| M. Kingdon Offshore Master Fund L.P. |
Cayman Islands |
0 |
81000 |
0 |
81000 |
81000 |
1.4 % |
13/11/2024 |
| Mark Kingdon |
United States of America |
0 |
90000 |
0 |
90000 |
90000 |
1.5 % |
13/11/2024 |
| Kingdon Capital Management, L.L.C. |
Delaware |
0 |
90000 |
0 |
90000 |
90000 |
1.5 % |
13/11/2024 |
| Kingdon GP, LLC |
Delaware |
0 |
81000 |
0 |
81000 |
81000 |
1.4 % |
13/11/2024 |
| Thomas A. Satterfield, Jr. |
United States of America |
137930 |
552502 |
137930 |
552502 |
690432 |
8.05 % |
01/11/2024 |
| Maverick Capital, Ltd. |
Texas |
0 |
582273 |
0 |
582273 |
582273 |
9.9 % |
14/02/2024 |
| Maverick Capital Management, LLC |
Texas |
0 |
582273 |
0 |
582273 |
582273 |
9.9 % |
14/02/2024 |
| Lee S. Ainslie III |
United States of America |
0 |
582273 |
0 |
582273 |
582273 |
9.9 % |
14/02/2024 |
| Marc Elia |
United States |
0 |
421951 |
0 |
421951 |
421951 |
7.2 % |
12/02/2024 |
| M28 Capital Management LP |
Delaware |
0 |
421951 |
0 |
421951 |
421951 |
7.2 % |
12/02/2024 |
| Maverick Capital Management, LLC – |
Texas |
0 |
5555598 |
0 |
5555598 |
5555598 |
5.8 % |
14/02/2023 |
| Lee S. Ainslie III |
United States of America |
0 |
5555598 |
0 |
5555598 |
5555598 |
5.8 % |
14/02/2023 |
| Maverick Capital, Ltd. – |
Texas |
0 |
5555598 |
0 |
5555598 |
5555598 |
5.8 % |
14/02/2023 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
255009 |
0 |
255009 |
255009 |
0.26 % |
20/01/2023 |
| BlackRock, Inc. |
Delaware |
2357213 |
0 |
2359787 |
0 |
2359787 |
2.6 % |
08/07/2022 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
143487 |
0 |
143487 |
143487 |
0.2 % |
14/02/2022 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
1442543 |
0 |
1442543 |
1442543 |
1.6 % |
14/02/2022 |
| Steven A. Cohen |
United States |
0 |
1603163 |
0 |
1603163 |
1603163 |
1.8 % |
14/02/2022 |
| Point72 Hong Kong Limited |
Hong Kong |
0 |
17133 |
0 |
17133 |
17133 |
0.1 % |
14/02/2022 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
1442543 |
0 |
1442543 |
1442543 |
1.6 % |
14/02/2022 |
| Lee S. Ainslie III |
United States of America |
0 |
7790478 |
0 |
7790478 |
7790478 |
8.5 % |
14/02/2022 |
| Maverick Capital Management, LLC – |
Texas |
0 |
7790478 |
0 |
7790478 |
7790478 |
8.5 % |
14/02/2022 |
| Maverick Capital, Ltd. – |
Texas |
0 |
7790478 |
0 |
7790478 |
7790478 |
8.5 % |
14/02/2022 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
7651353 |
0 |
7799328 |
7799328 |
8.51 % |
11/02/2022 |
| SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
6312478 |
0 |
6335078 |
6335078 |
6.92 % |
11/02/2022 |
| Sio Capital Management, LLC |
|
0 |
3866645 |
0 |
3866645 |
3866645 |
0 % |
10/02/2022 |
| Sio Capital Management, LLC |
|
0 |
3866645 |
0 |
3866645 |
3866645 |
0 % |
10/02/2022 |
| BlackRock, Inc. |
Delaware |
6164734 |
0 |
6281041 |
0 |
6281041 |
6.9 % |
04/02/2022 |
| Peter Kolchinsky |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
15/11/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
15/11/2021 |
| Rajeev Shah |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
15/11/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
15/11/2021 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
15/11/2021 |
