| M. Kingdon Offshore Master Fund L.P. |
Delaware |
0 |
311157 |
0 |
311157 |
311157 |
5.3 % |
15/04/2024 |
| Kingdon Capital Management, L.L.C. |
Delaware |
0 |
345730 |
0 |
345730 |
345730 |
5.9 % |
15/04/2024 |
| Mark Kingdon |
Delaware |
0 |
345730 |
0 |
345730 |
345730 |
5.9 % |
15/04/2024 |
| Kingdon GP, LLC |
Delaware |
0 |
311157 |
0 |
311157 |
311157 |
5.3 % |
15/04/2024 |
| Marc Elia |
United States |
0 |
421951 |
0 |
0 |
421951 |
7.2 % |
12/02/2024 |
| M28 Capital Management LP |
Delaware |
0 |
421951 |
0 |
0 |
421951 |
7.2 % |
12/02/2024 |
| (1) BlackRock, Inc. |
Delaware |
2357213 |
0 |
2359787 |
0 |
2359787 |
2.6 % |
08/07/2022 |
| III |
United States of America |
0 |
7790478 |
0 |
7790478 |
7790478 |
8.5 % |
14/02/2022 |
| 75-2482446 |
United States of America |
0 |
7790478 |
0 |
7790478 |
7790478 |
8.5 % |
14/02/2022 |
| 75-2686461 |
United States of America |
0 |
7790478 |
0 |
7790478 |
7790478 |
8.5 % |
14/02/2022 |
| SSGA FUNDS MANAGEMENT, INC. |
BOSTON, MASSACHUSETTS |
0 |
6312478 |
0 |
6335078 |
6335078 |
6.92 % |
11/02/2022 |
| STATE STREET CORPORATION |
BOSTON, MASSACHUSETTS |
0 |
7651353 |
0 |
7799328 |
7799328 |
8.51 % |
11/02/2022 |
| Sio Capital Management, LLC
20-4586565 |
|
0 |
3866645 |
0 |
3866645 |
3866645 |
4.22 % |
10/02/2022 |
| Robert Atchinson |
United States |
0 |
200000 |
0 |
0 |
200000 |
0.22 % |
10/02/2022 |
| Phillip Gross |
United States |
0 |
200000 |
0 |
0 |
200000 |
0.22 % |
10/02/2022 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
200000 |
0 |
0 |
200000 |
0.22 % |
10/02/2022 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
200000 |
0 |
0 |
200000 |
0.22 % |
10/02/2022 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
200000 |
0 |
0 |
200000 |
0.22 % |
10/02/2022 |
| (1) BlackRock, Inc. |
Delaware |
6164734 |
0 |
6281041 |
0 |
6281041 |
6.9 % |
04/02/2022 |
| 2 |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
15/11/2021 |
| 2 |
United States of America |
0 |
0 |
0 |
0 |
10 |
0 % |
15/11/2021 |
| 2 |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
15/11/2021 |
| 2 |
United States of America |
0 |
0 |
0 |
0 |
0 |
0 % |
15/11/2021 |
| Cubist Systematic Strategies, LLC |
Citizenship or place of organization Delaware |
0 |
400 |
0 |
400 |
400 |
4 % |
22/03/2021 |
| Point72 Capital Advisors, Inc. |
Citizenship or place of organization Delaware |
0 |
5339543 |
0 |
5339543 |
5339543 |
4 % |
22/03/2021 |
| Point72 Asset Management, L.P. |
Citizenship or place of organization Delaware |
0 |
5339543 |
0 |
5339543 |
5339543 |
4 % |
22/03/2021 |
| Steven A. Cohen |
Citizenship or place of organization United States |
0 |
5339943 |
0 |
5339943 |
5339943 |
4 % |
22/03/2021 |
| Rajeev Shah |
Delaware |
0 |
7129350 |
0 |
7129350 |
7707790 |
8.5 % |
16/02/2021 |
| Sio Capital Management, LLC
20-4586565 |
|
0 |
4756438 |
0 |
4756438 |
4756438 |
5.78 % |
16/02/2021 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
331472 |
331472 |
1 % |
11/02/2021 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
244013 |
244013 |
1 % |
11/02/2021 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
575485 |
