| Anand Parekh | United States of America | 0 | 0 | 0 | 0 | 0 | 0 % | 14/11/2024 | 
																					
												| Alyeska Investment Group, L.P. | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/11/2024 | 
																					
												| Alyeska Fund GP, LLC | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 14/11/2024 | 
																					
												| Granahan Investment Management LLC | State of Massachusetts | 0 | 0 | 0 | 0 | 0 | 0 % | 14/11/2024 | 
																					
												| The Vanguard Group | Pennsylvania | 0 | 87543 | 10330825 | 143182 | 10474007 | 5.4 % | 14/11/2024 | 
																					
												| The Vanguard Group | Pennsylvania | 0 | 87543 | 10330825 | 143182 | 10474007 | 5.4 % | 13/11/2024 | 
																					
												| BlackRock, Inc. | Delaware | 15230542 | 0 | 15443767 | 0 | 15443767 | 8 % | 08/11/2024 | 
																					
												| The Vanguard Group | Pennsylvania | 0 | 87543 | 10330825 | 143182 | 10474007 | 5.4 % | 04/11/2024 | 
																					
												| The Vanguard Group | Pennsylvania | 0 | 87543 | 10330825 | 143182 | 10474007 | 5.4 % | 04/11/2024 | 
																					
												| BlackRock, Inc. | Delaware | 0 | 0 | 15443767 | 0 | 15443767 | 8 % | 22/10/2024 | 
																					
												| PFM Health Sciences GP, LLC | Delaware | 0 | 2042651 | 0 | 2042651 | 2042651 | 1.9 % | 14/02/2024 | 
																					
												| Partner Asset Management, LLC | Delaware | 0 | 2042651 | 0 | 2042651 | 2042651 | 1.9 % | 14/02/2024 | 
																					
												| Brian D. Grossman | U.S. Citizen | 0 | 2042651 | 0 | 2042651 | 2042651 | 1.9 % | 14/02/2024 | 
																					
												| PFM Health Sciences, LP | Delaware | 0 | 2042651 | 0 | 2042651 | 2042651 | 1.9 % | 14/02/2024 | 
																					
												| Kevin Tang | united states |  | 1700000 | 0 | 1700000 | 1700000 | 0.9 % | 14/02/2024 | 
																					
												| TANG CAPITAL PARTNERS, LP | DELAWARE |  | 1700000 | 0 | 1700000 | 1700000 | 0.9 % | 14/02/2024 | 
																					
												| Kevin Tang | united states |  | 1700000 | 0 | 1700000 | 1700000 | 0.9 % | 14/02/2024 | 
																					
												| Tang Capital Management, LLC | DELAWARE |  | 1700000 | 0 | 1700000 | 1700000 | 0.9 % | 14/02/2024 | 
																					
												| TANG CAPITAL PARTNERS, LP | DELAWARE |  | 1700000 | 0 | 1700000 | 1700000 | 0.9 % | 14/02/2024 | 
																					
												| Tang Capital Management, LLC | DELAWARE |  | 1700000 | 0 | 1700000 | 1700000 | 0.9 % | 14/02/2024 | 
																					
												| Alyeska Fund GP, LLC | Delaware | 0 | 6912502 | 0 | 6912502 | 0 | 6.32 % | 14/02/2024 | 
																					
												| Alyeska Investment Group, L.P. | Delaware | 0 | 6912502 | 0 | 6912502 | 0 | 6.32 % | 14/02/2024 | 
																					
												| Anand Parekh | United States of America | 0 | 6912502 | 0 | 6912502 | 0 | 6.32 % | 14/02/2024 | 
																					
												| Granahan Investment Management LLC | State of Massachusetts | 6741868 | 0 | 8077697 | 0 | 8077697 | 7.38 % | 14/02/2024 | 
																					
												| Granahan Investment Management LLC | State of Massachusetts | 6741868 | 0 | 8077697 | 0 | 8077697 | 7.38 % | 14/02/2024 | 
																					
												| SSGA FUNDS MANAGEMENT, INC. | BOSTON, MASSACHUSETTS | 0 | 11895595 | 0 | 11909995 | 11909995 | 6.26 % | 25/01/2024 | 
																					
												| STATE STREET CORPORATION | BOSTON, MASSACHUSETTS | 0 | 13756321 | 0 | 13865719 | 13865719 | 7.28 % | 25/01/2024 | 
																					
												| BlackRock, Inc. | Delaware | 8832224 | 0 | 8983001 | 0 | 8983001 | 4.7 % | 08/01/2024 | 
																					