| Peter Kolchinsky |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
15/11/2021 |
| Rajeev Shah |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
15/11/2021 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
15/11/2021 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
5339543 |
0 |
5339543 |
5339543 |
5.8 % |
22/03/2021 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
5339543 |
0 |
5339543 |
5339543 |
5.8 % |
22/03/2021 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
400 |
0 |
400 |
400 |
0.1 % |
22/03/2021 |
| Steven A. Cohen |
United States |
0 |
5339943 |
0 |
5339943 |
5339943 |
5.8 % |
22/03/2021 |
| Cubist Systematic Strategies, LLC |
Delaware |
0 |
400 |
0 |
400 |
400 |
0.1 % |
22/03/2021 |
| Point72 Capital Advisors, Inc. |
Delaware |
0 |
5339543 |
0 |
5339543 |
5339543 |
5.8 % |
22/03/2021 |
| Point72 Asset Management, L.P. |
Delaware |
0 |
5339543 |
0 |
5339543 |
5339543 |
5.8 % |
22/03/2021 |
| Steven A. Cohen |
United States |
0 |
5339943 |
0 |
5339943 |
5339943 |
5.8 % |
22/03/2021 |
| Peter Kolchinsky |
United States of America |
0 |
7707790 |
0 |
7707790 |
7707790 |
8.5 % |
16/02/2021 |
| Rajeev Shah |
United States of America |
0 |
7707790 |
0 |
7707790 |
7707790 |
8.5 % |
16/02/2021 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
7129350 |
0 |
7129350 |
0 |
7.8 % |
16/02/2021 |
| Rajeev Shah |
United States of America |
0 |
7707790 |
0 |
7707790 |
7707790 |
8.5 % |
16/02/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
7707790 |
0 |
7707790 |
7707790 |
8.5 % |
16/02/2021 |
| RA Capital Management, L.P. |
Delaware |
0 |
7707790 |
0 |
7707790 |
7707790 |
8.5 % |
16/02/2021 |
| RA Capital Healthcare Fund, L.P. |
Delaware |
0 |
7129350 |
0 |
7129350 |
0 |
7.8 % |
16/02/2021 |
| Peter Kolchinsky |
United States of America |
0 |
7707790 |
0 |
7707790 |
7707790 |
8.5 % |
16/02/2021 |
| Sio Capital Management, LLC |
|
0 |
4756438 |
0 |
4756438 |
4756438 |
0 % |
16/02/2021 |
| Sio Capital Management, LLC |
|
0 |
4756438 |
0 |
4756438 |
4756438 |
0 % |
16/02/2021 |
| BVF Inc. |
Delaware |
0 |
626945 |
0 |
626945 |
626945 |
0 % |
11/02/2021 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
575485 |
0 |
575485 |
575485 |
0 % |
11/02/2021 |
| BVF Partners L.P. |
Delaware |
0 |
626945 |
0 |
626945 |
626945 |
0 % |
11/02/2021 |
| BVF I GP LLC |
Delaware |
0 |
331472 |
0 |
331472 |
331472 |
0 % |
11/02/2021 |
| Mark N. Lampert |
United States |
0 |
626945 |
0 |
626945 |
626945 |
0 % |
11/02/2021 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
331472 |
0 |
331472 |
331472 |
0 % |
11/02/2021 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
40044 |
0 |
40044 |
40044 |
0 % |
11/02/2021 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
244013 |
0 |
244013 |
244013 |
0 % |
11/02/2021 |
| BVF II GP LLC |
Delaware |
0 |
244013 |
0 |
244013 |
244013 |
0 % |
11/02/2021 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
40044 |
0 |
40044 |
40044 |
0 % |
11/02/2021 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.49 % |
01/02/2021 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.49 % |
01/02/2021 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.49 % |