575485 |
1 % |
11/02/2021 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
626945 |
626945 |
1 % |
11/02/2021 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
626945 |
626945 |
1 % |
11/02/2021 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
40044 |
40044 |
1 % |
11/02/2021 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
244013 |
244013 |
1 % |
11/02/2021 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
40044 |
40044 |
1 % |
11/02/2021 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
626945 |
626945 |
1 % |
11/02/2021 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
331472 |
331472 |
1 % |
11/02/2021 |
| Phillip Gross |
United States |
0 |
5000000 |
0 |
0 |
5000000 |
5.49 % |
01/02/2021 |
| Adage Capital Advisors, L.L.C. |
Delaware |
0 |
5000000 |
0 |
0 |
5000000 |
5.49 % |
01/02/2021 |
| Robert Atchinson |
United States |
0 |
5000000 |
0 |
0 |
5000000 |
5.49 % |
01/02/2021 |
| Adage Capital Partners GP, L.L.C. |
Delaware |
0 |
5000000 |
0 |
0 |
5000000 |
5.49 % |
01/02/2021 |
| Adage Capital Partners, L.P. |
Delaware |
0 |
5000000 |
0 |
0 |
5000000 |
5.49 % |
01/02/2021 |
| Biotechnology Value Trading Fund OS LP |
Delaware |
0 |
0 |
0 |
247806 |
247806 |
1 % |
22/06/2020 |
| BVF Partners OS Ltd. |
Delaware |
0 |
0 |
0 |
247806 |
247806 |
1 % |
22/06/2020 |
| BVF GP HOLDINGS LLC |
Delaware |
0 |
0 |
0 |
3327158 |
3327158 |
6.6 % |
22/06/2020 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
3650000 |
3650000 |
7.2 % |
22/06/2020 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
3650000 |
3650000 |
7.2 % |
22/06/2020 |
| Mark N. Lampert |
Delaware |
0 |
0 |
0 |
3650000 |
3650000 |
7.2 % |
22/06/2020 |
| BVF II GP LLC |
Delaware |
0 |
0 |
0 |
1421676 |
1421676 |
2.8 % |
22/06/2020 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
1421676 |
1421676 |
2.8 % |
22/06/2020 |
| BVF I GP LLC |
Delaware |
0 |
0 |
0 |
1905482 |
1905482 |
3.8 % |
22/06/2020 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
1905482 |
1905482 |
3.8 % |
22/06/2020 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
448547 |
1.35 % |
08/01/2019 |
| (1) BlackRock, Inc. |
Delaware |
805076 |
0 |
805076 |
0 |
805076 |
2.4 % |
10/07/2018 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
24904977 |
15.18 % |
07/02/2018 |
| (1) BlackRock, Inc. |
Delaware |
9559706 |
0 |
9719497 |
0 |
9719497 |
5.9 % |
29/01/2018 |
| FMR LLC |
Delaware |
0 |
0 |
7206044 |
0 |
7206044 |
4.394 % |
10/01/2018 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
7206044 |
0 |
7206044 |
4.394 % |
10/01/2018 |
| (1) BlackRock, Inc. |
Delaware |
9086354 |
0 |
9224225 |
0 |
9224225 |
6.6 % |
23/01/2017 |
| 2 |
Republic of India |
27328464 |
0 |
27328464 |
0 |
27328464 |
19.6 % |
13/09/2016 |
| 2 |
Republic of India |
27328464 |
0 |
27328464 |
0 |
27328464 |
19.6 % |
13/09/2016 |
| 2 |
Republic of India |
27328464 |
0 |
27328464 |
0 |
27328464 |
19.6 % |
13/09/2016 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
24008672 |
18.7 % |
01/02/2016 |
| (1) BlackRock, Inc. |
Delaware |
7896347 |
0 |
8042694 |
0 |
8042694 |
6.3 % |
28/01/2016 |
| Abigail P. Johnson |