												| PFM Health Sciences, LP | Delaware | 0 | 6021843 | 0 | 6021843 | 6021843 | 5.7 % | 21/04/2023 | 
																					
												| PFM Health Sciences, LP | Delaware | 0 | 6021843 | 0 | 6021843 | 6021843 | 5.7 % | 21/04/2023 | 
																					
												| PFM Health Sciences GP, LLC | Delaware | 0 | 6021843 | 0 | 6021843 | 6021843 | 5.7 % | 21/04/2023 | 
																					
												| Partner Asset Management, LLC | Delaware | 0 | 6021843 | 0 | 6021843 | 6021843 | 5.7 % | 21/04/2023 | 
																					
												| Brian D. Grossman | U.S. Citizen | 0 | 6021843 | 0 | 6021843 | 6021843 | 5.7 % | 21/04/2023 | 
																					
												| Brian D. Grossman | U.S. Citizen | 0 | 6021843 | 0 | 6021843 | 6021843 | 5.7 % | 21/04/2023 | 
																					
												| Partner Asset Management, LLC | Delaware | 0 | 6021843 | 0 | 6021843 | 6021843 | 5.7 % | 21/04/2023 | 
																					
												| PFM Health Sciences GP, LLC | Delaware | 0 | 6021843 | 0 | 6021843 | 6021843 | 5.7 % | 21/04/2023 | 
																					
												| STATE STREET CORPORATION | BOSTON, MASSACHUSETTS | 0 | 11579272 | 0 | 11683114 | 11683114 | 11.03 % | 10/03/2023 | 
																					
												| SSGA FUNDS MANAGEMENT, INC. | BOSTON, MASSACHUSETTS | 0 | 9995131 | 0 | 10009531 | 10009531 | 9.45 % | 10/03/2023 | 
																					
												| The Vanguard Group | Pennsylvania | 0 | 61259 | 4138335 | 127985 | 4266320 | 5.15 % | 09/02/2023 | 
																					
												| First Trust Advisors L.P.  The Charger Corporation | Illinois, U.S.A. | 0 | 0 | 0 | 0 | 0 | 0 % | 03/02/2023 | 
																					
												| First Trust Advisors L.P.  The Charger Corporation | Illinois, U.S.A. | 0 | 0 | 0 | 0 | 0 | 0 % | 03/02/2023 | 
																					
												| BlackRock, Inc. | Delaware | 7110236 | 0 | 7367181 | 0 | 7367181 | 8.9 % | 25/01/2023 | 
																					
												| Millennium Group Management LLC |  |  |  |  |  | 973085 | 1.2 % | 12/01/2023 | 
																					
												| Millennium Management LLC |  |  |  |  |  | 973085 | 1.2 % | 12/01/2023 | 
																					
												| Israel A. Englander |  |  |  |  |  | 973085 | 1.2 % | 12/01/2023 | 
																					
												| Millennium Management LLC |  |  |  |  |  | 973085 | 1.2 % | 12/01/2023 | 
																					
												| Millennium Group Management LLC |  |  |  |  |  | 973085 | 1.2 % | 12/01/2023 | 
																					
												| Israel A. Englander |  |  |  |  |  | 973085 | 1.2 % | 12/01/2023 | 
																					
												| SSGA FUNDS MANAGEMENT, INC. | BOSTON, MASSACHUSETTS | 0 | 11132385 | 0 | 11146785 | 11146785 | 14.45 % | 11/10/2022 | 
																					
												| STATE STREET CORPORATION | BOSTON, MASSACHUSETTS | 0 | 12643238 | 0 | 12720480 | 12720480 | 16.49 % | 11/10/2022 | 
																					
												| Wellington Group Holdings LLP | Delaware | 0 | 235790 | 0 | 244061 | 244061 | 0.32 % | 09/09/2022 | 
																					
												| Wellington Management Group LLP | Massachusetts | 0 | 235790 | 0 | 244061 | 244061 | 0.32 % | 09/09/2022 | 
																					
												| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 235790 | 0 | 244061 | 244061 | 0.32 % | 09/09/2022 | 
																					
												| Millennium Management LLC |  |  |  |  |  | 3873900 | 5.4 % | 01/08/2022 | 
																					
												| Millennium Group Management LLC |  |  |  |  |  | 3873900 | 5.4 % | 01/08/2022 | 
																					
												| Millennium Management LLC |  |  |  |  |  | 3873900 | 5.4 % | 01/08/2022 | 
																					
												| Millennium Group Management LLC |  |  |  |  |  | 3873900 | 5.4 % | 01/08/2022 | 
																					