01/02/2021 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.49 % |
01/02/2021 |
| Robert Atchinson |
United States |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.49 % |
01/02/2021 |
| Phillip Gross |
United States |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.49 % |
01/02/2021 |
| Phillip Gross |
United States |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.49 % |
01/02/2021 |
| Robert Atchinson |
United States |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.49 % |
01/02/2021 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.49 % |
01/02/2021 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
5000000 |
0 |
5000000 |
5000000 |
5.49 % |
01/02/2021 |
| Hal Mintz |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
06/01/2021 |
| Hal Mintz |
USA |
0 |
0 |
0 |
0 |
0 |
0 % |
06/01/2021 |
| Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
06/01/2021 |
| Sabby Management, LLC |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
06/01/2021 |
| Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
0 |
0 |
0 |
0 |
0 % |
06/01/2021 |
| Sabby Management, LLC |
Delaware USA |
0 |
0 |
0 |
0 |
0 |
0 % |
06/01/2021 |
| BVF Partners L.P. |
Delaware |
0 |
3650000 |
0 |
3650000 |
3650000 |
7.2 % |
22/06/2020 |
| BVF Inc. |
Delaware |
0 |
3650000 |
0 |
3650000 |
3650000 |
7.2 % |
22/06/2020 |
| Mark N. Lampert |
United States |
0 |
3650000 |
0 |
3650000 |
3650000 |
7.2 % |
22/06/2020 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
3327158 |
0 |
3327158 |
3327158 |
6.6 % |
22/06/2020 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
247806 |
0 |
247806 |
247806 |
0 % |
22/06/2020 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
247806 |
0 |
247806 |
247806 |
0 % |
22/06/2020 |
| BVF II GP LLC |
Delaware |
0 |
1421676 |
0 |
1421676 |
1421676 |
2.8 % |
22/06/2020 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1421676 |
0 |
1421676 |
1421676 |
2.8 % |
22/06/2020 |
| BVF I GP LLC |
Delaware |
0 |
1905482 |
0 |
1905482 |
1905482 |
3.8 % |
22/06/2020 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
1095482 |
0 |
1905482 |
1905482 |
3.8 % |
22/06/2020 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
1095482 |
0 |
1905482 |
1905482 |
3.8 % |
22/06/2020 |
| BVF I GP LLC |
Delaware |
0 |
1905482 |
0 |
1905482 |
1905482 |
3.8 % |
22/06/2020 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
1421676 |
0 |
1421676 |
1421676 |
2.8 % |
22/06/2020 |
| BVF II GP LLC |
Delaware |
0 |
1421676 |
0 |
1421676 |
1421676 |
2.8 % |
22/06/2020 |
| Biotechnology Value Trading Fund OS LP |
Cayman Islands |
0 |
247806 |
0 |
247806 |
247806 |
0 % |
22/06/2020 |
| BVF Partners L.P. |
Delaware |
0 |
3650000 |
0 |
3650000 |
3650000 |
7.2 % |
22/06/2020 |
| BVF Inc. |
Delaware |
0 |
3650000 |
0 |
3650000 |
3650000 |
7.2 % |
22/06/2020 |
| Mark N. Lampert |
United States |
0 |
3650000 |
0 |
3650000 |
3650000 |
7.2 % |
22/06/2020 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
3327158 |
0 |
3327158 |
3327158 |
6.6 % |
22/06/2020 |
| BVF Partners OS Ltd. |
Cayman Islands |
0 |
247806 |
0 |
247806 |
247806 |
0 % |
22/06/2020 |
| Hal Mintz |
USA |
0 |
3650000 |
0 |
3650000 |
3650000 |
7.22 % |
11/06/2020 |
| Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
3650000 |
0 |
3650000 |
3650000 |
7.22 % |
11/06/2020 |
| Hal Mintz |
USA |
0 |
3650000 |
0 |
3650000 |
3650000 |
7.22 % |
11/06/2020 |
| Sabby Management, LLC |
Delaware USA |
0 |
3650000 |
0 |
3650000 |
3650000 |
7.22 % |
11/06/2020 |
| Sabby Volatility Warrant Master Fund, Ltd. |
Cayman Islands |
0 |
3650000 |
0 |
3650000 |
3650000 |
7.22 % |
11/06/2020 |
| Sabby Management, LLC |
Delaware USA |
0 |
3650000 |
0 |
3650000 |
3650000 |
7.22 % |
11/06/2020 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| EcoR1 Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Oleg Nodelman |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| EcoR1 Capital, LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| Oleg Nodelman |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
14/02/2020 |
| First Eagle Investment Management, LLC |
State of Delaware |
448547 |
0 |
448547 |
0 |
448547 |
1.35 % |
08/01/2019 |
| First Eagle Investment Management, LLC |
State of Delaware |
448547 |
0 |
448547 |
0 |
448547 |
1.35 % |
08/01/2019 |
| EcoR1 Capital, LLC |
Delaware |
0 |
2982208 |
0 |
2982208 |
2982208 |
9 % |
27/12/2018 |
| EcoR1 Capital Fund Qualified, L.P. |
Delaware |
0 |
2491288 |
0 |
2491288 |
2491288 |
7.5 % |
27/12/2018 |
| Oleg Nodelman |
United States |
0 |
2982208 |
0 |
2982208 |
2982208 |
9 % |
27/12/2018 |
| BlackRock, Inc. |
Delaware |
805076 |
0 |
805076 |
0 |
805076 |
2.4 % |
10/07/2018 |
| First Eagle Investment Management, LLC |
State of Delaware |
24579977 |
0 |
24904977 |
0 |
24904977 |
15.18 % |
07/02/2018 |
| BlackRock, Inc. |
Delaware |
9559706 |
0 |
9719497 |
0 |
9719497 |
5.9 % |
29/01/2018 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
7206044 |
0 |
7206044 |
4.394 % |
10/01/2018 |
| FMR LLC |
Delaware |
0 |
0 |
7206044 |
0 |
7206044 |
4.394 % |
10/01/2018 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
14738379 |
0 |
14738379 |
10.486 % |
14/02/2017 |
| FMR LLC |
Delaware |
168400 |
0 |
14738379 |
0 |
14738379 |
10.486 % |
14/02/2017 |
| BlackRock, Inc. |
Delaware |
9086354 |
0 |
9224225 |
0 |
9224225 |
6.6 % |
23/01/2017 |
| Dr. Reddy’s Laboratories Ltd. |
Republic of India |
27328464 |
0 |
27328464 |
0 |
27328464 |
19.6 % |
13/09/2016 |
| Dr. Reddy’s Holdings Limited |
Republic of India |
27328464 |
0 |
27328464 |
0 |
27328464 |
19.6 % |
13/09/2016 |
| Aurigene Discovery Technologies Limited |
Republic of India |
27328464 |
0 |
27328464 |
0 |
27328464 |
19.6 % |
13/09/2016 |
| First Eagle Investment Management, LLC |
State of Delaware |
23683672 |
0 |
24008672 |
0 |
24008672 |
18.7 % |
01/02/2016 |
| BlackRock, Inc. |
Delaware |
7896347 |
0 |
8042694 |
0 |
8042694 |
6.3 % |
28/01/2016 |
| Select Health Care Portfolio |
Massachusetts |
6824653 |
0 |
0 |
0 |
6824653 |
5.461 % |
10/03/2015 |
| FMR LLC |
Delaware |
0 |
0 |
16628799 |
0 |
16628799 |
13.306 % |
10/03/2015 |
| Edward C. Johnson 3d |
United States of America |
0 |
0 |
16628799 |
0 |
16628799 |
13.306 % |
10/03/2015 |
| Abigail P. Johnson |
United States of America |
0 |
0 |
16628799 |
0 |
16628799 |
13.306 % |
10/03/2015 |
| First Eagle Investment Management, LLC |
State of Delaware |
23683672 |
0 |