Delaware |
0 |
0 |
16628799 |
0 |
16628799 |
13.306 % |
10/03/2015 |
| Edward C. Johnson 3d |
Delaware |
0 |
0 |
16628799 |
0 |
16628799 |
13.306 % |
10/03/2015 |
| FMR LLC |
Delaware |
0 |
0 |
16628799 |
0 |
16628799 |
13.306 % |
10/03/2015 |
| Select Health Care Portfolio |
Delaware |
6824653 |
0 |
0 |
0 |
6824653 |
5.461 % |
10/03/2015 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
24008672 |
18.72 % |
09/03/2015 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
20617445 |
23.9 % |
29/01/2015 |
| 2 |
Republic of India |
17120131 |
0 |
17120131 |
0 |
17120131 |
16.6 % |
28/01/2015 |
| 2 |
Republic of India |
17120131 |
0 |
17120131 |
0 |
17120131 |
16.6 % |
28/01/2015 |
| 2 |
Republic of India |
17120131 |
0 |
17120131 |
0 |
17120131 |
16.6 % |
28/01/2015 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
18134082 |
21.08 % |
14/02/2014 |
| (1) BlackRock, Inc. |
Delaware |
6457670 |
0 |
6682654 |
0 |
6682654 |
7.8 % |
28/01/2014 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
17094140 |
21.31 % |
14/06/2013 |
| Battery Ventures VIII, L.P. (“BV8”) |
Pennsylvania |
129472 |
|
4476257 |
127972 |
6869220 |
13.7 % |
12/02/2013 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
16921529 |
21.1 % |
11/02/2013 |
| (1) BlackRock, Inc. |
Delaware |
5327891 |
0 |
5327891 |
0 |
5327891 |
6.66 % |
06/02/2013 |
| (1) BlackRock, Inc. |
Delaware |
4724641 |
0 |
4724641 |
0 |
4724641 |
6.17 % |
13/02/2012 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
17360286 |
22.6 % |
30/01/2012 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
17495175 |
22.77 % |
30/01/2012 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
17631140 |
23.23 % |
16/03/2011 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
17691198 |
22.84 % |
15/02/2011 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
16611969 |
22.84 % |
10/02/2011 |
| (1) BlackRock, Inc. |
Delaware |
4262432 |
0 |
4262432 |
0 |
4262432 |
5.64 % |
04/02/2011 |
| OrbiMed Advisors LLC |
Delaware |
0 |
435400 |
0 |
435400 |
435400 |
11 % |
12/02/2010 |
| Samuel D. Isaly |
Delaware |
0 |
3834484 |
0 |
3834484 |
3834484 |
11 % |
12/02/2010 |
| OrbiMed Capital LLC |
Delaware |
0 |
3399084 |
0 |
3399084 |
3399084 |
11 % |
12/02/2010 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
12427225 |
18.7 % |
07/08/2009 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
10250782 |
16.1 % |
05/05/2009 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
6766877 |
10.66 % |
12/02/2009 |
| Tax ID # 57-1156902 |
State of Delaware |
0 |
0 |
0 |
0 |
6413845 |
10.11 % |
05/12/2008 |
| PAUL
H. STEPHENS |
United
States |
300000 |
3976607 |
300000 |
0 |
4276607 |
6.8 % |
12/02/2008 |
| P.
BARTLETT STEPHENS |
United
States |
0 |
3976607 |
0 |
0 |
3976607 |
6.3 % |
12/02/2008 |
| W.
BRADFORD STEPHENS |
United
States |
0 |
3976607 |
0 |
0 |
3976607 |
6.3 % |
12/02/2008 |
| STEPHENS
INVESTMENT MANAGEMENT, LLC |
Delaware |
3976607 |
0 |
3976607 |
0 |
3976607 |
6.3 % |
12/02/2008 |
| STEPHENS
INVESTMENT MANAGEMENT, LLC |
Delaware |
3976607 |
0 |
3976607 |
0 |
3976607 |
6.3 % |
12/02/2008 |
| W.