												| Israel A. Englander |  |  |  |  |  | 3873900 | 5.4 % | 01/08/2022 | 
																					
												| Israel A. Englander |  |  |  |  |  | 3873900 | 5.4 % | 01/08/2022 | 
																					
												| The Vanguard Group | Pennsylvania | 0 | 36345 | 3445499 | 61410 | 3506909 | 4.91 % | 11/07/2022 | 
																					
												| The Vanguard Group | Pennsylvania | 0 | 36345 | 3445499 | 61410 | 3506909 | 4.91 % | 11/07/2022 | 
																					
												| STATE STREET CORPORATION | BOSTON, MASSACHUSETTS | 0 | 1746465 | 0 | 1825101 | 1825101 | 2.55 % | 11/07/2022 | 
																					
												| TANG CAPITAL PARTNERS, LP | DELAWARE |  | 3721056 | 0 | 3721056 | 3721056 | 5.2 % | 03/06/2022 | 
																					
												| Kevin Tang | united states |  | 3721056 | 0 | 3721056 | 3721056 | 5.2 % | 03/06/2022 | 
																					
												| Tang Capital Management, LLC | DELAWARE |  | 3721056 | 0 | 3721056 | 3721056 | 5.2 % | 03/06/2022 | 
																					
												| TANG CAPITAL PARTNERS, LP | DELAWARE |  | 3721056 | 0 | 3721056 | 3721056 | 5.2 % | 03/06/2022 | 
																					
												| Tang Capital Management, LLC | DELAWARE |  | 3721056 | 0 | 3721056 | 3721056 | 5.2 % | 03/06/2022 | 
																					
												| Kevin Tang | united states |  | 3721056 | 0 | 3721056 | 3721056 | 5.2 % | 03/06/2022 | 
																					
												| STATE STREET CORPORATION | BOSTON, MASSACHUSETTS | 0 | 13013070 | 0 | 13151891 | 13151891 | 18.41 % | 11/04/2022 | 
																					
												| SSGA FUNDS MANAGEMENT, INC. | BOSTON, MASSACHUSETTS | 0 | 11868400 | 0 | 11882800 | 11882800 | 16.63 % | 11/04/2022 | 
																					
												| The Vanguard Group | Pennsylvania | 0 | 53838 | 7120948 | 112642 | 7233590 | 10.32 % | 09/02/2022 | 
																					
												| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 6140000 | 0 | 6140000 | 6140000 | 8.76 % | 04/02/2022 | 
																					
												| Wellington Management Company LLP | Delaware | 0 | 6140000 | 0 | 6140000 | 6140000 | 8.76 % | 04/02/2022 | 
																					
												| Wellington Management Group LLP | Massachusetts | 0 | 6140000 | 0 | 6140000 | 6140000 | 8.76 % | 04/02/2022 | 
																					
												| Wellington Group Holdings LLP | Delaware | 0 | 6140000 | 0 | 6140000 | 6140000 | 8.76 % | 04/02/2022 | 
																					
												| BlackRock, Inc. | Delaware | 5747306 | 0 | 5912002 | 0 | 5912002 | 8.4 % | 02/02/2022 | 
																					
												| First Trust Advisors L.P.  The Charger Corporation | Illinois, U.S.A. | 0 | 0 | 0 | 0 | 5204825 | 7.42 % | 26/01/2022 | 
																					
												| First Trust Advisors L.P.  The Charger Corporation | Illinois, U.S.A. | 0 | 0 | 0 | 0 | 5204825 | 7.42 % | 26/01/2022 | 
																					
												| SSGA FUNDS MANAGEMENT, INC. | BOSTON, MASSACHUSETTS | 0 | 6376057 | 0 | 6390457 | 6390457 | 9.12 % | 10/01/2022 | 
																					
												| STATE STREET CORPORATION | BOSTON, MASSACHUSETTS | 0 | 7478489 | 0 | 7617310 | 7617310 | 10.87 % | 10/01/2022 | 
																					
												| The Vanguard Group | Pennsylvania | 0 | 46707 | 6694305 | 103214 | 6797519 | 10.12 % | 12/04/2021 | 
																					
												| The Vanguard Group | Pennsylvania | 0 | 46707 | 6694305 | 103214 | 6797519 | 10.12 % | 12/04/2021 | 
																					
												| Capital Research Global Investors | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 10/03/2021 | 
																					
												| Capital Research Global Investors | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 10/03/2021 | 
																					
												| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 6850320 | 0 | 6915454 | 6915454 | 10.3 % | 10/03/2021 | 
																					
												| Wellington Management Company LLP | Delaware | 0 | 6850320 | 0 | 6850320 | 6850320 | 10.2 % | 10/03/2021 | 
																					