24008672 |
0 |
24008672 |
18.72 % |
09/03/2015 |
| First Eagle Investment Management, LLC |
State of Delaware |
20292445 |
0 |
20617445 |
0 |
20617445 |
23.9 % |
29/01/2015 |
| Dr. Reddy’s Holdings Limited |
Republic of India |
17120131 |
0 |
17120131 |
0 |
17120131 |
16.6 % |
28/01/2015 |
| Dr. Reddy’s Laboratories Ltd. |
Republic of India |
17120131 |
0 |
17120131 |
0 |
17120131 |
16.6 % |
28/01/2015 |
| Aurigene Discovery Technologies Limited |
Republic of India |
17120131 |
0 |
17120131 |
0 |
17120131 |
16.6 % |
28/01/2015 |
| BlackRock, Inc. |
Delaware |
3609355 |
0 |
3609355 |
0 |
3609355 |
4.2 % |
10/07/2014 |
| First Eagle Investment Management, LLC |
State of Delaware |
18134082 |
0 |
18134082 |
0 |
18134082 |
21.08 % |
14/02/2014 |
| BlackRock, Inc. |
Delaware |
6457670 |
0 |
6682654 |
0 |
6682654 |
7.8 % |
28/01/2014 |
| First Eagle Investment Management, LLC |
State of Delaware |
17094140 |
0 |
17094140 |
0 |
17094140 |
21.31 % |
14/06/2013 |
| Ft Eagle Investment Management, LLC |
Delaware |
16921529 |
0 |
16921529 |
0 |
16921529 |
21.1 % |
11/02/2013 |
| BlackRock, Inc. |
Delaware |
5327891 |
0 |
5327891 |
0 |
5327891 |
6.66 % |
06/02/2013 |
| BlackRock, Inc. |
Delaware |
4724641 |
0 |
4724641 |
0 |
4724641 |
6.17 % |
13/02/2012 |
| First Eagle Investment Management, LLC |
State of Delaware |
17360286 |
0 |
17360286 |
0 |
17360286 |
22.6 % |
30/01/2012 |
| First Eagle Investment Management, LLC |
State of Delaware |
17495175 |
0 |
17495175 |
0 |
17495175 |
22.77 % |
30/01/2012 |
| First Eagle Investment Management, LLC |
State of Delaware |
17631140 |
0 |
17631140 |
0 |
17631140 |
23.23 % |
16/03/2011 |
| First Eagle Investment Management, LLC |
State of Delaware |
17691198 |
0 |
17691198 |
0 |
17691198 |
22.84 % |
15/02/2011 |
| Ft Eagle Investment Management, LLC |
Delaware |
16611969 |
0 |
16611969 |
0 |
16611969 |
22.84 % |
10/02/2011 |
| BlackRock, Inc. |
Delaware |
4262432 |
0 |
4262432 |
0 |
4262432 |
5.64 % |
04/02/2011 |
| OrbiMed Advisors LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
21/06/2010 |
| Samuel D. Isaly |
United States |
0 |
0 |
0 |
0 |
0 |
0 % |
21/06/2010 |
| OrbiMed Capital LLC |
Delaware |
0 |
0 |
0 |
0 |
0 |
0 % |
21/06/2010 |
| Mark N. Lampert |
United States |
0 |
658050 |
0 |
658050 |
658050 |
1 % |
10/02/2010 |
| BVF Inc. |
Delaware |
0 |
658050 |
0 |
658050 |
658050 |
1 % |
10/02/2010 |
| BVF Partners L.P. |
Delaware |
0 |
658050 |
0 |
658050 |
658050 |
1 % |
10/02/2010 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
150759 |
0 |
150759 |
150759 |
1 % |
10/02/2010 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
103051 |
0 |
103051 |
103051 |
1 % |
10/02/2010 |
| BVF Investments, L.L.C. |
Delaware |
0 |
359887 |
0 |
359887 |
359887 |
1 % |
10/02/2010 |
| Investment 10, L.L.C. |
Illinois |
0 |
44353 |
0 |
44353 |
44353 |
1 % |
10/02/2010 |
| Ft Eagle Investment Management, LLC |
Delaware |
13317969 |
0 |
13317969 |
0 |
13317969 |
19.79 % |
10/02/2010 |
| (ENTITIES ONLY): |
Delaware |
0 |
6173591 |
0 |
6173591 |
6173591 |
9.7 % |
01/02/2008 |
| I.R.S. Identification Nos. of above persons (entities only). |
Delaware |
132362 |
0 |
132362 |
0 |
132362 |
0 % |
15/08/2007 |