BRADFORD STEPHENS |
United
States |
0 |
3976607 |
0 |
0 |
3976607 |
6.3 % |
12/02/2008 |
| PAUL
H. STEPHENS |
United
States |
300000 |
3976607 |
300000 |
0 |
4276607 |
6.8 % |
12/02/2008 |
| P.
BARTLETT STEPHENS |
United
States |
0 |
3976607 |
0 |
0 |
3976607 |
6.3 % |
12/02/2008 |
| W.
BRADFORD STEPHENS |
United
States |
0 |
3976607 |
0 |
0 |
3976607 |
6.3 % |
12/02/2008 |
| PAUL
H. STEPHENS |
United
States |
300000 |
3976607 |
300000 |
0 |
4276607 |
6.8 % |
12/02/2008 |
| P.
BARTLETT STEPHENS |
United
States |
0 |
3976607 |
0 |
0 |
3976607 |
6.3 % |
12/02/2008 |
| STEPHENS
INVESTMENT MANAGEMENT, LLC |
Delaware |
3976607 |
0 |
3976607 |
0 |
3976607 |
6.3 % |
12/02/2008 |
| STEPHENS
INVESTMENT MANAGEMENT, LLC |
Delaware |
3976607 |
0 |
3976607 |
0 |
3976607 |
6.3 % |
12/02/2008 |
| PAUL
H. STEPHENS |
United
States |
300000 |
3976607 |
300000 |
0 |
4276607 |
6.8 % |
12/02/2008 |
| P.
BARTLETT STEPHENS |
United
States |
0 |
3976607 |
0 |
0 |
3976607 |
6.3 % |
12/02/2008 |
| W.
BRADFORD STEPHENS |
United
States |
0 |
3976607 |
0 |
0 |
3976607 |
6.3 % |
12/02/2008 |
| Biotechnology Value Fund, L.P. |
Delaware |
0 |
0 |
0 |
1376199 |
1376199 |
2.2 % |
01/02/2008 |
| BVF Partners L.P. |
Delaware |
0 |
0 |
0 |
6173591 |
6173591 |
9.7 % |
01/02/2008 |
| Biotechnology Value Fund II, L.P. |
Delaware |
0 |
0 |
0 |
939681 |
939681 |
1.5 % |
01/02/2008 |
| BVF Investments, L.L.C. |
Delaware |
0 |
0 |
0 |
3458336 |
3458336 |
5.4 % |
01/02/2008 |
| Investment 10, L.L.C. |
Delaware |
0 |
0 |
0 |
399375 |
399375 |
0.6 % |
01/02/2008 |
| BVF Inc. |
Delaware |
0 |
0 |
0 |
6173591 |
6173591 |
9.7 % |
01/02/2008 |
| RA Capital Biotech Fund II, L.P. |
Citizenship or Place of Organization |
0 |
0 |
0 |
0 |
132362 |
0 % |
15/08/2007 |
| Peter Kolchinsky |
Citizenship or Place of Organization |
0 |
0 |
0 |
7520564 |
7520564 |
11.9 % |
15/08/2007 |
| RA Capital Biotech Fund, L.P. |
Citizenship or Place of Organization |
0 |
0 |
0 |
0 |
7388202 |
11.7 % |
15/08/2007 |
| Richard H. Aldrich |
Citizenship or Place of Organization |
0 |
0 |
0 |
7520564 |
7520564 |
11.9 % |
15/08/2007 |
| Capital Management, LLC |
Citizenship or Place of Organization |
0 |
0 |
0 |
0 |
7520564 |
11.9 % |
15/08/2007 |
| Vulcan Ventures Incorporated |
State of Washington |
0 |
918663 |
0 |
0 |
918663 |
2.2 % |
23/03/2004 |
| Paul G. Allen |
United States of America |
0 |
918663 |
0 |
0 |
918663 |
2.2 % |
23/03/2004 |