												| Wellington Management Group LLP | Massachusetts | 0 | 6850320 | 0 | 6915454 | 6915454 | 10.3 % | 10/03/2021 | 
																					
												| Wellington Management Group LLP | Massachusetts | 0 | 6850320 | 0 | 6915454 | 6915454 | 10.3 % | 10/03/2021 | 
																					
												| Wellington Group Holdings LLP | Delaware | 0 | 6850320 | 0 | 6915454 | 6915454 | 10.3 % | 10/03/2021 | 
																					
												| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 6850320 | 0 | 6915454 | 6915454 | 10.3 % | 10/03/2021 | 
																					
												| Wellington Management Company LLP | Delaware | 0 | 6850320 | 0 | 6850320 | 6850320 | 10.2 % | 10/03/2021 | 
																					
												| Wellington Group Holdings LLP | Delaware | 0 | 6850320 | 0 | 6915454 | 6915454 | 10.3 % | 10/03/2021 | 
																					
												| Capital Research Global Investors | Delaware | 8128284 | 0 | 8128284 | 0 | 8128284 | 12.2 % | 16/02/2021 | 
																					
												| Capital Research Global Investors | Delaware | 8128284 | 0 | 8128284 | 0 | 8128284 | 12.2 % | 16/02/2021 | 
																					
												| Capital World Investors | Delaware | 3127163 | 0 | 3127163 | 0 | 3127163 | 4.7 % | 16/02/2021 | 
																					
												| Capital World Investors | Delaware | 3127163 | 0 | 3127163 | 0 | 3127163 | 4.7 % | 16/02/2021 | 
																					
												| Sands Capital Management, LLC | Delaware, United States |  | 0 | 3163651 | 0 | 3163651 | 4.77 % | 16/02/2021 | 
																					
												| The Vanguard Group | Pennsylvania | 0 | 47357 | 6364196 | 99036 | 6463232 | 9.74 % | 10/02/2021 | 
																					
												| BlackRock, Inc. | Delaware | 3622760 | 0 | 3861648 | 0 | 3861648 | 5.8 % | 28/01/2021 | 
																					
												| Wellington Group Holdings LLP | Delaware | 0 | 5349165 | 0 | 5349165 | 5349165 | 8.06 % | 11/01/2021 | 
																					
												| Wellington Management Group LLP | Massachusetts | 0 | 5349165 | 0 | 5349165 | 5349165 | 8.06 % | 11/01/2021 | 
																					
												| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 5349165 | 0 | 5349165 | 5349165 | 8.06 % | 11/01/2021 | 
																					
												| Wellington Management Company LLP | Delaware | 0 | 5349165 | 0 | 5349165 | 5349165 | 8.06 % | 11/01/2021 | 
																					
												| Wellington Management Group LLP | Massachusetts | 0 | 5349165 | 0 | 5349165 | 5349165 | 8.06 % | 11/01/2021 | 
																					
												| Wellington Group Holdings LLP | Delaware | 0 | 5349165 | 0 | 5349165 | 5349165 | 8.06 % | 11/01/2021 | 
																					
												| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 5349165 | 0 | 5349165 | 5349165 | 8.06 % | 11/01/2021 | 
																					
												| Wellington Management Company LLP | Delaware | 0 | 5349165 | 0 | 5349165 | 5349165 | 8.06 % | 11/01/2021 | 
																					
												| Abigail P. Johnson | United States of America | 0 | 0 | 1379603 | 0 | 1379603 | 2.479 % | 11/05/2020 | 
																					
												| FMR LLC | Delaware | 142520 | 0 | 1379603 | 0 | 1379603 | 2.479 % | 11/05/2020 | 
																					
												| Abigail P. Johnson | United States of America | 0 | 0 | 1379603 | 0 | 1379603 | 2.479 % | 11/05/2020 | 
																					
												| FMR LLC | Delaware | 142520 | 0 | 1379603 | 0 | 1379603 | 2.479 % | 11/05/2020 | 
																					
												| Sands Capital Management, LLC | Delaware, United States |  | 0 | 3176644 | 0 | 3176644 | 5.7 % | 14/02/2020 | 
																					
												| Capital Research Global Investors | Delaware | 6779133 | 0 | 6779133 | 0 | 6779133 | 12.2 % | 14/02/2020 | 
																					
												| Capital Research Global Investors | Delaware | 6779133 | 0 | 6779133 | 0 | 6779133 | 12.2 % | 14/02/2020 | 
																					
												| Capital World Investors | Delaware | 5266990 | 0 | 5266990 | 0 | 5266990 | 9.5 % | 13/02/2020 | 
																					
