROWE PRICE ASSOCIATES, INC. |
MARYLAND |
0 |
0 |
0 |
0 |
2005303 |
5.4 % |
12/02/2016 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
5501537 |
0 |
5501537 |
14.999 % |
12/02/2016 |
| FMR LLC |
Delaware |
812415 |
0 |
5501537 |
0 |
5501537 |
14.999 % |
12/02/2016 |
| Fidelity Growth Company Fund |
Massachusetts |
2401320 |
0 |
0 |
0 |
2401320 |
6.547 % |
12/02/2016 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
5501537 |
0 |
5501537 |
14.999 % |
12/02/2016 |
| FMR LLC |
Delaware |
812415 |
0 |
5501537 |
0 |
5501537 |
14.999 % |
12/02/2016 |
| Fidelity Growth Company Fund |
Massachusetts |
2401320 |
0 |
0 |
0 |
2401320 |
6.547 % |
12/02/2016 |
| The Vanguard Group |
Pennsylvania |
26618 |
1800 |
2345059 |
26518 |
2371577 |
6.46 % |
10/02/2016 |
| Baillie Gifford & Co |
SCOTLAND UK |
|
0 |
4883321 |
0 |
4883321 |
13.31 % |
29/01/2016 |
| BlackRock, Inc. |
Delaware |
1432419 |
0 |
1524056 |
0 |
1524056 |
4.3 % |
10/07/2015 |
| Baillie Gifford & Co |
SCOTLAND UK |
2259899 |
0 |
3697412 |
0 |
3697412 |
10.34 % |
07/07/2015 |
| Baillie Gifford & Co |
SCOTLAND UK |
2259899 |
0 |
3697412 |
0 |
3697412 |
10.34 % |
07/07/2015 |
| Capital Research Global Investors |
Delaware |
3876111 |
0 |
3876111 |
0 |
3876111 |
12.2 % |
13/02/2015 |
| BlackRock, Inc. |
Delaware |
1581379 |
11 |
1627234 |
11 |
1627245 |
5.2 % |
06/02/2015 |
| Coöperatieve AAC LS U.A. |
The Netherlands |
0 |
1251526 |
0 |
1251526 |
1251526 |
5.2 % |
24/02/2014 |
| Forbion 1 Management B.V. |
The Netherlands |
0 |
1251526 |
0 |
1251526 |
1251526 |
5.2 % |
24/02/2014 |
| FMR LLC |
Delaware |
8800 |
0 |
3567031 |
0 |
3567031 |
15 % |
14/02/2014 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
3567031 |
0 |
3567031 |
15 % |
14/02/2014 |
| Capital Research Global Investors |
Delaware |
2612792 |
0 |
2612792 |
0 |
2612792 |
11 % |
12/02/2014 |
| Third Rock Ventures, L.P. |
Delaware |
0 |
3313974 |
0 |
3313974 |
3313974 |
13.9 % |
12/02/2014 |
| TRV GP, LLC |
Delaware |
0 |
3313974 |
0 |
3313974 |
3313974 |
13.9 % |
12/02/2014 |
| Third Rock Ventures GP, L.P. |
Delaware |
0 |
3313974 |
0 |
3313974 |
3313974 |
13.9 % |
12/02/2014 |
| Robert I. Tepper |
United States |
0 |
3313974 |
0 |
3313974 |
3313974 |
13.9 % |
12/02/2014 |
| ARCH Venture Fund VII, L.P. |
Delaware |
0 |
1793588 |
0 |
1793588 |
1793588 |
7.5 % |
06/02/2014 |
| ARCH Venture Partners VII, LLC |
Delaware |
0 |
1793588 |
0 |
1793588 |
1793588 |
7.5 % |
06/02/2014 |
| Keith Crandell |
United States of America |
0 |
1793588 |
0 |
1793588 |
1793588 |
7.5 % |
06/02/2014 |
| Clinton Bybee |
United States of America |
0 |
1793588 |
0 |
1793588 |
1793588 |
7.5 % |
06/02/2014 |
| Robert Nelsen |
United States of America |
0 |
1793588 |
0 |
1793588 |
1793588 |
7.5 % |
06/02/2014 |
| ARCH Venture Partners VII, L.P. |
Delaware |
0 |
1793588 |
0 |
1793588 |
1793588 |
7.5 % |
06/02/2014 |
| Capital Research Global Investors |
Delaware |
2410860 |
0 |
2410860 |
0 |
2410860 |
10.5 % |
12/08/2013 |
| Capital Research Global Investors |
Delaware |
2410860 |
0 |
2410860 |
0 |
2410860 |
10.5 % |
12/08/2013 |
| Capital Research Global Investors |
Delaware |
2410860 |
0 |
2410860 |
0 |
2410860 |
10.5 % |
09/08/2013 |
| Capital Research Global Investors |
Delaware |
2410860 |
0 |
2410860 |
0 |
2410860 |
10.5 % |
09/08/2013 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
3421523 |
0 |
3421523 |
15.001 % |
10/07/2013 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
3421523 |
0 |
3421523 |
15.001 % |
10/07/2013 |
| FMR LLC |
Delaware |
13000 |
0 |
3421523 |
0 |
3421523 |
15.001 % |
10/07/2013 |
| FMR LLC |
Delaware |
13000 |
0 |
3421523 |
0 |
3421523 |
15.001 % |
10/07/2013 |