												| Capital World Investors | Delaware | 5266990 | 0 | 5266990 | 0 | 5266990 | 9.5 % | 13/02/2020 | 
																					
												| The Vanguard Group | Pennsylvania | 28342 | 9912 | 3740378 | 30982 | 3771360 | 6.81 % | 12/02/2020 | 
																					
												| VANGUARD SPECIALIZED FUNDS VANGUARD HEALTH CARE FUND | Delaware | 0 | 0 | 0 | 0 | 0 | 0 % | 12/02/2020 | 
																					
												| Abigail P. Johnson | United States of America | 0 | 0 | 6121442 | 0 | 6121442 | 11.063 % | 07/02/2020 | 
																					
												| FMR LLC | Delaware | 792869 | 0 | 6121442 | 0 | 6121442 | 11.063 % | 07/02/2020 | 
																					
												| BlackRock, Inc. | Delaware | 2712446 | 0 | 2925336 | 0 | 2925336 | 5.3 % | 05/02/2020 | 
																					
												| Wellington Group Holdings LLP | Delaware | 0 | 7149922 | 0 | 7548613 | 7548613 | 13.64 % | 08/01/2020 | 
																					
												| Wellington Management Group LLP | Massachusetts | 0 | 7149922 | 0 | 7548613 | 7548613 | 13.64 % | 08/01/2020 | 
																					
												| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 7149922 | 0 | 7548613 | 7548613 | 13.64 % | 08/01/2020 | 
																					
												| Wellington Management Company LLP | Delaware | 0 | 6962942 | 0 | 7036185 | 7036185 | 12.72 % | 08/01/2020 | 
																					
												| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 7149922 | 0 | 7548613 | 7548613 | 13.64 % | 08/01/2020 | 
																					
												| Wellington Group Holdings LLP | Delaware | 0 | 7149922 | 0 | 7548613 | 7548613 | 13.64 % | 08/01/2020 | 
																					
												| Wellington Management Group LLP | Massachusetts | 0 | 7149922 | 0 | 7548613 | 7548613 | 13.64 % | 08/01/2020 | 
																					
												| Wellington Management Company LLP | Delaware | 0 | 6962942 | 0 | 7036185 | 7036185 | 12.72 % | 08/01/2020 | 
																					
												| Capital International Investors | California | 2196258 | 0 | 2197573 | 0 | 2197573 | 3.9 % | 10/12/2019 | 
																					
												| Capital International Investors | California | 2196258 | 0 | 2197573 | 0 | 2197573 | 3.9 % | 10/12/2019 | 
																					
												| Capital World Investors | Delaware | 5607206 | 0 | 5607206 | 0 | 5607206 | 10.1 % | 08/11/2019 | 
																					
												| Capital World Investors | Delaware | 5607206 | 0 | 5607206 | 0 | 5607206 | 10.1 % | 08/11/2019 | 
																					
												| Baillie Gifford & Co | SCOTLAND UK |  | 0 | 872274 | 0 | 872274 | 1.58 % | 05/11/2019 | 
																					
												| Baillie Gifford & Co | SCOTLAND UK |  | 0 | 872274 | 0 | 872274 | 1.58 % | 05/11/2019 | 
																					
												| T. ROWE PRICE ASSOCIATES, INC. | Maryland | 208302 | 0 | 1271545 | 0 | 1271545 | 2.3 % | 14/02/2019 | 
																					
												| T. ROWE PRICE ASSOCIATES, INC. | Maryland | 208302 | 0 | 1271545 | 0 | 1271545 | 2.3 % | 14/02/2019 | 
																					
												| Capital World Investors | Delaware | 3713572 | 0 | 3713572 | 0 | 3713572 | 6.7 % | 13/02/2019 | 
																					
												| The Growth Fund of America | Maryland | 0 | 0 | 0 | 0 | 5195960 | 9.4 % | 13/02/2019 | 
																					
												| Capital Research Global Investors | Delaware | 6699431 | 0 | 6699431 | 0 | 6699431 | 12.2 % | 13/02/2019 | 
																					
												| Capital Research Global Investors | Delaware | 6699431 | 0 | 6699431 | 0 | 6699431 | 12.2 % | 13/02/2019 | 
																					
												| Abigail P. Johnson | United States of America | 0 | 0 | 8204161 | 0 | 8204161 | 14.999 % | 13/02/2019 | 
																					
												| FMR LLC | Delaware | 2140400 | 0 | 8204161 | 0 | 8204161 | 14.999 % | 13/02/2019 | 
																					
												| Abigail P. Johnson | United States of America | 0 | 0 | 8204161 | 0 | 8204161 | 14.999 % | 13/02/2019 | 
																					
												| FMR LLC | Delaware | 2140400 | 0 | 8204161 | 0 | 8204161 | 14.999 % | 13/02/2019 | 
																					
												| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 3502182 | 0 | 7586427 | 7586427 | 13.87 % | 12/02/2019 | 
																					
												| Wellington Management Company LLP | Delaware | 0 | 3104013 | 0 | 6775919 | 6775919 | 12.39 % | 12/02/2019 | 
																					
												| Wellington Management Group LLP | Massachusetts | 0 | 3502182 | 0 | 7586427 | 7586427 | 13.87 % | 12/02/2019 | 
																					
												| Wellington Group Holdings LLP | Delaware | 0 | 3502182 | 0 | 7586427 | 7586427 | 13.87 % | 12/02/2019 | 
																					
												| The Vanguard Group | Pennsylvania | 28344 | 8594 | 4764714 | 31843 | 4796557 | 8.76 % | 11/02/2019 | 
																					
												| BlackRock, Inc. | Delaware | 2763520 | 0 | 2986142 | 0 | 2986142 | 5.5 % | 04/02/2019 | 
																					
												| VANGUARD SPECIALIZED FUNDS VANGUARD HEALTH CARE FUND | Delaware | 2815599 |  | 0 | 0 | 2815599 | 5.14 % | 31/01/2019 | 
																					
												| Baillie Gifford & Co | SCOTLAND UK | 2631591 | 0 | 4529123 | 0 | 4529123 | 8.28 % | 24/01/2019 | 
																					
												| Baillie Gifford & Co | SCOTLAND UK | 2631591 | 0 | 4529123 | 0 | 4529123 | 8.28 % | 24/01/2019 | 
																					
												| Capital International Investors | California | 5284178 | 0 | 5484664 | 0 | 5484664 | 10 % | 10/01/2019 | 
																					
												| Capital International Investors | California | 5284178 | 0 | 5484664 | 0 | 5484664 | 10 % | 10/01/2019 | 
																					
												| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 3014254 | 0 | 5760150 | 5760150 | 10.53 % | 13/11/2018 | 
																					
												| Wellington Management Group LLP | Massachusetts | 0 | 3014254 | 0 | 5760150 | 5760150 | 10.53 % | 13/11/2018 | 
																					
												| Wellington Group Holdings LLP | Delaware | 0 | 3014254 | 0 | 5760150 | 5760150 | 10.53 % | 13/11/2018 | 
																					
												| Wellington Management Company LLP | Delaware | 0 | 2632704 | 0 | 5020294 | 5020294 | 9.18 % | 13/11/2018 | 
																					
												| Wellington Management Group LLP | Massachusetts | 0 | 3014254 | 0 | 5760150 | 5760150 | 10.53 % | 13/11/2018 | 
																					
												| Wellington Group Holdings LLP | Delaware | 0 | 3014254 | 0 | 5760150 | 5760150 | 10.53 % | 13/11/2018 | 
																					
												| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 3014254 | 0 | 5760150 | 5760150 | 10.53 % | 13/11/2018 | 
																					
												| Wellington Management Company LLP | Delaware | 0 | 2632704 | 0 | 5020294 | 5020294 | 9.18 % | 13/11/2018 | 
																					
												| T. ROWE PRICE ASSOCIATES, INC. | Maryland | 597605 | 0 | 2857747 | 0 | 2857747 | 5.8 % | 14/02/2018 | 
																					
												| The Growth Fund of America | Delaware | 0 | 0 | 0 | 0 | 2661153 | 5.4 % | 13/02/2018 | 
																					
												| Capital Research Global Investors | Delaware | 6010817 | 0 | 6010817 | 0 | 6010817 | 12.2 % | 13/02/2018 | 
																					
												| The Vanguard Group | Pennsylvania | 69996 | 8177 | 3978712 | 74373 | 4053085 | 8.26 % | 08/02/2018 | 
																					
												| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 2010491 | 0 | 2787618 | 2787618 | 5.69 % | 08/02/2018 | 
																					
												| Wellington Management Company LLP | Delaware | 0 | 1810879 | 0 | 2473636 | 2473636 | 5.05 % | 08/02/2018 | 
																					
												| Wellington Group Holdings LLP | Delaware | 0 | 2010491 | 0 | 2787618 | 2787618 | 5.69 % | 08/02/2018 | 
																					
												| Wellington Management Group LLP | Massachusetts | 0 | 2010491 | 0 | 2787618 | 2787618 | 5.69 % | 08/02/2018 | 
																					
												| Baillie Gifford & Co | SCOTLAND UK |  | 0 | 5188435 | 0 | 5188435 | 10.58 % | 31/01/2018 | 
																					
												| Baillie Gifford & Co | SCOTLAND UK |  | 0 | 5188435 | 0 | 5188435 | 10.58 % | 31/01/2018 | 
																					
												| BlackRock, Inc. | Delaware | 3724808 | 0 | 3831371 | 0 | 3831371 | 7.8 % | 29/01/2018 | 
																					
												| The Growth Fund of America | Delaware | 0 | 0 | 0 | 0 | 1854803 | 4.5 % | 14/02/2017 | 
																					
												| Capital World Investors | Delaware | 625000 | 0 | 625000 | 0 | 625000 | 1.5 % | 13/02/2017 | 
																					
												| Capital Research Global Investors | Delaware | 4713042 | 0 | 4713042 | 0 | 4713042 | 11.6 % | 13/02/2017 | 
																					
												| The Vanguard Group | Pennsylvania | 60078 | 3800 | 3011775 | 62178 | 3073953 | 7.57 % | 10/02/2017 | 
																					
												| Wellington Management Group LLP | Massachusetts | 0 | 2514874 | 0 | 3049519 | 3049519 | 7.51 % | 09/02/2017 | 
																					
												| Wellington Management Company LLP | Delaware | 0 | 2472874 | 0 | 2926206 | 2926206 | 7.21 % | 09/02/2017 | 
																					
												| Wellington Investment Advisors Holdings LLP | Delaware | 0 | 2514874 | 0 | 3049519 | 3049519 | 7.51 % | 09/02/2017 | 
																					
												| Wellington Group Holdings LLP | Delaware | 0 | 2514874 | 0 | 3049519 | 3049519 | 7.51 % | 09/02/2017 | 
																					
												| T. ROWE PRICE ASSOCIATES, INC. | Maryland | 802718 | 0 | 3288161 | 0 | 3288161 | 8.1 % | 07/02/2017 | 
																					
												| BlackRock, Inc. | Delaware | 2968291 | 0 | 3059497 | 0 | 3059497 | 7.5 % | 30/01/2017 | 
																					
												| Baillie Gifford & Co | SCOTLAND UK |  | 0 | 5164467 | 0 | 5164467 | 12.73 % | 20/01/2017 | 
																					
												| Baillie Gifford & Co | SCOTLAND UK |  | 0 | 5164467 | 0 | 5164467 | 12.73 % | 20/01/2017 | 
																					
												| AQR Capital Management, LLC | Delaware, USA | 0 | 23509 | 0 | 23509 | 23509 | 0.11 % | 16/02/2016 | 
																					
												| The Growth Fund of America | Maryland | 0 | 0 | 0 | 0 | 2352076 | 6.4 % | 12/02/2016 | 
																					
												| Capital Research Global Investors | Delaware | 4452741 | 0 | 4452741 | 0 | 4452741 | 12.1 % | 12/02/2016 | 
																					
												| Capital World Investors | Delaware | 2075000 | 0 | 2075000 | 0 | 2075000 | 5.6 % | 12/02/2016 | 
																					
												| T. ROWE PRICE ASSOCIATES, INC. | MARYLAND | 0 | 0 | 0 | 0 | 2005303 | 5.4 % | 12/02/2016 | 
																					
												| Abigail P. Johnson | United States of America | 0 | 0 | 5501537 | 0 | 5501537 | 14.999 % | 12/02/2016 | 
																					
												| FMR LLC | Delaware | 812415 | 0 | 5501537 | 0 | 5501537 | 14.999 % | 12/02/2016 | 
																					
												| Fidelity Growth Company Fund | Massachusetts | 2401320 | 0 | 0 | 0 | 2401320 | 6.547 % | 12/02/2016 | 
																					
												| Abigail P. Johnson | United States of America | 0 | 0 | 5501537 | 0 | 5501537 | 14.999 % | 12/02/2016 | 
																					
												| FMR LLC | Delaware | 812415 | 0 | 5501537 | 0 | 5501537 | 14.999 % | 12/02/2016 | 
																					
												| Fidelity Growth Company Fund | Massachusetts | 2401320 | 0 | 0 | 0 | 2401320 | 6.547 % | 12/02/2016 | 
																					
												| The Vanguard Group | Pennsylvania | 26618 | 1800 | 2345059 | 26518 | 2371577 | 6.46 % | 10/02/2016 | 
																					
												| Baillie Gifford & Co | SCOTLAND UK |  | 0 | 4883321 | 0 | 4883321 | 13.31 % | 29/01/2016 | 
																					
												| BlackRock, Inc. | Delaware | 1432419 | 0 | 1524056 | 0 | 1524056 | 4.3 % | 10/07/2015 | 
																					
												| Baillie Gifford & Co | SCOTLAND UK | 2259899 | 0 | 3697412 | 0 | 3697412 | 10.34 % | 07/07/2015 | 
																					
												| Baillie Gifford & Co | SCOTLAND UK | 2259899 | 0 | 3697412 | 0 | 3697412 | 10.34 % | 07/07/2015 | 
																					
												| Capital Research Global Investors | Delaware | 3876111 | 0 | 3876111 | 0 | 3876111 | 12.2 % | 13/02/2015 | 
																					
												| BlackRock, Inc. | Delaware | 1581379 | 11 | 1627234 | 11 | 1627245 | 5.2 % | 06/02/2015 | 
																					
												| Coöperatieve AAC LS U.A. | The Netherlands | 0 | 1251526 | 0 | 1251526 | 1251526 | 5.2 % | 24/02/2014 | 
																					
												| Forbion 1 Management B.V. | The Netherlands | 0 | 1251526 | 0 | 1251526 | 1251526 | 5.2 % | 24/02/2014 | 
																					
												| FMR LLC | Delaware | 8800 | 0 | 3567031 | 0 | 3567031 | 15 % | 14/02/2014 | 
																					
												| Edward C. Johnson 3d | United States of America | 0 | 0 | 3567031 | 0 | 3567031 | 15 % | 14/02/2014 | 
																					
												| Capital Research Global Investors | Delaware | 2612792 | 0 | 2612792 | 0 | 2612792 | 11 % | 12/02/2014 | 
																					
												| Third Rock Ventures, L.P. | Delaware | 0 | 3313974 | 0 | 3313974 | 3313974 | 13.9 % | 12/02/2014 | 
																					
												| TRV GP, LLC | Delaware | 0 | 3313974 | 0 | 3313974 | 3313974 | 13.9 % | 12/02/2014 | 
																					
												| Third Rock Ventures GP, L.P. | Delaware | 0 | 3313974 | 0 | 3313974 | 3313974 | 13.9 % | 12/02/2014 | 
																					
												| Robert I. Tepper | United States | 0 | 3313974 | 0 | 3313974 | 3313974 | 13.9 % | 12/02/2014 | 
																					
												| ARCH Venture Fund VII, L.P. | Delaware | 0 | 1793588 | 0 | 1793588 | 1793588 | 7.5 % | 06/02/2014 | 
																					
												| ARCH Venture Partners VII, LLC | Delaware | 0 | 1793588 | 0 | 1793588 | 1793588 | 7.5 % | 06/02/2014 | 
																					
												| Keith Crandell | United States of America | 0 | 1793588 | 0 | 1793588 | 1793588 | 7.5 % | 06/02/2014 | 
																					
												| Clinton Bybee | United States of America | 0 | 1793588 | 0 | 1793588 | 1793588 | 7.5 % | 06/02/2014 | 
																					
												| Robert Nelsen | United States of America | 0 | 1793588 | 0 | 1793588 | 1793588 | 7.5 % | 06/02/2014 | 
																					
												| ARCH Venture Partners VII, L.P. | Delaware | 0 | 1793588 | 0 | 1793588 | 1793588 | 7.5 % | 06/02/2014 | 
																					
												| Capital Research Global Investors | Delaware | 2410860 | 0 | 2410860 | 0 | 2410860 | 10.5 % | 12/08/2013 | 
																					
												| Capital Research Global Investors | Delaware | 2410860 | 0 | 2410860 | 0 | 2410860 | 10.5 % | 12/08/2013 | 
																					
												| Capital Research Global Investors | Delaware | 2410860 | 0 | 2410860 | 0 | 2410860 | 10.5 % | 09/08/2013 | 
																					
												| Capital Research Global Investors | Delaware | 2410860 | 0 | 2410860 | 0 | 2410860 | 10.5 % | 09/08/2013 | 
																					
												| Edward C. Johnson 3d | United States of America | 0 | 0 | 3421523 | 0 | 3421523 | 15.001 % | 10/07/2013 | 
																					
												| Edward C. Johnson 3d | United States of America | 0 | 0 | 3421523 | 0 | 3421523 | 15.001 % | 10/07/2013 | 
																					
												| FMR LLC | Delaware | 13000 | 0 | 3421523 | 0 | 3421523 | 15.001 % | 10/07/2013 | 
																					
												| FMR LLC | Delaware | 13000 | 0 | 3421523 | 0 | 3421523 | 15.001 % | 10/07/2013 |